Patrick M. Kochanek - Publications

Affiliations: 
University of Pittsburgh, Pittsburgh, PA, United States 

499 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Treble-Barna A, Petersen BA, Stec Z, Conley YP, Fink EL, Kochanek PM. Brain-Derived Neurotrophic Factor in Pediatric Acquired Brain Injury and Recovery. Biomolecules. 14. PMID 38397427 DOI: 10.3390/biom14020191  0.387
2023 McNamara CR, Kalinowski A, Horvat CM, Gaines BA, Richardson WM, Simon DW, Kochanek PM, Berger RP, Fink EL. New Functional Impairment After Hospital Discharge by Traumatic Brain Injury Mechanism in Younger Than 3 Years Old Admitted to the PICU in a Single Center Retrospective Study. Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. PMID 38088760 DOI: 10.1097/PCC.0000000000003417  0.358
2023 McNamara CR, Even KM, Kalinowski A, Horvat CM, Gaines BA, Richardson WM, Simon DW, Kochanek PM, Berger RP, Fink EL. Multiorgan Dysfunction Syndrome in Abusive and Accidental Pediatric Traumatic Brain Injury. Neurocritical Care. PMID 38062303 DOI: 10.1007/s12028-023-01887-y  0.335
2023 Jha RM, Kochanek PM. Physiological trajectories after traumatic brain injury: markers or makers of disease? The Lancet. Neurology. PMID 37977158 DOI: 10.1016/S1474-4422(23)00428-3  0.366
2023 Diaz-Arrastia R, Kochanek PM. Pharmacotherapy for Traumatic Brain Injury: The Next Generation of Clinical Trials. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 37698808 DOI: 10.1007/s13311-023-01438-5  0.347
2023 Clark RSB, Empey PE, Kochanek PM, Bell MJ. N-Acetylcysteine and Probenecid Adjuvant Therapy for Traumatic Brain Injury. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 37596428 DOI: 10.1007/s13311-023-01422-z  0.351
2023 Kochanek PM, Herrmann JR, Bleck TP. The Evolution of Ketamine in Severe Pediatric Traumatic Brain Injury, From Contraband to Promising Neuroprotectant? Critical Care Medicine. 51: 677-680. PMID 37052437 DOI: 10.1097/CCM.0000000000005826  0.412
2023 Cummings J, Wu YL, Dixon CE, Henchir J, Simard JM, Panigrahy A, Kochanek PM, Jha RM, Aneja RK. Abcc8 (sulfonylurea receptor-1) knockout mice exhibit reduced axonal injury, cytotoxic edema and cognitive dysfunction vs. wild-type in a cecal ligation and puncture model of sepsis. Journal of Neuroinflammation. 20: 12. PMID 36681815 DOI: 10.1186/s12974-023-02692-2  0.303
2022 Zusman BE, Wu Y, Kochanek PM, Vagni VE, Janesko-Feldman K, Gerzanich V, Simard JM, Karahalios K, Mihaljevic S, Raikwar S, Rani A, Rulney J, Desai SM, Catapano J, Jha RM. Precision Effects of Glibenclamide on MRI Endophenotypes in Clinically Relevant Murine Traumatic Brain Injury. Critical Care Medicine. 51: e45-e59. PMID 36661464 DOI: 10.1097/CCM.0000000000005749  0.353
2022 Jackson TC, Dezfulian C, Vagni VA, Stezoski J, Janesko-Feldman K, Kochanek PM. PHLPP Inhibitor NSC74429 Is Neuroprotective in Rodent Models of Cardiac Arrest and Traumatic Brain Injury. Biomolecules. 12. PMID 36291561 DOI: 10.3390/biom12101352  0.362
2022 Rakkar J, Azar J, Pelletier JH, Au AK, Bell MJ, Simon DW, Kochanek PM, Clark RSB, Horvat CM. Temporal Patterns in Brain Tissue and Systemic Oxygenation Associated with Mortality After Severe Traumatic Brain Injury in Children. Neurocritical Care. PMID 36171518 DOI: 10.1007/s12028-022-01602-3  0.322
2022 Raees M, Hooli S, von Saint André-von Arnim AO, Laeke T, Otupiri E, Fabio A, Rudd KE, Kumar R, Wilson PT, Aklilu AT, Tuyisenge L, Wang C, Tasker RC, Angus DC, Kochanek PM, et al. An exploratory assessment of the management of pediatric traumatic brain injury in three centers in Africa. Frontiers in Pediatrics. 10: 936150. PMID 36061402 DOI: 10.3389/fped.2022.936150  0.349
2022 Bell MJ, Rosario BL, Kochanek PM, Adelson PD, Morris KP, Au AK, Schober M, Butt W, Edwards RJ, Zimmerman J, Pineda J, Le TM, Dean N, Whalen MJ, Figaji A, et al. Comparative Effectiveness of Diversion of Cerebrospinal Fluid for Children With Severe Traumatic Brain Injury. Jama Network Open. 5: e2220969. PMID 35802371 DOI: 10.1001/jamanetworkopen.2022.20969  0.373
2022 Mondello S, Sandner V, Goli M, Czeiter E, Amrein K, Kochanek PM, Gautam S, Cho BG, Morgan R, Nehme A, Fiumara G, Eid AH, Barsa C, Haidar MA, Buki A, et al. Exploring serum glycome patterns after moderate to severe traumatic brain injury: A prospective pilot study. Eclinicalmedicine. 50: 101494. PMID 35755600 DOI: 10.1016/j.eclinm.2022.101494  0.624
2022 Rogers MB, Simon D, Firek B, Silfies L, Fabio A, Bell MJ, Yeh A, Azar J, Cheek R, Kochanek PM, Peddada SD, Morowitz MJ. Temporal and Spatial Changes in the Microbiome Following Pediatric Severe Traumatic Brain Injury. Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. PMID 35283451 DOI: 10.1097/PCC.0000000000002929  0.355
2022 Kochanek PM, Adelson PD, Rosario BL, Hutchison J, Miller Ferguson N, Ferrazzano P, O'Brien N, Beca J, Sarnaik A, LaRovere K, Bennett TD, Deep A, Gupta D, Willyerd FA, Gao S, et al. Comparison of Intracranial Pressure Measurements Before and After Hypertonic Saline or Mannitol Treatment in Children With Severe Traumatic Brain Injury. Jama Network Open. 5: e220891. PMID 35267036 DOI: 10.1001/jamanetworkopen.2022.0891  0.373
2021 Jha RM, Zusman BE, Puccio AM, Okonkwo DO, Pease M, Desai SM, Leach M, Conley YP, Kochanek PM. Genetic Variants Associated With Intraparenchymal Hemorrhage Progression After Traumatic Brain Injury. Jama Network Open. 4: e2116839. PMID 34309670 DOI: 10.1001/jamanetworkopen.2021.16839  0.344
2021 Kochanek PM, Jha RM. Fluid therapy after brain injury: the pendulum swings again. The Lancet. Neurology. 20: 587-589. PMID 34302775 DOI: 10.1016/S1474-4422(21)00204-0  0.358
2021 Smith DH, Kochanek PM, Rosi S, Meyer R, Ferland-Beckham C, Prager EM, Ahlers S, Crawford FC. Roadmap for Advancing Preclinical Science in Traumatic Brain Injury. Journal of Neurotrauma. PMID 34210174 DOI: 10.1089/neu.2021.0094  0.331
2021 Soysal E, Horvat CM, Simon DW, Wolf MS, Tyler-Kabara E, Gaines BA, Clark RSB, Kochanek PM, Bayir H. Clinical Deterioration and Neurocritical Care Utilization in Pediatric Patients With Glasgow Coma Scale Score of 9-13 After Traumatic Brain Injury: Associations With Patient and Injury Characteristics. Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. PMID 34038066 DOI: 10.1097/PCC.0000000000002767  0.396
2021 Osier N, Bramlett HM, Shear DA, Mondello S, Carlson SW, Dietrich WD, Deng-Bryant Y, Wang KKW, Hayes RL, Yang Z, Empey PE, Poloyac SM, Lafrenaye AD, Povlishock J, Gilsdorf J, ... Kochanek PM, et al. Kollidon VA64 Treatment in Traumatic Brain Injury, Operation Brain Trauma Therapy. Journal of Neurotrauma. PMID 33843262 DOI: 10.1089/neu.2021.0089  0.715
2021 Zusman BE, Kochanek PM, Bell MJ, Adelson PD, Wisniewski SR, Au A, Clark RS, Bayir H, Janesko-Feldman K, Jha RM. Cerebrospinal fluid Sulfonylurea Receptor-1 is associated with intracranial pressure and outcome after pediatric TBI-an exploratory analysis of the Cool Kids Trial. Journal of Neurotrauma. PMID 33430695 DOI: 10.1089/neu.2020.7501  0.354
2020 Lafrenaye A, Mondello S, Povlishock J, Gorse K, Walker S, Hayes R, Wang K, Kochanek PM. Operation Brain Trauma Therapy: An Exploratory Study of Levetiracetam Treatment Following Mild Traumatic Brain Injury in the Micro Pig. Frontiers in Neurology. 11: 586958. PMID 33584493 DOI: 10.3389/fneur.2020.586958  0.727
2020 Nacoti M, Fazzi F, Biroli F, Zangari R, Barbui T, Kochanek PM. Addressing Key Clinical Care and Clinical Research Needs in Severe Pediatric Traumatic Brain Injury: Perspectives From a Focused International Conference. Frontiers in Pediatrics. 8: 594425. PMID 33537259 DOI: 10.3389/fped.2020.594425  0.324
2020 Jha R, Mondello S, Bramlett HM, Dixon CE, Shear DA, Dietrich WD, Wang KKW, Yang Z, Hayes RL, Poloyac SM, Empey PE, Lafrenaye AD, Yan HQ, Carlson SW, Povlishock J, ... ... Kochanek PM, et al. Glibenclamide Treatment in Traumatic Brain Injury-Operation Brain Trauma Therapy. Journal of Neurotrauma. PMID 33203303 DOI: 10.1089/neu.2020.7421  0.725
2020 DeKosky ST, Kochanek PM, Valadka A, Clark RSB, Chou SHY, Au A, Horvat CM, Jha RM, Mannix R, Wisniewski SR, Wintermark M, Rowell SE, Welch RD, Lewis LM, House S, et al. Blood Biomarkers for Detection of Brain Injury in COVID-19 Patients. Journal of Neurotrauma. PMID 33115334 DOI: 10.1089/neu.2020.7332  0.36
2020 Bailey ZS, Leung LY, Yang X, Cardiff K, Gilsdorf J, Shear D, Kochanek PM. Pre-Hospital Whole Blood Resuscitation Reduces Fluid Requirement While Maintaining Critical Physiology in a Model of Penetrating Traumatic Brain Injury and Hemorrhage: Implications on Resource-Limited Combat Casualty Care. Shock (Augusta, Ga.). PMID 32925600 DOI: 10.1097/Shk.0000000000001662  0.437
2020 Zusman BE, Kochanek PM, Bailey ZS, Leung LY, Vagni VA, Okonkwo DO, Puccio AM, Shutter LA, Janesko-Feldman KL, Gilsdorf JS, Shear DA, Jha RM. Multifaceted Benefit of Whole Blood Versus Lactated Ringer's Resuscitation After Traumatic Brain Injury and Hemorrhagic Shock in Mice. Neurocritical Care. PMID 32886294 DOI: 10.1007/S12028-020-01084-1  0.465
2020 Simon DW, Rogers MB, Gao Y, Vincent G, Firek BA, Janesko-Feldman K, Vagni V, Kochanek PM, Ozolek JA, Mollen KP, Clark RSB, Morowitz MJ. Depletion of Gut Microbiota is Associated with Improved Neurologic Outcome Following Traumatic Brain Injury. Brain Research. 147056. PMID 32798452 DOI: 10.1016/J.Brainres.2020.147056  0.398
2020 Lafrenaye AD, Mondello S, Wang KK, Yang Z, Povlishock JT, Gorse K, Walker S, Hayes RL, Kochanek PM. Circulating GFAP and Iba-1 levels are associated with pathophysiological sequelae in the thalamus in a pig model of mild TBI. Scientific Reports. 10: 13369. PMID 32770054 DOI: 10.1038/S41598-020-70266-W  0.724
2020 Jackson TC, Kochanek PM. RNA Binding Motif 5 (RBM5) in the CNS-Moving Beyond Cancer to Harness RNA Splicing to Mitigate the Consequences of Brain Injury. Frontiers in Molecular Neuroscience. 13: 126. PMID 32765218 DOI: 10.3389/Fnmol.2020.00126  0.379
2020 Fink EL, Wisnowski J, Clark R, Berger RP, Fabio A, Furtado A, Narayan S, Angus DC, Watson RS, Wang C, Callaway CW, Bell MJ, Kochanek PM, Bluml S, Panigrahy A. Brain MR imaging and spectroscopy for outcome prognostication after pediatric cardiac arrest. Resuscitation. PMID 32653571 DOI: 10.1016/J.Resuscitation.2020.06.033  0.323
2020 Treble-Barna A, Patronick J, Uchani S, Marousis NC, Zigler CK, Fink EL, Kochanek PM, Conley YP, Yeates KO. Epigenetic Effects on Pediatric Traumatic Brain Injury Recovery (EETR): An Observational, Prospective, Longitudinal Concurrent Cohort Study Protocol. Frontiers in Neurology. 11: 460. PMID 32595586 DOI: 10.3389/Fneur.2020.00460  0.481
2020 Wolf MS, Rakkar J, Horvat CM, Simon DW, Kochanek PM, Clermont G, Clark RSB. Assessment of Dynamic Intracranial Compliance in Children with Severe Traumatic Brain Injury: Proof-of-Concept. Neurocritical Care. PMID 32556856 DOI: 10.1007/S12028-020-01004-3  0.424
2020 Even KM, Subramanian S, Berger RP, Kochanek PM, Zuccoli G, Gaines BA, Fink EL. The Presence of Anemia in Children with Abusive Head Trauma. The Journal of Pediatrics. PMID 32532650 DOI: 10.1016/J.Jpeds.2020.04.008  0.429
2020 Jackson TC, Janesko-Feldman K, Gorse K, Vagni VA, Jackson EK, Kochanek PM. Identification of novel targets of RBM5 in the healthy and injured brain. Neuroscience. PMID 32335213 DOI: 10.1016/J.Neuroscience.2020.04.024  0.404
2020 Pang D, Wu Y, Alcamo A, Cummings J, Caro VD, Walko T, Hsue V, Clark R, Panigrahy A, Kochanek P, Aneja R. 1691: Axonal Injury, Cytotoxic Cerebral Edema, And Microglial Activation In A Mouse Model Of Sepsis Critical Care Medicine. 48: 820. DOI: 10.1097/01.Ccm.0000648664.77079.5B  0.366
2020 Wolf M, Rakkar J, Horvat C, Simon D, Kochanek P, Clermont G, Clark R. 690: Dynamic Assessment Of Intracranial Compliance In Pediatric Traumatic Brain Injury Critical Care Medicine. 48: 325. DOI: 10.1097/01.Ccm.0000626500.44446.6F  0.474
2020 Gretchen C, Bayir H, Kochanek P, Kim-Campbell N. 202: Hyperoxia And Severe Hemolysis In Pediatric Cardiopulmonary Bypass Critical Care Medicine. 48: 83. DOI: 10.1097/01.Ccm.0000619164.46450.Db  0.3
2020 Munjal N, Clark R, Simon D, Kochanek P, Horvat C. 38: Machine Learning Predicting Mortality And Morbidity In Children With Neurologic Injury In The Picu Critical Care Medicine. 48: 19. DOI: 10.1097/01.Ccm.0000618652.25630.B6  0.32
2020 Zusman BE, Kochanek PM, Jha RM. Cerebral Edema in Traumatic Brain Injury: a Historical Framework for Current Therapy Current Treatment Options in Neurology. 22. DOI: 10.1007/S11940-020-0614-X  0.48
2019 Janata A, Magnet IA, Schreiber KL, Wilson CD, Stezoski JP, Janesko-Feldman K, Kochanek PM, Drabek T. Minocycline fails to improve neurologic and histologic outcome after ventricular fibrillation cardiac arrest in rats. World Journal of Critical Care Medicine. 8: 106-119. PMID 31853446 DOI: 10.5492/Wjccm.V8.I7.106  0.335
2019 Lumba-Brown A, Totten A, Kochanek PM. Emergency Department Implementation of the Brain Trauma Foundation's Pediatric Severe Brain Injury Guideline Recommendations. Pediatric Emergency Care. PMID 31804428 DOI: 10.1097/Pec.0000000000001903  0.486
2019 Jackson TC, Janesko-Feldman K, Carlson SW, Kotermanski SE, Kochanek PM. Robust RBM3 and β-klotho expression in developing neurons in the human brain. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X19878889. PMID 31566073 DOI: 10.1177/0271678X19878889  0.333
2019 Uray T, Empey PE, Drabek T, Stezoski JP, Janesko-Feldman K, Jackson T, Garman RH, Kim F, Kochanek PM, Dezfulian C. Nitrite pharmacokinetics, safety and efficacy after experimental ventricular fibrillation cardiac arrest. Nitric Oxide : Biology and Chemistry. PMID 31526855 DOI: 10.1016/J.Niox.2019.09.003  0.352
2019 Bell MJ, Kochanek PM. International traumatic brain injury research: an annus mirabilis? The Lancet. Neurology. 18: 904-905. PMID 31526746 DOI: 10.1016/S1474-4422(19)30289-3  0.473
2019 Pang D, Wu YL, Alcamo AM, Cummings J, Di Caro V, Walko T, Hsue V, Clark RSB, Panigrahy A, Kochanek PM, Aneja RK. Early Axonal Injury and Delayed Cytotoxic Cerebral Edema are Associated With Microglial Activation in a Mouse Model of Sepsis. Shock (Augusta, Ga.). PMID 31513049 DOI: 10.1097/Shk.0000000000001446  0.48
2019 Anthonymuthu TS, Kenny EM, Hier ZE, Clark RSB, Kochanek PM, Kagan VE, Bayır H. Detection of brain specific cardiolipins in plasma after experimental pediatric head injury. Experimental Neurology. PMID 30981805 DOI: 10.1016/J.Expneurol.2019.04.007  0.462
2019 Kochanek PM, Tasker RC, Carney N, Totten AM, Adelson PD, Selden NR, Davis-O'Reilly C, Hart EL, Bell MJ, Bratton SL, Grant GA, Kissoon N, Reuter-Rice KE, Vavilala MS, Wainwright MS. Guidelines for the Management of Pediatric Severe Traumatic Brain Injury, Third Edition: Update of the Brain Trauma Foundation Guidelines, Executive Summary. Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 20: 280-289. PMID 30830016 DOI: 10.1097/Pcc.0000000000001736  0.483
2019 Kochanek PM, Tasker RC, Bell MJ, Adelson PD, Carney N, Vavilala MS, Selden NR, Bratton SL, Grant GA, Kissoon N, Reuter-Rice KE, Wainwright MS. Management of Pediatric Severe Traumatic Brain Injury: 2019 Consensus and Guidelines-Based Algorithm for First and Second Tier Therapies. Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 20: 269-279. PMID 30830015 DOI: 10.1097/Pcc.0000000000001737  0.441
2019 Kochanek PM, Tasker RC, Carney N, Totten AM, Adelson PD, Selden NR, Davis-O'Reilly C, Hart EL, Bell MJ, Bratton SL, Grant GA, Kissoon N, Reuter-Rice KE, Vavilala MS, Wainwright MS. Guidelines for the Management of Pediatric Severe Traumatic Brain Injury, Third Edition: Update of the Brain Trauma Foundation Guidelines. Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 20: S1-S82. PMID 30829890 DOI: 10.1097/Pcc.0000000000001735  0.494
2019 Kochanek PM, Tasker RC, Carney N, Totten AM, Adelson PD, Selden NR, Davis-O'Reilly C, Hart EL, Bell MJ, Bratton SL, Grant GA, Kissoon N, Reuter-Rice KE, Vavilala MS, Wainwright MS. Guidelines for the Management of Pediatric Severe Traumatic Brain Injury, Third Edition: Update of the Brain Trauma Foundation Guidelines, Executive Summary. Neurosurgery. PMID 30822776 DOI: 10.1093/Neuros/Nyz051  0.419
2019 Hagos FT, Adams SM, Poloyac SM, Kochanek PM, Horvat CM, Clark RSB, Empey PE. Membrane transporters in traumatic brain injury: Pathological, pharmacotherapeutic, and developmental implications. Experimental Neurology. PMID 30797827 DOI: 10.1016/J.Expneurol.2019.02.011  0.418
2019 Chao H, Lin C, Zuo Q, Liu Y, Xiao M, Xu X, Li Z, Bao Z, Chen H, You Y, Kochanek PM, Yin H, Liu N, Kagan VE, Bayır H, et al. Cardiolipin-dependent mitophagy guides outcome after traumatic brain injury. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 30626699 DOI: 10.1523/Jneurosci.3415-17.2018  0.394
2019 Soysal E, Horvat C, Simon D, Kochanek P, Clark R, Bayir H. 1811: Predictors Of Deterioration And Neurocritical Care Use In Pediatric Moderate Traumatic Brain Injury Critical Care Medicine. 47: 879. DOI: 10.1097/01.Ccm.0000552549.96071.1C  0.475
2018 Kenny EM, Fidan E, Yang Q, Anthonymuthu TS, New LA, Meyer EA, Wang H, Kochanek PM, Dixon CE, Kagan VE, Bayır H. Ferroptosis Contributes to Neuronal Death and Functional Outcome After Traumatic Brain Injury. Critical Care Medicine. PMID 30531185 DOI: 10.1097/Ccm.0000000000003555  0.472
2018 Kochanek PM, Jackson TC, Jha R, Clark RSB, Okonkwo DO, Bayir H, Poloyac SM, Wagner AK, Empey PE, Conley YP, Bell MJ, Kline AE, Bondi CO, Simon DW, Carlson SW, et al. Paths to successful translation of new therapies for severe TBI in the golden age of traumatic brain injury research: A Pittsburgh vision. Journal of Neurotrauma. PMID 30520681 DOI: 10.1089/Neu.2018.6203  0.406
2018 Jha RM, Kochanek PM. A Precision Medicine Approach to Cerebral Edema and Intracranial Hypertension after Severe Traumatic Brain Injury: Quo Vadis? Current Neurology and Neuroscience Reports. 18: 105. PMID 30406315 DOI: 10.1007/S11910-018-0912-9  0.405
2018 Jackson TC, Kotermanski SE, Kochanek PM. Infants Uniquely Express High Levels of RBM3 and Other Cold-Adaptive Neuroprotectant Proteins in the Human Brain. Developmental Neuroscience. 1-12. PMID 30399610 DOI: 10.1159/000493637  0.352
2018 Jackson TC, Kotermanski SE, Kochanek PM, Jackson EK. Oxidative Stress Induces Release of 2'-AMP from Microglia. Brain Research. PMID 30395838 DOI: 10.1016/J.Brainres.2018.11.002  0.396
2018 Wallisch JS, Janesko-Feldman K, Alexander H, Jha RM, Farr GW, McGuirk PR, Kline AE, Jackson TC, Pelletier MF, Clark RSB, Kochanek PM, Manole MD. The aquaporin-4 inhibitor AER-271 blocks acute cerebral edema and improves early outcome in a pediatric model of asphyxial cardiac arrest. Pediatric Research. PMID 30367162 DOI: 10.1038/S41390-018-0215-5  0.348
2018 Kochanek PM, Dixon CE, Mondello S, Wang KKK, Lafrenaye A, Bramlett HM, Dietrich WD, Hayes RL, Shear DA, Gilsdorf JS, Catania M, Poloyac SM, Empey PE, Jackson TC, Povlishock JT. Multi-Center Pre-clinical Consortia to Enhance Translation of Therapies and Biomarkers for Traumatic Brain Injury: Operation Brain Trauma Therapy and Beyond. Frontiers in Neurology. 9: 640. PMID 30131759 DOI: 10.3389/Fneur.2018.00640  0.725
2018 Jha RM, Elmer J, Zusman BE, Desai S, Puccio AM, Okonkwo DO, Park SY, Shutter LA, Wallisch JS, Conley YP, Kochanek PM. Intracranial Pressure Trajectories: A Novel Approach to Informing Severe Traumatic Brain Injury Phenotypes. Critical Care Medicine. PMID 30119071 DOI: 10.1097/Ccm.0000000000003361  0.455
2018 Jha RM, Kochanek PM, Simard JM. Pathophysiology and treatment of cerebral edema in traumatic brain injury. Neuropharmacology. PMID 30086289 DOI: 10.1016/J.Neuropharm.2018.08.004  0.454
2018 Aneja RK, Alcamo A, Cummings JL, Vagni VA, Janesko-Feldman KL, Wang Q, Dixon CE, Billiar T, Kochanek PM. Lack of Benefit on Brain Edema, Blood-Brain Barrier Permeability or Cognitive Outcome in Global, Inducible HMGB1 Knockout Mice despite Tissue Sparing after Experimental Traumatic Brain Injury. Journal of Neurotrauma. PMID 30045665 DOI: 10.1089/Neu.2018.5664  0.478
2018 Yang Z, Zhu T, Mondello S, Akel M, Wong AT, Kothari IM, Lin F, Shear DA, Gilsdorf J, Leung LY, Bramlett HM, Dixon CE, Dietrich WD, Hayes RL, Povlishock J, ... ... Kochanek PM, et al. Serum-based phospho-neurofilament-heavy protein as theranostic biomarker in three models of traumatic brain injury: an Operation Brain Trauma Therapy (OBTT) study. Journal of Neurotrauma. PMID 29987972 DOI: 10.1089/Neu.2017.5586  0.748
2018 Rakholia MV, Kumar RG, Oh BM, Ranganathan PR, Berga S, Kochanek PM, Wagner AK. Systemic estrone production and injury induced sex hormone steroidogenesis after severe traumatic brain injury: a prognostic indicator of TBI-related mortality. Journal of Neurotrauma. PMID 29947289 DOI: 10.1089/Neu.2018.5782  0.322
2018 Morrison AM, Houtrow A, Zullo J, Kochanek PM, Vetterly C, Fink EL. Neurostimulant prescribing patterns in children admitted to the ICU after traumatic brain injury. Journal of Neurotrauma. PMID 29756534 DOI: 10.1089/Neu.2017.5575  0.444
2018 DeWitt D, Hawkins BE, Dixon CE, Kochanek PM, Armstead WM, Bass C', Bramlett HM, Büki A, Dietrich WD, Ferguson AR, Hall ED, Hayes RL, Hinds Ii CSR, LaPlaca M, Long J, et al. Preclinical Testing of Therapies for Traumatic Brain Injury. Journal of Neurotrauma. PMID 29756522 DOI: 10.1089/Neu.2018.5778  0.632
2018 Hagos FT, Empey PE, Wang P, Ma X, Poloyac SM, Bayır H, Kochanek PM, Bell MJ, Clark RSB. Exploratory Application of Neuropharmacometabolomics in Severe Childhood Traumatic Brain Injury. Critical Care Medicine. PMID 29742587 DOI: 10.1097/Ccm.0000000000003203  0.46
2018 Fidan E, Foley LM, New LA, Alexander H, Kochanek PM, Hitchens TK, Bayır H. Metabolic and Structural Imaging at 7 Tesla After Repetitive Mild Traumatic Brain Injury in Immature Rats. Asn Neuro. 10: 1759091418770543. PMID 29741097 DOI: 10.1177/1759091418770543  0.419
2018 Jackson TC, Dixon CE, Janesko-Feldman K, Vagni V, Kotermanski SE, Jackson EK, Kochanek PM. Acute Physiology and Neurologic Outcomes after Brain Injury in SCOP/PHLPP1 KO Mice. Scientific Reports. 8: 7158. PMID 29739983 DOI: 10.1038/S41598-018-25371-2  0.466
2018 Wolf MS, Bayır H, Kochanek PM, Clark RSB. The role of autophagy in acute brain injury: A state of flux? Neurobiology of Disease. PMID 29704549 DOI: 10.1016/J.Nbd.2018.04.018  0.431
2018 Jha RM, Koleck TA, Puccio AM, Okonkwo DO, Park SY, Zusman BE, Clark RSB, Shutter LA, Wallisch JS, Empey PE, Kochanek PM, Conley YP. Regionally clustered polymorphisms in a prospective cohort predict cerebral oedema and outcome in severe traumatic brain injury. Journal of Neurology, Neurosurgery, and Psychiatry. PMID 29674479 DOI: 10.1136/Jnnp-2017-317741  0.448
2018 Fink EL, von Saint Andre-von Arnim A, Kumar R, Wilson PT, Bacha T, Aklilu AT, Teklemariam TL, Hooli S, Tuyisenge L, Otupiri E, Fabio A, Gianakas J, Kochanek PM, Angus DC, Tasker RC, et al. Traumatic Brain Injury and Infectious Encephalopathy in Children From Four Resource-Limited Settings in Africa. Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. PMID 29664874 DOI: 10.1097/Pcc.0000000000001554  0.451
2018 Jha R, Molyneaux BJ, Jackson TC, Wallisch J, Park SY, Poloyac SM, Vagni VA, Janesko-Feldman KL, Hoshitsuki K, Minnigh MB, Kochanek PM. Glibenclamide produces region-dependent effects on cerebral edema in a combined injury model of traumatic brain injury and hemorrhagic shock in mice. Journal of Neurotrauma. PMID 29648981 DOI: 10.1089/Neu.2016.4696  0.458
2018 Kochanek PM, Bramlett HM, Dixon CE, Dietrich WD, Mondello S, Wang KKW, Hayes RL, Lafrenaye A, Povlishock JT, Tortella FC, Poloyac SM, Empey P, Shear DA. Operation Brain Trauma Therapy: 2016 Update. Military Medicine. 183: 303-312. PMID 29635589 DOI: 10.1093/Milmed/Usx184  0.73
2018 Uray T, Lamade A, Elmer J, Drabek T, Stezoski JP, Missé A, Janesko-Feldman K, Garman RH, Chen N, Kochanek PM, Dezfulian C. Phenotyping Cardiac Arrest: Bench and Bedside Characterization of Brain and Heart Injury Based on Etiology. Critical Care Medicine. PMID 29533310 DOI: 10.1097/Ccm.0000000000003070  0.346
2018 Meinert E, Bell MJ, Buttram S, Kochanek PM, Balasubramani GK, Wisniewski SR, Adelson PD. Initiating Nutritional Support Before 72 Hours Is Associated With Favorable Outcome After Severe Traumatic Brain Injury in Children: A Secondary Analysis of a Randomized, Controlled Trial of Therapeutic Hypothermia. Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. PMID 29370008 DOI: 10.1097/Pcc.0000000000001471  0.47
2018 Simon D, McGeachy M, Raphael I, Vagni V, Kochanek P, Bayir H, Clark R. 1571: Role Of Il-17 After Traumatic Brain Injury In Adult Mice Critical Care Medicine. 46: 770. DOI: 10.1097/01.Ccm.0000529572.79638.24  0.41
2017 Jackson TC, Kotermanski SE, Jackson EK, Kochanek PM. BrainPhys® increases neurofilament levels in CNS cultures, and facilitates investigation of axonal damage after a mechanical stretch-injury in vitro. Experimental Neurology. 300: 232-246. PMID 29199132 DOI: 10.1016/J.Expneurol.2017.11.013  0.363
2017 Kochanek PM, Wallisch JS, Bayır H, Clark RSB. Pre-clinical models in pediatric traumatic brain injury-challenges and lessons learned. Child's Nervous System : Chns : Official Journal of the International Society For Pediatric Neurosurgery. 33: 1693-1701. PMID 29149385 DOI: 10.1007/S00381-017-3474-2  0.475
2017 Adams SM, Conley YP, Wagner AK, Jha RM, Clark RS, Poloyac SM, Kochanek PM, Empey PE. The pharmacogenomics of severe traumatic brain injury. Pharmacogenomics. PMID 28975867 DOI: 10.2217/Pgs-2017-0073  0.465
2017 Kim-Campbell N, Gretchen C, Callaway C, Felmet K, Kochanek PM, Maul T, Wearden P, Sharma M, Viegas M, Munoz R, Gladwin MT, Bayir H. Cell-Free Plasma Hemoglobin and Male Gender Are Risk Factors for Acute Kidney Injury in Low Risk Children Undergoing Cardiopulmonary Bypass. Critical Care Medicine. PMID 28863013 DOI: 10.1097/Ccm.0000000000002703  0.331
2017 Horvat CM, Kochanek PM. Big Data Not Yet Big Enough to Determine the Influence of Intracranial Pressure Monitoring on Outcome in Children With Severe Traumatic Brain Injury. Jama Pediatrics. PMID 28846750 DOI: 10.1001/Jamapediatrics.2017.2390  0.451
2017 Simon DW, McGeachy MJ, Bayır H, Clark RSB, Loane DJ, Kochanek PM. The far-reaching scope of neuroinflammation after traumatic brain injury. Nature Reviews. Neurology. PMID 28776601 DOI: 10.1038/nrneurol.2017.116  0.398
2017 Bosetti F, Koenig JI, Ayata C, Back SA, Becker K, Broderick JP, Carmichael ST, Cho S, Cipolla MJ, Corbett D, Corriveau RA, Cramer SC, Ferguson AR, Finklestein SP, Ford BD, ... ... Kochanek PM, et al. Translational Stroke Research: Vision and Opportunities. Stroke. PMID 28751554 DOI: 10.1161/Strokeaha.117.017112  0.3
2017 Adams SM, Conley YP, Ren D, Okonkwo DO, Puccio A, Dixon CE, Clark RS, Kochanek PM, Empey PE. ABCG2 c.421C>A is Associated with Outcomes Following Severe Traumatic Brain Injury. Journal of Neurotrauma. PMID 28747144 DOI: 10.1089/neu.2017.5000  0.301
2017 Jha RM, Kochanek PM. Adding insight to injury: a new era in neurotrauma. The Lancet. Neurology. 16: 578-580. PMID 28721915 DOI: 10.1016/S1474-4422(17)30225-9  0.357
2017 Simon DW, Aneja RK, Alexander H, Bell MJ, Bayir H, Kochanek PM, Clark RSB. Minocycline Attenuates High Mobility Group Box 1 Translocation, Microglial Activation, and Thalamic Neurodegeneration after Traumatic Brain Injury in Postnatal Day 17 Rats. Journal of Neurotrauma. PMID 28699371 DOI: 10.1089/neu.2017.5093  0.346
2017 Clark RSB, Empey PE, Bayır H, Rosario BL, Poloyac SM, Kochanek PM, Nolin TD, Au AK, Horvat CM, Wisniewski SR, Bell MJ. Phase I randomized clinical trial of N-acetylcysteine in combination with an adjuvant probenecid for treatment of severe traumatic brain injury in children. Plos One. 12: e0180280. PMID 28686657 DOI: 10.1371/Journal.Pone.0180280  0.478
2017 Au AK, Bell MJ, Fink EL, Aneja RK, Kochanek PM, Clark RSB. Brain-Specific Serum Biomarkers Predict Neurological Morbidity in Diagnostically Diverse Pediatric Intensive Care Unit Patients. Neurocritical Care. PMID 28612133 DOI: 10.1007/S12028-017-0414-7  0.388
2017 Kochanek PM, Bayir H. Titrating the dose of oxygen after severe traumatic brain injury in the era of precision medicine. Journal of Neurotrauma. PMID 28537530 DOI: 10.1089/Neu.2017.5159  0.449
2017 Miller Ferguson N, Sarnaik A, Miles D, Shafi N, Peters MJ, Truemper E, Vavilala MS, Bell MJ, Wisniewski SR, Luther JF, Hartman AL, Kochanek PM. Abusive Head Trauma and Mortality-An Analysis From an International Comparative Effectiveness Study of Children With Severe Traumatic Brain Injury. Critical Care Medicine. PMID 28430697 DOI: 10.1097/Ccm.0000000000002378  0.456
2017 Anthonymuthu TS, Kenny EM, Amoscato AA, Lewis J, Kochanek PM, Kagan VE, Bayır H. Global assessment of oxidized free fatty acids in brain reveals an enzymatic predominance to oxidative signaling after trauma. Biochimica Et Biophysica Acta. PMID 28347845 DOI: 10.1016/J.Bbadis.2017.03.015  0.332
2017 Jackson EK, Kotermanski SE, Menshikova EV, Dubey RK, Jackson TC, Kochanek PM. Adenosine Production by Brain Cells. Journal of Neurochemistry. PMID 28294336 DOI: 10.1111/Jnc.14018  0.337
2017 Wallisch JS, Kochanek PM. A "Metamorphosis" in Our Approach to Treatment Is Not Likely to Result From a Meta-Analysis of the Use of Therapeutic Hypothermia in Severe Traumatic Brain Injury. Critical Care Medicine. 45: 744-745. PMID 28291098 DOI: 10.1097/Ccm.0000000000002240  0.471
2017 Simon DW, McGeachy MJ, Bayır H, Clark RS, Loane DJ, Kochanek PM. The far-reaching scope of neuroinflammation after traumatic brain injury. Nature Reviews. Neurology. PMID 28186177 DOI: 10.1038/Nrneurol.2017.13  0.482
2017 Wallisch JS, Simon DW, Bayır H, Bell MJ, Kochanek PM, Clark RS. Cerebrospinal Fluid NLRP3 is Increased After Severe Traumatic Brain Injury in Infants and Children. Neurocritical Care. PMID 28181102 DOI: 10.1007/S12028-017-0378-7  0.468
2017 Griffith B, Kochanek P, Dezfulian C. The benefits of youth are lost on the young cardiac arrest patient. F1000research. 6: 77. PMID 28163912 DOI: 10.12688/F1000Research.9316.1  0.399
2017 Kochanek PM, Jackson TC. The Brain and Hypothermia-From Aristotle to Targeted Temperature Management. Critical Care Medicine. 45: 305-310. PMID 28098626 DOI: 10.1097/Ccm.0000000000002182  0.443
2017 Fabio A, Gao S, Bell M, Kochanek P, Wisniewski S. 97 Gunshot wounds to the head: the epidemiology of severe paediatric firearm-related traumatic brain injuries Injury Prevention. 23. DOI: 10.1136/Injuryprev-2017-042560.97  0.397
2016 Au AK, Aneja RK, Bayır H, Bell MJ, Janesko-Feldman K, Kochanek PM, Clark RS. Autophagy Biomarkers Beclin 1 and p62 are Increased in Cerebrospinal Fluid after Traumatic Brain Injury. Neurocritical Care. PMID 28000126 DOI: 10.1007/S12028-016-0351-X  0.452
2016 Brockman EC, Jackson TC, Dixon CE, Bayir H, Clark R, Vagni VA, Janesko KL, Byrd C, Ma L, Hsia CJ, Kochanek PM. POLYNITROXYLATED PEGYLATED HEMOGLOBIN: A NOVEL, SMALL VOLUME THERAPEUTIC FOR TRAUMATIC BRAIN INJURY RESUSCITATION: COMPARISON TO WHOLE BLOOD AND DOSE RESPONSE EVALUATION. Journal of Neurotrauma. PMID 27869558 DOI: 10.1089/neu.2016.4656  0.404
2016 Blennow K, Brody DL, Kochanek PM, Levin H, McKee A, Ribbers GM, Yaffe K, Zetterberg H. Traumatic brain injuries. Nature Reviews. Disease Primers. 2: 16084. PMID 27853132 DOI: 10.1038/nrdp.2016.84  0.35
2016 Woods K, Au A, Kochanek P, Bell M, Clark R. 775: SERUM BIOMARKER-BASED MODELS TO PREDICT INTRACRANIAL PRESSURE IN PEDIATRIC TRAUMATIC BRAIN INJURY. Critical Care Medicine. 44: 270. PMID 27850413 DOI: 10.1097/01.Ccm.0000509451.19080.45  0.446
2016 Simon D, Aneja R, New L, Vagni V, Bayir H, Morowitz M, Kochanek P, Clark R. 743: ACUTE INFLAMMATORY RESPONSE TO TRAUMATIC BRAIN INJURY IS AFFECTED BY MODULATORS OF GUT MICROBIOTA. Critical Care Medicine. 44: 262. PMID 27850381 DOI: 10.1097/01.Ccm.0000509419.49574.44  0.443
2016 Kenny E, Yang Q, Fidan E, Ann New L, Anthonymuthu TS, Kochanek P, Kagan V, Bayir H. 740: INHIBITION OF FERROPTOSIS AS A NEUROPROTECTIVE STRATEGY FOLLOWING TRAUMATIC BRAIN INJURY. Critical Care Medicine. 44: 261. PMID 27850378 DOI: 10.1097/01.Ccm.0000509416.82747.8D  0.49
2016 Jha R, Puccio A, Okonkwo D, Zusman B, Wallisch J, Shutter L, Kochanek P, Conley Y. 738: ABCC8 TAG SINGLE NUCLEOTIDE POLYMORPHISMS CORRELATE WITH EDEMA AND OUTCOME IN TRAUMATIC BRAIN INJURY. Critical Care Medicine. 44: 260. PMID 27850376 DOI: 10.1097/01.Ccm.0000509414.75123.25  0.444
2016 Horvat C, Bell M, Wisniewski S, Balasubramani G, Kochanek P, Beers S, Brown SD, Adelson P. 726: POST-RESUSCITATION GCS IS ASSOCIATED WITH OUTCOME IN PEDIATRIC SEVERE TRAUMATIC BRAIN INJURY. Critical Care Medicine. 44: 257. PMID 27850364 DOI: 10.1097/01.Ccm.0000509402.91263.A4  0.491
2016 Wallisch J, Jha R, Farr G, McGuirk P, Pelletier M, Jackson T, Kochanek P, Manole M. 718: AQUAPORIN-4 INHIBITOR AER-271 BLOCKS EARLY CEREBRAL EDEMA IN PEDIATRIC RAT ASPHYXIAL CARDIAC ARREST. Critical Care Medicine. 44: 255. PMID 27850356 DOI: 10.1097/01.Ccm.0000509394.12349.6B  0.302
2016 Jha RM, Puccio AM, Chou SH, Chang CH, Wallisch JS, Molyneaux BJ, Zusman BE, Shutter LA, Poloyac SM, Janesko-Feldman KL, Okonkwo DO, Kochanek PM. Sulfonylurea Receptor-1: A Novel Biomarker for Cerebral Edema in Severe Traumatic Brain Injury. Critical Care Medicine. PMID 27845954 DOI: 10.1097/Ccm.0000000000002079  0.481
2016 Jha RM, Puccio AM, Okonkwo DO, Zusman BE, Park SY, Wallisch J, Empey PE, Shutter LA, Clark RS, Kochanek PM, Conley YP. ABCC8 Single Nucleotide Polymorphisms are Associated with Cerebral Edema in Severe TBI. Neurocritical Care. PMID 27677908 DOI: 10.1007/S12028-016-0309-Z  0.375
2016 Foley LM, Clark RS, Vazquez AL, Hitchens TK, Alexander H, Ho C, Kochanek PM, Manole MD. Enduring Disturbances in Regional Cerebral Blood Flow and Brain Oxygenation at 24 Hours after Asphyxial Cardiac Arrest in Developing Rats. Pediatric Research. PMID 27636898 DOI: 10.1038/Pr.2016.175  0.311
2016 Simon DW, Vagni VM, Kochanek PM, Clark RS. Combined Neurotrauma Models: Experimental Models Combining Traumatic Brain Injury and Secondary Insults. Methods in Molecular Biology (Clifton, N.J.). 1462: 393-411. PMID 27604730 DOI: 10.1007/978-1-4939-3816-2_22  0.474
2016 Sparvero LJ, Amoscato AA, Fink AB, Anthonymuthu T, New LE, Kochanek PM, Watkins S, Kagan VE, Bayır H. Imaging Mass Spectrometry Reveals Loss of Polyunsaturated Cardiolipins in the Cortical Contusion, Hippocampus and Thalamus after Traumatic Brain Injury. Journal of Neurochemistry. PMID 27591733 DOI: 10.1111/Jnc.13840  0.43
2016 Dezfulian C, Kenny E, Lamade A, Misse A, Krehel N, St Croix C, Kelley EE, Jackson TC, Uray T, Rackley J, Kochanek PM, Clark RS, Bayir H. Mechanistic characterization of nitrite-mediated neuroprotection after experimental cardiac arrest. Journal of Neurochemistry. PMID 27507435 DOI: 10.1111/Jnc.13764  0.38
2016 Kochanek P, Kitagawa RS, Batchelor P, Thoresen M. Central Nervous System Injury and Temperature Management. Therapeutic Hypothermia and Temperature Management. 6: 112-115. PMID 27447753 DOI: 10.1089/Ther.2016.29014.Pjk  0.365
2016 Berger RP, Fromkin J, Herman B, Pierce MC, Saladino RA, Flom L, Tyler-Kabara EC, McGinn T, Richichi R, Kochanek PM. Validation of the Pittsburgh Infant Brain Injury Score for Abusive Head Trauma. Pediatrics. PMID 27338699 DOI: 10.1542/Peds.2015-3756  0.39
2016 Mondello S, Kobeissy F, Vestri A, Hayes RL, Kochanek PM, Berger RP. Serum Concentrations of Ubiquitin C-Terminal Hydrolase-L1 and Glial Fibrillary Acidic Protein after Pediatric Traumatic Brain Injury. Scientific Reports. 6: 28203. PMID 27319802 DOI: 10.1038/Srep28203  0.637
2016 Hagos FT, Daood MJ, Ocque JA, Nolin TD, Bayir H, Poloyac SM, Kochanek PM, Clark RS, Empey PE. Probenecid, an organic anion transporter 1 and 3 inhibitor, increases plasma and brain exposure of N-acetylcysteine. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 1-8. PMID 27278858 DOI: 10.1080/00498254.2016.1187777  0.342
2016 Batchelor P, Dietrich WD, Kochanek PM, Lundbye J. Secondary Changes After Injury and Temperature. Therapeutic Hypothermia and Temperature Management. PMID 27249580 DOI: 10.1089/Ther.2016.29013.Pjb  0.37
2016 Miller Ferguson N, Shein SL, Kochanek PM, Luther J, Wisniewski SR, Clark RS, Tyler-Kabara EC, Adelson PD, Bell MJ. Intracranial Hypertension and Cerebral Hypoperfusion in Children With Severe Traumatic Brain Injury: Thresholds and Burden in Accidental and Abusive Insults. Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. PMID 27028792 DOI: 10.1097/Pcc.0000000000000709  0.438
2016 Wiley CA, Bissel SJ, Lesniak A, Dixon CE, Franks J, Stolz DB, Sun M, Wang G, Switzer Iii RC, Kochanek PM, Murdoch GH. Ultrastructure of diaschisis lesions following traumatic brain injury. Journal of Neurotrauma. PMID 26914973 DOI: 10.1089/Neu.2015.4272  0.392
2016 Fink EL, Berger RP, Clark RS, Watson RS, Angus DC, Panigrahy A, Richichi R, Callaway CW, Bell MJ, Mondello S, Hayes RL, Kochanek PM. Exploratory Study of Serum Ubiquitin Carboxyl-Terminal Esterase L1 and Glial Fibrillary Acidic Protein for Outcome Prognostication after Pediatric Cardiac Arrest. Resuscitation. PMID 26855294 DOI: 10.1016/J.Resuscitation.2016.01.024  0.615
2016 Du L, Empey P, Ji J, Chao H, Kochanek PM, Bayir H, Clark R. Probenecid and N-acetylcysteine Prevent Loss of Intracellular Glutathione and Inhibit Neuronal Death after Mechanical Stretch Injury In Vitro. Journal of Neurotrauma. PMID 26830358 DOI: 10.1089/Neu.2015.4342  0.354
2016 Jackson EK, Boison D, Schwarzschild MA, Kochanek PM. Purines: forgotten mediators in traumatic brain injury. Journal of Neurochemistry. 137: 142-53. PMID 26809224 DOI: 10.1111/Jnc.13551  0.494
2016 Kochanek PM, Clark RS. Traumatic brain injury research highlights in 2015. The Lancet. Neurology. 15: 13-5. PMID 26700899 DOI: 10.1016/S1474-4422(15)00339-7  0.474
2015 Kumar RG, Rubin JE, Berger RP, Kochanek PM, Wagner AK. Principal Components Derived from CSF Inflammatory Profiles Predict Outcome in Survivors after Severe Traumatic Brain Injury. Brain, Behavior, and Immunity. PMID 26705843 DOI: 10.1016/J.Bbi.2015.12.008  0.347
2015 Shein SL, Ferguson NM, Kochanek PM, Bayir H, Clark RS, Fink EL, Tyler-Kabara EC, Wisniewski SR, Tian Y, Balasubramani GK, Bell MJ. Effectiveness of Pharmacological Therapies for Intracranial Hypertension in Children With Severe Traumatic Brain Injury-Results From an Automated Data Collection System Time-Synched to Drug Administration. Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. PMID 26673840 DOI: 10.1097/Pcc.0000000000000610  0.45
2015 Mondello S, Shear DA, Bramlett HM, Dixon CE, Schmid Maj KE, Dietrich WD, Wang KK, Hayes RL, Glushakova O, Catania M, Richieri S, Povlishock J, Tortella FC, Kochanek PM. Insight into Preclinical Models of Traumatic Brain Injury Using Circulating Brain Damage Biomarkers: Operation Brain Trauma Therapy. Journal of Neurotrauma. PMID 26671651 DOI: 10.1089/Neu.2015.4132  0.76
2015 Browning M, Shear DA, Bramlett HM, Dixon CE, Mondello S, Schmid Maj KE, Poloyac SM, Dietrich WD, Hayes RL, Wang KK, Povlishock J, Tortella FC, Kochanek PM. Levetiracetam Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy. Journal of Neurotrauma. PMID 26671550 DOI: 10.1089/Neu.2015.4131  0.715
2015 Kochanek PM, Bramlett HM, Shear DA, Dixon CE, Mondello S, Dietrich WD, Hayes RL, Wang KK, Poloyac SM, Empey P, Povlishock J, Mountney A, Browning M, Deng-Bryant Y, Yan HQ, et al. Synthesis of Findings, Current Investigations, and Future Directions: Operation Brain Trauma Therapy. Journal of Neurotrauma. PMID 26671284 DOI: 10.1089/Neu.2015.4133  0.728
2015 Dixon CE, Bramlett HM, Dietrich WD, Shear DA, Yan HQ, Deng-Bryant Y, Mondello S, Wang KK, Hayes RL, Empey P, Povlishock J, Tortella FC, Kochanek PM. Cyclosporine Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy. Journal of Neurotrauma. PMID 26671075 DOI: 10.1089/Neu.2015.4122  0.75
2015 Shear DA, Bramlett HM, Dixon CE, Dietrich WD, Deng-Bryant Y, Schmid Maj KE, Mondello S, Wang KK, Hayes RL, Povlishock J, Kochanek PM, Tortella FC. Nicotinamide Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy. Journal of Neurotrauma. PMID 26670792 DOI: 10.1089/Neu.2015.4115  0.743
2015 Bramlett HM, Dietrich WD, Dixon CE, Shear DA, Schmid Maj KE, Mondello S, Wang KK, Hayes RL, Povlishock J, Tortella FC, Kochanek PM. Erythropoietin Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy. Journal of Neurotrauma. PMID 26670694 DOI: 10.1089/Neu.2015.4116  0.75
2015 Kochanek PM, Bayır H. Hidden Perils of the "Wild Blue Yonder" after Traumatic Brain Injury. Journal of Neurotrauma. PMID 26625357 DOI: 10.1089/Neu.2015.4329  0.492
2015 Pang D, Wu Y, Cummings J, Hsue V, Di Caro V, Clark R, Kochanek P, Aneja R. 1000: NEURORADIOLOGIC AND HISTOPATHOLOGIC CORRELATES OF BRAIN INJURY IN A MURINE MODEL OF SEPSIS. Critical Care Medicine. 43: 251-252. PMID 26570661 DOI: 10.1097/01.Ccm.0000474831.40412.35  0.48
2015 Jha R, Molyneaux B, Jackson T, Wallisch J, Vagni V, Poloyac S, Dixon C, Kochanek P. 491: GLIBENCLAMIDE REDUCES DIFFUSE CEREBRAL EDEMA IN A COMBINED MODEL OF TRAUMATIC BRAIN INJURY AND SHOCK. Critical Care Medicine. 43: 124. PMID 26570152 DOI: 10.1097/01.Ccm.0000474319.38132.1B  0.463
2015 Meinert E, Bell M, Adelson P, Buttram S, Kochanek P, Balasubramani G, Wisniewski S. 17: EARLY NUTRITIONAL SUPPORT IS ASSOCIATED WITH FAVORABLE OUTCOME IN PEDIATRIC TRAUMATIC BRAIN INJURY. Critical Care Medicine. 43: 5. PMID 26569678 DOI: 10.1097/01.Ccm.0000473845.82219.9B  0.474
2015 Mountney A, Bramlett HM, Dixon CE, Mondello S, Dietrich WD, Wang KK, Caudle KL, Empey P, Poloyac SM, Hayes RL, Povlishock J, Tortella FC, Kochanek PM, Shear DA. Simvastatin Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy. Journal of Neurotrauma. PMID 26541177 DOI: 10.1089/Neu.2015.4130  0.764
2015 Kochanek PM, Bramlett HM, Dixon CE, Shear DA, Dietrich WD, Schmid K, Mondello S, Wang KK, Hayes RL, Povlishock J, Tortella St FC. Operation Brain Trauma Therapy: Approach to Modeling, Therapy Evaluation, Drug Selection, and Biomarker Assessments, for a Multi-Center Pre-Clinical Drug Screening Consortium for Acute Therapies in Severe Traumatic Brain Injury. Journal of Neurotrauma. PMID 26439468 DOI: 10.1089/Neu.2015.4113  0.728
2015 Fidan E, Lewis J, Kline AE, Garman RH, Alexander H, Cheng JP, Bondi CO, Clark R, Dezfulian C, Kochanek PM, Kagan VE, Bay?r H. Repetitive mild traumatic brain injury in the developing brain: effects on long-term functional outcome and neuropathology. Journal of Neurotrauma. PMID 26214116 DOI: 10.1089/Neu.2015.3958  0.436
2015 Kochanek PM, Bell MJ. Tackling the Challenges of Clinical Trials for Severe Traumatic Brain Injury in Children: Screening, Phenotyping, and Adapting. Critical Care Medicine. 43: 1544-6. PMID 26079237 DOI: 10.1097/Ccm.0000000000001041  0.434
2015 Au AK, Chen Y, Lina D, Smith CM, Manole MD, Baltagi SA, Chu CT, Aneja RK, Bay?r H, Kochanek PM, Clark RS. Ischemia-induced autophagy contributes to neurodegeneration in cerebellar Purkinje cells in the developing rat brain and in primary cortical neurons in vitro. Biochimica Et Biophysica Acta. PMID 26071643 DOI: 10.1016/J.Bbadis.2015.06.007  0.308
2015 Willyerd FA, Empey PE, Philbrick A, Ikonomovic MD, Puccio AM, Kochanek PM, Okonkwo DO, Clark RS. Expression of ATP-Binding Cassette Transporters B1 and C1 after Severe Traumatic Brain Injury in Humans. Journal of Neurotrauma. PMID 25891836 DOI: 10.1089/Neu.2015.3879  0.45
2015 Newell E, Shellington DK, Simon DW, Bell MJ, Kochanek PM, Feldman K, Bayir H, Aneja RK, Carcillo JA, Clark RS. Cerebrospinal Fluid Markers of Macrophage and Lymphocyte Activation After Traumatic Brain Injury in Children. Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 16: 549-57. PMID 25850867 DOI: 10.1097/Pcc.0000000000000400  0.479
2015 Kochanek PM, Jackson TC. It might be time to let cooler heads prevail after mild traumatic brain injury or concussion. Experimental Neurology. 267: 13-7. PMID 25732932 DOI: 10.1016/J.Expneurol.2015.02.019  0.48
2015 Kochanek PM, Jackson TC, Ferguson NM, Carlson SW, Simon DW, Brockman EC, Ji J, Bay?r H, Poloyac SM, Wagner AK, Kline AE, Empey PE, Clark RS, Jackson EK, Dixon CE. Emerging therapies in traumatic brain injury. Seminars in Neurology. 35: 83-100. PMID 25714870 DOI: 10.1055/S-0035-1544237  0.477
2015 Chin KH, Bell MJ, Wisniewski SR, Balasubramani GK, Kochanek PM, Beers SR, Brown SD, Adelson PD. Effect of administration of neuromuscular blocking agents in children with severe traumatic brain injury on acute complication rates and outcomes: a secondary analysis from a randomized, controlled trial of therapeutic hypothermia. Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 16: 352-8. PMID 25599147 DOI: 10.1097/Pcc.0000000000000344  0.456
2015 Jackson TC, Du L, Janesko-Feldman K, Vagni VA, Dezfulian C, Poloyac SM, Jackson EK, Clark RS, Kochanek PM. The nuclear splicing factor RNA binding motif 5 promotes caspase activation in human neuronal cells, and increases after traumatic brain injury in mice. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 35: 655-66. PMID 25586139 DOI: 10.1038/Jcbfm.2014.242  0.395
2015 Kumar RG, Diamond ML, Boles JA, Berger RP, Tisherman SA, Kochanek PM, Wagner AK. Acute CSF interleukin-6 trajectories after TBI: associations with neuroinflammation, polytrauma, and outcome. Brain, Behavior, and Immunity. 45: 253-62. PMID 25555531 DOI: 10.1016/J.Bbi.2014.12.021  0.343
2015 Berger RP, Fromkin J, Rubin P, Snyder J, Richichi R, Kochanek P. Serum D-dimer concentrations are increased after pediatric traumatic brain injury. The Journal of Pediatrics. 166: 383-8. PMID 25454315 DOI: 10.1016/J.Jpeds.2014.10.036  0.387
2015 Ji J, Baart S, Vikulina AS, Clark RS, Anthonymuthu TS, Tyurin VA, Du L, St Croix CM, Tyurina YY, Lewis J, Skoda EM, Kline AE, Kochanek PM, Wipf P, Kagan VE, et al. Deciphering of mitochondrial cardiolipin oxidative signaling in cerebral ischemia-reperfusion. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 35: 319-28. PMID 25407268 DOI: 10.1038/Jcbfm.2014.204  0.361
2015 Wiley CA, Bonneh-Barkay D, Dixon CE, Lesniak A, Wang G, Bissel SJ, Kochanek PM. Role for mammalian chitinase 3-like protein 1 in traumatic brain injury. Neuropathology : Official Journal of the Japanese Society of Neuropathology. 35: 95-106. PMID 25377763 DOI: 10.1111/Neup.12158  0.456
2015 Santarsieri M, Kumar RG, Kochanek PM, Berga S, Wagner AK. Variable neuroendocrine-immune dysfunction in individuals with unfavorable outcome after severe traumatic brain injury. Brain, Behavior, and Immunity. 45: 15-27. PMID 25218898 DOI: 10.1016/J.Bbi.2014.09.003  0.356
2015 Fidan E, Foley L, New L, Kochanek P, Hitchens TK, Bayir H. 18: In Vivo Metabolic and Structural Imaging at 7t After Mild Traumatic Brain Injury in Immature Rats Critical Care Medicine. 43: 5. DOI: 10.1097/01.Ccm.0000473846.89843.A0  0.42
2015 Kim-Campbell N, Krehel N, Drabek T, Gladwin M, Callaway C, Dezfulian C, Bayir H, Kochanek P. 9: Renal Injury Associated With Free Hemoglobin In Rat Cardiopulmonary Bypass Is Attenuated By Nitrite. Critical Care Medicine. 43: 3. DOI: 10.1097/01.Ccm.0000473837.77933.31  0.356
2014 Gao W, Lu C, Kochanek PM, Berger RP. Serum amyloid A is increased in children with abusive head trauma: a gel-based proteomic analysis. Pediatric Research. 76: 280-6. PMID 24941216 DOI: 10.1038/Pr.2014.86  0.394
2014 Tress EE, Clark RS, Foley LM, Alexander H, Hickey RW, Drabek T, Kochanek PM, Manole MD. Blood brain barrier is impermeable to solutes and permeable to water after experimental pediatric cardiac arrest. Neuroscience Letters. 578: 17-21. PMID 24937271 DOI: 10.1016/J.Neulet.2014.06.020  0.346
2014 Shein SL, Shellington DK, Exo JL, Jackson TC, Wisniewski SR, Jackson EK, Vagni VA, Bay?r H, Clark RS, Dixon CE, Janesko-Feldman KL, Kochanek PM. Hemorrhagic shock shifts the serum cytokine profile from pro- to anti-inflammatory after experimental traumatic brain injury in mice. Journal of Neurotrauma. 31: 1386-95. PMID 24773520 DOI: 10.1089/Neu.2013.2985  0.378
2014 Diamond ML, Ritter AC, Failla MD, Boles JA, Conley YP, Kochanek PM, Wagner AK. IL-1β associations with posttraumatic epilepsy development: a genetics and biomarker cohort study. Epilepsia. 55: 1109-19. PMID 24754437 DOI: 10.1111/Epi.12628  0.309
2014 Walko TD, Bola RA, Hong JD, Au AK, Bell MJ, Kochanek PM, Clark RS, Aneja RK. Cerebrospinal fluid mitochondrial DNA: a novel DAMP in pediatric traumatic brain injury. Shock (Augusta, Ga.). 41: 499-503. PMID 24667615 DOI: 10.1097/Shk.0000000000000160  0.428
2014 Drabek T, Janata A, Wilson CD, Stezoski J, Janesko-Feldman K, Tisherman SA, Foley LM, Verrier JD, Kochanek PM. Minocycline attenuates brain tissue levels of TNF-α produced by neurons after prolonged hypothermic cardiac arrest in rats. Resuscitation. 85: 284-91. PMID 24513126 DOI: 10.1016/J.Resuscitation.2013.10.015  0.321
2014 Mtaweh H, Smith R, Kochanek PM, Wisniewski SR, Fabio A, Vavilala MS, Adelson PD, Toney NA, Bell MJ. Energy expenditure in children after severe traumatic brain injury. Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 15: 242-9. PMID 24394999 DOI: 10.1097/Pcc.0000000000000041  0.455
2014 Alexander SA, Ren D, Gunn SR, Kochanek PM, Tate J, Ikonomovic M, Conley YP. Interleukin 6 and apolipoprotein E as predictors of acute brain dysfunction and survival in critical care patients. American Journal of Critical Care : An Official Publication, American Association of Critical-Care Nurses. 23: 49-57. PMID 24382617 DOI: 10.4037/Ajcc2014578  0.31
2014 Manole MD, Kochanek PM, Bay?r H, Alexander H, Dezfulian C, Fink EL, Bell MJ, Clark RS. Brain tissue oxygen monitoring identifies cortical hypoxia and thalamic hyperoxia after experimental cardiac arrest in rats. Pediatric Research. 75: 295-301. PMID 24226633 DOI: 10.1038/Pr.2013.220  0.329
2014 Fink EL, Berger RP, Clark RS, Watson RS, Angus DC, Richichi R, Panigrahy A, Callaway CW, Bell MJ, Kochanek PM. Serum biomarkers of brain injury to classify outcome after pediatric cardiac arrest*. Critical Care Medicine. 42: 664-74. PMID 24164954 DOI: 10.1097/01.Ccm.0000435668.53188.80  0.456
2014 Hagos F, Ocque J, Nolin T, Poloyac S, Bayir H, Kochanek P, Clark R, Empey P. 627: Probenecid Increases N-Acetylcysteine Brain Levels Critical Care Medicine. 42. DOI: 10.1097/01.Ccm.0000458124.29933.D9  0.339
2014 Simon D, Aneja R, Lewis J, Alexander H, Bell M, Bayir H, Kochanek P, Clark R. 527: Minocycline Delays Recovery In A Model Of Pediatric Traumatic Brain Injury Critical Care Medicine. 42. DOI: 10.1097/01.Ccm.0000458024.61282.2C  0.491
2014 Anetakis K, Gedela S, Kochanek P, Sogawa Y, Fink E. 107: Combining Eeg And Serum Brain Biomarkers To Classify Mortality After Pediatric Cardiac Arrest Critical Care Medicine. 42. DOI: 10.1097/01.Ccm.0000457604.74401.60  0.344
2014 Uray T, Drabek T, Stezoski JP, Misse A, Janesko-Feldman K, Tisherman SA, Kochanek PM, Dezfulian C. Comparison of injury phenotype between ventricular fibrillation and asphyxial cardiac arrest in a rat model Resuscitation. 85. DOI: 10.1016/J.Resuscitation.2014.03.232  0.367
2013 Kochanek PM, Bell MJ. Making an IMPACT in traumatic brain injury research. The Lancet. Neurology. 12: 1132-3. PMID 24139679 DOI: 10.1016/S1474-4422(13)70245-X  0.467
2013 Jackson TC, Verrier JD, Drabek T, Janesko-Feldman K, Gillespie DG, Uray T, Dezfulian C, Clark RS, Bayir H, Jackson EK, Kochanek PM. Pharmacological inhibition of pleckstrin homology domain leucine-rich repeat protein phosphatase is neuroprotective: differential effects on astrocytes. The Journal of Pharmacology and Experimental Therapeutics. 347: 516-28. PMID 24023368 DOI: 10.1124/Jpet.113.206888  0.332
2013 Verrier JD, Jackson TC, Gillespie DG, Janesko-Feldman K, Bansal R, Goebbels S, Nave KA, Kochanek PM, Jackson EK. Role of CNPase in the oligodendrocytic extracellular 2',3'-cAMP-adenosine pathway. Glia. 61: 1595-606. PMID 23922219 DOI: 10.1002/Glia.22523  0.303
2013 Empey PE, de Mendizabal NV, Bell MJ, Bies RR, Anderson KB, Kochanek PM, Adelson PD, Poloyac SM. Therapeutic hypothermia decreases phenytoin elimination in children with traumatic brain injury. Critical Care Medicine. 41: 2379-87. PMID 23896831 DOI: 10.1097/Ccm.0B013E318292316C  0.447
2013 Cousar JL, Conley YP, Willyerd FA, Sarnaik AA, Puccio AM, Empey PE, Kochanek PM, Bell MJ, Okonkwo DO, Clark RS. Influence of ATP-binding cassette polymorphisms on neurological outcome after traumatic brain injury. Neurocritical Care. 19: 192-8. PMID 23896815 DOI: 10.1007/S12028-013-9881-7  0.433
2013 Bell MJ, Adelson PD, Hutchison JS, Kochanek PM, Tasker RC, Vavilala MS, Beers SR, Fabio A, Kelsey SF, Wisniewski SR. Differences in medical therapy goals for children with severe traumatic brain injury-an international study. Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 14: 811-8. PMID 23863819 DOI: 10.1097/Pcc.0B013E3182975E2F  0.455
2013 Brockman EC, Bay?r H, Blasiole B, Shein SL, Fink EL, Dixon C, Clark RS, Vagni VA, Ma L, Hsia CJ, Tisherman SA, Kochanek PM. Polynitroxylated-pegylated hemoglobin attenuates fluid requirements and brain edema in combined traumatic brain injury plus hemorrhagic shock in mice. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 33: 1457-64. PMID 23801241 DOI: 10.1038/Jcbfm.2013.104  0.342
2013 Kochanek PM, Berger RP, Fink EL, Au AK, Bay?r H, Bell MJ, Dixon CE, Clark RS. The potential for bio-mediators and biomarkers in pediatric traumatic brain injury and neurocritical care. Frontiers in Neurology. 4: 40. PMID 23637695 DOI: 10.3389/Fneur.2013.00040  0.493
2013 Bell MJ, Kochanek PM. Pediatric traumatic brain injury in 2012: the year with new guidelines and common data elements. Critical Care Clinics. 29: 223-38. PMID 23537673 DOI: 10.1016/J.Ccc.2012.11.004  0.449
2013 Kochanek PM, Dixon CE, Shellington DK, Shin SS, Bay?r H, Jackson EK, Kagan VE, Yan HQ, Swauger PV, Parks SA, Ritzel DV, Bauman R, Clark RS, Garman RH, Bandak F, et al. Screening of biochemical and molecular mechanisms of secondary injury and repair in the brain after experimental blast-induced traumatic brain injury in rats. Journal of Neurotrauma. 30: 920-37. PMID 23496248 DOI: 10.1089/Neu.2013.2862  0.442
2013 Abrahamson EE, Foley LM, Dekosky ST, Hitchens TK, Ho C, Kochanek PM, Ikonomovic MD. Cerebral blood flow changes after brain injury in human amyloid-beta knock-in mice. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 33: 826-33. PMID 23443172 DOI: 10.1038/Jcbfm.2013.24  0.426
2013 Thampatty BP, Klamerus MM, Oberly PJ, Feldman KL, Bell MJ, Tyler-Kabara EC, Adelson PD, Clark RS, Kochanek PM, Poloyac SM. Hypothermia decreases cerebrospinal fluid asymmetric dimethylarginine levels in children with traumatic brain injury. Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 14: 403-12. PMID 23439461 DOI: 10.1097/Pcc.0B013E31827212C0  0.486
2013 Jackson TC, Verrier JD, Kochanek PM. Anthraquinone-2-sulfonic acid (AQ2S) is a novel neurotherapeutic agent. Cell Death & Disease. 4: e451. PMID 23303125 DOI: 10.1038/Cddis.2012.187  0.37
2013 Blasiole B, Bayr H, Vagni VA, Janesko-Feldman K, Cheikhi A, Wisniewski SR, Long JB, Atkins J, Kagan V, Kochanek PM. Effect of hyperoxia on resuscitation of experimental combined traumatic brain injury and hemorrhagic shock in mice. Anesthesiology. 118: 649-63. PMID 23299361 DOI: 10.1097/Aln.0B013E318280A42D  0.46
2013 Adelson PD, Fellows-Mayle W, Kochanek PM, Dixon CE. Morris water maze function and histologic characterization of two age-at-injury experimental models of controlled cortical impact in the immature rat. Child's Nervous System : Chns : Official Journal of the International Society For Pediatric Neurosurgery. 29: 43-53. PMID 23089934 DOI: 10.1007/S00381-012-1932-4  0.48
2013 Foley LM, Iqbal O'Meara AM, Wisniewski SR, Hitchens TK, Melick JA, Ho C, Jenkins LW, Kochanek PM. MRI assessment of cerebral blood flow after experimental traumatic brain injury combined with hemorrhagic shock in mice. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 33: 129-36. PMID 23072750 DOI: 10.1038/Jcbfm.2012.145  0.48
2013 Fink EL, Panigrahy A, Clark RS, Fitz CR, Landsittel D, Kochanek PM, Zuccoli G. Regional brain injury on conventional and diffusion weighted MRI is associated with outcome after pediatric cardiac arrest. Neurocritical Care. 19: 31-40. PMID 22535278 DOI: 10.1007/S12028-012-9706-0  0.446
2013 Fink E, Tasker R, Beca J, Bell M, Clark R, Hutchison J, Vavilala M, Watson R, Weissfeld L, Kochanek P, Angus D, Investigators P. Prevalence of acute critical neurological disease in children: a global epidemiological assessment (PANGEA) Critical Care. 17: 346. DOI: 10.1186/Cc12284  0.357
2013 Mtaweh H, Toney N, Kochanek P, Bell M. 464: Nutrition Titrated To Energy Expenditure In Children With Traumatic Brain Injury-A Feasibility Study Critical Care Medicine. 41. DOI: 10.1097/01.Ccm.0000439608.71143.59  0.446
2013 Ferguson NM, Shein S, Kochanek P, Clark R, Tyler-Kabara E, Bell M. 448: Defining The Onset Of Intracranial Hypertension After Severe Traumatic Brain Injury In Children Critical Care Medicine. 41. DOI: 10.1097/01.Ccm.0000439592.87352.A4  0.484
2013 Simon D, Aneja R, Lewis J, Bayir H, Bell M, Kochanek P, Clark R. 10: Hmgb1 Translocation And Microglial Activation After Pediatric Tbi Attenuated By Minocycline Critical Care Medicine. 41. DOI: 10.1097/01.Ccm.0000439195.54340.48  0.444
2013 Dezfulian C, Misse A, Stezoski JP, Kochanek PM, Bayir H, Clark RS. P65: Nitrite after cardiac arrest has antioxidant effects reducing reperfusion cerebral hyperemia and subsequent caspase activation Nitric Oxide. 31. DOI: 10.1016/J.Niox.2013.02.067  0.352
2013 Uray T, Drabek T, Stezoski JP, Janesko-Feldman K, Tisherman SA, Kochanek PM, Dezfulian C. P35: Nitrite as a novel resuscitation adjunct after ventricular fibrillation cardiac arrest in rats: A preliminary report Nitric Oxide. 31. DOI: 10.1016/J.Niox.2013.02.037  0.313
2012 Alam HB, Pusateri AE, Kindzelski A, Egan D, Hoots K, Andrews MT, Rhee P, Tisherman S, Mann K, Vostal J, Kochanek PM, Scalea T, Deal V, Sheppard F, Sopko G, et al. Hypothermia and hemostasis in severe trauma: A new crossroads workshop report. The Journal of Trauma and Acute Care Surgery. 73: 809-17. PMID 23026915 DOI: 10.1097/Ta.0B013E318265D1B8  0.372
2012 Stippler M, Ortiz V, Adelson PD, Chang YF, Tyler-Kabara EC, Wisniewski SR, Fink EL, Kochanek PM, Brown SD, Bell MJ. Brain tissue oxygen monitoring after severe traumatic brain injury in children: relationship to outcome and association with other clinical parameters. Journal of Neurosurgery. Pediatrics. 10: 383-91. PMID 22978637 DOI: 10.3171/2012.8.Peds12165  0.482
2012 Topjian AA, Berg RA, Bierens JJ, Branche CM, Clark RS, Friberg H, Hoedemaekers CW, Holzer M, Katz LM, Knape JT, Kochanek PM, Nadkarni V, van der Hoeven JG, Warner DS. Brain resuscitation in the drowning victim. Neurocritical Care. 17: 441-67. PMID 22956050 DOI: 10.1007/S12028-012-9747-4  0.427
2012 Ji J, Kline AE, Amoscato A, Samhan-Arias AK, Sparvero LJ, Tyurin VA, Tyurina YY, Fink B, Manole MD, Puccio AM, Okonkwo DO, Cheng JP, Alexander H, Clark RS, Kochanek PM, et al. Lipidomics identifies cardiolipin oxidation as a mitochondrial target for redox therapy of brain injury. Nature Neuroscience. 15: 1407-13. PMID 22922784 DOI: 10.1038/Nn.3195  0.434
2012 Su E, Bell MJ, Kochanek PM, Wisniewski SR, Bayir H, Clark RS, Adelson PD, Tyler-Kabara EC, Janesko-Feldman KL, Berger RP. Increased CSF concentrations of myelin basic protein after TBI in infants and children: absence of significant effect of therapeutic hypothermia. Neurocritical Care. 17: 401-7. PMID 22890910 DOI: 10.1007/S12028-012-9767-0  0.395
2012 Hemerka JN, Wu X, Dixon CE, Garman RH, Exo JL, Shellington DK, Blasiole B, Vagni VA, Janesko-Feldman K, Xu M, Wisniewski SR, Bay?r H, Jenkins LW, Clark RS, Tisherman SA, ... Kochanek PM, et al. Severe brief pressure-controlled hemorrhagic shock after traumatic brain injury exacerbates functional deficits and long-term neuropathological damage in mice. Journal of Neurotrauma. 29: 2192-208. PMID 22738159 DOI: 10.1089/Neu.2011.2303  0.349
2012 Sparvero LJ, Amoscato AA, Dixon CE, Long JB, Kochanek PM, Pitt BR, Bayir H, Kagan VE. Mapping of phospholipids by MALDI imaging (MALDI-MSI): realities and expectations. Chemistry and Physics of Lipids. 165: 545-62. PMID 22692104 DOI: 10.1016/J.Chemphyslip.2012.06.001  0.311
2012 Au AK, Aneja RK, Bell MJ, Bayir H, Feldman K, Adelson PD, Fink EL, Kochanek PM, Clark RS. Cerebrospinal fluid levels of high-mobility group box 1 and cytochrome C predict outcome after pediatric traumatic brain injury. Journal of Neurotrauma. 29: 2013-21. PMID 22540160 DOI: 10.1089/Neu.2011.2171  0.385
2012 Shoykhet M, Simons DJ, Alexander H, Hosler C, Kochanek PM, Clark RS. Thalamocortical dysfunction and thalamic injury after asphyxial cardiac arrest in developing rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 4972-81. PMID 22492052 DOI: 10.1523/Jneurosci.5597-11.2012  0.396
2012 Verrier JD, Jackson TC, Bansal R, Kochanek PM, Puccio AM, Okonkwo DO, Jackson EK. The brain in vivo expresses the 2',3'-cAMP-adenosine pathway. Journal of Neurochemistry. 122: 115-25. PMID 22360621 DOI: 10.1111/J.1471-4159.2012.07705.X  0.405
2012 Kochanek PM, Carney N, Adelson PD, Ashwal S, Bell MJ, Bratton S, Carson S, Chesnut RM, Ghajar J, Goldstein B, Grant GA, Kissoon N, Peterson K, Selden NR, Tasker RC, et al. Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents--second edition. Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 13: S1-82. PMID 22217782 DOI: 10.1097/Pcc.0B013E31823F435C  0.404
2012 Manole MD, Kochanek PM, Foley LM, Hitchens TK, Bay?r H, Alexander H, Garman R, Ma L, Hsia CJ, Ho C, Clark RS. Polynitroxyl albumin and albumin therapy after pediatric asphyxial cardiac arrest: effects on cerebral blood flow and neurologic outcome. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 32: 560-9. PMID 22126915 DOI: 10.1038/Jcbfm.2011.165  0.328
2012 Salonia R, Bell MJ, Kochanek PM, Berger RP. The utility of near infrared spectroscopy in detecting intracranial hemorrhage in children. Journal of Neurotrauma. 29: 1047-53. PMID 22098538 DOI: 10.1089/Neu.2011.1890  0.321
2012 Ji J, Tyurina YY, Tang M, Feng W, Stolz DB, Clark RS, Meaney DF, Kochanek PM, Kagan VE, Bay?r H. Mitochondrial injury after mechanical stretch of cortical neurons in vitro: biomarkers of apoptosis and selective peroxidation of anionic phospholipids. Journal of Neurotrauma. 29: 776-88. PMID 21895519 DOI: 10.1089/Neu.2010.1602  0.341
2012 Smith RL, Lin JC, Adelson PD, Kochanek PM, Fink EL, Wisniewski SR, Bayir H, Tyler-Kabara EC, Clark RS, Brown SD, Bell MJ. Relationship between hyperglycemia and outcome in children with severe traumatic brain injury. Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 13: 85-91. PMID 21499170 DOI: 10.1097/Pcc.0B013E3182192C30  0.465
2012 Kochanek PM, Carney N, Adelson PD, Ashwal S, Bell MJ, Bratton S, Carson S, Chesnut RM, Ghajar J, Goldstein B, Grant GA, Kissoon N, Peterson K, Selden NR, Tasker RC, et al. Comments about the revised guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents Pediatric Critical Care Medicine. 13: 496-497. DOI: 10.1097/Pcc.0B013E318259Ee85  0.405
2012 Brockman E, Dixon C, Bayir H, Blasiole B, Clark R, Vagni V, Ma L, Hsia C, Kochanek P. 531: Polynitroxylated Pegylated Hemoglobin Attenuates Fluid Requirements And Brain Edema In Combined Traumatic Brain Injury Plus Hemorrhagic Shock In Mice Critical Care Medicine. 40: 1-328. DOI: 10.1097/01.Ccm.0000424749.78837.0B  0.47
2012 Ferguson NM, Shein S, Kochanek P, Clark R, Tyler-Kabara E, Bell M. 382: Understanding The Burden Of Intracranial Hypertension And Cerebral Hypoperfusion In Pediatric Traumatic Brain Injury (Tbi) – A Preliminary Analysis Critical Care Medicine. 40: 1-328. DOI: 10.1097/01.Ccm.0000424600.70801.3A  0.484
2012 Shein S, Feldman K, Vagni V, Xu M, Brockman E, Bayir H, Clark R, Kochanek P. 198: Delayed Hyperthermia Exacerbates Experimental Traumatic Brain Injury Critical Care Medicine. 40: 1-328. DOI: 10.1097/01.Ccm.0000424418.75053.57  0.486
2011 Manole MD, Tehranian-DePasquale R, Du L, Bayir H, Kochanek PM, Clark RS. Unmasking sex-based disparity in neuronal metabolism. Current Pharmaceutical Design. 17: 3854-60. PMID 21933143 DOI: 10.2174/138161211798357737  0.353
2011 Zhou J, Empey PE, Bies RR, Kochanek PM, Poloyac SM. Cardiac arrest and therapeutic hypothermia decrease isoform-specific cytochrome P450 drug metabolism. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 39: 2209-18. PMID 21868471 DOI: 10.1124/Dmd.111.040642  0.301
2011 Belikova NA, Glumac AL, Kapralova V, Cheikhi A, Tyurina YY, Vagni VA, Kochanek PM, Kagan VE, Bayir H. A high-throughput screening assay of ascorbate in brain samples. Journal of Neuroscience Methods. 201: 185-90. PMID 21855575 DOI: 10.1016/J.Jneumeth.2011.08.001  0.339
2011 Kochanek PM, Bramlett H, Dietrich WD, Dixon CE, Hayes RL, Povlishock J, Tortella FC, Wang KK. A novel multicenter preclinical drug screening and biomarker consortium for experimental traumatic brain injury: operation brain trauma therapy. The Journal of Trauma. 71: S15-24. PMID 21795873 DOI: 10.1097/Ta.0B013E31822117Fe  0.626
2011 Adelson PD, Srinivas R, Chang Y, Bell M, Kochanek PM. Cerebrovascular response in children following severe traumatic brain injury. Child's Nervous System : Chns : Official Journal of the International Society For Pediatric Neurosurgery. 27: 1465-76. PMID 21559825 DOI: 10.1007/S00381-011-1476-Z  0.479
2011 Garman RH, Jenkins LW, Switzer RC, Bauman RA, Tong LC, Swauger PV, Parks SA, Ritzel DV, Dixon CE, Clark RS, Bayir H, Kagan V, Jackson EK, Kochanek PM. Blast exposure in rats with body shielding is characterized primarily by diffuse axonal injury. Journal of Neurotrauma. 28: 947-59. PMID 21449683 DOI: 10.1089/Neu.2010.1540  0.395
2011 Wagner AK, Amin KB, Niyonkuru C, Postal BA, McCullough EH, Ozawa H, Dixon CE, Bayir H, Clark RS, Kochanek PM, Fabio A. CSF Bcl-2 and cytochrome C temporal profiles in outcome prediction for adults with severe TBI. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 31: 1886-96. PMID 21448217 DOI: 10.1038/Jcbfm.2011.31  0.39
2011 Shellington DK, Du L, Wu X, Exo J, Vagni V, Ma L, Janesko-Feldman K, Clark RS, Bayir H, Dixon CE, Jenkins LW, Hsia CJ, Kochanek PM. Polynitroxylated pegylated hemoglobin: a novel neuroprotective hemoglobin for acute volume-limited fluid resuscitation after combined traumatic brain injury and hemorrhagic hypotension in mice. Critical Care Medicine. 39: 494-505. PMID 21169820 DOI: 10.1097/Ccm.0B013E318206B1Fa  0.471
2011 Smith CM, Chen Y, Sullivan ML, Kochanek PM, Clark RS. Autophagy in acute brain injury: feast, famine, or folly? Neurobiology of Disease. 43: 52-9. PMID 20883784 DOI: 10.1016/J.Nbd.2010.09.014  0.449
2011 Smith CM, Adelson PD, Chang YF, Brown SD, Kochanek PM, Clark RS, Bayir H, Hinchberger J, Bell MJ. Brain-systemic temperature gradient is temperature-dependent in children with severe traumatic brain injury. Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 12: 449-54. PMID 20711083 DOI: 10.1097/Pcc.0B013E3181F390Dd  0.386
2011 Exo J, Kochanek PM, Adelson PD, Greene S, Clark RS, Bayir H, Wisniewski SR, Bell MJ. Intracranial pressure-monitoring systems in children with traumatic brain injury: combining therapeutic and diagnostic tools. Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 12: 560-5. PMID 20625341 DOI: 10.1097/Pcc.0B013E3181E8B3Ee  0.454
2011 Drabek T, Kochanek PM, Stezoski J, Wu X, Bayir H, Morhard RC, Stezoski SW, Tisherman SA. Intravenous hydrogen sulfide does not induce hypothermia or improve survival from hemorrhagic shock in pigs. Shock (Augusta, Ga.). 35: 67-73. PMID 20523266 DOI: 10.1097/Shk.0B013E3181E86F49  0.33
2010 Kochanek PM, Bell MJ, Bay?r H. Quo vadis 2010? - carpe diem: challenges and opportunities in pediatric traumatic brain injury. Developmental Neuroscience. 32: 335-42. PMID 21252553 DOI: 10.1159/000323016  0.486
2010 Su E, Bell MJ, Wisniewski SR, Adelson PD, Janesko-Feldman KL, Salonia R, Clark RS, Kochanek PM, Kagan VE, Bay?r H. α-Synuclein levels are elevated in cerebrospinal fluid following traumatic brain injury in infants and children: the effect of therapeutic hypothermia. Developmental Neuroscience. 32: 385-95. PMID 21124000 DOI: 10.1159/000321342  0.4
2010 Sparvero LJ, Amoscato AA, Kochanek PM, Pitt BR, Kagan VE, Bayir H. Mass-spectrometry based oxidative lipidomics and lipid imaging: applications in traumatic brain injury. Journal of Neurochemistry. 115: 1322-36. PMID 20950335 DOI: 10.1111/J.1471-4159.2010.07055.X  0.34
2010 Mehta A, Kochanek PM, Tyler-Kabara E, Adelson PD, Wisniewski SR, Berger RP, Sidoni MD, Bell RL, Clark RS, Bell MJ. Relationship of intracranial pressure and cerebral perfusion pressure with outcome in young children after severe traumatic brain injury. Developmental Neuroscience. 32: 413-9. PMID 20847542 DOI: 10.1159/000316804  0.408
2010 Berger RP, Bazaco MC, Wagner AK, Kochanek PM, Fabio A. Trajectory analysis of serum biomarker concentrations facilitates outcome prediction after pediatric traumatic and hypoxemic brain injury. Developmental Neuroscience. 32: 396-405. PMID 20847541 DOI: 10.1159/000316803  0.381
2010 Salonia R, Empey PE, Poloyac SM, Wisniewski SR, Klamerus M, Ozawa H, Wagner AK, Ruppel R, Bell MJ, Feldman K, Adelson PD, Clark RS, Kochanek PM. Endothelin-1 is increased in cerebrospinal fluid and associated with unfavorable outcomes in children after severe traumatic brain injury. Journal of Neurotrauma. 27: 1819-25. PMID 20684675 DOI: 10.1089/Neu.2010.1402  0.432
2010 Kochanek PM, Bayir H. Titrating oxygen during and after cardiopulmonary resuscitation. Jama. 303: 2190-1. PMID 20516423 DOI: 10.1001/Jama.2010.715  0.359
2010 Fink EL, Kochanek PM, Clark RS, Bell MJ. How I cool children in neurocritical care. Neurocritical Care. 12: 414-20. PMID 20146026 DOI: 10.1007/S12028-010-9334-5  0.471
2010 Haselkorn ML, Shellington DK, Jackson EK, Vagni VA, Janesko-Feldman K, Dubey RK, Gillespie DG, Cheng D, Bell MJ, Jenkins LW, Homanics GE, Schnermann J, Kochanek PM. Adenosine A1 receptor activation as a brake on the microglial response after experimental traumatic brain injury in mice. Journal of Neurotrauma. 27: 901-10. PMID 20121416 DOI: 10.1089/Neu.2009.1075  0.385
2010 Sarnaik AA, Conley YP, Okonkwo DO, Barr TL, Fink EL, Szabo C, Kochanek PM, Clark RS. Influence of PARP-1 polymorphisms in patients after traumatic brain injury. Journal of Neurotrauma. 27: 465-71. PMID 19925161 DOI: 10.1089/Neu.2009.1171  0.369
2010 Au AK, Bayir H, Kochanek PM, Clark RS. Evaluation of autophagy using mouse models of brain injury. Biochimica Et Biophysica Acta. 1802: 918-23. PMID 19879944 DOI: 10.1016/J.Bbadis.2009.10.010  0.467
2010 Tang M, Alexander H, Clark RS, Kochanek PM, Kagan VE, Bayir H. Minocycline reduces neuronal death and attenuates microglial response after pediatric asphyxial cardiac arrest. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 30: 119-29. PMID 19756023 DOI: 10.1038/Jcbfm.2009.194  0.34
2009 Manole MD, Kochanek PM, Fink EL, Clark RS. Postcardiac arrest syndrome: focus on the brain. Current Opinion in Pediatrics. 21: 745-50. PMID 19726989 DOI: 10.1097/Mop.0B013E328331E873  0.302
2009 Exo JL, Shellington DK, Bayir H, Vagni VA, Janesco-Feldman K, Ma L, Hsia CJ, Clark RS, Jenkins LW, Dixon CE, Kochanek PM. Resuscitation of traumatic brain injury and hemorrhagic shock with polynitroxylated albumin, hextend, hypertonic saline, and lactated Ringer's: Effects on acute hemodynamics, survival, and neuronal death in mice. Journal of Neurotrauma. 26: 2403-8. PMID 19691424 DOI: 10.1089/Neu.2009.0980  0.404
2009 Drabek T, Tisherman SA, Beuke L, Stezoski J, Janesko-Feldman K, Lahoud-Rahme M, Kochanek PM. Deep hypothermia attenuates microglial proliferation independent of neuronal death after prolonged cardiac arrest in rats. Anesthesia & Analgesia. 109: 914-923. PMID 19690267 DOI: 10.1213/Ane.0B013E3181B0511E  0.319
2009 de Toledo JS, Adelson PD, Watson RS, Gaines B, Brown SD, Kochanek PM, Wisniewski SR, Fink E, Bayir H, Clark RS, Bell MJ. Relationship between increases in pancreatic enzymes and cerebral events in children after traumatic brain injury. Neurocritical Care. 11: 322-9. PMID 19669945 DOI: 10.1007/S12028-009-9265-1  0.447
2009 Foley LM, Hitchens TK, Ho C, Janesko-Feldman KL, Melick JA, Bayir H, Kochanek PM. Magnetic resonance imaging assessment of macrophage accumulation in mouse brain after experimental traumatic brain injury. Journal of Neurotrauma. 26: 1509-19. PMID 19663686 DOI: 10.1089/Neu.2008.0747  0.391
2009 Kochanek PM, Tasker RC. Pediatric neurointensive care: 2008 update for the Rogers' Textbook of Pediatric Intensive Care. Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 10: 517-23. PMID 19584637 DOI: 10.1097/Pcc.0B013E3181Ab88Cd  0.355
2009 Puccio AM, Hoffman LA, Bayir H, Zullo TG, Fischer M, Darby J, Alexander S, Dixon CE, Okonkwo DO, Kochanek PM. Effect of short periods of normobaric hyperoxia on local brain tissue oxygenation and cerebrospinal fluid oxidative stress markers in severe traumatic brain injury. Journal of Neurotrauma. 26: 1241-9. PMID 19505175 DOI: 10.1089/Neu.2008.0624  0.322
2009 Kochanek PM. Bakken Lecture: the brain, the heart, and therapeutic hypothermia. Cleveland Clinic Journal of Medicine. 76. PMID 19376990 DOI: 10.3949/Ccjm.76.S2.02  0.411
2009 Dietrich WD, Bullock MR, Kochanek PM. Hypothermic therapies targeting brain and spinal cord injury. Introduction. Journal of Neurotrauma. 26: 297-8. PMID 19292693 DOI: 10.1089/Neu.2009.9958  0.373
2009 Kochanek PM, Fink EL, Bell MJ, Bayir H, Clark RS. Therapeutic hypothermia: applications in pediatric cardiac arrest. Journal of Neurotrauma. 26: 421-7. PMID 19271968 DOI: 10.1089/Neu.2008.0587  0.323
2009 Kochanek PM, Drabek T, Tisherman SA. Therapeutic Hypothermia: The Safar Vision Journal of Neurotrauma. 26: 417-420. PMID 19271966 DOI: 10.1089/Neu.2008.0612  0.333
2009 Lahoud-Rahme MS, Stezoski J, Kochanek PM, Melick J, Tisherman SA, Drabek T. Blood-brain barrier integrity in a rat model of emergency preservation and resuscitation Resuscitation. 80: 484-488. PMID 19203824 DOI: 10.1016/J.Resuscitation.2009.01.007  0.385
2009 Bayir H, Adelson PD, Wisniewski SR, Shore P, Lai Y, Brown D, Janesko-Feldman KL, Kagan VE, Kochanek PM. Therapeutic hypothermia preserves antioxidant defenses after severe traumatic brain injury in infants and children. Critical Care Medicine. 37: 689-95. PMID 19114918 DOI: 10.1097/CCM.0b013e318194abf2  0.358
2009 Manole MD, Foley LM, Hitchens TK, Kochanek PM, Hickey RW, Bayir H, Alexander H, Ho C, Clark RS. Magnetic resonance imaging assessment of regional cerebral blood flow after asphyxial cardiac arrest in immature rats. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 29: 197-205. PMID 18827831 DOI: 10.1038/Jcbfm.2008.112  0.302
2009 Berger RP, Ta'asan S, Rand A, Lokshin A, Kochanek P. Multiplex assessment of serum biomarker concentrations in well-appearing children with inflicted traumatic brain injury. Pediatric Research. 65: 97-102. PMID 18787505 DOI: 10.1203/Pdr.0B013E31818C7E27  0.447
2009 Dennis AM, Haselkorn ML, Vagni VA, Garman RH, Janesko-Feldman K, Bayir H, Clark RS, Jenkins LW, Dixon CE, Kochanek PM. Hemorrhagic shock after experimental traumatic brain injury in mice: effect on neuronal death. Journal of Neurotrauma. 26: 889-99. PMID 18781889 DOI: 10.1089/Neu.2008.0512  0.44
2009 Kochanek PM, Bauman RA, Long J, Dixon CE, Jenkins LW. Blast-induced traumatic brain injury and polytrauma--a critical problem begging for new insight and new therapies Journal of Neurotrauma. 110306202455053. DOI: 10.1089/Neu.2009-0893  0.448
2008 Bell MJ, Kochanek PM. Traumatic brain injury in children: recent advances in management. Indian Journal of Pediatrics. 75: 1159-1165. PMID 19132318 DOI: 10.1007/S12098-008-0240-1  0.506
2008 Kochanek PM, Bell MJ, Adelson PD. Hypothermia therapy after traumatic brain injury in children. The New England Journal of Medicine. 359: 1179; author reply 1. PMID 18788093  0.367
2008 Ahmad M, Rose ME, Vagni V, Griffith RP, Dixon CE, Kochanek PM, Hickey RW, Graham SH. Genetic disruption of cyclooxygenase-2 does not improve histological or behavioral outcome after traumatic brain injury in mice. Journal of Neuroscience Research. 86: 3605-12. PMID 18711748 DOI: 10.1002/Jnr.21809  0.416
2008 Han F, Drabek T, Stezoski J, Janesko-Feldman K, Stezoski SW, Clark RS, Bayir H, Tisherman SA, Kochanek PM. Protein nitration and poly-ADP-ribosylation in brain after rapid exsanguination cardiac arrest in a rat model of emergency preservation and resuscitation. Resuscitation. 79: 301-10. PMID 18640761 DOI: 10.1016/J.Resuscitation.2008.06.004  0.393
2008 Tehranian R, Rose ME, Vagni V, Pickrell AM, Griffith RP, Liu H, Clark RS, Dixon CE, Kochanek PM, Graham SH. Disruption of Bax protein prevents neuronal cell death but produces cognitive impairment in mice following traumatic brain injury. Journal of Neurotrauma. 25: 755-67. PMID 18627254 DOI: 10.1089/Neu.2007.0441  0.393
2008 Hartman M, Watson RS, Linde-Zwirble W, Clermont G, Lave J, Weissfeld L, Kochanek P, Angus D. Pediatric traumatic brain injury is inconsistently regionalized in the United States Pediatrics. 122: e172-e180. PMID 18595962 DOI: 10.1542/Peds.2007-3399  0.494
2008 Fink EL, Lai Y, Zhang X, Janesko-Feldman K, Adelson PD, Szabó C, Berger RP, Sarnaik AA, Kochanek PM, Clark RS. Quantification of poly(ADP-ribose)-modified proteins in cerebrospinal fluid from infants and children after traumatic brain injury. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 28: 1523-9. PMID 18506195 DOI: 10.1038/Jcbfm.2008.52  0.421
2008 Kochanek PM, Berger RP, Bayir H, Wagner AK, Jenkins LW, Clark RS. Biomarkers of primary and evolving damage in traumatic and ischemic brain injury: diagnosis, prognosis, probing mechanisms, and therapeutic decision making. Current Opinion in Critical Care. 14: 135-41. PMID 18388674 DOI: 10.1097/Mcc.0B013E3282F57564  0.476
2008 Foley LM, Hitchens TK, Melick JA, Bayir H, Ho C, Kochanek PM. Effect of inducible nitric oxide synthase on cerebral blood flow after experimental traumatic brain injury in mice. Journal of Neurotrauma. 25: 299-310. PMID 18373480 DOI: 10.1089/Neu.2007.0471  0.456
2008 Drabek T, Han F, Garman RH, Stezoski J, Tisherman SA, Stezoski SW, Morhard RC, Kochanek PM. Assessment of the delta opioid agonist DADLE in a rat model of lethal hemorrhage treated by emergency preservation and resuscitation. Resuscitation. 77: 220-8. PMID 18207625 DOI: 10.1016/J.Resuscitation.2007.11.020  0.321
2008 Lai Y, Chen Y, Watkins SC, Nathaniel PD, Guo F, Kochanek PM, Jenkins LW, Szabó C, Clark RS. Identification of poly-ADP-ribosylated mitochondrial proteins after traumatic brain injury. Journal of Neurochemistry. 104: 1700-11. PMID 17996029 DOI: 10.1111/J.1471-4159.2007.05114.X  0.368
2008 Clark RS, Bayir H, Chu CT, Alber SM, Kochanek PM, Watkins SC. Autophagy is increased in mice after traumatic brain injury and is detectable in human brain after trauma and critical illness. Autophagy. 4: 88-90. PMID 17957135 DOI: 10.4161/Auto.5173  0.449
2008 Lai Y, Hickey RW, Chen Y, Bayir H, Sullivan ML, Chu CT, Kochanek PM, Dixon CE, Jenkins LW, Graham SH, Watkins SC, Clark RS. Autophagy is increased after traumatic brain injury in mice and is partially inhibited by the antioxidant gamma-glutamylcysteinyl ethyl ester. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 28: 540-50. PMID 17786151 DOI: 10.1038/Sj.Jcbfm.9600551  0.433
2008 Sachse KT, Jackson EK, Wisniewski SR, Gillespie DG, Puccio AM, Clark RS, Dixon CE, Kochanek PM. Increases in cerebrospinal fluid caffeine concentration are associated with favorable outcome after severe traumatic brain injury in humans. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 28: 395-401. PMID 17684518 DOI: 10.1038/Sj.Jcbfm.9600539  0.412
2007 Buttram SD, Wisniewski SR, Jackson EK, Adelson PD, Feldman K, Bayir H, Berger RP, Clark RS, Kochanek PM. Multiplex assessment of cytokine and chemokine levels in cerebrospinal fluid following severe pediatric traumatic brain injury: effects of moderate hypothermia. Journal of Neurotrauma. 24: 1707-17. PMID 18001201 DOI: 10.1089/Neu.2007.0349  0.377
2007 Janata A, Bayegan K, Weihs WMMV, Schratter A, Holzer M, Frossard M, Sipos WD, Springler GMMV, Schmidt PD, Sterz F, Losert UM, Laggner AN, Kochanek PM, Behringer W. Emergency preservation and resuscitation improve survival after 15 minutes of normovolemic cardiac arrest in pigs. Critical Care Medicine. 35: 2785-2791. PMID 17901836 DOI: 10.1097/01.Ccm.0000288103.86029.66  0.354
2007 Bayir H, Tyurin VA, Tyurina YY, Viner R, Ritov V, Amoscato AA, Zhao Q, Zhang XJ, Janesko-Feldman KL, Alexander H, Basova LV, Clark RS, Kochanek PM, Kagan VE. Selective early cardiolipin peroxidation after traumatic brain injury: an oxidative lipidomics analysis. Annals of Neurology. 62: 154-69. PMID 17685468 DOI: 10.1002/Ana.21168  0.432
2007 Drabek T, Stezoski J, Garman RH, Han F, Henchir J, Tisherman SA, Stezoski SW, Kochanek PM. Exsanguination cardiac arrest in rats treated by 60 min, but not 75 min, emergency preservation and delayed resuscitation is associated with intact outcome. Resuscitation. 75: 114-23. PMID 17481798 DOI: 10.1016/J.Resuscitation.2007.03.012  0.314
2007 Bayir H, Kagan VE, Clark RS, Janesko-Feldman K, Rafikov R, Huang Z, Zhang X, Vagni V, Billiar TR, Kochanek PM. Neuronal NOS-mediated nitration and inactivation of manganese superoxide dismutase in brain after experimental and human brain injury. Journal of Neurochemistry. 101: 168-81. PMID 17394464 DOI: 10.1111/J.1471-4159.2006.04353.X  0.423
2007 Shore PM, Berger RP, Varma S, Janesko KL, Wisniewski SR, Clark RS, Adelson PD, Thomas NJ, Lai YC, Bayir H, Kochanek PM. Cerebrospinal fluid biomarkers versus glasgow coma scale and glasgow outcome scale in pediatric traumatic brain injury: the role of young age and inflicted injury. Journal of Neurotrauma. 24: 75-86. PMID 17263671 DOI: 10.1089/Neu.2006.0062  0.471
2007 Gao WM, Chadha MS, Berger RP, Omenn GS, Allen DL, Pisano M, Adelson PD, Clark RS, Jenkins LW, Kochanek PM. A gel-based proteomic comparison of human cerebrospinal fluid between inflicted and non-inflicted pediatric traumatic brain injury. Journal of Neurotrauma. 24: 43-53. PMID 17263669 DOI: 10.1089/Neu.2006.0061  0.417
2007 Clark RS, Nathaniel PD, Zhang X, Dixon CE, Alber SM, Watkins SC, Melick JA, Kochanek PM, Graham SH. boc-Aspartyl(OMe)-fluoromethylketone attenuates mitochondrial release of cytochrome c and delays brain tissue loss after traumatic brain injury in rats. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 27: 316-26. PMID 16736044 DOI: 10.1038/Sj.Jcbfm.9600338  0.35
2007 Fink EL, Callaway CW, Tisherman SA, Kochanek PM. Hypothermia in traumatic brain injury Critical Care Medicine. 35: 1999-2000. DOI: 10.1097/01.Ccm.0000277067.67995.Ad  0.498
2007 Kochanek PM, Berger RP, Margulies SS, Jenkins LW. Inflicted childhood neurotrauma: New insight into the detection, pathobiology, prevention, and treatment of our youngest patients with traumatic brain injury Journal of Neurotrauma. 24: 1-4. DOI: 10.1089/Neu.2006.0209  0.46
2006 Zhang X, Alber S, Watkins SC, Kochanek PM, Marion DW, Graham SH, Clark RS. Proteolysis consistent with activation of caspase-7 after severe traumatic brain injury in humans. Journal of Neurotrauma. 23: 1583-90. PMID 17115905 DOI: 10.1089/Neu.2006.23.1583  0.422
2006 Berger RP, Kochanek PM. Urinary S100B concentrations are increased after brain injury in children: A preliminary study. Pediatric Critical Care Medicine. 7: 557-561. PMID 17006387 DOI: 10.1097/01.Pcc.0000244426.37793.23  0.424
2006 Bayir H, Kochanek PM, Kagan VE. Oxidative stress in immature brain after traumatic brain injury. Developmental Neuroscience. 28: 420-31. PMID 16943665 DOI: 10.1159/000094168  0.435
2006 Cousar JL, Lai Y, Marco CD, Bayir H, Adelson PD, Janesko-Feldman KL, Kochanek PM, Clark RS. Heme oxygenase 1 in cerebrospinal fluid from infants and children after severe traumatic brain injury. Developmental Neuroscience. 28: 342-7. PMID 16943657 DOI: 10.1159/000094160  0.426
2006 Lai Y, Stange C, Wisniewski SR, Adelson PD, Janesko-Feldman KL, Brown DS, Kochanek PM, Clark RS. Mitochondrial heat shock protein 60 is increased in cerebrospinal fluid following pediatric traumatic brain injury. Developmental Neuroscience. 28: 336-41. PMID 16943656 DOI: 10.1159/000094159  0.41
2006 Berger RP, Adelson PD, Richichi R, Kochanek PM. Serum biomarkers after traumatic and hypoxemic brain injuries: insight into the biochemical response of the pediatric brain to inflicted brain injury. Developmental Neuroscience. 28: 327-335. PMID 16943655 DOI: 10.1159/000094158  0.493
2006 Kochanek PM. Pediatric traumatic brain injury: quo vadis? Developmental Neuroscience. 28: 244-255. PMID 16943648 DOI: 10.1159/000094151  0.493
2006 Tehranian R, Rose ME, Vagni V, Griffith RP, Wu S, Maits S, Zhang X, Clark RS, Dixon CE, Kochanek PM, Bernard O, Graham SH. Transgenic mice that overexpress the anti-apoptotic Bcl-2 protein have improved histological outcome but unchanged behavioral outcome after traumatic brain injury. Brain Research. 1101: 126-35. PMID 16782076 DOI: 10.1016/J.Brainres.2006.05.049  0.381
2006 Shore PM, Hand LL, Roy L, Trivedi P, Kochanek PM, Adelson PD. Reliability and validity of the Pediatric Intensity Level of Therapy (PILOT) scale: a measure of the use of intracranial pressure-directed therapies. Critical Care Medicine. 34: 1981-7. PMID 16691131 DOI: 10.1097/01.Ccm.0000220765.22184.Ed  0.37
2006 Wu X, Drabek T, Kochanek PM, Henchir J, Stezoski SW, Stezoski J, Cochran K, Garman R, Tisherman SA. Induction of profound hypothermia for emergency preservation and resuscitation allows intact survival after cardiac arrest resulting from prolonged lethal hemorrhage and trauma in dogs. Circulation. 113: 1974-82. PMID 16618818 DOI: 10.1161/Circulationaha.105.587204  0.348
2006 Poloyac SM, Zhang Y, Bies RR, Kochanek PM, Graham SH. Protective effect of the 20-HETE inhibitor HET0016 on brain damage after temporary focal ischemia. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 26: 1551-61. PMID 16570075 DOI: 10.1038/Sj.Jcbfm.9600309  0.335
2006 Statler KD, Alexander H, Vagni V, Holubkov R, Dixon CE, Clark RS, Jenkins L, Kochanek PM. Isoflurane exerts neuroprotective actions at or near the time of severe traumatic brain injury. Brain Research. 1076: 216-24. PMID 16473332 DOI: 10.1016/J.Brainres.2005.12.106  0.438
2006 Berger RP, Dulani T, Adelson PD, Leventhal JM, Richichi R, Kochanek PM. Identification of Inflicted Traumatic Brain Injury in Well-Appearing Infants Using Serum and Cerebrospinal Markers: A Possible Screening Tool Pediatrics. 117: 325-332. PMID 16452350 DOI: 10.1542/Peds.2005-0711  0.36
2006 Statler KD, Alexander H, Vagni V, Dixon CE, Clark RS, Jenkins L, Kochanek PM. Comparison of seven anesthetic agents on outcome after experimental traumatic brain injury in adult, male rats. Journal of Neurotrauma. 23: 97-108. PMID 16430376 DOI: 10.1089/Neu.2006.23.97  0.498
2006 Gao WM, Chadha MS, Kline AE, Clark RS, Kochanek PM, Dixon CE, Jenkins LW. Immunohistochemical analysis of histone H3 acetylation and methylation--evidence for altered epigenetic signaling following traumatic brain injury in immature rats. Brain Research. 1070: 31-4. PMID 16406269 DOI: 10.1016/J.Brainres.2005.11.038  0.363
2006 Kochanek PM, Clark RS, Statler KD, Jenkins LW. Physiological assessment and control in studies evaluating central nervous system injury: should size matter? Anesthesia and Analgesia. 102: 72-4. PMID 16368806 DOI: 10.1213/01.Ane.0000181101.71587.8A  0.377
2006 Zhang X, Chen Y, Ikonomovic MD, Nathaniel PD, Kochanek PM, Marion DW, DeKosky ST, Jenkins LW, Clark RS. Increased phosphorylation of protein kinase B and related substrates after traumatic brain injury in humans and rats. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 26: 915-26. PMID 16234845 DOI: 10.1038/Sj.Jcbfm.9600238  0.385
2006 Kochanek PM, Vagni VA, Janesko KL, Washington CB, Crumrine PK, Garman RH, Jenkins LW, Clark RS, Homanics GE, Dixon CE, Schnermann J, Jackson EK. Adenosine A1 receptor knockout mice develop lethal status epilepticus after experimental traumatic brain injury. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 26: 565-75. PMID 16121125 DOI: 10.1038/Sj.Jcbfm.9600218  0.325
2006 Haselkorn ML, Dennis AM, Vagni V, Janesko-Feldman K, Clark RS, Jenkins LW, Dixon CE, Kochanek PM. Effect Of Hemorrhagic Shock On Neuronal Death After Experimental Traumatic Brain Injury In Mice.: 65 Critical Care Medicine. 34. DOI: 10.1097/00003246-200612002-00065  0.439
2006 Sarnaik AA, Kochanek PM, Clark RS, Conley YP, Henning ML. THE POTENTIAL INFLUENCE OF ATP BINDING CASSETTE SUBFAMILY B-1 POLYMORPHISMS IN TRAUMATIC BRAIN INJURY: A PRELIMINARY STUDY. Critical Care Medicine. 34: A11. DOI: 10.1097/00003246-200612002-00041  0.426
2006 Kochanek PM, Melick JA, Foley LM, Hitchens TK, Ho C. Magnetic Resonance Imaging Assessment Of Macrophage Accumulation In Mouse Brain After Experimental Traumatic Brain Injury: A Preliminary Report.: 24 Critical Care Medicine. 34. DOI: 10.1097/00003246-200612002-00024  0.426
2006 Smith CM, Chen Y, Marco CD, Alexander HA, Jenkins LW, Kochanek PM, Clark RS. Gender- And Cell Compartment-Dependent Polyadp-Ribosylation After Traumatic Brain Injury In Juvenile Rats.: 18 Critical Care Medicine. 34. DOI: 10.1097/00003246-200612002-00018  0.474
2006 Dennis AM, Melick JA, Jenkins LW, Clark RS, Kochanek PM, Foley LM, Hitchens TK, Ho C. Effect Of Hemorrhagic Shock On Cerebral Blood Flow In Experimental Traumatic Brain Injury: Magnetic Resonance Imaging Assessment.: 17 Critical Care Medicine. 34. DOI: 10.1097/00003246-200612002-00017  0.402
2005 Wu X, Kochanek PM, Cochran K, Nozari A, Henchir J, Stezoski SW, Wagner R, Wisniewski S, Tisherman SA. Mild hypothermia improves survival after prolonged, traumatic hemorrhagic shock in pigs. The Journal of Trauma. 59: 291-9; discussion 29. PMID 16294067 DOI: 10.1097/01.Ta.0000179445.76729.2C  0.322
2005 Kochanek PM. Pediatric traumatic brain injury: beyond the guidelines. Current Treatment Options in Neurology. 7: 441-450. PMID 16221367 DOI: 10.1007/S11940-005-0044-9  0.405
2005 Berger RP, Adelson PD, Pierce MC, Dulani T, Cassidy LD, Kochanek PM. Serum neuron-specific enolase, S100B, and myelin basic protein concentrations after inflicted and noninflicted traumatic brain injury in children. Journal of Neurosurgery. 103: 61-8. PMID 16122007 DOI: 10.3171/Ped.2005.103.1.0061  0.41
2005 Kochanek PM, Hendrich KS, Jackson EK, Wisniewski SR, Melick JA, Shore PM, Janesko KL, Zacharia L, Ho C. Characterization of the effects of adenosine receptor agonists on cerebral blood flow in uninjured and traumatically injured rat brain using continuous arterial spin-labeled magnetic resonance imaging. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 25: 1596-612. PMID 15931163 DOI: 10.1038/Sj.Jcbfm.9600154  0.422
2005 Satchell MA, Lai Y, Kochanek PM, Wisniewski SR, Fink EL, Siedberg NA, Berger RP, DeKosky ST, Adelson PD, Clark RS. Cytochrome c, a biomarker of apoptosis, is increased in cerebrospinal fluid from infants with inflicted brain injury from child abuse. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 25: 919-27. PMID 15744250 DOI: 10.1038/Sj.Jcbfm.9600088  0.389
2005 Bayir H, Kagan VE, Borisenko GG, Tyurina YY, Janesko KL, Vagni VA, Billiar TR, Williams DL, Kochanek PM. Enhanced oxidative stress in iNOS-deficient mice after traumatic brain injury: support for a neuroprotective role of iNOS. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 25: 673-84. PMID 15716856 DOI: 10.1038/Sj.Jcbfm.9600068  0.423
2005 Zhang X, Chen Y, Jenkins LW, Kochanek PM, Clark RS. Bench-to-bedside review: Apoptosis/programmed cell death triggered by traumatic brain injury. Critical Care (London, England). 9: 66-75. PMID 15693986 DOI: 10.1186/Cc2950  0.353
2005 Puccio AM, Walter KA, Bayir H, Kochanek PM, Hoffman LA, Kim Y. HUMAN CEREBROSPINAL OXIDATIVE STRESS MARKER RESPONSE FOLLOWING A NORMOBARIC HYPEROXIA TRIAL AFTER SEVERE TRAUMATIC BRAIN INJURY. Critical Care Medicine. 33: A102. DOI: 10.1097/00003246-200512002-00361  0.431
2005 Bayir H, Clark RS, Zhang XJ, Kagan VE, Feldman KL, Vagni V, Kochanek PM. Mechanisms Of Tyrosine Nitration Of Mnsod After Traumatic Brain Injury.: 61 Critical Care Medicine. 33. DOI: 10.1097/00003246-200512002-00061  0.397
2005 Fink E, Lai Y, Adelson PD, Kochanek PM, Janesko K, Clark RS, Szabo C. A Novel Method For Quantification Of Poly(Adpribose)-Modified Proteins Validated In Cerebrospinal Fluid From Infants And Children After Traumatic Brain Injury.: 29 Critical Care Medicine. 33. DOI: 10.1097/00003246-200512002-00029  0.432
2005 Buttram SD, Bayir H, Clark RS, Kochanek PM, Wisniewski SR, Adelson PD, Janesko-Feldman K, Jackson EK, Berger R. A COMPREHENSIVE ASSESSMENT OF THE CYTOKINE RESPONSE AFTER SEVERE PEDIATRIC TRAUMATIC BRAIN INJURY: EFFECTS OF MODERATE HYPOTHERMIA. Critical Care Medicine. 33: A3. DOI: 10.1097/00003246-200512002-00010  0.488
2005 Lai Y, Chen Y, Zhang X, Nathaniel PD, Guo F, Jenkins LW, Watkins SC, Kochanek PM, Szabo C, Clark RSB. Poly-ADP-ribosylation is a prevalent post-translational modification of mitochondrial proteins in the brain Journal of Cerebral Blood Flow and Metabolism. 25. DOI: 10.1038/Sj.Jcbfm.9591524.0447  0.307
2004 Nozari A, Safar P, Wu X, Stezoski WS, Henchir J, Kochanek P, Klain M, Radovsky A, Tisherman SA. Suspended animation can allow survival without brain damage after traumatic exsanguination cardiac arrest of 60 minutes in dogs. The Journal of Trauma. 57: 1266-75. PMID 15625460 DOI: 10.1097/01.Ta.0000124268.24159.8B  0.366
2004 Nozari A, Safar P, Stezoski SW, Wu X, Henchir J, Radovsky A, Hanson K, Klein E, Kochanek PM, Tisherman SA. Mild hypothermia during prolonged cardiopulmonary cerebral resuscitation increases conscious survival in dogs. Critical Care Medicine. 32: 2110-6. PMID 15483422 DOI: 10.1097/01.Ccm.0000142700.19377.Ae  0.331
2004 Berger RP, Heyes MP, Wisniewski SR, Adelson PD, Thomas N, Kochanek PM. Assessment of the macrophage marker quinolinic acid in cerebrospinal fluid after pediatric traumatic brain injury: insight into the timing and severity of injury in child abuse. Journal of Neurotrauma. 21: 1123-30. PMID 15453983 DOI: 10.1089/Neu.2004.21.1123  0.471
2004 Shore PM, Thomas NJ, Clark RS, Adelson PD, Wisniewski SR, Janesko KL, Bayir H, Jackson EK, Kochanek PM. Continuous versus intermittent cerebrospinal fluid drainage after severe traumatic brain injury in children: effect on biochemical markers. Journal of Neurotrauma. 21: 1113-22. PMID 15453982 DOI: 10.1089/Neu.2004.21.1113  0.416
2004 DeKosky ST, Abrahamson EE, Taffe KM, Dixon CE, Kochanek PM, Ikonomovic MD. Effects of post-injury hypothermia and nerve growth factor infusion on antioxidant enzyme activity in the rat: implications for clinical therapies. Journal of Neurochemistry. 90: 998-1004. PMID 15287906 DOI: 10.1111/J.1471-4159.2004.02575.X  0.422
2004 Berger RP, Kochanek PM, Pierce MC. Biochemical markers of brain injury: could they be used as diagnostic adjuncts in cases of inflicted traumatic brain injury? Child Abuse & Neglect. 28: 739-54. PMID 15261469 DOI: 10.1016/J.Chiabu.2004.01.007  0.449
2004 DeKosky ST, Taffe KM, Abrahamson EE, Dixon CE, Kochanek PM, Ikonomovic MD. Time course analysis of hippocampal nerve growth factor and antioxidant enzyme activity following lateral controlled cortical impact brain injury in the rat. Journal of Neurotrauma. 21: 491-500. PMID 15165358 DOI: 10.1089/089771504774129838  0.425
2004 Lai Y, Kochanek PM, Adelson PD, Janesko K, Ruppel RA, Clark RS. Induction of the stress response after inflicted and non-inflicted traumatic brain injury in infants and children. Journal of Neurotrauma. 21: 229-37. PMID 15115598 DOI: 10.1089/089771504322972022  0.397
2004 Shore PM, Jackson EK, Wisniewski SR, Clark RS, Adelson PD, Kochanek PM. Vascular endothelial growth factor is increased in cerebrospinal fluid after traumatic brain injury in infants and children. Neurosurgery. 54: 605-11; discussion 6. PMID 15028134 DOI: 10.1227/01.Neu.0000108642.88724.Db  0.416
2004 Wagner AK, Bayir H, Ren D, Puccio A, Zafonte RD, Kochanek PM. Relationships between cerebrospinal fluid markers of excitotoxicity, ischemia, and oxidative damage after severe TBI: the impact of gender, age, and hypothermia. Journal of Neurotrauma. 21: 125-36. PMID 15000754 DOI: 10.1089/089771504322778596  0.392
2004 Bayir H, Marion DW, Puccio AM, Wisniewski SR, Janesko KL, Clark RS, Kochanek PM. Marked gender effect on lipid peroxidation after severe traumatic brain injury in adult patients. Journal of Neurotrauma. 21: 1-8. PMID 14987460 DOI: 10.1089/089771504772695896  0.445
2004 Fink EL, Alexander H, Marco CD, Dixon CE, Kochanek PM, Jenkins LW, Lai Y, Donovan HA, Hickey RW, Clark RS. Experimental model of pediatric asphyxial cardiopulmonary arrest in rats. Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 5: 139-44. PMID 14987343 DOI: 10.1097/01.Pcc.0000112376.29903.8F  0.33
2004 Bayir H, Zhang X, Clark RS, Kagan VE, Janesko KL, Du L, Vagni V, Kochanek PM. Nitration And Inactivation Of Mnsod After Experimental Cns Injury: Studies In Experimental Traumatic Brain Injury And Neuronal Culture: 87 Critical Care Medicine. 32. DOI: 10.1097/00003246-200412001-00087  0.455
2004 Fink EL, Bayir H, Lai Y, Chen Y, Zhang X, Alexander H, Kochanek PM, Clark RS. γ-GLUTAMYLCYSTEINE ETHYL ESTER INCREASES BRAIN GLUTATHIONE AFTER ASPHYXIAL CARDIAC ARREST IN POST-NATAL DAY 17 RATS: 86 Critical Care Medicine. 32. DOI: 10.1097/00003246-200412001-00086  0.347
2004 Puccio AM, Fabio A, Fischer MR, Li D, Marion DW, Yonas H, Dixon CE, Wagner AK, Kochanek PM. THE INFLUENCE OF GENDER ON INTERSTITIAL GLUTAMATE AND LACTATE/PYRUVATE LEVELS IN HUMAN BRAIN AFTER SEVERE TRAUMATIC BRAIN INJURY Critical Care Medicine. 32: A20. DOI: 10.1097/00003246-200412001-00077  0.472
2004 Hartman ME, Watson RS, Kochanek PM, Angus DC, Linde-Zwirble WT. Factors That Predict Undertriage To Tertiary Care For Children With Severe Traumatic Brain Injury: 5 Critical Care Medicine. 32. DOI: 10.1097/00003246-200412001-00005  0.448
2003 Statler KD, Janesko KL, Melick JA, Clark RS, Jenkins LW, Kochanek PM. Hyperglycolysis is exacerbated after traumatic brain injury with fentanyl vs. isoflurane anesthesia in rats. Brain Research. 994: 37-43. PMID 14642446 DOI: 10.1016/J.Brainres.2003.09.042  0.38
2003 Dixon CE, Ma X, Kline AE, Yan HQ, Ferimer H, Kochanek PM, Wisniewski SR, Jenkins LW, Marion DW. Acute etomidate treatment reduces cognitive deficits and histopathology in rats with traumatic brain injury. Critical Care Medicine. 31: 2222-7. PMID 12973183 DOI: 10.1097/01.Ccm.0000080493.04978.73  0.46
2003 Varma S, Janesko KL, Wisniewski SR, Bayir H, Adelson PD, Thomas NJ, Kochanek PM. F2-isoprostane and neuron-specific enolase in cerebrospinal fluid after severe traumatic brain injury in infants and children. Journal of Neurotrauma. 20: 781-6. PMID 12965056 DOI: 10.1089/089771503767870005  0.398
2003 Bayir H, Kochanek PM, Clark RS. Traumatic brain injury in infants and children: mechanisms of secondary damage and treatment in the intensive care unit. Critical Care Clinics. 19: 529-49. PMID 12848319 DOI: 10.1016/S0749-0704(03)00014-9  0.385
2003 Adelson PD, Bratton SL, Carney NA, Chesnut RM, du Coudray HE, Goldstein B, Kochanek PM, Miller HC, Partington MP, Selden NR, Warden CR, Wright DW, et al. Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents. Chapter 19. The role of anti-seizure prophylaxis following severe pediatric traumatic brain injury. Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 4: S72-5. PMID 12847355  0.358
2003 Adelson PD, Bratton SL, Carney NA, Chesnut RM, du Coudray HE, Goldstein B, Kochanek PM, Miller HC, Partington MD, Selden NR, Warden CW, Wright DW, et al. Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents. Chapter 17. Critical pathway for the treatment of established intracranial hypertension in pediatric traumatic brain injury. Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 4: S65-7. PMID 12847353  0.363
2003 Adelson PD, Bratton SL, Carney NA, Chesnut RM, du Coudray HE, Goldstein B, Kochanek PM, Miller HC, Partington MD, Selden NR, Warden CR, Wright DW, et al. Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents. Chapter 16. The use of corticosteroids in the treatment of severe pediatric traumatic brain injury. Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 4: S60-4. PMID 12847352  0.364
2003 Adelson PD, Bratton SL, Carney NA, Chesnut RM, du Coudray HE, Goldstein B, Kochanek PM, Miller HC, Partington MD, Selden NR, Warden CR, Wright DW, et al. Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents. Chapter 14. The role of temperature control following severe pediatric traumatic brain injury. Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 4: S53-5. PMID 12847350  0.366
2003 Adelson PD, Bratton SL, Carney NA, Chesnut RM, du Coudray HE, Goldstein B, Kochanek PM, Miller HC, Partington MD, Selden NR, Warden CR, Wright DW, et al. Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents. Chapter 13. The use of barbiturates in the control of intracranial hypertension in severe pediatric traumatic brain injury. Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 4: S49-52. PMID 12847349  0.364
2003 Adelson PD, Bratton SL, Carney NA, Chesnut RM, du Coudray HE, Goldstein B, Kochanek PM, Miller HC, Partington MD, Selden NR, Warden CR, Wright DW, et al. Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents. Chapter 12. Use of hyperventilation in the acute management of severe pediatric traumatic brain injury. Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 4: S45-8. PMID 12847348  0.343
2003 Adelson PD, Bratton SL, Carney NA, Chesnut RM, du Coudray HE, Goldstein B, Kochanek PM, Miller HC, Partington MD, Selden NR, Warden CR, Wright DW, et al. Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents. Chapter 11. Use of hyperosmolar therapy in the management of severe pediatric traumatic brain injury. Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 4: S40-4. PMID 12847347  0.352
2003 Adelson PD, Bratton SL, Carney NA, Chesnut RM, du Coudray HE, Goldstein B, Kochanek PM, Miller HC, Partington MD, Selden NR, Warden CR, Wright DW, et al. Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents. Chapter 10. The role of cerebrospinal fluid drainage in the treatment of severe pediatric traumatic brain injury. Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 4: S38-9. PMID 12847346  0.365
2003 Adelson PD, Bratton SL, Carney NA, Chesnut RM, du Coudray HE, Goldstein B, Kochanek PM, Miller HC, Partington MD, Selden NR, Warden CR, Wright DW, et al. Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents. Chapter 9. Use of sedation and neuromuscular blockade in the treatment of severe pediatric traumatic brain injury. Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 4: S34-7. PMID 12847345  0.366
2003 Adelson PD, Bratton SL, Carney NA, Chesnut RM, du Coudray HE, Goldstein B, Kochanek PM, Miller HC, Partington MD, Selden NR, Warden CR, Wright DW, et al. Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents. Chapter 5. Indications for intracranial pressure monitoring in pediatric patients with severe traumatic brain injury. Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 4: S19-24. PMID 12847341  0.362
2003 Adelson PD, Bratton SL, Carney NA, Chesnut RM, du Coudray HE, Goldstein B, Kochanek PM, Miller HC, Partington MD, Selden NR, et al. Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents. Chapter 4. Resuscitation of blood pressure and oxygenation and prehospital brain-specific therapies for the severe pediatric traumatic brain injury patient. Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 4: S12-8. PMID 12847340  0.378
2003 Adelson PD, Bratton SL, Carney NA, Chesnut RM, du Coudray HE, Goldstein B, Kochanek PM, Miller HC, Partington MD, Selden NR, Warden CR, Wright DW, et al. Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents. Chapter 2: Trauma systems, pediatric trauma centers, and the neurosurgeon. Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 4: S5-8. PMID 12847338  0.302
2003 Adelson PD, Bratton SL, Carney NA, Chesnut RM, du Coudray HE, Goldstein B, Kochanek PM, Miller HC, Partington MD, Selden NR, Warden CR, Wright DW, et al. Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents. Chapter 1: Introduction. Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 4: S2-4. PMID 12847337 DOI: 10.1097/01.Ccm.0000066600.71233.01  0.405
2003 Carney NA, Chesnut R, Kochanek PM. Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents. Pediatric Critical Care Medicine. 4. PMID 12847336 DOI: 10.1097/01.Ccm.0000067635.95882.24  0.363
2003 Han YY, Carcillo JA, Ruppel RA, Adelson PD, Wisniewski SR, Bell MJ, Janesko KL, Marion DW, Kochanek PM. Cerebrospinal fluid procalcitonin and severe traumatic brain injury in children. Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 3: 39-44. PMID 12793921 DOI: 10.1097/00130478-200201000-00010  0.469
2003 Behringer W, Safar P, Wu X, Kentner R, Radovsky A, Kochanek PM, Dixon CE, Tisherman SA. Survival without brain damage after clinical death of 60-120 mins in dogs using suspended animation by profound hypothermia. Critical Care Medicine. 31: 1523-31. PMID 12771628 DOI: 10.1097/01.Ccm.0000063450.73967.40  0.321
2003 Zhang X, Graham SH, Kochanek PM, Marion DW, Nathaniel PD, Watkins SC, Clark RS. Caspase-8 expression and proteolysis in human brain after severe head injury. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 1367-9. PMID 12738800 DOI: 10.1096/Fj.02-1067Fje  0.366
2003 Satchell MA, Zhang X, Kochanek PM, Dixon CE, Jenkins LW, Melick J, Szabó C, Clark RS. A dual role for poly-ADP-ribosylation in spatial memory acquisition after traumatic brain injury in mice involving NAD+ depletion and ribosylation of 14-3-3gamma. Journal of Neurochemistry. 85: 697-708. PMID 12694396 DOI: 10.1046/J.1471-4159.2003.01707.X  0.388
2003 Statler KD, Alexander HL, Vagni VA, Nemoto EM, Tofovic SP, Dixon CE, Jenkins LW, Marion DW, Kochanek PM. Moderate hypothermia may be detrimental after traumatic brain injury in fentanyl-anesthetized rats Critical Care Medicine. 31: 1134-1139. PMID 12682484 DOI: 10.1097/01.Ccm.0000054864.43122.52  0.501
2003 Hickey RW, Kochanek PM, Ferimer H, Alexander HL, Garman RH, Graham SH. Induced hyperthermia exacerbates neurologic neuronal histologic damage after asphyxial cardiac arrest in rats. Critical Care Medicine. 31: 531-5. PMID 12576962 DOI: 10.1097/01.Ccm.0000050323.84293.11  0.374
2003 Seidberg NA, Clark RS, Zhang X, Lai Y, Chen M, Graham SH, Kochanek PM, Watkins SC, Marion DW. Alterations in inducible 72-kDa heat shock protein and the chaperone cofactor BAG-1 in human brain after head injury. Journal of Neurochemistry. 84: 514-21. PMID 12558971 DOI: 10.1046/J.1471-4159.2003.01547.X  0.422
2003 Bayir H, Clark RS, Kochanek PM. Promising strategies to minimize secondary brain injury after head trauma. Critical Care Medicine. 31: S112-7. PMID 12544985 DOI: 10.1097/00003246-200301001-00016  0.499
2003 Bayir H, Kochanek PM, Liu SX, Arroyo A, Osipov A, Jiang J, Wisniewski S, Adelson PD, Graham SH, Kagan VE. Increased S-nitrosothiols and S-nitrosoalbumin in cerebrospinal fluid after severe traumatic brain injury in infants and children: indirect association with intracranial pressure. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 23: 51-61. PMID 12500091 DOI: 10.1097/01.Wcb.0000040399.30600.E3  0.414
2003 Berger RP, Pierce MC, Wisniewski SR, Adelson PD, Kochanek PM. Serum S100B concentrations are increased after closed head injury in children: a preliminary study. Journal of Neurotrauma. 19: 1405-9. PMID 12490005 DOI: 10.1089/089771502320914633  0.425
2003 Carney NA, Chesnut R, Kochanek PM. Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents Journal of Trauma-Injury Infection and Critical Care. 54. DOI: 10.1097/00005373-200306001-00002  0.404
2003 Carney NA, Chesnut R, Kochanek PM. Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents Critical Care Medicine. 31. DOI: 10.1097/00003246-200306006-00001  0.404
2002 Ciallella JR, Ikonomovic MD, Paljug WR, Wilbur YI, Dixon CE, Kochanek PM, Marion DW, DeKosky ST. Changes in expression of amyloid precursor protein and interleukin-1beta after experimental traumatic brain injury in rats. Journal of Neurotrauma. 19: 1555-67. PMID 12542857 DOI: 10.1089/089771502762300229  0.436
2002 Marion DW, Puccio A, Wisniewski SR, Kochanek P, Dixon CE, Bullian L, Carlier P. Effect of hyperventilation on extracellular concentrations of glutamate, lactate, pyruvate, and local cerebral blood flow in patients with severe traumatic brain injury. Critical Care Medicine. 30: 2619-2625. PMID 12483048 DOI: 10.1097/00003246-200212000-00001  0.463
2002 Kochanek PM, Hendrich KS, Dixon CE, Schiding JK, Williams DS, Ho C. Cerebral blood flow at one year after controlled cortical impact in rats: assessment by magnetic resonance imaging. Journal of Neurotrauma. 19: 1029-37. PMID 12482116 DOI: 10.1089/089771502760341947  0.394
2002 Ruppel RA, Clark RS, Bayir H, Satchell MA, Kochanek PM. Critical mechanisms of secondary damage after inflicted head injury in infants and children. Neurosurgery Clinics of North America. 13: 169-82, v. PMID 12391702 DOI: 10.1016/S1042-3680(01)00005-5  0.407
2002 Jenkins LW, Peters GW, Dixon CE, Zhang X, Clark RS, Skinner JC, Marion DW, Adelson PD, Kochanek PM. Conventional and functional proteomics using large format two-dimensional gel electrophoresis 24 hours after controlled cortical impact in postnatal day 17 rats. Journal of Neurotrauma. 19: 715-40. PMID 12165133 DOI: 10.1089/08977150260139101  0.32
2002 Zhang X, Chen J, Graham SH, Du L, Kochanek PM, Draviam R, Guo F, Nathaniel PD, Szabó C, Watkins SC, Clark RS. Intranuclear localization of apoptosis-inducing factor (AIF) and large scale DNA fragmentation after traumatic brain injury in rats and in neuronal cultures exposed to peroxynitrite. Journal of Neurochemistry. 82: 181-91. PMID 12091479 DOI: 10.1046/J.1471-4159.2002.00975.X  0.404
2002 Rose ME, Huerbin MB, Melick J, Marion DW, Palmer AM, Schiding JK, Kochanek PM, Graham SH. Regulation of interstitial excitatory amino acid concentrations after cortical contusion injury. Brain Research. 935: 40-6. PMID 12062471 DOI: 10.1016/S0006-8993(02)02445-9  0.338
2002 Narayan RK, Michel ME, Ansell B, Baethmann A, Biegon A, Bracken MB, Bullock MR, Choi SC, Clifton GL, Contant CF, Coplin WM, Dietrich WD, Ghajar J, Grady SM, Grossman RG, ... ... Kochanek PM, et al. Clinical trials in head injury. Journal of Neurotrauma. 19: 503-57. PMID 12042091 DOI: 10.1089/089771502753754037  0.403
2002 Kline AE, Bolinger BD, Kochanek PM, Carlos TM, Yan HQ, Jenkins LW, Marion DW, Dixon CE. Acute systemic administration of interleukin-10 suppresses the beneficial effects of moderate hypothermia following traumatic brain injury in rats. Brain Research. 937: 22-31. PMID 12020858 DOI: 10.1016/S0006-8993(02)02458-7  0.413
2002 Bayir H, Kagan VE, Tyurina YY, Tyurin V, Ruppel RA, Adelson PD, Graham SH, Janesko K, Clark RS, Kochanek PM. Assessment of antioxidant reserves and oxidative stress in cerebrospinal fluid after severe traumatic brain injury in infants and children. Pediatric Research. 51: 571-8. PMID 11978879 DOI: 10.1203/00006450-200205000-00005  0.359
2002 Holzer M, Sterz F, Darby JM, Padosch SA, Kern KB, Böttiger BW, Polderman KH, Girbes ARJ, Bernard SA, Buist MD, Safar P, Kochanek PM. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest New England Journal of Medicine. 346: 549-556. PMID 11856793 DOI: 10.1056/Nejmoa012689  0.304
2002 Berger RP, Pierce MC, Wisniewski SR, Adelson PD, Clark RS, Ruppel RA, Kochanek PM. Neuron-specific enolase and S100B in cerebrospinal fluid after severe traumatic brain injury in infants and children. Pediatrics. 109: E31. PMID 11826241 DOI: 10.1542/Peds.109.2.E31  0.413
2002 Behringer W, Safar P, Kentner R, Wu X, Kagan VE, Radovsky A, Clark RS, Kochanek PM, Subramanian M, Tyurin VA, Tyurina YY, Tisherman SA. Antioxidant Tempol enhances hypothermic cerebral preservation during prolonged cardiac arrest in dogs. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 22: 105-17. PMID 11807400 DOI: 10.1097/00004647-200201000-00013  0.318
2002 Hartman ME, Watson RS, Kochanek PM, Angus DC. Is The Management Of Severe Tbi In Children In The Us Appropriately Regionalized?: 51 Critical Care Medicine. 30. DOI: 10.1097/00003246-200212001-00051  0.302
2002 Bayir H, Janesko KL, Kochanek PM. Therapeutic Hypothermia Attenuates Oxidative Stress After Traumatic Brain Injury In Infants And Children: 27 Critical Care Medicine. 30. DOI: 10.1097/00003246-200212001-00027  0.42
2002 Lai Y, Kochanek PM, Shore PM, Janesko K, Bayir H, Clark RS. Age-Related Increase In Protein Kinase B (Akt) After Pediatric Traumatic Brain Injury: 26 Critical Care Medicine. 30. DOI: 10.1097/00003246-200212001-00026  0.419
2001 Robertson CL, Bell MJ, Kochanek PM, Adelson PD, Ruppel RA, Carcillo JA, Wisniewski SR, Mi Z, Janesko KL, Clark RS, Marion DW, Graham SH, Jackson EK. Increased adenosine in cerebrospinal fluid after severe traumatic brain injury in infants and children: association with severity of injury and excitotoxicity. Critical Care Medicine. 29: 2287-93. PMID 11801827 DOI: 10.1097/00003246-200112000-00009  0.455
2001 Wu X, Prueckner S, Rollwagen F, Kentner R, Stezoski J, Kochanek PM, Behringer W, Pasculle WA, Safar P, Tisherman SA. Gut damage during hemorrhagic shock: effects on survival of oral or enteral interleukin-6. Shock. 16: 449-453. PMID 11770043 DOI: 10.1097/00024382-200116060-00008  0.301
2001 Statler KD, Jenkins LW, Dixon CE, Clark RS, Marion DW, Kochanek PM. The simple model versus the super model: translating experimental traumatic brain injury research to the bedside. Journal of Neurotrauma. 18: 1195-206. PMID 11721738 DOI: 10.1089/089771501317095232  0.433
2001 Adelson PD, Jenkins LW, Hamilton RL, Robichaud P, Tran MP, Kochanek PM. Histopathologic response of the immature rat to diffuse traumatic brain injury. Journal of Neurotrauma. 18: 967-76. PMID 11686497 DOI: 10.1089/08977150152693674  0.463
2001 Robertson CL, Minamino N, Ruppel RA, Kangawa K, Wisniewski SR, Tsuji T, Janesko KL, Ohta H, Adelson PD, Marion DW, Kochanek PM. Increased adrenomedullin in cerebrospinal fluid after traumatic brain injury in infants and children. Journal of Neurotrauma. 18: 861-8. PMID 11565598 DOI: 10.1089/089771501750451785  0.427
2001 Clark RSB, Chen M, Kochanek PM, Watkins SC, Jin KL, Draviam R, Nathaniel PD, Pinto R, Marion DW, Graham SH. Detection of single- and double-strand DNA breaks after traumatic brain injury in rats: comparison of in situ labeling techniques using DNA polymerase I, the Klenow fragment of DNA polymerase I, and terminal deoxynucleotidyl transferase. Journal of Neurotrauma. 18: 675-89. PMID 11497094 DOI: 10.1089/089771501750357627  0.325
2001 Kochanek PM, Clark RS, Ruppel RA, Dixon CE. Cerebral resuscitation after traumatic brain injury and cardiopulmonary arrest in infants and children in the new millennium. Pediatric Clinics of North America. 48: 661-81. PMID 11411299 DOI: 10.1016/S0031-3955(05)70333-3  0.465
2001 Kochanek PM, Hendrich KS, Robertson CL, Williams DS, Melick JA, Ho C, Marion DW, Jackson EK. Assessment of the effect of 2-chloroadenosine in normal rat brain using spin-labeled MRI measurement of perfusion. Magnetic Resonance in Medicine. 45: 924-9. PMID 11323821 DOI: 10.1002/Mrm.1123  0.365
2001 Bell MJ, Robertson CS, Kochanek PM, Goodman JC, Gopinath SP, Carcillo JA, Clark RS, Marion DW, Mi Z, Jackson EK. Interstitial brain adenosine and xanthine increase during jugular venous oxygen desaturations in humans after traumatic brain injury. Critical Care Medicine. 29: 399-404. PMID 11246323 DOI: 10.1097/00003246-200102000-00033  0.451
2001 Kochanek PM, Janesko KL, Jenkins LW, Yan HQ, Kibbe MR, Robichaud P, Wooditch AC, Clark RS, Dixon CE, Marion DW, Billiar TR. Adenovirus-mediated transfer and expression of beta-gal in injured hippocampus after traumatic brain injury in mice. Journal of Neurotrauma. 18: 73-82. PMID 11200251 DOI: 10.1089/089771501750055785  0.429
2001 Ruppel RA, Kochanek PM, Adelson PD, Rose ME, Wisniewski SR, Bell MJ, Clark RS, Marion DW, Graham SH. Excitatory amino acid concentrations in ventricular cerebrospinal fluid after severe traumatic brain injury in infants and children: the role of child abuse. The Journal of Pediatrics. 138: 18-25. PMID 11148507 DOI: 10.1067/Mpd.2001.110979  0.415
2000 Kochanek PM, Clark RS, Ruppel RA, Adelson PD, Bell MJ, Whalen MJ, Robertson CL, Satchell MA, Seidberg NA, Marion DW, Jenkins LW. Biochemical, cellular, and molecular mechanisms in the evolution of secondary damage after severe traumatic brain injury in infants and children: Lessons learned from the bedside. Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 1: 4-19. PMID 12813280 DOI: 10.1097/00130478-200007000-00003  0.441
2000 Whalen MJ, Clark RS, Dixon CE, Robichaud P, Marion DW, Vagni V, Graham S, Virag L, Hasko G, Stachlewitz R, Szabo C, Kochanek PM. Traumatic brain injury in mice deficient in poly-ADP(ribose) polymerase: a preliminary report. Acta Neurochirurgica. Supplement. 76: 61-4. PMID 11450092 DOI: 10.1007/978-3-7091-6346-7_12  0.394
2000 Robertson CL, Minamino N, Ruppel RA, Kangawa K, Adelson PD, Tsuji T, Wisniewski SR, Ohta H, Janesko KL, Kochanek PM. Increased adrenomedullin in cerebrospinal fluid after traumatic brain injury in children: a preliminary report. Acta Neurochirurgica. Supplement. 76: 419-21. PMID 11450058 DOI: 10.1097/00003246-199912001-00187  0.442
2000 Robertson CL, Hendrich KS, Kochanek PM, Jackson EK, Melick JA, Graham SH, Marion DW, Williams DS, Ho C. Assessment of 2-chloroadenosine treatment after experimental traumatic brain injury in the rat using arterial spin-labeled MRI: a preliminary report. Acta Neurochirurgica. Supplement. 76: 187-9. PMID 11450003 DOI: 10.1007/978-3-7091-6346-7_37  0.445
2000 Statler KD, Kochanek PM, Dixon CE, Alexander HL, Warner DS, Clark RS, Wisniewski SR, Graham SH, Jenkins LW, Marion DW, Safar PJ. Isoflurane improves long-term neurologic outcome versus fentanyl after traumatic brain injury in rats. Journal of Neurotrauma. 17: 1179-89. PMID 11186231 DOI: 10.1089/Neu.2000.17.1179  0.458
2000 Whalen MJ, Carlos TM, Wisniewski SR, Clark RS, Mellick JA, Marion DW, Kochanek PM. Effect of neutropenia and granulocyte colony stimulating factor-induced neutrophilia on blood-brain barrier permeability and brain edema after traumatic brain injury in rats. Critical Care Medicine. 28: 3710-7. PMID 11098978 DOI: 10.1097/00003246-200011000-00029  0.482
2000 Tyurin VA, Tyurina YY, Borisenko GG, Sokolova TV, Ritov VB, Quinn PJ, Rose M, Kochanek P, Graham SH, Kagan VE. Oxidative stress following traumatic brain injury in rats: Quantitation of biomarkers and detection of free radical intermediates Journal of Neurochemistry. 75: 2178-2189. PMID 11032908 DOI: 10.1046/J.1471-4159.2000.0752178.X  0.463
2000 Robertson CL, Clark RS, Dixon CE, Alexander HL, Graham SH, Wisniewski SR, Marion DW, Safar PJ, Kochanek PM. No long-term benefit from hypothermia after severe traumatic brain injury with secondary insult in rats. Critical Care Medicine. 28: 3218-23. PMID 11008985 DOI: 10.1097/00003246-200009000-00017  0.499
2000 Clark RS, Kochanek PM, Adelson PD, Bell MJ, Carcillo JA, Chen M, Wisniewski SR, Janesko K, Whalen MJ, Graham SH. Increases in bcl-2 protein in cerebrospinal fluid and evidence for programmed cell death in infants and children after severe traumatic brain injury. The Journal of Pediatrics. 137: 197-204. PMID 10931412 DOI: 10.1067/Mpd.2000.106903  0.43
2000 Hickey RW, Zhu RL, Alexander HL, Jin KL, Stetler RA, Chen J, Kochanek PM, Graham SH. 10 kD mitochondrial matrix heat shock protein mRNA is induced following global brain ischemia in the rat Molecular Brain Research. 79: 169-173. PMID 10925156 DOI: 10.1016/S0169-328X(00)00113-3  0.313
2000 Hickey RW, Kochanek PM, Ferimer H, Graham SH, Safar P. Hypothermia and hyperthermia in children after resuscitation from cardiac arrest. Pediatrics. 106: 118-22. PMID 10878160 DOI: 10.1542/Peds.106.1.118  0.426
2000 Whalen MJ, Carlos TM, Kochanek PM, Wisniewski SR, Bell MJ, Clark RS, DeKosky ST, Marion DW, Adelson PD. Interleukin-8 is increased in cerebrospinal fluid of children with severe head injury. Critical Care Medicine. 28: 929-34. PMID 10809261 DOI: 10.1097/00003246-200004000-00003  0.401
2000 Woods RJ, Prueckner S, Safar P, Takasu A, Tisherman SA, Jackson EK, Radovsky A, Kochanek P, Behringer W, Stezoski SW, Hans R. Adenosine by aortic flush fails to augment the brain preservation effect of mild hypothermia during exsanguination cardiac arrest in dogs - an exploratory study. Resuscitation. 44: 47-59. PMID 10699700 DOI: 10.1016/S0300-9572(99)00164-1  0.394
2000 Whalen MJ, Carlos TM, Dixon CE, Robichaud P, Clark RS, Marion DW, Kochanek PM. Reduced brain edema after traumatic brain injury in mice deficient in P-selectin and intercellular adhesion molecule-1. Journal of Leukocyte Biology. 67: 160-8. PMID 10670575 DOI: 10.1002/Jlb.67.2.160  0.429
2000 Clark RS, Kochanek PM, Watkins SC, Chen M, Dixon CE, Seidberg NA, Melick J, Loeffert JE, Nathaniel PD, Jin KL, Graham SH. Caspase-3 mediated neuronal death after traumatic brain injury in rats. Journal of Neurochemistry. 74: 740-53. PMID 10646526 DOI: 10.1046/J.1471-4159.2000.740740.X  0.396
2000 Ciallella JR, Flood DG, Ikonomovic MD, Paljug W, Dixon CE, Kochanek PM, Marion DW, DeKosky ST. Amyloid precursor protein and amyloid-β-production are altered by caspase inhibition after traumatic brain injury in humanized Aβ mice Neurobiology of Aging. 21: 18. DOI: 10.1016/S0197-4580(00)82757-8  0.372
1999 Hendrich KS, Kochanek PM, Williams DS, Schiding JK, Marion DW, Ho C. Early perfusion after controlled cortical impact in rats: quantification by arterial spin-labeled MRI and the influence of spin-lattice relaxation time heterogeneity. Magnetic Resonance in Medicine. 42: 673-681. PMID 10502755 DOI: 10.1002/(Sici)1522-2594(199910)42:4<673::Aid-Mrm8>3.0.Co;2-B  0.384
1999 Sinz EH, Kochanek PM, Dixon CE, Clark RS, Carcillo JA, Schiding JK, Chen M, Wisniewski SR, Carlos TM, Williams D, DeKosky ST, Watkins SC, Marion DW, Billiar TR. Inducible nitric oxide synthase is an endogenous neuroprotectant after traumatic brain injury in rats and mice. The Journal of Clinical Investigation. 104: 647-56. PMID 10487779 DOI: 10.1172/Jci6670  0.427
1999 Whalen MJ, Clark RS, Dixon CE, Robichaud P, Marion DW, Vagni V, Graham SH, Virag L, Hasko G, Stachlewitz R, Szabo C, Kochanek PM. Reduction of cognitive and motor deficits after traumatic brain injury in mice deficient in poly(ADP-ribose) polymerase. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 19: 835-42. PMID 10458590 DOI: 10.1097/00004647-199908000-00002  0.363
1999 Whalen MJ, Carlos TM, Kochanek PM, Clark RS, Heineman S, Schiding JK, Franicola D, Memarzadeh F, Lo W, Marion DW, Dekosky ST. Neutrophils do not mediate blood-brain barrier permeability early after controlled cortical impact in rats. Journal of Neurotrauma. 16: 583-94. PMID 10447070 DOI: 10.1089/Neu.1999.16.583  0.45
1999 Whalen MJ, Carlos TM, Clark RS, Kochanek PM. An acute inflammatory response to the use of granulocyte colony-stimulating factor to prevent infections in patients with brain injury: what about the brain? Critical Care Medicine. 27: 1014-8. PMID 10362429 DOI: 10.1097/00003246-199905000-00049  0.422
1999 Whalen MJ, Carlos TM, Dixon CE, Schiding JK, Clark RS, Baum E, Yan HQ, Marion DW, Kochanek PM. Effect of traumatic brain injury in mice deficient in intercellular adhesion molecule-1: assessment of histopathologic and functional outcome. Journal of Neurotrauma. 16: 299-309. PMID 10225216 DOI: 10.1089/Neu.1999.16.299  0.435
1999 Clark RS, Kochanek PM, Chen M, Watkins SC, Marion DW, Chen J, Hamilton RL, Loeffert JE, Graham SH. Increases in Bcl-2 and cleavage of caspase-1 and caspase-3 in human brain after head injury. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 13: 813-21. PMID 10224225 DOI: 10.1096/Fasebj.13.8.813  0.412
1999 Bell MJ, Kochanek PM, Heyes MP, Wisniewski SR, Sinz EH, Clark RS, Blight AR, Marion DW, Adelson PD. Quinolinic acid in the cerebrospinal fluid of children after traumatic brain injury. Critical Care Medicine. 27: 493-7. PMID 10199527 DOI: 10.1097/00003246-199903000-00023  0.437
1999 Dixon CE, Kochanek PM, Yan HQ, Schiding JK, Griffith RG, Baum E, Marion DW, DeKosky ST. One-year study of spatial memory performance, brain morphology, and cholinergic markers after moderate controlled cortical impact in rats. Journal of Neurotrauma. 16: 109-22. PMID 10098956 DOI: 10.1089/Neu.1999.16.109  0.376
1999 Kochanek P, Clark R, Dixon CE, Whalen M, Carlos T, Jackson E, Hendrich K, Ho C, Graham S, DeKosky S, Marion D. WHAT ARE THE KEY MECHANISMS OF SECONDARY DAMAGE AFTER TRAUMATIC BRAIN INJURY? Shock. 12: 5. DOI: 10.1097/00024382-199911001-00014  0.481
1999 Ruppel RA, Kochanek PM, Adelson PD, Bell MJ, Clark RSB, Janesko KL, Darnley AS, Berry SG, Marion DW. Endothelin-1 Is Increased In Cerebrospinal Fluid Following Traumatic Brain Injury In Children Critical Care Medicine. 27. DOI: 10.1097/00003246-199912001-00188  0.472
1999 Han YY, Carcillo JA, Ruppel RA, Adelson PD, Wisniewski SR, Bell MJ, Janesko KL, Marion DW, Kochanek PM. Cerebrospinal Fluid Procalcitonin Is Increased After Traumatic Brain Injury In Children Critical Care Medicine. 27. DOI: 10.1097/00003246-199912001-00184  0.468
1999 Whalen MJ, Carlos TM, Dixon CE, Robichaud P, Clark RSB, Marion DW, Kochanek PM. Reduced Brain Edema After Traumatic Brain Injury In Mice Deficient In P-Selectin And Inter-Cellular Adhesion Molecule-1 Critical Care Medicine. 27. DOI: 10.1097/00003246-199912001-00149  0.444
1999 Statler KD, Kochanek PM, Dixon CE, Alexander HL, Warner DS, Clark RSB, Wisniewski SR, Jenkins LW, Marion DW, Safar PJ. Isoflurane Improves Long-Term Neurologic Outcome Compared To Fentanyl After Traumatic Brain Injury In Rats Critical Care Medicine. 27. DOI: 10.1097/00003246-199912001-00063  0.451
1999 Seidberg NA, Graham SH, Kochanek PM, Dixon CE, Nathaniel PD, Melick J, Clark RSB. SYSTEMIC TREATMENT WITH A PAN-CASPASE INHIBITOR IMPROVES HIPPOCAMPAL NEURON SURVIVAL AFTER TRAUMATIC BRAIN INJURY IN MICE Critical Care Medicine. 27: A38. DOI: 10.1097/00003246-199912001-00062  0.416
1999 Robertson CL, Bell MJ, Kochanek PM, Adelson PD, Ruppel R, Wisniewski S, Mi Z, Janesko KL, Clark RSB, Jackson EK. INCREASED ADENOSINE CONCENTRATION IN CEREBROSPINAL FLUID AFTER SEVERE TRAUMATIC BRAIN INJURY IN INFANTS AND CHILDREN: ASSOCIATION WITH SEVERITY OF INJURY Critical Care Medicine. 27: A38. DOI: 10.1097/00003246-199912001-00061  0.463
1999 Seidberg NA, Clark RSB, Kochanek PM, Adelson PD, Satchell MA, Ruppel RA, Janesko KL, Graham SH. SOLUBLE FAS IS INCREASED IN CSF FROM INFANTS AND CHILDREN AFTER HEAD INJURY Critical Care Medicine. 27: A38. DOI: 10.1097/00003246-199912001-00060  0.357
1999 Satchell MA, Clark RSB, Chen M, John M, Szabo C, Kochanek PM. Poly(ADP-Ribose)synthetase activation and NAD depletion after traumatic brain injury in rats Critical Care Medicine. 27. DOI: 10.1097/00003246-199912001-00047  0.474
1999 Woods RJ, Prueckner S, Safar P, Takasu A, Tisherman SA, Jackson EK, Radovsky A, Kochanek P, Stezoski SW, Stezoski J. ADENOSINE BY AORTIC FLUSH FAILS TO AUGMENT THE BRAIN PRESERVATION EFFECT OF MILD HYPOTHERMIA DURING EXSANGUINATION CARDIAC ARREST IN DOGS Critical Care Medicine. 27: 106A. DOI: 10.1097/00003246-199901001-00271  0.347
1999 Clark RSB, Kochanek PM, Watkins SC, Chen M, Seidberg NA, Mellick J, Loeffert E, Graham SH. CASPASE-3 MEDIATED PROGRAMMED-CELL DEATH (APOPTOSIS) AFTER TRAUMATIC BRAIN INJURY IN RATS Critical Care Medicine. 27: 53A. DOI: 10.1097/00003246-199901001-00095  0.404
1999 Seidberg N, Clark R, Chen M, Marion D, Kochanek P, Graham S. INDUCIBLE 72kd HEAT SHOCK PROTEIN IS INCREASED AFTER TRAUMATIC BRAIN INJURY IN HUMANS Critical Care Medicine. 27: 51A. DOI: 10.1097/00003246-199901001-00085  0.432
1999 Whalen M, Chen M, Clark R, Jin K, Kochanek P, Marion D, Graham S. DNA DAMAGE IS TEMPERATURE DEPENDENT EARLY AFTER TRAUMATIC BRAIN INJURY IN RATS Critical Care Medicine. 27: 51A. DOI: 10.1097/00003246-199901001-00084  0.438
1998 Whalen MJ, Carlos TM, Kochanek PM, Wisniewski SR, Bell MJ, Carcillo JA, Clark RS, DeKosky ST, Adelson PD. Soluble adhesion molecules in CSF are increased in children with severe head injury. Journal of Neurotrauma. 15: 777-87. PMID 9814634 DOI: 10.1089/Neu.1998.15.777  0.441
1998 Whalen MJ, Carlos TM, Kochanek PM, Heineman S. Blood-brain barrier permeability, neutrophil accumulation and vascular adhesion molecule expression after controlled cortical impact in rats: a preliminary study. Acta Neurochirurgica. Supplement. 71: 212-4. PMID 9779187 DOI: 10.1007/978-3-7091-6475-4_61  0.36
1998 Adelson PD, Whalen MJ, Kochanek PM, Robichaud P, Carlos TM. Blood Brain Barrier Permeability and Acute Inflammation in Two Models of Traumatic Brain Injury in the Immature Rat: A Preliminary Report Acta Neurochirurgica, Supplement. 1998: 104-106. PMID 9779157 DOI: 10.1007/978-3-7091-6475-4_31  0.438
1998 Zou L, Burmeister LA, Styren SD, Kochanek PM, DeKosky ST. Up-regulation of type 2 iodothyronine deiodinase mRNA in reactive astrocytes following traumatic brain injury in the rat. Journal of Neurochemistry. 71: 887-90. PMID 9681483 DOI: 10.1046/J.1471-4159.1998.71020887.X  0.407
1998 Katz LM, Callaway CW, Kagan VE, Kochanek PM. Electron spin resonance measure of brain antioxidant activity during ischemia/reperfusion Neuroreport. 9: 1587-1593. PMID 9631471 DOI: 10.1097/00001756-199805110-00061  0.31
1998 Sinz EH, Kochanek PM, Heyes MP, Wisniewski SR, Bell MJ, Clark RS, DeKosky ST, Blight AR, Marion DW. Quinolinic acid is increased in CSF and associated with mortality after traumatic brain injury in humans. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 18: 610-5. PMID 9626184 DOI: 10.1097/00004647-199806000-00002  0.395
1998 Chen M, Clark RS, Kochanek PM, Chen J, Schiding JK, Stetler RA, Simon RP, Graham SH. 72-kDa heat shock protein and mRNA expression after controlled cortical impact injury with hypoxemia in rats. Journal of Neurotrauma. 15: 171-81. PMID 9528917 DOI: 10.1089/Neu.1998.15.171  0.365
1998 Bell MJ, Kochanek PM, Carcillo JA, Mi Z, Schiding JK, Wisniewski SR, Clark RS, Dixon CE, Marion DW, Jackson E. Interstitial adenosine, inosine, and hypoxanthine are increased after experimental traumatic brain injury in the rat. Journal of Neurotrauma. 15: 163-70. PMID 9528916 DOI: 10.1089/Neu.1998.15.163  0.462
1998 Goss JR, O'Malley ME, Zou L, Styren SD, Kochanek PM, DeKosky ST. Astrocytes are the major source of nerve growth factor upregulation following traumatic brain injury in the rat. Experimental Neurology. 149: 301-9. PMID 9500953 DOI: 10.1006/Exnr.1997.6712  0.423
1998 Forbes ML, Clark RS, Dixon CE, Graham SH, Marion DW, DeKosky ST, Schiding JK, Kochanek PM. Augmented neuronal death in CA3 hippocampus following hyperventilation early after controlled cortical impact. Journal of Neurosurgery. 88: 549-56. PMID 9488311 DOI: 10.3171/Jns.1998.88.3.0549  0.474
1998 Adelson PD, Kochanek PM. Head injury in children. Journal of Child Neurology. 13: 2-15. PMID 9477242 DOI: 10.1177/088307389801300102  0.459
1998 Whalen MJ, Carlos TM, Adelson PD, Bell MJ, DeKosky ST, Clark RS, Kochanek PM. Interleukin-8 is Increased in CSF of Children with Severe Traumatic Brain Injury |[bull]| 240 Pediatric Research. 43: 43-43. DOI: 10.1203/00006450-199804001-00261  0.401
1998 Bell M, Sinz E, Kochanek P, Adelson PD, Clark R, Wisniewski S, Blight A, Heyes M. Qutnolinic Acid In Cerebrospinal Fluid Of Children After Traumatic Brain Injury: A Preliminary Report Critical Care Medicine. 26. DOI: 10.1097/00003246-199801001-00225  0.452
1998 Whalen MJ, Carlos TM, Adelson PD, Bell MJ, DeKosky ST, Clark RSB, Kochanek PM. Interleukin-8 Is Increased In Csf Of Children With Severe Traumatic Brain Injury Critical Care Medicine. 26. DOI: 10.1097/00003246-199801001-00222  0.479
1998 Clark RSB, Kochanek PM, Marion DW, Chen M, Hamilton RL, Chen J, Graham SH. EXPRESSION OF THE bcl-2 FAMILY OF CELL DEATH REGULATORY PROTEINS AFTER HUMAN HEAD INJURY Critical Care Medicine. 26: 37A. DOI: 10.1097/00003246-199801001-00048  0.338
1998 Clark RSB, Kochanek PM, Carcillo JA, Bell MJ, Adelson PD, Whalen MJ, Wisniewski SR, Graham SH. APOPTOSIS-SUPPRESSOR PROTEIN bcl-2 IS INCREASED IN CEREBROSPINAL FLUID IN CHILDREN SURVIVING TRAUMATIC BRAIN INJURY Critical Care Medicine. 26: 37A. DOI: 10.1097/00003246-199801001-00047  0.438
1998 Sinz EH, Kochanek PM, Dixon CE, Clark RS, Carcillo JA, Watkins SC, Schiding J, Carlos TM, Billiar TR. INDUCIBLE NITRIC OXIDE SYNTHASE IS AN ENDOGENOUS NEUROPROTECTANT AFTER TRAUMATIC BRAIN INJURY IN RATS AND MICE Critical Care Medicine. 26: 36A. DOI: 10.1097/00003246-199801001-00044  0.443
1998 Bell M, Robertson C, Kochanek P, Goodman JC, Gopinpath S, Carcillo J, Clark R, Marion D, Mi Z, Jackson E. INTERSTITIAL BRAIN ADENOSINE DURING JUGULAR VENOUS DESATURATIONS AFTER HUMAN TRAUMATIC BRAIN INJURY (TBI) Critical Care Medicine. 26: 31A. DOI: 10.1097/00003246-199801001-00029  0.483
1997 Whalen MJ, Carlos TM, Clark RS, Marion DW, DeKosky MS, Heineman S, Schiding JK, Memarzadeh F, Dixon CE, Kochanek PM. The relationship between brain temperature and neutrophil accumulation after traumatic brain injury in rats. Acta Neurochirurgica. Supplement. 70: 260-1. PMID 9416340 DOI: 10.1007/978-3-7091-6837-0_80  0.473
1997 Kochanek PM, Clark RS, Obrist WD, Carcillo JA, Jackson EK, Mi Z, Wisniewski SR, Bell MJ, Marion DW. The role of adenosine during the period of delayed cerebral swelling after severe traumatic brain injury in humans. Acta Neurochirurgica. Supplement. 70: 109-11. PMID 9416294 DOI: 10.1007/978-3-7091-6837-0_34  0.409
1997 Bell MJ, Kochanek PM, Doughty LA, Carcillo JA, Adelson PD, Clark RS, Whalen MJ, DeKosky ST. Comparison of the interleukin-6 and interleukin-10 response in children after severe traumatic brain injury or septic shock. Acta Neurochirurgica. Supplement. 70: 96-7. PMID 9416290 DOI: 10.1007/978-3-7091-6837-0_30  0.351
1997 Clark RS, Carcillo JA, Kochanek PM, Obrist WD, Jackson EK, Mi Z, Wisneiwski SR, Bell MJ, Marion DW. Cerebrospinal fluid adenosine concentration and uncoupling of cerebral blood flow and oxidative metabolism after severe head injury in humans. Neurosurgery. 41: 1284-92; discussion . PMID 9402580 DOI: 10.1097/00006123-199712000-00010  0.377
1997 Whalen MJ, Carlos TM, Clark RS, Marion DW, DeKosky ST, Heineman S, Schiding JK, Memarzadeh F, Kochanek PM. The effect of brain temperature on acute inflammation after traumatic brain injury in rats. Journal of Neurotrauma. 14: 561-72. PMID 9300566 DOI: 10.1089/Neu.1997.14.561  0.384
1997 Forbes ML, Hendrich KS, Kochanek PM, Williams DS, Schiding JK, Wisniewski SR, Kelsey SF, DeKosky ST, Graham SH, Marion DW, Ho C. Assessment of cerebral blood flow and CO2 reactivity after controlled cortical impact by perfusion magnetic resonance imaging using arterial spin-labeling in rats. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 17: 865-74. PMID 9290584 DOI: 10.1097/00004647-199708000-00005  0.365
1997 Forbes ML, Hendrich KS, Schiding JK, Williams DS, Ho C, DeKosky ST, Marion DW, Kochanek PM. Perfusion MRI assessment of cerebral blood flow and CO2 reactivity after controlled cortical impact in rats. Advances in Experimental Medicine and Biology. 411: 7-12. PMID 9269406 DOI: 10.1007/978-1-4615-5865-1_2  0.476
1997 Bell MJ, Kochanek PM, Doughty LA, Carcillo JA, Adelson PD, Clark RS, Wisniewski SR, Whalen MJ, DeKosky ST. Interleukin-6 and interleukin-10 in cerebrospinal fluid after severe traumatic brain injury in children. Journal of Neurotrauma. 14: 451-7. PMID 9257663 DOI: 10.1089/Neu.1997.14.451  0.349
1997 Goss JR, Taffe KM, Kochanek PM, DeKosky ST. The antioxidant enzymes glutathione peroxidase and catalase increase following traumatic brain injury in the rat Experimental Neurology. 146: 291-294. PMID 9225764 DOI: 10.1006/Exnr.1997.6515  0.417
1997 Clark RS, Kochanek PM, Dixon CE, Chen M, Marion DW, Heineman S, DeKosky ST, Graham SH. Early neuropathologic effects of mild or moderate hypoxemia after controlled cortical impact injury in rats. Journal of Neurotrauma. 14: 179-89. PMID 9151767 DOI: 10.1089/Neu.1997.14.179  0.424
1997 Adelson PD, Dixon CE, Robichaud P, Kochanek PM. Motor and cognitive functional deficits following diffuse traumatic brain injury in the immature rat Journal of Neurotrauma. 14: 99-108. PMID 9069441 DOI: 10.1089/Neu.1997.14.99  0.362
1997 Carlos TM, Clark RS, Franicola-Higgins D, Schiding JK, Kochanek PM. Expression of endothelial adhesion molecules and recruitment of neutrophils after traumatic brain injury in rats. Journal of Leukocyte Biology. 61: 279-85. PMID 9060450 DOI: 10.1002/Jlb.61.3.279  0.346
1997 Marion DW, Penrod LE, Kelsey SF, Obrist WD, Kochanek PM, Palmer AM, Wisniewski SR, DeKosky ST. Treatment of traumatic brain injury with moderate hypothermia. The New England Journal of Medicine. 336: 540-6. PMID 9023090 DOI: 10.1056/Nejm199702203360803  0.466
1997 Clark RSB, Chen J, Watkins SC, Kochanek PM, Chen M, Stetler RA, Loeffert JE, Graham SH. Apoptosis-Suppressor Genebcl-2Expression after Traumatic Brain Injury in Rats The Journal of Neuroscience. 17: 9172-9182. DOI: 10.1523/Jneurosci.17-23-09172.1997  0.352
1997 Sinz EH, Kochanek PM, Heyes MP, Bell M, Wisniewski S, Clark RS, DeKosky ST, Blight AR, Marion DW. Quinolinic Acid Is Increased In Csf And Associated With Mortality In Human Head Injury Journal of Neurosurgical Anesthesiology. 9: 379. DOI: 10.1097/00008506-199710000-00018  0.355
1997 Safar P, Kochanek P, Marion D, Ebmeyer U, Pomeranz S. Resuscitative Moderate Hypothermia for Severe Traumatic Brain Injury Prehospital and Disaster Medicine. 12. DOI: 10.1017/S1049023X0004632X  0.505
1996 Dawson DA, Ruetzler CA, Carlos TM, Kochanek PM, Hallenbeck JM. Polymorphonuclear leukocytes and microcirculatory perfusion in acute stroke in the SHR. The Keio Journal of Medicine. 45: 248-52; discussion 2. PMID 8897768 DOI: 10.2302/Kjm.45.248  0.341
1996 Biagas KV, Grundl PD, Kochanek PM, Schiding JK, Nemoto EM. Posttraumatic hyperemia in immature, mature, and aged rats : Autoradiographic determination of cerebral blood flow Journal of Neurotrauma. 13: 189-200. PMID 8860199 DOI: 10.1089/Neu.1996.13.189  0.38
1996 Clark RS, Carlos TM, Schiding JK, Bree M, Fireman LA, DeKosky ST, Kochanek PM. Antibodies against Mac-1 attenuate neutrophil accumulation after traumatic brain injury in rats. Journal of Neurotrauma. 13: 333-41. PMID 8835801 DOI: 10.1089/Neu.1996.13.333  0.42
1996 Clark RS, Kochanek PM, Schwarz MA, Schiding JK, Turner DS, Chen M, Carlos TM, Watkins SC. Inducible nitric oxide synthase expression in cerebrovascular smooth muscle and neutrophils after traumatic brain injury in immature rats. Pediatric Research. 39: 784-90. PMID 8726229 DOI: 10.1203/00006450-199605000-00007  0.419
1996 Clark RS, Kochanek PM, Obrist WD, Wong HR, Billiar TR, Wisniewski SR, Marion DW. Cerebrospinal fluid and plasma nitrite and nitrate concentrations after head injury in humans. Critical Care Medicine. 24: 1243-51. PMID 8674343 DOI: 10.1097/00003246-199607000-00030  0.386
1996 Clark RS, Kochanek PM, Marion DW, Schiding JK, White M, Palmer AM, DeKosky ST. Mild posttraumatic hypothermia reduces mortality after severe controlled cortical impact in rats. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 16: 253-61. PMID 8594057 DOI: 10.1097/00004647-199603000-00010  0.362
1996 Mansfield RT, Schiding JK, Hamilton RL, Kochanek PM. Effects of hypothermia on traumatic brain injury in immature rats. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 16: 244-52. PMID 8594056 DOI: 10.1097/00004647-199603000-00009  0.393
1996 Dekosky ST, Styren SD, O'Malley ME, Goss JR, Kochanek P, Marion D, Evans CH, Robbins PD. Interleukin-1 receptor antagonist suppresses neurotrophin response in injured rat brain Annals of Neurology. 39: 123-127. PMID 8572657 DOI: 10.1002/Ana.410390118  0.335
1996 Whalen MJ, Carlos TM, Kochanek PM, Schiding JK, Clark RSB, DeKosky ST, Graham SH, Dixon CE, Marion DW. HYPOTHERMIA REDUCES ACUTE INFLAMMATION AFTER TRAUMATIC BRAIN INJURY IN RATS† 317 Pediatric Research. 39: 55-55. DOI: 10.1203/00006450-199604001-00337  0.498
1996 Adelson PD, Bell MJ, Jackson EK, Clark RSB, Mi Z, Carcillo JA, Kochanek PM. Increased Adenosine Concentrations in Cerebral Spinal Fluid After Severe Traumatic Brain Injury in Children Neurosurgery. 39: 644-644. DOI: 10.1097/00006123-199609000-00081  0.447
1996 Gisvold SE, Sterz F, Abramson NS, Bar-Joseph G, Ebmeyer U, Gervais H, Ginsberg M, Katz LM, Kochanek PM, Kuboyama K, Miller B, Obrist W, Roine RO, Safar P, Sim KM, et al. Cerebral resuscitation from cardiac arrest: treatment potentials. Critical Care Medicine. 24. DOI: 10.1097/00003246-199602000-00049  0.356
1996 Rosomoff HL, Kochanek PM, Clark R, DeKosky ST, Ebmeyer U, Grenvik ANA, Marion DW, Obrist W, Palmer AM, Safar P, White RJ. Resuscitation from severe brain trauma. Critical Care Medicine. 24. DOI: 10.1097/00003246-199602000-00047  0.508
1996 Wu X, Drabek T, Kochanek PM. Suspended Animation for Delayed Resuscitation Critical Care Medicine. 24: 298-312. DOI: 10.1007/0-387-26272-5_26  0.318
1995 Kochanek PM, Marion DW, Zhang W, Schiding JK, White M, Palmer AM, Clark RS, O'Malley ME, Styren SD, Ho C. Severe controlled cortical impact in rats: assessment of cerebral edema, blood flow, and contusion volume. Journal of Neurotrauma. 12: 1015-25. PMID 8742130 DOI: 10.1089/Neu.1995.12.1015  0.32
1995 Kaczorowski SL, Schiding JK, Toth CA, Kochanek PM. Effect of soluble complement receptor-1 on neutrophil accumulation after traumatic brain injury in rats. Journal of Cerebral Blood Flow and Metabolism. 15: 860-864. PMID 7673379 DOI: 10.1038/Jcbfm.1995.107  0.49
1995 Goss JR, Styren SD, Miller PD, Kochanek PM, Palmer AM, Marion DW, DeKosky ST. Hypothermia attenuates the normal increase in interleukin 1 beta RNA and nerve growth factor following traumatic brain injury in the rat. Journal of Neurotrauma. 12: 159-67. PMID 7629862 DOI: 10.1089/Neu.1995.12.159  0.403
1995 Clark R, Schiding J, Carlos T, Bree M, DeKosky S, Kochanek P. Mac-1 Antibodies Attenuate Neutrophil Accumulation After Traumatic Brain Injury In Rats. Critical Care Medicine. 23. DOI: 10.1097/00003246-199501001-00433  0.461
1995 Clark R, Carcillo J, Kochanek P, Mi Z, Jackson E, Marion D, Obrist W. CEREBROSPINAL FLUID ADENOSINE AND CEREBRAL BLOOD FLOW AND METABOLISM AFTER HUMAN HEAD INJURY. Critical Care Medicine. 23: A77. DOI: 10.1097/00003246-199501001-00113  0.356
1995 Clark R, Kochanek P, Wong HR, Billiar T, Mistrik M, Marion D, Obrist W. Cerebrospinal Fluid Nitrite/Nitrate And Cerebral Blood Flow After Human Head Injury. Critical Care Medicine. 23. DOI: 10.1097/00003246-199501001-00104  0.362
1994 Uhl MW, Biagas KV, Grundl PD, Barmada MA, Schiding JK, Nemoto EM, Kochanek PM. Effects of Neutropenia on Edema, Histology, and Cerebral Blood Flow After Traumatic Brain Injury in Rats Journal of Neurotrauma. 11: 303-315. PMID 7996584 DOI: 10.1089/Neu.1994.11.303  0.471
1994 Grundl PD, Biagas KV, Kochanek PM, Schiding JK, Barmada MA, Nemoto EM. Early Cerebrovascular Response to Head Injury in Immature and Mature Rats Journal of Neurotrauma. 11: 135-148. PMID 7932794 DOI: 10.1089/Neu.1994.11.135  0.418
1994 DeKosky ST, Goss JR, Miller PD, Styren SD, Kochanek PM, Marion D. Upregulation of Nerve Growth Factor Following Cortical Trauma Experimental Neurology. 130: 173-177. PMID 7867748 DOI: 10.1006/Exnr.1994.1196  0.399
1994 Clark RS, Schiding JK, Kaczorowski SL, Marion DW, Kochanek PM. Neutrophil accumulation after traumatic brain injury in rats: comparison of weight drop and controlled cortical impact models. Journal of Neurotrauma. 11: 499-506. PMID 7861443 DOI: 10.1089/Neu.1994.11.499  0.482
1994 Kaczorowski SL, Schiding JK, Kochanek PM. EFFECT OF sCR-1 ON BRAIN POLYMORPHONUCLEAR LEUKOCYTE ACCUMULATION AFTER BRAIN INJURY IN RATS Critical Care Medicine. 22. DOI: 10.1097/00003246-199401000-00427  0.474
1994 Mansfield R, Schiding J, Hamilton R, Kochanek P. Hypothermia Fails To Reduce Lesion Volume After Traumatic Brain Injury In Immature Rats Critical Care Medicine. 22. DOI: 10.1097/00003246-199401000-00325  0.459
1993 Kochanek PM. Ischemic and traumatic brain injury: pathobiology and cellular mechanisms. Critical Care Medicine. 21. PMID 8395991 DOI: 10.1097/00003246-199309001-00016  0.486
1993 Uhl MW, Kochanek PM, Schiding JK, Nemoto EM. Effect of phorbol myristate acetate on cerebral blood flow in normal and neutrophil-depleted rats. Stroke. 24: 1977-1982. PMID 8248980 DOI: 10.1161/01.Str.24.12.1977  0.313
1993 Kochanek P, Schiding J, Uhl M, Biagas K, Grundl P, Nemoto E. Neutrophils Contribute To Posttraumatic Hyperemia In Rat Brain Critical Care Medicine. 21. DOI: 10.1097/00003246-199304001-00253  0.371
1992 Singh NC, Kochanek PM, Schiding JK, Melick JA, Nemoto EM. Uncoupled cerebral blood flow and metabolism after severe global ischemia in rats. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 12: 802-8. PMID 1506444 DOI: 10.1038/Jcbfm.1992.111  0.335
1992 Biagas KV, Uhl MW, Schiding JK, Nemoto EM, Kochanek PM. Assessment of posttraumatic polymorphonuclear leukocyte accumulation in rat brain using tissue myeloperoxidase assay and vinblastine treatment. Journal of Neurotrauma. 9: 363-371. PMID 1337917 DOI: 10.1089/Neu.1992.9.363  0.396
1990 Schoettle RJ, Kochanek PM, Magargee MJ, Uhl MW, Nemoto EM. Early polymorphonuclear leukocyte accumulation correlates with the development of posttraumatic cerebral edema in rats. Journal of Neurotrauma. 7: 207-217. PMID 2127947 DOI: 10.1089/Neu.1990.7.207  0.337
1990 Uhl MW, Schoettle RJ, Kochanek PM, Magargce MJ, Nemoto EM. Neutropenia Does Not Prevent Post- Traumatic Cerebral Edema Critical Care Medicine. 18. DOI: 10.1097/00003246-199012001-00190  0.371
1989 Kochanek PM, Schoettle RJ, Nemoto EM, Barmada MA, Magargee MJ, Melick JA. Early Granulocyte Accumulation And Edema After Cerebral Trauma Anesthesiology. 71. DOI: 10.1097/00000542-198909001-00582  0.333
1988 Kochanek PM, Nemoto EM, Melick JA, Evans RW, Burke DF. Cerebrovascular and cerebrometabolic effects of intracarotid infused platelet-activating factor in rats. Journal of Cerebral Blood Flow and Metabolism. 8: 546-551. PMID 3392115 DOI: 10.1038/Jcbfm.1988.95  0.345
1988 Kochanek PM, Dutka AJ, Kumaroo KK, Hallenbeck JM. Effects of prostacyclin, indomethacin, and heparin on cerebral blood flow and platelet adhesion after multifocal ischemia of canine brain. Stroke. 19: 693-699. PMID 3287701 DOI: 10.1161/01.Str.19.6.693  0.3
1988 Kochanek PM. Novel pharmacologic approaches to brain resuscitation after cardiorespiratory arrest in the pediatric patient. Critical Care Clinics. 4: 661-677. DOI: 10.1016/S0749-0704(18)30461-5  0.417
1987 Kochanek PM, Dutka AJ, Hallenbeck JM. Indomethacin, prostacyclin, and heparin improve postischemic cerebral blood flow without affecting early postischemic granulocyte accumulation. Stroke. 18: 634-637. PMID 3296333 DOI: 10.1161/01.Str.18.3.634  0.334
1986 Hallenbeck JM, Dutka AJ, Tanishima T, Kochanek PM, Kumaroo KK, Thompson CB, Obrenovitch TP, Contreras TJ. Polymorphonuclear leukocyte accumulation in brain regions with low blood flow during the early postischemic period. Stroke. 17: 246-253. PMID 3961835 DOI: 10.1161/01.Str.17.2.246  0.339
1986 Kochanek PM, Dutka AJ, Hallenbeck JM. Bw 755C Prftreatment Fails To Inhibit Early Granulocyte Accumulation After Focal Brain Ischemia Critical Care Medicine. 14: 390. DOI: 10.1097/00003246-198604000-00156  0.363
1985 Kochanek PM, Dutka AJ, Tanishima T, Kumaroo KK, Hallenbeck JM. Combination Cyclooxygenase-Lipoxygenase Inhibition In The Resuscitation From Focal Brain Ischemia In Dogs Using Bw 755C, Prostacyclin, And Heparin Critical Care Medicine. 13: 287. DOI: 10.1097/00003246-198504000-00050  0.363
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