| Year |
Citation |
Score |
| 2024 |
Chen C, Kumbhar R, Wang H, Yang X, Gadhave K, Rastegar C, Kimura Y, Behensky A, Kotha S, Kuo G, Katakam S, Jeong D, Wang L, Wang A, Chen R, ... ... Wong PC, et al. Lymphocyte-Activation Gene 3 Facilitates Pathological Tau Neuron-to-Neuron Transmission. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). e2303775. PMID 38327094 DOI: 10.1002/advs.202303775 |
0.307 |
|
| 2023 |
Chang K, Ling JP, Redding-Ochoa J, An Y, Li L, Dean SA, Blanchard TG, Pylyukh T, Barrett A, Irwin KE, Moghekar A, Resnick SM, Wong PC, Troncoso JC. Loss of TDP-43 splicing repression occurs early in the aging population and is associated with Alzheimer's disease neuropathologic changes and cognitive decline. Acta Neuropathologica. 147: 4. PMID 38133681 DOI: 10.1007/s00401-023-02653-2 |
0.581 |
|
| 2023 |
Chen C, Kumbhar R, Wang H, Yang X, Gadhave K, Rastegar C, Kimura Y, Behensky A, Katakam S, Jeong D, Wang L, Wang A, Chen R, Zhang S, Jin L, ... ... Wong PC, et al. Pathological Tau transmission initiated by binding lymphocyte-activation gene 3. Biorxiv : the Preprint Server For Biology. PMID 37293032 DOI: 10.1101/2023.05.16.541015 |
0.308 |
|
| 2023 |
Carmen-Orozco RP, Tsao W, Ye Y, Sinha IR, Chang K, Trinh V, Chung W, Bowden K, Troncoso JC, Blackshaw S, Hayes LR, Sun S, Wong PC, Ling JP. Elevated nuclear TDP-43 induces constitutive exon skipping. Biorxiv : the Preprint Server For Biology. PMID 37215013 DOI: 10.1101/2023.05.11.540291 |
0.694 |
|
| 2023 |
Irwin KE, Jasin P, Braunstein KE, Sinha I, Bowden KD, Moghekar A, Oh ES, Raitcheva D, Bartlett D, Berry JD, Traynor B, Ling JP, Wong PC. A fluid biomarker reveals loss of TDP-43 splicing repression in pre-symptomatic ALS. Biorxiv : the Preprint Server For Biology. PMID 36789434 DOI: 10.1101/2023.01.23.525202 |
0.581 |
|
| 2022 |
Kim DW, Tu KJ, Wei A, Lau AJ, Gonzalez-Gil A, Cao T, Braunstein K, Ling JP, Troncoso JC, Wong PC, Blackshaw S, Schnaar RL, Li T. Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes. Molecular Neurodegeneration. 17: 83. PMID 36536457 DOI: 10.1186/s13024-022-00589-x |
0.703 |
|
| 2022 |
Britson KA, Ling JP, Braunstein KE, Montagne JM, Kastenschmidt JM, Wilson A, Ikenaga C, Tsao W, Pinal-Fernandez I, Russell KA, Reed N, Mozaffar T, Wagner KR, Ostrow LW, Corse AM, ... ... Wong PC, et al. Loss of TDP-43 function and rimmed vacuoles persist after T cell depletion in a xenograft model of sporadic inclusion body myositis. Science Translational Medicine. 14: eabi9196. PMID 35044790 DOI: 10.1126/scitranslmed.abi9196 |
0.566 |
|
| 2022 |
Islam S, Sun Y, Gao Y, Nakamura T, Noorani AA, Li T, Wong PC, Kimura N, Matsubara E, Kasuga K, Ikeuchi T, Tomita T, Zou K, Michikawa M. Presenilin is essential for ApoE secretion, a novel role of presenilin involved in Alzheimer's disease pathogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 34987110 DOI: 10.1523/JNEUROSCI.2039-21.2021 |
0.31 |
|
| 2020 |
Sieverding K, Ulmer J, Bruno C, Satoh T, Tsao W, Freischmidt A, Akira S, Wong PC, Ludolph AC, Danzer KM, Lobsiger CS, Brenner D, Weishaupt JH. Hemizygous deletion of Tbk1 worsens neuromuscular junction pathology in TDP-43 transgenic mice. Experimental Neurology. 113496. PMID 33038415 DOI: 10.1016/j.expneurol.2020.113496 |
0.333 |
|
| 2020 |
Chen L, Wei Z, Chan KW, Li Y, Suchal K, Bi S, Huang J, Xu X, Wong PC, Lu H, van Zijl PC, Li T, Xu J. D-Glucose uptake and clearance in the tauopathy Alzheimer's disease mouse brain detected by on-resonance variable delay multiple pulse MRI. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X20941264. PMID 32669023 DOI: 10.1177/0271678X20941264 |
0.34 |
|
| 2019 |
Donde A, Sun M, Ling JP, Braunstein KE, Pang B, Wen X, Cheng X, Chen L, Wong PC. Splicing repression is a major function of TDP-43 in motor neurons. Acta Neuropathologica. PMID 31332509 DOI: 10.1007/S00401-019-02042-8 |
0.644 |
|
| 2019 |
Donde A, Sun M, Jeong YH, Wen X, Ling J, Lin S, Braunstein K, Nie S, Wang S, Chen L, Wong PC. Upregulation of ATG7 Attenuates Motor Neuron Dysfunction Associated with Depletion of TARDBP/TDP-43. Autophagy. PMID 31242080 DOI: 10.1080/15548627.2019.1635379 |
0.737 |
|
| 2018 |
Chen L, Wei Z, Chan K, Cai S, Liu G, Lu H, Wong PC, van Zijl PCM, Li T, Xu J. Protein aggregation linked to Alzheimer's disease revealed by saturation transfer MRI. Neuroimage. PMID 30553917 DOI: 10.1016/J.Neuroimage.2018.12.018 |
0.324 |
|
| 2017 |
Wiesner D, Tar L, Linkus B, Chandrasekar A, Heuvel FO, Dupuis L, Tsao W, Wong PC, Ludolph A, Roselli F. Reversible induction of TDP-43 granules in cortical neurons after traumatic injury. Experimental Neurology. PMID 28941811 DOI: 10.1016/J.Expneurol.2017.09.011 |
0.394 |
|
| 2017 |
Sun M, Bell W, LaClair KD, Ling JP, Han H, Kageyama Y, Pletnikova O, Troncoso JC, Wong PC, Chen LL. Cryptic exon incorporation occurs in Alzheimer's brain lacking TDP-43 inclusion but exhibiting nuclear clearance of TDP-43. Acta Neuropathologica. PMID 28332094 DOI: 10.1007/S00401-017-1701-2 |
0.638 |
|
| 2017 |
Jeong YH, Ling JP, Lin SZ, Donde AN, Braunstein KE, Majounie E, Traynor BJ, LaClair KD, Lloyd TE, Wong PC. Tdp-43 cryptic exons are highly variable between cell types. Molecular Neurodegeneration. 12: 13. PMID 28153034 DOI: 10.1186/S13024-016-0144-X |
0.713 |
|
| 2016 |
Bedont JL, LeGates TA, Buhr E, Bathini A, Ling JP, Bell B, Wu MN, Wong PC, Van Gelder RN, Mongrain V, Hattar S, Blackshaw S. An LHX1-Regulated Transcriptional Network Controls Sleep/Wake Coupling and Thermal Resistance of the Central Circadian Clockworks. Current Biology : Cb. PMID 28017605 DOI: 10.1016/J.Cub.2016.11.008 |
0.659 |
|
| 2016 |
Le NT, Chang L, Kovlyagina I, Georgiou P, Safren N, Braunstein KE, Kvarta MD, Van Dyke AM, LeGates TA, Philips T, Morrison BM, Thompson SM, Puche AC, Gould TD, Rothstein JD, ... Wong PC, et al. Motor neuron disease, TDP-43 pathology, and memory deficits in mice expressing ALS-FTD-linked UBQLN2 mutations. Proceedings of the National Academy of Sciences of the United States of America. PMID 27834214 DOI: 10.1073/Pnas.1608432113 |
0.465 |
|
| 2016 |
LaClair KD, Donde A, Ling JP, Jeong YH, Chhabra R, Martin LJ, Wong PC. Depletion of TDP-43 decreases fibril and plaque β-amyloid and exacerbates neurodegeneration in an Alzheimer's mouse model. Acta Neuropathologica. PMID 27785573 DOI: 10.1007/S00401-016-1637-Y |
0.665 |
|
| 2016 |
Ling JP, Chhabra R, Merran JD, Schaughency PM, Wheelan SJ, Corden JL, Wong PC. PTBP1 and PTBP2 Repress Nonconserved Cryptic Exons. Cell Reports. 17: 104-13. PMID 27681424 DOI: 10.1016/J.Celrep.2016.08.071 |
0.597 |
|
| 2016 |
Li T, Braunstein KE, Zhang J, Lau A, Sibener L, Deeble C, Wong PC. The neuritic plaque facilitates pathological conversion of tau in an Alzheimer's disease mouse model. Nature Communications. 7: 12082. PMID 27373369 DOI: 10.1038/Ncomms12082 |
0.404 |
|
| 2016 |
El Oussini H, Bayer H, Scekic-Zahirovic J, Vercruysse P, Sinniger J, Dirrig-Grosch S, Dieterlé S, Echaniz-Laguna A, Larmet Y, Müller K, Weishaupt JH, Thal DR, van Rheenen W, van Eijk K, Lawson R, ... ... Wong PC, et al. Serotonin 2B receptor slows disease progression and prevents degeneration of spinal cord mononuclear phagocytes in amyotrophic lateral sclerosis. Acta Neuropathologica. PMID 26744351 DOI: 10.1007/S00401-016-1534-4 |
0.352 |
|
| 2016 |
Melnikova T, Shyam R, Porter S, LaClair K, Park D, Moghekar A, Farah M, Wong PC, Savonenko A. G-Secretase Modulator Enhances The Ab-Lowering Effect Of Bace1 Inhibitor In Mouse Models Of Alzheimer’S Disease Alzheimers & Dementia. 12. DOI: 10.1016/J.Jalz.2016.06.719 |
0.308 |
|
| 2015 |
Megill A, Tran T, Eldred K, Lee NJ, Wong PC, Hoe HS, Kirkwood A, Lee HK. Defective Age-Dependent Metaplasticity in a Mouse Model of Alzheimer's Disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 11346-57. PMID 26269641 DOI: 10.1523/Jneurosci.5289-14.2015 |
0.628 |
|
| 2015 |
Ling JP, Pletnikova O, Troncoso JC, Wong PC. NEURODEGENERATION. TDP-43 repression of nonconserved cryptic exons is compromised in ALS-FTD. Science (New York, N.Y.). 349: 650-5. PMID 26250685 DOI: 10.1126/Science.Aab0983 |
0.616 |
|
| 2015 |
Heiman-Patterson TD, Blankenhorn EP, Sher RB, Jiang J, Welsh P, Dixon MC, Jeffrey JI, Wong P, Cox GA, Alexander GM. Genetic background effects on disease onset and lifespan of the mutant dynactin p150Glued mouse model of motor neuron disease. Plos One. 10: e0117848. PMID 25763819 DOI: 10.1371/Journal.Pone.0117848 |
0.328 |
|
| 2015 |
Wiesner D, Sinniger J, Henriques A, Dieterlé S, Müller HP, Rasche V, Ferger B, Dirrig-Grosch S, Soylu-Kucharz R, Petersén A, Walther P, Linkus B, Kassubek J, Wong PC, Ludolph AC, et al. Low dietary protein content alleviates motor symptoms in mice with mutant dynactin/dynein-mediated neurodegeneration. Human Molecular Genetics. 24: 2228-40. PMID 25552654 DOI: 10.1093/Hmg/Ddu741 |
0.379 |
|
| 2015 |
Ling JP, Pletnikova O, Troncoso JC, Wong PC. TDP-43 repression of nonconserved cryptic exons is compromised in ALS-FTD Science. 349: 650-655. DOI: 10.1126/science.aab0983 |
0.576 |
|
| 2014 |
Vassar R, Kuhn PH, Haass C, Kennedy ME, Rajendran L, Wong PC, Lichtenthaler SF. Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects. Journal of Neurochemistry. 130: 4-28. PMID 24646365 DOI: 10.1111/Jnc.12715 |
0.421 |
|
| 2014 |
Wang H, Megill A, Wong PC, Kirkwood A, Lee HK. Postsynaptic target specific synaptic dysfunctions in the CA3 area of BACE1 knockout mice. Plos One. 9: e92279. PMID 24637500 DOI: 10.1371/Journal.Pone.0092279 |
0.633 |
|
| 2014 |
Savonenko AV, Melnikova T, Li T, Price DL, Wong PC. Alzheimer Disease Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders. 321-338. DOI: 10.1016/B978-0-12-398270-4.00021-5 |
0.566 |
|
| 2013 |
Haidet-Phillips AM, Gross SK, Williams T, Tuteja A, Sherman A, Ko M, Jeong YH, Wong PC, Maragakis NJ. Altered astrocytic expression of TDP-43 does not influence motor neuron survival. Experimental Neurology. 250: 250-9. PMID 24120466 DOI: 10.1016/J.Expneurol.2013.10.004 |
0.373 |
|
| 2013 |
LaClair KD, Manaye KF, Lee DL, Allard JS, Savonenko AV, Troncoso JC, Wong PC. Treatment with bexarotene, a compound that increases apolipoprotein-E, provides no cognitive benefit in mutant APP/PS1 mice. Molecular Neurodegeneration. 8: 18. PMID 23764200 DOI: 10.1186/1750-1326-8-18 |
0.395 |
|
| 2013 |
Stockmann M, Meyer-Ohlendorf M, Achberger K, Putz S, Demestre M, Yin H, Hendrich C, Linta L, Heinrich J, Brunner C, Proepper C, Kuh GF, Baumann B, Langer T, Schwalenstöcker B, ... ... Wong PC, et al. The dynactin p150 subunit: cell biology studies of sequence changes found in ALS/MND and Parkinsonian syndromes. Journal of Neural Transmission (Vienna, Austria : 1996). 120: 785-98. PMID 23143281 DOI: 10.1007/S00702-012-0910-Z |
0.371 |
|
| 2012 |
Tsao W, Jeong YH, Lin S, Ling J, Price DL, Chiang PM, Wong PC. Rodent models of TDP-43: recent advances. Brain Research. 1462: 26-39. PMID 22608070 DOI: 10.1016/J.Brainres.2012.04.031 |
0.776 |
|
| 2012 |
Savonenko AV, Melnikova T, Hiatt A, Li T, Worley PF, Troncoso JC, Wong PC, Price DL. Alzheimer's therapeutics: translation of preclinical science to clinical drug development. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 261-77. PMID 21937983 DOI: 10.1038/Npp.2011.211 |
0.508 |
|
| 2012 |
Chiang PM, Fortna RR, Price DL, Li T, Wong PC. Specific domains in anterior pharynx-defective 1 determine its intramembrane interactions with nicastrin and presenilin. Neurobiology of Aging. 33: 277-85. PMID 20382452 DOI: 10.1016/J.Neurobiolaging.2009.12.028 |
0.576 |
|
| 2012 |
Price DL, Savonenko AV, Li T, Wong PC. Alzheimer’s disease Translational Neuroscience: Applications in Psychiatry, Neurology, and Neurodevelopmental Disorders. 149-167. DOI: 10.1017/CBO9780511980053.009 |
0.533 |
|
| 2012 |
Wong PC, Savonenko A, Li T, Price DL. Neurobiology of Alzheimer's Disease Basic Neurochemistry. 815-828. DOI: 10.1016/B978-0-12-374947-5.00046-8 |
0.559 |
|
| 2012 |
Wong PC, Chiang PM, Martin LJ, Koliatsos V, Price DL. Motor Neuron Diseases Basic Neurochemistry. 801-814. DOI: 10.1016/B978-0-12-374947-5.00045-6 |
0.564 |
|
| 2011 |
Li T, Li YM, Ahn K, Price DL, Sisodia SS, Wong PC. Increased expression of PS1 is sufficient to elevate the level and activity of γ-secretase in vivo. Plos One. 6: e28179. PMID 22140537 DOI: 10.1371/Journal.Pone.0028179 |
0.634 |
|
| 2011 |
Wu J, Petralia RS, Kurushima H, Patel H, Jung MY, Volk L, Chowdhury S, Shepherd JD, Dehoff M, Li Y, Kuhl D, Huganir RL, Price DL, Scannevin R, Troncoso JC, ... Wong PC, et al. Arc/Arg3.1 regulates an endosomal pathway essential for activity-dependent β-amyloid generation. Cell. 147: 615-28. PMID 22036569 DOI: 10.1016/J.Cell.2011.09.036 |
0.587 |
|
| 2011 |
Farah MH, Pan BH, Hoffman PN, Ferraris D, Tsukamoto T, Nguyen T, Wong PC, Price DL, Slusher BS, Griffin JW. Reduced BACE1 activity enhances clearance of myelin debris and regeneration of axons in the injured peripheral nervous system. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 5744-54. PMID 21490216 DOI: 10.1523/Jneurosci.6810-10.2011 |
0.562 |
|
| 2011 |
Tomita T, Wong PC. Selectivity to amyloid-β precursor protein cleavage provides hope against Alzheimer's. Alzheimer's Research & Therapy. 3: 7. PMID 21418547 DOI: 10.1186/Alzrt66 |
0.379 |
|
| 2010 |
Wang H, Song L, Lee A, Laird F, Wong PC, Lee HK. Mossy fiber long-term potentiation deficits in BACE1 knock-outs can be rescued by activation of alpha7 nicotinic acetylcholine receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 13808-13. PMID 20943921 DOI: 10.1523/Jneurosci.1070-10.2010 |
0.656 |
|
| 2010 |
Shan X, Chiang PM, Price DL, Wong PC. Altered distributions of Gemini of coiled bodies and mitochondria in motor neurons of TDP-43 transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 107: 16325-30. PMID 20736350 DOI: 10.1073/pnas.1003459107 |
0.584 |
|
| 2010 |
Chiang PM, Ling J, Jeong YH, Price DL, Aja SM, Wong PC. Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism. Proceedings of the National Academy of Sciences of the United States of America. 107: 16320-4. PMID 20660762 DOI: 10.1073/Pnas.1002176107 |
0.675 |
|
| 2010 |
Chow VW, Savonenko AV, Melnikova T, Kim H, Price DL, Li T, Wong PC. Modeling an anti-amyloid combination therapy for Alzheimer's disease. Science Translational Medicine. 2: 13ra1. PMID 20371462 DOI: 10.1126/Scitranslmed.3000337 |
0.638 |
|
| 2010 |
Hoffman PN, Wong PC, Griffin JW, Price DL. Axonal Transport Disorders Encyclopedia of Neuroscience. 1205-1208. DOI: 10.1016/B978-008045046-9.00553-2 |
0.455 |
|
| 2010 |
Price DL, Savonenko AV, Albert M, Troncoso JC, Wong PC. Aging of the Brain and Alzheimer's Disease Encyclopedia of Neuroscience. 187-195. DOI: 10.1016/B978-008045046-9.00539-8 |
0.539 |
|
| 2010 |
Price DL, Savonenko AV, Li T, Lee MK, Wong PC. Alzheimer Disease: Protein Misfolding, Model Systems, and Experimental Therapeutics Protein Misfolding Diseases: Current and Emerging Principles and Therapies. 231-258. DOI: 10.1002/9780470572702.ch12 |
0.555 |
|
| 2009 |
Hayashi I, Takatori S, Urano Y, Iwanari H, Isoo N, Osawa S, Fukuda MA, Kodama T, Hamakubo T, Li T, Wong PC, Tomita T, Iwatsubo T. Single chain variable fragment against nicastrin inhibits the gamma-secretase activity. The Journal of Biological Chemistry. 284: 27838-47. PMID 19684016 DOI: 10.1074/Jbc.M109.055061 |
0.317 |
|
| 2009 |
Pardossi-Piquard R, Yang SP, Kanemoto S, Gu Y, Chen F, Böhm C, Sevalle J, Li T, Wong PC, Checler F, Schmitt-Ulms G, St George-Hyslop P, Fraser PE. APH1 polar transmembrane residues regulate the assembly and activity of presenilin complexes. The Journal of Biological Chemistry. 284: 16298-307. PMID 19369254 DOI: 10.1074/Jbc.M109.000067 |
0.304 |
|
| 2008 |
Wong PC. Translational control of BACE1 may go awry in Alzheimer's disease. Neuron. 60: 941-3. PMID 19109900 DOI: 10.1016/J.Neuron.2008.12.010 |
0.405 |
|
| 2008 |
Wang H, Song L, Laird F, Wong PC, Lee HK. BACE1 knock-outs display deficits in activity-dependent potentiation of synaptic transmission at mossy fiber to CA3 synapses in the hippocampus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 8677-81. PMID 18753368 DOI: 10.1523/Jneurosci.2440-08.2008 |
0.654 |
|
| 2008 |
Savonenko AV, Melnikova T, Laird FM, Stewart KA, Price DL, Wong PC. Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice. Proceedings of the National Academy of Sciences of the United States of America. 105: 5585-90. PMID 18385378 DOI: 10.1073/Pnas.0710373105 |
0.608 |
|
| 2008 |
Laird FM, Farah MH, Ackerley S, Hoke A, Maragakis N, Rothstein JD, Griffin J, Price DL, Martin LJ, Wong PC. Motor neuron disease occurring in a mutant dynactin mouse model is characterized by defects in vesicular trafficking. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 1997-2005. PMID 18305234 DOI: 10.1523/Jneurosci.4231-07.2008 |
0.656 |
|
| 2008 |
Chandran JS, Lin X, Zapata A, Höke A, Shimoji M, Moore SO, Galloway MP, Laird FM, Wong PC, Price DL, Bailey KR, Crawley JN, Shippenberg T, Cai H. Progressive behavioral deficits in DJ-1-deficient mice are associated with normal nigrostriatal function. Neurobiology of Disease. 29: 505-14. PMID 18187333 DOI: 10.1016/J.Nbd.2007.11.011 |
0.779 |
|
| 2008 |
Wong PC, Price DL, Bertram L, Tanzi RE. 14 Alzheimer’s Disease: Genetics, Pathogenesis, Models, and Experimental Therapeutics Cold Spring Harbor Monograph Archive. 51: 371-407. DOI: 10.1101/087969824.51.371 |
0.591 |
|
| 2007 |
Li T, Wen H, Brayton C, Laird FM, Ma G, Peng S, Placanica L, Wu TC, Crain BJ, Price DL, Eberhart CG, Wong PC. Moderate reduction of gamma-secretase attenuates amyloid burden and limits mechanism-based liabilities. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 10849-59. PMID 17913918 DOI: 10.1523/Jneurosci.2152-07.2007 |
0.62 |
|
| 2007 |
Li T, Wen H, Brayton C, Das P, Smithson LA, Fauq A, Fan X, Crain BJ, Price DL, Golde TE, Eberhart CG, Wong PC. Epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of gamma-secretase. The Journal of Biological Chemistry. 282: 32264-73. PMID 17827153 DOI: 10.1074/Jbc.M703649200 |
0.523 |
|
| 2007 |
Choi SH, Leight SN, Lee VM, Li T, Wong PC, Johnson JA, Saraiva MJ, Sisodia SS. Accelerated Abeta deposition in APPswe/PS1deltaE9 mice with hemizygous deletions of TTR (transthyretin). The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 7006-10. PMID 17596449 DOI: 10.1523/Jneurosci.1919-07.2007 |
0.384 |
|
| 2007 |
Laird FM, Farah MH, Lee HK, Savonenko AV, Price DL, Wong PC. β-secretase: Physiological role and target validation Alzheimer's Disease: Advances in Genetics, Molecular and Cellular Biology. 59-76. DOI: 10.1007/978-0-387-35135-3_4 |
0.469 |
|
| 2006 |
Lai C, Xie C, McCormack SG, Chiang HC, Michalak MK, Lin X, Chandran J, Shim H, Shimoji M, Cookson MR, Huganir RL, Rothstein JD, Price DL, Wong PC, Martin LJ, et al. Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 11798-806. PMID 17093100 DOI: 10.1523/Jneurosci.2084-06.2006 |
0.786 |
|
| 2006 |
Nishitomi K, Sakaguchi G, Horikoshi Y, Gray AJ, Maeda M, Hirata-Fukae C, Becker AG, Hosono M, Sakaguchi I, Minami SS, Nakajima Y, Li HF, Takeyama C, Kihara T, Ota A, ... Wong PC, et al. BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild-type mice. Journal of Neurochemistry. 99: 1555-63. PMID 17083447 DOI: 10.1111/J.1471-4159.2006.04178.X |
0.402 |
|
| 2006 |
Horikoshi Y, Hirata C, Gray AJ, Maeda M, Wong PC, Aisen PS, Kinoshita N, Matsuoka Y. P4-297: Development of full-length mouse amyloid beta ELISA and determination of endogenous Abeta level in BACE1 knockout mice Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.2036 |
0.355 |
|
| 2005 |
Wong PC. Alzheimer disease: therapeutic targets for clinical trials. Retina (Philadelphia, Pa.). 25: S80-S81. PMID 16374352 DOI: 10.1097/00006982-200512001-00038 |
0.309 |
|
| 2005 |
Laird FM, Cai H, Savonenko AV, Farah MH, He K, Melnikova T, Wen H, Chiang HC, Xu G, Koliatsos VE, Borchelt DR, Price DL, Lee HK, Wong PC. BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 11693-709. PMID 16354928 DOI: 10.1523/Jneurosci.2766-05.2005 |
0.775 |
|
| 2005 |
Cai H, Lin X, Xie C, Laird FM, Lai C, Wen H, Chiang HC, Shim H, Farah MH, Hoke A, Price DL, Wong PC. Loss of ALS2 function is insufficient to trigger motor neuron degeneration in knock-out mice but predisposes neurons to oxidative stress. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 7567-74. PMID 16107644 DOI: 10.1523/Jneurosci.1645-05.2005 |
0.687 |
|
| 2005 |
Lazarov O, Morfini GA, Lee EB, Farah MH, Szodorai A, DeBoer SR, Koliatsos VE, Kins S, Lee VM, Wong PC, Price DL, Brady ST, Sisodia SS. Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 2386-95. PMID 15745965 DOI: 10.1523/Jneurosci.3089-04.2005 |
0.569 |
|
| 2005 |
Zhang YW, Luo WJ, Wang H, Lin P, Vetrivel KS, Liao F, Li F, Wong PC, Farquhar MG, Thinakaran G, Xu H. Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components. The Journal of Biological Chemistry. 280: 17020-6. PMID 15711015 DOI: 10.1074/Jbc.M409467200 |
0.337 |
|
| 2005 |
Ma G, Li T, Price DL, Wong PC. APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 192-8. PMID 15634781 DOI: 10.1523/Jneurosci.3814-04.2005 |
0.555 |
|
| 2005 |
Price DL, Borchelt DR, Lee MK, Wong PC. Selected genetically engineered models relevant to human neurodegenerative disease Neurodegenerative Diseases: Neurobiology, Pathogenesis and Therapeutics. 176-195. DOI: 10.1017/CBO9780511544873.016 |
0.508 |
|
| 2005 |
Savonenko AV, Laird FM, Troncoso JC, Wong PC, Price DL. Role of Alzheimer's disease models in designing and testing experimental therapeutics Drug Discovery Today: Disease Models. 2: 305-312. DOI: 10.1016/J.Ddmod.2005.11.006 |
0.619 |
|
| 2005 |
Price DL, Borchelt DR, Wong PC. Alzheimer's Disease. Clinical Features, Neuropathological and Biochemical Abnormalities, Genetics, Models, and Experimental Therapeutics From Neuroscience to Neurology. 445-458. DOI: 10.1016/B978-012738903-5/50028-X |
0.547 |
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| 2004 |
Yan XX, Li T, Rominger CM, Prakash SR, Wong PC, Olson RE, Zaczek R, Li YW. Binding sites of gamma-secretase inhibitors in rodent brain: distribution, postnatal development, and effect of deafferentation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 2942-52. PMID 15044533 DOI: 10.1523/Jneurosci.0092-04.2004 |
0.305 |
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| 2004 |
Li R, Lindholm K, Yang LB, Yue X, Citron M, Yan R, Beach T, Sue L, Sabbagh M, Cai H, Wong P, Price D, Shen Y. Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients. Proceedings of the National Academy of Sciences of the United States of America. 101: 3632-7. PMID 14978286 DOI: 10.1073/pnas.0205689101 |
0.671 |
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| 2004 |
Ma G, Li T, Price DL, Wong PC. P4-275 APH-1A is required for presenilin-dependent γ-secretase activity during mouse embryogenesis Neurobiology of Aging. 25: S553-S554. DOI: 10.1016/S0197-4580(04)81833-5 |
0.533 |
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| 2004 |
Cai H, Wen H, Laird FM, Chiang H, Xu G, Borchelt DR, Price DL, Wong PC. P1-222 Deletion of BACE1 prevents age-associated neuropathological abnormalities in mutant APP;PS1 mice Neurobiology of Aging. 25: S159. DOI: 10.1016/S0197-4580(04)80535-9 |
0.678 |
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| 2004 |
Laird FM, Savonenko AV, Melnikova T, Cai H, Borchelt DR, Price DL, Wong PC. P1-179 Age-associated memory deficits occurring in Bace1-deficient mice or APP;PS1 mice are restored in APP;PS1 mice lacking BACE1: a role for APP and BACE1 in cognition Neurobiology of Aging. 25: S146. DOI: 10.1016/S0197-4580(04)80492-5 |
0.679 |
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| 2004 |
Li T, Ma G, Peck J, Wen H, Price DL, Wong PC. O3-05-08 Characterization of γ-secretase complex: analysis of APH-1B deficient mice Neurobiology of Aging. 25: S63. DOI: 10.1016/S0197-4580(04)80213-6 |
0.548 |
|
| 2004 |
Wong PC, Cai H, Laird FM, Savonenko AV, Melnikova T, Price DL, Borchelt DR, Xu G. S1-01-02 A role for APP and BACE1 in cognition Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)80005-8 |
0.638 |
|
| 2003 |
Li T, Ma G, Cai H, Price DL, Wong PC. Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 3272-7. PMID 12716934 |
0.67 |
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| 2003 |
Martin LJ, Price AC, McClendon KB, Al-Abdulla NA, Subramaniam JR, Wong PC, Liu Z. Early events of target deprivation/axotomy-induced neuronal apoptosis in vivo: oxidative stress, DNA damage, p53 phosphorylation and subcellular redistribution of death proteins. Journal of Neurochemistry. 85: 234-47. PMID 12641745 DOI: 10.1046/J.1471-4159.2003.01659.X |
0.308 |
|
| 2003 |
Yang LB, Lindholm K, Yan R, Citron M, Xia W, Yang XL, Beach T, Sue L, Wong P, Price D, Li R, Shen Y. Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease. Nature Medicine. 9: 3-4. PMID 12514700 DOI: 10.1038/nm0103-3 |
0.555 |
|
| 2003 |
Li T, Ma G, Cai H, Price DL, Wong PC. Nicastrin Is Required for Assembly of Presenilin/γ-Secretase Complexes to Mediate Notch Signaling and for Processing and Trafficking of β-Amyloid Precursor Protein in Mammals The Journal of Neuroscience. 23: 3272-3277. DOI: 10.1523/Jneurosci.23-08-03272.2003 |
0.549 |
|
| 2002 |
Wong PC, Cai H, Borchelt DR, Price DL. Genetically engineered mouse models of neurodegenerative diseases. Nature Neuroscience. 5: 633-9. PMID 12085093 DOI: 10.1038/Nn0702-633 |
0.723 |
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| 2002 |
Subramaniam JR, Lyons WE, Liu J, Bartnikas TB, Rothstein J, Price DL, Cleveland DW, Gitlin JD, Wong PC. Mutant SOD1 causes motor neuron disease independent of copper chaperone-mediated copper loading. Nature Neuroscience. 5: 301-7. PMID 11889469 DOI: 10.1038/Nn823 |
0.624 |
|
| 2002 |
Wong PC. Reply to 'Is ALS caused by an altered oxidative activity of mutant superoxide dismutase?' Nature Neuroscience. 5: 919-920. DOI: 10.1038/Nn1002-919B |
0.385 |
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| 2001 |
Wong PC, Cai H, Borchelt DR, Price DL. Genetically engineered models relevant to neurodegenerative disorders: their value for understanding disease mechanisms and designing/testing experimental therapeutics. Journal of Molecular Neuroscience : Mn. 17: 233-57. PMID 11816796 DOI: 10.1385/Jmn:17:2:233 |
0.702 |
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| 2001 |
Watanabe M, Dykes-Hoberg M, Culotta VC, Price DL, Wong PC, Rothstein JD. Histological evidence of protein aggregation in mutant SOD1 transgenic mice and in amyotrophic lateral sclerosis neural tissues. Neurobiology of Disease. 8: 933-41. PMID 11741389 DOI: 10.1006/nbdi.2001.0443 |
0.593 |
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| 2001 |
Lesuisse C, Xu G, Anderson J, Wong M, Jankowsky J, Holtz G, Gonzalez V, Wong PC, Price DL, Tang F, Wagner S, Borchelt DR. Hyper-expression of human apolipoprotein E4 in astroglia and neurons does not enhance amyloid deposition in transgenic mice. Human Molecular Genetics. 10: 2525-37. PMID 11709540 DOI: 10.1093/Hmg/10.22.2525 |
0.603 |
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| 2001 |
Wong PC, Price DL, Cai H. The brain's susceptibility to amyloid plaques. Science (New York, N.Y.). 293: 1434. PMID 11526940 DOI: 10.1126/Science.293.5534.1434B |
0.69 |
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| 2001 |
Cai H, Wang Y, McCarthy D, Wen H, Borchelt DR, Price DL, Wong PC. BACE1 is the major beta-secretase for generation of Abeta peptides by neurons. Nature Neuroscience. 4: 233-4. PMID 11224536 DOI: 10.1038/85064 |
0.701 |
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| 2000 |
Price DL, Wong PC, Markowska AL, Lee MK, Thinakaren G, Cleveland DW, Sisodia SS, Borchelt DR. The value of transgenic models for the study of neurodegenerative diseases. Annals of the New York Academy of Sciences. 920: 179-91. PMID 11193148 DOI: 10.1111/J.1749-6632.2000.Tb06920.X |
0.63 |
|
| 2000 |
Wong PC, Waggoner D, Subramaniam JR, Tessarollo L, Bartnikas TB, Culotta VC, Price DL, Rothstein J, Gitlin JD. Copper chaperone for superoxide dismutase is essential to activate mammalian Cu/Zn superoxide dismutase. Proceedings of the National Academy of Sciences of the United States of America. 97: 2886-91. PMID 10694572 DOI: 10.1073/Pnas.040461197 |
0.526 |
|
| 1999 |
Rothstein JD, Dykes-Hoberg M, Corson LB, Becker M, Cleveland DW, Price DL, Culotta VC, Wong PC. The copper chaperone CCS is abundant in neurons and astrocytes in human and rodent brain. Journal of Neurochemistry. 72: 422-9. PMID 9886096 DOI: 10.1046/j.1471-4159.1999.0720422.x |
0.557 |
|
| 1998 |
Wong PC, Borchelt DR, Lee MK, Pardo CA, Thinakaran G, Martin LJ, Sisodia SS, Price DL. Familial amyotrophic lateral sclerosis and Alzheimer's disease. Transgenic models. Advances in Experimental Medicine and Biology. 446: 145-59. PMID 10079842 DOI: 10.1007/978-1-4615-4869-0_9 |
0.663 |
|
| 1998 |
Wong PC, Rothstein JD, Price DL. The genetic and molecular mechanisms of motor neuron disease. Current Opinion in Neurobiology. 8: 791-9. PMID 9914243 DOI: 10.1016/S0959-4388(98)80123-2 |
0.637 |
|
| 1998 |
Naruse S, Thinakaran G, Luo JJ, Kusiak JW, Tomita T, Iwatsubo T, Qian X, Ginty DD, Price DL, Borchelt DR, Wong PC, Sisodia SS. Effects of PS1 deficiency on membrane protein trafficking in neurons. Neuron. 21: 1213-21. PMID 9856475 DOI: 10.1016/S0896-6273(00)80637-6 |
0.562 |
|
| 1998 |
Borchelt DR, Wong PC, Sisodia SS, Price DL. Transgenic mouse models of Alzheimer's disease and amyotrophic lateral sclerosis. Brain Pathology (Zurich, Switzerland). 8: 735-57. PMID 9804381 DOI: 10.1111/J.1750-3639.1998.Tb00198.X |
0.652 |
|
| 1998 |
Borchelt DR, Wong PC, Becher MW, Pardo CA, Lee MK, Xu ZS, Thinakaran G, Jenkins NA, Copeland NG, Sisodia SS, Cleveland DW, Price DL, Hoffman PN. Axonal transport of mutant superoxide dismutase 1 and focal axonal abnormalities in the proximal axons of transgenic mice. Neurobiology of Disease. 5: 27-35. PMID 9702785 DOI: 10.1006/Nbdi.1998.0178 |
0.572 |
|
| 1998 |
Couillard-Després S, Zhu Q, Wong PC, Price DL, Cleveland DW, Julien JP. Protective effect of neurofilament heavy gene overexpression in motor neuron disease induced by mutant superoxide dismutase. Proceedings of the National Academy of Sciences of the United States of America. 95: 9626-30. PMID 9689131 DOI: 10.1073/Pnas.95.16.9626 |
0.631 |
|
| 1998 |
Davis JA, Naruse S, Chen H, Eckman C, Younkin S, Price DL, Borchelt DR, Sisodia SS, Wong PC. An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos. Neuron. 20: 603-9. PMID 9539132 DOI: 10.1016/S0896-6273(00)80998-8 |
0.636 |
|
| 1998 |
Eyer J, Cleveland DW, Wong PC, Peterson AC. Pathogenesis of two axonopathies does not require axonal neurofilaments. Nature. 391: 584-7. PMID 9468135 DOI: 10.1038/35378 |
0.356 |
|
| 1997 |
Price DL, Wong PC, Borchelt DR, Pardo CA, Thinakaran G, Doan AP, Lee MK, Martin LJ, Sisodia SS. Amyotrophic lateral sclerosis and Alzheimer disease. Lessons from model systems. Revue Neurologique. 153: 484-95. PMID 9683997 |
0.656 |
|
| 1997 |
Bruijn LI, Beal MF, Becher MW, Schulz JB, Wong PC, Price DL, Cleveland DW. Elevated free nitrotyrosine levels, but not protein-bound nitrotyrosine or hydroxyl radicals, throughout amyotrophic lateral sclerosis (ALS)-like disease implicate tyrosine nitration as an aberrant in vivo property of one familial ALS-linked superoxide dismutase 1 mutant. Proceedings of the National Academy of Sciences of the United States of America. 94: 7606-11. PMID 9207139 DOI: 10.1073/Pnas.94.14.7606 |
0.629 |
|
| 1997 |
Wong PC, Zheng H, Chen H, Becher MW, Sirinathsinghji DJ, Trumbauer ME, Chen HY, Price DL, Van der Ploeg LH, Sisodia SS. Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm. Nature. 387: 288-92. PMID 9153393 DOI: 10.1038/387288a0 |
0.581 |
|
| 1996 |
Price DL, Becher MW, Wong PC, Borchelt DR, Lee MK, Sisodia SS. Inherited neurodegenerative diseases and transgenic models. Brain Pathology (Zurich, Switzerland). 6: 467-80. PMID 8944317 DOI: 10.1111/J.1750-3639.1996.Tb00876.X |
0.628 |
|
| 1996 |
Lee MK, Borchelt DR, Wong PC, Sisodia SS, Price DL. Transgenic models of neurodegenerative diseases. Current Opinion in Neurobiology. 6: 651-60. PMID 8937830 DOI: 10.1016/S0959-4388(96)80099-7 |
0.642 |
|
| 1996 |
Price DL, Koliatsos VE, Wong PC, Pardo CA, Borchelt DR, Lee MK, Cleveland DW, Griffin JW, Hoffman PN, Cork LC, Sisodia SS. Motor neuron disease and model systems: aetiologies, mechanisms and therapies. Ciba Foundation Symposium. 196: 3-13; discussion 13-. PMID 8866125 |
0.622 |
|
| 1996 |
Cleveland DW, Bruijn LI, Wong PC, Marszalek JR, Vechio JD, Lee MK, Xu XS, Borchelt DR, Sisodia SS, Price DL. Mechanisms of selective motor neuron death in transgenic mouse models of motor neuron disease. Neurology. 47: S54-61; discussion S. PMID 8858052 DOI: 10.1212/Wnl.47.4_Suppl_2.54S |
0.622 |
|
| 1996 |
Price D, Borchelt D, Lee M, Wong P, Martin L, Sisodia S. 631 Neurodegenerative Diseases and Model Systems Neurobiology of Aging. 17: S157. DOI: 10.1016/S0197-4580(96)80633-6 |
0.572 |
|
| 1996 |
Wong PC, Borchelt DR, Lee MK, Pardo CA, Sisodia SS, Cleveland DW, Koliatsos VE, Price DL. Transgenic and gene-targeting approaches to model disorders of motor neurons Seminars in Neuroscience. 8: 163-169. DOI: 10.1006/Smns.1996.0021 |
0.645 |
|
| 1995 |
Borchelt DR, Guarnieri M, Wong PC, Lee MK, Slunt HS, Xu ZS, Sisodia SS, Price DL, Cleveland DW. Superoxide dismutase 1 subunits with mutations linked to familial amyotrophic lateral sclerosis do not affect wild-type subunit function. The Journal of Biological Chemistry. 270: 3234-8. PMID 7852409 DOI: 10.1074/Jbc.270.7.3234 |
0.596 |
|
| 1995 |
Wong PC, Pardo CA, Borchelt DR, Lee MK, Copeland NG, Jenkins NA, Sisodia SS, Cleveland DW, Price DL. An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria. Neuron. 14: 1105-16. PMID 7605627 DOI: 10.1016/0896-6273(95)90259-7 |
0.621 |
|
| 1995 |
Wong PC, Borchelt DR. Motor neuron disease caused by mutations in superoxide dismutase 1. Current Opinion in Neurology. 8: 294-301. PMID 7582045 DOI: 10.1097/00019052-199508000-00008 |
0.306 |
|
| 1995 |
Pardo CA, Wong PC, Cleveland DW, Price DL. Gain Of An Adverse Property By A Mutant Sod1 Enzyme Produce Extensive Motor Neuron Abnormalities In Transgenic Mice: 124 Journal of Neuropathology and Experimental Neurology. 54: 442. DOI: 10.1097/00005072-199505000-00140 |
0.617 |
|
| 1994 |
Borchelt DR, Lee MK, Slunt HS, Guarnieri M, Xu ZS, Wong PC, Brown RH, Price DL, Sisodia SS, Cleveland DW. Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity. Proceedings of the National Academy of Sciences of the United States of America. 91: 8292-6. PMID 8058797 DOI: 10.1073/Pnas.91.17.8292 |
0.544 |
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