| Year |
Citation |
Score |
| 2023 |
Yang MH, Tran TH, Hunt B, Agnor R, Johnson CW, Shui B, Waybright TJ, Nowak JA, Stephen AG, Simanshu DK, Haigis KM. Allosteric regulation of switch-II domain controls KRAS oncogenicity. Cancer Research. PMID 37556505 DOI: 10.1158/0008-5472.CAN-22-3210 |
0.319 |
|
| 2022 |
Huynh MV, Hobbs GA, Schaefer A, Pierobon M, Carey LM, Diehl JN, DeLiberty JM, Thurman RD, Cooke AR, Goodwin CM, Cook JH, Lin L, Waters AM, Rashid NU, Petricoin EF, ... ... Haigis KM, et al. Functional and biological heterogeneity of KRAS mutations. Science Signaling. 15: eabn2694. PMID 35944066 DOI: 10.1126/scisignal.abn2694 |
0.315 |
|
| 2022 |
Johnson C, Burkhart DL, Haigis KM. Classification of KRAS-Activating Mutations and the Implications for Therapeutic Intervention. Cancer Discovery. 12: 913-923. PMID 35373279 DOI: 10.1158/2159-8290.CD-22-0035 |
0.317 |
|
| 2020 |
Ferguson FM, Nabet B, Raghavan S, Liu Y, Leggett AL, Kuljanin M, Kalekar RL, Yang A, He S, Wang J, Ng RWS, Sulahian R, Li L, Poulin EJ, Huang L, ... ... Haigis KM, et al. Discovery of a selective inhibitor of doublecortin like kinase 1. Nature Chemical Biology. PMID 32251410 DOI: 10.1038/S41589-020-0506-0 |
0.308 |
|
| 2020 |
Zambetti NA, Firestone AJ, Remsberg JR, Huang BJ, Wong JC, Long AM, Predovic M, Suciu RM, Inguva A, Kogan SC, Haigis KM, Cravatt BF, Shannon K. Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice. Blood. PMID 32219446 DOI: 10.1182/Blood.2019003530 |
0.466 |
|
| 2020 |
Haigis K. Abstract IA29: Global proteomics reveals the context-dependence of K-Ras signaling Molecular Cancer Research. 18. DOI: 10.1158/1557-3125.Ras18-Ia29 |
0.432 |
|
| 2020 |
Zambetti NA, Firestone AJ, Wong JC, Long AM, Inguva A, Remsberg JR, Suciu RM, Cravatt BF, Haigis KM, Shannon K. Abstract A25: In vivo evidence validating the palmitoylation/depalmitoylation cycle as a therapeutic target in NRAS mutant hematologic cancers Molecular Cancer Research. 18. DOI: 10.1158/1557-3125.Ras18-A25 |
0.44 |
|
| 2020 |
Lin Y, Dischinger P, Graveel C, Steensma M, Haigis KM. Abstract A18: Characterization of K-RasG13D as a unique activating allele in a mouse model of colorectal cancer Molecular Cancer Research. 18. DOI: 10.1158/1557-3125.Ras18-A18 |
0.449 |
|
| 2020 |
Yang MH, Hunt B, Johnson C, Simanshu D, Haigis K. Abstract B47: Mutation of K104 abrogates the oncogenic properties of K-RasG12D Cancer Research. 80. DOI: 10.1158/1538-7445.Camodels2020-B47 |
0.419 |
|
| 2019 |
Brubaker DK, Paulo JA, Sheth S, Poulin EJ, Popow O, Joughin BA, Strasser SD, Starchenko A, Gygi SP, Lauffenburger DA, Haigis KM. Proteogenomic Network Analysis of Context-Specific KRAS Signaling in Mouse-to-Human Cross-Species Translation. Cell Systems. PMID 31521603 DOI: 10.1016/J.Cels.2019.07.006 |
0.414 |
|
| 2019 |
Johnson CW, Lin YJ, Reid D, Parker J, Pavlopoulos S, Dischinger P, Graveel C, Aguirre AJ, Steensma M, Haigis KM, Mattos C. Isoform-Specific Destabilization of the Active Site Reveals a Molecular Mechanism of Intrinsic Activation of KRas G13D. Cell Reports. 28: 1538-1550.e7. PMID 31390567 DOI: 10.1016/J.Celrep.2019.07.026 |
0.402 |
|
| 2019 |
Popow O, Paulo JA, Tatham MH, Volk MS, Rojas-Fernandez A, Loyer N, Newton IP, Januschke J, Haigis KM, Nathke I. Identification of endogenous Adenomatous polyposis coli interaction partners and β-catenin-independent targets by proteomics. Molecular Cancer Research : McR. PMID 31160382 DOI: 10.1158/1541-7786.Mcr-18-1154 |
0.366 |
|
| 2019 |
Poulin EJ, Bera AK, Lu J, Lin YJ, Strasser SD, Paulo JA, Huang TQ, Morales C, Yan W, Cook J, Nowak JA, Brubaker DK, Joughin BA, Johnson CW, DeStefanis RA, ... ... Haigis KM, et al. Tissue-specific oncogenic activity of K-RasA146T. Cancer Discovery. PMID 30952657 DOI: 10.1158/2159-8290.Cd-18-1220 |
0.429 |
|
| 2019 |
Haigis KM, Cichowski K, Elledge SJ. Tissue-specificity in cancer: The rule, not the exception. Science (New York, N.Y.). 363: 1150-1151. PMID 30872507 DOI: 10.1126/Science.Aaw3472 |
0.617 |
|
| 2018 |
Suarez-Lopez L, Sriram G, Kong YW, Morandell S, Merrick KA, Hernandez Y, Haigis KM, Yaffe MB. MK2 contributes to tumor progression by promoting M2 macrophage polarization and tumor angiogenesis. Proceedings of the National Academy of Sciences of the United States of America. PMID 29666270 DOI: 10.1073/Pnas.1722020115 |
0.354 |
|
| 2018 |
Lyons J, Ghazi PC, Starchenko A, Tovaglieri A, Baldwin KR, Poulin EJ, Gierut JJ, Genetti C, Yajnik V, Breault DT, Lauffenburger DA, Haigis KM. The colonic epithelium plays an active role in promoting colitis by shaping the tissue cytokine profile. Plos Biology. 16: e2002417. PMID 29596476 DOI: 10.1371/Journal.Pbio.2002417 |
0.331 |
|
| 2018 |
Lyons J, Brubaker DK, Ghazi PC, Baldwin KR, Edwards A, Boukhali M, Strasser SD, Suarez-Lopez L, Lin YJ, Yajnik V, Kissil JL, Haas W, Lauffenburger DA, Haigis KM. Integrated in vivo multiomics analysis identifies p21-activated kinase signaling as a driver of colitis. Science Signaling. 11. PMID 29487189 DOI: 10.1126/Scisignal.Aan3580 |
0.334 |
|
| 2018 |
Lin YJ, Haigis KM. Brother's Keeper: Wild-Type Mutant K-Ras Dimers Limit Oncogenesis. Cell. 172: 645-647. PMID 29425486 DOI: 10.1016/J.Cell.2018.01.019 |
0.379 |
|
| 2018 |
Hong TS, Wo JY, Ryan DP, Zheng H, Borger DR, Kwak EL, Allen JN, Berger DL, Rattner DW, Cusack JC, Gemma AJ, Mamon HJ, Eyler CE, Shellito PC, Zhu AX, ... ... Haigis KM, et al. Phase Ib study of neoadjuvant chemoradiation (CRT) with midostaurin, 5-fluorouracil (5-FU) and radiation (XRT) for locally advanced rectal cancer: Sensitization of RAS mutant tumors. Journal of Clinical Oncology. 36: e15674-e15674. DOI: 10.1200/Jco.2018.36.15_Suppl.E15674 |
0.421 |
|
| 2018 |
Poulin E, Gierut J, Haigis K. Abstract B04: Activating K-RasA146T mutations induce Mapk-dependent hyperproliferation in the intestinal epithelium Cancer Research. 78. DOI: 10.1158/1538-7445.Mousemodels17-B04 |
0.457 |
|
| 2017 |
Haigis KM. KRAS Alleles: The Devil Is in the Detail. Trends in Cancer. 3: 686-697. PMID 28958387 DOI: 10.1016/J.Trecan.2017.08.006 |
0.397 |
|
| 2017 |
Martin TD, Cook DR, Choi MY, Li MZ, Haigis KM, Elledge SJ. A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells. Cell Reports. 20: 427-438. PMID 28700943 DOI: 10.1016/J.Celrep.2017.06.061 |
0.442 |
|
| 2017 |
Poulin EJ, Haigis KM. No back seat for a progression event-K-RAS as a therapeutic target in CRC. Genes & Development. 31: 333-335. PMID 28314765 DOI: 10.1101/Gad.297630.117 |
0.458 |
|
| 2016 |
Nicolay BN, Danielian PS, Kottakis F, Lapek JD, Sanidas I, Miles WO, Dehnad M, Tschöp K, Gierut JJ, Manning AL, Morris R, Haigis K, Bardeesy N, Lees JA, Haas W, et al. Abstract IA15: The consequences of pRb inactivation: insights from a proteomic analysis of Rb loss Molecular Cancer Research. 14. DOI: 10.1158/1557-3125.Cellcycle16-Ia15 |
0.381 |
|
| 2016 |
Haigis K. Abstract IA17: The global phospho-proteome of K-Ras mutant cells and tissues Cancer Research. 76. DOI: 10.1158/1538-7445.Panca16-Ia17 |
0.379 |
|
| 2015 |
Nicolay BN, Danielian PS, Kottakis F, Lapek JD, Sanidas I, Miles WO, Dehnad M, Tschöp K, Gierut JJ, Manning AL, Morris R, Haigis K, Bardeesy N, Lees JA, Haas W, et al. Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation. Genes & Development. 29: 1875-89. PMID 26314710 DOI: 10.1101/Gad.264127.115 |
0.327 |
|
| 2015 |
Gierut JJ, Lyons J, Shah MS, Genetti C, Breault DT, Haigis KM. Oncogenic K-Ras promotes proliferation in quiescent intestinal stem cells. Stem Cell Research. 15: 165-71. PMID 26079371 DOI: 10.1016/J.Scr.2015.06.003 |
0.404 |
|
| 2015 |
Depeille P, Henricks LM, van de Ven RA, Lemmens E, Wang CY, Matli M, Werb Z, Haigis KM, Donner D, Warren R, Roose JP. RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth. Nature Cell Biology. 17: 804-15. PMID 26005835 DOI: 10.1038/Ncb3175 |
0.418 |
|
| 2015 |
Bender RH, Haigis KM, Gutmann DH. Activated k-ras, but not h-ras or N-ras, regulates brain neural stem cell proliferation in a raf/rb-dependent manner. Stem Cells (Dayton, Ohio). 33: 1998-2010. PMID 25788415 DOI: 10.1002/Stem.1990 |
0.393 |
|
| 2015 |
Tsai FD, Lopes MS, Zhou M, Court H, Ponce O, Fiordalisi JJ, Gierut JJ, Cox AD, Haigis KM, Philips MR. K-Ras4A splice variant is widely expressed in cancer and uses a hybrid membrane-targeting motif. Proceedings of the National Academy of Sciences of the United States of America. 112: 779-84. PMID 25561545 DOI: 10.1073/Pnas.1412811112 |
0.338 |
|
| 2015 |
Kamran S, Russo A, Borger D, Szymonifka J, Kwak E, Clark J, Blaszkowsky L, Ryan D, Allen J, Wo J, Zhu A, Iafrate A, Haigis K, Hong T. Influence of Body Mass Index (BMI) on Colorectal Cancer Mutation Status International Journal of Radiation Oncology*Biology*Physics. 93: E155. DOI: 10.1016/J.Ijrobp.2015.07.943 |
0.314 |
|
| 2014 |
Burgess MR, Hwang E, Firestone AJ, Huang T, Xu J, Zuber J, Bohin N, Wen T, Kogan SC, Haigis KM, Sampath D, Lowe S, Shannon K, Li Q. Preclinical efficacy of MEK inhibition in Nras-mutant AML. Blood. 124: 3947-55. PMID 25361812 DOI: 10.1182/Blood-2014-05-574582 |
0.57 |
|
| 2014 |
Jun HJ, Roy J, Smith TB, Wood LB, Lane K, Woolfenden S, Punko D, Bronson RT, Haigis KM, Breton S, Charest A. ROS1 signaling regulates epithelial differentiation in the epididymis. Endocrinology. 155: 3661-73. PMID 24971615 DOI: 10.1210/En.2014-1341 |
0.308 |
|
| 2014 |
Imamura Y, Lochhead P, Yamauchi M, Kuchiba A, Qian ZR, Liao X, Nishihara R, Jung S, Wu K, Nosho K, Wang YE, Peng S, Bass AJ, Haigis KM, Meyerhardt JA, et al. Analyses of clinicopathological, molecular, and prognostic associations of KRAS codon 61 and codon 146 mutations in colorectal cancer: cohort study and literature review. Molecular Cancer. 13: 135. PMID 24885062 DOI: 10.1186/1476-4598-13-135 |
0.366 |
|
| 2014 |
Gierut JJ, Jacks TE, Haigis KM. Whole-mount X-Gal staining of mouse tissues. Cold Spring Harbor Protocols. 2014: 417-9. PMID 24692489 DOI: 10.1101/Pdb.Prot073452 |
0.611 |
|
| 2014 |
Gierut JJ, Jacks TE, Haigis KM. Strategies to achieve conditional gene mutation in mice. Cold Spring Harbor Protocols. 2014: 339-49. PMID 24692485 DOI: 10.1101/Pdb.Top069807 |
0.647 |
|
| 2014 |
Gierut JJ, Jacks TE, Haigis KM. In vivo delivery of lenti-Cre or adeno-Cre into mice using intranasal instillation. Cold Spring Harbor Protocols. 2014: 307-9. PMID 24591689 DOI: 10.1101/Pdb.Prot073445 |
0.628 |
|
| 2014 |
Gierut JJ, Jacks TE, Haigis KM. Producing and concentrating lenti-Cre for mouse infections. Cold Spring Harbor Protocols. 2014: 304-6. PMID 24591688 DOI: 10.1101/Pdb.Prot073437 |
0.589 |
|
| 2014 |
Russo AL, Borger DR, Szymonifka J, Ryan DP, Wo JY, Blaszkowsky LS, Kwak EL, Allen JN, Wadlow RC, Zhu AX, Murphy JE, Faris JE, Dias-Santagata D, Haigis KM, Ellisen LW, et al. Mutational analysis and clinical correlation of metastatic colorectal cancer. Cancer. 120: 1482-90. PMID 24500602 DOI: 10.1002/Cncr.28599 |
0.358 |
|
| 2014 |
Russo AL, Ryan DP, Borger DR, Wo JY, Szymonifka J, Liang WY, Kwak EL, Blaszkowsky LS, Clark JW, Allen JN, Zhu AX, Berger DL, Cusack JC, Mamon HJ, Haigis KM, et al. Mutational and clinical predictors of pathologic complete response in the treatment of locally advanced rectal cancer. Journal of Gastrointestinal Cancer. 45: 34-9. PMID 24006244 DOI: 10.1007/S12029-013-9546-Y |
0.353 |
|
| 2014 |
Burgess MR, Hwang E, Firestone AJ, Huang T, Xu J, Zuber J, Bohin N, Wen T, Kogan SC, Haigis KM, Lowe SW, Shannon K, Li Q. Preclinical Efficacy of MEK Inhibition in Nras Mutant Acute Myeloid Leukemia Blood. 124: 3753-3753. DOI: 10.1182/Blood.V124.21.3753.3753 |
0.586 |
|
| 2014 |
Haigis KM. Abstract IA03: Regulation of K-Ras function by lysine acetylation Molecular Cancer Research. 12. DOI: 10.1158/1557-3125.Rasonc14-Ia03 |
0.404 |
|
| 2014 |
Gierut JJ, Haigis KM. Abstract B06: Functional characterization of K-RAS A146T in colorectal cancer Molecular Cancer Research. 12. DOI: 10.1158/1557-3125.Rasonc14-B06 |
0.474 |
|
| 2014 |
Depeille P, Henricks LM, Ven Rvd, Lemmens E, Matli M, Haigis KM, Donner D, Warren R, Roose JP. Abstract LB-306: The Ras exchange factor RasGRP1 opposes proliferative EGFR-SOS1 Ras signals and restricts intestinal epithelial cell growth Cancer Research. 74. DOI: 10.1158/1538-7445.Am2014-Lb-306 |
0.419 |
|
| 2013 |
Kleiman LB, Krebs AM, Kim SY, Hong TS, Haigis KM. Comparative analysis of radiosensitizers for K-RAS mutant rectal cancers. Plos One. 8: e82982. PMID 24349411 DOI: 10.1371/Journal.Pone.0082982 |
0.441 |
|
| 2013 |
Lau KS, Schrier SB, Gierut J, Lyons J, Lauffenburger DA, Haigis KM. Network analysis of differential Ras isoform mutation effects on intestinal epithelial responses to TNF-α. Integrative Biology : Quantitative Biosciences From Nano to Macro. 5: 1355-65. PMID 24084984 DOI: 10.1039/C3Ib40062J |
0.43 |
|
| 2013 |
Xu J, Haigis KM, Firestone AJ, McNerney ME, Li Q, Davis E, Chen SC, Nakitandwe J, Downing J, Jacks T, Le Beau MM, Shannon K. Dominant role of oncogene dosage and absence of tumor suppressor activity in Nras-driven hematopoietic transformation. Cancer Discovery. 3: 993-1001. PMID 23733505 DOI: 10.1158/2159-8290.Cd-13-0096 |
0.699 |
|
| 2013 |
Yang MH, Laurent G, Bause AS, Spang R, German N, Haigis MC, Haigis KM. HDAC6 and SIRT2 regulate the acetylation state and oncogenic activity of mutant K-RAS. Molecular Cancer Research : McR. 11: 1072-7. PMID 23723075 DOI: 10.1158/1541-7786.Mcr-13-0040-T |
0.433 |
|
| 2013 |
Wang Y, Velho S, Vakiani E, Peng S, Bass AJ, Chu GC, Gierut J, Bugni JM, Der CJ, Philips M, Solit DB, Haigis KM. Mutant N-RAS protects colorectal cancer cells from stress-induced apoptosis and contributes to cancer development and progression. Cancer Discovery. 3: 294-307. PMID 23274911 DOI: 10.1158/2159-8290.Cd-12-0198 |
0.472 |
|
| 2013 |
Russo AL, Ryan DP, Borger DR, Wo JY, Szymonifka J, Kwak EL, Blaszkowsky LS, Clark JW, Allen JN, Zhu AX, Berger DL, Cusack JC, Haigis KM, Hong TS. Mutational analysis of locally advanced rectal cancer and response to neoadjuvant chemoradiation. Journal of Clinical Oncology. 31: 449-449. DOI: 10.1200/Jco.2013.31.4_Suppl.449 |
0.36 |
|
| 2013 |
Kleiman LB, Krebs A, Kim S, Hong TS, Haigis KM. Abstract 4440: Identification and characterization of small molecule inhibitors that radiosensitize K-RAS mutant rectal cancers. Cancer Research. 73: 4440-4440. DOI: 10.1158/1538-7445.Am2013-4440 |
0.43 |
|
| 2012 |
Lau KS, Cortez-Retamozo V, Philips SR, Pittet MJ, Lauffenburger DA, Haigis KM. Multi-scale in vivo systems analysis reveals the influence of immune cells on TNF-α-induced apoptosis in the intestinal epithelium. Plos Biology. 10: e1001393. PMID 23055830 DOI: 10.1371/Journal.Pbio.1001393 |
0.309 |
|
| 2012 |
Lau KS, Zhang T, Kendall KR, Lauffenburger D, Gray NS, Haigis KM. BAY61-3606 affects the viability of colon cancer cells in a genotype-directed manner. Plos One. 7: e41343. PMID 22815993 DOI: 10.1371/Journal.Pone.0041343 |
0.425 |
|
| 2012 |
Imamura Y, Morikawa T, Liao X, Lochhead P, Kuchiba A, Yamauchi M, Qian ZR, Nishihara R, Meyerhardt JA, Haigis KM, Fuchs CS, Ogino S. Specific mutations in KRAS codons 12 and 13, and patient prognosis in 1075 BRAF wild-type colorectal cancers. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: 4753-63. PMID 22753589 DOI: 10.1158/1078-0432.Ccr-11-3210 |
0.402 |
|
| 2012 |
Yang MH, Nickerson S, Kim ET, Liot C, Laurent G, Spang R, Philips MR, Shan Y, Shaw DE, Bar-Sagi D, Haigis MC, Haigis KM. Regulation of RAS oncogenicity by acetylation. Proceedings of the National Academy of Sciences of the United States of America. 109: 10843-8. PMID 22711838 DOI: 10.1073/Pnas.1201487109 |
0.399 |
|
| 2012 |
Hong TS, Clark JW, Haigis KM. Cancers of the colon and rectum: identical or fraternal twins? Cancer Discovery. 2: 117-21. PMID 22585856 DOI: 10.1158/2159-8290.Cd-11-0315 |
0.308 |
|
| 2012 |
Powell AE, Wang Y, Li Y, Poulin EJ, Means AL, Washington MK, Higginbotham JN, Juchheim A, Prasad N, Levy SE, Guo Y, Shyr Y, Aronow BJ, Haigis KM, Franklin JL, et al. The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor. Cell. 149: 146-58. PMID 22464327 DOI: 10.1016/J.Cell.2012.02.042 |
0.318 |
|
| 2012 |
Ahearn IM, Haigis K, Bar-Sagi D, Philips MR. Regulating the regulator: post-translational modification of RAS. Nature Reviews. Molecular Cell Biology. 13: 39-51. PMID 22189424 DOI: 10.1038/Nrm3255 |
0.356 |
|
| 2012 |
Xu J, Hedberg C, Dekker FJ, Li Q, Haigis KM, Hwang E, Waldmann H, Shannon K. Inhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic Nras. Blood. 119: 1032-5. PMID 22144181 DOI: 10.1182/Blood-2011-06-358960 |
0.437 |
|
| 2011 |
Velho S, Haigis KM. Regulation of homeostasis and oncogenesis in the intestinal epithelium by Ras. Experimental Cell Research. 317: 2732-9. PMID 21741971 DOI: 10.1016/J.Yexcr.2011.06.002 |
0.447 |
|
| 2011 |
Lau KS, Juchheim AM, Cavaliere KR, Philips SR, Lauffenburger DA, Haigis KM. In vivo systems analysis identifies spatial and temporal aspects of the modulation of TNF-α-induced apoptosis and proliferation by MAPKs. Science Signaling. 4: ra16. PMID 21427409 DOI: 10.1126/Scisignal.2001338 |
0.31 |
|
| 2011 |
Haigis KM, Sweet-Cordero A. New insights into oncogenic stress. Nature Genetics. 43: 177-8. PMID 21350495 DOI: 10.1038/Ng0311-177 |
0.373 |
|
| 2011 |
Li Q, Haigis KM, McDaniel A, Harding-Theobald E, Kogan SC, Akagi K, Wong JC, Braun BS, Wolff L, Jacks T, Shannon K. Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus. Blood. 117: 2022-32. PMID 21163920 DOI: 10.1182/Blood-2010-04-280750 |
0.686 |
|
| 2011 |
Wang Y, Powell AE, Li Y, Davenport JR, Franklin J, Haigis KM, Coffey RJ. Abstract 5188: Lrig1, a cell surface negative regulator of ErbB1-4, marks both proliferative and quiescent intestinal stem cells and acts as a tumor suppressor Cancer Research. 71: 5188-5188. DOI: 10.1158/1538-7445.Am2011-5188 |
0.388 |
|
| 2011 |
Powell A, Li Y, Wang Y, Franklin J, Haigis K, Coffey RJ. Lrig1 Marks a Distinct Population of Proliferative and Quiescent Intestinal Stem Cells and Acts as a Tumor Suppressor Gastroenterology. 140: S-39. DOI: 10.1016/S0016-5085(11)60153-4 |
0.383 |
|
| 2010 |
Tanaka N, Huttenhower C, Nosho K, Baba Y, Shima K, Quackenbush J, Haigis KM, Giovannucci E, Fuchs CS, Ogino S. Novel application of structural equation modeling to correlation structure analysis of CpG island methylation in colorectal cancer. The American Journal of Pathology. 177: 2731-40. PMID 21037082 DOI: 10.2353/Ajpath.2010.100361 |
0.36 |
|
| 2010 |
Irahara N, Baba Y, Nosho K, Shima K, Yan L, Dias-Santagata D, Iafrate AJ, Fuchs CS, Haigis KM, Ogino S. NRAS mutations are rare in colorectal cancer. Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B. 19: 157-63. PMID 20736745 DOI: 10.1097/Pdm.0B013E3181C93Fd1 |
0.404 |
|
| 2010 |
Kreeger PK, Wang Y, Haigis KM, Lauffenburger DA. Integration of multiple signaling pathway activities resolves K-RAS/N-RAS mutation paradox in colon epithelial cell response to inflammatory cytokine stimulation. Integrative Biology : Quantitative Biosciences From Nano to Macro. 2: 202-8. PMID 20473400 DOI: 10.1039/B925935J |
0.441 |
|
| 2010 |
Kirsch DG, Santiago PM, di Tomaso E, Sullivan JM, Hou WS, Dayton T, Jeffords LB, Sodha P, Mercer KL, Cohen R, Takeuchi O, Korsmeyer SJ, Bronson RT, Kim CF, Haigis KM, et al. p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis. Science (New York, N.Y.). 327: 593-6. PMID 20019247 DOI: 10.1126/Science.1166202 |
0.712 |
|
| 2010 |
Cheung AF, Carter AM, Kostova KK, Woodruff JF, Crowley D, Bronson RT, Haigis KM, Jacks T. Complete deletion of Apc results in severe polyposis in mice. Oncogene. 29: 1857-64. PMID 20010873 DOI: 10.1038/Onc.2009.457 |
0.672 |
|
| 2010 |
Ogino S, Tanaka N, Nosho K, Huttenhower C, Quackenbush J, Haigis K, Fuchs C. Abstract 4922:KRASandBRAFmutations influence correlation structure of locus-specific CpG island methylation and CIMP in colorectal cancer Cancer Research. 70: 4922-4922. DOI: 10.1158/1538-7445.Am10-4922 |
0.357 |
|
| 2009 |
Lau KS, Haigis KM. Non-redundancy within the RAS oncogene family: insights into mutational disparities in cancer. Molecules and Cells. 28: 315-20. PMID 19812895 DOI: 10.1007/S10059-009-0143-7 |
0.413 |
|
| 2009 |
Kreeger PK, Mandhana R, Alford SK, Haigis KM, Lauffenburger DA. RAS mutations affect tumor necrosis factor-induced apoptosis in colon carcinoma cells via ERK-modulatory negative and positive feedback circuits along with non-ERK pathway effects. Cancer Research. 69: 8191-9. PMID 19789336 DOI: 10.1158/0008-5472.Can-09-1921 |
0.441 |
|
| 2009 |
Ianari A, Natale T, Calo E, Ferretti E, Alesse E, Screpanti I, Haigis K, Gulino A, Lees JA. Proapoptotic function of the retinoblastoma tumor suppressor protein. Cancer Cell. 15: 184-94. PMID 19249677 DOI: 10.1016/J.Ccr.2009.01.026 |
0.341 |
|
| 2008 |
Haigis KM, Kendall KR, Wang Y, Cheung A, Haigis MC, Glickman JN, Niwa-Kawakita M, Sweet-Cordero A, Sebolt-Leopold J, Shannon KM, Settleman J, Giovannini M, Jacks T. Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon. Nature Genetics. 40: 600-8. PMID 18372904 DOI: 10.1038/Ng.115 |
0.693 |
|
| 2008 |
Kwong LN, Weiss KR, Haigis KM, Dove WF. Atm is a negative regulator of intestinal neoplasia. Oncogene. 27: 1013-8. PMID 17700532 DOI: 10.1038/Sj.Onc.1210708 |
0.72 |
|
| 2007 |
Kissil JL, Walmsley MJ, Hanlon L, Haigis KM, Bender Kim CF, Sweet-Cordero A, Eckman MS, Tuveson DA, Capobianco AJ, Tybulewicz VL, Jacks T. Requirement for Rac1 in a K-ras induced lung cancer in the mouse. Cancer Research. 67: 8089-94. PMID 17804720 DOI: 10.1158/0008-5472.Can-07-2300 |
0.722 |
|
| 2007 |
Poutahidis T, Haigis KM, Rao VP, Nambiar PR, Taylor CL, Ge Z, Watanabe K, Davidson A, Horwitz BH, Fox JG, Erdman SE. Rapid reversal of interleukin-6-dependent epithelial invasion in a mouse model of microbially induced colon carcinoma. Carcinogenesis. 28: 2614-23. PMID 17724375 DOI: 10.1093/Carcin/Bgm180 |
0.324 |
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| 2007 |
Kaiser S, Park YK, Franklin JL, Halberg RB, Yu M, Jessen WJ, Freudenberg J, Chen X, Haigis K, Jegga AG, Kong S, Sakthivel B, Xu H, Reichling T, Azhar M, et al. Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer. Genome Biology. 8: R131. PMID 17615082 DOI: 10.1186/Gb-2007-8-7-R131 |
0.628 |
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| 2007 |
Keller JW, Haigis KM, Franklin JL, Whitehead RH, Jacks T, Coffey RJ. Oncogenic K-RAS subverts the antiapoptotic role of N-RAS and alters modulation of the N-RAS:gelsolin complex. Oncogene. 26: 3051-9. PMID 17130841 DOI: 10.1038/Sj.Onc.1210103 |
0.651 |
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| 2007 |
Li Q, Haigis K, McDaniel A, Huang B, Miller M, Shieh A, Kogan S, Wolff L, Jacks T, Shannon K. Expressing N-RasG12D from the Endogenous Promoter Induces Myeloproliferative Disease (MPD) and Cooperates with Retroviral Insertional Mutagenesis (RIM) To Generate Acute Myeloid Leukemia (AML). Blood. 110: 1616-1616. DOI: 10.1182/Blood.V110.11.1616.1616 |
0.663 |
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| 2006 |
Haigis K, Sage J, Glickman J, Shafer S, Jacks T. The related retinoblastoma (pRb) and p130 proteins cooperate to regulate homeostasis in the intestinal epithelium. The Journal of Biological Chemistry. 281: 638-47. PMID 16258171 DOI: 10.1074/Jbc.M509053200 |
0.709 |
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| 2006 |
Kirsch D, Santiago P, Haigis K, di Tomaso E, Takeuchi O, Korsmeyer S, Bronson R, Jain R, Jacks T. 2685 International Journal of Radiation Oncology*Biology*Physics. 66: S590. DOI: 10.1016/J.Ijrobp.2006.07.1100 |
0.581 |
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| 2005 |
Kirsch D, Haigis K, Santiago P, Tukeshia O, Korsmeyer S, Jacks T. Using Mouse Genetics to Dissect the Cellular Target of Radiation in the GI Syndrome International Journal of Radiation Oncology*Biology*Physics. 63: S469. DOI: 10.1016/J.Ijrobp.2005.07.797 |
0.575 |
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| 2004 |
Haigis KM, Hoff PD, White A, Shoemaker AR, Halberg RB, Dove WF. Tumor regionality in the mouse intestine reflects the mechanism of loss of Apc function. Proceedings of the National Academy of Sciences of the United States of America. 101: 9769-73. PMID 15210940 DOI: 10.1073/Pnas.0403338101 |
0.623 |
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| 2003 |
Haigis KM, Dove WF. A Robertsonian translocation suppresses a somatic recombination pathway to loss of heterozygosity. Nature Genetics. 33: 33-9. PMID 12447373 DOI: 10.1038/Ng1055 |
0.624 |
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| 2002 |
Haigis KM, Caya JG, Reichelderfer M, Dove WF. Intestinal adenomas can develop with a stable karyotype and stable microsatellites. Proceedings of the National Academy of Sciences of the United States of America. 99: 8927-31. PMID 12060718 DOI: 10.1073/Pnas.132275099 |
0.618 |
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| 2000 |
Shoemaker AR, Haigis KM, Baker SM, Dudley S, Liskay RM, Dove WF. Mlh1 deficiency enhances several phenotypes of Apc(Min)/+ mice. Oncogene. 19: 2774-9. PMID 10851078 DOI: 10.1038/Sj.Onc.1203574 |
0.642 |
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| Low-probability matches (unlikely to be authored by this person) |
| 2019 |
Brubaker DK, Proctor EA, Haigis KM, Lauffenburger DA. Computational translation of genomic responses from experimental model systems to humans. Plos Computational Biology. 15: e1006286. PMID 30629591 DOI: 10.1371/Journal.Pcbi.1006286 |
0.298 |
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| 2012 |
Mitra D, Luo X, Morgan A, Wang J, Hoang MP, Lo J, Guerrero CR, Lennerz JK, Mihm MC, Wargo JA, Robinson KC, Devi SP, Vanover JC, D'Orazio JA, McMahon M, ... ... Haigis KM, et al. An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background. Nature. 491: 449-53. PMID 23123854 DOI: 10.1038/Nature11624 |
0.293 |
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| 2009 |
Matharu KS, Mizoguchi E, Cotoner CA, Nguyen DD, Mingle B, Iweala OI, McBee ME, Stefka AT, Prioult G, Haigis KM, Bhan AK, Snapper SB, Murakami H, Schauer DB, Reinecker HC, et al. Toll-Like Receptor 4-Mediated Regulation of Spontaneous Helicobacter-Dependent Colitis in IL-10-Deficient Mice Gastroenterology. 137: 1380-1390.e3. PMID 19596011 DOI: 10.1053/J.Gastro.2009.07.004 |
0.29 |
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| 2020 |
Knight JRP, Alexandrou C, Skalka GL, Vlahov N, Pennel K, Officer L, Teodosio A, Kanellos G, Gay DM, May-Wilson S, Smith EM, Najumudeen AK, Gilroy K, Ridgway RA, Flanagan DJ, ... ... Haigis KM, et al. MNK inhibition sensitizes KRAS-mutant colorectal cancer to mTORC1 inhibition by reducing eIF4E phosphorylation and c-MYC expression. Cancer Discovery. PMID 33328217 DOI: 10.1158/2159-8290.CD-20-0652 |
0.284 |
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| 2008 |
Morris EJ, Ji JY, Yang F, Di Stefano L, Herr A, Moon NS, Kwon EJ, Haigis KM, Näär AM, Dyson NJ. E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8. Nature. 455: 552-6. PMID 18794899 DOI: 10.1038/Nature07310 |
0.283 |
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| 2013 |
Miraldi ER, Sharfi H, Friedline RH, Johnson H, Zhang T, Lau KS, Ko HJ, Curran TG, Haigis KM, Yaffe MB, Bonneau R, Lauffenburger DA, Kahn BB, Kim JK, Neel BG, et al. Molecular network analysis of phosphotyrosine and lipid metabolism in hepatic PTP1b deletion mice. Integrative Biology : Quantitative Biosciences From Nano to Macro. 5: 940-63. PMID 23685806 DOI: 10.1039/C3Ib40013A |
0.281 |
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| 2015 |
Gierut JJ, Wood LB, Lau KS, Lin YJ, Genetti C, Samatar AA, Lauffenburger DA, Haigis KM. Network-level effects of kinase inhibitors modulate TNF-α-induced apoptosis in the intestinal epithelium. Science Signaling. 8: ra129. PMID 26671150 DOI: 10.1126/Scisignal.Aac7235 |
0.28 |
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| 2019 |
Strasser SD, Ghazi PC, Starchenko A, Boukhali M, Edwards A, Suarez-Lopez L, Lyons J, Changelian PS, Monahan JB, Jacobsen J, Brubaker DK, Joughin BA, Yaffe MB, Haas W, Lauffenburger DA, ... Haigis KM, et al. Substrate-based kinase activity inference identifies MK2 as driver of colitis. Integrative Biology : Quantitative Biosciences From Nano to Macro. PMID 31617572 DOI: 10.1093/Intbio/Zyz025 |
0.279 |
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| 2009 |
Matharu KS, Mizoguchi E, Cotoner CA, Nguyen DD, Mingle B, Iweala OI, McBee ME, Stefka A, Prioult G, Haigis K, Bhan AK, Snapper SB, Murakami H, Schauer D, Reinecker H, et al. W1627 TLR4 Mediated Regulation of Spontaneous Colitis in IL-10 Deficient Mice Gastroenterology. 136: A-705. DOI: 10.1016/S0016-5085(09)63251-0 |
0.275 |
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| 2006 |
Haigis MC, Mostoslavsky R, Haigis KM, Fahie K, Christodoulou DC, Murphy AJ, Valenzuela DM, Yancopoulos GD, Karow M, Blander G, Wolberger C, Prolla TA, Weindruch R, Alt FW, Guarente L. SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell. 126: 941-54. PMID 16959573 DOI: 10.1016/J.Cell.2006.06.057 |
0.274 |
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| 2010 |
Li Y, Franklin J, Wang Y, Haigis K, Coffey RJ. 783 Lrig1, a Cell Surface Pan-ERBB Inhibitor, Marks Colonic Stem Cells Gastroenterology. 138: S-110. DOI: 10.1016/S0016-5085(10)60504-5 |
0.269 |
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| 2007 |
Haigis KM, Wistuba II, Kurie JM. Lung premalignancy induced by mutant B-Raf, what is thy fate? To senesce or not to senesce, that is the question. Genes & Development. 21: 361-6. PMID 17322395 DOI: 10.1101/Gad.1532107 |
0.266 |
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| 2020 |
Li X, Pritykin Y, Concepcion CP, Lu Y, La Rocca G, Zhang M, King B, Cook PJ, Au YW, Popow O, Paulo JA, Otis HG, Mastroleo C, Ogrodowski P, Schreiner R, ... Haigis KM, et al. High-Resolution In Vivo Identification of miRNA Targets by Halo-Enhanced Ago2 Pull-Down. Molecular Cell. PMID 32497496 DOI: 10.1016/J.Molcel.2020.05.009 |
0.265 |
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| 2017 |
Zambetti NA, Firestone AJ, Wong JC, Long A, Inguva A, Suciu RM, Cravatt BF, Haigis KM, Shannon KM. Genetic Validation of the Palmitoylation/Depalmitoylation Cycle As a Drug Target in NRAS Mutant Hematologic Malignancies In Vivo Blood. 130: 1221-1221. DOI: 10.1182/Blood.V130.Suppl_1.1221.1221 |
0.264 |
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| 2019 |
Brubaker D, Haigis KM, Lauffenburger DA. P113 COMPARATIVE TRANSCRIPTOMIC ANALYSIS OF IBD MOUSE MODELS AND PATIENT COHORTS FOR INTERSPECIES TRANSLATION Gastroenterology. 156: S78. DOI: 10.1053/J.Gastro.2019.01.179 |
0.264 |
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| 2021 |
Cook JH, Melloni GEM, Gulhan DC, Park PJ, Haigis KM. The origins and genetic interactions of KRAS mutations are allele- and tissue-specific. Nature Communications. 12: 1808. PMID 33753749 DOI: 10.1038/s41467-021-22125-z |
0.259 |
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| 2020 |
Suarez-Lopez L, Kong YW, Sriram G, Patterson JC, Rosenberg S, Morandell S, Haigis KM, Yaffe MB. MAPKAP Kinase-2 Drives Expression of Angiogenic Factors by Tumor-Associated Macrophages in a Model of Inflammation-Induced Colon Cancer. Frontiers in Immunology. 11: 607891. PMID 33708191 DOI: 10.3389/fimmu.2020.607891 |
0.254 |
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| 2015 |
Wood LB, Winslow AR, Proctor EA, McGuone D, Mordes DA, Frosch MP, Hyman BT, Lauffenburger DA, Haigis KM. Identification of neurotoxic cytokines by profiling Alzheimer's disease tissues and neuron culture viability screening. Scientific Reports. 5: 16622. PMID 26564777 DOI: 10.1038/Srep16622 |
0.251 |
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| 2022 |
Johnson CW, Seo HS, Terrell EM, Yang MH, KleinJan F, Gebregiworgis T, Gasmi-Seabrook GMC, Geffken EA, Lakhani J, Song K, Bashyal P, Popow O, Paulo JA, Liu A, Mattos C, ... ... Haigis KM, et al. Regulation of GTPase function by autophosphorylation. Molecular Cell. PMID 35202574 DOI: 10.1016/j.molcel.2022.02.011 |
0.24 |
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| 2016 |
Deshpande V, Konstantinidis IT, Castillo CF, Hezel AF, Haigis KM, Ting DT, Bardeesy N, Goyal L, Zhu AX, Warshaw AL, Lillemoe KD, Ferrone CR. Intra-pancreatic Distal Bile Duct Carcinoma is Morphologically, Genetically, and Clinically Distinct from Pancreatic Ductal Adenocarcinoma. Journal of Gastrointestinal Surgery : Official Journal of the Society For Surgery of the Alimentary Tract. 20: 953-9. PMID 26956004 DOI: 10.1007/S11605-016-3108-0 |
0.233 |
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| 2013 |
Cho H, Hashimoto T, Wong E, Hori Y, Wood LB, Zhao L, Haigis KM, Hyman BT, Irimia D. Microfluidic chemotaxis platform for differentiating the roles of soluble and bound amyloid-β on microglial accumulation. Scientific Reports. 3: 1823. PMID 23665843 DOI: 10.1038/Srep01823 |
0.232 |
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| 2023 |
Grabski IN, Heymach JV, Kehl KL, Kopetz S, Lau KS, Riely GJ, Schrag D, Yaeger R, Irizarry RA, Haigis KM. Effects of KRAS genetic interactions on outcomes in cancers of the lung, pancreas, and colorectum. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. PMID 37943166 DOI: 10.1158/1055-9965.EPI-23-0262 |
0.23 |
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| 2023 |
Shui B, Beyett TS, Chen Z, Li X, La Rocca G, Gazlay WM, Eck MJ, Lau KS, Ventura A, Haigis KM. Oncogenic K-Ras suppresses global miRNA function. Molecular Cell. PMID 37402366 DOI: 10.1016/j.molcel.2023.06.008 |
0.223 |
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| 2022 |
Shui B, La Rocca G, Ventura A, Haigis KM. Interplay between K-RAS and miRNAs. Trends in Cancer. PMID 35093302 DOI: 10.1016/j.trecan.2022.01.002 |
0.216 |
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| 1995 |
Davis TM, Yu H, Haigis KM, McGowan PJ. Template mixing: a method of enhancing detection and interpretation of codominant RAPD markers Theoretical and Applied Genetics. 91: 582-588. DOI: 10.1007/Bf00223283 |
0.203 |
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| 2016 |
Baldwin KR, Lyons J, Wood L, Yajnik V, Haigis K. Sa1857 New Targets of Interest: MIP-1a and MIP-1b in Crohn's Disease Gastroenterology. 150: S382-S383. DOI: 10.1016/S0016-5085(16)31346-4 |
0.201 |
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| 2024 |
Tucker SA, Hu SH, Vyas S, Park A, Joshi S, Inal A, Lam T, Tan E, Haigis KM, Haigis MC. SIRT4 loss reprograms intestinal nucleotide metabolism to support proliferation following perturbation of homeostasis. Cell Reports. 43: 113975. PMID 38507411 DOI: 10.1016/j.celrep.2024.113975 |
0.193 |
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| 2024 |
Gillani R, Collins RL, Crowdis J, Garza A, Jones JK, Walker M, Sanchis-Juan A, Whelan C, Pierce-Hoffman E, Talkowski M, Brand H, Haigis K, LoPiccolo J, AlDubayan SH, Gusev A, et al. Rare germline structural variants increase risk for pediatric solid tumors. Biorxiv : the Preprint Server For Biology. PMID 38746320 DOI: 10.1101/2024.04.27.591484 |
0.189 |
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| 2023 |
Johnson CW, Haigis KM. All Roads Lead to Rome: YAP/TAZ Activity Influences Efficacy of KRASG12C Inhibitors. Cancer Research. 83: 4005-4007. PMID 38098448 DOI: 10.1158/0008-5472.CAN-23-3547 |
0.163 |
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| 2019 |
Brubaker DK, Proctor EA, Haigis KM, Lauffenburger DA. Computational translation of genomic responses from experimental model systems to humans. Plos Computational Biology. 15: e1006286. PMID 30629591 DOI: 10.1371/journal.pcbi.1006286 |
0.162 |
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| 2021 |
Awad MM, Liu S, Rybkin II, Arbour KC, Dilly J, Zhu VW, Johnson ML, Heist RS, Patil T, Riely GJ, Jacobson JO, Yang X, Persky NS, Root DE, Lowder KE, ... ... Haigis KM, et al. Acquired Resistance to KRAS Inhibition in Cancer. The New England Journal of Medicine. 384: 2382-2393. PMID 34161704 DOI: 10.1056/NEJMoa2105281 |
0.152 |
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| 2021 |
Suarez-Lopez L, Shui B, Brubaker DK, Hill M, Bergendorf A, Changelian PS, Laguna A, Starchenko A, Lauffenburger DA, Haigis KM. Cross-species transcriptomic signatures predict response to MK2 inhibition in mouse models of chronic inflammation. Iscience. 24: 103406. PMID 34849469 DOI: 10.1016/j.isci.2021.103406 |
0.136 |
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| 2021 |
Martin TD, Patel RS, Cook DR, Choi MY, Patil A, Liang AC, Li MZ, Haigis KM, Elledge SJ. The adaptive immune system is a major driver of selection for tumor suppressor gene inactivation. Science (New York, N.Y.). 373: 1327-1335. PMID 34529489 DOI: 10.1126/science.abg5784 |
0.134 |
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| 2012 |
Lau KS, Cortez-Retamozo V, Philips SR, Pittet MJ, Lauffenburger DA, Haigis KM. Correction: Multi-Scale In Vivo Systems Analysis Reveals the Influence of Immune Cells on TNF-α-Induced Apoptosis in the Intestinal Epithelium Plos Biology. 10. DOI: 10.1371/annotation/60833838-f1b9-4f9c-ae0b-485c4acd09c1 |
0.112 |
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| 2021 |
La Rocca G, King B, Shui B, Li X, Zhang M, Akat K, Ogrodowski P, Mastroleo C, Chen K, Cavalieri V, Ma Y, Anelli V, Betel D, Vidigal J, Tuschl T, ... ... Haigis K, et al. Inducible and reversible inhibition of miRNA-mediated gene repression . Elife. 10. PMID 34463618 DOI: 10.7554/eLife.70948 |
0.084 |
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| 2021 |
Popow O, Liu X, Haigis KM, Gygi SP, Paulo JA. A Compendium of Murine (Phospho)Peptides Encompassing Different Isobaric Labeling and Data Acquisition Strategies. Journal of Proteome Research. PMID 34043369 DOI: 10.1021/acs.jproteome.1c00247 |
0.071 |
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| 2015 |
Nicolay BN, Danielian PS, Kottakis F, Lapek JD, Sanidas I, Miles WO, Dehnad M, Tschöp K, Gierut JJ, Manning AL, Morris R, Haigis K, Bardeesy N, Lees JA, Haas W, et al. Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation Genes and Development. 29: 1875-1889. DOI: 10.1101/gad.264127.115 |
0.05 |
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| Hide low-probability matches. |