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Robert J. Nims - Publications

Affiliations: 
2010-2016 Biomedical Engineering Columbia University, New York, NY 
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31 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Savadipour A, Nims RJ, Rashidi N, Garcia-Castorena JM, Tang R, Marushack GK, Oswald SJ, Liedtke WB, Guilak F. Membrane stretch as the mechanism of activation of PIEZO1 ion channels in chondrocytes. Proceedings of the National Academy of Sciences of the United States of America. 120: e2221958120. PMID 37459546 DOI: 10.1073/pnas.2221958120  0.441
2021 Nims RJ, Pferdehirt L, Guilak F. Mechanogenetics: harnessing mechanobiology for cellular engineering. Current Opinion in Biotechnology. 73: 374-379. PMID 34735987 DOI: 10.1016/j.copbio.2021.09.011  0.436
2021 Klimak M, Nims RJ, Pferdehirt L, Collins KH, Harasymowicz NS, Oswald SJ, Setton LA, Guilak F. Immunoengineering the next generation of arthritis therapies. Acta Biomaterialia. PMID 33823324 DOI: 10.1016/j.actbio.2021.03.062  0.703
2021 Lee W, Nims RJ, Savadipour A, Zhang Q, Leddy HA, Liu F, McNulty AL, Chen Y, Guilak F, Liedtke WB. Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33758095 DOI: 10.1073/pnas.2001611118  0.778
2021 Nims RJ, Pferdehirt L, Ho NB, Savadipour A, Lorentz J, Sohi S, Kassab J, Ross AK, O'Conor CJ, Liedtke WB, Zhang B, McNulty AL, Guilak F. A synthetic mechanogenetic gene circuit for autonomous drug delivery in engineered tissues. Science Advances. 7. PMID 33571125 DOI: 10.1126/sciadv.abd9858  0.773
2021 Savadipour A, Nims RJ, Katz DB, Guilak F. Regulation of chondrocyte biosynthetic activity by dynamic hydrostatic pressure: the role of TRP channels. Connective Tissue Research. 1-13. PMID 33494617 DOI: 10.1080/03008207.2020.1871475  0.474
2020 Zimmerman B, Nims R, Chen A, Hung CT, Ateshian GA. Direct Osmotic Pressure Measurements in Articular Cartilage Demonstrate Non-Ideal and Concentration-Dependent Phenomena. Journal of Biomechanical Engineering. PMID 33210125 DOI: 10.1115/1.4049158  0.747
2020 Durney KM, Shaeffer CA, Zimmerman BK, Nims RJ, Oungoulian S, Jones BK, Boorman-Padgett JF, Suh JT, Shah RP, Hung CT, Ateshian GA. Immature bovine cartilage wear by fatigue failure and delamination. Journal of Biomechanics. 107: 109852. PMID 32517855 DOI: 10.1016/J.Jbiomech.2020.109852  0.745
2019 Guang Y, McGrath TM, Klug N, Nims R, Shih CC, Bayguinov PO, Guilak F, Pham CTN, Fitzpatrick JAJ, Setton LA. Combined Experimental Approach and Finite Element Modeling of Small Molecule Transport Through Joint Synovium to Measure Effective Diffusivity. Journal of Biomechanical Engineering. PMID 31536113 DOI: 10.1115/1.4044892  0.483
2019 Guilak F, Pferdehirt L, Ross AK, Choi YR, Collins KH, Nims RJ, Katz DB, Klimak M, Tabbaa S, Pham CT. Designer stem cells: Genome engineering and the next generation of cell-based therapies. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. PMID 30977548 DOI: 10.1002/Jor.24304  0.729
2018 Guilak F, Nims R, Dicks A, Wu CL, Meulenbelt I. Osteoarthritis as a disease of the cartilage pericellular matrix. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 29800616 DOI: 10.1016/J.Matbio.2018.05.008  0.748
2017 Nims RJ, Cigan AD, Durney KM, Jones BK, O'Neill JD, Law WA, Vunjak-Novakovic G, Hung CT, Ateshian GA. Constrained cage culture improves engineered cartilage functional properties by enhancing collagen network stability. Tissue Engineering. Part A. PMID 28193145 DOI: 10.1089/ten.TEA.2016.0467  0.782
2017 Nims RJ, Ateshian GA. Reactive Constrained Mixtures for Modeling the Solid Matrix of Biological Tissues Journal of Elasticity. 129: 69-105. DOI: 10.1007/S10659-017-9630-9  0.573
2016 Cigan AD, Durney KM, Nims RJ, Vunjak-Novakovic G, Hung CT, Ateshian GA. Nutrient Channels Aid the Growth of Articular Surface-Sized Engineered Cartilage Constructs. Tissue Engineering. Part A. PMID 27481330 DOI: 10.1089/Ten.Tea.2016.0179  0.796
2016 Cigan AD, Nims RJ, Vunjak-Novakovic G, Hung CT, Ateshian GA. Optimizing nutrient channel spacing and revisiting TGF-beta in large engineered cartilage constructs. Journal of Biomechanics. PMID 27255605 DOI: 10.1016/J.Jbiomech.2016.05.020  0.81
2016 Cigan AD, Roach BL, Nims RJ, Tan AR, Albro MB, Stoker AM, Cook JL, Vunjak-Novakovic G, Hung CT, Ateshian GA. High seeding density of human chondrocytes in agarose produces tissue-engineered cartilage approaching native mechanical and biochemical properties. Journal of Biomechanics. PMID 27198889 DOI: 10.1016/J.Jbiomech.2016.04.039  0.81
2016 Nims RJ, Durney KM, Cigan AD, Dusséaux A, Hung CT, Ateshian GA. Continuum theory of fibrous tissue damage mechanics using bond kinetics: application to cartilage tissue engineering. Interface Focus. 6: 20150063. PMID 26855751 DOI: 10.1098/Rsfs.2015.0063  0.777
2016 Nims RJ, Durney KM, Cigan AD, Dusséaux A, Hung CT, Ateshian GA. Continuum theory of fibrous tissue damage mechanics using bond kinetics: Application to cartilage tissue engineering Interface Focus. 6. DOI: 10.1098/rsfs.2015.0063  0.786
2015 Albro MB, Nims RJ, Durney KM, Cigan AD, Shim JJ, Vunjak-Novakovic G, Hung CT, Ateshian GA. Heterogeneous engineered cartilage growth results from gradients of media-supplemented active TGF-β and is ameliorated by the alternative supplementation of latent TGF-β. Biomaterials. 77: 173-185. PMID 26599624 DOI: 10.1016/J.Biomaterials.2015.10.018  0.79
2015 Nims RJ, Cigan AD, Albro MB, Vunjak-Novakovic G, Hung CT, Ateshian GA. Matrix Production in Large Engineered Cartilage Constructs Is Enhanced by Nutrient Channels and Excess Media Supply. Tissue Engineering. Part C, Methods. 21: 747-57. PMID 25526931 DOI: 10.1089/Ten.Tec.2014.0451  0.8
2014 Cigan AD, Nims RJ, Albro MB, Vunjak-Novakovic G, Hung CT, Ateshian GA. Nutrient channels and stirring enhanced the composition and stiffness of large cartilage constructs. Journal of Biomechanics. 47: 3847-54. PMID 25458579 DOI: 10.1016/J.Jbiomech.2014.10.017  0.797
2014 O'Connell GD, Nims RJ, Green J, Cigan AD, Ateshian GA, Hung CT. Time and dose-dependent effects of chondroitinase ABC on growth of engineered cartilage. European Cells & Materials. 27: 312-20. PMID 24760578 DOI: 10.22203/Ecm.V027A22  0.815
2014 Ateshian GA, Nims RJ, Maas S, Weiss JA. Computational modeling of chemical reactions and interstitial growth and remodeling involving charged solutes and solid-bound molecules. Biomechanics and Modeling in Mechanobiology. 13: 1105-20. PMID 24558059 DOI: 10.1007/S10237-014-0560-1  0.562
2014 Nims RJ, Cigan AD, Albro MB, Hung CT, Ateshian GA. Synthesis rates and binding kinetics of matrix products in engineered cartilage constructs using chondrocyte-seeded agarose gels. Journal of Biomechanics. 47: 2165-72. PMID 24284199 DOI: 10.1016/J.Jbiomech.2013.10.044  0.798
2013 Albro MB, Nims RJ, Cigan AD, Yeroushalmi KJ, Alliston T, Hung CT, Ateshian GA. Accumulation of exogenous activated TGF-β in the superficial zone of articular cartilage. Biophysical Journal. 104: 1794-804. PMID 23601326 DOI: 10.1016/J.Bpj.2013.02.052  0.804
2013 Cigan AD, Nims RJ, Albro MB, Esau JD, Dreyer MP, Vunjak-Novakovic G, Hung CT, Ateshian GA. Insulin, ascorbate, and glucose have a much greater influence than transferrin and selenous acid on the in vitro growth of engineered cartilage in chondrogenic media. Tissue Engineering. Part A. 19: 1941-8. PMID 23544890 DOI: 10.1089/Ten.Tea.2012.0596  0.763
2013 Albro MB, Nims RJ, Cigan AD, Yeroushalmi KJ, Shim JJ, Hung CT, Ateshian GA. Dynamic mechanical compression of devitalized articular cartilage does not activate latent TGF-β. Journal of Biomechanics. 46: 1433-9. PMID 23540376 DOI: 10.1016/J.Jbiomech.2013.03.006  0.807
2013 Nims RJ, Cigan AD, Albro MB, Hung CT, Ateshian GA. Binding and release kinetics of glycosaminoglycans and collagen in engineered cartilage under TGF-β supplementation Asme 2013 Summer Bioengineering Conference, Sbc 2013. 1. DOI: 10.1115/SBC2013-14660  0.796
2013 Cigan AD, Nims RJ, Albro MB, Hung CT, Ateshian GA. Effects of media stirring and presence of nutrient channels on functional properties of large engineered cartilage constructs Asme 2013 Summer Bioengineering Conference, Sbc 2013. 1. DOI: 10.1115/SBC2013-14128  0.793
2012 Albro MB, Cigan AD, Nims RJ, Yeroushalmi KJ, Oungoulian SR, Hung CT, Ateshian GA. Shearing of synovial fluid activates latent TGF-β. Osteoarthritis and Cartilage / Oars, Osteoarthritis Research Society. 20: 1374-82. PMID 22858668 DOI: 10.1016/J.Joca.2012.07.006  0.759
2012 Ateshian GA, Nims R, Cigan AD, Albro MB, Hung CT. Finite element modeling of matrix synthesis and binding kinetics in a biphasic-solute material Asme 2012 Summer Bioengineering Conference, Sbc 2012. 1019-1020. DOI: 10.1115/SBC2012-80485  0.751
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