| Year |
Citation |
Score |
| 2021 |
Wronski S, Beinke S, Obernolte H, Belyaev NN, Saunders KA, Lennon MG, Schaudien D, Braubach P, Jonigk D, Warnecke G, Zardo P, Fieguth HG, Wilkens L, Braun A, Hessel EM, et al. Rhinovirus-induced Human Lung Tissue Responses Mimic COPD and Asthma Gene Signatures. American Journal of Respiratory Cell and Molecular Biology. PMID 34181859 DOI: 10.1165/rcmb.2020-0337OC |
0.358 |
|
| 2019 |
Dvornikov D, Zimmermann N, Khan M, Halavatyi A, Hessel E, Pöckel D, Beinke S, Pepperkok R. An ex vivo model to study response of human COPD and non-COPD small airways to infections and therapeutic interventions Erj Open Research. 5. DOI: 10.1183/23120541.Lungscienceconference-2019.Pp226 |
0.421 |
|
| 2017 |
Jackson S, Candia AF, Delaney S, Floettmann S, Wong C, Campbell JD, Kell S, Lum J, Hessel E, Traquina P, McHale M, Robinson I, Bell J, Fuhr R, Keeling D, et al. First-in-human study with the inhaled TLR9 oligonucleotide agonist AZD1419 results in interferon responses in the lung, and is safe and well-tolerated. Clinical Pharmacology and Therapeutics. PMID 29134633 DOI: 10.1002/Cpt.938 |
0.57 |
|
| 2017 |
Khan A, Southworth T, Worsley S, Sriskantharajah S, Amour A, Hessel EM, Singh D. An investigation of the anti-inflammatory effects and a potential biomarker of PI3Kδ inhibition in COPD T cells. Clinical and Experimental Pharmacology & Physiology. PMID 28508433 DOI: 10.1111/1440-1681.12784 |
0.306 |
|
| 2016 |
Davidson S, McCabe TM, Crotta S, Gad HH, Hessel EM, Beinke S, Hartmann R, Wack A. IFNλ is a potent anti-influenza therapeutic without the inflammatory side effects of IFNα treatment. Embo Molecular Medicine. PMID 27520969 DOI: 10.15252/emmm.201606413 |
0.327 |
|
| 2015 |
Calvert B, Cellek S, Maschera B, Hessel E, Hall S. Differential inflammatory response of macrophages co-cultured with epithelial cells F1000research. 6. DOI: 10.7490/F1000Research.1097444.1 |
0.307 |
|
| 2015 |
Wack A, Davidson S, Crotta S, McCabe T, Hessel E, Hartmann R. ID: 151: Unique and overlapping roles of type I and type III interferons in influenza pathology and therapy Cytokine. 76: 63. DOI: 10.1016/J.Cyto.2015.08.032 |
0.309 |
|
| 2014 |
Campbell JD, Kell SA, Kozy HM, Lum JA, Sweetwood R, Chu M, Cunningham CR, Salamon H, Lloyd CM, Coffman RL, Hessel EM. A limited CpG-containing oligodeoxynucleotide therapy regimen induces sustained suppression of allergic airway inflammation in mice Thorax. 69: 565-573. PMID 24464743 DOI: 10.1136/Thoraxjnl-2013-204605 |
0.585 |
|
| 2014 |
Palazzo S, Porter L, Juss J, Hessel E, Amour A, House D, Begg M, Chilvers E. P21 Hypoxia-induced Neutrophil Survival Is Dependent On Phosphoinositide 3-kinase (pi3-k)-mediated Signalling Thorax. 69. DOI: 10.1136/Thoraxjnl-2014-206260.171 |
0.303 |
|
| 2013 |
Sriskantharajah S, Hamblin N, Worsley S, Calver AR, Hessel EM, Amour A. Targeting phosphoinositide 3-kinase δ for the treatment of respiratory diseases. Annals of the New York Academy of Sciences. 1280: 35-9. PMID 23551101 DOI: 10.1111/nyas.12039 |
0.309 |
|
| 2013 |
Uddin S, Morley J, Hughes S, Hessel E. Characterisation of the allergic phenotype resulting from a shortened HDM challenge protocol in mice Journal of Inflammation. 10: 6. DOI: 10.1186/1476-9255-10-S1-P6 |
0.421 |
|
| 2013 |
Shaw R, Sowa M, Pedrick, Fife M, Nials A, Knowles R, Hessel E. Strategies to mimic virally induced asthmatic exacerbations: the use of rhinovirus and influenza in acute and chronic mouse models Journal of Inflammation. 10: 19. DOI: 10.1186/1476-9255-10-S1-P19 |
0.389 |
|
| 2013 |
Uddin S, Hughes S, Hessel E. Time-course of inflammation and allergic bronchoconstrictor response in a model of ovalbumin-induced rapid pulmonary inflammation in Brown Norway rats Journal of Inflammation. 10: 12. DOI: 10.1186/1476-9255-10-S1-P12 |
0.365 |
|
| 2010 |
Lloyd CM, Hessel EM. Functions of T cells in asthma: More than just TH2 cells Nature Reviews Immunology. 10: 838-848. PMID 21060320 DOI: 10.1038/nri2870 |
0.382 |
|
| 2010 |
Mionnet C, Buatois V, Kanda A, Milcent V, Fleury S, Lair D, Langelot M, Lacoeuille Y, Hessel E, Coffman R, Magnan A, Dombrowicz D, Glaichenhaus N, Julia V. CX3CR1 is required for airway inflammation by promoting T helper cell survival and maintenance in inflamed lung. Nature Medicine. 16: 1305-12. PMID 21037587 DOI: 10.1186/1479-5876-9-S2-P3 |
0.683 |
|
| 2010 |
Campbell JD, Buchmann P, Kesting S, Cunningham CR, Coffman RL, Hessel EM. Allergen-specific T cell responses to immunotherapy monitored by CD154 and intracellular cytokine expression. Clinical and Experimental Allergy : Journal of the British Society For Allergy and Clinical Immunology. 40: 1025-35. PMID 20412135 DOI: 10.1111/J.1365-2222.2010.03505.X |
0.53 |
|
| 2009 |
Campbell JD, Cho Y, Foster ML, Kanzler H, Kachura MA, Lum JA, Ratcliffe MJ, Sathe A, Leishman AJ, Bahl A, McHale M, Coffman RL, Hessel EM. CpG-containing immunostimulatory DNA sequences elicit TNF-α-dependent toxicity in rodents but not in humans Journal of Clinical Investigation. 119: 2564-2576. PMID 19726873 DOI: 10.1172/Jci38294 |
0.546 |
|
| 2009 |
Sims P, Coffman RL, Hessel EM. Biomarkers measuring the activity of Toll-like receptor ligands in clinical development programs. Methods in Molecular Biology (Clifton, N.J.). 517: 415-40. PMID 19378019 DOI: 10.1007/978-1-59745-541-1_25 |
0.547 |
|
| 2009 |
Campbell J, Buchmann P, Kesting S, King B, Coffman R, Hessel E. Successful Use of CD154 Expression and Intracellular Cytokine Staining to Monitor Changes in Allergen-Specific Th2 Cells in Peripheral Blood of Subjects in a Placebo-Controlled Study of Tolamba™, a Novel Immunotherapeutic Vaccine for Ragweed Allergies Journal of Allergy and Clinical Immunology. 123: S144-S144. DOI: 10.1016/J.Jaci.2008.12.539 |
0.5 |
|
| 2007 |
Kanzler H, Barrat FJ, Hessel EM, Coffman RL. Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists. Nature Medicine. 13: 552-9. PMID 17479101 DOI: 10.1038/Nm1589 |
0.466 |
|
| 2006 |
Gauvreau GM, Hessel EM, Boulet LP, Coffman RL, O'Byrne PM. Immunostimulatory sequences regulate interferon-inducible genes but not allergic airway responses. American Journal of Respiratory and Critical Care Medicine. 174: 15-20. PMID 16574937 DOI: 10.1164/Rccm.200601-057Oc |
0.583 |
|
| 2005 |
Hessel EM, Chu M, Lizcano JO, Chang B, Herman N, Kell SA, Wills-Karp M, Coffman RL. Immunostimulatory oligonucleotides block allergic airway inflammation by inhibiting Th2 cell activation and IgE-mediated cytokine induction. The Journal of Experimental Medicine. 202: 1563-73. PMID 16314434 DOI: 10.1084/Jem.20050631 |
0.615 |
|
| 2005 |
Coffman RL, Hessel EM. Nonhuman primate models of asthma. The Journal of Experimental Medicine. 201: 1875-9. PMID 15967818 DOI: 10.1084/Jem.20050901 |
0.546 |
|
| 2005 |
Marshall JD, Fearon KL, Higgins D, Hessel EM, Kanzler H, Abbate C, Yee P, Gregorio J, Cruz TD, Lizcano JO, Zolotorev A, McClure HM, Brasky KM, Murthy KK, Coffman RL, et al. Superior activity of the type C class of ISS in vitro and in vivo across multiple species. Dna and Cell Biology. 24: 63-72. PMID 15699627 DOI: 10.1089/Dna.2005.24.63 |
0.502 |
|
| 2005 |
Friedberg JW, Kim H, McCauley M, Hessel EM, Sims P, Fisher DC, Nadler LM, Coffman RL, Freedman AS. Combination immunotherapy with a CpG oligonucleotide (1018 ISS) and rituximab in patients with non-Hodgkin lymphoma: increased interferon-alpha/beta-inducible gene expression, without significant toxicity. Blood. 105: 489-95. PMID 15358617 DOI: 10.1182/Blood-2004-06-2156 |
0.521 |
|
| 2003 |
Marshall JD, Hessel EM, Gregorio J, Abbate C, Yee P, Chu M, Van Nest G, Coffman RL, Fearon KL. Novel chimeric immunomodulatory compounds containing short CpG oligodeoxyribonucleotides have differential activities in human cells. Nucleic Acids Research. 31: 5122-33. PMID 12930963 DOI: 10.1093/Nar/Gkg700 |
0.495 |
|
| 2002 |
Julia V, Hessel EM, Malherbe L, Glaichenhaus N, O'Garra A, Coffman RL. A restricted subset of dendritic cells captures airborne antigens and remains able to activate specific T cells long after antigen exposure. Immunity. 16: 271-83. PMID 11869687 DOI: 10.1016/S1074-7613(02)00276-5 |
0.683 |
|
| 2001 |
Scheerens H, Hessel E, Waal-Malefyt Rd, Leach MW, Rennick D. Characterization of chemokines and chemokine receptors in two murine models of inflammatory bowel disease: IL-10-/- mice and Rag-2-/- mice reconstituted with CD4+CD45RBhigh T cells. European Journal of Immunology. 31: 1465-1474. PMID 11465103 DOI: 10.1002/1521-4141(200105)31:5<1465::Aid-Immu1465>3.0.Co;2-E |
0.4 |
|
| 1998 |
Gochuico BR, Miranda KM, Hessel EM, De Bie JJ, Van Oosterhout AJM, Cruikshank WW, Fine A. Airway epithelial Fas ligand expression: potential role in modulating bronchial inflammation. American Journal of Physiology. Lung Cellular and Molecular Physiology. 274: L444-L449. PMID 29591289 DOI: 10.1152/ajplung.1998.274.3.L444 |
0.373 |
|
| 1996 |
Hessel EM, Van Oosterhout AJ, Hofstra CL, De Bie JJ, Garssen J, Van Loveren H, Verheyen AK, Savelkoul HF, Nijkamp FP. Bronchoconstriction and airway hyperresponsiveness after ovalbumin inhalation in sensitized mice. European Journal of Pharmacology. 293: 401-12. PMID 8748694 DOI: 10.1016/0926-6917(95)90061-6 |
0.432 |
|
| 1996 |
Blyth DI, Pedrick MS, Savage TJ, Hessel EM, Fattah D. Lung inflammation and epithelial changes in a murine model of atopic asthma. American Journal of Respiratory Cell and Molecular Biology. 14: 425-38. PMID 8624247 DOI: 10.1165/AJRCMB.14.5.8624247 |
0.416 |
|
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