Lai-Xi Wang - Publications

Affiliations: 
Chemistry and Biochemistry University of Maryland, College Park, College Park, MD 

142 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Yang Q, Chen H, Ou C, Zheng Z, Zhang X, Liu Y, Zong G, Wang LX. Evaluation of Two Chemoenzymatic Glycan Remodeling Approaches to Generate Site-Specific Antibody-Drug Conjugates. Antibodies (Basel, Switzerland). 12. PMID 37987249 DOI: 10.3390/antib12040071  0.318
2023 Donahue TC, Ou C, Yang Q, Flinko R, Zhang X, Zong G, Lewis GK, Wang LX. Synthetic Site-Specific Antibody-Ligand Conjugates Promote Asialoglycoprotein Receptor-Mediated Degradation of Extracellular Human PCSK9. Acs Chemical Biology. PMID 37368876 DOI: 10.1021/acschembio.3c00229  0.333
2023 Trastoy B, Du JJ, Cifuente JO, Rudolph L, García-Alija M, Klontz EH, Deredge D, Sultana N, Huynh CG, Flowers MW, Li C, Sastre DE, Wang LX, Corzana F, Mallagaray A, et al. Mechanism of antibody-specific deglycosylation and immune evasion by Streptococcal IgG-specific endoglycosidases. Nature Communications. 14: 1705. PMID 36973249 DOI: 10.1038/s41467-023-37215-3  0.373
2022 Kao KS, Gupta A, Zong G, Li C, Kerschbaumer I, Borghi S, Achkar JM, Bournazos S, Wang LX, Ravetch JV. Synthetic nanobodies as tools to distinguish IgG Fc glycoforms. Proceedings of the National Academy of Sciences of the United States of America. 119: e2212658119. PMID 36409896 DOI: 10.1073/pnas.2212658119  0.326
2022 Huang K, Li C, Zong G, Prabhu SK, Chapla DG, Moremen KW, Wang LX. Site-selective sulfation of N-glycans by human GlcNAc-6-O-sulfotransferase 1 (CHST2) and chemoenzymatic synthesis of sulfated antibody glycoforms. Bioorganic Chemistry. 128: 106070. PMID 35939855 DOI: 10.1016/j.bioorg.2022.106070  0.427
2022 Donahue TC, Zong G, O'Brien NA, Ou C, Gildersleeve JC, Wang LX. Synthesis and Immunological Study of N-Glycan-Bacteriophage Qβ Conjugates Reveal Dominant Antibody Responses to the Conserved Chitobiose Core. Bioconjugate Chemistry. PMID 35687881 DOI: 10.1021/acs.bioconjchem.2c00211  0.414
2022 Zhang X, Ou C, Liu H, Wang LX. Synthesis and Evaluation of Three Azide-Modified Disaccharide Oxazolines as Enzyme Substrates for Single-Step Fc Glycan-Mediated Antibody-Drug Conjugation. Bioconjugate Chemistry. PMID 35543724 DOI: 10.1021/acs.bioconjchem.2c00142  0.341
2022 Zhang X, Liu H, He J, Ou C, Donahue TC, Muthana MM, Su L, Wang LX. Site-Specific Chemoenzymatic Conjugation of High-Affinity M6P Glycan Ligands to Antibodies for Targeted Protein Degradation. Acs Chemical Biology. PMID 35316032 DOI: 10.1021/acschembio.1c00751  0.374
2022 Ou C, Prabhu SK, Zhang X, Zong G, Yang Q, Wang LX. Synthetic antibody-rhamnose cluster conjugates show potent complement-dependent cell killing by recruiting natural antibodies. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 35106843 DOI: 10.1002/chem.202200146  0.329
2022 Trastoy B, Du JJ, García-Alija M, Li C, Klontz EH, Wang LX, Sundberg EJ, Guerin ME. Sculpting therapeutic monoclonal antibody N-glycans using endoglycosidases. Current Opinion in Structural Biology. 72: 248-259. PMID 34998123 DOI: 10.1016/j.sbi.2021.11.016  0.405
2021 Zong G, Toonstra C, Yang Q, Zhang R, Wang LX. Chemoenzymatic Synthesis and Antibody Binding of HIV-1 V1/V2 Glycopeptide-Bacteriophage Q Conjugates as a Vaccine Candidate. International Journal of Molecular Sciences. 22. PMID 34830420 DOI: 10.3390/ijms222212538  0.338
2021 Wang Q, Wang T, Zhang R, Yang S, McFarland K, Chung CY, Jia H, Wang LX, Cipollo JF, Betenbaugh MJ. The interplay of protein engineering and glycoengineering to fine-tune antibody glycosylation and its impact on effector functions. Biotechnology and Bioengineering. PMID 34647616 DOI: 10.1002/bit.27953  0.389
2021 Zhang X, Ou C, Liu H, Prabhu SK, Li C, Yang Q, Wang LX. General and Robust Chemoenzymatic Method for Glycan-Mediated Site-Specific Labeling and Conjugation of Antibodies: Facile Synthesis of Homogeneous Antibody-Drug Conjugates. Acs Chemical Biology. PMID 34569782 DOI: 10.1021/acschembio.1c00597  0.365
2021 Ou C, Li C, Zhang R, Yang Q, Zong G, Dai Y, Francis RL, Bournazos S, Ravetch JV, Wang LX. One-Pot Conversion of Free Sialoglycans to Functionalized Glycan Oxazolines and Efficient Synthesis of Homogeneous Antibody-Drug Conjugates through Site-Specific Chemoenzymatic Glycan Remodeling. Bioconjugate Chemistry. PMID 34351736 DOI: 10.1021/acs.bioconjchem.1c00314  0.33
2021 Trastoy B, Du JJ, Li C, García-Alija M, Klontz EH, Roberts BR, Donahue TC, Wang LX, Sundberg EJ, Guerin ME. GH18 ENDO-β-N-ACETYLGLUCOSAMINIDASES USE DISTINCT MECHANISMS TO PROCESS HYBRID-TYPE N-LINKED GLYCANS. The Journal of Biological Chemistry. 101011. PMID 34324829 DOI: 10.1016/j.jbc.2021.101011  0.313
2021 Zong G, Li C, Prabhu SK, Zhang R, Zhang X, Wang LX. A facile chemoenzymatic synthesis of SARS-CoV-2 glycopeptides for probing glycosylation functions. Chemical Communications (Cambridge, England). 57: 6804-6807. PMID 34236361 DOI: 10.1039/d1cc02790e  0.314
2021 Prabhu SK, Li C, Zong G, Zhang R, Wang LX. Comparative studies on the substrate specificity and defucosylation activity of three α-l-fucosidases using synthetic fucosylated glycopeptides and glycoproteins as substrates. Bioorganic & Medicinal Chemistry. 42: 116243. PMID 34126284 DOI: 10.1016/j.bmc.2021.116243  0.33
2021 Li C, Chong G, Zong G, Knorr DA, Bournazos S, Aytenfisu AH, Henry GK, Ravetch JV, MacKerell AD, Wang LX. Site-Selective Chemoenzymatic Modification on the Core Fucose of an Antibody Enhances Its Fcγ Receptor Affinity and ADCC Activity. Journal of the American Chemical Society. PMID 33977722 DOI: 10.1021/jacs.1c03174  0.361
2021 Zhang R, Yang Q, Boruah BM, Zong G, Li C, Chapla D, Yang JY, Moremen K, Wang LX. Appropriate aglycone modification significantly expands the glycan substrate acceptability of α1,6-fucosyltransferase (FUT8). The Biochemical Journal. PMID 33734311 DOI: 10.1042/BCJ20210138  0.31
2020 Chen X, Shi M, Tong X, Kim HK, Wang LX, Schneewind O, Missiakas D. Glycosylation-dependent opsonophagocytic activity of staphylococcal protein A antibodies. Proceedings of the National Academy of Sciences of the United States of America. PMID 32855300 DOI: 10.1073/Pnas.2003621117  0.445
2020 Borghi S, Bournazos S, Thulin NK, Li C, Gajewski A, Sherwood RW, Zhang S, Harris E, Jagannathan P, Wang LX, Ravetch JV, Wang TT. FcRn, but not FcγRs, drives maternal-fetal transplacental transport of human IgG antibodies. Proceedings of the National Academy of Sciences of the United States of America. PMID 32461366 DOI: 10.1073/Pnas.2004325117  0.386
2020 Trastoy B, Du JJ, Klontz EH, Li C, Cifuente JO, Wang LX, Sundberg EJ, Guerin ME. Structural basis of mammalian high-mannose N-glycan processing by human gut Bacteroides. Nature Communications. 11: 899. PMID 32060313 DOI: 10.1038/S41467-020-14754-7  0.383
2020 Zong G, Li C, Wang LX. Chemoenzymatic Synthesis of HIV-1 Glycopeptide Antigens. Methods in Molecular Biology (Clifton, N.J.). 2103: 249-262. PMID 31879931 DOI: 10.1007/978-1-0716-0227-0_17  0.439
2019 Klontz EH, Trastoy B, Deredge D, Fields JK, Li C, Orwenyo J, Marina A, Beadenkopf R, Günther S, Flores J, Wintrode PL, Wang LX, Guerin ME, Sundberg EJ. Molecular Basis of Broad Spectrum -Glycan Specificity and Processing of Therapeutic IgG Monoclonal Antibodies by Endoglycosidase S2. Acs Central Science. 5: 524-538. PMID 30937380 DOI: 10.2210/Pdb6E58/Pdb  0.478
2019 Wang LX, Tong X, Li C, Giddens JP, Li T. Glycoengineering of Antibodies for Modulating Functions. Annual Review of Biochemistry. PMID 30917003 DOI: 10.1146/Annurev-Biochem-062917-012911  0.785
2019 Zhang R, Cai H, Orwenyo J, Giddens J, Yang Q, LaBranche CC, Montefiori DC, Wang L. PI-6 Construction and analysis of V3 glycopeptide antigens for HIV-1 vaccine design Jaids Journal of Acquired Immune Deficiency Syndromes. 81: 78. DOI: 10.1097/01.Qai.0000558039.75095.Df  0.715
2018 Giddens JP, Lomino JV, DiLillo DJ, Ravetch JV, Wang LX. Site-selective chemoenzymatic glycoengineering of Fab and Fc glycans of a therapeutic antibody. Proceedings of the National Academy of Sciences of the United States of America. PMID 30397147 DOI: 10.1073/Pnas.1812833115  0.802
2018 Cai H, Zhang R, Orwenyo J, Giddens JP, Yang Q, LaBranche CC, Montefiori D, Wang LX. Synthetic HIV V3 Glycopeptide Immunogen Carrying a N334 N-Glycan Induces Glycan-dependent Antibodies with Promiscuous Site Recognition. Journal of Medicinal Chemistry. PMID 30384610 DOI: 10.1021/Acs.Jmedchem.8B01290  0.774
2018 Li C, Li T, Wang LX. Chemoenzymatic Defucosylation of Therapeutic Antibodies for Enhanced Effector Functions Using Bacterial α-Fucosidases. Methods in Molecular Biology (Clifton, N.J.). 1827: 367-380. PMID 30196507 DOI: 10.1007/978-1-4939-8648-4_19  0.482
2018 Li C, Wang LX. Chemoenzymatic Methods for the Synthesis of Glycoproteins. Chemical Reviews. PMID 30141327 DOI: 10.1021/Acs.Chemrev.8B00238  0.372
2018 Tong X, Li T, Li C, Wang LX. Generation and Comparative Kinetic Analysis of New Glycosynthase Mutants From Streptococcus pyogenes Endoglycosidases For Antibody Glycoengineering. Biochemistry. PMID 30102520 DOI: 10.1021/Acs.Biochem.8B00719  0.384
2018 Cai H, Zhang R, Orwenyo J, Giddens J, Yang Q, LaBranche CC, Montefiori DC, Wang LX. Multivalent Antigen Presentation Enhances the Immunogenicity of a Synthetic Three-Component HIV-1 V3 Glycopeptide Vaccine. Acs Central Science. 4: 582-589. PMID 29806004 DOI: 10.1021/Acscentsci.8B00060  0.76
2018 Trastoy B, Klontz E, Orwenyo J, Marina A, Wang LX, Sundberg EJ, Guerin ME. Structural basis for the recognition of complex-type N-glycans by Endoglycosidase S. Nature Communications. 9: 1874. PMID 29760474 DOI: 10.1038/S41467-018-04300-X  0.491
2018 Toonstra C, Wu L, Li C, Wang D, Wang LX. Top-down chemoenzymatic approach to synthesizing diverse high-mannose N-glycans and related neoglycoproteins for carbohydrate microarray analysis. Bioconjugate Chemistry. PMID 29738673 DOI: 10.1021/acs.bioconjchem.8b00145  0.388
2018 Li T, Li C, Quan DN, Bentley WE, Wang LX. Site-specific immobilization of endoglycosidases for streamlined chemoenzymatic glycan remodeling of antibodies. Carbohydrate Research. 458: 77-84. PMID 29475193 DOI: 10.1016/J.Carres.2018.02.007  0.459
2018 Bennett LD, Yang Q, Berquist BR, Giddens JP, Ren Z, Kommineni V, Murray RP, White EL, Holtz BR, Wang LX, Marcel S. Implementation of Glycan Remodeling to Plant-Made Therapeutic Antibodies. International Journal of Molecular Sciences. 19. PMID 29385073 DOI: 10.3390/Ijms19020421  0.762
2017 Li C, Zhu S, Tong X, Ou C, Wang LX. A facile synthesis of a complex type N-glycan thiazoline as an effective inhibitor against the antibody-deactivating endo-β-N-acetylglucosaminidases. Journal of Carbohydrate Chemistry. 36: 336-346. PMID 30930529 DOI: 10.1080/07328303.2017.1403616  0.461
2017 Cai H, Orwenyo J, Giddens JP, Yang Q, Zhang R, LaBranche CC, Montefiori DC, Wang LX. Synthetic Three-Component HIV-1 V3 Glycopeptide Immunogens Induce Glycan-Dependent Antibody Responses. Cell Chemical Biology. PMID 29107699 DOI: 10.1016/J.Chembiol.2017.09.005  0.756
2017 Li C, Zhu S, Ma C, Wang LX. Designer α1,6-Fucosidase Mutants Enable Direct Core Fucosylation of Intact N-Glycopeptides and N-Glycoproteins. Journal of the American Chemical Society. PMID 28990779 DOI: 10.1021/jacs.7b07906  0.332
2017 Yang Q, Wang LX. Chemoenzymatic Glycan Remodeling of Natural and Recombinant Glycoproteins. Methods in Enzymology. 597: 265-281. PMID 28935106 DOI: 10.1016/Bs.Mie.2017.06.006  0.499
2017 Tong X, Li T, Orwenyo J, Toonstra C, Wang LX. One-pot enzymatic glycan remodeling of a therapeutic monoclonal antibody by endoglycosidase S (Endo-S) from Streptococcus pyogenes. Bioorganic & Medicinal Chemistry. PMID 28789910 DOI: 10.1016/j.bmc.2017.07.053  0.334
2017 Tang F, Wang LX, Huang W. Chemoenzymatic synthesis of glycoengineered IgG antibodies and glycosite-specific antibody-drug conjugates. Nature Protocols. 12: 1702-1721. PMID 28749929 DOI: 10.1038/Nprot.2017.058  0.522
2017 Yang Q, Zhang R, Cai H, Wang LX. Revisiting the substrate specificity of mammalian α1,6-fucosyltransferase (FUT8) reveals that it catalyzes core fucosylation of N-glycans lacking α1,3-arm GlcNAc. The Journal of Biological Chemistry. PMID 28729420 DOI: 10.1074/Jbc.M117.804070  0.424
2017 Yang M, Huang J, Simon R, Wang LX, MacKerell AD. Conformational Heterogeneity of the HIV Envelope Glycan Shield. Scientific Reports. 7: 4435. PMID 28667249 DOI: 10.1038/S41598-017-04532-9  0.427
2017 Feng C, Li J, Snyder G, Huang W, Goldblum SE, Chen WH, Wang LX, McClane BA, Cross AS. Antibody against Microbial Neuraminidases Recognizes Human Sialidase 3 (NEU3): the Neuraminidase/Sialidase Superfamily Revisited. Mbio. 8. PMID 28655817 DOI: 10.1128/Mbio.00078-17  0.41
2017 Cai H, Orwenyo J, Guenaga J, Giddens J, Toonstra C, Wyatt RT, Wang LX. Synthetic multivalent V3 glycopeptides display enhanced recognition by glycan-dependent HIV-1 broadly neutralizing antibodies. Chemical Communications (Cambridge, England). PMID 28466900 DOI: 10.1039/C7Cc02059G  0.761
2017 Yang Q, An Y, Zhu S, Zhang R, Loke CM, Cipollo JF, Wang LX. Glycan remodeling of human erythropoietin (EPO) through combined mammalian cell engineering and chemoenzymatic transglycosylation. Acs Chemical Biology. PMID 28452462 DOI: 10.1021/Acschembio.7B00282  0.759
2017 Orwenyo J, Cai H, Giddens J, Amin MN, Toonstra C, Wang LX. Systematic Synthesis and Binding Study of HIV V3 Glycopeptides Reveal the Fine Epitopes of Several Broadly Neutralizing Antibodies. Acs Chemical Biology. PMID 28414420 DOI: 10.1021/Acschembio.7B00319  0.785
2017 Li T, DiLillo DJ, Bournazos S, Giddens JP, Ravetch JV, Wang LX. Modulating IgG effector function by Fc glycan engineering. Proceedings of the National Academy of Sciences of the United States of America. PMID 28289219 DOI: 10.1073/Pnas.1702173114  0.786
2017 Freund NT, Wang H, Scharf L, Nogueira L, Horwitz JA, Bar-On Y, Golijanin J, Sievers SA, Sok D, Cai H, Cesar Lorenzi JC, Halper-Stromberg A, Toth I, Piechocka-Trocha A, Gristick HB, ... ... Wang LX, et al. Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller. Science Translational Medicine. 9. PMID 28100831 DOI: 10.1126/Scitranslmed.Aal2144  0.374
2016 Li C, Wang LX. Endoglycosidases for the Synthesis of Polysaccharides and Glycoconjugates. Advances in Carbohydrate Chemistry and Biochemistry. 73: 73-116. PMID 27816108 DOI: 10.1016/Bs.Accb.2016.07.001  0.347
2016 Yamaguchi T, Amin MN, Toonstra C, Wang LX. Chemoenzymatic Synthesis and Receptor Binding of Mannose-6-Phosphate (M6P)-Containing Glycoprotein Ligands Reveal Unusual Structural Requirements for M6P Receptor Recognition. Journal of the American Chemical Society. PMID 27500601 DOI: 10.1021/Jacs.6B05762  0.364
2016 Hsiao PY, Kalin J, Sun IH, Amin M, Lo YC, Chiang MJ, Giddens J, Sysa-Shah P, Gabrielson K, Wang LX, Powell J, Cole PA. An Fc-Small Molecule Conjugate for Targeted Inhibition of the Adenosine 2A Receptor. Chembiochem : a European Journal of Chemical Biology. PMID 27432157 DOI: 10.1002/Cbic.201600337  0.712
2016 Toonstra C, Amin MN, Wang LX. Site-Selective Chemoenzymatic Glycosylation of an HIV-1 Polypeptide Antigen with Two Distinct N-Glycans via an Orthogonal Protecting Group Strategy. The Journal of Organic Chemistry. PMID 27380452 DOI: 10.1021/Acs.Joc.6B01044  0.481
2016 Li T, Tong X, Yang Q, Giddens JP, Wang LX. Glycosynthase mutants of endoglycosidase S2 show potent transglycosylation activity and remarkably relaxed substrate specificity for antibody glycosylation remodeling. The Journal of Biological Chemistry. PMID 27288408 DOI: 10.1074/Jbc.M116.738765  0.768
2016 Yang Q, Wang LX. Mammalian α1,6-fucosyltransferase (FUT8) is the sole enzyme responsible for the N-acetylglucosaminyltransferase I-independent core fucosylation of high-mannose N-glycans. The Journal of Biological Chemistry. PMID 27008861 DOI: 10.1074/Jbc.M116.720789  0.326
2016 Giddens JP, Lomino JV, Amin MN, Wang LX. Endo-F3 glycosynthase mutants enable chemoenzymatic synthesis of core fucosylated tri-antennary complex-type glycopeptides and glycoproteins. The Journal of Biological Chemistry. PMID 26966183 DOI: 10.1074/Jbc.M116.721597  0.761
2015 Liu R, Giddens J, McClung CM, Magnelli PE, Wang LX, Guthrie EP. Evaluation of a glycoengineered monoclonal antibody via LC-MS analysis in combination with multiple enzymatic digestion. Mabs. 0. PMID 26514686 DOI: 10.1080/19420862.2015.1113361  0.772
2015 Quast I, Keller CW, Maurer MA, Giddens JP, Tackenberg B, Wang LX, Münz C, Nimmerjahn F, Dalakas MC, Lünemann JD. Sialylation of IgG Fc domain impairs complement-dependent cytotoxicity. The Journal of Clinical Investigation. PMID 26436649 DOI: 10.1172/Jci82695  0.758
2015 Giddens JP, Wang LX. Chemoenzymatic Glyco-engineering of Monoclonal Antibodies. Methods in Molecular Biology (Clifton, N.J.). 1321: 375-87. PMID 26082235 DOI: 10.1007/978-1-4939-2760-9_25  0.796
2015 Wang D, Tang J, Tang J, Wang LX. Targeting N-glycan cryptic sugar moieties for broad-spectrum virus neutralization: progress in identifying conserved molecular targets in viruses of distinct phylogenetic origins. Molecules (Basel, Switzerland). 20: 4610-22. PMID 25774492 DOI: 10.3390/Molecules20034610  0.417
2014 Ahmed AA, Giddens J, Pincetic A, Lomino JV, Ravetch JV, Wang LX, Bjorkman PJ. Structural characterization of anti-inflammatory immunoglobulin G Fc proteins. Journal of Molecular Biology. 426: 3166-79. PMID 25036289 DOI: 10.1016/J.Jmb.2014.07.006  0.758
2014 Trastoy B, Lomino JV, Pierce BG, Carter LG, Günther S, Giddens JP, Snyder GA, Weiss TM, Weng Z, Wang LX, Sundberg EJ. Crystal structure of Streptococcus pyogenes EndoS, an immunomodulatory endoglycosidase specific for human IgG antibodies. Proceedings of the National Academy of Sciences of the United States of America. 111: 6714-9. PMID 24753590 DOI: 10.1073/Pnas.1322908111  0.776
2014 Smith EL, Giddens JP, Iavarone AT, Godula K, Wang LX, Bertozzi CR. Chemoenzymatic Fc glycosylation via engineered aldehyde tags. Bioconjugate Chemistry. 25: 788-95. PMID 24702330 DOI: 10.1021/Bc500061S  0.774
2014 Wang D, Bhat R, Sobel RA, Huang W, Wang LX, Olsson T, Steinman L. Uncovering cryptic glycan markers in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). Drug Development Research. 75: 172-88. PMID 24648292 DOI: 10.1002/Ddr.21169  0.352
2014 Chiang MJ, Holbert MA, Kalin JH, Ahn YH, Giddens J, Amin MN, Taylor MS, Collins SL, Chan-Li Y, Waickman A, Hsiao PY, Bolduc D, Leahy DJ, Horton MR, Wang LX, et al. An Fc domain protein-small molecule conjugate as an enhanced immunomodulator. Journal of the American Chemical Society. 136: 3370-3. PMID 24533830 DOI: 10.1021/Ja5006674  0.706
2014 Wang LX, Amin MN. Chemical and chemoenzymatic synthesis of glycoproteins for deciphering functions. Chemistry & Biology. 21: 51-66. PMID 24439206 DOI: 10.1016/J.Chembiol.2014.01.001  0.355
2014 Trastoy B, Lomino J, Wang L, Sundberg E. P-C6 Crystal structure of EndoS, an immunomodulatory endoglycosidase specific for human IgG antibodies. Jaids Journal of Acquired Immune Deficiency Syndromes. 67: 86. DOI: 10.1097/01.Qai.0000456189.57841.00  0.357
2013 Wang D, Dafik L, Nolley R, Huang W, Wolfinger RD, Wang LX, Peehl DM. Anti-Oligomannose Antibodies as Potential Serum Biomarkers of Aggressive Prostate Cancer. Drug Development Research. 74: 65-80. PMID 25152555 DOI: 10.1002/Ddr.21063  0.357
2013 Wang LX. Synthetic carbohydrate antigens for HIV vaccine design. Current Opinion in Chemical Biology. 17: 997-1005. PMID 24466581 DOI: 10.1016/J.Cbpa.2013.10.001  0.387
2013 Amin MN, McLellan JS, Huang W, Orwenyo J, Burton DR, Koff WC, Kwong PD, Wang LX. Synthetic glycopeptides reveal the glycan specificity of HIV-neutralizing antibodies. Nature Chemical Biology. 9: 521-6. PMID 23831758 DOI: 10.1038/Nchembio.1288  0.481
2013 Pancera M, Shahzad-Ul-Hussan S, Doria-Rose NA, McLellan JS, Bailer RT, Dai K, Loesgen S, Louder MK, Staupe RP, Yang Y, Zhang B, Parks R, Eudailey J, Lloyd KE, Blinn J, ... ... Wang LX, et al. Structural basis for diverse N-glycan recognition by HIV-1-neutralizing V1-V2-directed antibody PG16. Nature Structural & Molecular Biology. 20: 804-13. PMID 23708607 DOI: 10.1038/Nsmb.2600  0.396
2013 Orwenyo J, Huang W, Wang LX. Chemoenzymatic synthesis and lectin recognition of a selectively fluorinated glycoprotein. Bioorganic & Medicinal Chemistry. 21: 4768-77. PMID 23566760 DOI: 10.1016/J.Bmc.2013.03.009  0.366
2013 Lomino JV, Naegeli A, Orwenyo J, Amin MN, Aebi M, Wang LX. A two-step enzymatic glycosylation of polypeptides with complex N-glycans. Bioorganic & Medicinal Chemistry. 21: 2262-70. PMID 23477942 DOI: 10.1016/J.Bmc.2013.02.007  0.437
2013 Wang H, Huang W, Orwenyo J, Banerjee A, Vasta GR, Wang LX. Design and synthesis of glycoprotein-based multivalent glyco-ligands for influenza hemagglutinin and human galectin-3. Bioorganic & Medicinal Chemistry. 21: 2037-44. PMID 23411399 DOI: 10.1016/J.Bmc.2013.01.028  0.343
2013 Amin MN, McLellan JS, Huang W, Orwenyo J, Kwong PD, Wang L. D108 Synthetic HIV-1 Glycopeptides Enable Characterization of Fine Epitopes of Broadly Neutralizing Antibody PG9 Journal of Acquired Immune Deficiency Syndromes. 62. DOI: 10.1097/01.Qai.0000429236.01663.55  0.408
2012 Huang W, Giddens J, Fan SQ, Toonstra C, Wang LX. Chemoenzymatic glycoengineering of intact IgG antibodies for gain of functions. Journal of the American Chemical Society. 134: 12308-18. PMID 22747414 DOI: 10.1021/Ja3051266  0.793
2012 Fan SQ, Huang W, Wang LX. Remarkable transglycosylation activity of glycosynthase mutants of endo-D, an endo-β-N-acetylglucosaminidase from Streptococcus pneumoniae. The Journal of Biological Chemistry. 287: 11272-81. PMID 22318728 DOI: 10.1074/Jbc.M112.340497  0.43
2012 Wang LX, Lomino JV. Emerging technologies for making glycan-defined glycoproteins. Acs Chemical Biology. 7: 110-22. PMID 22141574 DOI: 10.1021/Cb200429N  0.362
2011 Zou G, Ochiai H, Huang W, Yang Q, Li C, Wang LX. Chemoenzymatic synthesis and Fcγ receptor binding of homogeneous glycoforms of antibody Fc domain. Presence of a bisecting sugar moiety enhances the affinity of Fc to FcγIIIa receptor. Journal of the American Chemical Society. 133: 18975-91. PMID 22004528 DOI: 10.1021/Ja208390N  0.481
2011 Amin MN, Huang W, Mizanur RM, Wang LX. Convergent synthesis of homogeneous Glc 1Man 9GlcNAc 2-protein and derivatives as ligands of molecular chaperones in protein quality control Journal of the American Chemical Society. 133: 14404-14417. PMID 21819116 DOI: 10.1021/Ja204831Z  0.364
2011 Huang W, Li J, Wang LX. Unusual transglycosylation activity of Flavobacterium meningosepticum endoglycosidases enables convergent chemoenzymatic synthesis of core fucosylated complex N-glycopeptides. Chembiochem : a European Journal of Chemical Biology. 12: 932-41. PMID 21374780 DOI: 10.1002/Cbic.201000763  0.358
2010 Huang W, Zhang X, Ju T, Cummings RD, Wang LX. Expeditious chemoenzymatic synthesis of CD52 glycopeptide antigens. Organic & Biomolecular Chemistry. 8: 5224-33. PMID 20848033 DOI: 10.1039/C0Ob00341G  0.381
2010 Umekawa M, Higashiyama T, Koga Y, Tanaka T, Noguchi M, Kobayashi A, Shoda S, Huang W, Wang LX, Ashida H, Yamamoto K. Efficient transfer of sialo-oligosaccharide onto proteins by combined use of a glycosynthase-like mutant of Mucor hiemalis endoglycosidase and synthetic sialo-complex-type sugar oxazoline. Biochimica Et Biophysica Acta. 1800: 1203-9. PMID 20647032 DOI: 10.1016/J.Bbagen.2010.07.003  0.394
2010 Huang W, Yang Q, Umekawa M, Yamamoto K, Wang LX. Arthrobacter endo-beta-N-acetylglucosaminidase shows transglycosylation activity on complex-type N-glycan oxazolines: one-pot conversion of ribonuclease B to sialylated ribonuclease C. Chembiochem : a European Journal of Chemical Biology. 11: 1350-5. PMID 20486148 DOI: 10.1002/Cbic.201000242  0.412
2010 Yang Q, Li C, Wei Y, Huang W, Wang LX. Expression, glycoform characterization, and antibody-binding of HIV-1 V3 glycopeptide domain fused with human IgG1-Fc. Bioconjugate Chemistry. 21: 875-83. PMID 20369886 DOI: 10.1021/bc9004238  0.4
2010 Schwarz F, Huang W, Li C, Schulz BL, Lizak C, Palumbo A, Numao S, Neri D, Aebi M, Wang LX. A combined method for producing homogeneous glycoproteins with eukaryotic N-glycosylation. Nature Chemical Biology. 6: 264-6. PMID 20190762 DOI: 10.1038/Nchembio.314  0.413
2010 Umekawa M, Li C, Higashiyama T, Huang W, Ashida H, Yamamoto K, Wang LX. Efficient glycosynthase mutant derived from Mucor hiemalis endo-beta-N-acetylglucosaminidase capable of transferring oligosaccharide from both sugar oxazoline and natural N-glycan. The Journal of Biological Chemistry. 285: 511-21. PMID 19880511 DOI: 10.1074/Jbc.M109.059832  0.398
2009 Huang W, Wang D, Yamada M, Wang LX. Chemoenzymatic synthesis and lectin array characterization of a class of N-glycan clusters Journal of the American Chemical Society. 131: 17963-17971. PMID 19916512 DOI: 10.1021/Ja9078539  0.394
2009 Wang LX, Huang W. Enzymatic transglycosylation for glycoconjugate synthesis. Current Opinion in Chemical Biology. 13: 592-600. PMID 19766528 DOI: 10.1016/J.Cbpa.2009.08.014  0.368
2009 Huang W, Groothuys S, Heredia A, Kuijpers BH, Rutjes FP, van Delft FL, Wang LX. Enzymatic glycosylation of triazole-linked GlcNAc/Glc-peptides: synthesis, stability and anti-HIV activity of triazole-linked HIV-1 gp41 glycopeptide C34 analogues. Chembiochem : a European Journal of Chemical Biology. 10: 1234-42. PMID 19353609 DOI: 10.1002/Cbic.200800741  0.394
2009 Luallen RJ, Fu H, Agrawal-Gamse C, Mboudjeka I, Huang W, Lee FH, Wang LX, Doms RW, Geng Y. A yeast glycoprotein shows high-affinity binding to the broadly neutralizing human immunodeficiency virus antibody 2G12 and inhibits gp120 interactions with 2G12 and DC-SIGN. Journal of Virology. 83: 4861-70. PMID 19264785 DOI: 10.1128/Jvi.02537-08  0.412
2009 Newsom-Davis TE, Wang D, Steinman L, Chen PF, Wang LX, Simon AK, Screaton GR. Enhanced immune recognition of cryptic glycan markers in human tumors. Cancer Research. 69: 2018-25. PMID 19223535 DOI: 10.1158/0008-5472.Can-08-3589  0.355
2009 Huang W, Li C, Li B, Umekawa M, Yamamoto K, Zhang X, Wang LX. Glycosynthases enable a highly efficient chemoenzymatic synthesis of N-glycoproteins carrying intact natural N-glycans. Journal of the American Chemical Society. 131: 2214-23. PMID 19199609 DOI: 10.1021/Ja8074677  0.424
2009 Ochiai H, Huang W, Wang LX. Endo-beta-N-acetylglucosaminidase-catalyzed polymerization of beta-Glcp-(1-->4)-GlcpNAc oxazoline: a revisit to enzymatic transglycosylation. Carbohydrate Research. 344: 592-8. PMID 19193364 DOI: 10.1016/J.Carres.2009.01.016  0.302
2009 Chan SL, Voskens CJ, Lin W, Schindler DG, Azimzadeh A, Wang LX, Taylor RJ, Strome SE, Schulze DH. Epitope mapping of a chimeric CD137 mAb: a necessary step for assessing the biologic relevance of non-human primate models. Journal of Molecular Recognition : Jmr. 22: 242-9. PMID 19177494 DOI: 10.1002/Jmr.937  0.358
2009 Huang W, Lewis GK, Wang L. 222 Antibody 2G12 recognizes a glycopeptide epitope on HIV-1 gp120 envelope glycoprotein Journal of Acquired Immune Deficiency Syndromes. 51: 1. DOI: 10.1097/01.Qai.0000351178.71714.B5  0.394
2008 Huang W, Ochiai H, Zhang X, Wang LX. Introducing N-glycans into natural products through a chemoenzymatic approach. Carbohydrate Research. 343: 2903-13. PMID 18805520 DOI: 10.1016/J.Carres.2008.08.033  0.432
2008 Ochiai H, Huang W, Wang LX. Expeditious chemoenzymatic synthesis of homogeneous N-glycoproteins carrying defined oligosaccharide ligands. Journal of the American Chemical Society. 130: 13790-803. PMID 18803385 DOI: 10.1021/Ja805044X  0.443
2008 Li C, Huang W, Wang LX. Chemoenzymatic synthesis of N-linked neoglycoproteins through a chitinase-catalyzed transglycosylation. Bioorganic & Medicinal Chemistry. 16: 8366-72. PMID 18783954 DOI: 10.1016/J.Bmc.2008.08.042  0.394
2008 Wei Y, Li C, Huang W, Li B, Strome S, Wang LX. Glycoengineering of human IgG1-Fc through combined yeast expression and in vitro chemoenzymatic glycosylation Biochemistry. 47: 10294-10304. PMID 18771295 DOI: 10.1021/Bi800874Y  0.387
2008 Wang LX. Chemoenzymatic synthesis of glycopeptides and glycoproteins through endoglycosidase-catalyzed transglycosylation. Carbohydrate Research. 343: 1509-22. PMID 18405887 DOI: 10.1016/J.Carres.2008.03.025  0.411
2008 Li B, Takegawa K, Suzuki T, Yamamoto K, Wang LX. Synthesis and inhibitory activity of oligosaccharide thiazolines as a class of mechanism-based inhibitors for endo-beta-N-acetylglucosaminidases. Bioorganic & Medicinal Chemistry. 16: 4670-5. PMID 18304822 DOI: 10.1016/J.Bmc.2008.02.032  0.349
2008 Umekawa M, Huang W, Li B, Fujita K, Ashida H, Wang LX, Yamamoto K. Mutants of Mucor hiemalis endo-beta-N-acetylglucosaminidase show enhanced transglycosylation and glycosynthase-like activities. The Journal of Biological Chemistry. 283: 4469-79. PMID 18096701 DOI: 10.1074/Jbc.M707137200  0.401
2007 Wang J, Li H, Zou G, Wang LX. Novel template-assembled oligosaccharide clusters as epitope mimics for HIV-neutralizing antibody 2G12. Design, synthesis, and antibody binding study. Organic & Biomolecular Chemistry. 5: 1529-40. PMID 17571181 DOI: 10.1039/B702961F  0.375
2007 Li H, Guan Y, Szczepanska A, Moreno-Vargas AJ, Carmona AT, Robina I, Lewis GK, Wang LX. Synthesis and anti-HIV activity of trivalent CD4-mimetic miniproteins. Bioorganic & Medicinal Chemistry. 15: 4220-8. PMID 17412600 DOI: 10.1016/J.Bmc.2007.03.064  0.36
2006 Li B, Song H, Hauser S, Wang LX. A highly efficient chemoenzymatic approach toward glycoprotein synthesis. Organic Letters. 8: 3081-4. PMID 16805557 DOI: 10.1021/Ol061056M  0.351
2006 Ni J, Song H, Wang Y, Stamatos NM, Wang LX. Toward a carbohydrate-based HIV-1 vaccine: synthesis and immunological studies of oligomannose-containing glycoconjugates. Bioconjugate Chemistry. 17: 493-500. PMID 16536482 DOI: 10.1021/Bc0502816  0.448
2006 Wang L, Li B, Li H, Wang J. Toward a glycopeptide-based HIV-1 vaccine Retrovirology. 3. DOI: 10.1186/1742-4690-3-S1-S75  0.43
2005 Li H, Li B, Song H, Breydo L, Baskakov IV, Wang LX. Chemoenzymatic synthesis of HIV-1 V3 glycopeptides carrying two N-glycans and effects of glycosylation on the peptide domain. The Journal of Organic Chemistry. 70: 9990-6. PMID 16292832 DOI: 10.1021/Jo051729Z  0.369
2005 Li B, Zeng Y, Hauser S, Song H, Wang LX. Highly efficient endoglycosidase-catalyzed synthesis of glycopeptides using oligosaccharide oxazolines as donor substrates. Journal of the American Chemical Society. 127: 9692-3. PMID 15998066 DOI: 10.1021/Ja051715A  0.364
2005 Stamatos NM, Liang F, Nan X, Landry K, Cross AS, Wang LX, Pshezhetsky AV. Differential expression of endogenous sialidases of human monocytes during cellular differentiation into macrophages. The Febs Journal. 272: 2545-56. PMID 15885103 DOI: 10.1111/J.1742-4658.2005.04679.X  0.313
2005 Wang LX, Song H, Liu S, Lu H, Jiang S, Ni J, Li H. Chemoenzymatic synthesis of HIV-1 gp41 glycopeptides: effects of glycosylation on the anti-HIV activity and alpha-helix bundle-forming ability of peptide C34. Chembiochem : a European Journal of Chemical Biology. 6: 1068-74. PMID 15883971 DOI: 10.1002/Cbic.200400440  0.364
2005 Wang J, Le N, Heredia A, Song H, Redfield R, Wang LX. Modification and structure-activity relationship of a small molecule HIV-1 inhibitor targeting the viral envelope glycoprotein gp120. Organic & Biomolecular Chemistry. 3: 1781-6. PMID 15858664 DOI: 10.1039/B415159C  0.323
2005 Hauser S, Song H, Li H, Wang LX. A novel fluorescence-based assay for the transglycosylation activity of endo-beta-N-acetylglucosaminidases. Biochemical and Biophysical Research Communications. 328: 580-5. PMID 15694387 DOI: 10.1016/J.Bbrc.2005.01.012  0.353
2005 Li H, Singh S, Zeng Y, Song H, Wang LX. Chemoenzymatic synthesis of CD52 glycoproteins carrying native N-glycans. Bioorganic & Medicinal Chemistry Letters. 15: 895-8. PMID 15686882 DOI: 10.1016/J.Bmcl.2004.12.066  0.337
2005 Wang L, Li B, Li B, Hauser S, Song H. Retrovirology. 2: P104. DOI: 10.1186/1742-4690-2-S1-P104  0.463
2004 Wang LX, Heredia A, Song H, Zhang Z, Yu B, Davis C, Redfield R. Resveratrol glucuronides as the metabolites of resveratrol in humans: characterization, synthesis, and anti-HIV activity. Journal of Pharmaceutical Sciences. 93: 2448-57. PMID 15349955 DOI: 10.1002/Jps.20156  0.348
2004 Li H, Song H, Heredia A, Le N, Redfield R, Lewis GK, Wang LX. Synthetic bivalent CD4-mimetic miniproteins show enhanced anti-HIV activity over the monovalent miniprotein. Bioconjugate Chemistry. 15: 783-9. PMID 15264865 DOI: 10.1021/Bc049960R  0.361
2004 Ni J, Powell R, Baskakov IV, DeVico A, Lewis GK, Wang LX. Synthesis, conformation, and immunogenicity of monosaccharide-centered multivalent HIV-1 gp41 peptides containing the sequence of DP178. Bioorganic & Medicinal Chemistry. 12: 3141-8. PMID 15158782 DOI: 10.1016/J.Bmc.2004.04.008  0.323
2004 Wang LX, Ni J, Singh S, Li H. Binding of high-mannose-type oligosaccharides and synthetic oligomannose clusters to human antibody 2G12: implications for HIV-1 vaccine design. Chemistry & Biology. 11: 127-34. PMID 15113002 DOI: 10.1016/J.Chembiol.2003.12.020  0.364
2004 Naicker KP, Li H, Heredia A, Song H, Wang LX. Design and synthesis of alpha Gal-conjugated peptide T20 as novel antiviral agent for HIV-immunotargeting. Organic & Biomolecular Chemistry. 2: 660-4. PMID 14985805 DOI: 10.1039/B313844E  0.415
2004 Naicker KP, Jiang S, Lu H, Ni J, Boyer-Chatenet L, Wang LX, Debnath AK. Synthesis and anti-HIV-1 activity of 4-[4-(4,6-bisphenylamino-triazin-2-ylamino)-5-methoxy-2-methylphenylazo]-5-hydroxynaphthalene-2,7-disulfonic acid and its derivatives. Bioorganic & Medicinal Chemistry. 12: 1215-20. PMID 14980633 DOI: 10.1016/J.Bmc.2003.11.006  0.342
2004 Li H, Wang LX. Design and synthesis of a template-assembled oligomannose cluster as an epitope mimic for human HIV-neutralizing antibody 2G12. Organic & Biomolecular Chemistry. 2: 483-8. PMID 14770226 DOI: 10.1039/B314565D  0.418
2004 Locke D, Bevans CG, Wang LX, Zhang Y, Harris AL, Lee YC. Neutral, acidic, and basic derivatives of anthranilamide that confer different formal charge to reducing oligosaccharides. Carbohydrate Research. 339: 221-31. PMID 14698880 DOI: 10.1016/J.Carres.2003.10.020  0.445
2003 Locke D, Wang LX, Bevans CG, Lee YC, Harris AL. Open pore block of connexin26 and connexin32 hemichannels by neutral, acidic and basic glycoconjugates. Cell Communication & Adhesion. 10: 239-44. PMID 14681023 DOI: 10.1080/Cac.10.4-6.239.244  0.462
2003 Wang LX. Bioorganic approaches towards HIV vaccine design. Current Pharmaceutical Design. 9: 1771-87. PMID 12871196 DOI: 10.2174/1381612033454432  0.35
2003 Singh S, Ni J, Wang LX. Chemoenzymatic synthesis of high-mannose type HIV-1 gp120 glycopeptides. Bioorganic & Medicinal Chemistry Letters. 13: 327-30. PMID 12565922 DOI: 10.1016/S0960-894X(02)01025-9  0.367
2003 Ni J, Singh S, Wang LX. Synthesis of maleimide-activated carbohydrates as chemoselective tags for site-specific glycosylation of peptides and proteins. Bioconjugate Chemistry. 14: 232-8. PMID 12526713 DOI: 10.1021/Bc025617F  0.39
2003 Wang LX, Ni J, Singh S. Carbohydrate-centered maleimide cluster as a new type of templates for multivalent peptide assembling. synthesis of multivalent HIV-1 gp41 peptides. Bioorganic & Medicinal Chemistry. 11: 159-66. PMID 12467718 DOI: 10.1016/S0968-0896(02)00339-5  0.33
2002 Southwick AM, Wang LX, Long SR, Lee YC. Activity of Sinorhizobium meliloti NodAB and NodH enzymes on thiochitooligosaccharides. Journal of Bacteriology. 184: 4039-43. PMID 12081977 DOI: 10.1128/Jb.184.14.4039-4043.2002  0.493
2000 Kasuya MC, Wang LX, Lee YC, Mitsuki M, Nakajima H, Miura Y, Sato T, Hatanaka K, Yamagata S, Yamagata T. Azido glycoside primer: a versatile building block for the biocombinatorial synthesis of glycosphingolipid analogues. Carbohydrate Research. 329: 755-63. PMID 11125817 DOI: 10.1016/S0008-6215(00)00238-X  0.407
2000 Keyhani NO, Wang LX, Lee YC, Roseman S. The chitin disaccharide, N,N'-diacetylchitobiose, is catabolized by Escherichia coli and is transported/phosphorylated by the phosphoenolpyruvate:glycose phosphotransferase system. The Journal of Biological Chemistry. 275: 33084-90. PMID 10913117 DOI: 10.1074/Jbc.M001043200  0.522
1998 Kiang J, Wang LX, Tang M, Szu SC, Lee YC. Simultaneous determination of glucosamine and glucosamine 4-phosphate in Lipid A with high-performance anion-exchange chromatography (HPAEC). Carbohydrate Research. 312: 73-6. PMID 9836452 DOI: 10.1016/S0008-6215(98)00226-2  0.418
1998 Wang LX, Pavlova NV, Yang M, Li SC, Li YT, Lee YC. Synthesis of aryl 3'-sulfo-beta-lactosides as fluorogenic and chromogenic substrates for ceramide glycanases. Carbohydrate Research. 306: 341-8. PMID 9648244 DOI: 10.1016/S0008-6215(97)10082-9  0.479
1997 Wang LX, Keyhani NO, Roseman S, Lee YC. 4-Methylumbelliferyl glycosides of N-acetyl 4-thiochito-oligosaccharides as fluorogenic substrates for chitodextrinase from Vibrio furnissii. Glycobiology. 7: 855-60. PMID 9376688 DOI: 10.1093/Glycob/7.6.855  0.535
1997 Li YT, Wang LX, Pavlova NV, Li SC, Lee YC. alpha-KDOase activity in oyster and synthesis of alpha- and beta-4-methylumbelliferyl ketosides of 3-deoxy-D-manno-octulosonic acid. The Journal of Biological Chemistry. 272: 26419-24. PMID 9334217  0.354
1997 Kiang J, Szu SC, Wang LX, Tang M, Lee YC. Determination of 2-keto-3-deoxyoctulosonic acid (KDO) with high-performance anion-exchange chromatography (HPAEC): survey of stability of KDO and optimal hydrolytic conditions. Analytical Biochemistry. 245: 97-101. PMID 9025974 DOI: 10.1006/Abio.1996.9951  0.42
1997 Wang L, Tang M, Suzuki T, Kitajima K, Inoue Y, Inoue S, Fan J, Lee YC. Combined Chemical and Enzymatic Synthesis of aC-Glycopeptide and Its Inhibitory Activity toward Glycoamidases Journal of the American Chemical Society. 119: 11137-11146. DOI: 10.1021/Ja9712027  0.388
1996 Keyhani NO, Wang LX, Lee YC, Roseman S. The chitin catabolic cascade in the marine bacterium Vibrio furnissii. Characterization of an N,N'-diacetyl-chitobiose transport system. The Journal of Biological Chemistry. 271: 33409-13. PMID 8969203 DOI: 10.1074/Jbc.271.52.33409  0.516
1996 Wang LX, Pavlova NV, Li SC, Li YT, Lee YC. A fluorometric assay of ceramide glycanase with 4-methylumbelliferyl beta-D-lactoside derivatives. Glycoconjugate Journal. 13: 359-65. PMID 8781966 DOI: 10.1007/Bf00731468  0.456
1991 Wang L, Sakairi N, Kuzuhara H. Peracetylated laminaribiose: preparation by specific degradation of curdlan and its chemical conversion into N-acetylhyalobiuronic acid Carbohydrate Research. 219: 133-148. PMID 1804530 DOI: 10.1016/0008-6215(91)89048-K  0.333
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