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Xingyu Lu, Ph.D. - Publications

Affiliations: 
2017-2019 Pharmaceutical Sciences Merck & Co., Inc 
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41 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Li M, Falk BT, Lu X, Schroder R, Mccoy M, Xu W, Yin DH, Gindy ME, D'Addio SM, Su Y. Molecular Mechanism of Antimicrobial Excipient-Induced Aggregation in Parenteral Formulations of Peptide Therapeutics. Molecular Pharmaceutics. PMID 35917158 DOI: 10.1021/acs.molpharmaceut.2c00449  0.612
2021 Lu X, Li M, Arce FA, Ling J, Setiawan N, Wang Y, Shi X, Campbell HR, Nethercott MJ, Xu W, Munson EJ, Marsac PJ, Su Y. Mechanistic Investigation of Drug Supersaturation in the Presence of Polysorbates as Solubilizing Additives by Solution Nuclear Magnetic Resonance Spectroscopy. Molecular Pharmaceutics. PMID 34761934 DOI: 10.1021/acs.molpharmaceut.1c00477  0.641
2020 Li M, Koranne S, Fang R, Lu X, Williams DM, Munson EJ, Bhambhani A, Su Y. Probing Microenvironmental Acidity in Lyophilized Protein and Vaccine Formulations Using Solid-state NMR Spectroscopy. Journal of Pharmaceutical Sciences. PMID 33249049 DOI: 10.1016/j.xphs.2020.11.017  0.593
2020 Arce FA, Setiawan N, Campbell HR, Lu X, Nethercott MJ, Bummer P, Su Y, Marsac PJ. Towards Developing Discriminating Dissolution Methods for Formulations Containing Nano-Particulates in Solution; The Impact of Particle Drift and Drug Activity in Solution. Molecular Pharmaceutics. PMID 32965123 DOI: 10.1021/acs.molpharmaceut.0c00599  0.497
2020 Li M, Lu X, Xu W, Troup GM, McNevin MJ, Nie H, Su Y. Quantifying Pharmaceutical Formulations from Proton Detected Solid-State NMR under Ultrafast Magic Angle Spinning. Journal of Pharmaceutical Sciences. PMID 32679211 DOI: 10.1016/J.Xphs.2020.06.026  0.694
2020 Lu X, Tsutsumi Y, Huang C, Xu W, Byrn SR, Templeton AC, Buevich AV, Amoureux JP, Su Y. Molecular packing of pharmaceuticals analyzed with paramagnetic relaxation enhancement and ultrafast magic angle pinning NMR. Physical Chemistry Chemical Physics : Pccp. PMID 32495810 DOI: 10.1039/D0Cp02049D  0.628
2020 Lu X, Li M, Huang C, Lowinger MB, Xu W, Yu L, Byrn SR, Templeton AC, Su Y. Atomic-level Drug Substance and Polymer Interaction in Posaconazole Amorphous Solid Dispersion from Solid-State NMR. Molecular Pharmaceutics. PMID 32401529 DOI: 10.1021/Acs.Molpharmaceut.0C00268  0.676
2020 Li M, Meng F, Tsutsumi Y, Amoureux JP, Xu W, Lu X, Zhang F, Su Y. Understanding Molecular Interactions in Rafoxanide-Povidone Amorphous Solid Dispersions from Ultrafast Magic Angle Spinning NMR. Molecular Pharmaceutics. PMID 32392076 DOI: 10.1021/Acs.Molpharmaceut.0C00317  0.7
2020 Lu X, Huang C, Li M, Skomski D, Xu W, Yu L, Byrn SR, Templeton AC, Su Y. Molecular Mechanism of Crystalline-to-Amorphous Conversion of Pharmaceutical Solids from F Magic Angle Spinning NMR. The Journal of Physical Chemistry. B. PMID 32378905 DOI: 10.1021/Acs.Jpcb.0C02131  0.671
2020 Liu X, Lu X, Su Y, Kun E, Zhang F. Clay-Polymer Nanocomposites Prepared by Reactive Melt Extrusion for Sustained Drug Release. Pharmaceutics. 12. PMID 31936176 DOI: 10.3390/Pharmaceutics12010051  0.548
2019 Chen Q, Xu SP, Lu X, Boeri MV, Pepelyayeva Y, Diaz EL, Soni SD, Allaire M, Forstner MB, Bahnson BJ, Rozovsky S. Se-NMR Probes the Protein Environment of Selenomethionine. The Journal of Physical Chemistry. B. PMID 31846581 DOI: 10.1021/Acs.Jpcb.9B07466  0.423
2019 Lu X, Huang C, Lowinger MB, Yang F, Xu W, Brown CD, Hesk D, Koynov A, Schenck L, Su Y. Molecular Interactions in Posaconazole Amorphous Solid Dispersions from Two-Dimensional Solid-State NMR Spectroscopy. Molecular Pharmaceutics. PMID 31021639 DOI: 10.1021/Acs.Molpharmaceut.9B00174  0.632
2019 Lu X, Skomski D, Thompson KC, McNevin MJ, Xu W, Su Y. Three-Dimensional NMR Spectroscopy of Fluorinated Pharmaceutical Solids under Ultrafast Magic Angle Spinning. Analytical Chemistry. PMID 30990668 DOI: 10.1021/Acs.Analchem.9B00884  0.617
2019 Moon C, Watts AB, Lu X, Su Y, Williams RO. Enhanced Aerosolization of High Potency Nanoaggregates of Voriconazole by Dry Powder Inhalation. Molecular Pharmaceutics. PMID 30925839 DOI: 10.1021/Acs.Molpharmaceut.8B00907  0.488
2019 Ma X, Huang S, Lowinger MB, Liu X, Lu X, Su Y, Williams RO. Influence of Mechanical and Thermal Energy on Nifedipine Amorphous Solid Dispersions Prepared by Hot Melt Extrusion: Preparation and Physical Stability. International Journal of Pharmaceutics. PMID 30858115 DOI: 10.1016/J.Ijpharm.2019.03.014  0.469
2019 Jermain SV, Miller D, Spangenberg A, Lu X, Moon C, Su Y, Williams RO. Homogeneity of Amorphous Solid Dispersions - An Example with KinetiSol®. Drug Development and Industrial Pharmacy. 1-35. PMID 30653376 DOI: 10.1080/03639045.2019.1569037  0.565
2019 Chen Q, Xu S, Lu X, Boeri MV, Pepelyayeva Y, Diaz EL, Soni S, Allaire M, Forstner MB, Bahnson BJ, Rozovsky S. 77Se NMR Probes the Protein Environmentof Selenomethionine Journal of Physical Chemistry B. DOI: 10.1021/Acs.Jpcb.9B07466.S001  0.421
2018 Lowinger MB, Su Y, Lu X, Williams RO, Zhang F. Can Drug Release Rate from Implants Be Tailored Using Poly(urethane) Mixtures? International Journal of Pharmaceutics. PMID 30529658 DOI: 10.1016/J.Ijpharm.2018.11.067  0.525
2018 Lu X, Xu W, Hanada M, Jermain SV, Williams RO, Su Y. Solid-state NMR analysis of crystalline and amorphous Indomethacin: An experimental protocol for full resonance assignments. Journal of Pharmaceutical and Biomedical Analysis. 165: 47-55. PMID 30503894 DOI: 10.1016/J.Jpba.2018.11.001  0.611
2018 Hanada M, Jermain SV, Lu X, Su Y, Williams RO. Predicting Physical Stability of Ternary Amorphous Solid Dispersion Using Specific Mechanical Energy in a Hot Melt Extrusion Process. International Journal of Pharmaceutics. PMID 30006310 DOI: 10.1016/J.Ijpharm.2018.07.029  0.575
2018 Fritz M, Quinn CM, Wang M, Hou G, Lu X, Koharudin LMI, Struppe J, Case DA, Polenova T, Gronenborn AM. Determination of accurate backbone chemical shift tensors in microcrystalline proteins by integrating MAS NMR and QM/MM. Physical Chemistry Chemical Physics : Pccp. PMID 29577158 DOI: 10.1039/C8Cp00647D  0.392
2017 Struppe J, Quinn CM, Lu M, Wang M, Hou G, Lu X, Kraus J, Andreas LB, Stanek J, Lalli D, Lesage A, Pintacuda G, Maas W, Gronenborn AM, Polenova T. Expanding the horizons for structural analysis of fully protonated protein assemblies by NMR spectroscopy at MAS frequencies above 100 kHz. Solid State Nuclear Magnetic Resonance. PMID 28732673 DOI: 10.1016/J.Ssnmr.2017.07.001  0.425
2017 Guo C, Hou G, Lu X, Polenova T. Mapping protein-protein interactions by double-REDOR-filtered magic angle spinning NMR spectroscopy. Journal of Biomolecular Nmr. PMID 28120201 DOI: 10.1007/S10858-016-0086-1  0.357
2016 Fritz M, Quinn CM, Wang M, Hou G, Lu X, Koharudin LM, Polenova T, Gronenborn AM. Toward Closing the Gap: Quantum Mechanical Calculations and Experimentally Measured Chemical Shifts of a Microcrystalline Lectin. The Journal of Physical Chemistry. B. PMID 28001418 DOI: 10.1021/Acs.Jpcb.6B09479  0.403
2016 Lu X, Zhang H, Lu M, Vega AJ, Hou G, Polenova T. Improving dipolar recoupling for site-specific structural and dynamics studies in biosolids NMR: windowed RN-symmetry sequences. Physical Chemistry Chemical Physics : Pccp. PMID 26776070 DOI: 10.1039/C5Cp07818K  0.426
2015 Yan S, Guo C, Hou G, Zhang H, Lu X, Williams JC, Polenova T. Atomic-resolution structure of the CAP-Gly domain of dynactin on polymeric microtubules determined by magic angle spinning NMR spectroscopy. Proceedings of the National Academy of Sciences of the United States of America. 112: 14611-6. PMID 26604305 DOI: 10.1073/Pnas.1509852112  0.35
2015 Lu X, Guo C, Hou G, Polenova T. Combined zero-quantum and spin-diffusion mixing for efficient homonuclear correlation spectroscopy under fast MAS: broadband recoupling and detection of long-range correlations. Journal of Biomolecular Nmr. 61: 7-20. PMID 25420598 DOI: 10.1007/S10858-014-9875-6  0.401
2014 Guo C, Hou G, Lu X, O'Hare B, Struppe J, Polenova T. Fast magic angle spinning NMR with heteronucleus detection for resonance assignments and structural characterization of fully protonated proteins. Journal of Biomolecular Nmr. 60: 219-29. PMID 25381566 DOI: 10.1007/S10858-014-9870-Y  0.402
2014 Hou G, Lu X, Vega AJ, Polenova T. Accurate measurement of heteronuclear dipolar couplings by phase-alternating R-symmetry (PARS) sequences in magic angle spinning NMR spectroscopy. The Journal of Chemical Physics. 141: 104202. PMID 25217909 DOI: 10.1063/1.4894226  0.409
2013 Lu X, Tankamony AS, Trébosc J, Lafon O, Amoureux JP. Probing proximities between different quadrupolar isotopes using multi-pulse cross-polarization. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 228: 148-58. PMID 23313781 DOI: 10.1016/J.Jmr.2012.12.005  0.312
2013 Lu X, Trébosc J, Lafon O, Amoureux J. Measurement of the shortest hetero-nuclear distances in multiple-spin systems using constant-time correlation NMR methods Crystengcomm. 15: 8713-8726. DOI: 10.1039/C3Ce40557E  0.37
2012 Lu X, Lafon O, Trébosc J, Tricot G, Delevoye L, Méar F, Montagne L, Amoureux JP. Observation of proximities between spin-1/2 and quadrupolar nuclei: Which heteronuclear dipolar recoupling method is preferable? Journal of Chemical Physics. 137: 144201-144201. PMID 23061841 DOI: 10.1063/1.4753987  0.377
2012 Lu X, Lafon O, Trébosc J, Thankamony AS, Nishiyama Y, Gan Z, Madhu PK, Amoureux JP. Detailed analysis of the TIMES and TIMES0 high-resolution MAS methods for high-resolution proton NMR. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 223: 219-27. PMID 22985982 DOI: 10.1016/J.Jmr.2012.07.015  0.371
2012 Lu X, Lafon O, Trébosc J, Amoureux JP. Detailed analysis of the S-RESPDOR solid-state NMR method for inter-nuclear distance measurement between spin-1/2 and quadrupolar nuclei. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 215: 34-49. PMID 22257437 DOI: 10.1016/J.Jmr.2011.12.009  0.387
2012 Nishiyama Y, Lu X, Trébosc J, Lafon O, Gan Z, Madhu PK, Amoureux JP. Practical choice of ¹H-¹H decoupling schemes in through-bond ¹H-{X} HMQC experiments at ultra-fast MAS. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 214: 151-8. PMID 22130518 DOI: 10.1016/J.Jmr.2011.10.014  0.361
2012 Lilly Thankamony AS, Lafon O, Lu X, Aussenac F, Rosay M, Trébosc J, Vezin H, Amoureux J. Solvent-Free High-Field Dynamic Nuclear Polarization of Mesoporous Silica Functionalized with TEMPO Applied Magnetic Resonance. 43: 237-250. DOI: 10.1007/S00723-012-0364-3  0.378
2011 Lafon O, Rosay M, Aussenac F, Lu X, Trébosc J, Cristini O, Kinowski C, Touati N, Vezin H, Amoureux JP. Beyond the silica surface by direct silicon-29 dynamic nuclear polarization. Angewandte Chemie (International Ed. in English). 50: 8367-70. PMID 21770004 DOI: 10.1002/Anie.201101841  0.391
2011 Wang Q, Lu X, Lafon O, Trébosc J, Deng F, Hu B, Chen Q, Amoureux JP. Measurement of 13C-1H dipolar couplings in solids by using ultra-fast magic-angle spinning NMR spectroscopy with symmetry-based sequences. Physical Chemistry Chemical Physics : Pccp. 13: 5967-73. PMID 21336406 DOI: 10.1039/C0Cp01907K  0.418
2010 Chen L, Lu X, Wang Q, Lafon O, Trébosc J, Deng F, Amoureux JP. Distance measurement between a spin-1/2 and a half-integer quadrupolar nuclei by solid-state NMR using exact analytical expressions. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 206: 269-73. PMID 20678947 DOI: 10.1016/J.Jmr.2010.07.009  0.355
2010 Cui X, Jiang Y, Yang C, Lu X, Chen H, Mao S, Liu M, Yuan H, Luo P, Du Y. Mechanism of the mixed surfactant micelle formation. The Journal of Physical Chemistry. B. 114: 7808-16. PMID 20481561 DOI: 10.1021/Jp101032Z  0.339
2009 Jiang Y, Lu XY, Chen H, Mao SZ, Liu ML, Luo PY, Du YR. NMR study of the dynamics of cationic gemini surfactant 14-2-14 in mixed solutions with conventional surfactants. The Journal of Physical Chemistry. B. 113: 8357-61. PMID 19462938 DOI: 10.1021/Jp902419U  0.359
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