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Bennett Novitch, Ph.D. - Publications

Affiliations: 
2004-2007 Cell and Developmental Biology University of Michigan Medical School, Ann Arbor, MI, United States 
 2007- Neurobiology University of California, Los Angeles, Los Angeles, CA 
 2007- Broad Stem Cell Research Center University of California, Los Angeles, Los Angeles, CA 
Area:
neural development, spinal cord, cortex, neurogenesis, organoids, neural stem cell, circuit formation, neurodevelopmental disorders, disease modeling
Website:
www.novitchlab.com
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58 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Gupta S, Heinrichs E, Novitch BG, Butler SJ. Investigating the basis of lineage decisions and developmental trajectories in the dorsal spinal cord through pseudotime analyses. Biorxiv : the Preprint Server For Biology. PMID 37546781 DOI: 10.1101/2023.07.24.550380  0.786
2023 Stearns-Reider KM, Hicks MR, Hammond KG, Reynolds JC, Maity A, Kurmangaliyev YZ, Chin J, Stieg AZ, Geisse NA, Hohlbauch S, Kaemmer S, Schmitt LR, Pham TT, Yamauchi K, Novitch BG, et al. Myoscaffolds reveal laminin scarring is detrimental for stem cell function while sarcospan induces compensatory fibrosis. Npj Regenerative Medicine. 8: 16. PMID 36922514 DOI: 10.1038/s41536-023-00287-2  0.466
2022 Watanabe M, Buth JE, Haney JR, Vishlaghi N, Turcios F, Elahi LS, Gu W, Pearson CA, Kurdian A, Baliaouri NV, Collier AJ, Miranda OA, Dunn N, Chen D, Sabri S, ... ... Novitch BG, et al. TGFβ superfamily signaling regulates the state of human stem cell pluripotency and capacity to create well-structured telencephalic organoids. Stem Cell Reports. PMID 36179695 DOI: 10.1016/j.stemcr.2022.08.013  0.711
2022 Gupta S, Kawaguchi R, Heinrichs E, Gallardo S, Castellanos S, Mandric I, Novitch BG, Butler SJ. In vitro atlas of dorsal spinal interneurons reveals Wnt signaling as a critical regulator of progenitor expansion. Cell Reports. 40: 111119. PMID 35858555 DOI: 10.1016/j.celrep.2022.111119  0.807
2022 Li LK, Huang WC, Hsueh YY, Yamauchi K, Olivares N, Davila R, Fang J, Ding X, Zhao W, Soto J, Hasani M, Novitch B, Li S. Intramuscular delivery of neural crest stem cell spheroids enhances neuromuscular regeneration after denervation injury. Stem Cell Research & Therapy. 13: 205. PMID 35578348 DOI: 10.1186/s13287-022-02877-1  0.538
2021 Taniguchi-Ikeda M, Koyanagi-Aoi M, Maruyama T, Takaori T, Hosoya A, Tezuka H, Nagase S, Ishihara T, Kadoshima T, Muguruma K, Ishigaki K, Sakurai H, Mizoguchi A, Novitch BG, Toda T, et al. Restoration of the defect in radial glial fiber migration and cortical plate organization in a brain organoid model of Fukuyama muscular dystrophy. Iscience. 24: 103140. PMID 34632335 DOI: 10.1016/j.isci.2021.103140  0.683
2021 Allison T, Langerman J, Sabri S, Otero-Garcia M, Lund A, Huang J, Wei X, Samarasinghe RA, Polioudakis D, Mody I, Cobos I, Novitch BG, Geschwind DH, Plath K, Lowry WE. Defining the nature of human pluripotent stem cell-derived interneurons via single-cell analysis. Stem Cell Reports. PMID 34506726 DOI: 10.1016/j.stemcr.2021.08.006  0.824
2021 Samarasinghe RA, Miranda OA, Buth JE, Mitchell S, Ferando I, Watanabe M, Allison TF, Kurdian A, Fotion NN, Gandal MJ, Golshani P, Plath K, Lowry WE, Parent JM, Mody I, ... Novitch BG, et al. Identification of neural oscillations and epileptiform changes in human brain organoids. Nature Neuroscience. PMID 34426698 DOI: 10.1038/s41593-021-00906-5  0.749
2021 Gupta S, Yamauchi K, Novitch BG, Butler SJ. Derivation of dorsal spinal sensory interneurons from human pluripotent stem cells. Star Protocols. 2: 100319. PMID 33659900 DOI: 10.1016/j.xpro.2021.100319  0.624
2020 Pearson CA, Moore DM, Tucker HO, Dekker JD, Hu H, Miquelajáuregui A, Novitch BG. Foxp1 Regulates Neural Stem Cell Self-Renewal and Bias Toward Deep Layer Cortical Fates. Cell Reports. 30: 1964-1981.e3. PMID 32049024 DOI: 10.1016/j.celrep.2020.01.034  0.521
2019 Andrews MG, Kong J, Novitch BG, Butler SJ. New perspectives on the mechanisms establishing the dorsal-ventral axis of the spinal cord. Current Topics in Developmental Biology. 132: 417-450. PMID 30797516 DOI: 10.1016/Bs.Ctdb.2018.12.010  0.67
2018 Sagner A, Gaber ZB, Delile J, Kong JH, Rousso DL, Pearson CA, Weicksel SE, Melchionda M, Mousavy Gharavy SN, Briscoe J, Novitch BG. Olig2 and Hes regulatory dynamics during motor neuron differentiation revealed by single cell transcriptomics. Plos Biology. 16: e2003127. PMID 29389974 DOI: 10.1371/Journal.Pbio.2003127  0.806
2017 Watanabe M, Buth JE, Vishlaghi N, de la Torre-Ubieta L, Taxidis J, Khakh BS, Coppola G, Pearson CA, Yamauchi K, Gong D, Dai X, Damoiseaux R, Aliyari R, Liebscher S, Schenke-Layland K, ... ... Novitch BG, et al. Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection. Cell Reports. 21: 517-532. PMID 29020636 DOI: 10.1016/J.Celrep.2017.09.047  0.74
2017 Sangwan S, Zhao A, Adams KL, Jayson CK, Sawaya MR, Guenther EL, Pan AC, Ngo J, Moore DM, Soriaga AB, Do TD, Goldschmidt L, Nelson R, Bowers MT, Koehler CM, ... ... Novitch BG, et al. Atomic structure of a toxic, oligomeric segment of SOD1 linked to amyotrophic lateral sclerosis (ALS). Proceedings of the National Academy of Sciences of the United States of America. PMID 28760994 DOI: 10.1073/Pnas.1705091114  0.556
2017 Varadarajan SG, Kong JH, Phan KD, Kao TJ, Panaitof SC, Cardin J, Eltzschig H, Kania A, Novitch BG, Butler SJ. Netrin1 Produced by Neural Progenitors, Not Floor Plate Cells, Is Required for Axon Guidance in the Spinal Cord. Neuron. PMID 28434801 DOI: 10.1016/J.Neuron.2017.03.007  0.702
2017 Li C, Deng YQ, Wang S, Ma F, Aliyari R, Huang XY, Zhang NN, Watanabe M, Dong HL, Liu P, Li XF, Ye Q, Tian M, Hong S, Fan J, ... ... Novitch BG, et al. 25-Hydroxycholesterol Protects Host against Zika Virus Infection and Its Associated Microcephaly in a Mouse Model. Immunity. PMID 28314593 DOI: 10.1016/J.Immuni.2017.02.012  0.7
2017 Huang C, Su T, Xue Y, Cheng C, Lay FD, McKee RA, Li M, Vashisht A, Wohlschlegel J, Novitch BG, Plath K, Kurdistani SK, Carey M. Cbx3 maintains lineage specificity during neural differentiation. Genes & Development. 31: 241-246. PMID 28270516 DOI: 10.1101/Gad.292169.116  0.316
2015 Linares AJ, Lin CH, Damianov A, Adams KL, Novitch BG, Black DL. The splicing regulator PTBP1 controls the activity of the transcription factor Pbx1 during neuronal differentiation. Elife. 4. PMID 26705333 DOI: 10.7554/Elife.09268  0.633
2015 Kong JH, Yang L, Dessaud E, Chuang K, Moore DM, Rohatgi R, Briscoe J, Novitch BG. Notch activity modulates the responsiveness of neural progenitors to sonic hedgehog signaling. Developmental Cell. 33: 373-87. PMID 25936505 DOI: 10.1016/J.Devcel.2015.03.005  0.753
2015 Adams KL, Rousso DL, Umbach JA, Novitch BG. Foxp1-mediated programming of limb-innervating motor neurons from mouse and human embryonic stem cells. Nature Communications. 6: 6778. PMID 25868900 DOI: 10.1038/Ncomms7778  0.804
2014 Pearson CA, Butler SJ, Novitch BG. Neuronal organization: unsticking the cadherin code. Current Biology : Cb. 24: R1127-9. PMID 25465332 DOI: 10.1016/j.cub.2014.10.034  0.588
2014 Niewiadomski P, Kong JH, Ahrends R, Ma Y, Humke EW, Khan S, Teruel MN, Novitch BG, Rohatgi R. Gli protein activity is controlled by multisite phosphorylation in vertebrate Hedgehog signaling. Cell Reports. 6: 168-81. PMID 24373970 DOI: 10.1016/J.Celrep.2013.12.003  0.515
2013 Xu B, Hrycaj SM, McIntyre DC, Baker NC, Takeuchi JK, Jeannotte L, Gaber ZB, Novitch BG, Wellik DM. Hox5 interacts with Plzf to restrict Shh expression in the developing forelimb. Proceedings of the National Academy of Sciences of the United States of America. 110: 19438-43. PMID 24218595 DOI: 10.1073/Pnas.1315075110  0.744
2013 Gaber ZB, Butler SJ, Novitch BG. PLZF regulates fibroblast growth factor responsiveness and maintenance of neural progenitors. Plos Biology. 11: e1001676. PMID 24115909 DOI: 10.1371/Journal.Pbio.1001676  0.823
2013 Kong JH, Butler SJ, Novitch BG. My brain told me to do it. Developmental Cell. 25: 436-8. PMID 23763945 DOI: 10.1016/J.Devcel.2013.05.019  0.668
2013 Jacob J, Kong J, Moore S, Milton C, Sasai N, Gonzalez-Quevedo R, Terriente J, Imayoshi I, Kageyama R, Kageyama R, Wilkinson DG, Novitch BG, Briscoe J. Retinoid acid specifies neuronal identity through graded expression of Ascl1. Current Biology : Cb. 23: 412-8. PMID 23416099 DOI: 10.1016/J.Cub.2013.01.046  0.702
2012 Roy A, Francius C, Rousso DL, Seuntjens E, Debruyn J, Luxenhofer G, Huber AB, Huylebroeck D, Novitch BG, Clotman F. Onecut transcription factors act upstream of Isl1 to regulate spinal motoneuron diversification. Development (Cambridge, England). 139: 3109-19. PMID 22833130 DOI: 10.1242/dev.078501  0.722
2012 Umbach JA, Adams KL, Gundersen CB, Novitch BG. Functional neuromuscular junctions formed by embryonic stem cell-derived motor neurons. Plos One. 7: e36049. PMID 22574134 DOI: 10.1371/Journal.Pone.0036049  0.652
2012 Rousso DL, Pearson CA, Gaber ZB, Miquelajauregui A, Li S, Portera-Cailliau C, Morrisey EE, Novitch BG. Foxp-mediated suppression of N-cadherin regulates neuroepithelial character and progenitor maintenance in the CNS. Neuron. 74: 314-30. PMID 22542185 DOI: 10.1016/J.Neuron.2012.02.024  0.815
2012 Kang P, Lee HK, Glasgow SM, Finley M, Donti T, Gaber ZB, Graham BH, Foster AE, Novitch BG, Gronostajski RM, Deneen B. Sox9 and NFIA coordinate a transcriptional regulatory cascade during the initiation of gliogenesis. Neuron. 74: 79-94. PMID 22500632 DOI: 10.1016/J.Neuron.2012.01.024  0.774
2011 Skaggs K, Martin DM, Novitch BG. Regulation of spinal interneuron development by the Olig-related protein Bhlhb5 and Notch signaling. Development (Cambridge, England). 138: 3199-211. PMID 21750031 DOI: 10.1242/Dev.057281  0.774
2011 Gaber ZB, Novitch BG. All the embryo's a stage, and Olig2 in its time plays many parts. Neuron. 69: 833-5. PMID 21382543 DOI: 10.1016/J.Neuron.2011.02.037  0.773
2010 Palmesino E, Rousso DL, Kao TJ, Klar A, Laufer E, Uemura O, Okamoto H, Novitch BG, Kania A. Foxp1 and lhx1 coordinate motor neuron migration with axon trajectory choice by gating Reelin signalling. Plos Biology. 8: e1000446. PMID 20711475 DOI: 10.1371/Journal.Pbio.1000446  0.79
2010 Dessaud E, Ribes V, Balaskas N, Yang LL, Pierani A, Kicheva A, Novitch BG, Briscoe J, Sasai N. Dynamic assignment and maintenance of positional identity in the ventral neural tube by the morphogen sonic hedgehog. Plos Biology. 8: e1000382. PMID 20532235 DOI: 10.1371/Journal.Pbio.1000382  0.731
2010 Ribes V, Balaskas N, Sasai N, Cruz C, Dessaud E, Cayuso J, Tozer S, Yang LL, Novitch B, Marti E, Briscoe J. Distinct Sonic Hedgehog signaling dynamics specify floor plate and ventral neuronal progenitors in the vertebrate neural tube. Genes & Development. 24: 1186-200. PMID 20516201 DOI: 10.1101/gad.559910  0.64
2009 Novitch BG, Butler SJ. Reducing the mystery of neuronal differentiation. Cell. 138: 1062-4. PMID 19766560 DOI: 10.1016/j.cell.2009.09.001  0.494
2009 Vue TY, Bluske K, Alishahi A, Yang LL, Koyano-Nakagawa N, Novitch B, Nakagawa Y. Sonic hedgehog signaling controls thalamic progenitor identity and nuclei specification in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 4484-97. PMID 19357274 DOI: 10.1523/Jneurosci.0656-09.2009  0.563
2009 Karumbayaram S, Novitch BG, Patterson M, Umbach JA, Richter L, Lindgren A, Conway AE, Clark AT, Goldman SA, Plath K, Wiedau-Pazos M, Kornblum HI, Lowry WE. Directed differentiation of human-induced pluripotent stem cells generates active motor neurons. Stem Cells (Dayton, Ohio). 27: 806-11. PMID 19350680 DOI: 10.1002/Stem.31  0.342
2009 Yang LL, Gaber ZB, Weicksel SE, Dessaud E, Rousso DL, Briscoe J, Novitch BG. Antagonistic actions of Olig2 and the Notch signaling pathway in the assignment of neuronal and glial cell fates Developmental Biology. 331: 389. DOI: 10.1016/J.Ydbio.2009.05.022  0.789
2008 Rousso DL, Gaber ZB, Wellik D, Morrisey EE, Novitch BG. Coordinated actions of the forkhead protein Foxp1 and Hox proteins in the columnar organization of spinal motor neurons. Neuron. 59: 226-40. PMID 18667151 DOI: 10.1016/J.Neuron.2008.06.025  0.794
2008 Briscoe J, Novitch BG. Regulatory pathways linking progenitor patterning, cell fates and neurogenesis in the ventral neural tube. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 363: 57-70. PMID 17282991 DOI: 10.1098/rstb.2006.2012  0.606
2008 Rousso DL, Gaber ZB, Wellik D, Morrisey EE, Novitch BG. Coordinated Actions of the Forkhead Protein Foxp1 and Hox Proteins in the Columnar Organization of Spinal Motor Neurons (DOI:10.1016/j.neuron.2008.06.025) Neuron. 59: 674-675. DOI: 10.1016/J.Neuron.2008.08.002  0.785
2007 Dessaud E, Yang LL, Hill K, Cox B, Ulloa F, Ribeiro A, Mynett A, Novitch BG, Briscoe J. Interpretation of the sonic hedgehog morphogen gradient by a temporal adaptation mechanism. Nature. 450: 717-20. PMID 18046410 DOI: 10.1038/nature06347  0.614
2006 Mukouyama YS, Deneen B, Lukaszewicz A, Novitch BG, Wichterle H, Jessell TM, Anderson DJ. Olig2+ neuroepithelial motoneuron progenitors are not multipotent stem cells in vivo. Proceedings of the National Academy of Sciences of the United States of America. 103: 1551-6. PMID 16432183 DOI: 10.1073/Pnas.0510658103  0.743
2006 Skaggs K, Yang M, Novitch B. Characterization of a novel bHLH protein in the developing spinal cord Developmental Biology. 295: 404-405. DOI: 10.1016/J.Ydbio.2006.04.241  0.725
2006 Gaber ZB, Reddy T, Assis P, Novitch BG. A microarray for Olig2 targets identifies potential regulators of neural progenitor cell maintenance in the developing spinal cord Developmental Biology. 295: 404. DOI: 10.1016/J.Ydbio.2006.04.240  0.772
2006 Novitch BG, Weicksel SE, Yang LL, Reddy T, Teboul L, Guillemot F, Jessell M. Olig2-mediated repression of Hes genes determines the spatial pattern and timing of neurogenesis in the spinal cord Developmental Biology. 295: 382. DOI: 10.1016/J.YDBIO.2006.04.173  0.414
2005 Marshall CA, Novitch BG, Goldman JE. Olig2 directs astrocyte and oligodendrocyte formation in postnatal subventricular zone cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 7289-98. PMID 16093378 DOI: 10.1523/JNEUROSCI.1924-05.2005  0.345
2003 Novitch BG, Wichterle H, Jessell TM, Sockanathan S. A requirement for retinoic acid-mediated transcriptional activation in ventral neural patterning and motor neuron specification. Neuron. 40: 81-95. PMID 14527435 DOI: 10.1016/J.Neuron.2003.08.006  0.821
2003 Bylund M, Andersson E, Novitch BG, Muhr J. Vertebrate neurogenesis is counteracted by Sox1-3 activity. Nature Neuroscience. 6: 1162-8. PMID 14517545 DOI: 10.1038/nn1131  0.354
2003 Qu J, Li X, Novitch BG, Zheng Y, Kohn M, Xie JM, Kozinn S, Bronson R, Beg AA, Minden A. PAK4 kinase is essential for embryonic viability and for proper neuronal development. Molecular and Cellular Biology. 23: 7122-33. PMID 14517283 DOI: 10.1128/Mcb.23.20.7122-7133.2003  0.317
2001 Novitch BG, Chen AI, Jessell TM. Coordinate regulation of motor neuron subtype identity and pan-neuronal properties by the bHLH repressor Olig2. Neuron. 31: 773-89. PMID 11567616 DOI: 10.1016/S0896-6273(01)00407-X  0.708
1999 Novitch BG, Spicer DB, Kim PS, Cheung WL, Lassar AB. pRb is required for MEF2-dependent gene expression as well as cell-cycle arrest during skeletal muscle differentiation. Current Biology : Cb. 9: 449-59. PMID 10322110 DOI: 10.1016/S0960-9822(99)80210-3  0.622
1998 Sellers WR, Novitch BG, Miyake S, Heith A, Otterson GA, Kaye FJ, Lassar AB, Kaelin WG. Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth. Genes & Development. 12: 95-106. PMID 9420334 DOI: 10.1101/Gad.12.1.95  0.606
1996 Skapek SX, Rhee J, Kim PS, Novitch BG, Lassar AB. Cyclin-mediated inhibition of muscle gene expression via a mechanism that is independent of pRB hyperphosphorylation. Molecular and Cellular Biology. 16: 7043-53. PMID 8943359  0.58
1996 Novitch BG, Mulligan GJ, Jacks T, Lassar AB. Skeletal muscle cells lacking the retinoblastoma protein display defects in muscle gene expression and accumulate in S and G2 phases of the cell cycle. The Journal of Cell Biology. 135: 441-56. PMID 8896600 DOI: 10.1083/Jcb.135.2.441  0.613
1995 Halevy O, Novitch BG, Spicer DB, Skapek SX, Rhee J, Hannon GJ, Beach D, Lassar AB. Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD. Science (New York, N.Y.). 267: 1018-21. PMID 7863327 DOI: 10.1126/Science.7863327  0.597
1994 Lassar AB, Skapek SX, Novitch B. Regulatory mechanisms that coordinate skeletal muscle differentiation and cell cycle withdrawal. Current Opinion in Cell Biology. 6: 788-94. PMID 7880524 DOI: 10.1016/0955-0674(94)90046-9  0.637
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