| Year |
Citation |
Score |
| 2023 |
Mays SG, Hercules D, Ortlund EA, Okafor CD. The nuclear receptor LRH-1 discriminates between ligands using distinct allosteric signaling circuits. Protein Science : a Publication of the Protein Society. e4754. PMID 37572334 DOI: 10.1002/pro.4754 |
0.543 |
|
| 2023 |
Mays SG, Hercules D, Ortlund EA, Okafor CD. The nuclear receptor LRH-1 discriminates between ligands using distinct allosteric signaling circuits. Biorxiv : the Preprint Server For Biology. PMID 36747705 DOI: 10.1101/2023.01.27.525934 |
0.542 |
|
| 2022 |
Cato ML, Cornelison JL, Spurlin RM, Courouble VV, Patel AB, Flynn AR, Johnson AM, Okafor CD, Frank F, D'Agostino EH, Griffin PR, Jui NT, Ortlund EA. Differential Modulation of Nuclear Receptor LRH-1 through Targeting Buried and Surface Regions of the Binding Pocket. Journal of Medicinal Chemistry. PMID 35503419 DOI: 10.1021/acs.jmedchem.2c00235 |
0.557 |
|
| 2022 |
Mays SG, D'Agostino EH, Flynn AR, Huang X, Wang G, Liu X, Millings EJ, Okafor CD, Patel A, Cato ML, Cornelison JL, Melchers D, Houtman R, Moore DD, Calvert JW, et al. A phospholipid mimetic targeting LRH-1 ameliorates colitis. Cell Chemical Biology. PMID 35316658 DOI: 10.1016/j.chembiol.2022.03.001 |
0.56 |
|
| 2020 |
Moody JC, Qadota H, Reedy AR, Okafor CD, Shanmugan N, Matsunaga Y, Christian CJ, Ortlund EA, Benian GM. The Rho-GEF PIX-1 directs assembly or stability of lateral attachment structures between muscle cells. Nature Communications. 11: 5010. PMID 33024114 DOI: 10.1038/s41467-020-18852-4 |
0.486 |
|
| 2020 |
Tillman MC, Imai N, Li Y, Khadka M, Okafor CD, Juneja P, Adhiyaman A, Hagen SJ, Cohen DE, Ortlund EA. Allosteric regulation of thioesterase superfamily member 1 by lipid sensor domain binding fatty acids and lysophosphatidylcholine. Proceedings of the National Academy of Sciences of the United States of America. PMID 32820071 DOI: 10.1073/Pnas.2003877117 |
0.577 |
|
| 2020 |
Guth-Metzler R, Bray MS, Frenkel-Pinter M, Suttapitugsakul S, Montllor-Albalate C, Bowman JC, Wu R, Reddi AR, Okafor CD, Glass JB, Williams LD. Cutting in-line with iron: ribosomal function and non-oxidative RNA cleavage. Nucleic Acids Research. PMID 32663277 DOI: 10.1093/Nar/Gkaa586 |
0.727 |
|
| 2019 |
Okafor CD, Hercules D, Kell SA, Ortlund EA. Rewiring Ancient Residue Interaction Networks Drove the Evolution of Specificity in Steroid Receptors. Structure (London, England : 1993). PMID 31831214 DOI: 10.1016/J.Str.2019.11.012 |
0.585 |
|
| 2019 |
Mays S, Flynn AR, Cornelison J, Okafor CD, Wang H, Wang G, Huang X, Donaldson H, Millings E, Polavarapu R, Moore D, Calvert J, Jui NT, Ortlund EA. Development of the first low nanomolar Liver Receptor Homolog-1 agonist through structure-guided design. Journal of Medicinal Chemistry. PMID 31419141 DOI: 10.1021/Acs.Jmedchem.9B00753 |
0.534 |
|
| 2019 |
Okafor CD, Colucci JK, Ortlund EA. Ligand-Induced Allosteric Effects Governing SR Signaling Nuclear Receptor Research. 6. DOI: 10.32527/2019/101382 |
0.59 |
|
| 2018 |
Frank F, Okafor CD, Ortlund EA. The first crystal structure of a DNA-free nuclear receptor DNA binding domain sheds light on DNA-driven allostery in the glucocorticoid receptor. Scientific Reports. 8: 13497. PMID 30201977 DOI: 10.1038/S41598-018-31812-9 |
0.607 |
|
| 2018 |
Okafor CD, Pathak MC, Fagan CE, Bauer NC, Cole MF, Gaucher EA, Ortlund EA. Structural and Dynamics Comparison of Thermostability in Ancient, Modern, and Consensus Elongation Factor Tus. Structure (London, England : 1993). 26: 118-129.e3. PMID 29276038 DOI: 10.1016/J.Str.2017.11.018 |
0.564 |
|
| 2017 |
Mays SG, Okafor CD, Tuntland ML, Whitby RJ, Dharmarajan V, Stec J, Griffin PR, Ortlund EA. Structure and Dynamics of the Liver Receptor Homolog 1-PGC1α Complex. Molecular Pharmacology. PMID 28363985 DOI: 10.1124/Mol.117.108514 |
0.608 |
|
| 2017 |
Okafor CD, Lanier KA, Petrov AS, Athavale SS, Bowman JC, Hud NV, Williams LD. Iron mediates catalysis of nucleic acid processing enzymes: support for Fe(II) as a cofactor before the great oxidation event. Nucleic Acids Research. PMID 28334877 DOI: 10.1093/Nar/Gkx171 |
0.704 |
|
| 2017 |
Mays SG, Okafor CD, Whitby RJ, Goswami D, Stec J, Flynn AR, Dugan MC, Jui NT, Griffin PR, Ortlund EA. Targeting the nuclear receptor LRH-1 with synthetic agonists Acta Crystallographica Section a Foundations and Advances. 73: a98-a98. DOI: 10.1107/S0108767317099020 |
0.549 |
|
| 2016 |
Mays SG, Okafor CD, Whitby RJ, Goswami D, Stec JO, Flynn AR, Dugan MC, Jui NT, Griffin PR, Ortlund EA. Crystal Structures of the Nuclear Receptor, Liver Receptor Homolog 1, Bound to Synthetic Agonists Reveal a Novel Mechanism of Activation. The Journal of Biological Chemistry. PMID 27694446 DOI: 10.1074/Jbc.M116.753541 |
0.603 |
|
| 2016 |
Gulen B, Petrov AS, Okafor CD, Vander Wood D, O'Neill EB, Hud NV, Williams LD. Ribosomal small subunit domains radiate from a central core. Scientific Reports. 6: 20885. PMID 26876483 DOI: 10.1038/Srep20885 |
0.683 |
|
| 2013 |
Hsiao C, Chou IC, Okafor CD, Bowman JC, O'Neill EB, Athavale SS, Petrov AS, Hud NV, Wartell RM, Harvey SC, Williams LD. RNA with iron(II) as a cofactor catalyses electron transfer. Nature Chemistry. 5: 525-8. PMID 23695635 DOI: 10.1038/Nchem.1649 |
0.714 |
|
| 2012 |
Petrov AS, Bernier CR, Hsiao C, Okafor CD, Tannenbaum E, Stern J, Gaucher E, Schneider D, Hud NV, Harvey SC, Williams LD. RNA-magnesium-protein interactions in large ribosomal subunit. The Journal of Physical Chemistry. B. 116: 8113-20. PMID 22712611 DOI: 10.1021/Jp304723W |
0.695 |
|
| 2012 |
Engelhart AE, Cafferty BJ, Okafor CD, Chen MC, Williams LD, Lynn DG, Hud NV. Nonenzymatic ligation of DNA with a reversible step and a final linkage that can be used in PCR. Chembiochem : a European Journal of Chemical Biology. 13: 1121-4. PMID 22556064 DOI: 10.1002/Cbic.201200167 |
0.665 |
|
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