| Year |
Citation |
Score |
| 2024 |
Paquette AR, Brazeau-Henrie JT, Boddy CN. Thioesterases as tools for chemoenzymatic synthesis of macrolactones. Chemical Communications (Cambridge, England). PMID 38456624 DOI: 10.1039/d4cc00401a |
0.321 |
|
| 2022 |
Brazeau-Henrie JT, Paquette AR, O'Rourke AQ, Darnowski MG, Boddy CN. Total and Chemoenzymatic Synthesis of Seongsanamide E. Organic Letters. PMID 36006794 DOI: 10.1021/acs.orglett.2c02271 |
0.304 |
|
| 2022 |
Paquette AR, Payne SR, McKay GA, Brazeau-Henrie JT, Darnowski MG, Kammili A, Bernal F, Mah TF, Gruenheid S, Nguyen D, Boddy CN. RpoN-Based stapled peptides with improved DNA binding suppress virulence. Rsc Medicinal Chemistry. 13: 445-455. PMID 35647551 DOI: 10.1039/d1md00371b |
0.537 |
|
| 2020 |
Heberlig GW, Boddy CN. Thioesterase from Cereulide Biosynthesis Is Responsible for Oligomerization and Macrocyclization of a Linear Tetradepsipeptide. Journal of Natural Products. 83: 1990-1997. PMID 32519859 DOI: 10.1021/Acs.Jnatprod.0C00333 |
0.442 |
|
| 2019 |
Gosse JT, Ghosh S, Sproule A, Overy D, Cheeptham N, Boddy CN. Whole Genome Sequencing and Metabolomic Study of Cave Isolates ICC1 and ICC4. Frontiers in Microbiology. 10: 1020. PMID 31134037 DOI: 10.3389/Fmicb.2019.01020 |
0.343 |
|
| 2018 |
Huguenin-Dezot N, Alonzo DA, Heberlig GW, Mahesh M, Nguyen DP, Dornan MH, Boddy CN, Schmeing TM, Chin JW. Trapping biosynthetic acyl-enzyme intermediates with encoded 2,3-diaminopropionic acid. Nature. PMID 30542153 DOI: 10.1038/S41586-018-0781-Z |
0.387 |
|
| 2018 |
Heberlig GW, Brown JTC, Simard RD, Wirz M, Zhang W, Wang M, Susser LI, Horsman ME, Boddy CN. Chemoenzymatic macrocycle synthesis using resorcylic acid lactone thioesterase domains. Organic & Biomolecular Chemistry. PMID 30052255 DOI: 10.1039/C8Ob01512K |
0.489 |
|
| 2018 |
Payne SR, Pau DI, Whiting AL, Kim YJ, Pharoah BM, Moi C, Boddy CN, Bernal F. Inhibition of Bacterial Gene Transcription with an RpoN-Based Stapled Peptide. Cell Chemical Biology. PMID 29887265 DOI: 10.1016/J.Chembiol.2018.05.007 |
0.59 |
|
| 2017 |
Hassan MI, McSorley FR, Hotta K, Boddy CN. Inducible T7 RNA Polymerase-mediated Multigene Expression System, pMGX. Journal of Visualized Experiments : Jove. PMID 28715370 DOI: 10.3791/55187 |
0.301 |
|
| 2017 |
Hill P, Heberlig GW, Boddy CN. Sampling Terrestrial Environments for Bacterial Polyketides. Molecules (Basel, Switzerland). 22. PMID 28468277 DOI: 10.3390/Molecules22050707 |
0.302 |
|
| 2016 |
Horsman ME, Boddy CN. Natural products: Mapping an amazing thicket. Nature Chemical Biology. 13: 6-7. PMID 27984578 DOI: 10.1038/Nchembio.2265 |
0.318 |
|
| 2016 |
Pardee K, Slomovic S, Nguyen PQ, Lee JW, Donghia N, Burrill D, Ferrante T, McSorley FR, Furuta Y, Vernet A, Lewandowski M, Boddy CN, Joshi NS, Collins JJ. Portable, On-Demand Biomolecular Manufacturing. Cell. 167: 248-259.e12. PMID 27662092 DOI: 10.1016/J.Cell.2016.09.013 |
0.364 |
|
| 2016 |
Hassan MI, Lundgren BR, Chaumun M, Whitfield DM, Clark B, Schoenhofen IC, Boddy CN. Total Biosynthesis of Legionaminic Acid, a Bacterial Sialic Acid Analogue. Angewandte Chemie (International Ed. in English). PMID 27538580 DOI: 10.1002/Anie.201606006 |
0.326 |
|
| 2016 |
Tremblay N, Hill P, Conway KR, Boddy CN. The Use of ClusterMine360 for the Analysis of Polyketide and Nonribosomal Peptide Biosynthetic Pathways. Methods in Molecular Biology (Clifton, N.J.). 1401: 233-52. PMID 26831712 DOI: 10.1007/978-1-4939-3375-4_15 |
0.339 |
|
| 2016 |
Horsman ME, Lundgren BR, Boddy CN. N-Acetylneuraminic Acid Production inEscherichia coliLacking N-Acetylglucosamine Catabolic Machinery Chemical Engineering Communications. 203: 1326-1335. DOI: 10.1080/00986445.2016.1188293 |
0.343 |
|
| 2015 |
Hari TP, Wilke BI, Davey JA, Boddy CN. Diastereoseletive Transannular Oxa-Conjugate Addition Generates the 2,6-cis-Disubstituted Tetrahydropyran of Neopeltolide. The Journal of Organic Chemistry. PMID 26675500 DOI: 10.1021/Acs.Joc.5B02014 |
0.734 |
|
| 2015 |
Argyropoulos P, Bergeret F, Pardin C, Reimer JM, Pinto A, Boddy CN, Martin Schmeing T. Towards a characterization of the structural determinants of specificity in the macrocyclizing thioesterase for deoxyerythronolide B biosynthesis. Biochimica Et Biophysica Acta. PMID 26592346 DOI: 10.1016/J.Bbagen.2015.11.007 |
0.642 |
|
| 2015 |
Horsman ME, Hari TP, Boddy CN. Polyketide synthase and non-ribosomal peptide synthetase thioesterase selectivity: logic gate or a victim of fate? Natural Product Reports. PMID 25642666 DOI: 10.1039/C4Np00148F |
0.421 |
|
| 2014 |
Heberlig GW, Wirz M, Wang M, Boddy CN. Resorcylic acid lactone biosynthesis relies on a stereotolerant macrocyclizing thioesterase. Organic Letters. 16: 5858-61. PMID 25372311 DOI: 10.1021/Ol502747T |
0.448 |
|
| 2014 |
Hari TP, Labana P, Boileau M, Boddy CN. An evolutionary model encompassing substrate specificity and reactivity of type I polyketide synthase thioesterases. Chembiochem : a European Journal of Chemical Biology. 15: 2656-61. PMID 25354333 DOI: 10.1002/Cbic.201402475 |
0.397 |
|
| 2014 |
Boddy CN. Bioinformatics tools for genome mining of polyketide and non-ribosomal peptides. Journal of Industrial Microbiology & Biotechnology. 41: 443-50. PMID 24174214 DOI: 10.1007/S10295-013-1368-1 |
0.358 |
|
| 2014 |
Bergeret F, Argyropoulos P, Reimer J, Boddy C, Schmeing M. Structural Study of Thioesterase Domains in Complex with Covalent Inhibitors Acta Crystallographica Section a Foundations and Advances. 70: C436-C436. DOI: 10.1107/S2053273314095631 |
0.33 |
|
| 2014 |
Wilke BI, Dornan MH, Yeung J, Boddy CN, Pinto A. Hexanes/acetonitrile: A binary solvent system for the efficient monosilylation of symmetric primary and secondary diols Tetrahedron Letters. 55: 2600-2602. DOI: 10.1016/J.Tetlet.2014.02.067 |
0.705 |
|
| 2013 |
Young J, Stevens DC, Carmichael R, Tan J, Rachid S, Boddy CN, Müller R, Taylor RE. Elucidation of gephyronic acid biosynthetic pathway revealed unexpected SAM-dependent methylations. Journal of Natural Products. 76: 2269-76. PMID 24298873 DOI: 10.1021/Np400629V |
0.658 |
|
| 2013 |
Stevens DC, Hari TP, Boddy CN. The role of transcription in heterologous expression of polyketides in bacterial hosts. Natural Product Reports. 30: 1391-411. PMID 24061690 DOI: 10.1039/C3Np70060G |
0.561 |
|
| 2013 |
Wyatt MA, Ahilan Y, Argyropoulos P, Boddy CN, Magarvey NA, Harrison PH. Biosynthesis of ebelactone A: isotopic tracer, advanced precursor and genetic studies reveal a thioesterase-independent cyclization to give a polyketide β-lactone. The Journal of Antibiotics. 66: 421-30. PMID 23801186 DOI: 10.1038/Ja.2013.48 |
0.399 |
|
| 2013 |
Stevens DC, Conway KR, Pearce N, Villegas-Peñaranda LR, Garza AG, Boddy CN. Alternative sigma factor over-expression enables heterologous expression of a type II polyketide biosynthetic pathway in Escherichia coli. Plos One. 8: e64858. PMID 23724102 DOI: 10.1371/Journal.Pone.0064858 |
0.585 |
|
| 2013 |
Lundgren BR, Thornton W, Dornan MH, Villegas-Peñaranda LR, Boddy CN, Nomura CT. Gene PA2449 is essential for glycine metabolism and pyocyanin biosynthesis in Pseudomonas aeruginosa PAO1. Journal of Bacteriology. 195: 2087-100. PMID 23457254 DOI: 10.1128/Jb.02205-12 |
0.351 |
|
| 2013 |
Conway KR, Boddy CN. ClusterMine360: a database of microbial PKS/NRPS biosynthesis. Nucleic Acids Research. 41: D402-7. PMID 23104377 DOI: 10.1093/Nar/Gks993 |
0.3 |
|
| 2012 |
Pinto A, Boddy CN. Non-canonical regioisomerizations and a 'Diels-Alderase' are likely essential in the biosynthesis of spiculoic acid A. Bioorganic & Medicinal Chemistry Letters. 22: 5253-6. PMID 22801647 DOI: 10.1016/J.Bmcl.2012.06.052 |
0.652 |
|
| 2012 |
Pinto A, Wang M, Horsman M, Boddy CN. 6-Deoxyerythronolide B synthase thioesterase-catalyzed macrocyclization is highly stereoselective. Organic Letters. 14: 2278-81. PMID 22519860 DOI: 10.1021/Ol300707J |
0.651 |
|
| 2011 |
Dixson DD, Boddy CN, Doyle RP. Reinvestigation of coenzyme Q10 isolation from Sporidiobolus johnsonii. Chemistry & Biodiversity. 8: 1033-51. PMID 21674778 DOI: 10.1002/Cbdv.201000278 |
0.324 |
|
| 2010 |
Stevens DC, Henry MR, Murphy KA, Boddy CN. Heterologous expression of the oxytetracycline biosynthetic pathway in Myxococcus xanthus. Applied and Environmental Microbiology. 76: 2681-3. PMID 20208031 DOI: 10.1128/Aem.02841-09 |
0.572 |
|
| 2010 |
Ripin DHB, Teager DS, Fortunak J, Basha SM, Bivins N, Boddy CN, Byrn S, Catlin KK, Houghton SR, Jagadeesh ST, Kumar KA, Melton J, Muneer S, Rao LN, Rao RV, et al. Process improvements for the manufacture of tenofovir disoproxil fumarate at commercial scale Organic Process Research and Development. 14: 1194-1201. DOI: 10.1021/Op1001337 |
0.329 |
|
| 2010 |
Houghton SR, Melton J, Fortunak J, Brown Ripin DH, Boddy CN. Rapid, mild method for phosphonate diester hydrolysis: Development of a one-pot synthesis of tenofovir disoproxil fumarate from tenofovir diethyl ester Tetrahedron. 66: 8137-8144. DOI: 10.1016/J.Tet.2010.08.037 |
0.372 |
|
| 2009 |
Wang M, Zhou H, Wirz M, Tang Y, Boddy CN. A thioesterase from an iterative fungal polyketide synthase shows macrocyclization and cross coupling activity and may play a role in controlling iterative cycling through product offloading. Biochemistry. 48: 6288-90. PMID 19530704 DOI: 10.1021/Bi9009049 |
0.618 |
|
| 2009 |
Wang M, Opare P, Boddy CN. Polyketide synthase thioesterases catalyze rapid hydrolysis of peptidyl thioesters. Bioorganic & Medicinal Chemistry Letters. 19: 1413-5. PMID 19188064 DOI: 10.1016/J.Bmcl.2009.01.040 |
0.433 |
|
| 2009 |
Houghton SR, Furst L, Boddy CN. Biomimetic transannular oxa-conjugate addition approach to the 2,6-disubstituted dihydropyran of laulimalide yields an unprecedented transannular oxetane. The Journal of Organic Chemistry. 74: 1454-63. PMID 19159194 DOI: 10.1021/Jo8023494 |
0.705 |
|
| 2008 |
Wang M, Boddy CN. Examining the role of hydrogen bonding interactions in the substrate specificity for the loading step of polyketide synthase thioesterase domains. Biochemistry. 47: 11793-803. PMID 18850723 DOI: 10.1021/Bi800963Y |
0.411 |
|
| 2007 |
Zhang W, Wilke BI, Zhan J, Watanabe K, Boddy CN, Tang Y. A new mechanism for benzopyrone formation in aromatic polyketide biosynthesis. Journal of the American Chemical Society. 129: 9304-5. PMID 17625867 DOI: 10.1021/Ja0736919 |
0.733 |
|
| 2007 |
Lundgren BR, Boddy CN. Sialic acid and N-acyl sialic acid analog production by fermentation of metabolically and genetically engineered Escherichia coli. Organic & Biomolecular Chemistry. 5: 1903-9. PMID 17551639 DOI: 10.1039/B703519E |
0.325 |
|
| 2007 |
Sharma KK, Boddy CN. The thioesterase domain from the pimaricin and erythromycin biosynthetic pathways can catalyze hydrolysis of simple thioester substrates. Bioorganic & Medicinal Chemistry Letters. 17: 3034-7. PMID 17428661 DOI: 10.1016/J.Bmcl.2007.03.060 |
0.412 |
|
| 2006 |
Watanabe K, Hotta K, Praseuth AP, Koketsu K, Migita A, Boddy CN, Wang CC, Oguri H, Oikawa H. Total biosynthesis of antitumor nonribosomal peptides in Escherichia coli. Nature Chemical Biology. 2: 423-8. PMID 16799553 DOI: 10.1038/Nchembio803 |
0.611 |
|
| 2004 |
Boddy CN, Hotta K, Tse ML, Watts RE, Khosla C. Precursor-directed biosynthesis of epothilone in Escherichia coli. Journal of the American Chemical Society. 126: 7436-7. PMID 15198579 DOI: 10.1021/Ja048108S |
0.56 |
|
| 2003 |
Watanabe K, Wang CC, Boddy CN, Cane DE, Khosla C. Understanding substrate specificity of polyketide synthase modules by generating hybrid multimodular synthases. The Journal of Biological Chemistry. 278: 42020-6. PMID 12923197 DOI: 10.1074/Jbc.M305339200 |
0.66 |
|
| 2003 |
Boddy CN, Schneider TL, Hotta K, Walsh CT, Khosla C. Epothilone C macrolactonization and hydrolysis are catalyzed by the isolated thioesterase domain of epothilone polyketide synthase. Journal of the American Chemical Society. 125: 3428-9. PMID 12643694 DOI: 10.1021/Ja0298646 |
0.489 |
|
| 2002 |
Nicolaou KC, Boddy CN. Atropselective macrocyclization of diaryl ether ring systems: application to the synthesis of vancomycin model systems. Journal of the American Chemical Society. 124: 10451-5. PMID 12197747 DOI: 10.1021/Ja020736R |
0.415 |
|
| 1999 |
Nicolaou KC, Boddy CN, Bräse S, Winssinger N. Chemistry, Biology, and Medicine of the Glycopeptide Antibiotics. Angewandte Chemie (International Ed. in English). 38: 2096-2152. PMID 10425471 DOI: 10.1002/(Sici)1521-3773(19990802)38:15<2096::Aid-Anie2096>3.0.Co;2-F |
0.6 |
|
| 1995 |
Clive DLJ, Tao Y, Khodabocus A, Wu YJ, Angoh AG, Bennett SM, Boddy CN, Bordeleau L, Cantin M, Cheshire DR, Kellner D, Kleiner G, Middleton DS, Nichols CJ, Richardson SR, et al. Total synthesis of crystalline (±)-fredericamycin A Studies in Natural Products Chemistry. 16: 27-74. DOI: 10.1016/S1572-5995(06)80052-9 |
0.316 |
|
| 1994 |
Clive DLJ, Tao Y, Khodabocus A, Wu Y, Angoh AG, Bennett SM, Boddy CN, Bordeleau L, Kellner D. Total Synthesis of Crystalline (.+-.)-Fredericamycin A. Use of Radical Spirocyclization Journal of the American Chemical Society. 116: 11275-11286. DOI: 10.1021/Ja00104A009 |
0.319 |
|
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