Eric A. Gaucher - Publications

Affiliations: 
Georgia Institute of Technology, Atlanta, GA 
Area:
molecular evolution

55 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 DeLey Cox VE, Cole MF, Gaucher EA. Incorporation of Modified Amino Acids by Engineered Elongation Factors with Expanded Substrate Capabilities. Acs Synthetic Biology. 8: 287-296. PMID 30609889 DOI: 10.1021/acssynbio.8b00305  0.96
2018 Okafor CD, Pathak MC, Fagan CE, Bauer NC, Cole MF, Gaucher EA, Ortlund EA. Structural and Dynamics Comparison of Thermostability in Ancient, Modern, and Consensus Elongation Factor Tus. Structure (London, England : 1993). 26: 118-129.e3. PMID 29276038 DOI: 10.1016/j.str.2017.11.018  0.96
2017 Kacar B, Ge X, Sanyal S, Gaucher EA. Experimental Evolution of Escherichia coli Harboring an Ancient Translation Protein. Journal of Molecular Evolution. PMID 28233029 DOI: 10.1007/s00239-017-9781-0  0.4
2016 Randall RN, Radford CE, Roof KA, Natarajan DK, Gaucher EA. An experimental phylogeny to benchmark ancestral sequence reconstruction. Nature Communications. 7: 12847. PMID 27628687 DOI: 10.1038/ncomms12847  0.44
2015 Cox VE, Gaucher EA. Molecular Evolution Directs Protein Translation Using Unnatural Amino Acids. Current Protocols in Chemical Biology. 7: 223-8. PMID 26629613 DOI: 10.1002/9780470559277.ch150115  0.64
2014 Cox VE, Gaucher EA. Engineering proteins by reconstructing evolutionary adaptive paths Methods in Molecular Biology. 1179: 353-363. PMID 25055790 DOI: 10.1007/978-1-4939-1053-3_24  0.96
2014 Cicerchi C, Li N, Kratzer J, Garcia G, Roncal-Jimenez CA, Tanabe K, Hunter B, Rivard CJ, Sautin YY, Gaucher EA, Johnson RJ, Lanaspa MA. Uric acid-dependent inhibition of AMP kinase induces hepatic glucose production in diabetes and starvation: Evolutionary implications of the uricase loss in hominids Faseb Journal. 28: 3339-3350. PMID 24755741 DOI: 10.1096/fj.13-243634  0.96
2014 Risso VA, Gavira JA, Gaucher EA, Sanchez-Ruiz JM. Phenotypic comparisons of consensus variants versus laboratory resurrections of Precambrian proteins Proteins: Structure, Function and Bioinformatics. 82: 887-896. PMID 24710963 DOI: 10.1002/prot.24575  0.96
2014 Veleva-Rotse BO, Smart JL, Baas AF, Edmonds B, Zhao ZM, Brown A, Klug LR, Hansen K, Reilly G, Gardner AP, Subbiah K, Gaucher EA, Clevers H, Barnes AP. STRAD pseudokinases regulate axogenesis and LKB1 stability. Neural Development. 9: 5. PMID 24594058 DOI: 10.1186/1749-8104-9-5  0.96
2014 Kratzer JT, Lanaspa MA, Murphy MN, Cicerchi C, Graves CL, Tipton PA, Ortlund EA, Johnson RJ, Gaucher EA. Evolutionary history and metabolic insights of ancient mammalian uricases Proceedings of the National Academy of Sciences of the United States of America. 111: 3763-3768. PMID 24550457 DOI: 10.1073/pnas.1320393111  0.96
2014 Risso VA, Manssour-Triedo F, Delgado-Delgado A, Arco R, Barroso-delJesus A, Ingles-Prieto A, Godoy-Ruiz R, Gavira JA, Gaucher EA, Ibarra-Molero B, Sanchez-Ruiz JM. Mutational studies on resurrected ancestral proteins reveal conservation of site-specific amino acid preferences throughout evolutionary history Molecular Biology and Evolution. 32: 440-455. DOI: 10.1093/molbev/msu312  0.96
2013 Ingles-Prieto A, Ibarra-Molero B, Delgado-Delgado A, Perez-Jimenez R, Fernandez JM, Gaucher EA, Sanchez-Ruiz JM, Gavira JA. Conservation of protein structure over four billion years Structure. 21: 1690-1697. PMID 23932589 DOI: 10.1016/j.str.2013.06.020  0.96
2013 Kaçar B, Gaucher EA. Experimental evolution of protein-protein interaction networks Biochemical Journal. 453: 311-319. PMID 23849056 DOI: 10.1042/BJ20130205  0.96
2013 Laos R, Shaw R, Leal NA, Gaucher E, Benner S. Directed evolution of polymerases to accept nucleotides with nonstandard hydrogen bond patterns. Biochemistry. 52: 5288-94. PMID 23815560 DOI: 10.1021/bi400558c  0.96
2013 Petrov AS, Bernier CR, Hershkovits E, Xue Y, Waterbury CC, Hsiao C, Stepanov VG, Gaucher EA, Grover MA, Harvey SC, Hud NV, Wartell RM, Fox GE, Williams LD. Secondary structure and domain architecture of the 23S and 5S rRNAs. Nucleic Acids Research. 41: 7522-35. PMID 23771137 DOI: 10.1093/nar/gkt513  0.96
2013 Cole MF, Cox VE, Gratton KL, Gaucher EA. Reconstructing evolutionary adaptive paths for protein engineering. Methods in Molecular Biology (Clifton, N.J.). 978: 115-25. PMID 23423892 DOI: 10.1007/978-1-62703-293-3_8  0.96
2013 Risso VA, Gavira JA, Mejia-Carmona DF, Gaucher EA, Sanchez-Ruiz JM. Hyperstability and substrate promiscuity in laboratory resurrections of precambrian β-lactamases Journal of the American Chemical Society. 135: 2899-2902. PMID 23394108 DOI: 10.1021/ja311630a  0.96
2013 Cacan E, Kratzer JT, Cole MF, Gaucher EA. Interchanging functionality among homologous elongation factors using signatures of heterotachy. Journal of Molecular Evolution. 76: 4-12. PMID 23370546 DOI: 10.1007/s00239-013-9540-9  0.96
2013 Gromiha MM, Pathak MC, Saraboji K, Ortlund EA, Gaucher EA. Hydrophobic environment is a key factor for the stability of thermophilic proteins Proteins: Structure, Function and Bioinformatics. 81: 715-721. PMID 23319168 DOI: 10.1002/prot.24232  0.96
2012 Zhou Y, Asahara H, Gaucher EA, Chong S. Reconstitution of translation from Thermus thermophilus reveals a minimal set of components sufficient for protein synthesis at high temperatures and functional conservation of modern and ancient translation components Nucleic Acids Research. 40: 7932-7945. PMID 22723376 DOI: 10.1093/nar/gks568  0.96
2012 Petrov AS, Bernier CR, Hsiao C, Okafor CD, Tannenbaum E, Stern J, Gaucher E, Schneider D, Hud NV, Harvey SC, Williams LD. RNA-magnesium-protein interactions in large ribosomal subunit. The Journal of Physical Chemistry. B. 116: 8113-20. PMID 22712611 DOI: 10.1021/jp304723w  0.96
2012 Kaçar B, Gaucher E. Towards the recapitulation of ancient history in the laboratory: Combining synthetic biology with experimental evolution Artificial Life 13: Proceedings of the 13th International Conference On the Simulation and Synthesis of Living Systems, Alife 2012. 11-18.  0.96
2011 Johnson RJ, Lanaspa MA, Gaucher EA. Uric Acid: A Danger Signal From the RNA World That May Have a Role in the Epidemic of Obesity, Metabolic Syndrome, and Cardiorenal Disease: Evolutionary Considerations Seminars in Nephrology. 31: 394-399. PMID 22000645 DOI: 10.1016/j.semnephrol.2011.08.002  0.96
2011 Zhao ZM, Reynolds AB, Gaucher EA. The evolutionary history of the catenin gene family during metazoan evolution. Bmc Evolutionary Biology. 11: 198. PMID 21740572 DOI: 10.1186/1471-2148-11-198  0.4
2011 Cole MF, Gaucher EA. Utilizing natural diversity to evolve protein function: applications towards thermostability. Current Opinion in Chemical Biology. 15: 399-406. PMID 21470898 DOI: 10.1016/j.cbpa.2011.03.005  0.96
2011 Perez-Jimenez R, Inglés-Prieto A, Zhao ZM, Sanchez-Romero I, Alegre-Cebollada J, Kosuri P, Garcia-Manyes S, Kappock TJ, Tanokura M, Holmgren A, Sanchez-Ruiz JM, Gaucher EA, Fernandez JM. Single-molecule paleoenzymology probes the chemistry of resurrected enzymes. Nature Structural & Molecular Biology. 18: 592-6. PMID 21460845 DOI: 10.1038/nsmb.2020  0.96
2011 Cole MF, Gaucher EA. Exploiting models of molecular evolution to efficiently direct protein engineering. Journal of Molecular Evolution. 72: 193-203. PMID 21132281 DOI: 10.1007/s00239-010-9415-2  0.96
2011 Zhao ZM, Reynolds AB, Gaucher EA. The evolutionary history of the catenin gene family during metazoan evolution Bmc Evolutionary Biology. 11. DOI: 10.1186/1471-2148-11-198  0.96
2010 Carnahan RH, Rokas A, Gaucher EA, Reynolds AB. The molecular evolution of the p120-catenin subfamily and its functional associations. Plos One. 5: e15747. PMID 21209830 DOI: 10.1371/journal.pone.0015747  0.96
2010 Gaucher EA, Kratzer JT, Randall RN. Deep phylogeny--how a tree can help characterize early life on Earth. Cold Spring Harbor Perspectives in Biology. 2: a002238. PMID 20182607 DOI: 10.1101/cshperspect.a002238  0.96
2010 Chen F, Gaucher EA, Leal NA, Hutter D, Havemann SA, Govindarajan S, Ortlund EA, Benner SA. Reconstructed evolutionary adaptive paths give polymerases accepting reversible terminators for sequencing and SNP detection. Proceedings of the National Academy of Sciences of the United States of America. 107: 1948-53. PMID 20080675 DOI: 10.1073/pnas.0908463107  0.96
2009 Perez-Jimenez R, Li J, Kosuri P, Sanchez-Romero I, Wiita AP, Rodriguez-Larrea D, Chueca A, Holmgren A, Miranda-Vizuete A, Becker K, Cho SH, Beckwith J, Gelhaye E, Jacquot JP, Gaucher EA, ... Gaucher E, et al. Diversity of chemical mechanisms in thioredoxin catalysis revealed by single-molecule force spectroscopy. Nature Structural & Molecular Biology. 16: 890-6. PMID 19597482 DOI: 10.1038/nsmb.1627  0.96
2008 Johnson RJ, Gaucher EA, Sautin YY, Henderson GN, Angerhofer AJ, Benner SA. The planetary biology of ascorbate and uric acid and their relationship with the epidemic of obesity and cardiovascular disease. Medical Hypotheses. 71: 22-31. PMID 18331782 DOI: 10.1016/j.mehy.2008.01.017  0.96
2008 Gaucher EA, Govindarajan S, Ganesh OK. Palaeotemperature trend for Precambrian life inferred from resurrected proteins. Nature. 451: 704-7. PMID 18256669 DOI: 10.1038/nature06510  0.96
2008 Brooks DJ, Gaucher EA. A thermophilic last universal ancestor inferred from its estimated amino acid composition Ancestral Sequence Reconstruction. DOI: 10.1093/acprof:oso/9780199299188.003.0017  0.96
2008 Gaucher EA. Experimental resurrection of ancient biomolecules: gene synthesis, heterologous protein expression, and functional assays Ancestral Sequence Reconstruction. DOI: 10.1093/acprof:oso/9780199299188.003.0014  0.96
2008 Danchin EGJ, Gaucher EA, Pontarotti P. Computational reconstruction of ancestral genomic regions from evolutionarily conserved gene clusters Ancestral Sequence Reconstruction. DOI: 10.1093/acprof:oso/9780199299188.003.0013  0.96
2008 Gaucher EA. Ancestral sequence reconstruction as a tool to understand natural history and guide synthetic biology: realizing and extending the vision of Zuckerkandl and Pauling Ancestral Sequence Reconstruction. DOI: 10.1093/acprof:oso/9780199299188.003.0002  0.96
2007 Benner SA, Sassi SO, Gaucher EA. Molecular paleoscience: systems biology from the past. Advances in Enzymology and Related Areas of Molecular Biology. 75: 1-132, xi. PMID 17124866 DOI: 10.1002/9780471224464.ch1  0.96
2006 Li T, Chamberlin SG, Caraco MD, Liberles DA, Gaucher EA, Benner SA. Analysis of transitions at two-fold redundant sites in mammalian genomes. Transition redundant approach-to-equilibrium (TREx) distance metrics. Bmc Evolutionary Biology. 6: 25. PMID 16545144 DOI: 10.1186/1471-2148-6-25  0.96
2006 Gaucher EA, De Kee DW, Benner SA. Application of DETECTER, an evolutionary genomic tool to analyze genetic variation, to the cystic fibrosis gene family. Bmc Genomics. 7: 44. PMID 16522197 DOI: 10.1186/1471-2164-7-44  0.96
2006 Phillips SE, Vincent P, Rizzieri KE, Schaaf G, Bankaitis VA, Gaucher EA. The diverse biological functions of phosphatidylinositol transfer proteins in eukaryotes. Critical Reviews in Biochemistry and Molecular Biology. 41: 21-49. PMID 16455519 DOI: 10.1080/10409230500519573  0.96
2005 Gaucher EA, Miyamoto MM. A call for likelihood phylogenetics even when the process of sequence evolution is heterogeneous Molecular Phylogenetics and Evolution. 37: 928-931. PMID 16291095 DOI: 10.1016/j.ympev.2005.03.027  0.96
2005 Thomson JM, Gaucher EA, Burgan MF, De Kee DW, Li T, Aris JP, Benner SA. Resurrecting ancestral alcohol dehydrogenases from yeast. Nature Genetics. 37: 630-5. PMID 15864308 DOI: 10.1038/ng1553  0.96
2004 Gaucher EA, Graddy LG, Li T, Simmen RC, Simmen FA, Schreiber DR, Liberles DA, Janis CM, Benner SA. The planetary biology of cytochrome P450 aromatases. Bmc Biology. 2: 19. PMID 15315709 DOI: 10.1186/1741-7007-2-19  0.96
2004 West CM, Van Der Wel H, Sassi S, Gaucher EA. Cytoplasmic glycosylation of protein-hydroxyproline and its relationship to other glycosylation pathways Biochimica Et Biophysica Acta - General Subjects. 1673: 29-44. PMID 15238247 DOI: 10.1016/j.bbagen.2004.04.007  0.96
2003 Gaucher EA, Thomson JM, Burgan MF, Benner SA. Inferring the palaeoenvironment of ancient bacteria on the basis of resurrected proteins. Nature. 425: 285-8. PMID 13679914 DOI: 10.1038/nature01977  0.96
2003 Gaucher EA, Miyamoto MM, Benner SA. Evolutionary, structural and biochemical evidence for a new interaction site of the leptin obesity protein. Genetics. 163: 1549-53. PMID 12702697  0.96
2002 Gaucher EA, Gu X, Miyamoto MM, Benner SA. Predicting functional divergence in protein evolution by site-specific rate shifts. Trends in Biochemical Sciences. 27: 315-21. PMID 12069792 DOI: 10.1016/S0968-0004(02)02094-7  0.96
2002 Benner SA, Caraco MD, Thomson JM, Gaucher EA. Planetary biology--paleontological, geological, and molecular histories of life. Science (New York, N.Y.). 296: 864-8. PMID 11988562 DOI: 10.1126/science.1069863  0.96
2002 Gaucher EA, Das UK, Miyamoto MM, Benner SA. The crystal structure of eEF1A refines the functional predictions of an evolutionary analysis of rate changes among elongation factors. Molecular Biology and Evolution. 19: 569-73. PMID 11919299  0.96
2002 West CM, Van Der Wel H, Gaucher EA. Complex glycosylation of Skp1 in Dictyostelium: Implications for the modification of other eukaryotic cytoplasmic and nuclear proteins Glycobiology. 12: 17R-27R. PMID 11886837  0.96
2001 Benner SA, Gaucher EA. Evolution, language and analogy in functional genomics. Trends in Genetics : Tig. 17: 414-8. PMID 11418223 DOI: 10.1016/S0168-9525(01)02320-4  0.96
2001 Gaucher EA, Miyamoto MM, Benner SA. Function-structure analysis of proteins using covarion-based evolutionary approaches: Elongation factors. Proceedings of the National Academy of Sciences of the United States of America. 98: 548-52. PMID 11209054 DOI: 10.1073/pnas.98.2.548  0.96
1998 Laten HM, Majumdar A, Gaucher EA. SIRE-1, a copia/Ty1 -like retroelement from soybean, encodes a retroviral envelope-like protein Proceedings of the National Academy of Sciences of the United States of America. 95: 6897-6902. PMID 9618510  0.96
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