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R. Scott Lokey - Publications

Affiliations: 
Chemistry & Biochemistry University of California, Santa Cruz, Santa Cruz, CA, United States 
Area:
drug discovery
Website:
http://www.chemistry.ucsc.edu/faculty/singleton.php?&singleton=true&cruz_id=slokey
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29 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Faris JH, Adaligil E, Popovych N, Ono S, Takahashi M, Nguyen H, Plise E, Taechalertpaisarn J, Lee HW, Koehler MFT, Cunningham CN, Lokey RS. Membrane Permeability in a Large Macrocyclic Peptide Driven by a Saddle-Shaped Conformation. Journal of the American Chemical Society. PMID 38330910 DOI: 10.1021/jacs.3c10949  0.398
2023 Zhang P, Koch G, Zhang Y, Yang K, Lokey RS. DNA-Compatible Conditions for the Formation of -Methyl Peptide Bonds. Acs Omega. 8: 23477-23483. PMID 37426286 DOI: 10.1021/acsomega.3c00576  0.74
2022 van Hoorebeke C, Yang K, Mussetter SJ, Koch G, Rutz N, Lokey RS, Crews P, Holman TR. Reevaluation of a Bicyclic Pyrazoline as a Selective 15-Lipoxygenase V-Type Activator Possessing Fatty Acid Specificity. Acs Omega. 7: 43169-43179. PMID 36467910 DOI: 10.1021/acsomega.2c05877  0.689
2022 Taechalertpaisarn J, Ono S, Okada O, Johnstone TC, Lokey RS. A New Amino Acid for Improving Permeability and Solubility in Macrocyclic Peptides through Side Chain-to-Backbone Hydrogen Bonding. Journal of Medicinal Chemistry. PMID 35275623 DOI: 10.1021/acs.jmedchem.2c00010  0.351
2021 Klein VG, Bray WM, Wang HY, Edmondson Q, Schwochert J, Ono S, Naylor MR, Turmon AC, Faris JH, Okada O, Taunton J, Lokey RS. Identifying the Cellular Target of Cordyheptapeptide A and Synthetic Derivatives. Acs Chemical Biology. PMID 34251165 DOI: 10.1021/acschembio.1c00094  0.595
2020 Kelly CN, Townsend CE, Jain AN, Naylor MR, Pye CR, Schwochert J, Lokey RS. Geometrically Diverse Lariat Peptide Scaffolds Reveal an Untapped Chemical Space of High Membrane Permeability. Journal of the American Chemical Society. PMID 33381960 DOI: 10.1021/jacs.0c06115  0.358
2020 Furukawa A, Schwochert J, Pye CR, Asano D, Edmondson QD, Turmon A, Klein V, Ono S, Okada O, Lokey RS. Drug-like properties in macrocycles above MW 1000: Backbone rigidity vs. side-chain lipophilicity. Angewandte Chemie (International Ed. in English). PMID 32789999 DOI: 10.1002/anie.202004550  0.303
2018 Nguyen QNN, Schwochert J, Tantillo DJ, Lokey RS. Using H and C NMR chemical shifts to determine cyclic peptide conformations: a combined molecular dynamics and quantum mechanics approach. Physical Chemistry Chemical Physics : Pccp. PMID 29744489 DOI: 10.1039/C8Cp01616J  0.315
2018 Townsend C, Furukawa A, Schwochert J, Pye CR, Edmondson Q, Lokey RS. CycLS: Accurate, whole-library sequencing of cyclic peptides using tandem mass spectrometry. Bioorganic & Medicinal Chemistry. PMID 29459147 DOI: 10.1016/j.bmc.2018.01.027  0.405
2017 Boehm M, Beaumont K, Jones RM, Kalgutkar AS, Zhang L, Atkinson K, Bai G, Brown JA, Eng H, Goetz GH, Holder BR, Khunte B, Lazzaro S, Limberakis C, Ryu S, ... ... Lokey RS, et al. Discovery of potent and orally bioavailable macrocyclic peptide-peptoid hybrid CXCR7 modulators. Journal of Medicinal Chemistry. PMID 29045152 DOI: 10.1021/Acs.Jmedchem.7B01028  0.642
2017 Naylor MR, Bockus AT, Blanco MJ, Lokey RS. Cyclic peptide natural products chart the frontier of oral bioavailability in the pursuit of undruggable targets. Current Opinion in Chemical Biology. 38: 141-147. PMID 28570865 DOI: 10.1016/j.cbpa.2017.04.012  0.352
2016 Furukawa A, Townsend CE, Schwochert JA, Pye CR, Bednarek MA, Lokey RS. Passive membrane permeability in cyclic peptomer scaffolds is robust to extensive variation in side chain functionality and backbone geometry. Journal of Medicinal Chemistry. PMID 27690434 DOI: 10.1021/acs.jmedchem.6b01246  0.305
2016 Schwochert J, Lao Y, Pye CR, Naylor MR, Desai PV, Gonzalez Valcarcel IC, Barrett JA, Sawada G, Blanco MJ, Lokey RS. Stereochemistry Balances Cell Permeability and Solubility in the Naturally Derived Phepropeptin Cyclic Peptides. Acs Medicinal Chemistry Letters. 7: 757-61. PMID 27563399 DOI: 10.1021/acsmedchemlett.6b00100  0.301
2015 Ahlbach CL, Lexa KW, Bockus AT, Chen V, Crews P, Jacobson MP, Lokey RS. Beyond cyclosporine A: conformation-dependent passive membrane permeabilities of cyclic peptide natural products. Future Medicinal Chemistry. 1-10. PMID 26067057 DOI: 10.4155/Fmc.15.78  0.315
2015 Schwochert J, Turner R, Thang M, Berkeley RF, Ponkey AR, Rodriguez KM, Leung SS, Khunte B, Goetz G, Limberakis C, Kalgutkar AS, Eng H, Shapiro MJ, Mathiowetz AM, Price DA, ... ... Lokey RS, et al. Peptide to Peptoid Substitutions Increase Cell Permeability in Cyclic Hexapeptides. Organic Letters. 17: 2928-31. PMID 26046483 DOI: 10.1021/Acs.Orglett.5B01162  0.6
2015 Bockus AT, Lexa KW, Pye CR, Kalgutkar AS, Gardner JW, Hund KC, Hewitt WM, Schwochert JA, Glassey E, Price DA, Mathiowetz AM, Liras S, Jacobson MP, Lokey RS. Probing the Physicochemical Boundaries of Cell Permeability and Oral Bioavailability in Lipophilic Macrocycles Inspired by Natural Products. Journal of Medicinal Chemistry. 58: 4581-9. PMID 25950816 DOI: 10.1021/Acs.Jmedchem.5B00128  0.355
2015 Hewitt WM, Leung SS, Pye CR, Ponkey AR, Bednarek M, Jacobson MP, Lokey RS. Cell-permeable cyclic peptides from synthetic libraries inspired by natural products. Journal of the American Chemical Society. 137: 715-21. PMID 25517352 DOI: 10.1021/Ja508766B  0.357
2014 Schwochert J, Pye C, Ahlbach C, Abdollahian Y, Farley K, Khunte B, Limberakis C, Kalgutkar AS, Eng H, Shapiro MJ, Mathiowetz AM, Price DA, Liras S, Lokey RS. Revisiting N-to-O acyl shift for synthesis of natural product-like cyclic depsipeptides. Organic Letters. 16: 6088-91. PMID 25412436 DOI: 10.1021/ol503170b  0.351
2013 Turner RA, Hauksson NE, Gipe JH, Lokey RS. Selective, on-resin N-methylation of peptide N-trifluoroacetamides Organic Letters. 15: 5012-5015. PMID 24063667 DOI: 10.1021/ol402341u  0.608
2013 Bockus AT, McEwen CM, Lokey RS. Form and function in cyclic peptide natural products: a pharmacokinetic perspective. Current Topics in Medicinal Chemistry. 13: 821-36. PMID 23578026  0.372
2012 Rand AC, Leung SS, Eng H, Rotter CJ, Sharma R, Kalgutkar AS, Zhang Y, Varma MV, Farley KA, Khunte B, Limberakis C, Price DA, Liras S, Mathiowetz AM, Jacobson MP, ... Lokey RS, et al. Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance(). Medchemcomm. 3: 1282-1289. PMID 23133740 DOI: 10.1039/C2Md20203D  0.342
2011 White TR, Renzelman CM, Rand AC, Rezai T, McEwen CM, Gelev VM, Turner RA, Linington RG, Leung SS, Kalgutkar AS, Bauman JN, Zhang Y, Liras S, Price DA, Mathiowetz AM, ... ... Lokey RS, et al. On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds. Nature Chemical Biology. 7: 810-7. PMID 21946276 DOI: 10.1038/Nchembio.664  0.596
2010 Turner RA, Weber RJ, Lokey RS. Direct conversion of resin-bound peptides to C-terminal esters Organic Letters. 12: 1852-1855. PMID 20329782 DOI: 10.1021/ol100471k  0.596
2007 Turner RA, Oliver AG, Lokey RS. Click chemistry as a macrocyclization tool in the solid-phase synthesis of small cyclic peptides. Organic Letters. 9: 5011-4. PMID 17956112 DOI: 10.1021/ol702228u  0.599
2005 Perlman ZE, Bock JE, Peterson JR, Lokey RS. Geometric diversity through permutation of backbone configuration in cyclic peptide libraries Bioorganic and Medicinal Chemistry Letters. 15: 5329-5334. PMID 16213707 DOI: 10.1016/J.Bmcl.2005.07.089  0.76
2001 Peterson JR, Lokey RS, Mitchison TJ, Kirschner MW. A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions. Proceedings of the National Academy of Sciences of the United States of America. 98: 10624-9. PMID 11553809 DOI: 10.1073/Pnas.201393198  0.6
2001 Guelev VM, Cubberley MS, Murr MM, Lokey RS, Iverson BL. Design, synthesis, and characterization of polyintercalating ligands. Methods in Enzymology. 340: 556-70. PMID 11494870 DOI: 10.1016/S0076-6879(01)40442-3  0.63
2000 Guelev VM, Harting MT, Lokey RS, Iverson BL. Altered sequence specificity identified from a library of DNA-binding small molecules. Chemistry & Biology. 7: 1-8. PMID 10662682 DOI: 10.1016/S1074-5521(00)00007-X  0.766
1997 Lokey RS, Kwok Y, Guelev V, Pursell CJ, Hurley LH, Iverson BL. A new class of polyintercalating molecules Journal of the American Chemical Society. 119: 7202-7210. DOI: 10.1021/Ja9706108  0.767
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