| Year |
Citation |
Score |
| 2020 |
Riva V, Garbelli A, Brai A, Casiraghi F, Fazi R, Trivisani CI, Boccuto A, Saladini F, Vicenti I, Martelli F, Zazzi M, Giannecchini S, Dreassi E, Botta M, Maga G. Unique Domain for a Unique Target: Selective Inhibitors of Host Cell DDX3X to Fight Emerging Viruses. Journal of Medicinal Chemistry. PMID 32787106 DOI: 10.1021/Acs.Jmedchem.0C01039 |
0.382 |
|
| 2020 |
de Souza ACA, Mori M, Sens L, Rocha RF, Tizziani T, de Souza LFS, Domeneghini Chiaradia-Delatorre L, Botta M, Nunes RJ, Terenzi H, Menegatti ACO. A chalcone derivative binds a putative allosteric site of YopH: Inhibition of a virulence factor of Yersinia. Bioorganic & Medicinal Chemistry Letters. 30: 127350. PMID 32631548 DOI: 10.1016/J.Bmcl.2020.127350 |
0.37 |
|
| 2020 |
Brai A, Riva V, Saladini F, Zamperini C, Trivisani CI, Garbelli A, Pennisi C, Giannini A, Boccuto A, Bugli F, Martini M, Sanguinetti M, Zazzi M, Dreassi E, Botta M, et al. DDX3X inhibitors, an effective way to overcome HIV-1 resistance targeting host proteins. European Journal of Medicinal Chemistry. 200: 112319. PMID 32446036 DOI: 10.1016/J.Ejmech.2020.112319 |
0.327 |
|
| 2020 |
Brai A, Boccuto A, Monti M, Marchi S, Vicenti I, Saladini F, Trivisani CI, Pollutri A, Trombetta CM, Montomoli E, Riva V, Garbelli A, Nola EM, Zazzi M, Maga G, ... ... Botta M, et al. Exploring the Implication of DDX3X in DENV Infection: Discovery of the First-in-Class DDX3X Fluorescent Inhibitor. Acs Medicinal Chemistry Letters. 11: 956-962. PMID 32435411 DOI: 10.1021/Acsmedchemlett.9B00681 |
0.365 |
|
| 2020 |
Borgini M, Zamperini C, Poggialini F, Ferrante L, Summa V, Botta M, Fabio RD. Synthesis and Antiproliferative Activity of Nitric Oxide-Donor Largazole Prodrugs. Acs Medicinal Chemistry Letters. 11: 846-851. PMID 32435394 DOI: 10.1021/Acsmedchemlett.9B00643 |
0.788 |
|
| 2020 |
Malancona S, Mori M, Fezzardi P, Santoriello M, Basta A, Nibbio M, Kovalenko L, Speziale R, Battista MR, Cellucci A, Gennari N, Monteagudo E, Di Marco A, Giannini A, Sharma R, ... ... Botta M, et al. 5,6-Dihydroxypyrimidine Scaffold to Target HIV-1 Nucleocapsid Protein. Acs Medicinal Chemistry Letters. 11: 766-772. PMID 32435383 DOI: 10.1021/Acsmedchemlett.9B00608 |
0.386 |
|
| 2020 |
Diukendjieva A, Zaharieva MM, Mori M, Alov P, Tsakovska I, Pencheva T, Najdenski H, Křen V, Felici C, Bufalieri F, Di Marcotullio L, Botta B, Botta M, Pajeva I. Dual SMO/BRAF Inhibition by Flavonolignans from . Antioxidants (Basel, Switzerland). 9. PMID 32380762 DOI: 10.3390/Antiox9050384 |
0.38 |
|
| 2020 |
Iralde-Lorente L, Tassone G, Clementi L, Franci L, Munier CC, Cau Y, Mori M, Chiariello M, Angelucci A, Perry MWD, Pozzi C, Mangani S, Botta M. Identification of phosphate-containing compounds as new inhibitors of 14-3-3/c-Abl protein-protein interaction. Acs Chemical Biology. PMID 32142251 DOI: 10.1021/Acschembio.0C00039 |
0.389 |
|
| 2020 |
Batista FAH, Ramos SL, Tassone G, Leitão A, Montanari CA, Botta M, Mori M, Borges JC. Discovery of small molecule inhibitors of Hsp90 chaperone. Journal of Enzyme Inhibition and Medicinal Chemistry. 35: 639-649. PMID 32048531 DOI: 10.1080/14756366.2020.1726342 |
0.321 |
|
| 2020 |
Humbert N, Kovalenko L, Saladini F, Giannini A, Pires M, Botzanowski T, Cherenok S, Boudier C, Sharma KK, Real E, Zaporozhets OA, Cianférani S, Seguin-Devaux C, Poggialini F, Botta M, et al. (Thia)calixarenephosphonic acids as potent inhibitors of the nucleic acid chaperone activity of the HIV-1 nucleocapsid protein with a new binding mode and multi-target antiviral activity. Acs Infectious Diseases. PMID 32045204 DOI: 10.1021/Acsinfecdis.9B00290 |
0.407 |
|
| 2019 |
Orofino F, Truglio GI, Fiorucci D, D'Agostino I, Borgini M, Poggialini F, Zamperini C, Dreassi E, Maccari L, Torelli R, Martini C, Bernabei M, Meis JF, Khandelwal NK, Prasad R, ... ... Botta M, et al. In vitro characterization, ADME analysis, histological and toxicological evaluation of BM1, a macrocyclic amidinourea active against azole-resistant Candida strains. International Journal of Antimicrobial Agents. 105865. PMID 31866465 DOI: 10.1016/J.Ijantimicag.2019.105865 |
0.773 |
|
| 2019 |
Brai A, Ronzini S, Riva V, Botta L, Zamperini C, Borgini M, Trivisani CI, Garbelli A, Pennisi C, Boccuto A, Saladini F, Zazzi M, Maga G, Botta M. Synthesis and Antiviral Activity of Novel 1,3,4-Thiadiazole Inhibitors of DDX3X. Molecules (Basel, Switzerland). 24. PMID 31690062 DOI: 10.3390/Molecules24213988 |
0.808 |
|
| 2019 |
Fallacara AL, Passannanti R, Mori M, Iovenitti G, Musumeci F, Greco C, Crespan E, Kissova M, Maga G, Tarantelli C, Spriano F, Gaudio E, Bertoni F, Botta M, Schenone S. Identification of a new family of pyrazolo[3,4-d]pyrimidine derivatives as multitarget Fyn-Blk-Lyn inhibitors active on B- and T-lymphoma cell lines. European Journal of Medicinal Chemistry. 181: 111545. PMID 31400706 DOI: 10.1016/J.Ejmech.2019.07.048 |
0.369 |
|
| 2019 |
Zaayter L, Mori M, Ahmad T, Ashraf W, Boudier C, Kilin V, Gavvala K, Richert L, Eiler S, Ruff M, Botta M, Bronner C, Mousli M, Mely Y. A molecular tool targeting the base flipping activity of human UHRF1. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 31322780 DOI: 10.1002/Chem.201902605 |
0.323 |
|
| 2019 |
Fallacara AL, Zamperini C, Podolski-Renić A, Dinić J, Stanković T, Stepanović M, Mancini A, Rango E, Iovenitti G, Molinari A, Bugli F, Sanguinetti M, Torelli R, Martini M, Maccari L, ... ... Botta M, et al. A New Strategy for Glioblastoma Treatment: In Vitro and In Vivo Preclinical Characterization of Si306, a Pyrazolo[3,4-]Pyrimidine Dual Src/P-Glycoprotein Inhibitor. Cancers. 11. PMID 31248184 DOI: 10.3390/Cancers11060848 |
0.332 |
|
| 2019 |
Ku T, Lopresti N, Shirley M, Mori M, Marchant J, Heng X, Botta M, Summers MF, Seley-Radtke KL. Synthesis of distal and proximal fleximer base analogues and evaluation in the nucleocapsid protein of HIV-1. Bioorganic & Medicinal Chemistry. PMID 31126822 DOI: 10.1016/J.Bmc.2019.05.019 |
0.349 |
|
| 2019 |
Mori M, Dasso Lang MC, Saladini F, Palombi N, Kovalenko L, De Forni D, Poddesu B, Friggeri L, Giannini A, Malancona S, Summa V, Zazzi M, Mely Y, Botta M. Synthesis and Evaluation of Bifunctional Aminothiazoles as Antiretrovirals Targeting the HIV-1 Nucleocapsid Protein. Acs Medicinal Chemistry Letters. 10: 463-468. PMID 30996780 DOI: 10.1021/Acsmedchemlett.8B00506 |
0.366 |
|
| 2019 |
Iralde-Lorente L, Cau Y, Clementi L, Franci L, Tassone G, Valensin D, Mori M, Angelucci A, Chiariello M, Botta M. Chemically stable inhibitors of 14-3-3 protein-protein interactions derived from BV02. Journal of Enzyme Inhibition and Medicinal Chemistry. 34: 657-664. PMID 30727786 DOI: 10.1080/14756366.2019.1574779 |
0.366 |
|
| 2019 |
Brai A, Martelli F, Riva V, Garbelli A, Fazi R, Zamperini C, Pollutri A, Falsitta L, Ronzini S, Maccari L, Maga G, Giannecchini S, Botta M. DDX3X helicase inhibitors as new strategy to fight West Nile Virus infection. Journal of Medicinal Chemistry. PMID 30721061 DOI: 10.1021/Acs.Jmedchem.8B01403 |
0.363 |
|
| 2019 |
Crescenza A, Botta M, Corelli F, Santini A, Tafi A. Cyclic Dipeptides. 3.(1) Synthesis of Methyl (R)-6-[(tert-Butoxycarbonyl)amino]-4,5,6,7- tetrahydro-2-methyl-5-oxo-1,4-thiazepine-3-carboxylate and Its Hexahydro Analogues: Elaboration of a Novel Dual ACE/NEP Inhibitor. The Journal of Organic Chemistry. 64: 3019-3025. PMID 11674397 DOI: 10.1021/Jo981425V |
0.399 |
|
| 2019 |
Borgini M, Orofino F, Truglio GI, Balestri L, Botta M. A gram-scale synthesis of a macrocyclic amidinourea with strong antifungal activity through a Fukuyama tri-protected polyamine intermediate Arkivoc. 2019: 168-177. DOI: 10.24820/Ark.5550190.P010.895 |
0.777 |
|
| 2019 |
Roversi FM, Bueno MLP, Torello CO, Della Via FI, Rosa RG, Bianco JER, Duarte ASS, Rego EM, Molinari A, Botta M, Olalla Saad ST. A Novel Chemical Compound Inhibiting Hematopoietic Cell Kinase (iHCK) Has a Synergic Effect with Azacytidine (Aza) or Cytarabine (Ara-C) for Acute Myeloid Leukemia Treatment Blood. 134: 4650-4650. DOI: 10.1182/Blood-2019-128959 |
0.319 |
|
| 2019 |
Mancini A, Fallacara AL, Zamperini C, Iovenitti G, Molinari A, Rango E, Angelucci A, Schenone S, Botta M. Abstract 2201: Preclinical development of novel pyrazolo[3,4-d]pyrimidines structure-based TKIs for the treatment of glioblastoma Cancer Research. 79: 2201-2201. DOI: 10.1158/1538-7445.Am2019-2201 |
0.407 |
|
| 2018 |
Cagno V, Tintori C, Civra A, Cavalli R, Tiberi M, Botta L, Brai A, Poli G, Tapparel C, Lembo D, Botta M. Novel broad spectrum virucidal molecules against enveloped viruses. Plos One. 13: e0208333. PMID 30532192 DOI: 10.1371/Journal.Pone.0208333 |
0.31 |
|
| 2018 |
Ibrahim HS, Eldehna WM, Fallacara AL, Ahmed ER, Ghabbour HA, Elaasser MM, Botta M, Abou-Seri SM, Abdel-Aziz HA. One-pot synthesis of spiro(indoline-3,4'-pyrazolo[3,4-b]pyridine)-5'-carbonitriles as p53-MDM2 interaction inhibitors. Future Medicinal Chemistry. PMID 30526032 DOI: 10.4155/Fmc-2018-0288 |
0.325 |
|
| 2018 |
Pasero C, D'Agostino I, DE Luca F, Zamperini C, Deodato D, Truglio GI, Sannio F, Del Prete R, Ferraro T, Visaggio D, Mancini A, Guglielmi MB, Visca P, Docquier JD, Botta M. Alkyl-guanidine compounds as potent broad-spectrum antibacterial agents: chemical library extension and biological characterization. Journal of Medicinal Chemistry. PMID 30265809 DOI: 10.1021/Acs.Jmedchem.8B00619 |
0.388 |
|
| 2018 |
Molinari A, Fallacara AL, Di Maria S, Zamperini C, Poggialini F, Musumeci F, Schenone S, Angelucci A, Colapietro A, Crespan E, Kissova M, Maga G, Botta M. Efficient optimization of pyrazolo[3,4-d]pyrimidines derivatives as c-Src kinase inhibitors in neuroblastoma treatment. Bioorganic & Medicinal Chemistry Letters. 28: 3454-3457. PMID 30262428 DOI: 10.1016/J.Bmcl.2018.09.024 |
0.339 |
|
| 2018 |
Tassone G, Mangani S, Botta M, Pozzi C. Probing the role of Arg97 in Heat shock protein 90 N-terminal domain from the parasite Leishmania braziliensis through site-directed mutagenesis on the human counterpart. Biochimica Et Biophysica Acta. Proteins and Proteomics. 1866: 1190-1198. PMID 30248409 DOI: 10.1016/J.Bbapap.2018.09.005 |
0.314 |
|
| 2018 |
D'Agostino I, Giacchello I, Nannetti G, Fallacara AL, Deodato D, Musumeci F, Grossi G, Palù G, Cau Y, Trist IM, Loregian A, Schenone S, Botta M. Synthesis and biological evaluation of a library of hybrid derivatives as inhibitors of influenza virus PA-PB1 interaction. European Journal of Medicinal Chemistry. 157: 743-758. PMID 30142611 DOI: 10.1016/J.Ejmech.2018.08.032 |
0.387 |
|
| 2018 |
Calandro P, Iovenitti G, Zamperini C, Candita F, Dreassi E, Chiariello M, Angelucci A, Schenone S, Botta M, Mancini A. Plasmin-Binding Tripeptide-Decorated Liposomes Loading Pyrazolo[3,4-]pyrimidines for Targeting Hepatocellular Carcinoma. Acs Medicinal Chemistry Letters. 9: 646-651. PMID 30034594 DOI: 10.1021/Acsmedchemlett.8B00062 |
0.314 |
|
| 2018 |
Friggeri L, Hargrove TY, Wawrzak Z, Blobaum AL, Rachakonda G, Lindsley CW, Villalta F, Nes WD, Botta M, Guengerich FP, Lepesheva GI. Sterol 14α-Demethylase Structure-Based Design of VNI ((R)-N-(1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives to Target Fungal Infections: Synthesis, Biological Evaluation, and Crystallographic Analysis. Journal of Medicinal Chemistry. PMID 29894182 DOI: 10.1021/Acs.Jmedchem.8B00641 |
0.409 |
|
| 2018 |
Tintori C, Iovenitti G, Ceresola ER, Ferrarese R, Zamperini C, Brai A, Poli G, Dreassi E, Cagno V, Lembo D, Canducci F, Botta M. Rhodanine derivatives as potent anti-HIV and anti-HSV microbicides. Plos One. 13: e0198478. PMID 29870553 DOI: 10.1371/Journal.Pone.0198478 |
0.381 |
|
| 2018 |
Mori M, Deodato D, Kasula M, Ferraris DM, Sanna A, De Logu A, Rizzi M, Botta M. Design, synthesis, SAR and biological investigation of 3-(carboxymethyl)rhodanine and aminothiazole inhibitors of Mycobacterium tuberculosis Zmp1. Bioorganic & Medicinal Chemistry Letters. 28: 637-641. PMID 29395975 DOI: 10.1016/J.Bmcl.2018.01.031 |
0.368 |
|
| 2017 |
Gamba E, Mori M, Kovalenko L, Giannini A, Sosic A, Saladini F, Fabris D, Mély Y, Gatto B, Botta M. Identification of novel 2-benzoxazolinone derivatives with specific inhibitory activity against the HIV-1 nucleocapsid protein. European Journal of Medicinal Chemistry. 145: 154-164. PMID 29324338 DOI: 10.1016/J.Ejmech.2017.12.073 |
0.405 |
|
| 2017 |
Mascarello A, Orbem Menegatti AC, Calcaterra A, Martins PGA, Chiaradia-Delatorre LD, D'Acquarica I, Ferrari F, Pau V, Sanna A, De Logu A, Botta M, Botta B, Terenzi H, Mori M. Naturally occurring Diels-Alder-type adducts from Morus nigra as potent inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B. European Journal of Medicinal Chemistry. 144: 277-288. PMID 29275228 DOI: 10.1016/J.Ejmech.2017.11.087 |
0.357 |
|
| 2017 |
Cau Y, Vullo D, Mori M, Dreassi E, Supuran CT, Botta M. Potent and Selective Carboxylic Acid Inhibitors of Tumor-Associated Carbonic Anhydrases IX and XII. Molecules (Basel, Switzerland). 23. PMID 29271882 DOI: 10.3390/Molecules23010017 |
0.323 |
|
| 2017 |
Mori M, Kovalenko L, Malancona S, Saladini F, De Forni D, Pires M, Humbert N, Real E, Botzanowski T, Cianférani S, Giannini A, Dasso Lang MC, Cugia G, Poddesu B, Lori F, ... ... Botta M, et al. Structure-Based Identification of HIV-1 Nucleocapsid Protein Inhibitors Active against Wild-Type and Drug-Resistant HIV-1 Strains. Acs Chemical Biology. PMID 29235845 DOI: 10.1021/Acschembio.7B00907 |
0.363 |
|
| 2017 |
Poli G, Di Fabio R, Ferrante L, Summa V, Botta M. Largazole Analogues as Histone Deacetylase Inhibitors and Anticancer Agents: An Overview of Structure-Activity Relationships. Chemmedchem. 12: 1917-1926. PMID 29117473 DOI: 10.1002/Cmdc.201700563 |
0.424 |
|
| 2017 |
Zamperini C, Maccari G, Deodato D, Pasero C, D'Agostino I, Orofino F, De Luca F, Dreassi E, Docquier JD, Botta M. Identification, synthesis and biological activity of alkyl-guanidine oligomers as potent antibacterial agents. Scientific Reports. 7: 8251. PMID 28811659 DOI: 10.1038/S41598-017-08749-6 |
0.44 |
|
| 2017 |
Laschi M, Bernardini G, Geminiani M, Manetti F, Mori M, Spreafico A, Campanacci D, Capanna R, Schenone S, Botta M, Santucci A. Differentially activated Src kinase in chemo-naïve human primary osteosarcoma cells and effects of a Src kinase inhibitor. Biofactors (Oxford, England). 43: 801-811. PMID 28786551 DOI: 10.1002/Biof.1382 |
0.307 |
|
| 2017 |
Berrino E, Bua S, Mori M, Botta M, Murthy VS, Vijayakumar V, Tamboli Y, Bartolucci G, Mugelli A, Cerbai E, Supuran CT, Carta F. Novel Sulfamide-Containing Compounds as Selective Carbonic Anhydrase I Inhibitors. Molecules (Basel, Switzerland). 22. PMID 28672822 DOI: 10.3390/Molecules22071049 |
0.39 |
|
| 2017 |
Vignaroli G, Iovenitti G, Zamperini C, Coniglio F, Calandro P, Molinari A, Fallacara AL, Sartucci A, Calgani A, Colecchia D, Mancini A, Festuccia C, Dreassi E, Valoti M, Musumeci F, ... ... Botta M, et al. Prodrugs of pyrazolo[3,4-d]pyrimidines: from library synthesis to evaluation as potential anticancer agents in an orthotopic glioblastoma model. Journal of Medicinal Chemistry. PMID 28650650 DOI: 10.1021/Acs.Jmedchem.7B00637 |
0.363 |
|
| 2017 |
Maccari G, Deodato D, Fiorucci D, Orofino F, Truglio GI, Pasero C, Martini R, De Luca F, Docquier JD, Botta M. Design and synthesis of a novel inhibitor of T. Viride chitinase through an in silico target fishing protocol. Bioorganic & Medicinal Chemistry Letters. PMID 28610983 DOI: 10.1016/J.Bmcl.2017.06.016 |
0.408 |
|
| 2017 |
Madia VN, Benedetti R, Barreca ML, Ngo L, Pescatori L, Messore A, Pupo G, Saccoliti F, Valente S, Mai A, Scipione L, Zheng YG, Tintori C, Botta M, Cecchetti V, et al. Structure-Activity Relationships on Cynnamoyl Derivatives as Inhibitors of p300 Histone Acetyltransferase. Chemmedchem. PMID 28346821 DOI: 10.1002/Cmdc.201700040 |
0.369 |
|
| 2017 |
Martini R, Esposito F, Corona A, Ferrarese R, Ceresola ER, Visconti L, Tintori C, Barbieri A, Calcaterra A, Iovine V, Canducci F, Tramontano E, Botta M. Natural Product Kuwanon-L Inhibits HIV-1 Replication through Multiple Target Binding. Chembiochem : a European Journal of Chemical Biology. 18: 374-377. PMID 27992102 DOI: 10.1002/Cbic.201600592 |
0.366 |
|
| 2016 |
Laurenzana I, Caivano A, La Rocca F, Trino S, De Luca L, D'Alessio F, Schenone S, Falco G, Botta M, Del Vecchio L, Musto P. A Pyrazolo[3,4-d]pyrimidine Compound Reduces Cell Viability and Induces Apoptosis in Different Hematological Malignancies. Frontiers in Pharmacology. 7: 416. PMID 27872592 DOI: 10.3389/Fphar.2016.00416 |
0.362 |
|
| 2016 |
Laurenzana I, Caivano A, Trino S, De Luca L, La Rocca F, Simeon V, Tintori C, D'Alessio F, Teramo A, Zambello R, Traficante A, Maietti M, Semenzato G, Schenone S, Botta M, et al. A Pyrazolo[3,4-d]pyrimidine compound inhibits Fyn phosphorylation and induces apoptosis in natural killer cell leukemia. Oncotarget. PMID 27566560 DOI: 10.18632/Oncotarget.11496 |
0.346 |
|
| 2016 |
Cau Y, Mori M, Supuran CT, Botta M. Mycobacterial carbonic anhydrase inhibition with phenolic acids and esters: kinetic and computational investigations. Organic & Biomolecular Chemistry. PMID 27530867 DOI: 10.1039/C6Ob01477A |
0.348 |
|
| 2016 |
Musso L, Cincinelli R, Zuco V, De Cesare M, Zunino F, Fallacara AL, Botta M, Dallavalle S. 3-Arylidene-N-hydroxyoxindoles: A New Class of Compounds Endowed with Antitumor Activity. Chemmedchem. 11: 1700-4. PMID 27311681 DOI: 10.1002/Cmdc.201600225 |
0.363 |
|
| 2016 |
De Vita D, Pandolfi F, Cirilli R, Scipione L, Di Santo R, Friggeri L, Mori M, Fiorucci D, Maccari G, Arul Christopher RS, Zamperini C, Pau V, De Logu A, Tortorella S, Botta M. Discovery of in vitro antitubercular agents through in silico ligand-based approaches. European Journal of Medicinal Chemistry. 121: 169-180. PMID 27240272 DOI: 10.1016/J.Ejmech.2016.05.032 |
0.367 |
|
| 2016 |
Brai A, Fazi R, Tintori C, Zamperini C, Bugli F, Sanguinetti M, Stigliano E, Esté J, Badia R, Franco S, Martinez MA, Martinez JP, Meyerhans A, Saladini F, Zazzi M, ... ... Botta M, et al. Human DDX3 protein is a valuable target to develop broad spectrum antiviral agents. Proceedings of the National Academy of Sciences of the United States of America. PMID 27118832 DOI: 10.1073/Pnas.1522987113 |
0.343 |
|
| 2016 |
Deodato D, Maccari G, De Luca F, Sanfilippo S, Casian A, Martini R, D'Arezzo S, Bonchi C, Bugli F, Posteraro B, Vandeputte P, Sanglard D, Docquier JD, Sanguinetti M, Visca P, ... Botta M, et al. Biological Characterization and in Vivo Assessment of the Activity of a New Synthetic Macrocyclic Antifungal Compound. Journal of Medicinal Chemistry. 59: 3854-66. PMID 27045868 DOI: 10.1021/Acs.Jmedchem.6B00018 |
0.376 |
|
| 2016 |
Indovina P, Casini N, Forte IM, Garofano T, Cesari D, Iannuzzi CA, Del Porro L, Pentimalli F, Napoliello L, Boffo S, Schenone S, Botta M, Giordano A. SRC Family Kinase Inhibition in Ewing Sarcoma Cells Induces p38 MAP Kinase-Mediated Cytotoxicity and Reduces Cell Migration. Journal of Cellular Physiology. PMID 27037775 DOI: 10.1002/Jcp.25397 |
0.313 |
|
| 2016 |
Ortiz C, Moraca F, Medeiros A, Botta M, Hamilton N, Comini MA. Binding Mode and Selectivity of Steroids towards Glucose-6-phosphate Dehydrogenase from the Pathogen Trypanosoma cruzi. Molecules (Basel, Switzerland). 21. PMID 26999093 DOI: 10.3390/Molecules21030368 |
0.319 |
|
| 2016 |
Laschi M, Bernardini G, Dreassi E, Millucci L, Geminiani M, Braconi D, Marzocchi B, Botta M, Manetti F, Santucci A. Inhibition of para-Hydroxyphenylpyruvate Dioxygenase by Analogues of the Herbicide Nitisinone As a Strategy to Decrease Homogentisic Acid Levels, the Causative Agent of Alkaptonuria. Chemmedchem. 11: 674-8. PMID 26947423 DOI: 10.1002/Cmdc.201500578 |
0.356 |
|
| 2016 |
Tintori C, Corona A, Esposito F, Brai A, Grandi N, Ceresola ER, Clementi M, Canducci F, Tramontano E, Botta M. Inhibition of HIV-1 Reverse Transcriptase Dimerization by Small Molecules. Chembiochem : a European Journal of Chemical Biology. PMID 26946324 DOI: 10.1002/Cbic.201500668 |
0.38 |
|
| 2016 |
Trist IM, Nannetti G, Tintori C, Fallacara AL, Deodato D, Mercorelli B, Palù G, Wijtmans M, Gospodova T, Edink E, Verheij M, de Esch I, Viteva L, Loregian A, Botta M. 4,6-Diphenylpyridines as Promising Novel Anti-Influenza Agents Targeting the PA-PB1 Protein-Protein Interaction: Structure-Activity Relationships Exploration with the Aid of Molecular Modeling. Journal of Medicinal Chemistry. 59: 2688-703. PMID 26924568 DOI: 10.1021/Acs.Jmedchem.5B01935 |
0.368 |
|
| 2016 |
Tintori C, Brai A, Dasso Lang MC, Deodato D, Greco AM, Bizzarri BM, Cascone L, Casian A, Zamperini C, Dreassi E, Crespan E, Maga G, Vanham G, Ceresola E, Canducci F, ... ... Botta M, et al. Development and in Vitro Evaluation of a Microbicide Gel Formulation for a Novel Non-Nucleoside Reverse Transcriptase Inhibitor Belonging to the N-Dihydroalkyloxybenzyloxopyrimidines (N-DABOs) Family. Journal of Medicinal Chemistry. 59: 2747-59. PMID 26898379 DOI: 10.1021/Acs.Jmedchem.5B01979 |
0.364 |
|
| 2016 |
Vignaroli G, Calandro P, Zamperini C, Coniglio F, Iovenitti G, Tavanti M, Colecchia D, Dreassi E, Valoti M, Schenone S, Chiariello M, Botta M. Improvement of pyrazolo[3,4-d]pyrimidines pharmacokinetic properties: nanosystem approaches for drug delivery. Scientific Reports. 6: 21509. PMID 26898318 DOI: 10.1038/Srep21509 |
0.346 |
|
| 2016 |
Valensin D, Cau Y, Calandro P, Vignaroli G, Dello Iacono L, Chiariello M, Mori M, Botta M. Molecular insights to the bioactive form of BV02, a reference inhibitor of 14-3-3σ protein-protein interactions. Bioorganic & Medicinal Chemistry Letters. 26: 894-8. PMID 26774582 DOI: 10.1016/J.Bmcl.2015.12.066 |
0.316 |
|
| 2015 |
Christodoulou MS, Mori M, Pantano R, Alfonsi R, Infante P, Botta M, Damia G, Ricci F, Sotiropoulou PA, Liekens S, Botta B, Passarella D. Click Reaction as a Tool to Combine Pharmacophores: The Case of Vismodegib. Chempluschem. 80: 938-943. PMID 31973263 DOI: 10.1002/Cplu.201402435 |
0.379 |
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| 2015 |
Fazi R, Tintori C, Brai A, Botta L, Selvaraj M, Garbelli A, Maga G, Botta M. Homology Model-Based Virtual Screening for the Identification of Human Helicase DDX3 Inhibitors. Journal of Chemical Information and Modeling. 55: 2443-54. PMID 26544088 DOI: 10.1021/Acs.Jcim.5B00419 |
0.366 |
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| 2015 |
Francini CM, Fallacara AL, Artusi R, Mennuni L, Calgani A, Angelucci A, Schenone S, Botta M. Identification of Aminoimidazole and Aminothiazole Derivatives as Src Family Kinase Inhibitors. Chemmedchem. PMID 26514807 DOI: 10.1002/Cmdc.201500428 |
0.422 |
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| 2015 |
Esposito F, Tintori C, Martini R, Christ F, Debyser Z, Ferrarese R, Cabiddu G, Corona A, Ceresola ER, Calcaterra A, Iovine V, Botta B, Clementi M, Canducci F, Botta M, et al. Kuwanon-L as a New Allosteric HIV-1 Integrase Inhibitor: Molecular Modeling and Biological Evaluation. Chembiochem : a European Journal of Chemical Biology. PMID 26360521 DOI: 10.1002/Cbic.201500385 |
0.358 |
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| 2015 |
Tintori C, Esposito F, Morreale F, Martini R, Tramontano E, Botta M. Investigation on the sucrose binding pocket of HIV-1 Integrase by molecular dynamics and synergy experiments. Bioorganic & Medicinal Chemistry Letters. 25: 3013-6. PMID 26048795 DOI: 10.1016/J.Bmcl.2015.05.011 |
0.328 |
|
| 2015 |
Tintori C, La Sala G, Vignaroli G, Botta L, Fallacara AL, Falchi F, Radi M, Zamperini C, Dreassi E, Dello Iacono L, Orioli D, Biamonti G, Garbelli M, Lossani A, Gasparrini F, ... ... Botta M, et al. Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors. Journal of Medicinal Chemistry. 58: 4590-609. PMID 25923950 DOI: 10.1021/Acs.Jmedchem.5B00140 |
0.38 |
|
| 2015 |
Casini N, Forte IM, Mastrogiovanni G, Pentimalli F, Angelucci A, Festuccia C, Tomei V, Ceccherini E, Di Marzo D, Schenone S, Botta M, Giordano A, Indovina P. SRC family kinase (SFK) inhibition reduces rhabdomyosarcoma cell growth in vitro and in vivo and triggers p38 MAP kinase-mediated differentiation. Oncotarget. 6: 12421-35. PMID 25762618 DOI: 10.18632/Oncotarget.3043 |
0.304 |
|
| 2015 |
Mori M, Kovalenko L, Lyonnais S, Antaki D, Torbett BE, Botta M, Mirambeau G, Mély Y. Nucleocapsid Protein: A Desirable Target for Future Therapies Against HIV-1. Current Topics in Microbiology and Immunology. 389: 53-92. PMID 25749978 DOI: 10.1007/82_2015_433 |
0.357 |
|
| 2015 |
Ceccherini E, Indovina P, Zamperini C, Dreassi E, Casini N, Cutaia O, Forte IM, Pentimalli F, Esposito L, Polito MS, Schenone S, Botta M, Giordano A. SRC family kinase inhibition through a new pyrazolo[3,4-d]pyrimidine derivative as a feasible approach for glioblastoma treatment. Journal of Cellular Biochemistry. 116: 856-63. PMID 25521525 DOI: 10.1002/Jcb.25042 |
0.331 |
|
| 2015 |
Tintori C, Fallacara AL, Radi M, Zamperini C, Dreassi E, Crespan E, Maga G, Schenone S, Musumeci F, Brullo C, Richters A, Gasparrini F, Angelucci A, Festuccia C, Delle Monache S, ... ... Botta M, et al. Combining X-ray crystallography and molecular modeling toward the optimization of pyrazolo[3,4-d]pyrimidines as potent c-Src inhibitors active in vivo against neuroblastoma. Journal of Medicinal Chemistry. 58: 347-61. PMID 25469771 DOI: 10.1021/Jm5013159 |
0.394 |
|
| 2015 |
Laurenzana I, Caivano A, La Rocca F, Trino S, De Luca L, D'Alessio F, Tintori C, Simeon V, Traficante A, Teramo A, Zambello R, Semenzato G, Schenone S, Botta M, Musto P, et al. A Pyrazolo[3,4-d]Pyrimidine Compound Reduces Fyn Phosphorylation and Induces Apoptosis in Large Granular Lymphocyte Leukemia Cells Blood. 126: 3254-3254. DOI: 10.1182/Blood.V126.23.3254.3254 |
0.312 |
|
| 2014 |
Maccari G, Sanfilippo S, De Luca F, Deodato D, Casian A, Dasso Lang MC, Zamperini C, Dreassi E, Rossolini GM, Docquier JD, Botta M. Synthesis of linear and cyclic guazatine derivatives endowed with antibacterial activity. Bioorganic & Medicinal Chemistry Letters. 24: 5525-9. PMID 25455183 DOI: 10.1016/J.Bmcl.2014.09.081 |
0.351 |
|
| 2014 |
Famiglini V, La Regina G, Coluccia A, Pelliccia S, Brancale A, Maga G, Crespan E, Badia R, Riveira-Muñoz E, Esté JA, Ferretti R, Cirilli R, Zamperini C, Botta M, Schols D, et al. Indolylarylsulfones carrying a heterocyclic tail as very potent and broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitors. Journal of Medicinal Chemistry. 57: 9945-57. PMID 25418038 DOI: 10.1021/Jm5011622 |
0.382 |
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| 2014 |
Moraca F, De Vita D, Pandolfi F, Di Santo R, Costi R, Cirilli R, D'Auria FD, Panella S, Palamara AT, Simonetti G, Botta M, Scipione L. Synthesis, biological evaluation and structure-activity correlation study of a series of imidazol-based compounds as Candida albicans inhibitors. European Journal of Medicinal Chemistry. 83: 665-73. PMID 25010937 DOI: 10.1016/J.Ejmech.2014.07.001 |
0.382 |
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| 2014 |
Tintori C, Brai A, Fallacara AL, Fazi R, Schenone S, Botta M. Protein-protein interactions and human cellular cofactors as new targets for HIV therapy. Current Opinion in Pharmacology. 18: 1-8. PMID 24993074 DOI: 10.1016/J.Coph.2014.06.005 |
0.318 |
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| 2014 |
Bechi B, Amantini D, Tintori C, Botta M, Fabio Rd. Stereocontrolled synthesis of 5-azaspiro[2.3]hexane derivatives as conformationally "frozen" analogues of L-glutamic acid. Beilstein Journal of Organic Chemistry. 10: 1114-20. PMID 24991261 DOI: 10.3762/Bjoc.10.110 |
0.323 |
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| 2014 |
Mori M, Nucci A, Lang MC, Humbert N, Boudier C, Debaene F, Sanglier-Cianferani S, Catala M, Schult-Dietrich P, Dietrich U, Tisné C, Mely Y, Botta M. Functional and structural characterization of 2-amino-4-phenylthiazole inhibitors of the HIV-1 nucleocapsid protein with antiviral activity. Acs Chemical Biology. 9: 1950-5. PMID 24988251 DOI: 10.1021/Cb500316H |
0.419 |
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| 2014 |
Botta M. New frontiers in kinases: special issue. Acs Medicinal Chemistry Letters. 5: 270. PMID 24900819 DOI: 10.1021/Ml500071M |
0.33 |
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| 2014 |
Schenone S, Radi M, Musumeci F, Brullo C, Botta M. Biologically driven synthesis of pyrazolo[3,4-d]pyrimidines as protein kinase inhibitors: an old scaffold as a new tool for medicinal chemistry and chemical biology studies. Chemical Reviews. 114: 7189-238. PMID 24873489 DOI: 10.1021/Cr400270Z |
0.362 |
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| 2014 |
Zamperini C, Dreassi E, Vignaroli G, Radi M, Dragoni S, Schenone S, Musumeci F, Valoti M, Antiochia R, Botta M. CYP-dependent metabolism of antitumor pyrazolo[3,4-d]pyrimidine derivatives is characterized by an oxidative dechlorination reaction. Drug Metabolism and Pharmacokinetics. 29: 433-40. PMID 24850316 DOI: 10.2133/Dmpk.Dmpk-13-Rg-094 |
0.329 |
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| 2014 |
Fallacara AL, Tintori C, Radi M, Schenone S, Botta M. Insight into the allosteric inhibition of Abl kinase. Journal of Chemical Information and Modeling. 54: 1325-38. PMID 24787133 DOI: 10.1021/Ci500060K |
0.366 |
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| 2014 |
Mori M, Moraca F, Deodato D, Ferraris DM, Selchow P, Sander P, Rizzi M, Botta M. Discovery of the first potent and selective Mycobacterium tuberculosis Zmp1 inhibitor. Bioorganic & Medicinal Chemistry Letters. 24: 2508-11. PMID 24767848 DOI: 10.1016/J.Bmcl.2014.04.004 |
0.338 |
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| 2014 |
Mori M, Vignaroli G, Cau Y, Dinić J, Hill R, Rossi M, Colecchia D, Pešić M, Link W, Chiariello M, Ottmann C, Botta M. Discovery of 14-3-3 protein-protein interaction inhibitors that sensitize multidrug-resistant cancer cells to doxorubicin and the Akt inhibitor GSK690693. Chemmedchem. 9: 973-83. PMID 24715717 DOI: 10.1002/Cmdc.201400044 |
0.376 |
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| 2014 |
Bernardini G, Laschi M, Serchi T, Spreafico A, Botta M, Schenone S, Arena S, Geminiani M, Scaloni A, Collodel G, Orlandini M, Niccolai N, Santucci A. Proteomics and phosphoproteomics provide insights into the mechanism of action of a novel pyrazolo[3,4-d]pyrimidine Src inhibitor in human osteosarcoma. Molecular Biosystems. 10: 1305-12. PMID 24615350 DOI: 10.1039/C3Mb70328B |
0.317 |
|
| 2014 |
Tiberi M, Tintori C, Ceresola ER, Fazi R, Zamperini C, Calandro P, Franchi L, Selvaraj M, Botta L, Sampaolo M, Saita D, Ferrarese R, Clementi M, Canducci F, Botta M. 2-Aminothiazolones as anti-HIV agents that act as gp120-CD4 inhibitors. Antimicrobial Agents and Chemotherapy. 58: 3043-52. PMID 24614386 DOI: 10.1128/Aac.02739-13 |
0.351 |
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| 2014 |
Vignaroli G, Mencarelli M, Sementa D, Crespan E, Kissova M, Maga G, Schenone S, Radi M, Botta M. Exploring the chemical space around the privileged pyrazolo[3,4-d]pyrimidine scaffold: toward novel allosteric inhibitors of T315I-mutated Abl. Acs Combinatorial Science. 16: 168-75. PMID 24597676 DOI: 10.1021/Co500004E |
0.404 |
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| 2014 |
Tintori C, Laurenzana I, Fallacara AL, Kessler U, Pilger B, Stergiou L, Botta M. High-throughput docking for the identification of new influenza A virus polymerase inhibitors targeting the PA-PB1 protein-protein interaction. Bioorganic & Medicinal Chemistry Letters. 24: 280-2. PMID 24314669 DOI: 10.1016/J.Bmcl.2013.11.019 |
0.368 |
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| 2014 |
Pagano M, Castagnolo D, Bernardini M, Fallacara AL, Laurenzana I, Deodato D, Kessler U, Pilger B, Stergiou L, Strunze S, Tintori C, Botta M. The fight against the influenza A virus H1N1: synthesis, molecular modeling, and biological evaluation of benzofurazan derivatives as viral RNA polymerase inhibitors. Chemmedchem. 9: 129-50. PMID 24285596 DOI: 10.1002/Cmdc.201300378 |
0.651 |
|
| 2013 |
Sanguinetti M, Sanfilippo S, Castagnolo D, Sanglard D, Posteraro B, Donzellini G, Botta M. Novel Macrocyclic Amidinoureas: Potent Non-Azole Antifungals Active against Wild-Type and Resistant Candida Species. Acs Medicinal Chemistry Letters. 4: 852-7. PMID 24900759 DOI: 10.1021/Ml400187W |
0.684 |
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| 2013 |
Vignaroli G, Zamperini C, Dreassi E, Radi M, Angelucci A, Sanità P, Crespan E, Kissova M, Maga G, Schenone S, Musumeci F, Botta M. Pyrazolo[3,4-d]pyrimidine Prodrugs: Strategic Optimization of the Aqueous Solubility of Dual Src/Abl Inhibitors. Acs Medicinal Chemistry Letters. 4: 622-6. PMID 24900720 DOI: 10.1021/Ml4000782 |
0.414 |
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| 2013 |
Peruzzotti C, Borrelli S, Ventura M, Pantano R, Fumagalli G, Christodoulou MS, Monticelli D, Luzzani M, Fallacara AL, Tintori C, Botta M, Passarella D. Probing the binding site of abl tyrosine kinase using in situ click chemistry. Acs Medicinal Chemistry Letters. 4: 274-7. PMID 24900659 DOI: 10.1021/Ml300394W |
0.361 |
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| 2013 |
Bellucci L, Angeli L, Tafi A, Radi M, Botta M. Unconventional plasticity of HIV-1 reverse transcriptase: how inhibitors could open a connection "gate" between allosteric and catalytic sites. Journal of Chemical Information and Modeling. 53: 3117-22. PMID 24256065 DOI: 10.1021/Ci400414S |
0.319 |
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| 2013 |
Mascarello A, Mori M, Chiaradia-Delatorre LD, Menegatti AC, Delle Monache F, Ferrari F, Yunes RA, Nunes RJ, Terenzi H, Botta B, Botta M. Discovery of Mycobacterium tuberculosis protein tyrosine phosphatase B (PtpB) inhibitors from natural products. Plos One. 8: e77081. PMID 24155919 DOI: 10.1371/Journal.Pone.0077081 |
0.392 |
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| 2013 |
Kessler U, Castagnolo D, Pagano M, Deodato D, Bernardini M, Pilger B, Ranadheera C, Botta M. Discovery and synthesis of novel benzofurazan derivatives as inhibitors of influenza A virus. Bioorganic & Medicinal Chemistry Letters. 23: 5575-7. PMID 24012120 DOI: 10.1016/J.Bmcl.2013.08.048 |
0.681 |
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| 2013 |
Tintori C, Laurenzana I, La Rocca F, Falchi F, Carraro F, Ruiz A, Esté JA, Kissova M, Crespan E, Maga G, Biava M, Brullo C, Schenone S, Botta M. Identification of Hck inhibitors as hits for the development of antileukemia and anti-HIV agents. Chemmedchem. 8: 1353-60. PMID 23813855 DOI: 10.1002/Cmdc.201300204 |
0.435 |
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| 2013 |
Radi M, Tintori C, Musumeci F, Brullo C, Zamperini C, Dreassi E, Fallacara AL, Vignaroli G, Crespan E, Zanoli S, Laurenzana I, Filippi I, Maga G, Schenone S, Angelucci A, ... Botta M, et al. Design, synthesis, and biological evaluation of pyrazolo[3,4-d]pyrimidines active in vivo on the Bcr-Abl T315I mutant. Journal of Medicinal Chemistry. 56: 5382-94. PMID 23746084 DOI: 10.1021/Jm400233W |
0.395 |
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| 2013 |
Baiocco P, Poce G, Alfonso S, Cocozza M, Porretta GC, Colotti G, Biava M, Moraca F, Botta M, Yardley V, Fiorillo A, Lantella A, Malatesta F, Ilari A. Inhibition of Leishmania infantum trypanothione reductase by azole-based compounds: a comparative analysis with its physiological substrate by X-ray crystallography. Chemmedchem. 8: 1175-83. PMID 23733388 DOI: 10.1002/Cmdc.201300176 |
0.397 |
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| 2013 |
Botta M, Forli S, Magnani M, Manetti F. Molecular modeling approaches to study the binding mode on tubulin of microtubule destabilizing and stabilizing agents. Topics in Current Chemistry. 286: 279-328. PMID 23563616 DOI: 10.1007/128_2008_20 |
0.362 |
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| 2013 |
Poce G, Bates RH, Alfonso S, Cocozza M, Porretta GC, Ballell L, Rullas J, Ortega F, De Logu A, Agus E, La Rosa V, Pasca MR, De Rossi E, Wae B, Franzblau SG, ... ... Botta M, et al. Improved BM212 MmpL3 inhibitor analogue shows efficacy in acute murine model of tuberculosis infection. Plos One. 8: e56980. PMID 23437287 DOI: 10.1371/Journal.Pone.0056980 |
0.398 |
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| 2013 |
Mori M, Tintori C, Christopher RS, Radi M, Schenone S, Musumeci F, Brullo C, Sanità P, Delle Monache S, Angelucci A, Kissova M, Crespan E, Maga G, Botta M. A combination strategy to inhibit Pim-1: synergism between noncompetitive and ATP-competitive inhibitors. Chemmedchem. 8: 484-96. PMID 23436791 DOI: 10.1002/Cmdc.201200480 |
0.378 |
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| 2013 |
Tintori C, Selvaraj M, Badia R, Clotet B, Esté JA, Botta M. Computational studies identifying entry inhibitor scaffolds targeting the Phe43 cavity of HIV-1 gp120. Chemmedchem. 8: 475-83. PMID 23404750 DOI: 10.1002/Cmdc.201200584 |
0.353 |
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| 2013 |
Strambi A, Mori M, Rossi M, Colecchia D, Manetti F, Carlomagno F, Botta M, Chiariello M. Structure prediction and validation of the ERK8 kinase domain. Plos One. 8: e52011. PMID 23326322 DOI: 10.1371/Journal.Pone.0052011 |
0.337 |
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| 2013 |
Radi M, Schenone S, Botta M. Allosteric inhibitors of Bcr-Abl: towards novel myristate-pocket binders. Current Pharmaceutical Biotechnology. 14: 477-87. PMID 22429131 DOI: 10.2174/138920101405131111103750 |
0.366 |
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| 2013 |
Radi M, Bernardo V, Vignaroli G, Brai A, Biava M, Schenone S, Botta M. An alternative synthetic approach for the synthesis of biologically relevant 1,4-disubstituted pyrazolo[3,4-d]pyrimidines Tetrahedron Letters. 54: 5204-5206. DOI: 10.1016/J.Tetlet.2013.07.069 |
0.336 |
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| 2012 |
Radi M, Evensen L, Dreassi E, Zamperini C, Caporicci M, Falchi F, Musumeci F, Schenone S, Lorens JB, Botta M. A combined targeted/phenotypic approach for the identification of new antiangiogenics agents active on a zebrafish model: from in silico screening to cyclodextrin formulation. Bioorganic & Medicinal Chemistry Letters. 22: 5579-83. PMID 22853993 DOI: 10.1016/J.Bmcl.2012.07.014 |
0.322 |
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| 2012 |
Colombo F, Tintori C, Furlan A, Borrelli S, Christodoulou MS, Dono R, Maina F, Botta M, Amat M, Bosch J, Passarella D. 'Click' synthesis of a triazole-based inhibitor of Met functions in cancer cells. Bioorganic & Medicinal Chemistry Letters. 22: 4693-6. PMID 22738633 DOI: 10.1016/J.Bmcl.2012.05.078 |
0.403 |
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| 2012 |
Mori M, Schult-Dietrich P, Szafarowicz B, Humbert N, Debaene F, Sanglier-Cianferani S, Dietrich U, Mély Y, Botta M. Use of virtual screening for discovering antiretroviral compounds interacting with the HIV-1 nucleocapsid protein. Virus Research. 169: 377-87. PMID 22634301 DOI: 10.1016/J.Virusres.2012.05.011 |
0.366 |
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| 2012 |
Musumeci F, Schenone S, Brullo C, Botta M. An update on dual Src/Abl inhibitors. Future Medicinal Chemistry. 4: 799-822. PMID 22530642 DOI: 10.4155/Fmc.12.29 |
0.389 |
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| 2012 |
Tintori C, Demeulemeester J, Franchi L, Massa S, Debyser Z, Christ F, Botta M. Discovery of small molecule HIV-1 integrase dimerization inhibitors. Bioorganic & Medicinal Chemistry Letters. 22: 3109-14. PMID 22483582 DOI: 10.1016/J.Bmcl.2012.03.064 |
0.382 |
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| 2012 |
Radi M, Pagano M, Franchi L, Castagnolo D, Schenone S, Casaluce G, Zamperini C, Dreassi E, Maga G, Samuele A, Gonzalo E, Clotet B, Esté JA, Botta M. Synthesis, biological activity, and ADME properties of novel S-DABOs/N-DABOs as HIV reverse transcriptase inhibitors. Chemmedchem. 7: 883-96. PMID 22419605 DOI: 10.1002/Cmdc.201200056 |
0.698 |
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| 2012 |
Demeulemeester J, Tintori C, Botta M, Debyser Z, Christ F. Development of an AlphaScreen-based HIV-1 integrase dimerization assay for discovery of novel allosteric inhibitors. Journal of Biomolecular Screening. 17: 618-28. PMID 22337657 DOI: 10.1177/1087057111436343 |
0.375 |
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| 2012 |
Cozzi M, Giorgi F, Marcelli E, Pentimalli F, Forte IM, Schenone S, D'Urso V, De Falco G, Botta M, Giordano A, Indovina P. Antitumor activity of new pyrazolo[3,4-d]pyrimidine SRC kinase inhibitors in Burkitt lymphoma cell lines and its enhancement by WEE1 inhibition. Cell Cycle (Georgetown, Tex.). 11: 1029-39. PMID 22333592 DOI: 10.4161/Cc.11.5.19519 |
0.358 |
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| 2012 |
Radi M, Falchi F, Garbelli A, Samuele A, Bernardo V, Paolucci S, Baldanti F, Schenone S, Manetti F, Maga G, Botta M. Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: towards the next generation HIV-1 inhibitors. Bioorganic & Medicinal Chemistry Letters. 22: 2094-8. PMID 22300661 DOI: 10.1016/J.Bmcl.2011.12.135 |
0.348 |
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| 2012 |
Crucitti GC, Botta M, Di Santo R. Will integrase inhibitors be used as microbicides? Current Hiv Research. 10: 36-41. PMID 22264044 DOI: 10.2174/157016212799304706 |
0.316 |
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| 2012 |
Furlan A, Colombo F, Kover A, Issaly N, Tintori C, Angeli L, Leroux V, Letard S, Amat M, Asses Y, Maigret B, Dubreuil P, Botta M, Dono R, Bosch J, et al. Identification of new aminoacid amides containing the imidazo[2,1-b]benzothiazol-2-ylphenyl moiety as inhibitors of tumorigenesis by oncogenic Met signaling. European Journal of Medicinal Chemistry. 47: 239-54. PMID 22138308 DOI: 10.1016/J.Ejmech.2011.10.051 |
0.402 |
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| 2012 |
Akselsen OW, Odlo K, Cheng JJ, Maccari G, Botta M, Hansen TV. Synthesis, biological evaluation and molecular modeling of 1,2,3-triazole analogs of combretastatin A-1. Bioorganic & Medicinal Chemistry. 20: 234-42. PMID 22137934 DOI: 10.1016/J.Bmc.2011.11.010 |
0.396 |
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| 2012 |
Maga G, Garbelli A, Radi M, Falchi F, Samuele A, Paolucci S, Baldanti F, Manetti F, Beermann S, Dietrich U, Botta M. Next generation of antiretroviral agents targeting the RNA binding site of the HIV-1 cellular cofactor DDX3: an innovative therapeutic approach Retrovirology. 9. DOI: 10.1186/1742-4690-9-S1-P5 |
0.371 |
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| 2012 |
Castagnolo D, Pagano M, Bernardini M, Botta M. Studies on the acylation of 4-(2-aminoethylthio)-7-nitrobenzofurazan: the role of bases in promoting the formation of fluorescent S-acyl derivatives through S–N Smiles rearrangement Tetrahedron Letters. 53: 5008-5011. DOI: 10.1016/J.Tetlet.2012.07.033 |
0.635 |
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| 2011 |
Arioli F, Borrelli S, Colombo F, Falchi F, Filippi I, Crespan E, Naldini A, Scalia G, Silvani A, Maga G, Carraro F, Botta M, Passarella D. N-[2-methyl-5-(triazol-1-yl)phenyl]pyrimidin-2-amine as a Scaffold for the synthesis of inhibitors of Bcr-Abl Chemmedchem. 6: 2009-2018. PMID 21990039 DOI: 10.1002/Cmdc.201100304 |
0.433 |
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| 2011 |
Corradi V, Mancini M, Santucci MA, Carlomagno T, Sanfelice D, Mori M, Vignaroli G, Falchi F, Manetti F, Radi M, Botta M. Computational techniques are valuable tools for the discovery of protein-protein interaction inhibitors: The 14-3-3σ case Bioorganic and Medicinal Chemistry Letters. 21: 6867-6871. PMID 21962576 DOI: 10.1016/J.Bmcl.2011.09.011 |
0.325 |
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| 2011 |
Mori M, Manetti F, Botta M. Targeting protein-protein and protein-nucleic acid interactions for anti-HIV therapy. Current Pharmaceutical Design. 17: 3713-28. PMID 21875413 DOI: 10.2174/138161211798220972 |
0.303 |
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| 2011 |
Radi M, Brullo C, Crespan E, Tintori C, Musumeci F, Biava M, Schenone S, Dreassi E, Zamperini C, Maga G, Pagano D, Angelucci A, Bologna M, Botta M. Identification of potent c-Src inhibitors strongly affecting the proliferation of human neuroblastoma cells. Bioorganic & Medicinal Chemistry Letters. 21: 5928-33. PMID 21856155 DOI: 10.1016/J.Bmcl.2011.07.079 |
0.386 |
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| 2011 |
Maccari G, Jaeger T, Moraca F, Biava M, Flohé L, Botta M. A fast virtual screening approach to identify structurally diverse inhibitors of trypanothione reductase. Bioorganic & Medicinal Chemistry Letters. 21: 5255-8. PMID 21807515 DOI: 10.1016/J.Bmcl.2011.07.036 |
0.372 |
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| 2011 |
Maga G, Falchi F, Radi M, Botta L, Casaluce G, Bernardini M, Irannejad H, Manetti F, Garbelli A, Samuele A, Zanoli S, Esté JA, Gonzalez E, Zucca E, Paolucci S, ... ... Botta M, et al. Toward the discovery of novel anti-HIV drugs. Second-generation inhibitors of the cellular ATPase DDX3 with improved anti-HIV activity: synthesis, structure-activity relationship analysis, cytotoxicity studies, and target validation. Chemmedchem. 6: 1371-89. PMID 21698775 DOI: 10.1002/Cmdc.201100166 |
0.407 |
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| 2011 |
Castagnolo D, Schenone S, Botta M. Guanylated diamines, triamines, and polyamines: chemistry and biological properties. Chemical Reviews. 111: 5247-300. PMID 21657224 DOI: 10.1021/Cr100423X |
0.694 |
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| 2011 |
Schenone S, Brullo C, Musumeci F, Biava M, Falchi F, Botta M. Fyn kinase in brain diseases and cancer: the search for inhibitors. Current Medicinal Chemistry. 18: 2921-42. PMID 21651487 DOI: 10.2174/092986711796150531 |
0.332 |
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| 2011 |
Romeo G, Materia L, Modica MN, Pittalà V, Salerno L, Siracusa MA, Manetti F, Botta M, Minneman KP. Novel 4-phenylpiperidine-2,6-dione derivatives. Ligands for α₁-adrenoceptor subtypes. European Journal of Medicinal Chemistry. 46: 2676-90. PMID 21514979 DOI: 10.1016/J.Ejmech.2011.03.054 |
0.31 |
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| 2011 |
Radi M, Dreassi E, Brullo C, Crespan E, Tintori C, Bernardo V, Valoti M, Zamperini C, Daigl H, Musumeci F, Carraro F, Naldini A, Filippi I, Maga G, Schenone S, ... Botta M, et al. Design, synthesis, biological activity, and ADME properties of pyrazolo[3,4-d]pyrimidines active in hypoxic human leukemia cells: a lead optimization study. Journal of Medicinal Chemistry. 54: 2610-26. PMID 21443205 DOI: 10.1021/Jm1012819 |
0.424 |
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| 2011 |
Tuccinardi T, Zizzari AT, Brullo C, Daniele S, Musumeci F, Schenone S, Trincavelli ML, Martini C, Martinelli A, Giorgi G, Botta M. Substituted pyrazolo[3,4-b]pyridines as human A1 adenosine antagonists: developments in understanding the receptor stereoselectivity. Organic & Biomolecular Chemistry. 9: 4448-55. PMID 21390354 DOI: 10.1039/C0Ob01064B |
0.349 |
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| 2011 |
Biava M, Porretta GC, Poce G, Battilocchio C, Alfonso S, de Logu A, Manetti F, Botta M. Developing pyrrole-derived antimycobacterial agents: a rational lead optimization approach. Chemmedchem. 6: 593-9. PMID 21341373 DOI: 10.1002/Cmdc.201000526 |
0.376 |
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| 2011 |
Rinaldi M, Tintori C, Franchi L, Vignaroli G, Innitzer A, Massa S, Esté JA, Gonzalo E, Christ F, Debyser Z, Botta M. A versatile and practical synthesis toward the development of novel HIV-1 integrase inhibitors. Chemmedchem. 6: 343-52. PMID 21246739 DOI: 10.1002/Cmdc.201000510 |
0.433 |
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| 2011 |
Schenone S, Tintori C, Botta M. Using insights into Pim1 structure to design new anticancer drugs. Current Pharmaceutical Design. 16: 3964-78. PMID 21158732 DOI: 10.2174/138161210794454996 |
0.37 |
|
| 2011 |
Mancini M, Corradi V, Petta S, Barbieri E, Manetti F, Botta M, Santucci MA. A new nonpeptidic inhibitor of 14-3-3 induces apoptotic cell death in chronic myeloid leukemia sensitive or resistant to imatinib. The Journal of Pharmacology and Experimental Therapeutics. 336: 596-604. PMID 21041536 DOI: 10.1124/Jpet.110.172536 |
0.323 |
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| 2011 |
Castiglioni E, Di Fabio R, Togninelli A, Brough S, Brown F, Dal Cin M, Gianotti M, Marchioro C, Merlo G, Spinosa R, Wigglesworth MJ, Botta M. Towards the discovery of new hypnotic agents: synthesis and preliminary pharmacological evaluation of a novel class of dibenzo[a,d]cycloheptene derivatives. Chemmedchem. 5: 1843-6. PMID 20922744 DOI: 10.1002/Cmdc.201000280 |
0.371 |
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| 2011 |
Schenone S, Bruno O, Radi M, Botta M. New insights into small-molecule inhibitors of Bcr-Abl. Medicinal Research Reviews. 31: 1-41. PMID 19714578 DOI: 10.1002/Med.20175 |
0.356 |
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| 2011 |
Indovina P, Giorgi F, Rizzo V, Khadang B, Schenone S, Mattioli E, Tomei V, Dimarzo D, Forte IM, D'Urso V, Botta M, Giordano A, Pentimalli F. Abstract LB-227: New SRC inhibitors induce p27-mediated apoptosis in mesothelioma cell lines Cancer Research. 71. DOI: 10.1158/1538-7445.Am2011-Lb-227 |
0.315 |
|
| 2011 |
Botta M, Radi M, Casaluce G. A Domino Microwave-Assisted Protocol for the Synthesis of 2,6-Disubstituted Pyrimidinones Synlett. 2011: 1997-2000. DOI: 10.1055/S-0030-1261174 |
0.306 |
|
| 2010 |
Castagnolo D, Contemori L, Maccari G, Avramova SI, Neri A, Sgaragli G, Botta M. From taxuspine x to structurally simplified taxanes with remarkable p-glycoprotein inhibitory activity. Acs Medicinal Chemistry Letters. 1: 416-21. PMID 24900226 DOI: 10.1021/Ml100118K |
0.638 |
|
| 2010 |
Maga G, Radi M, Gerard MA, Botta M, Ennifar E. HIV-1 RT Inhibitors with a Novel Mechanism of Action: NNRTIs that Compete with the Nucleotide Substrate. Viruses. 2: 880-99. PMID 21994659 DOI: 10.3390/V2040880 |
0.39 |
|
| 2010 |
Mori M, Manetti F, Botta M. Predicting the binding mode of known NCp7 inhibitors to facilitate the design of novel modulators. Journal of Chemical Information and Modeling. 51: 446-54. PMID 21171587 DOI: 10.1021/Ci100393M |
0.345 |
|
| 2010 |
Dreassi E, Zizzari AT, Mori M, Filippi I, Belfiore A, Naldini A, Carraro F, Santucci A, Schenone S, Botta M. 2-Hydroxypropyl-β-cyclodextrin strongly improves water solubility and anti-proliferative activity of pyrazolo[3,4-d]pyrimidines Src-Abl dual inhibitors. European Journal of Medicinal Chemistry. 45: 5958-64. PMID 20970221 DOI: 10.1016/J.Ejmech.2010.09.062 |
0.331 |
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| 2010 |
Biava M, Porretta GC, Poce G, Battilocchio C, Alfonso S, De Logu A, Serra N, Manetti F, Botta M. Identification of a novel pyrrole derivative endowed with antimycobacterial activity and protection index comparable to that of the current antitubercular drugs streptomycin and rifampin. Bioorganic & Medicinal Chemistry. 18: 8076-84. PMID 20934344 DOI: 10.1016/J.Bmc.2010.09.006 |
0.37 |
|
| 2010 |
Corradi V, Mancini M, Manetti F, Petta S, Santucci MA, Botta M. Identification of the first non-peptidic small molecule inhibitor of the c-Abl/14-3-3 protein-protein interactions able to drive sensitive and Imatinib-resistant leukemia cells to apoptosis. Bioorganic & Medicinal Chemistry Letters. 20: 6133-7. PMID 20832303 DOI: 10.1016/J.Bmcl.2010.08.019 |
0.332 |
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| 2010 |
Schenone S, Brullo C, Musumeci F, Botta M. Novel dual Src/Abl inhibitors for hematologic and solid malignancies. Expert Opinion On Investigational Drugs. 19: 931-45. PMID 20557276 DOI: 10.1517/13543784.2010.499898 |
0.305 |
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| 2010 |
Radi M, Crespan E, Falchi F, Bernardo V, Zanoli S, Manetti F, Schenone S, Maga G, Botta M. Design and synthesis of thiadiazoles and thiazoles targeting the Bcr-Abl T315I mutant: from docking false positives to ATP-noncompetitive inhibitors. Chemmedchem. 5: 1226-31. PMID 20509136 DOI: 10.1002/Cmdc.201000066 |
0.337 |
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| 2010 |
Crespan E, Radi M, Zanoli S, Schenone S, Botta M, Maga G. Dual Src and Abl inhibitors target wild type Abl and the AblT315I Imatinib-resistant mutant with different mechanisms. Bioorganic & Medicinal Chemistry. 18: 3999-4008. PMID 20451394 DOI: 10.1016/J.Bmc.2010.04.024 |
0.342 |
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| 2010 |
Radi M, Botta L, Casaluce G, Bernardini M, Botta M. Practical one-pot two-step protocol for the microwave-assisted synthesis of highly functionalized rhodanine derivatives. Journal of Combinatorial Chemistry. 12: 200-5. PMID 20028090 DOI: 10.1021/Cc9001789 |
0.344 |
|
| 2010 |
Biava M, Porretta GC, Poce G, Battilocchio C, Manetti F, Botta M, Forli S, Sautebin L, Rossi A, Pergola C, Ghelardini C, Galeotti N, Makovec F, Giordani A, Anzellotti P, et al. Novel ester and acid derivatives of the 1,5-diarylpyrrole scaffold as anti-inflammatory and analgesic agents. Synthesis and in vitro and in vivo biological evaluation. Journal of Medicinal Chemistry. 53: 723-33. PMID 19957931 DOI: 10.1021/Jm901269Y |
0.394 |
|
| 2010 |
Forli S, Manetti F, Altmann KH, Botta M. Evaluation of novel epothilone analogues by means of a common pharmacophore and a QSAR pseudoreceptor model for taxanes and epothilones. Chemmedchem. 5: 35-40. PMID 19904799 DOI: 10.1002/Cmdc.200900303 |
0.313 |
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| 2010 |
Maga G, Falchi F, Garbelli A, Radi M, Paolucci S, Baldanti F, Botta M. Inhibitors of human immunodeficiency virus-1 replication targeting the human DEAD-box polypeptide 3 (DDX3) RNA helicase Retrovirology. 7. DOI: 10.1186/1742-4690-7-S1-O16 |
0.417 |
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| 2010 |
Botta M, Franchi L, Rinaldi M, Vignaroli G, Innitzer A, Radi M. Arylation of 2-Furyl 4-Fluorophenyl Ketone: An Extension of Heck Chemistry towards Novel Integrase Inhibitors Synthesis. 2010: 3927-3933. DOI: 10.1055/S-0030-1258247 |
0.396 |
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| 2010 |
Castagnolo D, Contemori L, MacCari G, Avramova SI, Neri A, Sgaragli G, Botta M. From taxuspine X to structurally simplified taxanes with remarkable P-glycoprotein inhibitory activity Acs Medicinal Chemistry Letters. 1: 416-421. DOI: 10.1021/ml100118k |
0.589 |
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| 2010 |
Castagnolo D, Botta M. Iron-Catalyzed Cross-Coupling between 1-Bromoalkynes and Grignard-Derived Organocuprate Reagents European Journal of Organic Chemistry. 2010: 3224-3228. DOI: 10.1002/Ejoc.201000393 |
0.646 |
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| 2010 |
Forli S, Manetti F, Altmann K, Botta M. Cover Picture: Evaluation of Novel Epothilone Analogues by means of a Common Pharmacophore and a QSAR Pseudoreceptor Model for Taxanes and Epothilones (ChemMedChem 1/2010) Chemmedchem. 5: 1-1. DOI: 10.1002/Cmdc.200990062 |
0.311 |
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| 2009 |
Caporuscio F, Tafi A, González E, Manetti F, Esté JA, Botta M. A dynamic target-based pharmacophoric model mapping the CD4 binding site on HIV-1 gp120 to identify new inhibitors of gp120-CD4 protein-protein interactions. Bioorganic & Medicinal Chemistry Letters. 19: 6087-91. PMID 19783140 DOI: 10.1016/J.Bmcl.2009.09.029 |
0.311 |
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| 2009 |
Manetti F, Castagnolo D, Raffi F, Zizzari AT, Rajamäki S, D'Arezzo S, Visca P, Cona A, Fracasso ME, Doria D, Posteraro B, Sanguinetti M, Fadda G, Botta M. Synthesis of new linear guanidines and macrocyclic amidinourea derivatives endowed with high antifungal activity against Candida spp. and Aspergillus spp. Journal of Medicinal Chemistry. 52: 7376-9. PMID 19650630 DOI: 10.1021/Jm900760K |
0.676 |
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| 2009 |
Biava M, Porretta GC, Poce G, De Logu A, Meleddu R, De Rossi E, Manetti F, Botta M. 1,5-Diaryl-2-ethyl pyrrole derivatives as antimycobacterial agents: design, synthesis, and microbiological evaluation. European Journal of Medicinal Chemistry. 44: 4734-8. PMID 19595488 DOI: 10.1016/J.Ejmech.2009.06.005 |
0.423 |
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| 2009 |
Manetti F, Cona A, Angeli L, Mugnaini C, Raffi F, Capone C, Dreassi E, Zizzari AT, Tisi A, Federico R, Botta M. Synthesis and biological evaluation of guanidino compounds endowed with subnanomolar affinity as competitive inhibitors of maize polyamine oxidase Journal of Medicinal Chemistry. 52: 4774-4785. PMID 19591488 DOI: 10.1021/Jm900371Z |
0.438 |
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| 2009 |
Radi M, Schenone S, Botta M. Recent highlights in the synthesis of highly functionalized pyrimidines. Organic & Biomolecular Chemistry. 7: 2841-7. PMID 19582291 DOI: 10.1039/B906445A |
0.382 |
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| 2009 |
Castagnolo D, Manetti F, Radi M, Bechi B, Pagano M, De Logu A, Meleddu R, Saddi M, Botta M. Synthesis, biological evaluation, and SAR study of novel pyrazole analogues as inhibitors of Mycobacterium tuberculosis: part 2. Synthesis of rigid pyrazolones. Bioorganic & Medicinal Chemistry. 17: 5716-21. PMID 19581099 DOI: 10.1016/J.Bmc.2009.05.058 |
0.711 |
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| 2009 |
Castagnolo D, Botta L, Botta M. Stereoselective protecting group free synthesis of D,L-gulose ethyl glycoside via multicomponent enyne cross metathesis--hetero Diels-Alder reaction. Carbohydrate Research. 344: 1285-8. PMID 19501816 DOI: 10.1016/J.Carres.2009.05.007 |
0.653 |
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| 2009 |
Rajamaki S, Innitzer A, Falciani C, Tintori C, Christ F, Witvrouw M, Debyser Z, Massa S, Botta M. Exploration of novel thiobarbituric acid-, rhodanine- and thiohydantoin-based HIV-1 integrase inhibitors. Bioorganic & Medicinal Chemistry Letters. 19: 3615-8. PMID 19447621 DOI: 10.1016/J.Bmcl.2009.04.132 |
0.39 |
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| 2009 |
Dreassi E, Zizzari AT, Falchi F, Schenone S, Santucci A, Maga G, Botta M. Determination of permeability and lipophilicity of pyrazolo-pyrimidine tyrosine kinase inhibitors and correlation with biological data. European Journal of Medicinal Chemistry. 44: 3712-7. PMID 19410338 DOI: 10.1016/J.Ejmech.2009.03.039 |
0.386 |
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| 2009 |
Castagnolo D, Botta L, Botta M. Alkyne-enol ether cross-metathesis in the presence of CuSO(4): direct formation of 3-substituted crotonaldehydes in aqueous medium. The Journal of Organic Chemistry. 74: 3172-4. PMID 19354326 DOI: 10.1021/Jo900205X |
0.65 |
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| 2009 |
Falchi F, Manetti F, Carraro F, Naldini A, Maga G, Crespan E, Schenone S, Bruno O, Brullo C, Botta M. 3D QSAR models built on structure-based alignments of Abl tyrosine kinase inhibitors. Chemmedchem. 4: 976-87. PMID 19326384 DOI: 10.1002/Cmdc.200800441 |
0.405 |
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| 2009 |
Castagnolo D, Radi M, Dessì F, Manetti F, Saddi M, Meleddu R, De Logu A, Botta M. Synthesis and biological evaluation of new enantiomerically pure azole derivatives as inhibitors of Mycobacterium tuberculosis. Bioorganic & Medicinal Chemistry Letters. 19: 2203-5. PMID 19299129 DOI: 10.1016/J.Bmcl.2009.02.101 |
0.705 |
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| 2009 |
Olla S, Manetti F, Crespan E, Maga G, Angelucci A, Schenone S, Bologna M, Botta M. Indolyl-pyrrolone as a new scaffold for Pim1 inhibitors. Bioorganic & Medicinal Chemistry Letters. 19: 1512-6. PMID 19179076 DOI: 10.1016/J.Bmcl.2009.01.005 |
0.405 |
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| 2009 |
Radi M, Maga G, Alongi M, Angeli L, Samuele A, Zanoli S, Bellucci L, Tafi A, Casaluce G, Giorgi G, Armand-Ugon M, Gonzalez E, Esté JA, Baltzinger M, Bec G, ... ... Botta M, et al. Discovery of chiral cyclopropyl dihydro-alkylthio-benzyl-oxopyrimidine (S-DABO) derivatives as potent HIV-1 reverse transcriptase inhibitors with high activity against clinically relevant mutants. Journal of Medicinal Chemistry. 52: 840-51. PMID 19140683 DOI: 10.1021/Jm801330N |
0.411 |
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| 2009 |
Schenone S, Brullo C, Botta M. Small molecules ATP-competitive inhibitors of FLT3: a chemical overview. Current Medicinal Chemistry. 15: 3113-32. PMID 19075657 DOI: 10.2174/092986708786848613 |
0.366 |
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| 2009 |
Cincinelli R, Cassinelli G, Dallavalle S, Lanzi C, Merlini L, Botta M, Tuccinardi T, Martinelli A, Penco S, Zunino F. Synthesis, modeling, and RET protein kinase inhibitory activity of 3- and 4-substituted beta-carbolin-1-ones. Journal of Medicinal Chemistry. 51: 7777-87. PMID 19053769 DOI: 10.1021/Jm8007823 |
0.391 |
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| 2009 |
Santucci MA, Corradi V, Mancini M, Manetti F, Radi M, Schenone S, Botta M. C6-unsubstituted pyrazolo[3,4-d]pyrimidines are dual Src/Abl inhibitors effective against imatinib mesylate resistant chronic myeloid leukemia cell lines. Chemmedchem. 4: 118-26. PMID 19039816 DOI: 10.1002/Cmdc.200800320 |
0.378 |
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| 2009 |
Tintori C, Corradi V, Magnani M, Manetti F, Botta M. Targets looking for drugs: a multistep computational protocol for the development of structure-based pharmacophores and their applications for hit discovery. Journal of Chemical Information and Modeling. 48: 2166-79. PMID 18942779 DOI: 10.1021/Ci800105P |
0.329 |
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| 2009 |
Schenone S, Bruno O, Radi M, Botta M. 4-Amino-Substituted Pyrazolo[3,4-d]Pyrimidines: Synthesis and Biological Properties Mini-Reviews in Organic Chemistry. 6: 220-233. DOI: 10.2174/157019309788922739 |
0.33 |
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| 2009 |
Botta M, Castagnolo D, Pagano M, Bernardini M. Domino Alkylation-Cyclization Reaction of Propargyl Bromides with Thioureas/Thiopyrimidinones: A New Facile Synthesis of 2-Aminothiazoles and 5H-Thiazolo[3,2-a]pyrimidin-5-ones Synlett. 2009: 2093-2096. DOI: 10.1055/S-0029-1217700 |
0.668 |
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| 2009 |
Radi M, Bernardo V, Bechi B, Castagnolo D, Pagano M, Botta M. Microwave-assisted organocatalytic multicomponent Knoevenagel/hetero Diels–Alder reaction for the synthesis of 2,3-dihydropyran[2,3-c]pyrazoles Tetrahedron Letters. 50: 6572-6575. DOI: 10.1016/J.Tetlet.2009.09.047 |
0.662 |
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| 2009 |
Castagnolo D, Botta L, Botta M. One-pot multicomponent synthesis of 2,3-dihydropyrans: new access to furanose–pyranose 1,3-C–C-linked-disaccharides Tetrahedron Letters. 50: 1526-1528. DOI: 10.1016/J.Tetlet.2009.01.047 |
0.664 |
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| 2009 |
Castagnolo D, Raffi F, Giorgi G, Botta M. Macrocyclization of Di-Boc-guanidino-alkylamines Related to Guazatine Components: Discovery and Synthesis of Innovative Macrocyclic Amidinoureas European Journal of Organic Chemistry. 2009: 334-337. DOI: 10.1002/Ejoc.200801109 |
0.674 |
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| 2008 |
Baraldi PG, Preti D, Tabrizi MA, Romagnoli R, Saponaro G, Baraldi S, Botta M, Bernardini C, Tafi A, Tuccinardi T, Martinelli A, Varani K, Borea PA. Structure-activity relationship studies of a new series of imidazo[2,1-f]purinones as potent and selective A(3) adenosine receptor antagonists. Bioorganic & Medicinal Chemistry. 16: 10281-94. PMID 19006671 DOI: 10.1016/J.Bmc.2008.10.049 |
0.369 |
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| 2008 |
Radi M, Angeli L, Franchi L, Contemori L, Maga G, Samuele A, Zanoli S, Armand-Ugon M, Gonzalez E, Llano A, Esté JA, Botta M. Towards novel S-DABOC inhibitors: synthesis, biological investigation, and molecular modeling studies. Bioorganic & Medicinal Chemistry Letters. 18: 5777-80. PMID 18842407 DOI: 10.1016/J.Bmcl.2008.09.070 |
0.401 |
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| 2008 |
Maga G, Falchi F, Garbelli A, Belfiore A, Witvrouw M, Manetti F, Botta M. Pharmacophore modeling and molecular docking led to the discovery of inhibitors of human immunodeficiency virus-1 replication targeting the human cellular aspartic acid-glutamic acid-alanine-aspartic acid box polypeptide 3 Journal of Medicinal Chemistry. 51: 6635-6638. PMID 18834110 DOI: 10.1021/Jm8008844 |
0.347 |
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| 2008 |
Castagnolo D, De Logu A, Radi M, Bechi B, Manetti F, Magnani M, Supino S, Meleddu R, Chisu L, Botta M. Synthesis, biological evaluation and SAR study of novel pyrazole analogues as inhibitors of Mycobacterium tuberculosis. Bioorganic & Medicinal Chemistry. 16: 8587-91. PMID 18752962 DOI: 10.1016/J.Bmc.2008.08.016 |
0.705 |
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| 2008 |
Biava M, Porretta GC, Poce G, Supino S, Manetti F, Forli S, Botta M, Sautebin L, Rossi A, Pergola C, Ghelardini C, Norcini M, Makovec F, Giordani A, Anzellotti P, et al. Synthesis, in vitro, and in vivo biological evaluation and molecular docking simulations of chiral alcohol and ether derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents. Bioorganic & Medicinal Chemistry. 16: 8072-81. PMID 18752957 DOI: 10.1016/J.Bmc.2008.07.058 |
0.367 |
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| 2008 |
Tintori C, Magnani M, Schenone S, Botta M. Docking, 3D-QSAR studies and in silico ADME prediction on c-Src tyrosine kinase inhibitors. European Journal of Medicinal Chemistry. 44: 990-1000. PMID 18722033 DOI: 10.1016/J.Ejmech.2008.07.002 |
0.376 |
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| 2008 |
Pasquini S, Mugnaini C, Tintori C, Botta M, Trejos A, Arvela RK, Larhed M, Witvrouw M, Michiels M, Christ F, Debyser Z, Corelli F. Investigations on the 4-quinolone-3-carboxylic acid motif. 1. Synthesis and structure-activity relationship of a class of human immunodeficiency virus type 1 integrase inhibitors Journal of Medicinal Chemistry. 51: 5125-5129. PMID 18665580 DOI: 10.1021/Jm8003784 |
0.405 |
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| 2008 |
Manetti F, Falchi F, Crespan E, Schenone S, Maga G, Botta M. N-(thiazol-2-yl)-2-thiophene carboxamide derivatives as Abl inhibitors identified by a pharmacophore-based database screening of commercially available compounds. Bioorganic & Medicinal Chemistry Letters. 18: 4328-31. PMID 18621522 DOI: 10.1016/J.Bmcl.2008.06.082 |
0.398 |
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| 2008 |
Anzini M, Rovini M, Cappelli A, Vomero S, Manetti F, Botta M, Sautebin L, Rossi A, Pergola C, Ghelardini C, Norcini M, Giordani A, Makovec F, Anzellotti P, Patrignani P, et al. Synthesis, biological evaluation, and enzyme docking simulations of 1,5-diarylpyrrole-3-alkoxyethyl ethers as selective cyclooxygenase-2 inhibitors endowed with anti-inflammatory and antinociceptive activity. Journal of Medicinal Chemistry. 51: 4476-81. PMID 18598017 DOI: 10.1021/Jm800084S |
0.403 |
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| 2008 |
La Regina G, D'Auria FD, Tafi A, Piscitelli F, Olla S, Caporuscio F, Nencioni L, Cirilli R, La Torre F, De Melo NR, Kelly SL, Lamb DC, Artico M, Botta M, Palamara AT, et al. 1-[(3-Aryloxy-3-aryl)propyl]-1H-imidazoles, new imidazoles with potent activity against Candida albicans and dermatophytes. Synthesis, structure-activity relationship, and molecular modeling studies. Journal of Medicinal Chemistry. 51: 3841-55. PMID 18529046 DOI: 10.1021/Jm800009R |
0.417 |
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| 2008 |
Biava M, Porretta GC, Poce G, De Logu A, Saddi M, Meleddu R, Manetti F, De Rossi E, Botta M. 1,5-Diphenylpyrrole derivatives as antimycobacterial agents. Probing the influence on antimycobacterial activity of lipophilic substituents at the phenyl rings. Journal of Medicinal Chemistry. 51: 3644-8. PMID 18494459 DOI: 10.1021/Jm701560P |
0.388 |
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| 2008 |
Tassoni E, Giannessi F, Brunetti T, Pessotto P, Renzulli M, Travagli M, Rajamäki S, Prati S, Dottori S, Corelli F, Cabri W, Carminati P, Botta M. Novel substituted aminoalkylguanidines as potential antihyperglycemic and food intake-reducing agents. Journal of Medicinal Chemistry. 51: 3073-6. PMID 18465847 DOI: 10.1021/Jm8001636 |
0.312 |
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| 2008 |
Schenone S, Brullo C, Bruno O, Bondavalli F, Mosti L, Maga G, Crespan E, Carraro F, Manetti F, Tintori C, Botta M. Synthesis, biological evaluation and docking studies of 4-amino substituted 1H-pyrazolo[3,4-d]pyrimidines. European Journal of Medicinal Chemistry. 43: 2665-76. PMID 18342402 DOI: 10.1016/J.Ejmech.2008.01.034 |
0.434 |
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| 2008 |
Tuccinardi T, Schenone S, Bondavalli F, Brullo C, Bruno O, Mosti L, Zizzari AT, Tintori C, Manetti F, Ciampi O, Trincavelli ML, Martini C, Martinelli A, Botta M. Substituted pyrazolo[3,4-b]pyridines as potent A1 adenosine antagonists: synthesis, biological evaluation, and development of an A1 bovine receptor model. Chemmedchem. 3: 898-913. PMID 18338422 DOI: 10.1002/Cmdc.200700355 |
0.354 |
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| 2008 |
Grohmann D, Corradi V, Elbasyouny M, Baude A, Horenkamp F, Laufer SD, Manetti F, Botta M, Restle T. Small molecule inhibitors targeting HIV-1 reverse transcriptase dimerization. Chembiochem : a European Journal of Chemical Biology. 9: 916-22. PMID 18318036 DOI: 10.1002/Cbic.200700669 |
0.409 |
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| 2008 |
Silvestri R, Cascio MG, La Regina G, Piscitelli F, Lavecchia A, Brizzi A, Pasquini S, Botta M, Novellino E, Di Marzo V, Corelli F. Synthesis, cannabinoid receptor affinity, and molecular modeling studies of substituted 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides. Journal of Medicinal Chemistry. 51: 1560-76. PMID 18293908 DOI: 10.1021/Jm070566Z |
0.333 |
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| 2008 |
Manetti F, Brullo C, Magnani M, Mosci F, Chelli B, Crespan E, Schenone S, Naldini A, Bruno O, Trincavelli ML, Maga G, Carraro F, Martini C, Bondavalli F, Botta M. Structure-based optimization of pyrazolo[3,4-d]pyrimidines as Abl inhibitors and antiproliferative agents toward human leukemia cell lines. Journal of Medicinal Chemistry. 51: 1252-9. PMID 18257513 DOI: 10.1021/Jm701240C |
0.357 |
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| 2008 |
Avramova SI, Galletti E, Renzulli ML, Giorgi G, Sgaragli G, Alderighi D, Ghiron C, Corelli F, Radi M, Botta M. Synthesis of an original oxygenated taxuspine X analogue: A versatile "non-natural" natural product with remarkable P-gp modulating activity Chemmedchem. 3: 745-748. PMID 18232049 DOI: 10.1002/Cmdc.200700337 |
0.362 |
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| 2008 |
Spreafico A, Schenone S, Serchi T, Orlandini M, Angelucci A, Magrini D, Bernardini G, Collodel G, Di Stefano A, Tintori C, Bologna M, Manetti F, Botta M, Santucci A. Antiproliferative and proapoptotic activities of new pyrazolo[3,4-d]pyrimidine derivative Src kinase inhibitors in human osteosarcoma cells. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 1560-71. PMID 18171692 DOI: 10.1096/Fj.07-9873Com |
0.342 |
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| 2008 |
Radi M, Falciani C, Contemori L, Petricci E, Maga G, Samuele A, Zanoli S, Terrazas M, Castria M, Togninelli A, Esté JA, Clotet-Codina I, Armand-Ugón M, Botta M. A multidisciplinary approach for the identification of novel HIV-1 non-nucleoside reverse transcriptase inhibitors: S-DABOCs and DAVPs. Chemmedchem. 3: 573-93. PMID 18081133 DOI: 10.1002/Cmdc.200700198 |
0.366 |
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| 2008 |
Morisi R, Celano M, Tosi E, Schenone S, Navarra M, Ferretti E, Costante G, Durante C, Botta G, D'Agostino M, Brullo C, Filetti S, Botta M, Russo D. Growth inhibition of medullary thyroid carcinoma cells by pyrazolo-pyrimidine derivates. Journal of Endocrinological Investigation. 30: RC31-4. PMID 18075281 DOI: 10.1007/Bf03349220 |
0.307 |
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| 2008 |
Schenone S, Manetti F, Botta M. Synthetic SRC-kinase domain inhibitors and their structural requirements. Anti-Cancer Agents in Medicinal Chemistry. 7: 660-80. PMID 18045061 DOI: 10.2174/187152007784111269 |
0.33 |
|
| 2008 |
Galletti E, Magnani M, Renzulli ML, Botta M. Paclitaxel and docetaxel resistance: molecular mechanisms and development of new generation taxanes. Chemmedchem. 2: 920-42. PMID 17530726 DOI: 10.1002/Cmdc.200600308 |
0.335 |
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| 2008 |
Manetti F, Pucci A, Magnani M, Locatelli GA, Brullo C, Naldini A, Schenone S, Maga G, Carraro F, Botta M. Inhibition of Bcr-Abl phosphorylation and induction of apoptosis by pyrazolo[3,4-d]pyrimidines in human leukemia cells. Chemmedchem. 2: 343-53. PMID 17295370 DOI: 10.1002/Cmdc.200600214 |
0.375 |
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| 2008 |
Radi M, Saletti S, Botta M. A one-pot, two-step microwave-assisted synthesis of highly functionalized benzoxazoles using solid-supported reagents (SSRs) Tetrahedron Letters. 49: 4464-4466. DOI: 10.1016/J.Tetlet.2008.05.059 |
0.355 |
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| 2007 |
Radi M, Crespan E, Botta G, Falchi F, Maga G, Manetti F, Corradi V, Mancini M, Santucci MA, Schenone S, Botta M. Discovery and SAR of 1,3,4-thiadiazole derivatives as potent Abl tyrosine kinase inhibitors and cytodifferentiating agents. Bioorganic & Medicinal Chemistry Letters. 18: 1207-11. PMID 18078752 DOI: 10.1016/J.Bmcl.2007.11.112 |
0.387 |
|
| 2007 |
Mugnaini C, Alongi M, Togninelli A, Gevariya H, Brizzi A, Manetti F, Bernardini C, Angeli L, Tafi A, Bellucci L, Corelli F, Massa S, Maga G, Samuele A, Facchini M, ... ... Botta M, et al. Dihydro-alkylthio-benzyl-oxopyrimidines as inhibitors of reverse transcriptase: synthesis and rationalization of the biological data on both wild-type enzyme and relevant clinical mutants. Journal of Medicinal Chemistry. 50: 6580-95. PMID 18052319 DOI: 10.1021/Jm0708230 |
0.436 |
|
| 2007 |
Manetti F, Santucci A, Locatelli GA, Maga G, Spreafico A, Serchi T, Orlandini M, Bernardini G, Caradonna NP, Spallarossa A, Brullo C, Schenone S, Bruno O, Ranise A, Bondavalli F, ... ... Botta M, et al. Identification of a novel pyrazolo[3,4-d]pyrimidine able to inhibit cell proliferation of a human osteogenic sarcoma in vitro and in a xenograft model in mice. Journal of Medicinal Chemistry. 50: 5579-88. PMID 17929792 DOI: 10.1021/Jm061449R |
0.339 |
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| 2007 |
Biava M, Porretta GC, Poce G, Supino S, Forli S, Rovini M, Cappelli A, Manetti F, Botta M, Sautebin L, Rossi A, Pergola C, Ghelardini C, Vivoli E, Makovec F, et al. Cyclooxygenase-2 inhibitors. 1,5-diarylpyrrol-3-acetic esters with enhanced inhibitory activity toward cyclooxygenase-2 and improved cyclooxygenase-2/cyclooxygenase-1 selectivity. Journal of Medicinal Chemistry. 50: 5403-11. PMID 17915854 DOI: 10.1021/Jm0707525 |
0.446 |
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| 2007 |
Raiber EA, Wilkinson JA, Manetti F, Botta M, Deakin J, Gallagher J, Lyon M, Ducki SW. Novel heparin/heparan sulfate mimics as inhibitors of HGF/SF-induced MET activation. Bioorganic & Medicinal Chemistry Letters. 17: 6321-5. PMID 17870532 DOI: 10.1016/J.Bmcl.2007.08.074 |
0.335 |
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| 2007 |
Mugnaini C, Rajamaki S, Tintori C, Corelli F, Massa S, Witvrouw M, Debyser Z, Veljkovic V, Botta M. Toward novel HIV-1 integrase binding inhibitors: molecular modeling, synthesis, and biological studies. Bioorganic & Medicinal Chemistry Letters. 17: 5370-3. PMID 17716893 DOI: 10.1016/J.Bmcl.2007.08.005 |
0.41 |
|
| 2007 |
Schenone S, Manetti F, Botta M. SRC inhibitors and angiogenesis. Current Pharmaceutical Design. 13: 2118-28. PMID 17627544 DOI: 10.2174/138161207781039580 |
0.319 |
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| 2007 |
Radi M, Contemori L, Castagnolo D, Spinosa R, Esté JA, Massa S, Botta M. A versatile route to C-6 arylmethyl-functionalized S-DABO and related analogues. Organic Letters. 9: 3157-60. PMID 17625879 DOI: 10.1021/Ol071225I |
0.698 |
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| 2007 |
Tintori C, Manetti F, Veljkovic N, Perovic V, Vercammen J, Hayes S, Massa S, Witvrouw M, Debyser Z, Veljkovic V, Botta M. Novel virtual screening protocol based on the combined use of molecular modeling and electron-ion interaction potential techniques to design HIV-1 integrase inhibitors. Journal of Chemical Information and Modeling. 47: 1536-44. PMID 17608406 DOI: 10.1021/Ci700078N |
0.379 |
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| 2007 |
Schenone S, Manetti F, Botta M. Last findings on dual inhibitors of abl and SRC tyrosine-kinases. Mini Reviews in Medicinal Chemistry. 7: 191-201. PMID 17305593 DOI: 10.2174/138955707779802598 |
0.323 |
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| 2007 |
Tuccinardi T, Manetti F, Schenone S, Martinelli A, Botta M. Construction and validation of a RET TK catalytic domain by homology modeling. Journal of Chemical Information and Modeling. 47: 644-55. PMID 17295463 DOI: 10.1021/Ci6004383 |
0.359 |
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| 2007 |
Botta M, Armaroli S, Castagnolo D, Fontana G, Pera P, Bombardelli E. Synthesis and biological evaluation of new taxoids derived from 2-deacetoxytaxinine J. Bioorganic & Medicinal Chemistry Letters. 17: 1579-83. PMID 17254787 DOI: 10.1016/J.Bmcl.2006.12.101 |
0.668 |
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| 2007 |
Radi M, Petricci E, Corelli F, Botta M. Stereoselective Synthesis of N1-6-Methyluridine and Related 2-Substituted Analogues Heterocycles. 72: 79. DOI: 10.3987/Com-06-S(K)3 |
0.319 |
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| 2007 |
Botta M, Raffi F, Corelli F. Efficient Synthesis of Iminoctadine, a Potent Antifungal Agent and Polyamine Oxidase Inhibitor (PAO) Synthesis. 2007: 3013-3016. DOI: 10.1055/S-2007-983898 |
0.41 |
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| 2007 |
Galletti E, Avramova SI, Renzulli ML, Corelli F, Botta M. Stereoselective synthesis of advanced intermediates en route to Taxuspine U and X: a study of macrocyclization via ring closing metathesis to highly constrained twelve-membered rings Tetrahedron Letters. 48: 751-754. DOI: 10.1016/J.Tetlet.2006.11.167 |
0.33 |
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| 2007 |
Castagnolo D, Dessì F, Radi M, Botta M. Synthesis of enantiomerically pure α-[4-(1-substituted)-1,2,3-triazol-4-yl]-benzylacetamides via microwave-assisted click chemistry: towards new potential antimicrobial agents Tetrahedron: Asymmetry. 18: 1345-1350. DOI: 10.1016/J.Tetasy.2007.06.007 |
0.688 |
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| 2007 |
Renzulli ML, Rocheblave L, Avramova SI, Galletti E, Castagnolo D, Tafi A, Corelli F, Botta M. Studies towards the synthesis of the bicyclic 3,8-secotaxane diterpenoid system using a ring closing metathesis strategy Tetrahedron. 63: 497-509. DOI: 10.1016/J.Tet.2006.10.058 |
0.656 |
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| 2007 |
Castagnolo D, Giorgi G, Spinosa R, Corelli F, Botta M. Practical Syntheses of Enantiomerically PureN-Acetylbenzhydrylamines European Journal of Organic Chemistry. 2007: 3676-3686. DOI: 10.1002/Ejoc.200700193 |
0.688 |
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| 2006 |
Mugnaini C, Petricci E, Botta M, Corelli F, Mastromarino P, Giorgi G. Synthesis and biological evaluation of 4-alkylamino-6-(2-hydroxyethyl)-2-methylthiopyrimidines as new rubella virus inhibitors. European Journal of Medicinal Chemistry. 42: 256-62. PMID 17045364 DOI: 10.1016/J.Ejmech.2006.09.002 |
0.391 |
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| 2006 |
Semeraro T, Lossani A, Botta M, Ghiron C, Alvarez R, Manetti F, Mugnaini C, Valensin S, Focher F, Corelli F. Simplified analogues of immucillin-G retain potent human purine nucleoside phosphorylase inhibitory activity. Journal of Medicinal Chemistry. 49: 6037-45. PMID 17004717 DOI: 10.1021/Jm060547+ |
0.461 |
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| 2006 |
Manetti F, Magnani M, Castagnolo D, Passalacqua L, Botta M, Corelli F, Saddi M, Deidda D, De Logu A. Ligand-based virtual screening, parallel solution-phase and microwave-assisted synthesis as tools to identify and synthesize new inhibitors of mycobacterium tuberculosis. Chemmedchem. 1: 973-89. PMID 16892466 DOI: 10.1002/Cmdc.200600026 |
0.693 |
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| 2006 |
Biava M, Porretta GC, Poce G, Supino S, Deidda D, Pompei R, Molicotti P, Manetti F, Botta M. Antimycobacterial agents. Novel diarylpyrrole derivatives of BM212 endowed with high activity toward Mycobacterium tuberculosis and low cytotoxicity. Journal of Medicinal Chemistry. 49: 4946-52. PMID 16884306 DOI: 10.1021/Jm0602662 |
0.418 |
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| 2006 |
Tafi A, Angeli L, Venturini G, Travagli M, Corelli F, Botta M. Computational studies of competitive inhibitors of nitric oxide synthase (NOS) enzymes: towards the development of powerful and isoform-selective inhibitors. Current Medicinal Chemistry. 13: 1929-46. PMID 16842203 DOI: 10.2174/092986706777585031 |
0.347 |
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| 2006 |
Cona A, Rea G, Botta M, Corelli F, Federico R, Angelini R. Flavin-containing polyamine oxidase is a hydrogen peroxide source in the oxidative response to the protein phosphatase inhibitor cantharidin in Zea mays L. Journal of Experimental Botany. 57: 2277-89. PMID 16831849 DOI: 10.1093/Jxb/Erj195 |
0.309 |
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| 2006 |
Tafi A, Bernardini C, Botta M, Corelli F, Andreini M, Martinelli A, Ortore G, Baraldi PG, Fruttarolo F, Borea PA, Tuccinardi T. Pharmacophore based receptor modeling: the case of adenosine A3 receptor antagonists. An approach to the optimization of protein models. Journal of Medicinal Chemistry. 49: 4085-97. PMID 16821770 DOI: 10.1021/Jm051112+ |
0.353 |
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| 2006 |
Magnani M, Ortuso F, Soro S, Alcaro S, Tramontano A, Botta M. The betaI/betaIII-tubulin isoforms and their complexes with antimitotic agents. Docking and molecular dynamics studies. The Febs Journal. 273: 3301-10. PMID 16803461 DOI: 10.1111/J.1742-4658.2006.05340.X |
0.314 |
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| 2006 |
Manetti F, Locatelli GA, Maga G, Schenone S, Modugno M, Forli S, Corelli F, Botta M. A combination of docking/dynamics simulations and pharmacophoric modeling to discover new dual c-Src/Abl kinase inhibitors. Journal of Medicinal Chemistry. 49: 3278-86. PMID 16722646 DOI: 10.1021/Jm060236Z |
0.388 |
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| 2006 |
Manetti F, Tintori C, Armand-Ugón M, Clotet-Codina I, Massa S, Ragno R, Esté JA, Botta M. A combination of molecular dynamics and docking calculations to explore the binding mode of ADS-J1, a polyanionic compound endowed with anti-HIV-1 activity. Journal of Chemical Information and Modeling. 46: 1344-51. PMID 16711753 DOI: 10.1021/Ci050414H |
0.319 |
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| 2006 |
Mugnaini C, Manetti F, Esté JA, Clotet-Codina I, Maga G, Cancio R, Botta M, Corelli F. Synthesis and biological investigation of S-aryl-S-DABO derivatives as HIV-1 inhibitors. Bioorganic & Medicinal Chemistry Letters. 16: 3541-4. PMID 16621553 DOI: 10.1016/J.Bmcl.2006.03.080 |
0.369 |
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| 2006 |
Bianchi M, Polticelli F, Ascenzi P, Botta M, Federico R, Mariottini P, Cona A. Inhibition of polyamine and spermine oxidases by polyamine analogues. The Febs Journal. 273: 1115-23. PMID 16519678 DOI: 10.1111/J.1742-4658.2006.05137.X |
0.359 |
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| 2006 |
Carraro F, Naldini A, Pucci A, Locatelli GA, Maga G, Schenone S, Bruno O, Ranise A, Bondavalli F, Brullo C, Fossa P, Menozzi G, Mosti L, Modugno M, Tintori C, ... ... Botta M, et al. Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation. Journal of Medicinal Chemistry. 49: 1549-61. PMID 16509573 DOI: 10.1021/Jm050603R |
0.393 |
|
| 2006 |
Manetti F, Schenone S, Bondavalli F, Brullo C, Bruno O, Ranise A, Mosti L, Menozzi G, Fossa P, Trincavelli ML, Martini C, Martinelli A, Tintori C, Botta M. Synthesis and 3D QSAR of new pyrazolo[3,4-b]pyridines: potent and selective inhibitors of A1 adenosine receptors. Journal of Medicinal Chemistry. 48: 7172-85. PMID 16279775 DOI: 10.1021/Jm050407K |
0.367 |
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| 2006 |
Paladino A, Mugnaini C, Botta M, Corelli F. A new linker for anchoring/masking primary amines on solid support. Organic Letters. 7: 565-8. PMID 15704895 DOI: 10.1021/Ol047710K |
0.35 |
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| 2006 |
Radi M, Petricci E, Maga G, Corelli F, Botta M. Parallel solution-phase synthesis of 4-dialkylamino-2-methylsulfonyl-6-vinylpyrimidines. Journal of Combinatorial Chemistry. 7: 117-22. PMID 15638490 DOI: 10.1021/Cc049880U |
0.321 |
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| 2006 |
Renzulli ML, Rocheblave L, Avramova SI, Galletti E, Castagnolo D, Maccari L, Forli S, Manetti F, Corelli F, Botta M. A pharmacophore modeling approach to design new taxol® mimics: towards the synthesis of potential anticancer and MDR-reversing agent Arkivoc. 2006: 111-130. DOI: 10.3998/Ark.5550190.0007.812 |
0.69 |
|
| 2006 |
Petricci E, Mugnaini C, Radi M, Togninelli A, Bernardini C, Manetti F, Parlato MC, Renzulli ML, Alongi M, Falciani C, Corelli F, Botta M. Towards new methodologies for the synthesis of biologically interesting 6-substituted pyrimidines and 4(3H)-pyrimidinones Arkivoc. 2006: 452-478. DOI: 10.3998/Ark.5550190.0007.732 |
0.453 |
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| 2006 |
Botta M, Radi M, Spinosa R, Cristina Parlato M, Corelli F. Exploring the Synthesis of Masked Phosphoramido 6-Vinylcytidine Derivatives as Building Blocks for Cross-Linking Oligonucleotides Heterocycles. 69: 151. DOI: 10.3987/Com-06-S(O)3 |
0.381 |
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| 2006 |
Togninelli A, Carmi C, Petricci E, Mugnaini C, Massa S, Corelli F, Botta M. Solution-phase parallel synthesis of S-DABO analogues Tetrahedron Letters. 47: 65-67. DOI: 10.1016/J.Tetlet.2005.10.142 |
0.412 |
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| 2005 |
Manetti F, Esté JA, Clotet-Codina I, Armand-Ugón M, Maga G, Crespan E, Cancio R, Mugnaini C, Bernardini C, Togninelli A, Carmi C, Alongi M, Petricci E, Massa S, Corelli F, ... Botta M, et al. Parallel solution-phase and microwave-assisted synthesis of new S-DABO derivatives endowed with subnanomolar anti-HIV-1 activity. Journal of Medicinal Chemistry. 48: 8000-8. PMID 16335924 DOI: 10.1021/Jm050744T |
0.381 |
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| 2005 |
Mugnaini C, Petricci E, Corelli F, Botta M. Combinatorial chemistry as a tool for targeting different stages of the replicative HIV-1 cycle. Combinatorial Chemistry & High Throughput Screening. 8: 387-401. PMID 16101579 DOI: 10.2174/1386207054546504 |
0.329 |
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| 2005 |
Di Santo R, Tafi A, Costi R, Botta M, Artico M, Corelli F, Forte M, Caporuscio F, Angiolella L, Palamara AT. Antifungal agents. 11. N-substituted derivatives of 1-[(aryl)(4-aryl-1H-pyrrol-3-yl)methyl]-1H-imidazole: synthesis, anti-Candida activity, and QSAR studies. Journal of Medicinal Chemistry. 48: 5140-53. PMID 16078834 DOI: 10.1021/Jm048997U |
0.412 |
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| 2005 |
Biava M, Porretta GC, Cappelli A, Vomero S, Manetti F, Botta M, Sautebin L, Rossi A, Makovec F, Anzini M. 1,5-Diarylpyrrole-3-acetic acids and esters as novel classes of potent and highly selective cyclooxygenase-2 inhibitors. Journal of Medicinal Chemistry. 48: 3428-32. PMID 15857149 DOI: 10.1021/Jm049121Q |
0.393 |
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| 2005 |
Patanè E, Pittalà V, Guerrera F, Salerno L, Romeo G, Siracusa MA, Russo F, Manetti F, Botta M, Mereghetti I, Cagnotto A, Mennini T. Synthesis of 3-arylpiperazinylalkylpyrrolo[3,2-d]pyrimidine-2,4-dione derivatives as novel, potent, and selective alpha1-adrenoceptor ligands. Journal of Medicinal Chemistry. 48: 2420-31. PMID 15801833 DOI: 10.1021/Jm040870H |
0.384 |
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| 2005 |
Corelli F, Botta M, Lossani A, Pasquini S, Spadari S, Focher F. Microwave-assisted synthesis and biological evaluation of novel uracil derivatives inhibiting human thymidine phosphorylase. Farmaco (Societa Chimica Italiana : 1989). 59: 987-92. PMID 15598434 DOI: 10.1016/J.Farmac.2004.08.007 |
0.456 |
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| 2005 |
Schenone S, Bruno O, Bondavalli F, Ranise A, Mosti L, Menozzi G, Fossa P, Donnini S, Santoro A, Ziche M, Manetti F, Botta M. Antiproliferative activity of new 1-aryl-4-amino-1H-pyrazolo[3,4-d]pyrimidine derivatives toward the human epidermoid carcinoma A431 cell line. European Journal of Medicinal Chemistry. 39: 939-46. PMID 15501543 DOI: 10.1016/J.Ejmech.2004.07.010 |
0.356 |
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| 2005 |
Radi M, Mugnaini C, Petricci E, Corelli F, Botta M. Synthesis of reactive cytidine derivatives as building blocks for cross-linking oligonucleotides Tetrahedron Letters. 46: 4361-4364. DOI: 10.1016/J.Tetlet.2005.04.083 |
0.365 |
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| 2005 |
Castagnolo D, Renzulli ML, Galletti E, Corelli F, Botta M. Microwave-assisted ethylene–alkyne cross-metathesis: synthesis of chiral 2-(N-1-acetyl-1-arylmethyl)-1,3-butadienes Tetrahedron: Asymmetry. 16: 2893-2896. DOI: 10.1016/J.Tetasy.2005.08.002 |
0.666 |
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| 2004 |
Schenone S, Bruno O, Ranise A, Bondavalli F, Brullo C, Fossa P, Mosti L, Menozzi G, Carraro F, Naldini A, Bernini C, Manetti F, Botta M. New pyrazolo[3,4-d]pyrimidines endowed with A431 antiproliferative activity and inhibitory properties of Src phosphorylation. Bioorganic & Medicinal Chemistry Letters. 14: 2511-7. PMID 15109642 DOI: 10.1016/J.Bmcl.2004.03.013 |
0.381 |
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| 2004 |
Cona A, Manetti F, Leone R, Corelli F, Tavladoraki P, Polticelli F, Botta M. Molecular basis for the binding of competitive inhibitors of maize polyamine oxidase. Biochemistry. 43: 3426-35. PMID 15035614 DOI: 10.1021/Bi036152Z |
0.325 |
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| 2004 |
Carraro F, Pucci A, Naldini A, Schenone S, Bruno O, Ranise A, Bondavalli F, Brullo C, Fossa P, Menozzi G, Mosti L, Manetti F, Botta M. Pyrazolo[3,4-d]pyrimidines endowed with antiproliferative activity on ductal infiltrating carcinoma cells. Journal of Medicinal Chemistry. 47: 1595-8. PMID 15027847 DOI: 10.1021/Jm034257U |
0.35 |
|
| 2004 |
Betti L, Floridi M, Giannaccini G, Manetti F, Paparelli C, Strappaghetti G, Botta M. Design, synthesis, and alpha(1)-adrenoceptor binding properties of new arylpiperazine derivatives bearing a flavone nucleus as the terminal heterocyclic molecular portion. Bioorganic & Medicinal Chemistry. 12: 1527-35. PMID 15018926 DOI: 10.1016/J.Bmc.2003.12.033 |
0.362 |
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| 2004 |
Manetti F, Maccari L, Corelli F, Botta M. 3D QSAR models of interactions between beta-tubulin and microtubule stabilizing antimitotic agents (MSAA): a survey on taxanes and epothilones. Current Topics in Medicinal Chemistry. 4: 203-17. PMID 14754454 DOI: 10.2174/1568026043451465 |
0.344 |
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| 2004 |
Maccari L, Manetti F, Corelli F, Botta M. 3D QSAR studies for the beta-tubulin binding site of microtubule-stabilizing anticancer agents (MSAAs): a pseudoreceptor model for taxanes based on the experimental structure of tubulin. Farmaco (Societa Chimica Italiana : 1989). 58: 659-68. PMID 13679158 DOI: 10.1016/S0014-827X(03)00099-5 |
0.356 |
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| 2004 |
Manetti F, Forli S, Maccari L, Corelli F, Botta M. 3D QSAR studies of the interaction between beta-tubulin and microtubule stabilizing antimitotic agents (MSAA). A combined pharmacophore generation and pseudoreceptor modeling approach applied to taxanes and epothilones. Farmaco (Societa Chimica Italiana : 1989). 58: 357-61. PMID 12729829 DOI: 10.1016/S0014-827X(03)00052-1 |
0.348 |
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| 2004 |
Parlato MC, Mugnaini C, Renzulli ML, Corelli F, Botta M. Solid phase synthesis of 5,6-disubstituted pyrimidinone and pyrimidindione derivatives Arkivoc. 2004: 349-363. DOI: 10.3998/Ark.5550190.0005.530 |
0.311 |
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| 2004 |
Renzulli ML, Rocheblave L, Avramova S, Corelli F, Botta M. Studies Toward Taxuspine X (II), a Potent Multidrug-Resistance Reversing Agent, via Ring Closing Metathesis Strategy Cheminform. 35. DOI: 10.1016/J.Tetlet.2004.04.147 |
0.342 |
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| 2004 |
Castagnolo D, Armaroli S, Corelli F, Botta M. Enantioselective synthesis of 1-aryl-2-propenylamines: a new approach to a stereoselective synthesis of the Taxol® side chain Tetrahedron: Asymmetry. 15: 941-949. DOI: 10.1016/J.Tetasy.2004.01.035 |
0.651 |
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| 2003 |
Botta B, Ricciardi P, Galeffi C, Botta M, Tafi A, Pogni R, Iacovino R, Garella I, Di Blasio B, Delle Monache G. Synthesis and molecular modelling studies of resorcin[4]arene-capped porphyrins. Organic & Biomolecular Chemistry. 1: 3131-7. PMID 14518138 DOI: 10.1039/B303741J |
0.366 |
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| 2003 |
Botta B, Carmignani M, Volpe AR, Botta M, Corelli F, Delle Monache G. Novel hypotensive agents from Verbesina caracasana: structure, synthesis and pharmacology. Current Medicinal Chemistry. 10: 1845-62. PMID 12871108 DOI: 10.2174/0929867033456990 |
0.346 |
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| 2003 |
Romeo G, Materia L, Manetti F, Cagnotto A, Mennini T, Nicoletti F, Botta M, Russo F, Minneman KP. New pyrimido[5,4-b]indoles as ligands for alpha(1)-adrenoceptor subtypes. Journal of Medicinal Chemistry. 46: 2877-94. PMID 12825930 DOI: 10.1021/Jm0307741 |
0.307 |
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| 2003 |
Manetti F, Botta M. Small-molecule inhibitors of fibroblast growth factor receptor (FGFR) tyrosine kinases (TK). Current Pharmaceutical Design. 9: 567-81. PMID 12570804 DOI: 10.2174/1381612033391487 |
0.354 |
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| 2003 |
Mugnaini C, Botta M, Coletta M, Corelli F, Focher F, Marini S, Renzulli ML, Verri A. Research on L-nucleosides. Synthesis and biological evaluation of a series of L- and D-2',3'-dideoxy-3'-[tris(methylthio)methyl]-beta-pentofuranosyl nucleosides. Bioorganic & Medicinal Chemistry. 11: 357-66. PMID 12517431 DOI: 10.1016/S0968-0896(02)00460-1 |
0.389 |
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| 2003 |
Betti L, Floridi M, Giannaccini G, Manetti F, Strappaghetti G, Tafi A, Botta M. alpha1-Adrenoceptor antagonists. 5. Pyridazinone-arylpiperazines. Probing the influence on affinity and selectivity of both ortho-alkoxy groups at the arylpiperazine moiety and cyclic substituents at the pyridazinone nucleus. Bioorganic & Medicinal Chemistry Letters. 13: 171-3. PMID 12482417 DOI: 10.1016/S0960-894X(02)00932-0 |
0.352 |
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| 2003 |
Botta M, Piero Stasi L, Mugnaini C, Alcaro S, Corelli F. Synthesis and Conformational Studies of 3'-(2'-Aminoborane-2'-deoxyuridyl)-5'-thymidilyl Hydrogen Phosphate to be Used in the Construction of Oligonucleotide Sequences Heterocycles. 61: 403. DOI: 10.3987/Com-03-S56 |
0.333 |
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| 2003 |
Paolini L, Petricci E, Corelli F, Botta M. Microwave-Assisted C-5 Iodination of Substituted Pyrimidinones and Pyrimidine Nucleosides. Cheminform. 34. DOI: 10.1055/S-2003-39159 |
0.316 |
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| 2002 |
Bondavalli F, Botta M, Bruno O, Ciacci A, Corelli F, Fossa P, Lucacchini A, Manetti F, Martini C, Menozzi G, Mosti L, Ranise A, Schenone S, Tafi A, Trincavellic ML. Synthesis, molecular modeling studies, and pharmacological activity of selective A(1) receptor antagonists. Journal of Medicinal Chemistry. 45: 4875-87. PMID 12383013 DOI: 10.1021/Jm0209580 |
0.376 |
|
| 2002 |
Betti L, Botta M, Corelli F, Floridi M, Giannaccini G, Maccari L, Manetti F, Strappaghetti G, Tafi A, Corsano S. Alpha(1)-adrenoceptor antagonists. 4. Pharmacophore-based design, synthesis, and biological evaluation of new imidazo-, benzimidazo-, and indoloarylpiperazine derivatives. Journal of Medicinal Chemistry. 45: 3603-11. PMID 12166933 DOI: 10.1021/Jm011077G |
0.344 |
|
| 2002 |
Tafi A, Costi R, Botta M, Di Santo R, Corelli F, Massa S, Ciacci A, Manetti F, Artico M. Antifungal agents. 10. New derivatives of 1-[(aryl)[4-aryl-1H-pyrrol-3-yl]methyl]-1H-imidazole, synthesis, anti-Candida activity, and quantitative structure-analysis relationship studies Journal of Medicinal Chemistry. 45: 2720-2732. PMID 12061875 DOI: 10.1021/Jm011087H |
0.434 |
|
| 2002 |
Saladino R, Ciambecchini U, Maga G, Mastromarino P, Conti C, Botta M. A new and efficient synthesis of substituted 6-[(2'-dialkylamino)ethyl] pyrimidine and 4-N,N-dialkyl-6-vinyl-cytosine derivatives and evaluation of their anti-rubella activity. Bioorganic & Medicinal Chemistry. 10: 2143-53. PMID 11983510 DOI: 10.1016/S0968-0896(02)00077-9 |
0.419 |
|
| 2002 |
Botta B, Delle Monache G, Zappia G, Misiti D, Baratto MC, Pogni R, Gacs-Baitz E, Botta M, Corelli F, Manetti F, Tafi A. Synthesis and interaction with copper(II) cations of cyano- and aminoresorcin[4]arenes. The Journal of Organic Chemistry. 67: 1178-83. PMID 11846660 DOI: 10.1021/Jo010844G |
0.33 |
|
| 2002 |
Betti L, Botta M, Corelli F, Floridi M, Fossa P, Giannaccini G, Manetti F, Strappaghetti G, Corsano S. alpha(1)-Adrenoceptor antagonists. Rational design, synthesis and biological evaluation of new trazodone-like compounds. Bioorganic & Medicinal Chemistry Letters. 12: 437-40. PMID 11814815 DOI: 10.1016/S0960-894X(01)00772-7 |
0.343 |
|
| 2002 |
Barbaro R, Betti L, Botta M, Corelli F, Giannaccini G, Maccari L, Manetti F, Strappaghetti G, Corsano S. Synthesis and biological activity of new 1,4-benzodioxan-arylpiperazine derivatives. Further validation of a pharmacophore model for alpha(1)-adrenoceptor antagonists. Bioorganic & Medicinal Chemistry. 10: 361-9. PMID 11741785 DOI: 10.1016/S0968-0896(01)00286-3 |
0.381 |
|
| 2002 |
Saladino R, Crestini C, Palamara AT, Danti MC, Manetti F, Corelli F, Garaci E, Botta M. Synthesis, biological evaluation, and pharmacophore generation of uracil, 4(3H)-pyrimidinone, and uridine derivatives as potent and selective inhibitors of parainfluenza 1 (Sendai) virus. Journal of Medicinal Chemistry. 44: 4554-62. PMID 11741474 DOI: 10.1021/Jm010938I |
0.414 |
|
| 2002 |
Botta M, Corelli F, Petricci E, Seri C. New Solid-supported Reagents (SSRs) for Selective Acylation of Amines Heterocycles. 56: 369. DOI: 10.3987/Com-01-S(K)50 |
0.317 |
|
| 2002 |
Petricci E, Renzulli M, Radi M, Corelli F, Botta M. Solid-phase synthesis (SPS) of substituted uracils via Oxone® cleavage methodology Tetrahedron Letters. 43: 9667-9670. DOI: 10.1016/S0040-4039(02)02380-8 |
0.315 |
|
| 2002 |
Petricci E, Botta M, Corelli F, Mugnaini C. An improved synthesis of solid-supported reagents (SSRs) for selective acylation of amines by microwave irradiation Tetrahedron Letters. 43: 6507-6509. DOI: 10.1016/S0040-4039(02)01478-8 |
0.304 |
|
| 2001 |
Carmignani M, Volpe AR, Botta B, Espinal R, De Bonnevaux SC, De Luca C, Botta M, Corelli F, Tafi A, Sacco R, Delle Monache G. Novel hypotensive agents from Verbesina caracasana. 8. Synthesis and pharmacology of (3,4-dimethoxycinnamoyl)-N(1)-agmatine and synthetic analogues. Journal of Medicinal Chemistry. 44: 2950-8. PMID 11520203 DOI: 10.1021/Jm001017V |
0.315 |
|
| 2001 |
Manetti F, Corelli F, Biava M, Fioravanti R, Porretta GC, Botta M. Building a pharmacophore model for a novel class of antitubercular compounds. Farmaco (Societa Chimica Italiana : 1989). 55: 484-91. PMID 11204750 DOI: 10.1016/S0014-827X(00)00072-0 |
0.362 |
|
| 2001 |
Botta M, Manetti F, Corelli F. Fibroblast growth factors and their inhibitors. Current Pharmaceutical Design. 6: 1897-924. PMID 11102567 DOI: 10.2174/1381612003398528 |
0.359 |
|
| 2001 |
Manna F, Chimenti F, Bolasco A, Bizzarri B, Botta M, Tafi A, Filippelli A, Rossi S. Synthesis and preliminary biological evaluation of 4,6-disubstituted 3-cyanopyridin-2(1H)-ones, a new class of calcium entry blockers. Bioorganic & Medicinal Chemistry Letters. 10: 1883-5. PMID 10969991 DOI: 10.1016/S0960-894X(00)00361-9 |
0.306 |
|
| 2001 |
Botta M, Corelli F, Manetti F, Mugnaini C, Tafi A. Rational design and synthesis of homochiral azole antifungal agents Pure and Applied Chemistry. 73: 1477-1485. DOI: 10.1351/Pac200173091477 |
0.412 |
|
| 2001 |
Botta M, Corelli F, Maga G, Manetti F, Renzulli M, Spadari S. Research on anti-HIV-1 agents. Part 2: Solid-phase synthesis, biological evaluation and molecular modeling studies of 2,5,6-trisubstituted-4(3H)-pyrimidinones targeting HIV-1 reverse transcriptase Tetrahedron. 57: 8357-8367. DOI: 10.1016/S0040-4020(01)00815-8 |
0.385 |
|
| 2000 |
Manetti F, Mileto D, Corelli F, Soro S, Palocci C, Cernia E, D'Acquarica I, Lotti M, Alberghina L, Botta M. Design and realization of a tailor-made enzyme to modify the molecular recognition of 2-arylpropionic esters by Candida rugosa lipase. Biochimica Et Biophysica Acta. 1543: 146-58. PMID 11087950 DOI: 10.1016/S0167-4838(00)00185-0 |
0.313 |
|
| 2000 |
Botta M, Corelli F, Gasparrini F, Messina F, Mugnaini C. Chiral azole derivatives. 4. Enantiomers of bifonazole and related antifungal agents: synthesis, configuration assignment, and biological evaluation. The Journal of Organic Chemistry. 65: 4736-9. PMID 10959884 DOI: 10.1021/Jo991937P |
0.36 |
|
| 2000 |
Gentile G, Fattori D, Botta M, Corelli F, Fusar-Bassini D, Lamba D. Synthesis of dimeric and tetrameric macrolactams with cytotoxic activity 1 Canadian Journal of Chemistry. 78: 925-934. DOI: 10.1139/Cjc-78-6-925 |
0.422 |
|
| 2000 |
Messina F, Botta M, Corelli F, Paladino A. Chiral azole derivatives. Part 5: † †For Part 4, see Ref. 1. Synthesis of enantiomerically pure 1-[α-(benzofuran-2-yl)arylmethyl]-1 H -1,2,4-triazoles, antifungal and antiaromatase agents Tetrahedron: Asymmetry. 11: 4895-4901. DOI: 10.1016/S0957-4166(00)00486-9 |
0.312 |
|
| 2000 |
Messina F, Botta M, Corelli F, Villani C. Stereoselective synthesis of α-aryl-2-benzofuranmethanamines and α-aryl-1H-indole-2-methanamines through palladium-mediated annulation of chiral α-arylpropargylamines Tetrahedron: Asymmetry. 11: 1681-1685. DOI: 10.1016/S0957-4166(00)00131-2 |
0.35 |
|
| 1999 |
Wang M, Xia X, Kim Y, Hwang D, Jansen JM, Botta M, Liotta DC, Snyder JP. A unified and quantitative receptor model for the microtubule binding of paclitaxel and epothilone Organic Letters. 1: 43-46. PMID 10822530 DOI: 10.1021/Ol990521V |
0.332 |
|
| 1999 |
Botta M, Occhionero F, Nicoletti R, Mastromarino P, Conti C, Magrini M, Saladino R. Synthesis and biological evaluation of 2-methoxy- and 2-methylthio-6-[2'-alkylamino)ethyl]-4(3H)-pyrimidinones with anti-rubella virus activity. Bioorganic & Medicinal Chemistry. 7: 1925-31. PMID 10530941 DOI: 10.1016/S0968-0896(99)00111-X |
0.344 |
|
| 1999 |
Saladino R, Danti MC, Mincione E, Crestini C, Palamara AT, Savini P, Marini S, Botta M. A potent and selective inhibition of parainfluenza 1 (Sendai) virus by new 6-oxiranyl-, 6-methyloxiranyluracils, and 4(3H)-pyrimidinone derivatives. Bioorganic & Medicinal Chemistry Letters. 8: 1833-8. PMID 9873443 DOI: 10.1016/S0960-894X(98)00314-X |
0.344 |
|
| 1999 |
Botta M, Saladino R, Stasi L, Ciambecchini U, Nicoletti R. Recent Advances in the Synthesis of 6-Vinyl-N,N-Dialkylcytosine Derivatives Nucleosides and Nucleotides. 18: 555-556. DOI: 10.1080/15257779908041492 |
0.306 |
|
| 1999 |
Orvieto F, Botta M, Corelli F, Harper S. An Expedient Synthesis of 14,14-Dimethyl-3,7-diazatricyclo[8.3.11,10.03.8]tetradec-7-en-4-one-12α-yl Cinnamate, an Unusual Heterocyclic Compound Resembling the A/B/C Core of Taxanes Synthetic Communications. 29: 3635-3649. DOI: 10.1080/00397919908085999 |
0.408 |
|
| 1999 |
Messina F, Botta M, Corelli F, Mugnaini C. Chiral azole derivatives, 3. Synthesis of the enantiomers of the potent aromatase inhibitor 1-[2-benzofuranyl(4-chlorophenyl)methyl]-1H-imidazole Tetrahedron Letters. 40: 7289-7292. DOI: 10.1016/S0040-4039(99)01569-5 |
0.41 |
|
| 1999 |
Saladino R, Stasi L, Nicoletti R, Crestini C, Botta M. Umpolung of Reactivity of Lithium Trimethylsilyldiazomethane at the C-5 Position of 6-Substituted Uracil Derivatives European Journal of Organic Chemistry. 1999: 2751-2755. DOI: 10.1002/(Sici)1099-0690(199911)1999:11<2751::Aid-Ejoc2751>3.0.Co;2-I |
0.325 |
|
| 1998 |
Manetti F, Cappello V, Botta M, Corelli F, Mongelli N, Biasoli G, Borgia AL, Ciomei M. Synthesis and binding mode of heterocyclic analogues of suramin inhibiting the human basic fibroblast growth factor Bioorganic and Medicinal Chemistry. 6: 947-958. PMID 9730230 DOI: 10.1016/S0968-0896(98)00052-2 |
0.346 |
|
| 1998 |
Saladino R, Stasi L, Volpe G, Nicoletti R, Botta M. Reactivity of Dimethylphenylsilyllithium toward 5- and 6-Substituted 1,3-Dimethyluracil Derivatives Heterocycles. 48: 2601. DOI: 10.3987/Com-98-8270 |
0.33 |
|
| 1998 |
Nizi E, Botta M, Corelli F, Manetti F, Messina F, Maga G. Solid phase synthesis of 2,6-disubstituted-4(3H)-pyrimidinones targeting HIV-1 reverse transcriptase Tetrahedron Letters. 39: 3307-3310. DOI: 10.1016/S0040-4039(97)84377-8 |
0.315 |
|
| 1997 |
Botta M, Cernia E, Corelli F, Manetti F, Soro S. Probing the substrate specificity for lipases. II. Kinetic and modeling studies on the molecular recognition of 2-arylpropionic esters by Candida rugosa and Rhizomucor miehei lipases. Biochimica Et Biophysica Acta. 1337: 302-10. PMID 9048908 DOI: 10.1016/S0167-4838(96)00181-1 |
0.332 |
|
| 1997 |
Corelli F, Manetti F, Tafi A, Campiani G, Nacci V, Botta M. Diltiazem-like calcium entry blockers: a hypothesis of the receptor-binding site based on a comparative molecular field analysis model. Journal of Medicinal Chemistry. 40: 125-31. PMID 9016337 DOI: 10.1021/Jm9605647 |
0.348 |
|
| 1997 |
Artico M, Botta M, Corelli F, Mai A, Massa S, Ragno R. Investigation on QSAR and binding mode of a new class of human rhinovirus-14 inhibitors by CoMFA and docking experiments. Bioorganic & Medicinal Chemistry. 4: 1715-24. PMID 8931942 DOI: 10.1016/0968-0896(96)00184-8 |
0.389 |
|
| 1997 |
Botta B, Delle Monache G, Salvatore P, Gasparrini F, Villani C, Botta M, Corelli F, Tafi A, Gacs-Baitz E, Santini A, Carvalho CF, Misiti D. Synthesis ofC-Alkylcalix[4]arenes. 4. Design, Synthesis, and Computational Studies of Novel Chiral Amido[4]resorcinarenes The Journal of Organic Chemistry. 62: 932-938. DOI: 10.1021/Jo962018R |
0.362 |
|
| 1997 |
Botta B, Delle Monache G, De Rosa MC, Seri C, Benedetti E, Iacovino R, Botta M, Corelli F, Masignani V, Tafi A, Gacs-Baitz E, Santini A, Misiti D. Synthesis ofC-Alkylcalix[4]arenes. 5. Design, Synthesis, Computational Studies, and Homodimerization of Polymethylene-Bridged Resorc[4]arenes The Journal of Organic Chemistry. 62: 1788-1794. DOI: 10.1021/Jo9619692 |
0.316 |
|
| 1997 |
Botta M, Occhionero F, Saladino R, Crestini C, Nicoletti R. An unexpected and efficient direct nucleophilic C-4 hydroxy substitution on 2-methoxy- and 2-methylthio-4(3)-pyrimidinones bearing a diethylamino moiety on the C-6 side chain Tetrahedron Letters. 38: 8249-8252. DOI: 10.1016/S0040-4039(97)10159-9 |
0.303 |
|
| 1997 |
Cabri W, Botta M, Corelli F, Messina F. Palladium-catalysed reduction of 3-substituted cephems. A high yield approach to ceftizoxime synthetic intermediates Tetrahedron Letters. 38: 3291-3292. DOI: 10.1016/S0040-4039(97)00588-1 |
0.32 |
|
| 1997 |
Botta M, Crescenza A, Magara W, Corelli F. Cyclic dipeptides. 21. A simple synthesis of methyl (6R)-6-tert-butoxycarbonylamino-4,5,6,7-tetrahydro-2-methyl-5-oxo-1,4-thiazepine-3-carboxylate, a useful intermediate for the preparation of potential antihypertensive agents Tetrahedron Letters. 38: 2775-2778. DOI: 10.1016/S0040-4039(97)00468-1 |
0.371 |
|
| 1997 |
Corelli F, Dei D, Menichincheri M, Snyder JP, Botta M. Synthesis of bicyclo[9.3.1]pentadecane derivatives, interesting intermediates for the preparation of taxuspine U and related diterpenoids Tetrahedron Letters. 38: 2759-2762. DOI: 10.1016/S0040-4039(97)00463-2 |
0.386 |
|
| 1997 |
Saladino R, Stasi L, Crestini C, Nicoletti R, Botta M. Reactivity of lithium trimethylsilyldiazomethane and diazomethane toward the 5,6-double bond of uracil and uridine derivatives Tetrahedron. 53: 7045-7056. DOI: 10.1016/S0040-4020(97)00402-X |
0.323 |
|
| 1996 |
Campiani G, Fiorini I, De Filippis MP, Ciani SM, Garofalo A, Nacci V, Giorgi G, Sega A, Botta M, Chiarini A, Budriesi R, Bruni G, Romeo MR, Manzoni C, Mennini T. Cardiovascular characterization of pyrrolo[2,1-d][1,5]benzothiazepine derivatives binding selectively to the peripheral-type benzodiazepine receptor (PBR): from dual PBR affinity and calcium antagonist activity to novel and selective calcium entry blockers. Journal of Medicinal Chemistry. 39: 2922-38. PMID 8709127 DOI: 10.1021/Jm960162Z |
0.329 |
|
| 1996 |
Corelli F, Dei D, Delle Monache GD, Botta B, De Luca C, Carmignani M, Volpe AR, Botta M. Synthesis and preliminary pharmacological evaluation of analogues of caracasanamide, a hypotensive natural product Bioorganic and Medicinal Chemistry Letters. 6: 653-658. DOI: 10.1016/0960-894X(96)00079-0 |
0.422 |
|
| 1996 |
Delle Monache G, Botta B, Delle Monache F, Espinal R, De Bonnevaux SC, De Luca C, Botta M, Corelli F, Dei D, Gacs-Baitz E, Carmignani M. Caracasandiamide, a truxinic hypotensive agent from Verbesina caracasana Bioorganic & Medicinal Chemistry Letters. 6: 233-238. DOI: 10.1016/0960-894X(96)00007-8 |
0.339 |
|
| 1996 |
Botta M, Summa V, Corelli F, Di Pietro G, Lombardi P. Synthesis of aryl 2-benzofuranyl and aryl 2-indolyl carbinols of high enantiomeric purity via palladium-catalyzed heteroannulation of chiral arylpropargylic alcohols Tetrahedron: Asymmetry. 7: 1263-1266. DOI: 10.1016/0957-4166(96)00138-3 |
0.326 |
|
| 1996 |
Botta M, Crucianelli M, Saladino R, Mozzetti C, Nicoletti R. Studies on the reactivity of cephalosporins. 6. Ozonolysis of Δ2-cephem derivatives as a new entry to highly functionalized 2-oxoazetidine and 2-oxoazetidine-4-sulfenic acid derivatives Tetrahedron. 52: 10205-10214. DOI: 10.1016/0040-4020(96)00555-8 |
0.353 |
|
| 1995 |
Campiani G, Garofalo A, Fiorini I, Botta M, Nacci V, Tafi A, Chiarini A, Budriesi R, Bruni G, Romeo MR. Pyrrolo[2,1-c][1,4]benzothiazines: synthesis, structure-activity relationships, molecular modeling studies, and cardiovascular activity. Journal of Medicinal Chemistry. 38: 4393-410. PMID 7473567 DOI: 10.1021/Jm00022A005 |
0.383 |
|
| 1995 |
Botta B, Delle Monache G, De Rosa MC, Carbonetti A, Bacs-Baitz E, Botta M, Corelli F, Misiti D. Synthesis of C-Alkyl Calix[4]arenes. 3. Acid-Catalyzed Rearrangement of 2,6-Dimethoxycinnamate Prior to Tetramerization to Calix[4]arenes The Journal of Organic Chemistry. 60: 3657-3662. DOI: 10.1021/Jo00117A015 |
0.323 |
|
| 1995 |
Corelli F, Summa V, Brogi A, Monteagudo E, Botta M. Chiral Azole Derivatives. 2. Synthesis of Enantiomerically Pure 1-Alkylimidazoles The Journal of Organic Chemistry. 60: 2008-2015. DOI: 10.1021/Jo00112A023 |
0.338 |
|
| 1994 |
Botta M, Saladino R, Anzini M, Corelli F. Simplified Analogues of Acyclonucleosides. Synthesis of 6-[N-Alkyl-N-(4-hydroxybutyl)amino]pyrimidine Derivatives Nucleosides and Nucleotides. 13: 1769-1777. DOI: 10.1080/15257779408009479 |
0.397 |
|
| 1994 |
Botta B, Di Giovanni MC, Monache GD, De Rosa MC, Gacs-Baitz E, Botta M, Corelli F, Tafi A, Santini A. A Novel Route to Calix[4]arenes. 2. Solution- and Solid-State Structural Analyses and Molecular Modeling Studies The Journal of Organic Chemistry. 59: 1532-1541. DOI: 10.1021/Jo00085A047 |
0.305 |
|
| 1994 |
Campiani G, Garofalo A, Fiorini I, Nacci V, Botta M, Tafi A, Chiarini A, Budriesi R, Bruni G, Romeo M. Synthesis and “in vitro” cardiovascular activity of 4-aryl-2,3,3a,4-tetrahydro-1h-pyrrolo[2,1-c][1,4]benzothiazin-1-ones and 7-acetoxy-6-phenyl-7a,8,9,10-tetrahydropyrrolo [2,1,-d][1,5]benzothiazepin-10-one. Bioorganic & Medicinal Chemistry Letters. 4: 1235-1240. DOI: 10.1016/S0960-894X(01)80337-1 |
0.308 |
|
| 1994 |
Botta M, Summa V, Trapassi G, Monteagudo E, Corelli F. Stereospecific synthesis of 1-alkylimidazole derivatives via mitsunobu reactions Tetrahedron: Asymmetry. 5: 181-184. DOI: 10.1016/S0957-4166(00)86167-4 |
0.379 |
|
| 1993 |
Botta M, Saladino R, Lamba D, Nicoletti R. Researches on antiviral agents. 3. synthesis and transformations of racemic and chiral 6-oxiranyl pyrimidinones. Tetrahedron. 49: 6053-6070. DOI: 10.1016/S0040-4020(01)87190-8 |
0.336 |
|
| 1993 |
Garofalo A, Balconi G, Botta M, Corelli F, D'Incalci M, Fabrizi G, Fiorini I, Lamba D, Nacci V. Thioanalogues of anti-tumor antibiotics. II. Synthesis and preliminary in vitro cytotoxicity evaluation of tricyclic [1,4]benzothiazepine derivatives European Journal of Medicinal Chemistry. 28: 213-220. DOI: 10.1016/0223-5234(93)90136-3 |
0.422 |
|
| 1992 |
Botta M, Saladino R, Nicoletti R. One Step Synthesis of 5-Bromo-2-chloro-6-hydroxy-4-[N-(2,3-dibromopropyl)-N-alkylamino]pyrimidines, Useful Intermediates for the Preparation of Pteridine Derivatives and Related Analogues Heterocycles. 34: 729. DOI: 10.3987/Com-91-5953 |
0.354 |
|
| 1992 |
Campiani G, Nacci V, Garofalo A, Botta M, Fiorini I, Tafi A, Bruni G, Romeo M, Peres A, Bertollini L. Synthesis and preliminary biological evaluation of 1-aminomethyl-4-substituted-4-H-pyrrolo[2,1-C][1,4] benzothiazines, a new class of calcium antagonists. Bioorganic & Medicinal Chemistry Letters. 2: 1193-1198. DOI: 10.1016/S0960-894X(00)80212-7 |
0.306 |
|
| 1992 |
Monache GD, Botta B, Monache FD, Espinal R, De Bonnevaux SC, De Luca C, Botta M, Corelli F, Carmignani M. Caracasanamide, a novel hypotensive agent from Verbesina caracasana Bioorganic and Medicinal Chemistry Letters. 2: 415-418. DOI: 10.1016/S0960-894X(00)80159-6 |
0.356 |
|
| 1992 |
Botta M, Artico M, Massa S, Gambacorta A, Marongiu M, Pani A, La Colla P. Synthesis, antimicrobial and antiviral activities of isotrimethoprim and some related derivatives European Journal of Medicinal Chemistry. 27: 251-257. DOI: 10.1016/0223-5234(92)90009-P |
0.388 |
|
| 1991 |
Botta M, De Angelis F, Corelli F, Menichincheri M, Nicoletti R, Marongiu ME, Pani A, La Colla P. Antiviral agents: synthesis of furylpyrimidinones and evaluation of their cytostatic and antiviral activity. Archiv Der Pharmazie. 324: 203-7. PMID 1650546 DOI: 10.1002/Ardp.19913240403 |
0.327 |
|
| 1991 |
Gambacorta A, Turchetta S, Stefanelli S, Botta M. Bicyclo[3.3.1]nonanes as synthetic intermediates. Synthesis of 1-hydroxy-anti-8-acetylbicyclo[4.2.2]decane Tetrahedron Letters. 32: 6805-6808. DOI: 10.1016/S0040-4039(00)93608-6 |
0.349 |
|
| 1991 |
Gambacorta A, Turchetta S, Bovicelli P, Botta M. Synthesis of substituted cis-bicyclo[3.3.0]octane-1-carbonyl derivatives by stereospecific rearrangement of 1-chloro- 9-hydroxybicyclo [3.3.1] nonanes Tetrahedron. 47: 9097-9102. DOI: 10.1016/S0040-4020(01)86512-1 |
0.329 |
|
| 1990 |
Botta M, Saladino R, Gambacorta A, Nicoletti R. Researches on antiviral agents.2. Enantiospecific synthesis of 1,3-dimethyl-6-oxiranylpyrimidin-2,4-dione with anti-ASFV activity Tetrahedron: Asymmetry. 1: 441-444. DOI: 10.1016/S0957-4166(00)86348-X |
0.383 |
|
| 1989 |
Massa S, Mai A, Artico M, Corelli F, Botta M. Syntheses of 3b,4,6,7-Tetrahydro-5h,9h-pyrazino [2,1-c] phyrolo[1,2-a] [1,4] benzodiazepine, a valuable precursor of potential central nervous system agents Tetrahedron. 45: 2763-2772. DOI: 10.1016/S0040-4020(01)80106-X |
0.327 |
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