Eric W. Schmidt, PhD - Publications

Affiliations: 
2002- Department of Medicinal Chemistry University of Utah, Salt Lake City, UT 

110 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Lin Z, Agarwal V, Cong Y, Pomponi SA, Schmidt EW. Short macrocyclic peptides in sponge genomes. Proceedings of the National Academy of Sciences of the United States of America. 121: e2314383121. PMID 38442178 DOI: 10.1073/pnas.2314383121  0.309
2023 Li F, Lin Z, Krug PJ, Catrow JL, Cox JE, Schmidt EW. Animal FAS-like polyketide synthases produce diverse polypropionates. Proceedings of the National Academy of Sciences of the United States of America. 120: e2305575120. PMID 37695909 DOI: 10.1073/pnas.2305575120  0.307
2022 Nguyen NA, Cong Y, Hurrell RC, Arias N, Garg N, Puri AW, Schmidt EW, Agarwal V. A Silent Biosynthetic Gene Cluster from a Methanotrophic Bacterium Potentiates Discovery of a Substrate Promiscuous Proteusin Cyclodehydratase. Acs Chemical Biology. PMID 35666841 DOI: 10.1021/acschembio.2c00251  0.36
2022 Li F, Lin Z, Torres JP, Hill EA, Li D, Townsend CA, Schmidt EW. Sea Urchin Polyketide Synthase SpPks1 Produces the Naphthalene Precursor to Echinoderm Pigments. Journal of the American Chemical Society. 144: 9363-9371. PMID 35588530 DOI: 10.1021/jacs.2c01416  0.713
2022 Zheng Y, Cong Y, Schmidt EW, Nair SK. Catalysts for the Enzymatic Lipidation of Peptides. Accounts of Chemical Research. PMID 35442036 DOI: 10.1021/acs.accounts.2c00108  0.31
2021 Nguyen NA, Lin Z, Mohanty I, Garg N, Schmidt EW, Agarwal V. An Obligate Peptidyl Brominase Underlies the Discovery of Highly Distributed Biosynthetic Gene Clusters in Marine Sponge Microbiomes. Journal of the American Chemical Society. PMID 34213321 DOI: 10.1021/jacs.1c03474  0.403
2021 Lin Z, Torres JP, Watkins M, Paguigan N, Niu C, Imperial JS, Tun J, Safavi-Hemami H, Finol-Urdaneta RK, Neves JLB, Espino S, Karthikeyan M, Olivera BM, Schmidt EW. Non-Peptidic Small Molecule Components from Cone Snail Venoms. Frontiers in Pharmacology. 12: 655981. PMID 34054536 DOI: 10.3389/fphar.2021.655981  0.313
2021 Morinaka BI, Schmidt EW, Purushothaman M, Sarkar S, Morita M, Gugger M. Genome mining based discovery of the cyclic peptide tolypamide and TolF, a Ser/Thr forward O-prenyltransferase. Angewandte Chemie (International Ed. in English). PMID 33586286 DOI: 10.1002/anie.202015975  0.355
2020 Sarkar S, Gu W, Schmidt EW. Expanding the chemical space of synthetic cyclic peptides using a promiscuous macrocyclase from prenylagaramide biosynthesis. Acs Catalysis. 10: 7146-7153. PMID 33457065 DOI: 10.1021/Acscatal.0C00623  0.463
2020 Montalbán-López M, Scott TA, Ramesh S, Rahman IR, van Heel AJ, Viel JH, Bandarian V, Dittmann E, Genilloud O, Goto Y, Grande Burgos MJ, Hill C, Kim S, Koehnke J, Latham JA, ... ... Schmidt EW, et al. New developments in RiPP discovery, enzymology and engineering. Natural Product Reports. PMID 32935693 DOI: 10.1039/D0Np00027B  0.429
2020 Altamia MA, Lin Z, Trindade-Silva AE, Uy ID, Shipway JR, Wilke DV, Concepcion GP, Distel DL, Schmidt EW, Haygood MG. Secondary Metabolism in the Gill Microbiota of Shipworms (Teredinidae) as Revealed by Comparison of Metagenomes and Nearly Complete Symbiont Genomes. Msystems. 5. PMID 32606027 DOI: 10.1128/mSystems.00261-20  0.347
2020 Youssef DTA, Almagthali H, Shaala LA, Schmidt EW. Secondary Metabolites of the Genus : A Comprehensive Review of Chemical Diversity and Pharmacological Properties. Marine Drugs. 18. PMID 32545321 DOI: 10.3390/Md18060307  0.411
2020 Torres JP, Lin Z, Winter JM, Krug PJ, Schmidt EW. Animal biosynthesis of complex polyketides in a photosynthetic partnership. Nature Communications. 11: 2882. PMID 32513940 DOI: 10.1038/S41467-020-16376-5  0.39
2020 Larson EC, Lim AL, Pond CD, Craft M, Čavužić M, Waldrop GL, Schmidt EW, Barrows LR. Pyrrolocin C and equisetin inhibit bacterial acetyl-CoA carboxylase. Plos One. 15: e0233485. PMID 32470050 DOI: 10.1371/Journal.Pone.0233485  0.352
2020 Thapa HR, Lin Z, Yi D, Smith JE, Schmidt EW, Agarwal V. Genetic and biochemical reconstitution of bromoform biosynthesis in Asparagopsis lends insights into seaweed ROS enzymology. Acs Chemical Biology. PMID 32453942 DOI: 10.1021/Acschembio.0C00299  0.408
2020 O'Connor RM, Nepveux V FJ, Abenoja J, Bowden G, Reis P, Beaushaw J, Bone Relat RM, Driskell I, Gimenez F, Riggs MW, Schaefer DA, Schmidt EW, Lin Z, Distel DL, Clardy J, et al. A symbiotic bacterium of shipworms produces a compound with broad spectrum anti-apicomplexan activity. Plos Pathogens. 16: e1008600. PMID 32453775 DOI: 10.1371/Journal.Ppat.1008600  0.336
2020 Torres JP, Lin Z, Fenton DS, Leavitt LU, Niu C, Lam PY, Robes JM, Peterson RT, Concepcion GP, Haygood MG, Olivera BM, Schmidt EW. Boholamide A, an APD-Class, Hypoxia-Selective Cyclodepsipeptide. Journal of Natural Products. PMID 32186874 DOI: 10.1021/Acs.Jnatprod.0C00038  0.373
2020 Miller BW, Torres JP, Tun JO, Flores MS, Forteza I, Rosenberg G, Haygood MG, Schmidt EW, Concepcion GP. Synergistic anti-methicillin-resistant Staphylococcus aureus (MRSA) activity and absolute stereochemistry of 7,8-dideoxygriseorhodin C. The Journal of Antibiotics. PMID 31992865 DOI: 10.1038/S41429-019-0275-8  0.315
2019 Torres JP, Schmidt EW. The biosynthetic diversity of the animal world. The Journal of Biological Chemistry. PMID 31604818 DOI: 10.1074/Jbc.Rev119.006130  0.452
2019 Lin Z, Kakule TB, Reilly CA, Beyhan S, Schmidt EW. Secondary Metabolites of Onygenales Fungi Exemplified by Aioliomyces pyridodomos. Journal of Natural Products. PMID 31155876 DOI: 10.1021/Acs.Jnatprod.9B00121  0.418
2018 Lin Z, Phadke S, Lu Z, Beyhan S, Abdel Aziz MH, Reilly C, Schmidt EW. Onydecalins, Fungal Polyketides with Anti- Histoplasma and Anti-TRP Activity. Journal of Natural Products. PMID 30507122 DOI: 10.1021/Acs.Jnatprod.7B01067  0.36
2018 Gu W, Sardar D, Pierce E, Schmidt EW. Roads to Rome: Role of Multiple Cassettes in Cyanobactin RiPP Biosynthesis. Journal of the American Chemical Society. PMID 30387998 DOI: 10.1021/Jacs.8B09328  0.454
2018 Wozniak CE, Lin Z, Schmidt EW, Hughes KT, Liou TG. Thailandamide: a fatty acid synthesis antibiotic that is co-expressed with a resistant target gene. Antimicrobial Agents and Chemotherapy. PMID 29914944 DOI: 10.1128/Aac.00463-18  0.347
2018 Gu W, Dong SH, Sarkar S, Nair SK, Schmidt EW. The Biochemistry and Structural Biology of Cyanobactin Pathways: Enabling Combinatorial Biosynthesis. Methods in Enzymology. 604: 113-163. PMID 29779651 DOI: 10.1016/Bs.Mie.2018.03.002  0.431
2018 Morita M, Hao Y, Jokela J, Sardar D, Lin Z, Sivonen K, Nair SK, Schmidt EW. Posttranslational Tyrosine Geranylation in Cyanobactin Biosynthesis. Journal of the American Chemical Society. PMID 29701961 DOI: 10.1021/Jacs.8B03137  0.432
2018 Morita M, Schmidt EW. Parallel lives of symbionts and hosts: chemical mutualism in marine animals. Natural Product Reports. 35: 357-378. PMID 29441375 DOI: 10.1039/C7Np00053G  0.405
2018 Smith TE, Pond CD, Pierce E, Harmer ZP, Kwan J, Zachariah MM, Harper MK, Wyche TP, Matainaho TK, Bugni TS, Barrows LR, Ireland CM, Schmidt EW. Accessing chemical diversity from the uncultivated symbionts of small marine animals. Nature Chemical Biology. PMID 29291350 DOI: 10.1038/Nchembio.2537  0.744
2018 Estrada P, Morita M, Hao Y, Schmidt EW, Nair SK. A Single Amino Acid Switch Alters the Isoprene Donor Specificity in Ribosomally Synthesized and Post-Translationally Modified Peptide Prenyltransferases Journal of the American Chemical Society. 140: 8124-8127. DOI: 10.2210/Pdb6Pgm/Pdb  0.34
2017 Torres JP, Tianero MD, Robes JMD, Kwan JC, Biggs JS, Concepcion GP, Olivera BM, Haygood MG, Schmidt EW. Stenotrophomonas-like bacteria are widespread symbionts in cone snail venom ducts. Applied and Environmental Microbiology. PMID 28986377 DOI: 10.1128/Aem.01418-17  0.727
2017 Gu W, Schmidt EW. Three Principles of Diversity-Generating Biosynthesis. Accounts of Chemical Research. PMID 28891639 DOI: 10.1021/Acs.Accounts.7B00330  0.511
2017 Olivera BM, Raghuraman S, Schmidt EW, Safavi-Hemami H. Linking neuroethology to the chemical biology of natural products: interactions between cone snails and their fish prey, a case study. Journal of Comparative Physiology. a, Neuroethology, Sensory, Neural, and Behavioral Physiology. PMID 28551870 DOI: 10.1007/S00359-017-1183-7  0.443
2017 Distel DL, Altamia MA, Lin Z, Shipway JR, Han A, Forteza I, Antemano R, Limbaco MGJP, Tebo AG, Dechavez R, Albano J, Rosenberg G, Concepcion GP, Schmidt EW, Haygood MG. Discovery of chemoautotrophic symbiosis in the giant shipworm Kuphus polythalamia (Bivalvia: Teredinidae) extends wooden-steps theory. Proceedings of the National Academy of Sciences of the United States of America. PMID 28416684 DOI: 10.1073/Pnas.1620470114  0.313
2017 Agarwal V, Blanton JM, Podell S, Taton A, Schorn MA, Busch J, Lin Z, Schmidt EW, Jensen PR, Paul VJ, Biggs JS, Golden JW, Allen EE, Moore BS. Metagenomic discovery of polybrominated diphenyl ether biosynthesis by marine sponges. Nature Chemical Biology. PMID 28319100 DOI: 10.1038/Nchembio.2330  0.411
2017 Sardar D, Hao Y, Lin Z, Morita M, Nair SK, Schmidt EW. Enzymatic N- and C-protection in cyanobactin RiPP natural products. Journal of the American Chemical Society. PMID 28195477 DOI: 10.1021/Jacs.6B12872  0.446
2017 Zhang S, Qiu Y, Kakule TB, Lu Z, Xu F, Lamb JG, Reilly CA, Zheng Y, Sham SW, Wang W, Xuan L, Schmidt EW, Zhan J. Identification of Cyclic Depsipeptides and Their Dedicated Synthetase from Hapsidospora irregularis. Journal of Natural Products. PMID 28106998 DOI: 10.1021/Acs.Jnatprod.6B00808  0.317
2017 Aihara K, Inokuma T, Jichu T, Lin Z, Fu F, Yamaoka K, Shigenaga A, Hutchins DA, Schmidt EW, Otaka A. Cysteine-Free Intramolecular Ligation of N-Sulfanylethylanilide Peptide Using 4-Mercaptobenzylphosphonic Acid: Synthesis of Cyclic Peptide Trichamide Synlett. 28: 1944-1949. DOI: 10.1055/S-0036-1589055  0.366
2016 Hao Y, Pierce E, Roe D, Morita M, McIntosh JA, Agarwal V, Cheatham TE, Schmidt EW, Nair SK. Molecular basis for the broad substrate selectivity of a peptide prenyltransferase. Proceedings of the National Academy of Sciences of the United States of America. PMID 27872314 DOI: 10.1073/Pnas.1609869113  0.399
2016 Sardar D, Tianero MD, Schmidt EW. Directing Biosynthesis: Practical Supply of Natural and Unnatural Cyanobactins. Methods in Enzymology. 575: 1-20. PMID 27417922 DOI: 10.1016/Bs.Mie.2016.02.012  0.46
2016 Lin Z, Torres JP, Tianero MD, Kwan JC, Schmidt EW. Origin of chemical diversity in the Prochloron-tunicate symbiosis. Applied and Environmental Microbiology. PMID 27037119 DOI: 10.1128/AEM.00860-16  0.654
2016 Tianero MD, Pierce E, Raghuraman S, Sardar D, McIntosh JA, Heemstra JR, Schonrock Z, Covington BC, Maschek JA, Cox JE, Bachmann BO, Olivera BM, Ruffner DE, Schmidt EW. Metabolic model for diversity-generating biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. PMID 26831074 DOI: 10.1073/Pnas.1525438113  0.631
2016 Sardar D, Schmidt EW. Combinatorial biosynthesis of RiPPs: docking with marine life. Current Opinion in Chemical Biology. 31: 15-21. PMID 26709871 DOI: 10.1016/J.Cbpa.2015.11.016  0.466
2015 Neves JL, Lin Z, Imperial JS, Antunes A, Vasconcelos V, Olivera BM, Schmidt EW. Small Molecules in the Cone Snail Arsenal. Organic Letters. PMID 26421741 DOI: 10.1021/Acs.Orglett.5B02389  0.349
2015 Sardar D, Lin Z, Schmidt EW. Modularity of RiPP Enzymes Enables Designed Synthesis of Decorated Peptides. Chemistry & Biology. PMID 26165156 DOI: 10.1016/J.Chembiol.2015.06.014  0.427
2015 Schmidt EW. The secret to a successful relationship: lasting chemistry between ascidians and their symbiotic bacteria. Invertebrate Biology : a Quarterly Journal of the American Microscopical Society and the Division of Invertebrate Zoology/Asz. 134: 88-102. PMID 25937788 DOI: 10.1111/Ivb.12071  0.429
2015 Schmidt EW. Natural products: Hunting microbial metabolites. Nature Chemistry. 7: 375-6. PMID 25901811 DOI: 10.1038/Nchem.2252  0.42
2015 Kakule TB, Zhang S, Zhan J, Schmidt EW. Biosynthesis of the tetramic acids Sch210971 and Sch210972. Organic Letters. 17: 2295-7. PMID 25885659 DOI: 10.1021/Acs.Orglett.5B00715  0.375
2015 Teichert RW, Schmidt EW, Olivera BM. Constellation pharmacology: a new paradigm for drug discovery. Annual Review of Pharmacology and Toxicology. 55: 573-89. PMID 25562646 DOI: 10.1146/Annurev-Pharmtox-010814-124551  0.34
2015 Kakule TB, Jadulco RC, Koch M, Janso JE, Barrows LR, Schmidt EW. Native promoter strategy for high-yielding synthesis and engineering of fungal secondary metabolites. Acs Synthetic Biology. 4: 625-33. PMID 25226362 DOI: 10.1021/Sb500296P  0.374
2015 Tianero MD, Kwan JC, Wyche TP, Presson AP, Koch M, Barrows LR, Bugni TS, Schmidt EW. Species specificity of symbiosis and secondary metabolism in ascidians. The Isme Journal. 9: 615-28. PMID 25171330 DOI: 10.1038/Ismej.2014.152  0.679
2015 Ruffner DE, Schmidt EW, Heemstra JR. Assessing the combinatorial potential of the RiPP cyanobactin tru pathway. Acs Synthetic Biology. 4: 482-92. PMID 25140729 DOI: 10.1021/Sb500267D  0.409
2015 Sardar D, Pierce E, McIntosh JA, Schmidt EW. Recognition sequences and substrate evolution in cyanobactin biosynthesis. Acs Synthetic Biology. 4: 167-76. PMID 24625112 DOI: 10.1021/Sb500019B  0.444
2015 Haygood M, Altamia M, Elshahawi S, Han A, Lin Z, Betcher M, O'Connor R, Sandy M, Trinidade-Silva A, Butler A, Schmidt E, Concepcion G, Distel D. Versatile bacterial symbionts of shipworms contribute to wood digestion, fix nitrogen and produce secondary metabolites Planta Medica. 81. DOI: 10.1055/S-0035-1556140  0.39
2014 Kakule TB, Lin Z, Schmidt EW. Combinatorialization of fungal polyketide synthase-peptide synthetase hybrid proteins. Journal of the American Chemical Society. 136: 17882-90. PMID 25436464 DOI: 10.1021/Ja511087P  0.463
2014 Jadulco RC, Koch M, Kakule TB, Schmidt EW, Orendt A, He H, Janso JE, Carter GT, Larson EC, Pond C, Matainaho TK, Barrows LR. Isolation of pyrrolocins A-C: cis- and trans-decalin tetramic acid antibiotics from an endophytic fungal-derived pathway. Journal of Natural Products. 77: 2537-44. PMID 25351193 DOI: 10.1021/Np500617U  0.383
2014 Lin Z, Koch M, Abdel Aziz MH, Galindo-Murillo R, Tianero MD, Cheatham TE, Barrows LR, Reilly CA, Schmidt EW. Oxazinin A, a pseudodimeric natural product of mixed biosynthetic origin from a filamentous fungus. Organic Letters. 16: 4774-7. PMID 25188821 DOI: 10.1021/Ol502227X  0.347
2014 Kwan JC, Tianero MD, Donia MS, Wyche TP, Bugni TS, Schmidt EW. Host control of symbiont natural product chemistry in cryptic populations of the tunicate Lissoclinum patella. Plos One. 9: e95850. PMID 24788869 DOI: 10.1371/Journal.Pone.0095850  0.799
2014 Lin Z, Zachariah MM, Marett L, Hughen RW, Teichert RW, Concepcion GP, Haygood MG, Olivera BM, Light AR, Schmidt EW. Griseorhodins D-F, neuroactive intermediates and end products of post-PKS tailoring modification in Griseorhodin biosynthesis. Journal of Natural Products. 77: 1224-30. PMID 24786728 DOI: 10.1021/Np500155D  0.356
2014 Lin Z, Koch M, Pond CD, Mabeza G, Seronay RA, Concepcion GP, Barrows LR, Olivera BM, Schmidt EW. Structure and activity of lobophorins from a turrid mollusk-associated Streptomyces sp. The Journal of Antibiotics. 67: 121-6. PMID 24220110 DOI: 10.1038/Ja.2013.115  0.331
2014 Adnani N, Ellis GA, Wyche TP, Bugni TS, Kwan JC, Schmidt EW. Emerging Trends for Stimulating the Discovery of Natural Products Natural Products Analysis: Instrumentation, Methods, and Applications. 115-161. DOI: 10.1002/9781118876015.ch5  0.627
2013 Kwan JC, Schmidt EW. Bacterial endosymbiosis in a chordate host: long-term co-evolution and conservation of secondary metabolism. Plos One. 8: e80822. PMID 24324632 DOI: 10.1371/Journal.Pone.0080822  0.68
2013 Lin Z, Marett L, Hughen RW, Flores M, Forteza I, Ammon MA, Concepcion GP, Espino S, Olivera BM, Rosenberg G, Haygood MG, Light AR, Schmidt EW. Neuroactive diol and acyloin metabolites from cone snail-associated bacteria. Bioorganic & Medicinal Chemistry Letters. 23: 4867-9. PMID 23880542 DOI: 10.1016/J.Bmcl.2013.06.088  0.331
2013 Kakule TB, Sardar D, Lin Z, Schmidt EW. Two related pyrrolidinedione synthetase loci in Fusarium heterosporum ATCC 74349 produce divergent metabolites. Acs Chemical Biology. 8: 1549-57. PMID 23614392 DOI: 10.1021/Cb400159F  0.383
2013 McIntosh JA, Lin Z, Tianero MD, Schmidt EW. Aestuaramides, a natural library of cyanobactin cyclic peptides resulting from isoprene-derived Claisen rearrangements. Acs Chemical Biology. 8: 877-83. PMID 23411099 DOI: 10.1021/Cb300614C  0.442
2013 Lin Z, Torres JP, Ammon MA, Marett L, Teichert RW, Reilly CA, Kwan JC, Hughen RW, Flores M, Tianero MD, Peraud O, Cox JE, Light AR, Villaraza AJ, Haygood MG, ... ... Schmidt EW, et al. A bacterial source for mollusk pyrone polyketides. Chemistry & Biology. 20: 73-81. PMID 23352141 DOI: 10.1016/J.Chembiol.2012.10.019  0.697
2013 Elshahawi SI, Trindade-Silva AE, Hanora A, Han AW, Flores MS, Vizzoni V, Schrago CG, Soares CA, Concepcion GP, Distel DL, Schmidt EW, Haygood MG. Boronated tartrolon antibiotic produced by symbiotic cellulose-degrading bacteria in shipworm gills. Proceedings of the National Academy of Sciences of the United States of America. 110: E295-304. PMID 23288898 DOI: 10.1073/Pnas.1213892110  0.408
2013 Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, ... ... Schmidt EW, et al. Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Natural Product Reports. 30: 108-60. PMID 23165928 DOI: 10.1039/C2Np20085F  0.77
2013 Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, ... ... Schmidt EW, et al. Erratum: Ribosomally synthesized and post-translationally modified peptide natural products: Overview and recommendations for a universal nomenclature (Natural Product Reports (2013) 30 (108-160) DOI:10.1039/C2NP20085F) Natural Product Reports. 30: 1568-1568. DOI: 10.1039/C3Np90040A  0.646
2012 Schmidt EW. Decoding and recoding the ribosomal peptide universe. Chemistry & Biology. 19: 1501-2. PMID 23261594 DOI: 10.1016/J.Chembiol.2012.12.002  0.441
2012 Kwan JC, Donia MS, Han AW, Hirose E, Haygood MG, Schmidt EW. Genome streamlining and chemical defense in a coral reef symbiosis. Proceedings of the National Academy of Sciences of the United States of America. 109: 20655-60. PMID 23185008 DOI: 10.1073/Pnas.1213820109  0.786
2012 Agarwal V, Pierce E, McIntosh J, Schmidt EW, Nair SK. Structures of cyanobactin maturation enzymes define a family of transamidating proteases. Chemistry & Biology. 19: 1411-22. PMID 23177196 DOI: 10.1016/J.Chembiol.2012.09.012  0.39
2012 Lin Z, Falkinham JO, Tawfik KA, Jeffs P, Bray B, Dubay G, Cox JE, Schmidt EW. Burkholdines from Burkholderia ambifaria: antifungal agents and possible virulence factors. Journal of Natural Products. 75: 1518-23. PMID 22988812 DOI: 10.1021/Np300108U  0.347
2012 Hou Y, Tianero MD, Kwan JC, Wyche TP, Michel CR, Ellis GA, Vazquez-Rivera E, Braun DR, Rose WE, Schmidt EW, Bugni TS. Structure and biosynthesis of the antibiotic bottromycin D. Organic Letters. 14: 5050-3. PMID 22984777 DOI: 10.1021/Ol3022758  0.648
2012 Kwan JC, Schmidt EW. Cleaning up polyketide synthases Chemistry and Biology. 19: 309-311. PMID 22444584 DOI: 10.1016/J.Chembiol.2012.03.003  0.641
2012 Lin Z, Flores M, Forteza I, Henriksen NM, Concepcion GP, Rosenberg G, Haygood MG, Olivera BM, Light AR, Cheatham TE, Schmidt EW. Totopotensamides, polyketide-cyclic peptide hybrids from a mollusk-associated bacterium Streptomyces sp. Journal of Natural Products. 75: 644-9. PMID 22439622 DOI: 10.1021/Np200886X  0.397
2012 Schmidt EW, Donia MS, McIntosh JA, Fricke WF, Ravel J. Origin and variation of tunicate secondary metabolites. Journal of Natural Products. 75: 295-304. PMID 22233390 DOI: 10.1021/Np200665K  0.719
2012 Tianero MD, Donia MS, Young TS, Schultz PG, Schmidt EW. Ribosomal route to small-molecule diversity. Journal of the American Chemical Society. 134: 418-25. PMID 22107593 DOI: 10.1021/Ja208278K  0.733
2011 Donia MS, Fricke WF, Partensky F, Cox J, Elshahawi SI, White JR, Phillippy AM, Schatz MC, Piel J, Haygood MG, Ravel J, Schmidt EW. Complex microbiome underlying secondary and primary metabolism in the tunicate-Prochloron symbiosis. Proceedings of the National Academy of Sciences of the United States of America. 108: E1423-32. PMID 22123943 DOI: 10.1073/Pnas.1111712108  0.727
2011 McIntosh JA, Donia MS, Nair SK, Schmidt EW. Enzymatic basis of ribosomal peptide prenylation in cyanobacteria. Journal of the American Chemical Society. 133: 13698-705. PMID 21766822 DOI: 10.1021/Ja205458H  0.742
2011 Donia MS, Ruffner DE, Cao S, Schmidt EW. Accessing the hidden majority of marine natural products through metagenomics. Chembiochem : a European Journal of Chemical Biology. 12: 1230-6. PMID 21542088 DOI: 10.1002/Cbic.201000780  0.765
2011 Donia MS, Schmidt EW. Linking chemistry and genetics in the growing cyanobactin natural products family. Chemistry & Biology. 18: 508-19. PMID 21513887 DOI: 10.1016/J.Chembiol.2011.01.019  0.764
2011 Donia MS, Fricke WF, Ravel J, Schmidt EW. Variation in tropical reef symbiont metagenomes defined by secondary metabolism. Plos One. 6: e17897. PMID 21445351 DOI: 10.1371/Journal.Pone.0017897  0.731
2010 Schmidt EW, Donia MS. Life in cellulose houses: symbiotic bacterial biosynthesis of ascidian drugs and drug leads. Current Opinion in Biotechnology. 21: 827-33. PMID 21050742 DOI: 10.1016/J.Copbio.2010.10.006  0.709
2010 Lin Z, Antemano RR, Hughen RW, Tianero MD, Peraud O, Haygood MG, Concepcion GP, Olivera BM, Light A, Schmidt EW. Pulicatins A-E, neuroactive thiazoline metabolites from cone snail-associated bacteria. Journal of Natural Products. 73: 1922-6. PMID 21028889 DOI: 10.1021/Np100588C  0.351
2010 McIntosh JA, Robertson CR, Agarwal V, Nair SK, Bulaj GW, Schmidt EW. Circular logic: nonribosomal peptide-like macrocyclization with a ribosomal peptide catalyst. Journal of the American Chemical Society. 132: 15499-501. PMID 20961047 DOI: 10.1021/Ja1067806  0.389
2010 Schmidt EW. The hidden diversity of ribosomal peptide natural products. Bmc Biology. 8: 83. PMID 20594290 DOI: 10.1186/1741-7007-8-83  0.499
2010 McIntosh JA, Schmidt EW. Marine molecular machines: heterocyclization in cyanobactin biosynthesis. Chembiochem : a European Journal of Chemical Biology. 11: 1413-21. PMID 20540059 DOI: 10.1002/Cbic.201000196  0.454
2010 McIntosh JA, Donia MS, Schmidt EW. Insights into heterocyclization from two highly similar enzymes. Journal of the American Chemical Society. 132: 4089-91. PMID 20210311 DOI: 10.1021/Ja9107116  0.711
2010 SCHMIDT EW, FAULKNER DJ. ChemInform Abstract: Microsclerodermins C-E, Antifungal Cyclic Peptides from the Lithistid Marine Sponges Theonella sp. and Microscleroderma sp. Cheminform. 29: no-no. DOI: 10.1002/CHIN.199826240  0.457
2009 Brady SF, Simmons L, Kim JH, Schmidt EW. Metagenomic approaches to natural products from free-living and symbiotic organisms. Natural Product Reports. 26: 1488-503. PMID 19844642 DOI: 10.1039/B817078A  0.438
2009 Peraud O, Biggs JS, Hughen RW, Light AR, Concepcion GP, Olivera BM, Schmidt EW. Microhabitats within venomous cone snails contain diverse actinobacteria. Applied and Environmental Microbiology. 75: 6820-6. PMID 19749071 DOI: 10.1128/Aem.01238-09  0.435
2009 McIntosh JA, Donia MS, Schmidt EW. Ribosomal peptide natural products: bridging the ribosomal and nonribosomal worlds. Natural Product Reports. 26: 537-59. PMID 19642421 DOI: 10.1039/B714132G  0.756
2009 Yang JC, Madupu R, Durkin AS, Ekborg NA, Pedamallu CS, Hostetler JB, Radune D, Toms BS, Henrissat B, Coutinho PM, Schwarz S, Field L, Trindade-Silva AE, Soares CA, Elshahawi S, ... ... Schmidt EW, et al. The complete genome of Teredinibacter turnerae T7901: an intracellular endosymbiont of marine wood-boring bivalves (shipworms). Plos One. 4: e6085. PMID 19568419 DOI: 10.1371/Journal.Pone.0006085  0.348
2009 Schmidt EW, Donia MS. Chapter 23. Cyanobactin ribosomally synthesized peptides--a case of deep metagenome mining. Methods in Enzymology. 458: 575-96. PMID 19374999 DOI: 10.1016/S0076-6879(09)04823-X  0.757
2009 Lee J, McIntosh J, Hathaway BJ, Schmidt EW. Using marine natural products to discover a protease that catalyzes peptide macrocyclization of diverse substrates. Journal of the American Chemical Society. 131: 2122-4. PMID 19166292 DOI: 10.1021/Ja8092168  0.436
2008 Schmidt EW. Trading molecules and tracking targets in symbiotic interactions. Nature Chemical Biology. 4: 466-73. PMID 18641627 DOI: 10.1038/Nchembio.101  0.376
2008 Donia MS, Ravel J, Schmidt EW. A global assembly line for cyanobactins. Nature Chemical Biology. 4: 341-3. PMID 18425112 DOI: 10.1038/Nchembio.84  0.717
2006 Donia MS, Hathaway BJ, Sudek S, Haygood MG, Rosovitz MJ, Ravel J, Schmidt EW. Natural combinatorial peptide libraries in cyanobacterial symbionts of marine ascidians. Nature Chemical Biology. 2: 729-35. PMID 17086177 DOI: 10.1038/Nchembio829  0.765
2006 Sudek S, Haygood MG, Youssef DT, Schmidt EW. Structure of trichamide, a cyclic peptide from the bloom-forming cyanobacterium Trichodesmium erythraeum, predicted from the genome sequence. Applied and Environmental Microbiology. 72: 4382-7. PMID 16751554 DOI: 10.1128/Aem.00380-06  0.426
2005 Schmidt EW. From chemical structure to environmental biosynthetic pathways: navigating marine invertebrate-bacteria associations. Trends in Biotechnology. 23: 437-40. PMID 16038996 DOI: 10.1016/J.Tibtech.2005.07.002  0.441
2005 Schmidt EW, Nelson JT, Rasko DA, Sudek S, Eisen JA, Haygood MG, Ravel J. Patellamide A and C biosynthesis by a microcin-like pathway in Prochloron didemni, the cyanobacterial symbiont of Lissoclinum patella. Proceedings of the National Academy of Sciences of the United States of America. 102: 7315-20. PMID 15883371 DOI: 10.1073/Pnas.0501424102  0.462
2005 Sims JW, Fillmore JP, Warner DD, Schmidt EW. Equisetin biosynthesis in Fusarium heterosporum. Chemical Communications (Cambridge, England). 186-8. PMID 15724180 DOI: 10.1039/B413523G  0.316
2004 Schmidt EW, Sudek S, Haygood MG. Genetic evidence supports secondary metabolic diversity in Prochloron spp., the cyanobacterial symbiont of a tropical ascidian. Journal of Natural Products. 67: 1341-5. PMID 15332852 DOI: 10.1021/Np049948N  0.438
2004 Schmidt EW, Raventos-Suarez C, Bifano M, Menendez AT, Fairchild CR, Faulkner DJ. Scleritodermin A, a cytotoxic cyclic peptide from the lithistid sponge Scleritoderma nodosum. Journal of Natural Products. 67: 475-8. PMID 15043437 DOI: 10.1021/Np034035Z  0.53
2004 Schmidt EW, Nelson JT, Fillmore JP. Synthesis of tyrosine derivatives for saframycin MX1 biosynthetic studies Tetrahedron Letters. 45: 3921-3924. DOI: 10.1016/J.Tetlet.2004.03.112  0.39
2001 Hitchman TS, Schmidt EW, Trail F, Rarick MD, Linz JE, Townsend CA. Hexanoate synthase, a specialized type I fatty acid synthase in aflatoxin B1 biosynthesis. Bioorganic Chemistry. 29: 293-307. PMID 16256699 DOI: 10.1006/Bioo.2001.1216  0.551
2000 Schmidt EW, Obraztsova AY, Davidson SK, Faulkner DJ, Haygood MG. Identification of the antifungal peptide-containing symbiont of the marine sponge Theonella swinhoei as a novel δ-proteobacterium, "Candidatus Entotheonella palauensis" Marine Biology. 136: 969-977. DOI: 10.1007/S002270000273  0.387
1998 Schmidt EW, Bewley CA, Faulkner DJ. Theopalauamide, a Bicyclic Glycopeptide from Filamentous Bacterial Symbionts of the Lithistid Sponge Theonella swinhoei from Palau and Mozambique Journal of Organic Chemistry. 63: 1254-1258. DOI: 10.1021/Jo9718455  0.578
1998 Schmidt EW, Faulkner DJ. Microsclerodermins C-E, antifungal cyclic peptides from the lithistid marine sponges Theonella sp. and Microscleroderma sp Tetrahedron. 54: 3043-3056. DOI: 10.1016/S0040-4020(98)00054-4  0.389
1997 Schmidt EW, Harper MK, Faulkner DJ. Mozamides A and B, cyclic peptides from a theonellid sponge from Mozambique Journal of Natural Products. 60: 779-782. DOI: 10.1021/Np970195X  0.367
1995 Schmidt EW, Harper MK, Faulkner DJ. Makaluvamines H-M and damirone C from the pohnpeian sponge Zyzzya fuliginosa. Journal of Natural Products. 58: 1861-7. PMID 8691207  0.346
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