Year |
Citation |
Score |
2020 |
Nie C, Li Q, Qiao Y, Hu J, Gao M, Wang Y, Qiao Z, Wang Q, Yan L, Qian H. Study on chemical modification and analgesic activity of N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl) piperazine-1-carboxamide. European Journal of Medicinal Chemistry. 194: 112236. PMID 32217416 DOI: 10.1016/J.Ejmech.2020.112236 |
0.357 |
|
2019 |
Wang Y, Su L, Wang Q, Zhang L, Luan Y. Novel histone deacetylase inhibitors bearing a 4-piperidin-4-yl-triazole scaffold as antitumor agents. Drug Development Research. PMID 31580523 DOI: 10.1002/Ddr.21603 |
0.351 |
|
2019 |
Li J, Nie C, Qiao Y, Hu J, Li Q, Wang Q, Pu X, Yan L, Qian H. Design, synthesis and biological evaluation of novel 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole triazole derivatives as potent TRPV1 antagonists. European Journal of Medicinal Chemistry. 178: 433-445. PMID 31202991 DOI: 10.1016/J.Ejmech.2019.06.007 |
0.328 |
|
2018 |
Wu G, Qi X, Mo X, Yu G, Wang Q, Zhu T, Gu Q, Liu M, Li J, Li D. Structure-based discovery of cytotoxic dimeric tetrahydroxanthones as potential topoisomerase I inhibitors from a marine-derived fungus. European Journal of Medicinal Chemistry. 148: 268-278. PMID 29466776 DOI: 10.1016/J.Ejmech.2018.02.041 |
0.349 |
|
2017 |
Mou J, Luan Y, Chen D, Wang Q. Novel L-arginine derivatives as aminopeptidase N inhibitors: design, chemistry, and pharmacological evaluation Medicinal Chemistry Research. 26: 3015-3025. DOI: 10.1007/S00044-017-1999-2 |
0.387 |
|
2015 |
Zhang L, Han Y, Jiang Q, Wang C, Chen X, Li X, Xu F, Jiang Y, Wang Q, Xu W. Trend of histone deacetylase inhibitors in cancer therapy: isoform selectivity or multitargeted strategy. Medicinal Research Reviews. 35: 63-84. PMID 24782318 DOI: 10.1002/Med.21320 |
0.307 |
|
2015 |
Wang Q, Shi Q, Huang L. Novel Aminopeptidase N Inhibitors with Improved Antitumor Activities Letters in Drug Design & Discovery. 13: 98-106. DOI: 10.2174/1570180812666150611190608 |
0.35 |
|
2013 |
Shi L, Wang Q, Wang H, Zhou H, Li Y, Li X. Sulphonamide 1,4-dithia-7-azaspiro[4,4]nonane derivatives as gelatinase A inhibitors. Bioorganic & Medicinal Chemistry. 21: 7752-62. PMID 24247003 DOI: 10.1016/J.Bmc.2013.10.016 |
0.338 |
|
2012 |
Li Q, Fang H, Wang X, Hu G, Wang Q, Xu W. Novel potent 2,5-pyrrolidinedione peptidomimetics as aminopeptidase N inhibitors. Design, synthesis and activity evaluation. Bioorganic & Medicinal Chemistry Letters. 22: 850-3. PMID 22206607 DOI: 10.1016/J.Bmcl.2011.12.048 |
0.418 |
|
2011 |
Luan Y, Wang Q, Liu N, Mou J, Jiao X, Fang H, Li M, Xu W. Synthesis and activity evaluation of a new bestatin derivative LYP2 as an aminopeptidase N inhibitor Anti-Cancer Drugs. 22: 99-103. PMID 21048494 DOI: 10.1097/Cad.0B013E32833Ab78A |
0.362 |
|
2010 |
Wang Q, Xu F, Mou J, Zhang J, Shang L, Luan Y, Yuan Y, Liu Y, Li M, Fang H, Wang B, Xu W. Design, synthesis and preliminary activity evaluation of novel L-lysine derivatives as aminopeptidase N/CD13 inhibitors. Protein and Peptide Letters. 17: 847-53. PMID 20156182 DOI: 10.2174/092986610791306661 |
0.574 |
|
2010 |
Mou J, Fang H, Liu Y, Shang L, Wang Q, Zhang L, Xu W. Design, synthesis and primary activity assay of bi- or tri-peptide analogues with the scaffold l-arginine as amino-peptidase N/CD13 inhibitors. Bioorganic & Medicinal Chemistry. 18: 887-95. PMID 19969464 DOI: 10.1016/J.Bmc.2009.11.036 |
0.404 |
|
2009 |
Liu Y, Shang L, Fang H, Zhu H, Mu J, Wang Q, Wang X, Yuan Y, Xu W. Design, synthesis, and preliminary studies of the activity of novel derivatives of N-cinnamoyl-L-aspartic acid as inhibitors of aminopeptidase N/CD13. Bioorganic & Medicinal Chemistry. 17: 7398-404. PMID 19782572 DOI: 10.1016/J.Bmc.2009.07.014 |
0.405 |
|
2009 |
Mou J, Fang H, Jing F, Wang Q, Liu Y, Zhu H, Shang L, Wang X, Xu W. Design, synthesis and primary activity evaluation of L-arginine derivatives as amino-peptidase N/CD13 inhibitors. Bioorganic & Medicinal Chemistry. 17: 4666-73. PMID 19454370 DOI: 10.1016/J.Bmc.2009.04.056 |
0.425 |
|
2009 |
Yang K, Wang Q, Su L, Fang H, Wang X, Gong J, Wang B, Xu W. Design and synthesis of novel chloramphenicol amine derivatives as potent aminopeptidase N (APN/CD13) inhibitors. Bioorganic & Medicinal Chemistry. 17: 3810-7. PMID 19423354 DOI: 10.1016/J.Bmc.2009.04.038 |
0.591 |
|
2009 |
Shang L, Fang H, Zhu H, Wang X, Wang Q, Mu J, Wang B, Kishioka S, Xu W. Design, synthesis and SAR studies of tripeptide analogs with the scaffold 3-phenylpropane-1,2-diamine as aminopeptidase N/CD13 inhibitors. Bioorganic & Medicinal Chemistry. 17: 2775-84. PMID 19299146 DOI: 10.1016/J.Bmc.2009.02.034 |
0.596 |
|
2009 |
Zhu H, Fang H, Cheng X, Wang Q, Zhang L, Feng J, Xu W. 3D-QSAR study of pyrrolidine derivatives as matrix metalloproteinase-2 inhibitors Medicinal Chemistry Research. 18: 683-701. DOI: 10.1007/S00044-008-9160-X |
0.326 |
|
2008 |
Shang L, Wang Q, Fang H, Mu J, Wang X, Yuan Y, Wang B, Xu W. Novel 3-phenylpropane-1,2-diamine derivates as inhibitors of aminopeptidase N (APN). Bioorganic & Medicinal Chemistry. 16: 9984-90. PMID 18996018 DOI: 10.1016/J.Bmc.2008.10.025 |
0.575 |
|
2008 |
Cheng XC, Wang Q, Fang H, Tang W, Xu WF. Synthesis of new sulfonyl pyrrolidine derivatives as matrix metalloproteinase inhibitors. Bioorganic & Medicinal Chemistry. 16: 7932-8. PMID 18718763 DOI: 10.1016/J.Bmc.2008.07.073 |
0.362 |
|
2008 |
Wang Q, Chen M, Zhu H, Zhang J, Fang H, Wang B, Xu W. Design, synthesis, and QSAR studies of novel lysine derives as amino-peptidase N/CD13 inhibitors. Bioorganic & Medicinal Chemistry. 16: 5473-81. PMID 18467109 DOI: 10.1016/J.Bmc.2008.04.012 |
0.591 |
|
2008 |
Cheng XC, Wang Q, Fang H, Tang W, Xu WF. Design, synthesis and evaluation of novel sulfonyl pyrrolidine derivatives as matrix metalloproteinase inhibitors. Bioorganic & Medicinal Chemistry. 16: 5398-404. PMID 18440232 DOI: 10.1016/J.Bmc.2008.04.027 |
0.375 |
|
2008 |
Zhang J, Wang Q, Fang H, Xu W, Liu A, Du G. Design, synthesis, inhibitory activity, and SAR studies of hydrophobic p-aminosalicylic acid derivatives as neuraminidase inhibitors. Bioorganic & Medicinal Chemistry. 16: 3839-47. PMID 18304821 DOI: 10.1016/J.Bmc.2008.01.036 |
0.361 |
|
2008 |
Cheng XC, Wang Q, Fang H, Xu WF. Role of sulfonamide group in matrix metalloproteinase inhibitors. Current Medicinal Chemistry. 15: 368-73. PMID 18288991 DOI: 10.2174/092986708783497300 |
0.305 |
|
2008 |
Xu W, Cheng X, Wang Q, Fang H. Advances in Matrix Metalloproteinase Inhibitors Based on Pyrrolidine Scaffold Current Medicinal Chemistry. 15: 374-385. DOI: 10.2174/092986708783497373 |
0.332 |
|
2008 |
Jiao J, Wang Q, Zhu HW, Fang H, Xu WF. Synthesis and biological evaluation of a new series of histone deacetylases inhibitors Chinese Chemical Letters. 19: 673-675. DOI: 10.1016/J.Cclet.2008.04.010 |
0.379 |
|
2007 |
Cheng XC, Wang Q, Fang H, Tang W, Xu WF. Design, synthesis and preliminary evaluation of novel pyrrolidine derivatives as matrix metalloproteinase inhibitors. European Journal of Medicinal Chemistry. 43: 2130-9. PMID 18362041 DOI: 10.1016/J.Ejmech.2007.12.020 |
0.365 |
|
2007 |
Liu FZ, Fang H, Zhu HW, Wang Q, Yang Y, Xu WF. Design, synthesis, and preliminary evaluation of 4-(6-(3-nitroguanidino)hexanamido)pyrrolidine derivatives as potential iNOS inhibitors. Bioorganic & Medicinal Chemistry. 16: 578-85. PMID 17937988 DOI: 10.1016/J.Bmc.2007.04.030 |
0.4 |
|
2007 |
Zhang J, Wang Q, Fang H, Xu W, Liu A, Du G. Design, synthesis, inhibitory activity, and SAR studies of pyrrolidine derivatives as neuraminidase inhibitors. Bioorganic & Medicinal Chemistry. 15: 2749-58. PMID 17287121 DOI: 10.1016/J.Bmc.2007.01.020 |
0.378 |
|
2006 |
Zhang L, Zhang J, Fang H, Wang Q, Xu W. Design, synthesis and preliminary evaluation of new cinnamoyl pyrrolidine derivatives as potent gelatinase inhibitors. Bioorganic & Medicinal Chemistry. 14: 8286-94. PMID 17008101 DOI: 10.1016/J.Bmc.2006.09.015 |
0.4 |
|
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