| Year |
Citation |
Score |
| 2018 |
Peters TW, Nelson CS, Gerencser AA, Dumas KJ, Tavshanjian B, Chang KC, Lithgow GJ, Hughes RE. Natural Genetic Variation in Yeast Reveals That NEDD4 Is a Conserved Modifier of Mutant Polyglutamine Aggregation. G3 (Bethesda, Md.). PMID 30194090 DOI: 10.1534/G3.118.200289 |
0.695 |
|
| 2016 |
Lucanic M, Garrett T, Yu I, Calahorro F, Asadi Shahmirzadi A, Miller A, Gill MS, Hughes RE, Holden-Dye L, Lithgow GJ. Chemical activation of a food deprivation signal extends lifespan. Aging Cell. PMID 27220516 DOI: 10.1111/Acel.12492 |
0.31 |
|
| 2015 |
Peters TW, Miller AW, Tourette C, Agren H, Hubbard A, Hughes RE. Genomic Analysis of ATP Efflux in Saccharomyces cerevisiae. G3 (Bethesda, Md.). PMID 26585826 DOI: 10.1534/G3.115.023267 |
0.727 |
|
| 2014 |
Agrawal P, Reynolds J, Chew S, Lamba DA, Hughes RE. DEPTOR is a stemness factor that regulates pluripotency of embryonic stem cells. The Journal of Biological Chemistry. 289: 31818-26. PMID 25258312 DOI: 10.1074/Jbc.M114.565838 |
0.534 |
|
| 2014 |
Orr AL, Ashok D, Sarantos MR, Ng R, Shi T, Gerencser AA, Hughes RE, Brand MD. Novel inhibitors of mitochondrial sn-glycerol 3-phosphate dehydrogenase. Plos One. 9: e89938. PMID 24587137 DOI: 10.1371/Journal.Pone.0089938 |
0.732 |
|
| 2014 |
Tourette C, Li B, Bell R, O'Hare S, Kaltenbach LS, Mooney SD, Hughes RE. A large scale Huntingtin protein interaction network implicates Rho GTPase signaling pathways in Huntington disease. The Journal of Biological Chemistry. 289: 6709-26. PMID 24407293 DOI: 10.1074/Jbc.M113.523696 |
0.783 |
|
| 2013 |
Orr AL, Ashok D, Sarantos MR, Shi T, Hughes RE, Brand MD. Inhibitors of ROS production by the ubiquinone-binding site of mitochondrial complex I identified by chemical screening. Free Radical Biology & Medicine. 65: 1047-59. PMID 23994103 DOI: 10.1016/J.Freeradbiomed.2013.08.170 |
0.741 |
|
| 2012 |
Sarantos MR, Papanikolaou T, Ellerby LM, Hughes RE. Pizotifen Activates ERK and Provides Neuroprotection in vitro and in vivo in Models of Huntington's Disease. Journal of Huntington's Disease. 1: 195-210. PMID 23393546 DOI: 10.3233/Jhd-120033 |
0.741 |
|
| 2012 |
Miller JP, Yates BE, Al-Ramahi I, Berman AE, Sanhueza M, Kim E, de Haro M, DeGiacomo F, Torcassi C, Holcomb J, Gafni J, Mooney SD, Botas J, Ellerby LM, Hughes RE. A genome-scale RNA-interference screen identifies RRAS signaling as a pathologic feature of Huntington's disease. Plos Genetics. 8: e1003042. PMID 23209424 DOI: 10.1371/Journal.Pgen.1003042 |
0.617 |
|
| 2012 |
Peters TW, Rardin MJ, Czerwieniec G, Evani US, Reis-Rodrigues P, Lithgow GJ, Mooney SD, Gibson BW, Hughes RE. Tor1 regulates protein solubility in Saccharomyces cerevisiae. Molecular Biology of the Cell. 23: 4679-88. PMID 23097491 DOI: 10.1091/Mbc.E12-08-0620 |
0.787 |
|
| 2012 |
Agrawal P, Chen YT, Schilling B, Gibson BW, Hughes RE. Ubiquitin-specific peptidase 9, X-linked (USP9X) modulates activity of mammalian target of rapamycin (mTOR). The Journal of Biological Chemistry. 287: 21164-75. PMID 22544753 DOI: 10.1074/Jbc.M111.328021 |
0.674 |
|
| 2012 |
Laberge RM, Zhou L, Sarantos MR, Rodier F, Freund A, de Keizer PL, Liu S, Demaria M, Cong YS, Kapahi P, Desprez PY, Hughes RE, Campisi J. Glucocorticoids suppress selected components of the senescence-associated secretory phenotype. Aging Cell. 11: 569-78. PMID 22404905 DOI: 10.1111/J.1474-9726.2012.00818.X |
0.749 |
|
| 2012 |
Reis-Rodrigues P, Czerwieniec G, Peters TW, Evani US, Alavez S, Gaman EA, Vantipalli M, Mooney SD, Gibson BW, Lithgow GJ, Hughes RE. Proteomic analysis of age-dependent changes in protein solubility identifies genes that modulate lifespan. Aging Cell. 11: 120-7. PMID 22103665 DOI: 10.1111/J.1474-9726.2011.00765.X |
0.775 |
|
| 2010 |
Varma H, Yamamoto A, Sarantos MR, Hughes RE, Stockwell BR. Mutant huntingtin alters cell fate in response to microtubule depolymerization via the GEF-H1-RhoA-ERK pathway. The Journal of Biological Chemistry. 285: 37445-57. PMID 20858895 DOI: 10.1074/Jbc.M110.125542 |
0.769 |
|
| 2010 |
Gorbea C, Pratt G, Ustrell V, Bell R, Sahasrabudhe S, Hughes RE, Rechsteiner M. A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. The Journal of Biological Chemistry. 285: 31616-33. PMID 20682791 DOI: 10.1074/Jbc.M110.154120 |
0.393 |
|
| 2010 |
Miller JP, Holcomb J, Al-Ramahi I, de Haro M, Gafni J, Zhang N, Kim E, Sanhueza M, Torcassi C, Kwak S, Botas J, Hughes RE, Ellerby LM. Matrix metalloproteinases are modifiers of huntingtin proteolysis and toxicity in Huntington's disease. Neuron. 67: 199-212. PMID 20670829 DOI: 10.1016/J.Neuron.2010.06.021 |
0.553 |
|
| 2009 |
Bell R, Hubbard A, Chettier R, Chen D, Miller JP, Kapahi P, Tarnopolsky M, Sahasrabuhde S, Melov S, Hughes RE. A human protein interaction network shows conservation of aging processes between human and invertebrate species. Plos Genetics. 5: e1000414. PMID 19293945 DOI: 10.1371/Journal.Pgen.1000414 |
0.592 |
|
| 2008 |
Vignali M, McKinlay A, LaCount DJ, Chettier R, Bell R, Sahasrabudhe S, Hughes RE, Fields S. Interaction of an atypical Plasmodium falciparum ETRAMP with human apolipoproteins. Malaria Journal. 7: 211. PMID 18937849 DOI: 10.1186/1475-2875-7-211 |
0.527 |
|
| 2008 |
Romero E, Cha GH, Verstreken P, Ly CV, Hughes RE, Bellen HJ, Botas J. Suppression of neurodegeneration and increased neurotransmission caused by expanded full-length huntingtin accumulating in the cytoplasm. Neuron. 57: 27-40. PMID 18184562 DOI: 10.1016/J.Neuron.2007.11.025 |
0.346 |
|
| 2007 |
Kaltenbach LS, Romero E, Becklin RR, Chettier R, Bell R, Phansalkar A, Strand A, Torcassi C, Savage J, Hurlburt A, Cha GH, Ukani L, Chepanoske CL, Zhen Y, Sahasrabudhe S, ... ... Hughes RE, et al. Huntingtin interacting proteins are genetic modifiers of neurodegeneration. Plos Genetics. 3: e82. PMID 17500595 DOI: 10.1371/Journal.Pgen.0030082 |
0.448 |
|
| 2005 |
LaCount DJ, Vignali M, Chettier R, Phansalkar A, Bell R, Hesselberth JR, Schoenfeld LW, Ota I, Sahasrabudhe S, Kurschner C, Fields S, Hughes RE. A protein interaction network of the malaria parasite Plasmodium falciparum. Nature. 438: 103-7. PMID 16267556 DOI: 10.1038/Nature04104 |
0.732 |
|
| 2002 |
Hughes RE. Polyglutamine disease: acetyltransferases awry. Current Biology : Cb. 12: R141-3. PMID 11864588 DOI: 10.1016/S0960-9822(02)00709-1 |
0.361 |
|
| 2001 |
Hughes RE, Lo RS, Davis C, Strand AD, Neal CL, Olson JM, Fields S. Altered transcription in yeast expressing expanded polyglutamine Proceedings of the National Academy of Sciences of the United States of America. 98: 13201-13206. PMID 11687606 DOI: 10.1073/Pnas.191498198 |
0.574 |
|
| 2001 |
Hughes RE, Olson JM. Therapeutic opportunities in polyglutamine disease Nature Medicine. 7: 419-423. PMID 11283667 DOI: 10.1038/86486 |
0.351 |
|
| 2000 |
Uetz P, Hughes RE. Systematic and large-scale two-hybrid screens Current Opinion in Microbiology. 3: 303-308. PMID 10851163 DOI: 10.1016/S1369-5274(00)00094-1 |
0.394 |
|
| 1999 |
Hughes RE, Fields S. The PDZ domain as you like it Nature Biotechnology. 17: 132-133. PMID 10052343 DOI: 10.1038/6130 |
0.445 |
|
| 1997 |
Olshevskaya EV, Hughes RE, Hurley JB, Dizhoor AM. Calcium binding, but not a calcium-myristoyl switch, controls the ability of guanylyl cyclase-activating protein GCAP-2 to regulate photoreceptor guanylyl cyclase Journal of Biological Chemistry. 272: 14327-14333. PMID 9162068 DOI: 10.1074/Jbc.272.22.14327 |
0.339 |
|
| 1993 |
Hughes RE, Rice PA, Steitz TA, Grindley ND. Protein-protein interactions directing resolvase site-specific recombination: a structure-function analysis. The Embo Journal. 12: 1447-58. PMID 8385604 DOI: 10.1002/J.1460-2075.1993.Tb05788.X |
0.628 |
|
| 1990 |
Hughes RE, Hatfull GF, Rice P, Steitz TA, Grindley ND. Cooperativity mutants of the gamma delta resolvase identify an essential interdimer interaction. Cell. 63: 1331-8. PMID 2175679 DOI: 10.1016/0092-8674(90)90428-H |
0.713 |
|
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