☰

cached image

Theodore R. Holman - Publications

Affiliations: 
Chemistry & Biochemistry University of California, Santa Cruz, Santa Cruz, CA, United States 
Area:
lipoxygenase
Website:
http://www.chemistry.ucsc.edu/faculty/singleton.php?&singleton=true&cruz_id=holman
Tree Info Similar researchers PubMed Report error

36 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Deschamps JD, Ogunsola AF, Jameson JB, Yasgar A, Flitter BA, Freedman CJ, Melvin JA, Maloney DJ, Jadhav A, Simeonov A, Bomberger JM, Holman TR, Nguyen JV. Biochemical/Cellular Characterization and Inhibitor discovery of Pseudomonas aeruginosa 15-Lipoxygenase. Biochemistry. PMID 27226387 DOI: 10.1021/Acs.Biochem.6B00338  0.593
2015 Jameson JB, Kenyon V, Holman TR. A high-throughput mass spectrometric assay for discovery of human lipoxygenase inhibitors and allosteric effectors. Analytical Biochemistry. 476: 45-50. PMID 25712042 DOI: 10.1016/J.Ab.2015.02.011  0.609
2015 Jameson JB, Kenyon V, Holman TR. A high-throughput mass spectrometric assay for discovery of human lipoxygenase inhibitors and allosteric effectors Analytical Biochemistry. 476: 45-50. DOI: 10.1016/j.ab.2015.02.011  0.565
2014 Jameson JB, Kantz A, Schultz L, Kalyanaraman C, Jacobson MP, Maloney DJ, Jadhav A, Simeonov A, Holman TR. A high throughput screen identifies potent and selective inhibitors to human epithelial 15-lipoxygenase-2. Plos One. 9: e104094. PMID 25111178 DOI: 10.1371/Journal.Pone.0104094  0.62
2014 Smyrniotis CJ, Barbour SR, Xia Z, Hixon MS, Holman TR. ATP allosterically activates the human 5-lipoxygenase molecular mechanism of arachidonic acid and 5(S)-hydroperoxy-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid. Biochemistry. 53: 4407-19. PMID 24893149 DOI: 10.1021/Bi401621D  0.365
2014 Luci DK, Jameson JB, Yasgar A, Diaz G, Joshi N, Kantz A, Markham K, Perry S, Kuhn N, Yeung J, Kerns EH, Schultz L, Holinstat M, Nadler JL, Taylor-Fishwick DA, ... ... Holman TR, et al. Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase. Journal of Medicinal Chemistry. 57: 495-506. PMID 24393039 DOI: 10.1021/Jm4016476  0.593
2013 Joshi N, Hoobler EK, Perry S, Diaz G, Fox B, Holman TR. Kinetic and structural investigations into the allosteric and pH effect on the substrate specificity of human epithelial 15-lipoxygenase-2. Biochemistry. 52: 8026-35. PMID 24171444 DOI: 10.1021/Bi4010649  0.371
2011 Kenyon V, Rai G, Jadhav A, Schultz L, Armstrong M, Jameson JB, Perry S, Joshi N, Bougie JM, Leister W, Taylor-Fishwick DA, Nadler JL, Holinstat M, Simeonov A, Maloney DJ, ... Holman TR, et al. Discovery of potent and selective inhibitors of human platelet-type 12-lipoxygenase Journal of Medicinal Chemistry. 54: 5485-5497. PMID 21739938 DOI: 10.1021/Jm2005089  0.602
2010 Rai G, Kenyon V, Jadhav A, Schultz L, Armstrong M, Jameson JB, Hoobler E, Leister W, Simeonov A, Holman TR, Maloney DJ. Discovery of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1 Journal of Medicinal Chemistry. 53: 7392-7404. PMID 20866075 DOI: 10.1021/Jm1008852  0.631
2009 Wecksler AT, Garcia NK, Holman TR. Substrate specificity effects of lipoxygenase products and inhibitors on soybean lipoxygenase-1 Bioorganic and Medicinal Chemistry. 17: 6534-6539. PMID 19716306 DOI: 10.1016/J.Bmc.2009.08.005  0.677
2009 Wecksler AT, Kenyon V, Garcia NK, Deschamps JD, Van Der Donk WA, Holman TR. Kinetic and structural investigations of the allosteric site in human epithelial 15-lipoxygenase-2 Biochemistry. 48: 8721-8730. PMID 19645454 DOI: 10.1021/Bi9009242  0.683
2009 Wecksler AT, Jacquot C, Van Der Donk WA, Holman TR. Mechanistic investigations of human reticulocyte 15- and platelet 12-lipoxygenases with arachidonic acid Biochemistry. 48: 6259-6267. PMID 19469483 DOI: 10.1021/Bi802332J  0.682
2008 Jacquot C, McGinley CM, Plata E, Holman TR, van der Donk WA. Synthesis of 11-thialinoleic acid and 14-thialinoleic acid, inhibitors of soybean and human lipoxygenases. Organic & Biomolecular Chemistry. 6: 4242-52. PMID 18972057 DOI: 10.1039/B808003H  0.307
2008 Sarangi R, Hocking RK, Neidig ML, Benfatto M, Holman TR, Solomon EI, Hodgson KO, Hedman B. Geometric structure determination of N694C lipoxygenase: a comparative near-edge X-ray absorption spectroscopy and extended X-ray absorption fine structure study. Inorganic Chemistry. 47: 11543-50. PMID 18656914 DOI: 10.1021/Ic800580F  0.303
2008 Wecksler AT, Kenyon V, Deschamps JD, Holman TR. Substrate specificity changes for human reticulocyte and epithelial 15-lipoxygenases reveal allosteric product regulation Biochemistry. 47: 7364-7375. PMID 18570379 DOI: 10.1021/Bi800550N  0.692
2008 Jacquot C, Wecksler AT, McGinley CM, Segraves EN, Holman TR, van der Donk WA. Isotope sensitive branching and kinetic isotope effects in the reaction of deuterated arachidonic acids with human 12- and 15-lipoxygenases. Biochemistry. 47: 7295-303. PMID 18547056 DOI: 10.1021/Bi800308Q  0.677
2007 Thompson AM, Reddi AR, Shi X, Goldbeck RA, Moënne-Loccoz P, Gibney BR, Holman TR. Measurement of the heme affinity for yeast dap1p, and its importance in cellular function. Biochemistry. 46: 14629-37. PMID 18031064 DOI: 10.1021/Bi7013739  0.454
2007 Neidig ML, Wecksler AT, Schenk G, Holman TR, Solomon EI. Kinetic and spectroscopic studies of N694C lipoxygenase: A probe of the substrate activation mechanism of a nonheme ferric enzyme Journal of the American Chemical Society. 129: 7531-7537. PMID 17523638 DOI: 10.1021/Ja068503D  0.7
2006 Segraves EN, Chruszcz M, Neidig ML, Ruddat V, Zhou J, Wecksler AT, Minor W, Solomon EI, Holman TR. Kinetic, spectroscopic, and structural investigations of the soybean lipoxygenase-1 first-coordination sphere mutant, Asn694Gly Biochemistry. 45: 10233-10242. PMID 16922498 DOI: 10.1021/Bi060577E  0.69
2006 Kenyon V, Chorny I, Carvajal WJ, Holman TR, Jacobson MP. Novel human lipoxygenase inhibitors discovered using virtual screening with homology models Journal of Medicinal Chemistry. 49: 1356-1363. PMID 16480270 DOI: 10.1021/Jm050639J  0.338
2005 Ghosh K, Thompson AM, Goldbeck RA, Shi X, Whitman S, Oh E, Zhiwu Z, Vulpe C, Holman TR. Spectroscopic and biochemical characterization of heme binding to yeast Dap1p and mouse PGRMC1p Biochemistry. 44: 16729-16736. PMID 16342963 DOI: 10.1021/Bi0511585  0.632
2004 Ruddat VC, Mogul R, Chorny I, Chen C, Perrin N, Whitman S, Kenyon V, Jacobson MP, Bernasconi CF, Holman TR. Tryptophan 500 and arginine 707 define product and substrate active site binding in soybean lipoxygenase-1 Biochemistry. 43: 13063-13071. PMID 15476400 DOI: 10.1021/Bi0489098  0.365
2004 Segraves EN, Shah RR, Segraves NL, Johnson TA, Whitman S, Sui JK, Kenyon VA, Cichewicz RH, Crews P, Holman TR. Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase. Journal of Medicinal Chemistry. 47: 4060-5. PMID 15267244 DOI: 10.1021/Jm049872S  0.339
2004 Ghosh K, Eroy-Reveles AA, Avila B, Holman TR, Olmstead MM, Mascharak PK. Reactions of NO with Mn(II) and Mn(III) Centers Coordinated to Carboxamido Nitrogen: Synthesis of a Manganese Nitrosyl with Photolabile NO Inorganic Chemistry. 43: 2988-2997. PMID 15106989 DOI: 10.1021/Ic030331N  0.712
2003 Schenk G, Neidig ML, Zhou J, Holman TR, Solomon EI. Spectroscopic characterization of soybean lipoxygenase-1 mutants: The role of second coordination sphere residues in the regulation of enzyme activity Biochemistry. 42: 7294-7302. PMID 12809485 DOI: 10.1021/Bi027380G  0.367
2003 Segraves EN, Holman TR. Kinetic investigations of the rate-limiting step in human 12- and 15-lipoxygenase Biochemistry. 42: 5236-5243. PMID 12731864 DOI: 10.1021/Bi0273462  0.364
2003 Ruddat VC, Whitman S, Holman TR, Bernasconi CF. Stopped-flow kinetic investigations of the activation of soybean lipoxygenase-1 and the influence of inhibitors on the allosteric site Biochemistry. 42: 4172-4178. PMID 12680771 DOI: 10.1021/Bi020698O  0.403
2003 Schenk G, Neidig ML, Zhou J, Holman TR, Solomon EI. Spectroscopic characterization of soybean lipoxygenase-1: The role of second coordination sphere residues in the regulation of enzyme activity Journal of Inorganic Biochemistry. 96: 225. DOI: 10.1016/S0162-0134(03)80762-6  0.305
2001 Mogul R, Holman TR. Inhibition studies of soybean and human 15-lipoxygenases with long-chain alkenyl sulfate substrates Biochemistry. 40: 4391-4397. PMID 11284695 DOI: 10.1021/Bi002581A  0.409
2000 Mogul R, Johansen E, Holman TR. Oleyl sulfate reveals allosteric inhibition of soybean lipoxygenase-1 and human 15-lipoxygenase Biochemistry. 39: 4801-4807. PMID 10769137 DOI: 10.1021/Bi992805T  0.409
1993 Wang Z, Holman TR, Que L. Two-dimensional1H NMR studies of paramagnetic bimetallic mixed-metal complexes Magnetic Resonance in Chemistry. 31: S78-S84. DOI: 10.1002/Mrc.1260311316  0.324
1991 Juarez-Garcia C, Hendrich MP, Holman TR, Que L, Munck E. Combined Moessbauer and EPR studies of the S = 3 state of an exchange-coupled iron(III)-copper(II) complex: test for quantitative EPR analysis of integer spin systems Journal of the American Chemical Society. 113: 518-525. DOI: 10.1021/Ja00002A020  0.549
1990 Borovik AS, Hendrich MP, Holman TR, Münck E, Papaefthymiou V, Que L. Models for diferrous forms of iron-oxo proteins. Structure and properties of [Fe2BPMP(O2CR)2]BPh4 complexes Journal of the American Chemical Society. 112: 6031-6038. DOI: 10.1021/Ja00172A019  0.537
1990 Holman TR, Andersen KA, Anderson OP, Hendrich MP, Juarez-Garcia C, Münck E, Que L. Correlations between magnetism and structure in dinuclear CuIIFeIII complexes with integer spin EPR signals Angewandte Chemie (International Edition in English). 29: 921-923. DOI: 10.1002/Anie.199009211  0.516
1990 Holman TR, Andersen KA, Anderson OP, Hendrich MP, Juarez-Garcia C, Münck E, Que L. Korrelationen zwischen Magnetismus und Struktur in zweikernigen CuIIFeIII-Komplexen mit EPR-Signalen von ganzzahligem Spin Angewandte Chemie. 102: 933-935. DOI: 10.1002/Ange.19901020821  0.496
1989 Holman T, Que L, Hendrich M, Juarez C, Münck E, Anderson K, Anderson O. Integer spin EPR signals from a model for the Fe(III)Cu(II) center in cytochrome oxidase Journal of Inorganic Biochemistry. 36: 318. DOI: 10.1016/0162-0134(89)84500-3  0.53
Show low-probability matches.