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Kristin K. Isaacs, Ph.D. - Publications

Affiliations: 
2002 Vanderbilt University, Nashville, TN 
Area:
Biomedical Engineering
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61 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2025 Wambaugh JF, Bare JC, Carignan CC, Dionisio KL, Dodson RE, Jolliet O, Liu X, Meyer DE, Newton SR, Phillips KA, Price PS, Ring CL, Shin HM, Sobus JR, Tal T, ... ... Isaacs KK, et al. New Approach Methodologies for Exposure Science. Current Opinion in Toxicology. 15: 76-92. PMID 39748807 DOI: 10.1016/j.cotox.2019.07.001  0.484
2024 Stanfield Z, Setzer RW, Hull V, Sayre RR, Isaacs KK, Wambaugh JF. Characterizing Chemical Exposure Trends from NHANES Urinary Biomonitoring Data. Environmental Health Perspectives. 132: 17009. PMID 38285237 DOI: 10.1289/EHP12188  0.439
2023 Zaleski RT, Ahrens A, Arnot JA, Becker RA, Bonnell M, Collins S, DeLeo P, Egeghy P, Embry M, Gouin T, Isaacs K, Jensen E. Quantitative Structure Use Relationships: Highlights from a technical summit meeting. Regulatory Toxicology and Pharmacology : Rtp. 145: 105516. PMID 37838348 DOI: 10.1016/j.yrtph.2023.105516  0.41
2023 Buckley TJ, Egeghy PP, Isaacs K, Richard AM, Ring C, Sayre RR, Sobus JR, Thomas RS, Ulrich EM, Wambaugh JF, Williams AJ. Cutting-edge computational chemical exposure research at the U.S. Environmental Protection Agency. Environment International. 178: 108097. PMID 37478680 DOI: 10.1016/j.envint.2023.108097  0.474
2023 Isaacs KK, Wall JT, Paul Friedman K, Franzosa JA, Goeden H, Williams AJ, Dionisio KL, Lambert JC, Linnenbrink M, Singh A, Wambaugh JF, Bogdan AR, Greene C. Screening for drinking water contaminants of concern using an automated exposure-focused workflow. Journal of Exposure Science & Environmental Epidemiology. PMID 37193773 DOI: 10.1038/s41370-023-00552-y  0.352
2023 Minucci JM, Purucker ST, Isaacs KK, Wambaugh JF, Phillips KA. A Data-Driven Approach to Estimating Occupational Inhalation Exposure Using Workplace Compliance Data. Environmental Science & Technology. 57: 5947-5956. PMID 36995295 DOI: 10.1021/acs.est.2c08234  0.438
2023 Langstaff J, Glen G, Holder C, Graham S, Isaacs K. A sensitivity analysis of a human exposure model using the Sobol method. Stochastic Environmental Research and Risk Assessment : Research Journal. 36: 3945-3960. PMID 36733914 DOI: 10.1007/s00477-022-02238-7  0.434
2022 Isaacs KK, Egeghy P, Dionisio KL, Phillips KA, Zidek A, Ring C, Sobus JR, Ulrich EM, Wetmore BA, Williams AJ, Wambaugh JF. The chemical landscape of high-throughput new approach methodologies for exposure. Journal of Exposure Science & Environmental Epidemiology. PMID 36435938 DOI: 10.1038/s41370-022-00496-9  0.471
2022 Stanfield Z, Setzer RW, Hull V, Sayre RR, Isaacs KK, Wambaugh JF. Bayesian inference of chemical exposures from NHANES urine biomonitoring data. Journal of Exposure Science & Environmental Epidemiology. PMID 35978002 DOI: 10.1038/s41370-022-00459-0  0.435
2022 El-Masri H, Paul Friedman K, Isaacs K, Wetmore BA. Advances in computational methods along the exposure to toxicological response paradigm. Toxicology and Applied Pharmacology. 450: 116141. PMID 35777528 DOI: 10.1016/j.taap.2022.116141  0.4
2022 Isaacs KK, Wall JT, Williams AR, Hobbie KA, Sobus JR, Ulrich E, Lyons D, Dionisio KL, Williams AJ, Grulke C, Foster CA, McCoy J, Bevington C. A harmonized chemical monitoring database for support of exposure assessments. Scientific Data. 9: 314. PMID 35710792 DOI: 10.1038/s41597-022-01365-8  0.391
2021 East A, Dawson D, Glen G, Isaacs K, Dionisio K, Price PS, Hubal EAC, Vallero DA. The Residential Population Generator (RPGen): Parameterization of Residential, Demographic, and Physiological Data to Model Intraindividual Exposure, Dose, and Risk. Toxics. 9. PMID 34822694 DOI: 10.3390/toxics9110303  0.384
2021 Lowe CN, Phillips KA, Favela KA, Yau AY, Wambaugh JF, Sobus JR, Williams AJ, Pfirrman AJ, Isaacs KK. Chemical Characterization of Recycled Consumer Products Using Suspect Screening Analysis. Environmental Science & Technology. PMID 34347456 DOI: 10.1021/acs.est.1c01907  0.349
2021 Stanfield Z, Addington CK, Dionisio KL, Lyons D, Tornero-Velez R, Phillips KA, Buckley TJ, Isaacs KK. Mining of Consumer Product Ingredient and Purchasing Data to Identify Potential Chemical Coexposures. Environmental Health Perspectives. 129: 67006. PMID 34160298 DOI: 10.1289/EHP8610  0.315
2020 Tornero-Velez R, Isaacs K, Dionisio K, Prince S, Laws H, Nye M, Price PS, Buckley TJ. Data Mining Approaches for Assessing Chemical Coexposures Using Consumer Product Purchase Data. Risk Analysis : An Official Publication of the Society For Risk Analysis. PMID 33331033 DOI: 10.1111/risa.13650  0.303
2020 Qin M, Murphy BN, Isaacs KK, McDonald BC, Lu Q, McKeen SA, Koval L, Robinson AL, Efstathiou C, Allen C, Pye HOT. Criteria pollutant impacts of volatile chemical products informed by near-field modeling. Nature Sustainability. 1-57. PMID 33134558 DOI: 10.1038/s41893-020-00614-1  0.339
2020 Panagopoulos Abrahamsson D, Sobus JR, Ulrich EM, Isaacs K, Moschet C, Young TM, Bennett DH, Tulve NS. A quest to identify suitable organic tracers for estimating children's dust ingestion rates. Journal of Exposure Science & Environmental Epidemiology. PMID 32661335 DOI: 10.1038/S41370-020-0244-0  0.446
2020 Brandon N, Dionisio KL, Isaacs K, Tornero-Velez R, Kapraun D, Setzer RW, Price PS. Simulating exposure-related behaviors using agent-based models embedded with needs-based artificial intelligence. Journal of Exposure Science and Environmental Epidemiology. 30: 184-193. PMID 30242268 DOI: 10.1038/S41370-018-0052-Y  0.458
2019 Addington CK, Phillips K, Isaacs KK. Estimation of the Emission Characteristics of SVOCs from Household Articles Using Group Contribution Methods. Environmental Science & Technology. PMID 31822065 DOI: 10.1021/Acs.Est.9B06118  0.425
2019 Isaacs KK, Dionisio K, Phillips K, Bevington C, Egeghy P, Price PS. Establishing a system of consumer product use categories to support rapid modeling of human exposure. Journal of Exposure Science & Environmental Epidemiology. PMID 31712628 DOI: 10.1038/S41370-019-0187-5  0.472
2019 Turley AE, Isaacs KK, Wetmore BA, Karmaus AL, Embry MR, Krishan M. Incorporating new approach methodologies in toxicity testing and exposure assessment for tiered risk assessment using the RISK21 approach: Case studies on food contact chemicals. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. 110819. PMID 31545997 DOI: 10.1016/J.Fct.2019.110819  0.426
2019 Thomas RS, Bahadori T, Buckley TJ, Cowden J, Deisenroth C, Dionisio KL, Frithsen JB, Grulke CM, Gwinn MR, Harrill JA, Higuchi M, Houck KA, Hughes MF, Hunter ES, Isaacs KK, et al. The next generation blueprint of computational toxicology at the U.S. Environmental Protection Agency. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 30835285 DOI: 10.1093/Toxsci/Kfz058  0.408
2019 Wambaugh JF, Bare JC, Carignan CC, Dionisio KL, Dodson RE, Jolliet O, Liu X, Meyer DE, Newton SR, Phillips KA, Price PS, Ring CL, Shin H, Sobus JR, Tal T, ... ... Isaacs KK, et al. New approach methodologies for exposure science Current Opinion in Toxicology. 15: 76-92. DOI: 10.1016/J.Cotox.2019.07.001  0.547
2018 Ring CL, Arnot J, Bennett DH, Egeghy P, Fantke P, Huang L, Isaacs KK, Jolliet O, Phillips K, Price PS, Shin HM, Westgate JN, Setzer RW, Wambaugh JF. Consensus Modeling of Median Chemical Intake for the U.S. Population Based on Predictions of Exposure Pathways. Environmental Science & Technology. PMID 30516957 DOI: 10.1021/Acs.Est.8B04056  0.521
2018 Dionisio KL, Phillips K, Price PS, Grulke CM, Williams A, Biryol D, Hong T, Isaacs KK. The Chemical and Products Database, a resource for exposure-relevant data on chemicals in consumer products. Scientific Data. 5: 180125. PMID 29989593 DOI: 10.1038/Sdata.2018.125  0.446
2018 Nicolas CI, Mansouri K, Phillips KA, Grulke CM, Richard AM, Williams AJ, Rabinowitz J, Isaacs KK, Yau A, Wambaugh JF. Rapid experimental measurements of physicochemical properties to inform models and testing. The Science of the Total Environment. 636: 901-909. PMID 29729507 DOI: 10.1016/J.Scitotenv.2018.04.266  0.428
2018 Phillips K, Yau AY, Favela KA, Isaacs KK, McEachran A, Grulke CM, Richard AM, Williams A, Sobus JR, Thomas RS, Wambaugh JF. Suspect Screening Analysis of Chemicals in Consumer Products. Environmental Science & Technology. PMID 29405058 DOI: 10.1021/Acs.Est.7B04781  0.475
2018 Phillips K, Isaacs K, Dionisio K, Wambaugh J, Williams A. The U.S. EPA Activities and Information Systems Used for Chemical Exposure Screening, Modelling and Prioritisation and Risk-Based Decision Making: Needs, Challenges and Opportunities for Data Sharing and Interoperability of Tools on Global Scale Including IPCHEM Isee Conference Abstracts. 2018. DOI: 10.1289/isesisee.2018.s03.03.26  0.315
2018 Isaacs K, Phillips K, Wambaugh J, Price P, Dionisio K. Rapid Parameterization of Pathway-Specific Exposure Models Isee Conference Abstracts. 2018. DOI: 10.1289/isesisee.2018.s02.02.07  0.362
2018 Isaacs K, Setzer RW, Dodson RE, Rudel R, Biryol D, Wambaugh J. Evaluation of High-Throughput Chemical Exposure Models: Case Study of Matched Environmental and Biological Measurements Isee Conference Abstracts. 2018. DOI: 10.1289/isesisee.2018.s01.01.28  0.393
2018 Huang L, Fantke P, Isaacs K, Jolliet O. Stochastic Modeling of Exposure to Chemicals in Consumer Products Isee Conference Abstracts. 2018. DOI: 10.1289/isesisee.2018.p02.3530  0.406
2018 Tan C, Leonard J, Wambaugh J, Isaacs K, Villeneuve D, LaLone C, Edwards S, Williams A, Grulke C. Free access platforms for integrating environmental chemical exposure and hazard information Toxicology Letters. 295: S29. DOI: 10.1016/J.Toxlet.2018.06.1129  0.448
2017 Phillips KA, Wambaugh JF, Grulke CM, Dionisio KL, Isaacs KK. High-throughput screening of chemicals as functional substitutes using structure-based classification models. Green Chemistry : An International Journal and Green Chemistry Resource : Gc. 19: 1063-1074. PMID 30505234 DOI: 10.1039/C6Gc02744J  0.402
2017 Sobus JR, Wambaugh JF, Isaacs KK, Williams AJ, McEachran AD, Richard AM, Grulke CM, Ulrich EM, Rager JE, Strynar MJ, Newton SR. Integrating tools for non-targeted analysis research and chemical safety evaluations at the US EPA. Journal of Exposure Science & Environmental Epidemiology. PMID 29288256 DOI: 10.1038/S41370-017-0012-Y  0.47
2017 Isaacs KK, Phillips KA, Biryol D, Dionisio KL, Price PS. Consumer product chemical weight fractions from ingredient lists. Journal of Exposure Science & Environmental Epidemiology. PMID 29115287 DOI: 10.1038/Jes.2017.29  0.486
2017 Biryol D, Nicolas CI, Wambaugh J, Phillips K, Isaacs K. High-throughput dietary exposure predictions for chemical migrants from food contact substances for use in chemical prioritization. Environment International. 108: 185-194. PMID 28865378 DOI: 10.1016/J.Envint.2017.08.004  0.486
2017 Moreau M, Leonard J, Phillips KA, Campbell J, Pendse SN, Nicolas C, Phillips M, Yoon M, Tan YM, Smith S, Pudukodu H, Isaacs K, Clewell H. Using exposure prediction tools to link exposure and dosimetry for risk-based decisions: A case study with phthalates. Chemosphere. 184: 1194-1201. PMID 28672700 DOI: 10.1016/J.Chemosphere.2017.06.098  0.49
2017 Craig Barber M, Isaacs KK, Tebes-Stevens C. Developing and applying metamodels of high resolution process-based simulations for high throughput exposure assessment of organic chemicals in riverine ecosystems. The Science of the Total Environment. 605: 471-481. PMID 28672236 DOI: 10.1016/J.Scitotenv.2017.06.198  0.436
2017 Dionisio KL, Nolte CG, Spero TL, Graham S, Caraway N, Foley KM, Isaacs KK. Characterizing the impact of projected changes in climate and air quality on human exposures to ozone. Journal of Exposure Science & Environmental Epidemiology. PMID 28120830 DOI: 10.1038/Jes.2016.81  0.392
2016 Isaacs KK, Goldsmith MR, Egeghy P, Phillips K, Brooks R, Hong T, Wambaugh JF. Characterization and prediction of chemical functions and weight fractions in consumer products. Toxicology Reports. 3: 723-732. PMID 28959598 DOI: 10.1016/J.Toxrep.2016.08.011  0.479
2016 Csiszar SA, Meyer DE, Dionisio KL, Egeghy P, Isaacs KK, Price P, Scanlon KA, Tan YC, Thomas K, Vallero D, Bare JC. A conceptual framework to extend life cycle assessment using near-field human exposure modeling and high-throughput tools for chemicals. Environmental Science & Technology. PMID 27668689 DOI: 10.1021/Acs.Est.6B02277  0.432
2016 El-Masri H, Kleinstreuer N, Hines RN, Adams L, Tal T, Isaacs K, Wetmore BA, Tan YM. Integration of Life-Stage Physiologically-Based Pharmacokinetic (PBPK) Models with Adverse Outcome Pathways (AOPs) and Environmental Exposure Models to Screen for Environmental Hazards. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 27208077 DOI: 10.1093/Toxsci/Kfw082  0.505
2016 Leonard JA, Sobel Leonard A, Chang D, Edwards S, Lu J, Scholle S, Key P, Winter M, Isaacs KK, Tan YC. Evaluating the Impact of Uncertainties in Clearance and Exposure When Prioritizing Chemicals Screened in High-Throughput Assays. Environmental Science & Technology. PMID 27124219 DOI: 10.1021/Acs.Est.6B00374  0.456
2016 Leonard JA, Tan YM, Gilbert M, Isaacs K, El-Masri H. Estimating Margin of Exposure to Thyroid Peroxidase Inhibitors Using High-throughput In Vitro Data, High-throughput Exposure Modeling, and Physiologically-Based Pharmacokinetic/Pharmacodynamic Modeling. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 26865668 DOI: 10.1093/Toxsci/Kfw022  0.499
2016 Rager JE, Strynar MJ, Liang S, McMahen RL, Richard AM, Grulke CM, Wambaugh JF, Isaacs KK, Judson R, Williams AJ, Sobus JR. Linking high resolution mass spectrometry data with exposure and toxicity forecasts to advance high-throughput environmental monitoring. Environment International. 88: 269-280. PMID 26812473 DOI: 10.1016/J.Envint.2015.12.008  0.454
2015 Egeghy PP, Sheldon LS, Isaacs KK, Özkaynak H, Goldsmith MR, Wambaugh JF, Judson RS, Buckley TJ. Computational Exposure Science: An Emerging Discipline to Support 21st-Century Risk Assessment. Environmental Health Perspectives. PMID 26545029 DOI: 10.1289/Ehp.1509748  0.387
2014 Isaacs KK, Glen WG, Egeghy P, Goldsmith MR, Smith L, Vallero D, Brooks R, Grulke CM, Özkaynak H. SHEDS-HT: an integrated probabilistic exposure model for prioritizing exposures to chemicals with near-field and dietary sources. Environmental Science & Technology. 48: 12750-9. PMID 25222184 DOI: 10.1021/Es502513W  0.535
2014 Phillips MB, Sobus JR, George BJ, Isaacs K, Conolly R, Tan YM. A new method for generating distributions of biomonitoring equivalents to support exposure assessment and prioritization. Regulatory Toxicology and Pharmacology : Rtp. 69: 434-42. PMID 24845241 DOI: 10.1016/J.Yrtph.2014.05.008  0.463
2014 Breen MS, Long TC, Schultz BD, Crooks J, Breen M, Langstaff JE, Isaacs KK, Tan YM, Williams RW, Cao Y, Geller AM, Devlin RB, Batterman SA, Buckley TJ. GPS-based microenvironment tracker (MicroTrac) model to estimate time-location of individuals for air pollution exposure assessments: model evaluation in central North Carolina. Journal of Exposure Science & Environmental Epidemiology. 24: 412-20. PMID 24619294 DOI: 10.1038/Jes.2014.13  0.45
2014 Goldsmith MR, Grulke CM, Brooks RD, Transue TR, Tan YM, Frame A, Egeghy PP, Edwards R, Chang DT, Tornero-Velez R, Isaacs K, Wang A, Johnson J, Holm K, Reich M, et al. Development of a consumer product ingredient database for chemical exposure screening and prioritization. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. 65: 269-79. PMID 24374094 DOI: 10.1016/J.Fct.2013.12.029  0.501
2014 Breen MS, Schultz BD, Sohn MD, Long T, Langstaff J, Williams R, Isaacs K, Meng QY, Stallings C, Smith L. A review of air exchange rate models for air pollution exposure assessments. Journal of Exposure Science & Environmental Epidemiology. 24: 555-63. PMID 23715084 DOI: 10.1038/Jes.2013.30  0.445
2013 Isaacs K, Burke J, Smith L, Williams R. Identifying housing and meteorological conditions influencing residential air exchange rates in the DEARS and RIOPA studies: development of distributions for human exposure modeling. Journal of Exposure Science & Environmental Epidemiology. 23: 248-58. PMID 23443234 DOI: 10.1038/Jes.2012.131  0.413
2013 Isaacs K, McCurdy T, Glen G, Nysewander M, Errickson A, Forbes S, Graham S, McCurdy L, Smith L, Tulve N, Vallero D. Statistical properties of longitudinal time-activity data for use in human exposure modeling Journal of Exposure Science and Environmental Epidemiology. 23: 328-336. PMID 23047319 DOI: 10.1038/Jes.2012.94  0.438
2013 Wambaugh J, Wang A, Strope C, Chang D, Goldsmith R, Egeghy P, Isaacs K, Liddell A, Judson R, Setzer RW, Cohen Hubal E, Vallero D. Rapidly Parameterized Consumer Use Modeling for High-Throughput Exposure Predictions Isee Conference Abstracts. 2013: 5319. DOI: 10.1289/isee.2013.p-1-13-15  0.374
2013 Ozkaynak H, Isaacs K, Xue J, Goldsmith R, Egeghy P, Vallero D, Wambaugh J. High Throughput Exposure Prioritization of Chemicals Using a Screening-Level Probabilistic SHEDS-Lite Exposure Model Isee Conference Abstracts. 2013: 4222. DOI: 10.1289/isee.2013.p-1-08-13  0.399
2012 Glen G, Isaacs K. Estimating Sobol sensitivity indices using correlations Environmental Modelling and Software. 37: 157-166. DOI: 10.1016/J.Envsoft.2012.03.014  0.318
2011 Smyth HDC, Martonen TB, Isaacs KK, Hickey AJ. Estimation of particle deposition in the airways from different inhaler formulations using an in silico model Kona Powder and Particle Journal. 29: 107-117. DOI: 10.14356/Kona.2011013  0.357
2008 Isaacs K, Glen G, Mccurdy T, Smith L. Modeling energy expenditure and oxygen consumption in human exposure models: accounting for fatigue and EPOC. Journal of Exposure Science and Environmental Epidemiology. 18: 289-298. PMID 17805234 DOI: 10.1038/Sj.Jes.7500594  0.355
2008 Glen G, Smith L, Isaacs K, Mccurdy T, Langstaff J. A new method of longitudinal diary assembly for human exposure modeling. Journal of Exposure Science & Environmental Epidemiology. 18: 299-311. PMID 17805233 DOI: 10.1038/Sj.Jes.7500595  0.421
2005 Martonen T, Isaacs K, Hwang D. Three-dimensional simulations of airways within human lungs. Cell Biochemistry and Biophysics. 42: 223-249. PMID 15976457 DOI: 10.1385/Cbb:42:3:223  0.321
2004 Isaacs KK, Evans MV, Harris TR. Visualization-based analysis for a mixed-inhibition binary PBPK model: determination of inhibition mechanism. Journal of Pharmacokinetics and Pharmacodynamics. 31: 215-42. PMID 15518245 DOI: 10.1023/B:Jopa.0000039565.11358.94  0.343
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