| Year |
Citation |
Score |
| 2022 |
Wilhelm P, Luna-Ramirez K, Chin YK, Dekan Z, Abraham N, Tae HS, Chow CY, Eagles DA, King GF, Lewis RJ, Adams DJ, Alewood PF. Cysteine-Rich α-Conotoxin SII Displays Novel Interactions at the Muscle Nicotinic Acetylcholine Receptor. Acs Chemical Neuroscience. PMID 35357806 DOI: 10.1021/acschemneuro.1c00857 |
0.393 |
|
| 2022 |
Finol-Urdaneta RK, Ziegman R, Dekan Z, McArthur JR, Heitmann S, Luna-Ramirez K, Tae HS, Mueller A, Starobova H, Chin YK, Wingerd JS, Undheim EAB, Cristofori-Armstrong B, Hill AP, Herzig V, ... ... Alewood PF, et al. Multitarget nociceptor sensitization by a promiscuous peptide from the venom of the King Baboon spider. Proceedings of the National Academy of Sciences of the United States of America. 119. PMID 35074873 DOI: 10.1073/pnas.2110932119 |
0.41 |
|
| 2021 |
Tae HS, Gao B, Jin AH, Alewood PF, Adams DJ. Globular and ribbon isomers of Conus geographus α-conotoxins antagonize human nicotinic acetylcholine receptors. Biochemical Pharmacology. 114638. PMID 34062129 DOI: 10.1016/j.bcp.2021.114638 |
0.346 |
|
| 2021 |
Walker AA, Robinson SD, Paluzzi JV, Merritt DJ, Nixon SA, Schroeder CI, Jin J, Goudarzi MH, Kotze AC, Dekan Z, Sombke A, Alewood PF, Fry BG, Epstein ME, Vetter I, et al. Production, composition, and mode of action of the painful defensive venom produced by a limacodid caterpillar, . Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33893140 DOI: 10.1073/pnas.2023815118 |
0.305 |
|
| 2021 |
Muttenthaler M, King GF, Adams DJ, Alewood PF. Trends in peptide drug discovery. Nature Reviews. Drug Discovery. PMID 33536635 DOI: 10.1038/s41573-020-00135-8 |
0.429 |
|
| 2020 |
Herzig V, Sunagar K, Wilson DTR, Pineda SS, Israel MR, Dutertre S, McFarland BS, Undheim EAB, Hodgson WC, Alewood PF, Lewis RJ, Bosmans F, Vetter I, King GF, Fry BG. Australian funnel-web spiders evolved human-lethal δ-hexatoxins for defense against vertebrate predators. Proceedings of the National Academy of Sciences of the United States of America. PMID 32958636 DOI: 10.1073/Pnas.2004516117 |
0.32 |
|
| 2020 |
Fernandez-Rojo MA, Brust A, Potriquet J, Daley J, Ragnarsson L, Andersson A, Mukhopadhyay P, Wilhelm P, Chin Y, Smallwood T, Clark R, King G, Ramm G, Waddell N, Lewis R, ... ... Alewood P, et al. The antiproliferative profile of a linear octopus-derived peptide in melanoma of BRAF-mutation. Toxicon : Official Journal of the International Society On Toxinology. 177: S2. PMID 32634945 DOI: 10.1016/J.Toxicon.2019.10.014 |
0.339 |
|
| 2020 |
Nixon SA, Dekan Z, Robinson SD, Guo S, Vetter I, Kotze AC, Alewood PF, King GF, Herzig V. It Takes Two: Dimerization Is Essential for the Broad-Spectrum Predatory and Defensive Activities of the Venom Peptide Mp1a from the Jack Jumper Ant . Biomedicines. 8. PMID 32629771 DOI: 10.3390/Biomedicines8070185 |
0.377 |
|
| 2020 |
Rupasinghe DB, Herzig V, Vetter I, Dekan Z, Gilchrist J, Bosmans F, Alewood PF, Lewis RJ, King GF. Mutational analysis of ProTx-I and the novel venom peptide Pe1b provide insight into residues responsible for selective inhibition of the analgesic drug target Na1.7. Biochemical Pharmacology. 114080. PMID 32511987 DOI: 10.1016/J.Bcp.2020.114080 |
0.363 |
|
| 2020 |
Muttenthaler M, Nevin ST, Inserra M, Lewis RJ, Adams DJ, Alewood P. On-resin strategy to label α-conotoxins: Cy5-RgIA, a potent α9α10 nicotinic acetylcholine receptor imaging probe. Australian Journal of Chemistry. 73: 327-333. PMID 32394983 DOI: 10.1071/Ch19456 |
0.52 |
|
| 2020 |
Yin K, Deuis JR, Dekan Z, Jin AH, Alewood PF, King GF, Herzig V, Vetter I. Addition of K22 Converts Spider Venom Peptide Pme2a from an Activator to an Inhibitor of Na1.7. Biomedicines. 8. PMID 32092883 DOI: 10.3390/Biomedicines8020037 |
0.422 |
|
| 2020 |
Himaya SWA, Rai SK, Pamfili G, Jin A, Alewood PF, Lewis RJ. Venomic Interrogation Reveals the Complexity of Conus striolatus Venom Australian Journal of Chemistry. 73: 357-365. DOI: 10.1071/Ch19588 |
0.363 |
|
| 2019 |
Foo CS, Jobichen C, Hassan-Puttaswamy V, Dekan Z, Tae HS, Bertrand D, Adams DJ, Alewood PF, Sivaraman J, Nirthanan S, Kini RM. Fulditoxin, representing a new class of dimeric snake toxins, defines novel pharmacology at nicotinic acetylcholine receptors. British Journal of Pharmacology. PMID 31877243 DOI: 10.1111/Bph.14954 |
0.465 |
|
| 2019 |
Dutt M, Giacomotto J, Ragnarsson L, Andersson Å, Brust A, Dekan Z, Alewood PF, Lewis RJ. The α-adrenoceptor inhibitor ρ-TIA facilitates net hunting in piscivorous Conus tulipa. Scientific Reports. 9: 17841. PMID 31780714 DOI: 10.1038/S41598-019-54186-Y |
0.383 |
|
| 2019 |
Jin AH, Muttenthaler M, Dutertre S, Himaya SWA, Kaas Q, Craik DJ, Lewis RJ, Alewood PF. Conotoxins: Chemistry and Biology. Chemical Reviews. PMID 31633928 DOI: 10.1021/Acs.Chemrev.9B00207 |
0.43 |
|
| 2019 |
Dekan Z, Sianati S, Yousuf A, Sutcliffe KJ, Gillis A, Mallet C, Singh P, Jin AH, Wang AM, Mohammadi SA, Stewart M, Ratnayake R, Fontaine F, Lacey E, Piggott AM, ... ... Alewood PF, et al. A tetrapeptide class of biased analgesics from an Australian fungus targets the µ-opioid receptor. Proceedings of the National Academy of Sciences of the United States of America. PMID 31611414 DOI: 10.1073/Pnas.1908662116 |
0.326 |
|
| 2019 |
Jin AH, Cristofori-Armstrong B, Rash LD, Román González SA, Espinosa RA, Lewis RJ, Alewood PF, Vetter I. Novel conorfamides from Conus austini venom modulate both nicotinic acetylcholine receptors and acid-sensing ion channels. Biochemical Pharmacology. PMID 31028742 DOI: 10.1016/J.Bcp.2019.04.025 |
0.427 |
|
| 2019 |
Jin AH, Dutertre S, Dutt M, Lavergne V, Jones A, Lewis RJ, Alewood PF. Transcriptomic-Proteomic Correlation in the Predation-Evoked Venom of the Cone Snail, . Marine Drugs. 17. PMID 30893765 DOI: 10.3390/Md17030177 |
0.333 |
|
| 2019 |
Ziegman R, Brust A, Jha P, Cardoso FC, Lewis RJ, Alewood PF. 'Messy' Processing of χ-conotoxin MrIA Generates Homologues with Reduced hNET Potency. Marine Drugs. 17. PMID 30875751 DOI: 10.3390/Md17030165 |
0.399 |
|
| 2019 |
Kakumanu R, Hodgson WC, Ravi R, Alagon A, Harris RJ, Brust A, Alewood PF, Kemp-Harper BK, Fry BG. Vampire Venom: Vasodilatory Mechanisms of Vampire Bat () Blood Feeding. Toxins. 11. PMID 30626071 DOI: 10.3390/Toxins11010026 |
0.372 |
|
| 2018 |
Sousa SR, McArthur JR, Brust A, Bhola RF, Rosengren KJ, Ragnarsson L, Dutertre S, Alewood PF, Christie MJ, Adams DJ, Vetter I, Lewis RJ. Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides. Scientific Reports. 8: 13397. PMID 30194442 DOI: 10.1038/S41598-018-31245-4 |
0.484 |
|
| 2018 |
Herzig V, de Araujo AD, Greenwood KP, Chin YK, Windley MJ, Chong Y, Muttenthaler M, Mobli M, Audsley N, Nicholson GM, Alewood PF, King GF. Evaluation of Chemical Strategies for Improving the Stability and Oral Toxicity of Insecticidal Peptides. Biomedicines. 6. PMID 30154370 DOI: 10.3390/Biomedicines6030090 |
0.403 |
|
| 2018 |
Ma L, Chin YKY, Dekan Z, Herzig V, Yuen Chow C, Heighway J, Wing Lam S, Guillemin GJ, Alewood PF, King GF. Novel venom-derived inhibitors of the human EAG channel, a putative antiepileptic drug target. Biochemical Pharmacology. PMID 30149017 DOI: 10.1016/J.Bcp.2018.08.038 |
0.42 |
|
| 2018 |
Madio B, Peigneur S, Chin YKY, Hamilton BR, Henriques ST, Smith JJ, Cristofori-Armstrong B, Dekan Z, Boughton BA, Alewood PF, Tytgat J, King GF, Undheim EAB. PHAB toxins: a unique family of predatory sea anemone toxins evolving via intra-gene concerted evolution defines a new peptide fold. Cellular and Molecular Life Sciences : Cmls. PMID 30109357 DOI: 10.1007/S00018-018-2897-6 |
0.424 |
|
| 2018 |
Ikonomopoulou MP, Fernandez-Rojo MA, Pineda SS, Cabezas-Sainz P, Winnen B, Morales RAV, Brust A, Sánchez L, Alewood PF, Ramm GA, Miles JJ, King GF. Gomesin inhibits melanoma growth by manipulating key signaling cascades that control cell death and proliferation. Scientific Reports. 8: 11519. PMID 30068931 DOI: 10.1038/s41598-018-29826-4 |
0.335 |
|
| 2018 |
Fernandez-Rojo MA, Deplazes E, Pineda SS, Brust A, Marth T, Wilhelm P, Martel N, Ramm GA, Mancera RL, Alewood PF, Woods GM, Belov K, Miles JJ, King GF, Ikonomopoulou MP. Gomesin peptides prevent proliferation and lead to the cell death of devil facial tumour disease cells. Cell Death Discovery. 4: 19. PMID 29531816 DOI: 10.1038/S41420-018-0030-0 |
0.347 |
|
| 2017 |
Muttenthaler M, Andersson Å, Vetter I, Menon R, Busnelli M, Ragnarsson L, Bergmayr C, Arrowsmith S, Deuis JR, Chiu HS, Palpant NJ, O'Brien M, Smith TJ, Wray S, Neumann ID, ... ... Alewood PF, et al. Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species. Science Signaling. 10. PMID 29208680 DOI: 10.1126/Scisignal.Aan3398 |
0.305 |
|
| 2017 |
Jin AH, Dekan Z, Smout MJ, Wilson D, Dutertre S, Vetter I, Lewis RJ, Loukas A, Daly NL, Alewood PF. Conotoxin Φ-MiXXVIIA from the new superfamily G2 employs a novel cysteine framework that mimics granulin and displays anti-apoptotic activity. Angewandte Chemie (International Ed. in English). PMID 28984021 DOI: 10.1002/Anie.201708927 |
0.449 |
|
| 2017 |
Sousa SR, Wingerd JS, Brust A, Bladen C, Ragnarsson L, Herzig V, Deuis JR, Dutertre S, Vetter I, Zamponi GW, King GF, Alewood PF, Lewis RJ. Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi. Plos One. 12: e0182848. PMID 28880874 DOI: 10.1371/Journal.Pone.0182848 |
0.372 |
|
| 2017 |
Deuis JR, Dekan Z, Wingerd JS, Smith JJ, Munasinghe NR, Bhola RF, Imlach WL, Herzig V, Armstrong DA, Rosengren KJ, Bosmans F, Waxman SG, Dib-Hajj SD, Escoubas P, Minett MS, ... ... Alewood PF, et al. Corrigendum: Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a. Scientific Reports. 7: 46816. PMID 28548111 DOI: 10.1038/Srep46816 |
0.34 |
|
| 2017 |
Cardoso FC, Dekan Z, Smith JJ, Deuis JR, Vetter I, Herzig V, Alewood PF, King GF, Lewis RJ. Modulatory features of the novel spider toxin μ-TRTX-Df1a isolated from the venom of the spider Davus fasciatus. British Journal of Pharmacology. PMID 28542706 DOI: 10.1111/Bph.13865 |
0.301 |
|
| 2017 |
Dekan Z, Heady SJ, Scanlon M, Baldo BA, Lee TH, Aguilar MI, Deuis JR, Vetter I, Elliott AG, Amado M, Cooper MA, Alewood D, Alewood PF. Δ-Myrtoxin-Mp1a is a helical heterodimer from the venom of the Jack Jumper ant with antimicrobial, membrane disrupting and nociceptive activities. Angewandte Chemie (International Ed. in English). PMID 28513074 DOI: 10.1002/Anie.201703360 |
0.373 |
|
| 2017 |
Wingerd JS, Mozar CA, Ussing CA, Murali SS, Chin YK, Cristofori-Armstrong B, Durek T, Gilchrist J, Vaughan CW, Bosmans F, Adams DJ, Lewis RJ, Alewood PF, Mobli M, Christie MJ, et al. The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity. Scientific Reports. 7: 974. PMID 28428547 DOI: 10.1038/S41598-017-01129-0 |
0.468 |
|
| 2017 |
Abraham N, Healy M, Ragnarsson L, Brust A, Alewood PF, Lewis RJ. Structural mechanisms for α-conotoxin activity at the human α3β4 nicotinic acetylcholine receptor. Scientific Reports. 7: 45466. PMID 28361878 DOI: 10.1038/Srep45466 |
0.358 |
|
| 2017 |
Di Giglio MG, Muttenthaler M, Harpsøe K, Liutkeviciute Z, Keov P, Eder T, Rattei T, Arrowsmith S, Wray S, Marek A, Elbert T, Alewood PF, Gloriam DE, Gruber CW. Development of a human vasopressin V1a-receptor antagonist from an evolutionary-related insect neuropeptide. Scientific Reports. 7: 41002. PMID 28145450 DOI: 10.1038/Srep41002 |
0.341 |
|
| 2017 |
Deuis JR, Dekan Z, Wingerd JS, Smith JJ, Munasinghe NR, Bhola RF, Imlach WL, Herzig V, Armstrong DA, Rosengren KJ, Bosmans F, Waxman SG, Dib-Hajj SD, Escoubas P, Minett MS, ... ... Alewood PF, et al. Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a. Scientific Reports. 7: 40883. PMID 28106092 DOI: 10.1038/Srep40883 |
0.367 |
|
| 2017 |
Abraham N, Healy M, Ragnarsson L, Brust A, Alewood PF, Lewis RJ. Structural mechanisms for alpha-conotoxin activity at the human alpha 3 beta 4 nicotinic acetylcholine receptor. Scientific Reports. 7: 45466-45466. DOI: 10.2210/Pdb5T90/Pdb |
0.319 |
|
| 2017 |
Alewood PF, Wade JD. Australasian Peptide Chemistry Australian Journal of Chemistry. 70: 125. DOI: 10.1071/Chv70N2_Fo |
0.4 |
|
| 2017 |
Wan J, Mobli M, Brust A, Muttenthaler M, Andersson Å, Ragnarsson L, Castro J, Vetter I, Huang JX, Nilsson M, Brierley SM, Cooper MA, Lewis RJ, Alewood PF. Synthesis of Multivalent [Lys8]-Oxytocin Dendrimers that Inhibit Visceral Nociceptive Responses Australian Journal of Chemistry. 70: 162. DOI: 10.1071/Ch16407 |
0.407 |
|
| 2016 |
Ikonomopoulou MP, Smith JJ, Herzig V, Pineda SS, Dziemborowicz S, Er SY, Durek T, Gilchrist J, Alewood PF, Nicholson GM, Bosmans F, King GF. Isolation of two insecticidal toxins from venom of the Australian theraphosid spider Coremiocnemis tropix. Toxicon : Official Journal of the International Society On Toxinology. PMID 27793656 DOI: 10.1016/J.Toxicon.2016.10.013 |
0.424 |
|
| 2016 |
Yang DC, Deuis JR, Dashevsky D, Dobson J, Jackson TN, Brust A, Xie B, Koludarov I, Debono J, Hendrikx I, Hodgson WC, Josh P, Nouwens A, Baillie GJ, Bruxner TJ, ... Alewood PF, et al. The Snake with the Scorpion's Sting: Novel Three-Finger Toxin Sodium Channel Activators from the Venom of the Long-Glanded Blue Coral Snake (Calliophis bivirgatus). Toxins. 8. PMID 27763551 DOI: 10.3390/Toxins8100303 |
0.405 |
|
| 2016 |
Touchard A, Brust A, Cardoso FC, Chin YK, Herzig V, Jin AH, Dejean A, Alewood PF, King GF, Orivel J, Escoubas P. Isolation and characterization of a structurally unique β-hairpin venom peptide from the predatory ant Anochetus emarginatus. Biochimica Et Biophysica Acta. PMID 27474999 DOI: 10.1016/J.Bbagen.2016.07.027 |
0.423 |
|
| 2016 |
Deuis JR, Dekan Z, Inserra MC, Lee TH, Aguilar MI, Craik DJ, Lewis RJ, Alewood PF, Mobli M, Schroeder CI, Henriques ST, Vetter I. Development of a μO-conotoxin Analogue with Improved Lipid Membrane Interactions and Potency for the Analgesic Target NaV1.8. The Journal of Biological Chemistry. PMID 27026701 DOI: 10.1074/Jbc.M116.721662 |
0.322 |
|
| 2016 |
Wan J, Alewood PF. Peptide-Decorated Dendrimers and Their Bioapplications. Angewandte Chemie (International Ed. in English). PMID 26990715 DOI: 10.1002/Anie.201508428 |
0.41 |
|
| 2016 |
Wan J, Brust A, Bhola RF, Jha P, Mobli M, Lewis RJ, Christie MJ, Alewood PF. Inhibition of the norepinephrine transporter by χ-conotoxin dendrimers. Journal of Peptide Science : An Official Publication of the European Peptide Society. PMID 26910400 DOI: 10.1002/Psc.2857 |
0.403 |
|
| 2016 |
Brust A, Croker DE, Colless B, Ragnarsson L, Andersson A, Jain K, Caraballo SG, Castro J, Brierley SM, Alewood PF, Lewis RJ. Conopeptide-derived κ-opioid agonists (conorphins): potent, selective and metabolic stable dynorphinA mimetics with anti-nociceptive properties. Journal of Medicinal Chemistry. PMID 26859603 DOI: 10.1021/Acs.Jmedchem.5B00911 |
0.324 |
|
| 2016 |
Wan J, Alewood PF. Mit Peptiden dekorierte Dendrimere und ihre biotechnologische Nutzung Angewandte Chemie. 128: 5208-5219. DOI: 10.1002/Ange.201508428 |
0.353 |
|
| 2015 |
Reeks T, Lavergne V, Sunagar K, Jones A, Undheim E, Dunstan N, Fry B, Alewood PF. Deep venomics of the Pseudonaja genus reveals inter- and intra-specific variation. Journal of Proteomics. PMID 26632978 DOI: 10.1016/J.Jprot.2015.11.019 |
0.389 |
|
| 2015 |
Prashanth JR, Dutertre S, Jin AH, Lavergne V, Hamilton B, Cardoso FC, Griffin J, Venter DJ, Alewood PF, Lewis RJ. The role of defensive ecological interactions in the evolution of conotoxins. Molecular Ecology. PMID 26614983 DOI: 10.1111/Mec.13504 |
0.361 |
|
| 2015 |
Jin AH, Vetter I, Himaya SW, Alewood PF, Lewis RJ, Dutertre S. Transcriptome and proteome of Conus planorbis identify the nicotinic receptors as primary target for the defensive venom. Proteomics. PMID 26506909 DOI: 10.1002/Pmic.201500220 |
0.341 |
|
| 2015 |
Himaya SW, Jin AH, Dutertre S, Giacomotto J, Mohialdeen H, Vetter I, Alewood PF, Lewis RJ. Comparative Venomics Reveals the Complex Prey Capture Strategy of the Piscivorous Cone Snail Conus catus. Journal of Proteome Research. 14: 4372-81. PMID 26322961 DOI: 10.1021/Acs.Jproteome.5B00630 |
0.42 |
|
| 2015 |
Deuis JR, Whately E, Brust A, Inserra MC, Asvadi NH, Lewis RJ, Alewood PF, Cabot PJ, Vetter I. Activation of κ Opioid Receptors in Cutaneous Nerve Endings by Conorphin-1, a Novel Subtype-Selective Conopeptide, Does Not Mediate Peripheral Analgesia. Acs Chemical Neuroscience. 6: 1751-8. PMID 26225903 DOI: 10.1021/Acschemneuro.5B00113 |
0.329 |
|
| 2015 |
Jin AH, Israel MR, Inserra MC, Smith JJ, Lewis RJ, Alewood PF, Vetter I, Dutertre S. δ-Conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snails. Proceedings. Biological Sciences / the Royal Society. 282. PMID 26156767 DOI: 10.1098/Rspb.2015.0817 |
0.371 |
|
| 2015 |
Lavergne V, Harliwong I, Jones A, Miller D, Taft RJ, Alewood PF. Optimized deep-targeted proteotranscriptomic profiling reveals unexplored Conus toxin diversity and novel cysteine frameworks. Proceedings of the National Academy of Sciences of the United States of America. 112: E3782-91. PMID 26150494 DOI: 10.1073/Pnas.1501334112 |
0.441 |
|
| 2015 |
Jouiaei M, Yanagihara AA, Madio B, Nevalainen TJ, Alewood PF, Fry BG. Ancient Venom Systems: A Review on Cnidaria Toxins. Toxins. 7: 2251-71. PMID 26094698 DOI: 10.3390/Toxins7062251 |
0.314 |
|
| 2015 |
Cardoso FC, Dekan Z, Rosengren KJ, Erickson A, Vetter I, Deuis JR, Herzig V, Alewood PF, King GF, Lewis RJ. Identification and Characterization of ProTx-III [μ-TRTX-Tp1a], a New Voltage-Gated Sodium Channel Inhibitor from Venom of the Tarantula Thrixopelma pruriens. Molecular Pharmacology. 88: 291-303. PMID 25979003 DOI: 10.1124/Mol.115.098178 |
0.412 |
|
| 2015 |
Ziegman R, Alewood P. Bioactive components in fish venoms. Toxins. 7: 1497-531. PMID 25941767 DOI: 10.3390/Toxins7051497 |
0.377 |
|
| 2015 |
Jouiaei M, Sunagar K, Federman Gross A, Scheib H, Alewood PF, Moran Y, Fry BG. Evolution of an ancient venom: recognition of a novel family of cnidarian toxins and the common evolutionary origin of sodium and potassium neurotoxins in sea anemone. Molecular Biology and Evolution. 32: 1598-610. PMID 25757852 DOI: 10.1093/Molbev/Msv050 |
0.378 |
|
| 2015 |
Reeks T, Jones A, Brust A, Sridharan S, Corcilius L, Wilkinson BL, Thaysen-Andersen M, Payne RJ, Kini RM, Daly NL, Alewood PF. A defined α-helix in the bifunctional O-glycosylated natriuretic peptide TcNPa from the venom of Tropidechis carinatus. Angewandte Chemie (International Ed. in English). 54: 4828-31. PMID 25735823 DOI: 10.1002/Anie.201411914 |
0.418 |
|
| 2015 |
Wan J, Huang JX, Vetter I, Mobli M, Lawson J, Tae HS, Abraham N, Paul B, Cooper MA, Adams DJ, Lewis RJ, Alewood PF. α-Conotoxin dendrimers have enhanced potency and selectivity for homomeric nicotinic acetylcholine receptors. Journal of the American Chemical Society. 137: 3209-12. PMID 25710197 DOI: 10.1021/Jacs.5B00244 |
0.465 |
|
| 2015 |
Reeks TA, Fry BG, Alewood PF. Privileged frameworks from snake venom Cellular and Molecular Life Sciences. 72: 1939-1958. PMID 25693678 DOI: 10.1007/S00018-015-1844-Z |
0.399 |
|
| 2015 |
Mueller A, Starobova H, Inserra MC, Jin AH, Deuis JR, Dutertre S, Lewis RJ, Alewood PF, Daly NL, Vetter I. α-Conotoxin MrIC is a biased agonist at α7 nicotinic acetylcholine receptors. Biochemical Pharmacology. 94: 155-63. PMID 25646788 DOI: 10.1016/J.Bcp.2015.01.011 |
0.338 |
|
| 2015 |
Gori A, Wang CI, Harvey PJ, Rosengren KJ, Bhola RF, Gelmi ML, Longhi R, Christie MJ, Lewis RJ, Alewood PF, Brust A. Stabilization of the cysteine-rich conotoxin MrIA by using a 1,2,3-triazole as a disulfide bond mimetic. Angewandte Chemie (International Ed. in English). 54: 1361-4. PMID 25483297 DOI: 10.1002/Anie.201409678 |
0.336 |
|
| 2014 |
Prashanth JR, Brust A, Jin AH, Alewood PF, Dutertre S, Lewis RJ. Cone snail venomics: from novel biology to novel therapeutics. Future Medicinal Chemistry. 6: 1659-75. PMID 25406006 DOI: 10.4155/Fmc.14.99 |
0.345 |
|
| 2014 |
Jensen JE, Cristofori-Armstrong B, Anangi R, Rosengren KJ, Lau CH, Mobli M, Brust A, Alewood PF, King GF, Rash LD. Understanding the molecular basis of toxin promiscuity: the analgesic sea anemone peptide APETx2 interacts with acid-sensing ion channel 3 and hERG channels via overlapping pharmacophores. Journal of Medicinal Chemistry. 57: 9195-203. PMID 25337890 DOI: 10.1021/Jm501400P |
0.409 |
|
| 2014 |
Hopping G, Wang CI, Hogg RC, Nevin ST, Lewis RJ, Adams DJ, Alewood PF. Hydrophobic residues at position 10 of α-conotoxin PnIA influence subtype selectivity between α7 and α3β2 neuronal nicotinic acetylcholine receptors. Biochemical Pharmacology. 91: 534-42. PMID 25101833 DOI: 10.1016/J.Bcp.2014.07.025 |
0.477 |
|
| 2014 |
Wang CI, Reeks T, Vetter I, Vergara I, Kovtun O, Lewis RJ, Alewood PF, Durek T. Isolation and structural and pharmacological characterization of α-elapitoxin-Dpp2d, an amidated three finger toxin from black mamba venom. Biochemistry. 53: 3758-66. PMID 24867092 DOI: 10.1021/Bi5004475 |
0.379 |
|
| 2014 |
Akondi KB, Muttenthaler M, Dutertre S, Kaas Q, Craik DJ, Lewis RJ, Alewood PF. Discovery, synthesis, and structure-activity relationships of conotoxins. Chemical Reviews. 114: 5815-47. PMID 24720541 DOI: 10.1021/Cr400401E |
0.347 |
|
| 2014 |
Dutertre S, Jin AH, Vetter I, Hamilton B, Sunagar K, Lavergne V, Dutertre V, Fry BG, Antunes A, Venter DJ, Alewood PF, Lewis RJ. Evolution of separate predation- and defence-evoked venoms in carnivorous cone snails. Nature Communications. 5: 3521. PMID 24662800 DOI: 10.1038/Ncomms4521 |
0.315 |
|
| 2014 |
Berecki G, Daly NL, Huang YH, Vink S, Craik DJ, Alewood PF, Adams DJ. Effects of arginine 10 to lysine substitution on ω-conotoxin CVIE and CVIF block of Cav2.2 channels. British Journal of Pharmacology. 171: 3313-27. PMID 24628243 DOI: 10.1111/Bph.12686 |
0.422 |
|
| 2014 |
Dekan Z, Mobli M, Pennington MW, Fung E, Nemeth E, Alewood PF. Total synthesis of human hepcidin through regioselective disulfide-bond formation by using the safety-catch cysteine protecting group 4,4'-dimethylsulfinylbenzhydryl. Angewandte Chemie (International Ed. in English). 53: 2931-4. PMID 24604812 DOI: 10.1002/Anie.201310103 |
0.358 |
|
| 2014 |
Brust A, Schroeder CI, Alewood PF. High-throughput synthesis of peptide α-thioesters: a safety catch linker approach enabling parallel hydrogen fluoride cleavage. Chemmedchem. 9: 1038-46. PMID 24591329 DOI: 10.1002/Cmdc.201300524 |
0.432 |
|
| 2014 |
Klint JK, Berecki G, Durek T, Mobli M, Knapp O, King GF, Adams DJ, Alewood PF, Rash LD. Isolation, synthesis and characterization of ω-TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type Cav channels. Biochemical Pharmacology. 89: 276-86. PMID 24561180 DOI: 10.1016/J.Bcp.2014.02.008 |
0.524 |
|
| 2014 |
Gui J, Liu B, Cao G, Lipchik AM, Perez M, Dekan Z, Mobli M, Daly NL, Alewood PF, Parker LL, King GF, Zhou Y, Jordt SE, Nitabach MN. A tarantula-venom peptide antagonizes the TRPA1 nociceptor ion channel by binding to the S1-S4 gating domain. Current Biology : Cb. 24: 473-83. PMID 24530065 DOI: 10.1016/J.Cub.2014.01.013 |
0.403 |
|
| 2014 |
de Araujo AD, Mobli M, Castro J, Harrington AM, Vetter I, Dekan Z, Muttenthaler M, Wan J, Lewis RJ, King GF, Brierley SM, Alewood PF. Selenoether oxytocin analogues have analgesic properties in a mouse model of chronic abdominal pain. Nature Communications. 5: 3165. PMID 24476666 DOI: 10.1038/Ncomms4165 |
0.406 |
|
| 2014 |
Jin AH, Vetter I, Dutertre S, Abraham N, Emidio NB, Inserra M, Murali SS, Christie MJ, Alewood PF, Lewis RJ. MrIC, a novel α-conotoxin agonist in the presence of PNU at endogenous α7 nicotinic acetylcholine receptors. Biochemistry. 53: 1-3. PMID 24351107 DOI: 10.1021/Bi400882S |
0.355 |
|
| 2014 |
Schroeder CI, Rash LD, Vila-Farrés X, Rosengren KJ, Mobli M, King GF, Alewood PF, Craik DJ, Durek T. Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2. Angewandte Chemie (International Ed. in English). 53: 1017-20. PMID 24323786 DOI: 10.1002/Anie.201308898 |
0.445 |
|
| 2014 |
Akondi KB, Lewis RJ, Alewood PF. Re-engineering the μ-conotoxin SIIIA scaffold. Biopolymers. 101: 347-54. PMID 23913763 DOI: 10.1002/Bip.22368 |
0.343 |
|
| 2014 |
Gori A, Wang CA, Harvey PJ, Rosengren KJ, Bhola RF, Gelmi ML, Longhi R, Christie MJ, Lewis RJ, Alewood PF, Brust A. Stabilisierung eines cysteinreichen Kegelschneckentoxins, MrIA, in Form eines 1,2,3-Triazol-Disulfidbrückenmimetikums Angewandte Chemie. 127: 1378-1381. DOI: 10.1002/Ange.201409678 |
0.322 |
|
| 2013 |
Lavergne V, Dutertre S, Jin AH, Lewis RJ, Taft RJ, Alewood PF. Systematic interrogation of the Conus marmoreus venom duct transcriptome with ConoSorter reveals 158 novel conotoxins and 13 new gene superfamilies. Bmc Genomics. 14: 708. PMID 24131469 DOI: 10.1186/1471-2164-14-708 |
0.31 |
|
| 2013 |
Brust A, Wang CI, Daly NL, Kennerly J, Sadeghi M, Christie MJ, Lewis RJ, Mobli M, Alewood PF. Vicinal disulfide constrained cyclic peptidomimetics: a turn mimetic scaffold targeting the norepinephrine transporter. Angewandte Chemie (International Ed. in English). 52: 12020-3. PMID 24115503 DOI: 10.1002/Anie.201304660 |
0.421 |
|
| 2013 |
Grishin AA, Cuny H, Hung A, Clark RJ, Brust A, Akondi K, Alewood PF, Craik DJ, Adams DJ. Identifying key amino acid residues that affect α-conotoxin AuIB inhibition of α3β4 nicotinic acetylcholine receptors. The Journal of Biological Chemistry. 288: 34428-42. PMID 24100032 DOI: 10.1074/Jbc.M113.512582 |
0.509 |
|
| 2013 |
Jin AH, Dutertre S, Kaas Q, Lavergne V, Kubala P, Lewis RJ, Alewood PF. Transcriptomic messiness in the venom duct of Conus miles contributes to conotoxin diversity. Molecular & Cellular Proteomics : McP. 12: 3824-33. PMID 24043424 DOI: 10.1074/Mcp.M113.030353 |
0.421 |
|
| 2013 |
Inserra MC, Kompella SN, Vetter I, Brust A, Daly NL, Cuny H, Craik DJ, Alewood PF, Adams DJ, Lewis RJ. Isolation and characterization of α-conotoxin LsIA with potent activity at nicotinic acetylcholine receptors. Biochemical Pharmacology. 86: 791-9. PMID 23924607 DOI: 10.1016/J.Bcp.2013.07.016 |
0.509 |
|
| 2013 |
Ruder T, Ali SA, Ormerod K, Brust A, Roymanchadi ML, Ventura S, Undheim EA, Jackson TN, Mercier AJ, King GF, Alewood PF, Fry BG. Functional characterization on invertebrate and vertebrate tissues of tachykinin peptides from octopus venoms. Peptides. 47: 71-6. PMID 23850991 DOI: 10.1016/J.Peptides.2013.07.002 |
0.429 |
|
| 2013 |
Le TT, Deeth HC, Bhandari B, Alewood PF, Holland JW. Quantification of lactosylation of whey proteins in stored milk powder using multiple reaction monitoring. Food Chemistry. 141: 1203-10. PMID 23790905 DOI: 10.1016/J.Foodchem.2013.03.073 |
0.328 |
|
| 2013 |
Smith JJ, Vetter I, Lewis RJ, Peigneur S, Tytgat J, Lam A, Gallant EM, Beard NA, Alewood PF, Dulhunty AF. Multiple actions of phi-LITX-Lw1a on ryanodine receptors reveal a functional link between scorpion DDH and ICK toxins. Proceedings of the National Academy of Sciences of the United States of America. 110: 8906-11. PMID 23671114 DOI: 10.1073/Pnas.1214062110 |
0.367 |
|
| 2013 |
Ghassemian A, Vila-Farrés X, Alewood PF, Durek T. Solid phase synthesis of peptide-selenoesters. Bioorganic & Medicinal Chemistry. 21: 3473-8. PMID 23608106 DOI: 10.1016/J.Bmc.2013.03.076 |
0.427 |
|
| 2013 |
Durek T, Vetter I, Wang CI, Motin L, Knapp O, Adams DJ, Lewis RJ, Alewood PF. Chemical engineering and structural and pharmacological characterization of the α-scorpion toxin OD1. Acs Chemical Biology. 8: 1215-22. PMID 23527544 DOI: 10.1021/Cb400012K |
0.517 |
|
| 2013 |
Smith JJ, Herzig V, King GF, Alewood PF. The insecticidal potential of venom peptides. Cellular and Molecular Life Sciences : Cmls. 70: 3665-93. PMID 23525661 DOI: 10.1007/S00018-013-1315-3 |
0.419 |
|
| 2013 |
Ghassemian A, Wang CI, Yau MK, Reid RC, Lewis RJ, Fairlie DP, Alewood PF, Durek T. Efficient chemical synthesis of human complement protein C3a. Chemical Communications (Cambridge, England). 49: 2356-8. PMID 23407800 DOI: 10.1039/C3Cc40537K |
0.308 |
|
| 2013 |
Brust A, Sunagar K, Undheim EA, Vetter I, Yang DC, Yang DC, Casewell NR, Jackson TN, Koludarov I, Alewood PF, Hodgson WC, Lewis RJ, King GF, Antunes A, Hendrikx I, et al. Differential evolution and neofunctionalization of snake venom metalloprotease domains. Molecular & Cellular Proteomics : McP. 12: 651-63. PMID 23242553 DOI: 10.1074/Mcp.M112.023135 |
0.383 |
|
| 2013 |
Dutertre S, Jin AH, Kaas Q, Jones A, Alewood PF, Lewis RJ. Deep venomics reveals the mechanism for expanded peptide diversity in cone snail venom. Molecular & Cellular Proteomics : McP. 12: 312-29. PMID 23152539 DOI: 10.1074/Mcp.M112.021469 |
0.398 |
|
| 2013 |
Vink S, Alewood PF. Targeting voltage-gated calcium channels: developments in peptide and small-molecule inhibitors for the treatment of neuropathic pain. British Journal of Pharmacology. 167: 970-89. PMID 22725651 DOI: 10.1111/J.1476-5381.2012.02082.X |
0.351 |
|
| 2012 |
Schroeder CI, Nielsen KJ, Adams DA, Loughnan M, Thomas L, Alewood PF, Lewis RJ, Craik DJ. Effects of Lys2 to Ala2 substitutions on the structure and potency of ω-conotoxins MVIIA and CVID. Biopolymers. 98: 345-56. PMID 23193599 DOI: 10.1002/Bip.22031 |
0.372 |
|
| 2012 |
de Araujo AD, Mobli M, King GF, Alewood PF. Cyclization of peptides by using selenolanthionine bridges. Angewandte Chemie (International Ed. in English). 51: 10298-302. PMID 22991244 DOI: 10.1002/Anie.201204229 |
0.413 |
|
| 2012 |
Jensen JE, Mobli M, Brust A, Alewood PF, King GF, Rash LD. Cyclisation increases the stability of the sea anemone peptide APETx2 but decreases its activity at acid-sensing ion channel 3. Marine Drugs. 10: 1511-27. PMID 22851922 DOI: 10.3390/Md10071511 |
0.438 |
|
| 2012 |
Lavergne V, Taft RJ, Alewood PF. Cysteine-rich mini-proteins in human biology. Current Topics in Medicinal Chemistry. 12: 1514-33. PMID 22827521 DOI: 10.2174/156802612802652411 |
0.353 |
|
| 2012 |
Schroeder CI, Adams D, Thomas L, Alewood PF, Lewis RJ. N- and C-terminal extensions of μ-conotoxins increase potency and selectivity for neuronal sodium channels. Biopolymers. 98: 161-5. PMID 22733528 DOI: 10.1002/Bip.22032 |
0.406 |
|
| 2012 |
Vetter I, Dekan Z, Knapp O, Adams DJ, Alewood PF, Lewis RJ. Isolation, characterization and total regioselective synthesis of the novel μO-conotoxin MfVIA from Conus magnificus that targets voltage-gated sodium channels. Biochemical Pharmacology. 84: 540-8. PMID 22609441 DOI: 10.1016/J.Bcp.2012.05.008 |
0.481 |
|
| 2012 |
Dekan Z, Wang CI, Andrews RK, Lewis RJ, Alewood PF. Conotoxin engineering: dual pharmacophoric noradrenaline transport inhibitor/integrin binding peptide with improved stability. Organic & Biomolecular Chemistry. 10: 5791-4. PMID 22581211 DOI: 10.1039/C2Ob25133G |
0.403 |
|
| 2012 |
Beaumont KA, Smit DJ, Liu YY, Chai E, Patel MP, Millhauser GL, Smith JJ, Alewood PF, Sturm RA. Melanocortin-1 receptor-mediated signalling pathways activated by NDP-MSH and HBD3 ligands. Pigment Cell & Melanoma Research. 25: 370-4. PMID 22364200 DOI: 10.1111/J.1755-148X.2012.00990.X |
0.323 |
|
| 2012 |
Napier IA, Klimis H, Rycroft BK, Jin AH, Alewood PF, Motin L, Adams DJ, Christie MJ. Intrathecal α-conotoxins Vc1.1, AuIB and MII acting on distinct nicotinic receptor subtypes reverse signs of neuropathic pain. Neuropharmacology. 62: 2202-7. PMID 22306793 DOI: 10.1016/J.Neuropharm.2012.01.016 |
0.467 |
|
| 2012 |
Hjørringgaard CU, Brust A, Alewood PF. Evaluation of COMU as a coupling reagent for in situ neutralization Boc solid phase peptide synthesis. Journal of Peptide Science : An Official Publication of the European Peptide Society. 18: 199-207. PMID 22252935 DOI: 10.1002/Psc.1438 |
0.348 |
|
| 2012 |
Franco A, Kompella SN, Akondi KB, Melaun C, Daly NL, Luetje CW, Alewood PF, Craik DJ, Adams DJ, Marà F. RegIIA: an α4/7-conotoxin from the venom of Conus regius that potently blocks α3β4 nAChRs. Biochemical Pharmacology. 83: 419-26. PMID 22108175 DOI: 10.1016/J.Bcp.2011.11.006 |
0.507 |
|
| 2012 |
Franco A, Heighinian M, Mejia M, McCall J, Nag S, Akondi K, Melaun C, Daly N, Luetje CW, Alewood PF, Craik DJ, Godenschwege T, Adams DJ, Marí F. 105. Discovery, Characterization, and Functional Implications of Conotoxins from Cone Snails Species of the Americas Toxicon. 60: 148. DOI: 10.1016/J.Toxicon.2012.04.106 |
0.383 |
|
| 2012 |
Dutertre S, Jin A, Alewood PF, Lewis RJ. 99. The Venom of Conus geographus Revisited Toxicon. 60: 145. DOI: 10.1016/J.Toxicon.2012.04.100 |
0.343 |
|
| 2011 |
Muttenthaler M, Akondi KB, Alewood PF. Structure-activity studies on alpha-conotoxins. Current Pharmaceutical Design. 17: 4226-41. PMID 22204424 DOI: 10.2174/138161211798999384 |
0.47 |
|
| 2011 |
de Araujo AD, Christensen C, Buchardt J, Kent SB, Alewood PF. Synthesis of tripeptide mimetics based on dihydroquinolinone and benzoxazinone scaffolds. Chemistry (Weinheim An Der Bergstrasse, Germany). 17: 13983-6. PMID 22084036 DOI: 10.1002/Chem.201102732 |
0.326 |
|
| 2011 |
Durek T, Alewood PF. Preformed selenoesters enable rapid native chemical ligation at intractable sites. Angewandte Chemie (International Ed. in English). 50: 12042-5. PMID 21997950 DOI: 10.1002/Anie.201105512 |
0.412 |
|
| 2011 |
Dekan Z, Vetter I, Daly NL, Craik DJ, Lewis RJ, Alewood PF. α-Conotoxin ImI incorporating stable cystathionine bridges maintains full potency and identical three-dimensional structure. Journal of the American Chemical Society. 133: 15866-9. PMID 21899353 DOI: 10.1021/Ja206408Q |
0.411 |
|
| 2011 |
Smith JJ, Hill JM, Little MJ, Nicholson GM, King GF, Alewood PF. Unique scorpion toxin with a putative ancestral fold provides insight into evolution of the inhibitor cystine knot motif. Proceedings of the National Academy of Sciences of the United States of America. 108: 10478-83. PMID 21670253 DOI: 10.1073/Pnas.1103501108 |
0.444 |
|
| 2011 |
de Araujo AD, Callaghan B, Nevin ST, Daly NL, Craik DJ, Moretta M, Hopping G, Christie MJ, Adams DJ, Alewood PF. Total synthesis of the analgesic conotoxin MrVIB through selenocysteine-assisted folding. Angewandte Chemie (International Ed. in English). 50: 6527-9. PMID 21630402 DOI: 10.1002/Anie.201101642 |
0.502 |
|
| 2011 |
Wijffels G, Johnson WM, Oakley AJ, Turner K, Epa VC, Briscoe SJ, Polley M, Liepa AJ, Hofmann A, Buchardt J, Christensen C, Prosselkov P, Dalrymple BP, Alewood PF, Jennings PA, et al. Binding inhibitors of the bacterial sliding clamp by design. Journal of Medicinal Chemistry. 54: 4831-8. PMID 21604761 DOI: 10.1021/Jm2004333 |
0.327 |
|
| 2011 |
Rash LD, Morales RA, Vink S, Alewood PF. De novo sequencing of peptides from the parotid secretion of the cane toad, Bufo marinus (Rhinella marina). Toxicon : Official Journal of the International Society On Toxinology. 57: 208-16. PMID 21115026 DOI: 10.1016/J.Toxicon.2010.11.012 |
0.418 |
|
| 2011 |
Klimis H, Adams DJ, Callaghan B, Nevin S, Alewood PF, Vaughan CW, Mozar CA, Christie MJ. A novel mechanism of inhibition of high-voltage activated calcium channels by α-conotoxins contributes to relief of nerve injury-induced neuropathic pain. Pain. 152: 259-66. PMID 20889259 DOI: 10.1016/J.Pain.2010.09.007 |
0.454 |
|
| 2011 |
Berecki G, Motin L, Haythornthwaite A, Vink S, Bansal P, Drinkwater R, Wang CI, Moretta M, Lewis J, Alewood PF, Christie MJ, Adams DJ. Analgesic ω-conotoxins CVIE and CVIF selectively and voltage-dependently block recombinant and native N-type calcium channels (Molecular Pharmacology (2010) 77, (139-148)) Molecular Pharmacology. 80: 356. DOI: 10.1124/Mol.80.2.356 |
0.428 |
|
| 2011 |
Adams D, Grishin A, Hung A, Clark R, Akondi K, Alewood P, Craik D. Scanning mutagenesis of α-conotoxin AuIB reveals a critical residue for activity at the α3β4 nicotinic acetylcholine receptor Biochemical Pharmacology. 82: 1028. DOI: 10.1016/J.Bcp.2011.07.017 |
0.444 |
|
| 2010 |
Vink S, Jin AH, Poth KJ, Head GA, Alewood PF. Natriuretic peptide drug leads from snake venom. Toxicon : Official Journal of the International Society On Toxinology. 59: 434-45. PMID 21147145 DOI: 10.1016/J.Toxicon.2010.12.001 |
0.406 |
|
| 2010 |
Alewood D, Hopping G, Brust A, Reid RC, Alewood PF. Benzhydrylamine linker grafting: a strategy for the improved synthesis of C-terminal peptide amides. Journal of Peptide Science : An Official Publication of the European Peptide Society. 16: 551-7. PMID 20862722 DOI: 10.1002/Psc.1248 |
0.399 |
|
| 2010 |
Morales RA, Daly NL, Vetter I, Mobli M, Napier IA, Craik DJ, Lewis RJ, Christie MJ, King GF, Alewood PF, Durek T. Chemical synthesis and structure of the prokineticin Bv8. Chembiochem : a European Journal of Chemical Biology. 11: 1882-8. PMID 20677202 DOI: 10.1002/Cbic.201000330 |
0.408 |
|
| 2010 |
Grishin AA, Wang CI, Muttenthaler M, Alewood PF, Lewis RJ, Adams DJ. Alpha-conotoxin AuIB isomers exhibit distinct inhibitory mechanisms and differential sensitivity to stoichiometry of alpha3beta4 nicotinic acetylcholine receptors. The Journal of Biological Chemistry. 285: 22254-63. PMID 20466726 DOI: 10.1074/Jbc.M110.111880 |
0.471 |
|
| 2010 |
Muttenthaler M, Nevin ST, Grishin AA, Ngo ST, Choy PT, Daly NL, Hu SH, Armishaw CJ, Wang CI, Lewis RJ, Martin JL, Noakes PG, Craik DJ, Adams DJ, Alewood PF. Solving the alpha-conotoxin folding problem: efficient selenium-directed on-resin generation of more potent and stable nicotinic acetylcholine receptor antagonists. Journal of the American Chemical Society. 132: 3514-22. PMID 20163143 DOI: 10.1021/Ja910602H |
0.485 |
|
| 2010 |
Luo S, Akondi KB, Zhangsun D, Wu Y, Zhu X, Hu Y, Christensen S, Dowell C, Daly NL, Craik DJ, Wang CIA, Lewis RJ, Alewood PF, McIntosh JM. Atypical α-conotoxin LtIA from Conus litteratus targets a novel microsite of the α3β2 nicotinic receptor Journal of Biological Chemistry. 285: 12355-12366. PMID 20145249 DOI: 10.1074/Jbc.M109.079012 |
0.362 |
|
| 2010 |
Armishaw CJ, Dutton JL, Craik DJ, Alewood PF. Establishing regiocontrol of disulfide bond isomers of alpha-conotoxin ImI via the synthesis of N-to-C cyclic analogs. Biopolymers. 94: 307-13. PMID 20013812 DOI: 10.1002/Bip.21360 |
0.378 |
|
| 2010 |
Berecki G, Motin L, Haythornthwaite A, Vink S, Bansal P, Drinkwater R, Wang CI, Moretta M, Lewis RJ, Alewood PF, Christie MJ, Adams DJ. Analgesic (omega)-conotoxins CVIE and CVIF selectively and voltage-dependently block recombinant and native N-type calcium channels. Molecular Pharmacology. 77: 139-48. PMID 19892914 DOI: 10.1124/Mol.109.058834 |
0.484 |
|
| 2009 |
Brust A, Palant E, Croker DE, Colless B, Drinkwater R, Patterson B, Schroeder CI, Wilson D, Nielsen CK, Smith MT, Alewood D, Alewood PF, Lewis RJ. chi-Conopeptide pharmacophore development: toward a novel class of norepinephrine transporter inhibitor (Xen2174) for pain. Journal of Medicinal Chemistry. 52: 6991-7002. PMID 19860431 DOI: 10.1021/Jm9003413 |
0.346 |
|
| 2009 |
Vernall AJ, Cassidy P, Alewood PF. A single alpha-helical turn stabilized by replacement of an internal hydrogen bond with a covalent ethylene bridge. Angewandte Chemie (International Ed. in English). 48: 5675-8. PMID 19562809 DOI: 10.1002/Anie.200901059 |
0.31 |
|
| 2009 |
Ueberheide BM, Fenyö D, Alewood PF, Chait BT. Rapid sensitive analysis of cysteine rich peptide venom components. Proceedings of the National Academy of Sciences of the United States of America. 106: 6910-5. PMID 19380747 DOI: 10.1073/Pnas.0900745106 |
0.441 |
|
| 2009 |
Jensen JE, Durek T, Alewood PF, Adams DJ, King GF, Rash LD. Chemical synthesis and folding of APETx2, a potent and selective inhibitor of acid sensing ion channel 3 Toxicon. 54: 56-61. PMID 19306891 DOI: 10.1016/J.Toxicon.2009.03.014 |
0.514 |
|
| 2009 |
Pages G, Torres AM, Ju P, Bansal PS, Alewood PF, Kuchel PW, Vandenberg JI. Structure of the pore-helix of the hERG K(+) channel. European Biophysics Journal : Ebj. 39: 111-20. PMID 19305991 DOI: 10.1007/S00249-009-0433-1 |
0.424 |
|
| 2009 |
Millard EL, Nevin ST, Loughnan ML, Nicke A, Clark RJ, Alewood PF, Lewis RJ, Adams DJ, Craik DJ, Daly NL. Inhibition of neuronal nicotinic acetylcholine receptor subtypes by alpha-Conotoxin GID and analogues. The Journal of Biological Chemistry. 284: 4944-51. PMID 19098004 DOI: 10.1074/Jbc.M804950200 |
0.507 |
|
| 2009 |
Hopping G, Lewis RJ, Alewood PF. Rapid access to ω-conotoxin chimeras using native chemical ligation Australian Journal of Chemistry. 62: 1333-1338. DOI: 10.1071/Ch09216 |
0.424 |
|
| 2008 |
Muttenthaler M, Alewood PF. Selenopeptide chemistry. Journal of Peptide Science : An Official Publication of the European Peptide Society. 14: 1223-39. PMID 18951416 DOI: 10.1002/psc.1075 |
0.312 |
|
| 2008 |
Poth AG, Deeth HC, Alewood PF, Holland JW. Analysis of the human casein phosphoproteome by 2-D electrophoresis and MALDI-TOF/TOF MS reveals new phosphoforms Journal of Proteome Research. 7: 5017-5027. PMID 18847231 DOI: 10.1021/Pr800387S |
0.305 |
|
| 2008 |
Jin AH, Daly NL, Nevin ST, Wang CI, Dutertre S, Lewis RJ, Adams DJ, Craik DJ, Alewood PF. Molecular engineering of conotoxins: the importance of loop size to alpha-conotoxin structure and function. Journal of Medicinal Chemistry. 51: 5575-84. PMID 18754612 DOI: 10.1021/Jm800278K |
0.465 |
|
| 2008 |
Holland JW, Deeth HC, Alewood PF. Analysis of disulphide linkages in bovine κ-casein oligomers using two-dimensional electrophoresis Electrophoresis. 29: 2402-2410. PMID 18548457 DOI: 10.1002/Elps.200700840 |
0.313 |
|
| 2008 |
Schroeder CI, Ekberg J, Nielsen KJ, Adams D, Loughnan ML, Thomas L, Adams DJ, Alewood PF, Lewis RJ. Neuronally micro-conotoxins from Conus striatus utilize an alpha-helical motif to target mammalian sodium channels. The Journal of Biological Chemistry. 283: 21621-8. PMID 18522941 DOI: 10.1074/Jbc.M802852200 |
0.497 |
|
| 2008 |
Imperial JS, Chen P, Sporning A, Terlau H, Daly NL, Craik DJ, Alewood PF, Olivera BM. Tyrosine-rich conopeptides affect voltage-gated K+ channels. The Journal of Biological Chemistry. 283: 23026-32. PMID 18505731 DOI: 10.1074/Jbc.M800084200 |
0.447 |
|
| 2008 |
Tyndall JD, Pattenden LK, Reid RC, Hu SH, Alewood D, Alewood PF, Walsh T, Fairlie DP, Martin JL. Crystal structures of highly constrained substrate and hydrolysis products bound to HIV-1 protease. Implications for the catalytic mechanism. Biochemistry. 47: 3736-44. PMID 18311928 DOI: 10.1021/Bi7023157 |
0.341 |
|
| 2008 |
Yan WX, Armishaw C, Goyette J, Yang Z, Cai H, Alewood P, Geczy CL. Mast cell and monocyte recruitment by S100A12 and its hinge domain. The Journal of Biological Chemistry. 283: 13035-43. PMID 18292089 DOI: 10.1074/Jbc.M710388200 |
0.321 |
|
| 2008 |
Dutertre S, Croker D, Daly NL, Andersson A, Muttenthaler M, Lumsden NG, Craik DJ, Alewood PF, Guillon G, Lewis RJ. Conopressin-T from Conus tulipa reveals an antagonist switch in vasopressin-like peptides. The Journal of Biological Chemistry. 283: 7100-8. PMID 18174156 DOI: 10.1074/Jbc.M706477200 |
0.36 |
|
| 2007 |
Dutertre S, Ulens C, Büttner R, Fish A, van Elk R, Kendel Y, Hopping G, Alewood PF, Schroeder C, Nicke A, Smit AB, Sixma TK, Lewis RJ. AChBP-targeted alpha-conotoxin correlates distinct binding orientations with nAChR subtype selectivity. The Embo Journal. 26: 3858-67. PMID 17660751 DOI: 10.1038/Sj.Emboj.7601785 |
0.362 |
|
| 2007 |
Blanchfield JT, Gallagher OP, Cros C, Lewis RJ, Alewood PF, Toth I. Oral absorption and in vivo biodistribution of alpha-conotoxin MII and a lipidic analogue. Biochemical and Biophysical Research Communications. 361: 97-102. PMID 17640618 DOI: 10.1016/J.Bbrc.2007.06.138 |
0.408 |
|
| 2007 |
Jin AH, Brandstaetter H, Nevin ST, Tan CC, Clark RJ, Adams DJ, Alewood PF, Craik DJ, Daly NL. Structure of alpha-conotoxin BuIA: influences of disulfide connectivity on structural dynamics. Bmc Structural Biology. 7: 28. PMID 17445276 DOI: 10.1186/1472-6807-7-28 |
0.457 |
|
| 2007 |
Lewis RJ, Schroeder CI, Ekberg J, Nielsen KJ, Loughnan M, Thomas L, Adams DA, Drinkwater R, Adams DJ, Alewood PF. Isolation and structure-activity of mu-conotoxin TIIIA, a potent inhibitor of tetrodotoxin-sensitive voltage-gated sodium channels. Molecular Pharmacology. 71: 676-85. PMID 17142296 DOI: 10.1124/Mol.106.028225 |
0.527 |
|
| 2007 |
Nair DG, Fry BG, Alewood P, Kumar PP, Kini RM. Antimicrobial activity of omwaprin, a new member of the waprin family of snake venom proteins. The Biochemical Journal. 402: 93-104. PMID 17044815 DOI: 10.1042/Bj20060318 |
0.331 |
|
| 2007 |
Torres AM, Tsampazi M, Kennett EC, Belov K, Geraghty DP, Bansal PS, Alewood PF, Kuchel PW. Characterization and isolation of L-to-D-amino-acid-residue isomerase from platypus venom. Amino Acids. 32: 63-8. PMID 16729187 DOI: 10.1007/S00726-006-0346-6 |
0.395 |
|
| 2007 |
Dekan Z, Paczkowski FA, Lewis RJ, Alewood PF. Synthesis and In vitro Biological Activity of Cyclic Lipophilic χ-Conotoxin MrIA Analogues International Journal of Peptide Research and Therapeutics. 13: 307-312. DOI: 10.1007/S10989-007-9083-2 |
0.44 |
|
| 2007 |
Schnölzer M, Alewood P, Jones A, Alewood D, Kent SBH. In situ neutralization in boc-chemistry solid phase peptide synthesis: Rapid, high yield assembly of difficult sequences International Journal of Peptide Research and Therapeutics. 13: 31-44. DOI: 10.1007/S10989-006-9059-7 |
0.346 |
|
| 2006 |
Lovelace ES, Armishaw CJ, Colgrave ML, Wahlstrom ME, Alewood PF, Daly NL, Craik DJ. Cyclic MrIA: a stable and potent cyclic conotoxin with a novel topological fold that targets the norepinephrine transporter. Journal of Medicinal Chemistry. 49: 6561-8. PMID 17064074 DOI: 10.1021/Jm060299H |
0.454 |
|
| 2006 |
St Pierre L, Flight S, Masci PP, Hanchard KJ, Lewis RJ, Alewood PF, de Jersey J, Lavin MF. Cloning and characterisation of natriuretic peptides from the venom glands of Australian elapids. Biochimie. 88: 1923-31. PMID 16908092 DOI: 10.1016/J.Biochi.2006.06.014 |
0.44 |
|
| 2006 |
Imperial JS, Bansal PS, Alewood PF, Daly NL, Craik DJ, Sporning A, Terlau H, López-Vera E, Bandyopadhyay PK, Olivera BM. A novel conotoxin inhibitor of Kv1.6 channel and nAChR subtypes defines a new superfamily of conotoxins. Biochemistry. 45: 8331-40. PMID 16819832 DOI: 10.1021/Bi060263R |
0.449 |
|
| 2006 |
Dutertre S, Lumsden NG, Alewood PF, Lewis RJ. Isolation and characterisation of conomap-Vt, a D-amino acid containing excitatory peptide from the venom of a vermivorous cone snail. Febs Letters. 580: 3860-6. PMID 16797543 DOI: 10.1016/J.Febslet.2006.06.011 |
0.407 |
|
| 2006 |
Loughnan M, Nicke A, Jones A, Schroeder CI, Nevin ST, Adams DJ, Alewood PF, Lewis RJ. Identification of a novel class of nicotinic receptor antagonists: dimeric conotoxins VxXIIA, VxXIIB, and VxXIIC from Conus vexillum. The Journal of Biological Chemistry. 281: 24745-55. PMID 16790424 DOI: 10.1074/Jbc.M603703200 |
0.566 |
|
| 2006 |
Holland JW, Deeth HC, Alewood PF. Resolution and characterisation of multiple isoforms of bovine κ-casein by 2-DE following a reversible cysteine-tagging enrichment strategy Proteomics. 6: 3087-3095. PMID 16619295 DOI: 10.1002/Pmic.200500780 |
0.326 |
|
| 2006 |
Armishaw CJ, Daly NL, Nevin ST, Adams DJ, Craik DJ, Alewood PF. α-Selenoconotoxins, a new class of potent α7 neuronal nicotinic receptor antagonists Journal of Biological Chemistry. 281: 14136-14143. PMID 16500898 DOI: 10.1074/Jbc.M512419200 |
0.527 |
|
| 2006 |
Torres AM, Tsampazi M, Tsampazi C, Kennett EC, Belov K, Geraghty DP, Bansal PS, Alewood PF, Kuchel PW. Mammalian l-to-d-amino-acid-residue isomerase from platypus venom. Febs Letters. 580: 1587-91. PMID 16480722 DOI: 10.1016/J.Febslet.2006.01.089 |
0.346 |
|
| 2006 |
Brust A, Alewood D, Colless B, Palant E, Patterson B, Wilson DTR, Watson F, Schroeder CI, Alewood PF, Lewis RJ. conopeptide to drug: the development, structure and activity correlation of Xen2174 Journal of Peptide Science. 12: 516-516. DOI: 10.1002/Psc.797 |
0.41 |
|
| 2005 |
Bansal PS, Grieve PA, Marschke RJ, Daly NL, McGhie E, Craik DJ, Alewood PF. Chemical synthesis and structure elucidation of bovine kappa-casein (1-44). Biochemical and Biophysical Research Communications. 340: 1098-103. PMID 16403439 DOI: 10.1016/J.Bbrc.2005.12.115 |
0.361 |
|
| 2005 |
Torres AM, Tsampazi C, Geraghty DP, Bansal PS, Alewood PF, Kuchel PW. D-amino acid residue in a defensin-like peptide from platypus venom: effect on structure and chromatographic properties. The Biochemical Journal. 391: 215-20. PMID 16033333 DOI: 10.1042/Bj20050900 |
0.371 |
|
| 2005 |
Alewood D, Nielsen K, Alewood PF, Craik DJ, Andrews P, Nerrie M, White S, Domagala T, Walker F, Rothacker J, Burgess AW, Nice EC. The role of disulfide bonds in the structure and function of murine epidermal growth factor (mEGF). Growth Factors (Chur, Switzerland). 23: 97-110. PMID 16019431 DOI: 10.1080/08977190500096061 |
0.388 |
|
| 2005 |
Wen S, Wilson DT, Kuruppu S, Korsinczky ML, Hedrick J, Pang L, Szeto T, Hodgson WC, Alewood PF, Nicholson GM. Discovery of an MIT-like atracotoxin family: spider venom peptides that share sequence homology but not pharmacological properties with AVIT family proteins. Peptides. 26: 2412-26. PMID 15979762 DOI: 10.1016/J.Peptides.2005.05.012 |
0.417 |
|
| 2005 |
Armishaw CJ, Alewood PF. Conotoxins as research tools and drug leads. Current Protein & Peptide Science. 6: 221-40. PMID 15974949 DOI: 10.2174/1389203054065437 |
0.416 |
|
| 2005 |
Nilsson KP, Lovelace ES, Caesar CE, Tynngård N, Alewood PF, Johansson HM, Sharpe IA, Lewis RJ, Daly NL, Craik DJ. Solution structure of chi-conopeptide MrIA, a modulator of the human norepinephrine transporter. Biopolymers. 80: 815-23. PMID 15931669 DOI: 10.1002/Bip.20302 |
0.374 |
|
| 2005 |
Baudinette RV, Boontheung P, Musgrave IF, Wabnitz PA, Maselli VM, Skinner J, Alewood PF, Brinkworth CS, Bowie JH. An immunomodulator used to protect young in the pouch of the Tammar wallaby, Macropus eugenii. The Febs Journal. 272: 433-43. PMID 15654881 DOI: 10.1111/J.1742-4658.2004.04483.X |
0.407 |
|
| 2005 |
Fry BG, Wickramaratana JC, Lemme S, Beuve A, Garbers D, Hodgson WC, Alewood P. Novel natriuretic peptides from the venom of the inland taipan (Oxyuranus microlepidotus): isolation, chemical and biological characterisation. Biochemical and Biophysical Research Communications. 327: 1011-5. PMID 15652496 DOI: 10.1016/J.Bbrc.2004.11.171 |
0.386 |
|
| 2004 |
Wickramaratna JC, Fry BG, Loiacono RE, Aguilar MI, Alewood PF, Hodgson WC. Isolation and characterization at cholinergic nicotinic receptors of a neurotoxin from the venom of the Acanthophis sp. Seram death adder. Biochemical Pharmacology. 68: 383-94. PMID 15194010 DOI: 10.1016/J.Bcp.2004.03.033 |
0.34 |
|
| 2004 |
Loughnan ML, Alewood PF. Physico-chemical characterization and synthesis of neuronally active alpha-conotoxins. European Journal of Biochemistry. 271: 2294-304. PMID 15182345 DOI: 10.1111/J.1432-1033.2004.04146.X |
0.396 |
|
| 2004 |
Wijffels G, Dalrymple BP, Prosselkov P, Kongsuwan K, Epa VC, Lilley PE, Jergic S, Buchardt J, Brown SE, Alewood PF, Jennings PA, Dixon NE. Inhibition of protein interactions with the beta 2 sliding clamp of Escherichia coli DNA polymerase III by peptides from beta 2-binding proteins. Biochemistry. 43: 5661-71. PMID 15134440 DOI: 10.1021/Bi036229J |
0.319 |
|
| 2004 |
Holland JW, Deeth HC, Alewood PF. Proteomic analysis of κ-casein micro-heterogeneity Proteomics. 4: 743-752. PMID 14997496 DOI: 10.1002/Pmic.200300613 |
0.327 |
|
| 2004 |
Loughnan ML, Nicke A, Jones A, Adams DJ, Alewood PF, Lewis RJ. Chemical and functional identification and characterization of novel sulfated alpha-conotoxins from the cone snail Conus anemone. Journal of Medicinal Chemistry. 47: 1234-41. PMID 14971903 DOI: 10.1021/Jm031010O |
0.518 |
|
| 2004 |
Wilson D, Alewood P. Australian funnel-web spider venom analyzed with on-line RP-HPLC techniques. Methods in Molecular Biology (Clifton, N.J.). 251: 307-22. PMID 14704454 DOI: 10.1385/1-59259-742-4:307 |
0.311 |
|
| 2004 |
Alewood D, Birinyi-Strachan LC, Pallaghy PK, Norton RS, Nicholson GM, Alewood PF. Synthesis and characterization of delta-atracotoxin-Ar1a, the lethal neurotoxin from venom of the Sydney funnel-web spider (Atrax robustus). Biochemistry. 42: 12933-40. PMID 14596608 DOI: 10.1021/Bi030091N |
0.409 |
|
| 2003 |
Torres AM, Bansal PS, Sunde M, Clarke CE, Bursill JA, Smith DJ, Bauskin A, Breit SN, Campbell TJ, Alewood PF, Kuchel PW, Vandenberg JI. Structure of the HERG K+ channel S5P extracellular linker: role of an amphipathic alpha-helix in C-type inactivation. The Journal of Biological Chemistry. 278: 42136-48. PMID 12902341 DOI: 10.1074/Jbc.M212824200 |
0.387 |
|
| 2003 |
Sharpe IA, Palant E, Schroeder CI, Kaye DM, Adams DJ, Alewood PF, Lewis RJ. Inhibition of the norepinephrine transporter by the venom peptide chi-MrIA. Site of action, Na+ dependence, and structure-activity relationship. The Journal of Biological Chemistry. 278: 40317-23. PMID 12885787 DOI: 10.1074/Jbc.M213030200 |
0.495 |
|
| 2003 |
Sharpe IA, Thomas L, Loughnan M, Motin L, Palant E, Croker DE, Alewood D, Chen S, Graham RM, Alewood PF, Adams DJ, Lewis RJ. Allosteric alpha 1-adrenoreceptor antagonism by the conopeptide rho-TIA. The Journal of Biological Chemistry. 278: 34451-7. PMID 12824165 DOI: 10.1074/Jbc.M305410200 |
0.498 |
|
| 2003 |
Hogg RC, Hopping G, Alewood PF, Adams DJ, Bertrand D. Alpha-conotoxins PnIA and [A10L]PnIA stabilize different states of the alpha7-L247T nicotinic acetylcholine receptor. The Journal of Biological Chemistry. 278: 26908-14. PMID 12746432 DOI: 10.1074/Jbc.M212628200 |
0.449 |
|
| 2003 |
Torres AM, Bansal P, Alewood PF, Bursill JA, Kuchel PW, Vandenberg JI. Solution structure of CnErg1 (Ergtoxin), a HERG specific scorpion toxin. Febs Letters. 539: 138-42. PMID 12650941 DOI: 10.1016/S0014-5793(03)00216-3 |
0.351 |
|
| 2003 |
Blanchfield JT, Dutton JL, Hogg RC, Gallagher OP, Craik DJ, Jones A, Adams DJ, Lewis RJ, Alewood PF, Toth I. Synthesis, structure elucidation, in vitro biological activity, toxicity, and Caco-2 cell permeability of lipophilic analogues of alpha-conotoxin MII. Journal of Medicinal Chemistry. 46: 1266-72. PMID 12646037 DOI: 10.1021/Jm020426J |
0.579 |
|
| 2003 |
Nicke A, Loughnan ML, Millard EL, Alewood PF, Adams DJ, Daly NL, Craik DJ, Lewis RJ. Isolation, structure, and activity of GID, a novel alpha 4/7-conotoxin with an extended N-terminal sequence. The Journal of Biological Chemistry. 278: 3137-44. PMID 12419800 DOI: 10.1074/Jbc.M210280200 |
0.444 |
|
| 2003 |
Englebretsen DR, Garnham B, Alewood PF. A cassette ligation strategy with thioether replacement of three Gly-Gly peptide bonds: total chemical synthesis of the 101 residue protein early pregnancy factor [psi(CH(2)S)28-29,56-57,76-77]. The Journal of Organic Chemistry. 67: 5883-90. PMID 12182617 DOI: 10.1021/Jo016121E |
0.431 |
|
| 2003 |
Alewood P, Hopping G, Armishaw C. Marine Toxins as Sources of Drug Leads Australian Journal of Chemistry. 56: 769. DOI: 10.1071/Ch03043 |
0.377 |
|
| 2002 |
Dutton JL, Bansal PS, Hogg RC, Adams DJ, Alewood PF, Craik DJ. A new level of conotoxin diversity, a non-native disulfide bond connectivity in alpha-conotoxin AuIB reduces structural definition but increases biological activity. The Journal of Biological Chemistry. 277: 48849-57. PMID 12376538 DOI: 10.1074/Jbc.M208842200 |
0.556 |
|
| 2002 |
Torres AM, Alewood D, Alewood PF, Gallagher CH, Kuchel PW. Conformations of platypus venom C-type natriuretic peptide in aqueous solution and sodium dodecyl sulfate micelles. Toxicon : Official Journal of the International Society On Toxinology. 40: 711-9. PMID 12175607 DOI: 10.1016/S0041-0101(01)00266-5 |
0.359 |
|
| 2002 |
Torres AM, Menz I, Alewood PF, Bansal P, Lahnstein J, Gallagher CH, Kuchel PW. D-Amino acid residue in the C-type natriuretic peptide from the venom of the mammal, Ornithorhynchus anatinus, the Australian platypus. Febs Letters. 524: 172-6. PMID 12135762 DOI: 10.1016/S0014-5793(02)03050-8 |
0.373 |
|
| 2002 |
Nielsen KJ, Watson M, Adams DJ, Hammarström AK, Gage PW, Hill JM, Craik DJ, Thomas L, Adams D, Alewood PF, Lewis RJ. Solution structure of mu-conotoxin PIIIA, a preferential inhibitor of persistent tetrodotoxin-sensitive sodium channels. The Journal of Biological Chemistry. 277: 27247-55. PMID 12006587 DOI: 10.1074/Jbc.M201611200 |
0.501 |
|
| 2002 |
Rosengren KJ, Wilson D, Daly NL, Alewood PF, Craik DJ. Solution structures of the cis- and trans-Pro30 isomers of a novel 38-residue toxin from the venom of Hadronyche Infensa sp. that contains a cystine-knot motif within its four disulfide bonds. Biochemistry. 41: 3294-301. PMID 11876637 DOI: 10.1021/Bi011932Y |
0.379 |
|
| 2002 |
Boontheung P, Alewood PF, Brinkworth CS, Bowie JH, Wabnitz PA, Tyler MJ. Negative ion electrospray mass spectra of caerulein peptides: an aid to structural determination. Rapid Communications in Mass Spectrometry : Rcm. 16: 281-6. PMID 11816042 DOI: 10.1002/Rcm.577 |
0.349 |
|
| 2001 |
Bourne GT, Golding SW, McGeary RP, Meutermans WD, Jones A, Marshall GR, Alewood PF, Smythe ML. The development and application of a novel safety-catch linker for BOC-based assembly of libraries of cyclic peptides. The Journal of Organic Chemistry. 66: 7706-13. PMID 11701025 DOI: 10.1021/Jo010580Y |
0.431 |
|
| 2001 |
Sharpe IA, Gehrmann J, Loughnan ML, Thomas L, Adams DA, Atkins A, Palant E, Craik DJ, Adams DJ, Alewood PF, Lewis RJ. Two new classes of conopeptides inhibit the alpha1-adrenoceptor and noradrenaline transporter. Nature Neuroscience. 4: 902-7. PMID 11528421 DOI: 10.1038/Nn0901-902 |
0.523 |
|
| 2001 |
Wang XH, Connor M, Wilson D, Wilson HI, Nicholson GM, Smith R, Shaw D, Mackay JP, Alewood PF, Christie MJ, King GF. Discovery and structure of a potent and highly specific blocker of insect calcium channels. The Journal of Biological Chemistry. 276: 40306-12. PMID 11522785 DOI: 10.1074/Jbc.M105206200 |
0.326 |
|
| 2001 |
Wilce JA, Love SG, Richardson SJ, Alewood PF, Craik DJ. Synthesis of an analog of the thyroid hormone-binding protein transthyretin via regioselective chemical ligation. The Journal of Biological Chemistry. 276: 25997-6003. PMID 11352912 DOI: 10.1074/Jbc.M101228200 |
0.343 |
|
| 2001 |
Miranda LP, Tao T, Jones A, Chernushevich I, Standing KG, Geczy CL, Alewood PF. Total chemical synthesis and chemotactic activity of human S100A12 (EN-RAGE). Febs Letters. 488: 85-90. PMID 11163801 DOI: 10.1016/S0014-5793(00)02392-9 |
0.331 |
|
| 2001 |
Miranda LP, Alewood PF. Challenges for protein chemical synthesis in the 21st century: bridging genomics and proteomics. Biopolymers. 55: 217-26. PMID 11074416 DOI: 10.1002/1097-0282(2000)55:3<217::Aid-Bip40>3.0.Co;2-B |
0.353 |
|
| 2001 |
Blanchfield J, Dutton J, Hogg R, Craik D, Adams D, Lewis R, Alewood P, Toth I. The synthesis and structure of an n-terminal dodecanoic acid conjugate of α-conotoxin MII Letters in Peptide Science. 8: 235-239. DOI: 10.1023/A:1016577832311 |
0.555 |
|
| 2001 |
Blanchfield J, Dutton J, Hogg R, Craik D, Adams D, Lewis R, Alewood P, Toth I. Letters in Peptide Science. 8: 235-239. DOI: 10.1023/A:1016577832311 |
0.315 |
|
| 2000 |
Miranda LP, Meutermans WD, Smythe ML, Alewood PF. An activated O --> N acyl transfer auxiliary: efficient amide-backbone substitution of hindered "difficult" peptides. The Journal of Organic Chemistry. 65: 5460-8. PMID 10970282 DOI: 10.1021/Jo991340+ |
0.408 |
|
| 2000 |
Lewis RJ, Nielsen KJ, Craik DJ, Loughnan ML, Adams DA, Sharpe IA, Luchian T, Adams DJ, Bond T, Thomas L, Jones A, Matheson JL, Drinkwater R, Andrews PR, Alewood PF. Novel omega-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes. The Journal of Biological Chemistry. 275: 35335-44. PMID 10938268 DOI: 10.1074/Jbc.M002252200 |
0.462 |
|
| 2000 |
Hill JM, Alewood PF, Craik DJ. Conotoxin TVIIA, a novel peptide from the venom of Conus tulipa 2. Three-dimensional solution structure. European Journal of Biochemistry / Febs. 267: 4649-57. PMID 10903497 DOI: 10.1046/J.1432-1327.2000.01507.X |
0.402 |
|
| 2000 |
Hill JM, Atkins AR, Loughnan ML, Jones A, Adams DA, Martin RC, Lewis RJ, Craik DJ, Alewood PF. Conotoxin TVIIA, a novel peptide from the venom of Conus tulipa 1. Isolation, characterization and chemical synthesis. European Journal of Biochemistry / Febs. 267: 4642-8. PMID 10903496 DOI: 10.1046/J.1432-1327.2000.01508.X |
0.453 |
|
| 2000 |
Broxton N, Miranda L, Gehrmann J, Down J, Alewood P, Livett B. Leu(10) of alpha-conotoxin PnIB confers potency for neuronal nicotinic responses in bovine chromaffin cells. European Journal of Pharmacology. 390: 229-36. PMID 10708728 DOI: 10.1016/S0014-2999(00)00023-6 |
0.386 |
|
| 1999 |
Bourne GT, Meutermans WD, Alewood PF, McGeary RP, Scanlon M, Watson AA, Smythe ML. A Backbone Linker for BOC-Based Peptide Synthesis and On-Resin Cyclization: Synthesis of Stylostatin 1(,). The Journal of Organic Chemistry. 64: 3095-3101. PMID 11674407 DOI: 10.1021/Jo9818780 |
0.422 |
|
| 1999 |
Hogg RC, Miranda LP, Craik DJ, Lewis RJ, Alewood PF, Adams DJ. Single amino acid substitutions in alpha-conotoxin PnIA shift selectivity for subtypes of the mammalian neuronal nicotinic acetylcholine receptor. The Journal of Biological Chemistry. 274: 36559-64. PMID 10593955 DOI: 10.1074/Jbc.274.51.36559 |
0.473 |
|
| 1999 |
Daly NL, Love S, Alewood PF, Craik DJ. Chemical synthesis and folding pathways of large cyclic polypeptides: studies of the cystine knot polypeptide kalata B1. Biochemistry. 38: 10606-14. PMID 10441158 DOI: 10.1021/Bi990605B |
0.419 |
|
| 1999 |
Gehrmann J, Daly NL, Alewood PF, Craik DJ. Solution structure of alpha-conotoxin ImI by 1H nuclear magnetic resonance. Journal of Medicinal Chemistry. 42: 2364-72. PMID 10395477 DOI: 10.1021/Jm990114P |
0.389 |
|
| 1999 |
Martin JL, Begun J, Schindeler A, Wickramasinghe WA, Alewood D, Alewood PF, Bergman DA, Brinkworth RI, Abbenante G, March DR, Reid RC, Fairlie DP. Molecular recognition of macrocyclic peptidomimetic inhibitors by HIV-1 protease. Biochemistry. 38: 7978-88. PMID 10387041 DOI: 10.1021/Bi990174X |
0.396 |
|
| 1999 |
Nielsen KJ, Adams D, Thomas L, Bond T, Alewood PF, Craik DJ, Lewis RJ. Structure-activity relationships of omega-conotoxins MVIIA, MVIIC and 14 loop splice hybrids at N and P/Q-type calcium channels. Journal of Molecular Biology. 289: 1405-21. PMID 10373375 DOI: 10.1006/Jmbi.1999.2817 |
0.532 |
|
| 1999 |
Nielsen KJ, Adams DA, Alewood PF, Lewis RJ, Thomas L, Schroeder T, Craik DJ. Effects of chirality at Tyr13 on the structure-activity relationships of omega-conotoxins from Conus magus. Biochemistry. 38: 6741-51. PMID 10346894 DOI: 10.1021/Bi982980U |
0.366 |
|
| 1999 |
Broxton NM, Down JG, Gehrmann J, Alewood PF, Satchell DG, Livett BG. Alpha-conotoxin ImI inhibits the alpha-bungarotoxin-resistant nicotinic response in bovine adrenal chromaffin cells. Journal of Neurochemistry. 72: 1656-62. PMID 10098874 DOI: 10.1046/J.1471-4159.1999.721656.X |
0.322 |
|
| 1999 |
Barnham KJ, Torres AM, Alewood D, Alewood PF, Domagala T, Nice EC, Norton RS. Role of the 6-20 disulfide bridge in the structure and activity of epidermal growth factor. Protein Science : a Publication of the Protein Society. 7: 1738-49. PMID 10082370 DOI: 10.1002/Pro.5560070808 |
0.356 |
|
| 1999 |
Miranda LP, Alewood PF. Accelerated chemical synthesis of peptides and small proteins. Proceedings of the National Academy of Sciences of the United States of America. 96: 1181-6. PMID 9989998 DOI: 10.1073/Pnas.96.4.1181 |
0.442 |
|
| 1999 |
TORRES AM, WANG X, FLETCHER JI, ALEWOOD D, ALEWOOD PF, SMITH R, SIMPSON RJ, NICHOLSON GM, SUTHERLAND SK, GALLAGHER CH, KING GF, KUCHEL PW. Solution structure of a defensin-like peptide from platypus venom Biochemical Journal. 341: 785. DOI: 10.1042/0264-6021:3410785 |
0.433 |
|
| 1999 |
Adams DJ, Alewood PF, Craik DJ, Drinkwater RD, Lewis RJ. Conotoxins and their potential pharmaceutical applications Drug Development Research. 46: 219-234. DOI: 10.1002/(Sici)1098-2299(199903/04)46:3/4<219::Aid-Ddr7>3.0.Co;2-S |
0.536 |
|
| 1998 |
Hill JM, Oomen CJ, Miranda LP, Bingham JP, Alewood PF, Craik DJ. Three-dimensional solution structure of alpha-conotoxin MII by NMR spectroscopy: effects of solution environment on helicity. Biochemistry. 37: 15621-30. PMID 9843366 DOI: 10.1021/Bi981535W |
0.362 |
|
| 1998 |
Wu QX, King MA, Donovan GR, Alewood D, Alewood P, Sawyer WH, Baldo BA. Cytotoxicity of pilosulin 1, a peptide from the venom of the jumper ant Myrmecia pilosula. Biochimica Et Biophysica Acta. 1425: 74-80. PMID 9813247 DOI: 10.1016/S0304-4165(98)00052-X |
0.378 |
|
| 1998 |
Hu SH, Loughnan M, Miller R, Weeks CM, Blessing RH, Alewood PF, Lewis RJ, Martin JL. The 1.1 A resolution crystal structure of [Tyr15]EpI, a novel alpha-conotoxin from Conus episcopatus, solved by direct methods. Biochemistry. 37: 11425-33. PMID 9708977 DOI: 10.1021/Bi9806549 |
0.412 |
|
| 1998 |
Loughnan M, Bond T, Atkins A, Cuevas J, Adams DJ, Broxton NM, Livett BG, Down JG, Jones A, Alewood PF, Lewis RJ. alpha-conotoxin EpI, a novel sulfated peptide from Conus episcopatus that selectively targets neuronal nicotinic acetylcholine receptors. The Journal of Biological Chemistry. 273: 15667-74. PMID 9624161 DOI: 10.1074/Jbc.273.25.15667 |
0.557 |
|
| 1998 |
Gehrmann J, Alewood PF, Craik DJ. Structure determination of the three disulfide bond isomers of alpha-conotoxin GI: a model for the role of disulfide bonds in structural stability. Journal of Molecular Biology. 278: 401-15. PMID 9571060 DOI: 10.1006/Jmbi.1998.1701 |
0.427 |
|
| 1998 |
Pallaghy PK, Alewood D, Alewood PF, Norton RS. Solution structure of robustoxin, the lethal neurotoxin from the funnel-web spider Atrax robustus. Febs Letters. 419: 191-6. PMID 9428632 DOI: 10.1016/S0014-5793(97)01452-X |
0.343 |
|
| 1998 |
Miranda LP, Jones A, Meutermans WDF, Alewood PF. p-Cresol As a Reversible Acylium Ion Scavenger in Solid-Phase Peptide Synthesis Journal of the American Chemical Society. 120: 1410-1420. DOI: 10.1021/Ja973322K |
0.384 |
|
| 1997 |
Scanlon MJ, Naranjo D, Thomas L, Alewood PF, Lewis RJ, Craik DJ. Solution structure and proposed binding mechanism of a novel potassium channel toxin kappa-conotoxin PVIIA. Structure (London, England : 1993). 5: 1585-97. PMID 9438859 DOI: 10.1016/S0969-2126(97)00307-9 |
0.344 |
|
| 1997 |
Alewood P, Alewood D, Miranda L, Love S, Meutermans W, Wilson D. Rapid in situ neutralization protocols for Boc and Fmoc solid-phase chemistries. Methods in Enzymology. 289: 14-29. PMID 9353715 DOI: 10.1016/S0076-6879(97)89041-6 |
0.411 |
|
| 1997 |
Hu SH, Gehrmann J, Alewood PF, Craik DJ, Martin JL. Crystal structure at 1.1 A resolution of alpha-conotoxin PnIB: comparison with alpha-conotoxins PnIA and GI. Biochemistry. 36: 11323-30. PMID 9298951 DOI: 10.1021/Bi9713052 |
0.383 |
|
| 1997 |
Hill JM, Alewood PF, Craik DJ. Solution structure of the sodium channel antagonist conotoxin GS: a new molecular caliper for probing sodium channel geometry. Structure (London, England : 1993). 5: 571-83. PMID 9115446 DOI: 10.1016/S0969-2126(97)00212-8 |
0.341 |
|
| 1997 |
Skjaerbaek N, Nielsen KJ, Lewis RJ, Alewood P, Craik DJ. Determination of the solution structures of conantokin-G and conantokin-T by CD and NMR spectroscopy. The Journal of Biological Chemistry. 272: 2291-9. PMID 8999936 DOI: 10.1074/Jbc.272.4.2291 |
0.368 |
|
| 1997 |
Hu SH, Gehrmann J, Guddat LW, Alewood PF, Craik DJ, Martin JL. The 1.1 A crystal structure of the neuronal acetylcholine receptor antagonist, alpha-conotoxin PnIA from Conus pennaceus. Structure (London, England : 1993). 4: 417-23. PMID 8740364 DOI: 10.1016/S0969-2126(96)00047-0 |
0.403 |
|
| 1997 |
Meutermans WDF, Alewood PF, Bourne GT, Hawkins B, Smythe ML. Synthesis of α-aspartyl-containing cyclic peptides Letters in Peptide Science. 4: 79-84. DOI: 10.1023/A:1008878017315 |
0.41 |
|
| 1996 |
Nielsen KJ, Thomas L, Lewis RJ, Alewood PF, Craik DJ. A consensus structure for omega-conotoxins with different selectivities for voltage-sensitive calcium channel subtypes: comparison of MVIIA, SVIB and SNX-202. Journal of Molecular Biology. 263: 297-310. PMID 8913308 DOI: 10.1006/Jmbi.1996.0576 |
0.432 |
|
| 1996 |
Hill JM, Alewood PF, Craik DJ. Three-dimensional solution structure of mu-conotoxin GIIIB, a specific blocker of skeletal muscle sodium channels. Biochemistry. 35: 8824-35. PMID 8688418 DOI: 10.1021/Bi960073O |
0.373 |
|
| 1996 |
Raftery MJ, Harrison CA, Alewood P, Jones A, Geczy CL. Isolation of the murine S100 protein MRP14 (14 kDa migration-inhibitory-factor-related protein) from activated spleen cells: characterization of post-translational modifications and zinc binding. The Biochemical Journal. 316: 285-93. PMID 8645219 DOI: 10.1042/Bj3160285 |
0.351 |
|
| 1996 |
Jones A, Bingham JP, Gehrmann J, Bond T, Loughnan M, Atkins A, Lewis RJ, Alewood PF. Isolation and characterization of conopeptides by high-performance liquid chromatography combined with mass spectrometry and tandem mass spectrometry. Rapid Communications in Mass Spectrometry : Rcm. 10: 138-43. PMID 8563013 DOI: 10.1002/(Sici)1097-0231(19960115)10:1<138::Aid-Rcm442>3.0.Co;2-3 |
0.337 |
|
| 1996 |
Taylor C, Quinn RJ, Alewood P. Synthesis of cyclic peptides modelled on the microcystin and nodularin rings Bioorganic & Medicinal Chemistry Letters. 6: 2107-2112. DOI: 10.1016/0960-894X(96)00377-0 |
0.392 |
|
| 1996 |
Englebretsen DR, Alewood PF. Boc SPPS of two hydrophobic peptides using a “solubilising tail” strategy: dodecaalanine and chemotactic protein 1042–55 Tetrahedron Letters. 37: 8431-8434. DOI: 10.1016/0040-4039(96)01910-7 |
0.421 |
|
| 1996 |
Meutermans WD, Alewood PF. A simple and effective procedure for the synthesis of the ‘difficult’ phosphotyrosine-containing peptide stat 91 (695–708) Tetrahedron Letters. 37: 4765-4766. DOI: 10.1016/0040-4039(96)00929-X |
0.369 |
|
| 1995 |
Gooley AA, Pisano A, Packer NH, Ball M, Jones A, Alewood PF, Redmond JW, Williams KL. Characterization of a single glycosylated asparagine site on a glycopeptide using solid-phase Edman degradation. Glycoconjugate Journal. 11: 180-6. PMID 7841792 DOI: 10.1007/Bf00731216 |
0.323 |
|
| 1995 |
Englebretsen DR, Garnham BG, Bergman DA, Alewood PF. A novel thioether linker: Chemical synthesis of a HIV-1 protease analogue by thioether ligation Tetrahedron Letters. 36: 8871-8874. DOI: 10.1016/0040-4039(95)01843-7 |
0.409 |
|
| 1994 |
Monks SA, Gould AR, Lumley PE, Alewood PF, Kem WR, Goss NH, Norton RS. Limited proteolysis study of structure-function relationships in Sh I, a polypeptide neurotoxin from a sea anemone. Biochimica Et Biophysica Acta. 1207: 93-101. PMID 7913833 DOI: 10.1016/0167-4838(94)90056-6 |
0.409 |
|
| 1994 |
Donovan GR, Street MD, Baldo BA, Alewood D, Alewood P, Sutherland S. Identification of an IgE-binding determinant of the major allergen Myr p I from the venom of the Australian jumper ant Myrmecia pilosula. Biochimica Et Biophysica Acta. 1204: 48-52. PMID 7508264 DOI: 10.1016/0167-4838(94)90031-0 |
0.398 |
|
| 1994 |
Nicholls I, Alewood P. Design, Synthesis, and Opioid Receptor Binding of Some Novel Benzazepine Constrained Leucine Enkephalin Mimetics Bioorganic Chemistry. 22: 300-317. DOI: 10.1006/Bioo.1994.1024 |
0.407 |
|
| 1993 |
Nicholls IA, Morrison SF, Brinkworth RI, Alewood PF, Andrews PR. Central nervous system receptor binding profiles of some 2-amino-4-phenyl quinolines: a novel class of alpha 2-adrenoceptor selective ligands. Life Sciences. 53: PL343-7. PMID 8412517 DOI: 10.1016/0024-3205(93)90568-N |
0.348 |
|
| 1993 |
Alewood PF, Bailey AJ, Brinkworth RI, Fairlie D, Jones A. Characterisation of TNF-alpha-related peptides by high-performance liquid chromatography-mass spectrometry and high-performance liquid chromatography-tandem mass spectrometry. Journal of Chromatography. 646: 185-91. PMID 8408427 DOI: 10.1016/S0021-9673(99)87020-4 |
0.315 |
|
| 1993 |
Grieve PA, Jones A, Alewood PF. Analytical methods for differentiating minor sequence variations in related peptides. Journal of Chromatography. 646: 175-84. PMID 8408426 DOI: 10.1016/S0021-9673(99)87019-8 |
0.388 |
|
| 1993 |
Nash K, Feldmuller M, de Jersey J, Alewood P, Hamilton S. Continuous and discontinuous assays for phosphotyrosyl protein phosphatase activity using phosphotyrosyl peptide substrates. Analytical Biochemistry. 213: 303-9. PMID 8238906 DOI: 10.1006/Abio.1993.1425 |
0.388 |
|
| 1993 |
Ball JB, Hughes RA, Alewood PF, Andrews PR. β-turn topography Tetrahedron. 49: 3467-3478. DOI: 10.1016/S0040-4020(01)90207-8 |
0.307 |
|
| 1992 |
Schnölzer M, Alewood P, Jones A, Alewood D, Kent SB. In situ neutralization in Boc-chemistry solid phase peptide synthesis. Rapid, high yield assembly of difficult sequences. International Journal of Peptide and Protein Research. 40: 180-93. PMID 1478777 DOI: 10.1111/J.1399-3011.1992.Tb00291.X |
0.345 |
|
| 1992 |
Schnölzer M, Jones A, Alewood PF, Kent SB. Ion-spray tandem mass spectrometry in peptide synthesis: structural characterization of minor by-products in the synthesis of ACP(65-74). Analytical Biochemistry. 204: 335-43. PMID 1443533 DOI: 10.1016/0003-2697(92)90249-7 |
0.376 |
|
| 1992 |
Valerio RM, Alewood PF, Perich JW, Tong G, Johns RB. Synthesis of the simple peptide model ac-abu(po3H2)-NHMe Australian Journal of Chemistry. 45: 777-784. DOI: 10.1071/Ch9920777 |
0.365 |
|
| 1992 |
Alewood PF, Brinkworth RI, Dancer RJ, Garnham B, Jones A, Kent SB. Solid phase synthesis of hydroxyethylamine peptide bond isosteres: Synthesis of the potent HIV-1 protease inhibitor JG365 Tetrahedron Letters. 33: 977-980. DOI: 10.1016/S0040-4039(00)91592-2 |
0.35 |
|
| 1991 |
Perich J, Valerio R, Alewood P, Johns R. Synthesis of Casein Related Peptides and Phosphopeptides. XIV. Solid Phase Synthesis of Glu-Ser(P)-Leu Through the Use of Protected Boc-Ser(PO3R2)-OH Derivatives Australian Journal of Chemistry. 44: 771. DOI: 10.1071/Ch9910771 |
0.399 |
|
| 1991 |
Perich JW, Alewood PF, Johns RB. Synthesis of casein-related peptides and phosphopeptides. ix. a modified method for the synthesis of ser(p) peptides by using ppoc-ser(PO) Australian Journal of Chemistry. 44: 377-387. DOI: 10.1071/Ch9910377 |
0.335 |
|
| 1991 |
Perich JW, Alewood PF, Johns RB. Synthesis of Casein-Related Peptides and Phosphopeptides. VII. The Efficient Synthesis of Ser(P)-Containing Peptides by the Use of Boc-Ser(PO Australian Journal of Chemistry. 44: 233-252. DOI: 10.1071/Ch9910233 |
0.384 |
|
| 1990 |
Ball JB, Andrews PR, Alewood PF, Hughes RA. A one-variable topographical descriptor for the β-turns of peptides and proteins Febs Letters. 273: 15-18. PMID 2226846 DOI: 10.1016/0014-5793(90)81040-U |
0.386 |
|
| 1990 |
Ball JB, Alewood PF. Conformational constraints: nonpeptide beta-turn mimics Journal of Molecular Recognition : Jmr. 3: 55-64. PMID 2163268 DOI: 10.1002/Jmr.300030202 |
0.332 |
|
| 1989 |
Valerio RM, Perich JW, Kitas EA, Alewood PF, Johns RB. Synthesis of o-phosphotyrosine-containing peptides. II* solution-phase synthesis of asn-glu-PTyr-Thr-Ala through methyl phosphate protection Australian Journal of Chemistry. 42: 1519-1525. DOI: 10.1071/Ch9891519 |
0.349 |
|
| 1987 |
Perich JW, Alewood PF, Johns RB. Synthesis of casein-related peptides and phosphopeptides. I Solution-Phase Synthesis and 13C N.M.R. Spectroscopy of the Nα-Acetyl Octapeptide N-methylamide corresponding to region 14-21 of bovine β-Casein A2 Australian Journal of Chemistry. 40: 257-271. DOI: 10.1071/Ch9870257 |
0.376 |
|
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