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Daniel Santi - Publications

Affiliations: 
Pharmacy University of California, San Francisco, San Francisco, CA 
Area:
Medicinal Chemistry
Website:
https://profiles.ucsf.edu/daniel.santi
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27 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
1999 Stout TJ, Tondi D, Rinaldi M, Barlocco D, Pecorari P, Santi DV, Kuntz ID, Stroud RM, Shoichet BK, Costi MP. Structure-based design of inhibitors specific for bacterial thymidylate synthase. Biochemistry. 38: 1607-17. PMID 9931028 DOI: 10.1021/Bi9815896  0.314
1996 Costi M, Tondi D, Rinaldi M, Barlocco D, Cignarella G, Santi D, Musiu C, Pudu I, Vacca G, La Colla P. Naphthalimido derivatives as antifolate thymidylate synthase inhibitors European Journal of Medicinal Chemistry. 31: 1011-1016. DOI: 10.1016/S0223-5234(97)86180-6  0.376
1995 Gamarro F, Yu P, Zhao J, Edman U, Greene PJ, Santi D. Trypanosoma brucei dihydrofolate reductase-thymidylate synthase: gene isolation and expression and characterization of the enzyme. Molecular and Biochemical Parasitology. 72: 11-22. PMID 8538681 DOI: 10.1016/0166-6851(95)00059-A  0.369
1994 Eckstein JW, Foster PG, Finer-Moore J, Wataya Y, Santi DV. Mechanism-based inhibition of thymidylate synthase by 5-(trifluoromethyl)-2'-deoxyuridine 5'-monophosphate. Biochemistry. 33: 15086-94. PMID 7999767 DOI: 10.1021/BI00254A018  0.326
1992 Santi DV, Edman U, Minkin S, Greene PJ. Purification and characterization of recombinant Pneumocystis carinii thymidylate synthase. Protein Expression and Purification. 2: 350-4. PMID 1821808 DOI: 10.1016/1046-5928(91)90093-X  0.308
1992 Carreras CW, Climie SC, Santi DV. Thymidylate synthase with a C-terminal deletion catalyzes partial reactions but is unable to catalyze thymidylate formation. Biochemistry. 31: 6038-44. PMID 1627546 DOI: 10.1021/BI00141A012  0.304
1991 Sirawaraporn W, Edman JC, Santi DV. Purification and properties of recombinant Pneumocystis carinii dihydrofolate reductase Protein Expression and Purification. 2: 313-316. PMID 1821803 DOI: 10.1016/1046-5928(91)90088-Z  0.329
1989 Subramaniam R, Wang Y, Mathews CK, Santi DV. On the inhibition of deoxycytidylate hydroxymethylase by 5-fluoro-2'-deoxycytidine 5'-monophosphate. Archives of Biochemistry and Biophysics. 275: 11-5. PMID 2684015 DOI: 10.1016/0003-9861(89)90343-3  0.312
1988 Santi DV, Hardy LW. Catalytic mechanism and inhibition of tRNA (uracil-5-)methyltransferase: evidence for covalent catalysis. Biochemistry. 26: 8599-606. PMID 3327525 DOI: 10.1021/BI00400A016  0.308
1977 Anderson RT, Santi DV. Phenylalanyl transfer ribonucleic acid synthetase from Escherichia coli B. Potent inhibition by analogues of N-benzyl-2-phenylethylamine. Journal of Medicinal Chemistry. 19: 1270-5. PMID 794470 DOI: 10.1021/jm00233a002  0.314
1975 Danenberg PV, Santi DV. Inhibition of phenylalanyl-tRNA synthetase by aromatic guanidines and amidines Journal of Medicinal Chemistry. 18: 528-530. PMID 1097688 DOI: 10.1002/Chin.197535131  0.327
1974 McHenry CS, Santi DV. A sulfhydryl group is not the covalent catalyst in the thymidylate synthetase reaction Biochemical and Biophysical Research Communications. 57: 204-208. PMID 4275163 DOI: 10.1016/S0006-291X(74)80377-3  0.343
1972 Santi DV, Sakai TT. Thymidylate synthetase. Model studies of inhibition by 5-trifluoromethyl-2'-deoxyuridylic acid. Biochemistry. 10: 3598-607. PMID 5146573 DOI: 10.1021/bi00795a018  0.317
1972 Santi DV, Sakai TT. Irreversible inhibition of thymidylate synthetase by 5-formyl-2'-deoxyuridylic acid. Biochemical and Biophysical Research Communications. 46: 1320-5. PMID 4622223 DOI: 10.1016/S0006-291X(72)80119-0  0.366
1971 Santi DV, Danenberg PV. Phenylalanyl transfer ribonucleic acid synthetase from escherichia coli. Analysis of the phenylalanine binding site Biochemistry. 10: 4813-4820. PMID 4334586 DOI: 10.1021/Bi00801A032  0.304
1971 Santi DV, Danenberg PV, Satterly P. Phenylalanyl transfer ribonucleic acid synthetase from escherichia coli. Reaction parameters and order of substrate addition Biochemistry. 10: 4804-4812. PMID 4334585 DOI: 10.1021/Bi00801A031  0.319
1967 Baker BR, Kawazu M, Santi DV, Schwan TJ. Irreversible Enzyme Inhibitors. LXXVII.(1,2) Inhibitors of Thymidine Phosphorylase. III.(2) Hydrophobic Bonding by 1-Substituted Uracils Containing Additional Substituents at the 5 and 6 Positions. Journal of Medicinal Chemistry. 10: 304-11. PMID 22185119 DOI: 10.1021/Jm00315A003  0.568
1967 Baker BR, Santi DV. Irreversible enzyme inhibitors. LXXIV. Inhibitors of guanine deaminase. II. Studies on bulk tolerance within enzyme-inhibitor complexes. Journal of Medicinal Chemistry. 10: 62-4. PMID 6031704 DOI: 10.1021/Jm00313A012  0.529
1967 Baker B, Santi DV. Irreversible Enzyme Inhibitors LXIX Journal of Pharmaceutical Sciences. 56: 380-384. DOI: 10.1002/Jps.2600560315  0.584
1967 Baker BR, Santi DV. Irreversible enzyme inhibitors. XCIV. inhibition of dihydrofolic reductase with derivatives of 2,6-diaminopurines Journal of Heterocyclic Chemistry. 4: 216-223. DOI: 10.1002/jhet.5570040209  0.338
1966 Baker BR, Ho BT, Coward JK, Santi DV. Analogs of tetrahydrofolic acid. 33. Hydrophobic bonding to dihydrofolic reductase V. Inhibition by some pyrimidines bridged to benzoic acid. Journal of Pharmaceutical Sciences. 55: 302-8. PMID 5960176 DOI: 10.1002/Jps.2600550308  0.621
1966 Baker BR, Schwan TJ, Santi DV. Nonclassical antimetabolites. XXV. Inhibitors of thymidine kinase. I. A new spectrophotometric assay. Inhibition by nucleoside derivatives. Journal of Medicinal Chemistry. 9: 66-72. PMID 4225176 DOI: 10.1021/Jm00319A018  0.48
1966 Baker BR, Santi DV, Coward JK, Shapiro HS, Jordaan JH. Analogs of tetrahydrofolic acid. XXXIX . selective bromoacylation of polyfunctional molecules for synthesis of active-site-directed irreversible enzyme inhibitors Journal of Heterocyclic Chemistry. 3: 425-434. DOI: 10.1002/Jhet.5570030407  0.597
1965 Baker BR, Beng-Thong Ho, Santi DV. Analogs of tetrahydrofolic acid. XXVII. Hydrophobic bonding to dihydrofolic reductase by 2-amino-4,6-disubstituted-5-alkylpyrimidines and 1-alkyl-4,6-diamino-1,2-dihydro-s-triazines. Journal of Pharmaceutical Sciences. 54: 1415-24. PMID 5883214 DOI: 10.1002/jps.2600541005  0.554
1965 Baker BR, Santi DV. Analogs of tetrahydrofolic acid XXIV. Further observations on the mode of pyrimidyl binding to dihydrofolic reductase and thymidylate synthetase by the 2-amino-5-(3-anilinopropyl)-6-methyl-4-pyrimidinol type of inhibitor. Journal of Pharmaceutical Sciences. 54: 1252-7. PMID 5881214 DOI: 10.1002/jps.2600540905  0.55
1964 BAKER BR, SANTI DV, SHAPIRO HS. ANALOGS OF TETRAHYDROFOLIC ACID. XIV. FACILE SYNTHETIC ROUTE TO THE 2-AMINO-5-(3-ANILINOPROPYL)-6-METHYL-4-PYRIMIDINOL TYPE OF FOLIC REDUCTASE AND THYMIDYLATE SYNTHETASE INHIBITOR. Journal of Pharmaceutical Sciences. 53: 1317-25. PMID 14253585 DOI: 10.1002/jps.2600531107  0.571
1964 BAKER BR, SANTI DV, ALMAULA PI, WERKEISER WC. ANALOGS OF TETRAHYDROFOLIC ACID. X. SYNTHETIC AND ENZYMIC STUDIES ON THE CONTRIBUTION OF THE P-AMINOBENZOYL-L-GLUTAMATE MOIETY OF PYRIMIDYL ANALOGS TO BINDING TO SOME FOLIC COFACTOR AREA ENZYMES. Journal of Medicinal Chemistry. 7: 24-30. PMID 14186020 DOI: 10.1021/Jm00331A007  0.531
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