Kim Orth - Publications

Affiliations: 
University of Texas Southwestern, Dallas, TX, United States 

99 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Gulen B, Casey A, Orth K. AMPylation of small GTPases by Fic enzymes. Febs Letters. PMID 36239538 DOI: 10.1002/1873-3468.14516  0.359
2022 Lafrance AE, Chimalapati S, Garcia Rodriguez N, Kinch LN, Kaval KG, Orth K. Enzymatic Specificity of Conserved Rho GTPase Deamidases Promotes Invasion of Vibrio parahaemolyticus at the Expense of Infection. Mbio. e0162922. PMID 35862776 DOI: 10.1128/mbio.01629-22  0.358
2021 Ebrahimzadeh T, Kuprasertkul A, Neugent ML, Lutz KC, Fuentes JL, Gadhvi J, Khan F, Zhang C, Sharon BM, Orth K, Li Q, Zimmern PE, De Nisco NJ. Urinary prostaglandin E2 as a biomarker for recurrent UTI in postmenopausal women. Life Science Alliance. 4. PMID 33958485 DOI: 10.26508/lsa.202000948  0.621
2021 Fernandez J, Lopez V, Kinch L, Pfeifer MA, Gray H, Garcia N, Grishin NV, Khang CH, Orth K. Role of Two Metacaspases in Development and Pathogenicity of the Rice Blast Fungus Magnaporthe oryzae. Mbio. 12. PMID 33563831 DOI: 10.1128/mBio.03471-20  0.327
2021 De Nisco NJ, Casey AK, Kanchwala M, Lafrance AE, Coskun FS, Kinch LN, Grishin NV, Xing C, Orth K. Manipulation of IRE1-Dependent MAPK Signaling by a Vibrio Agonist-Antagonist Effector Pair. Msystems. 6. PMID 33563785 DOI: 10.1128/mSystems.00872-20  0.73
2020 Chimalapati S, de Souza Santos M, Lafrance AE, Ray A, Lee WR, Rivera-Cancel G, Vale G, Pawlowski K, Mitsche MA, McDonald JG, Liou J, Orth K. Vibrio deploys type 2 secreted lipase to esterify cholesterol with host fatty acids and mediate cell egress. Elife. 9. PMID 32808593 DOI: 10.7554/Elife.58057  0.417
2020 Huebinger RM, Do DH, Carlson DL, Yao X, Stones DH, De Souza Santos M, Vaz DP, Keen E, Wolf SE, Minei JP, Francis KP, Orth K, Krachler AM. Bacterial adhesion inhibitor prevents infection in a rodent surgical incision model. Virulence. 11: 695-706. PMID 32490711 DOI: 10.1080/21505594.2020.1772652  0.345
2020 Peng W, Casey AK, Fernandez J, Carpinone EM, Servage KA, Chen Z, Li Y, Tomchick DR, Starai VJ, Orth K. A distinct inhibitory mechanism of the V-ATPase by Vibrio VopQ revealed by cryo-EM. Nature Structural & Molecular Biology. PMID 32424347 DOI: 10.1038/S41594-020-0429-1  0.41
2020 Servage KA, Stefanius K, Gray HF, Orth K. Proteomic Profiling of Small Extracellular Vesicles Secreted by Human Pancreatic Cancer Cells Implicated in Cellular Transformation. Scientific Reports. 10: 7713. PMID 32382024 DOI: 10.1038/S41598-020-64718-6  0.339
2020 D'Souza RS, Lim JY, Turgut A, Servage K, Zhang J, Orth K, Sosale N, Lazzara M, Allegood J, Casanova JE. Calcium-stimulated disassembly of focal adhesions mediated by an ORP3/IQSec1 complex. Elife. 9. PMID 32234213 DOI: 10.7554/Elife.54113  0.319
2020 Chimalapati S, Santos MdS, Lafrance AE, Ray A, Lee W, Rivera-Cancel G, Vale G, Pawlowski K, Mitsche MA, McDonald JG, Liou J, Orth K. Author response: Vibrio deploys type 2 secreted lipase to esterify cholesterol with host fatty acids and mediate cell egress Elife. DOI: 10.7554/Elife.58057.Sa2  0.32
2019 Yang H, de Souza Santos M, Lee J, Law HT, Chimalapati S, Verdu EF, Orth K, Vallance BA. A Novel Mouse Model of Enteric Vibrio parahaemolyticus Infection Reveals that the Type III Secretion System 2 Effector VopC Plays a Key Role in Tissue Invasion and Gastroenteritis. Mbio. 10. PMID 31848276 DOI: 10.1128/Mbio.02608-19  0.42
2019 Bhargava V, Goldstein CD, Russell L, Xu L, Ahmed M, Li W, Casey A, Servage K, Kollipara R, Picciarelli Z, Kittler R, Yatsenko A, Carmell M, Orth K, Amatruda JF, et al. GCNA Preserves Genome Integrity and Fertility Across Species. Developmental Cell. PMID 31839537 DOI: 10.1016/J.Devcel.2019.11.007  0.331
2019 De Souza Santos M, Orth K. The Role of the Type III Secretion System in the Intracellular Lifestyle of Enteric Pathogens. Microbiology Spectrum. 7. PMID 31152523 DOI: 10.1128/microbiolspec.BAI-0008-2019  0.355
2019 Peng W, de Souza Santos M, Li Y, Tomchick DR, Orth K. High-resolution cryo-EM structures of the E. coli hemolysin ClyA oligomers. Plos One. 14: e0213423. PMID 31048915 DOI: 10.1371/Journal.Pone.0213423  0.327
2019 De Nisco NJ, Neugent M, Mull J, Chen L, Kuprasertkul A, de Souza Santos M, Palmer KL, Zimmern P, Orth K. Direct Detection of Tissue-Resident Bacteria and Chronic Inflammation in the Bladder Wall of Postmenopausal Women with Recurrent Urinary Tract Infection. Journal of Molecular Biology. PMID 31002774 DOI: 10.1016/j.jmb.2019.04.008  0.661
2019 Tomchick DR, Sreelatha A, Yee SS, Lopez VA, Park BC, Kinch LN, Pilch S, Servage KA, Zhang J, Jiou J, Karasiewicz-Urbańska M, Łobocka M, Grishin NV, Orth K, Kucharczyk R, et al. Protein AMPylation by an evolutionarily conserved pseudokinase Acta Crystallographica Section A. 75. DOI: 10.1107/S0108767319096922  0.747
2018 Sreelatha A, Yee SS, Lopez VA, Park BC, Kinch LN, Pilch S, Servage KA, Zhang J, Jiou J, Karasiewicz-Urbańska M, Łobocka M, Grishin NV, Orth K, Kucharczyk R, Pawłowski K, et al. Protein AMPylation by an Evolutionarily Conserved Pseudokinase. Cell. PMID 30270044 DOI: 10.1016/J.Cell.2018.08.046  0.764
2018 Chimalapati S, de Souza Santos M, Servage K, De Nisco NJ, Dalia AB, Orth K. Natural transformation of: A rapid method to create genetic deletions. Journal of Bacteriology. PMID 29555695 DOI: 10.1128/Jb.00032-18  0.637
2018 Casey AK, Moehlman AT, Zhang J, Servage KA, Krämer H, Orth K. Fic-mediated deAMPylation is not dependent on homodimerization and rescues toxic AMPylation in flies. The Journal of Biological Chemistry. 293: 1550. PMID 29414767 DOI: 10.1074/Jbc.Aac118.001798  0.335
2018 Fernandez J, Orth K. Rise of a Cereal Killer: The Biology of Magnaporthe oryzae Biotrophic Growth. Trends in Microbiology. PMID 29395728 DOI: 10.1016/J.Tim.2017.12.007  0.379
2018 De Nisco NJ, Rivera-Cancel G, Orth K. The Biochemistry of Sensing: Enteric Pathogens Regulate Type III Secretion in Response to Environmental and Host Cues. Mbio. 9. PMID 29339429 DOI: 10.1128/Mbio.02122-17  0.711
2017 Ray A, Schwartz N, de Souza Santos M, Zhang J, Orth K, Salomon D. Type VI secretion system MIX-effectors carry both antibacterial and anti-eukaryotic activities. Embo Reports. PMID 28912123 DOI: 10.15252/Embr.201744226  0.417
2017 Casey AK, Orth K. Enzymes Involved in AMPylation and deAMPylation. Chemical Reviews. PMID 28819965 DOI: 10.1021/Acs.Chemrev.7B00145  0.37
2017 De Nisco NJ, Orth K, VanHook AM. Science Signaling Podcast for 16 May 2017: Vibrio rewires host cells. Science Signaling. 10. PMID 28512146 DOI: 10.1126/Scisignal.Aan5621  0.724
2017 De Nisco NJ, Kanchwala M, Li P, Fernandez J, Xing C, Orth K. The cytotoxic type 3 secretion system 1 of Vibrio rewires host gene expression to subvert cell death and activate cell survival pathways. Science Signaling. 10. PMID 28512145 DOI: 10.1126/Scisignal.Aal4501  0.735
2017 Li P, Kinch LN, Ray A, Dalia AB, Cong Q, Nunan LM, Camilli A, Grishin NV, Salomon D, Orth K. Acute Hepatopancreatic Necrosis Disease (AHPND)-causing Vibrio parahaemolyticus strains maintain an antibacterial Type VI Secretion System with versatile effector repertoires. Applied and Environmental Microbiology. PMID 28432099 DOI: 10.1128/Aem.00737-17  0.335
2017 Rivera-Cancel G, Orth K. Biochemical basis for activation of virulence genes by bile salts in Vibrio parahaemolyticus. Gut Microbes. 1-8. PMID 28129014 DOI: 10.1080/19490976.2017.1287655  0.312
2016 Ray A, Kinch LN, de Souza Santos M, Grishin NV, Orth K, Salomon D. Proteomics Analysis Reveals Previously Uncharacterized Virulence Factors in Vibrio proteolyticus. Mbio. 7. PMID 27460800 DOI: 10.1128/Mbio.01077-16  0.423
2016 Li P, Rivera-Cancel G, Kinch LN, Salomon D, Tomchick DR, Grishin NV, Orth K. Bile salt receptor complex activates a pathogenic type III secretion system. Elife. 5. PMID 27377244 DOI: 10.7554/Elife.15718  0.384
2015 Salomon D, Klimko JA, Trudgian DC, Kinch LN, Grishin NV, Mirzaei H, Orth K. Type VI Secretion System Toxins Horizontally Shared between Marine Bacteria. Plos Pathogens. 11: e1005128. PMID 26305100 DOI: 10.1371/Journal.Ppat.1005128  0.438
2015 Sreelatha A, Bennett TL, Carpinone EM, O'Brien KM, Jordan KD, Burdette DL, Orth K, Starai VJ. Vibrio effector protein VopQ inhibits fusion of V-ATPase-containing membranes. Proceedings of the National Academy of Sciences of the United States of America. 112: 100-5. PMID 25453092 DOI: 10.1073/Pnas.1413764111  0.75
2015 de Souza Santos M, Orth K. Subversion of the cytoskeleton by intracellular bacteria: lessons from Listeria, Salmonella and Vibrio. Cellular Microbiology. 17: 164-73. PMID 25440316 DOI: 10.1111/Cmi.12399  0.43
2014 Woolery AR, Yu X, LaBaer J, Orth K. AMPylation of Rho GTPases subverts multiple host signaling processes. The Journal of Biological Chemistry. 289: 32977-88. PMID 25301945 DOI: 10.1074/Jbc.M114.601310  0.476
2014 de Souza Santos M, Orth K. Intracellular Vibrio parahaemolyticus escapes the vacuole and establishes a replicative niche in the cytosol of epithelial cells. Mbio. 5: e01506-14. PMID 25205094 DOI: 10.1128/mBio.01506-14  0.374
2014 Calder T, Kinch LN, Fernandez J, Salomon D, Grishin NV, Orth K. Vibrio type III effector VPA1380 is related to the cysteine protease domain of large bacterial toxins. Plos One. 9: e104387. PMID 25099122 DOI: 10.1371/Journal.Pone.0104387  0.451
2014 Yu X, Woolery AR, Luong P, Hao YH, Grammel M, Westcott N, Park J, Wang J, Bian X, Demirkan G, Hang HC, Orth K, LaBaer J. Copper-catalyzed azide-alkyne cycloaddition (click chemistry)-based detection of global pathogen-host AMPylation on self-assembled human protein microarrays. Molecular & Cellular Proteomics : McP. 13: 3164-76. PMID 25073739 DOI: 10.1074/Mcp.M114.041103  0.367
2014 Salomon D, Kinch LN, Trudgian DC, Guo X, Klimko JA, Grishin NV, Mirzaei H, Orth K. Marker for type VI secretion system effectors. Proceedings of the National Academy of Sciences of the United States of America. 111: 9271-6. PMID 24927539 DOI: 10.1073/Pnas.1406110111  0.353
2014 Lewallen DM, Sreelatha A, Dharmarajan V, Madoux F, Chase P, Griffin PR, Orth K, Hodder P, Thompson PR. Inhibiting AMPylation: a novel screen to identify the first small molecule inhibitors of protein AMPylation. Acs Chemical Biology. 9: 433-42. PMID 24274060 DOI: 10.1021/Cb4006886  0.779
2013 Salomon D, Guo Y, Kinch LN, Grishin NV, Gardner KH, Orth K. Effectors of animal and plant pathogens use a common domain to bind host phosphoinositides. Nature Communications. 4: 2973. PMID 24346350 DOI: 10.1038/Ncomms3973  0.325
2013 Hawley CA, Watson CA, Orth K, Krachler AM. A MAM7 peptide-based inhibitor of Staphylococcus aureus adhesion does not interfere with in vitro host cell function. Plos One. 8: e81216. PMID 24265842 DOI: 10.1371/Journal.Pone.0081216  0.401
2013 Sreelatha A, Orth K, Starai VJ. The pore-forming bacterial effector, VopQ, halts autophagic turnover. Autophagy. 9: 2169-70. PMID 24145145 DOI: 10.4161/Auto.26449  0.779
2013 Salomon D, Orth K. What pathogens have taught us about posttranslational modifications. Cell Host & Microbe. 14: 269-79. PMID 24034613 DOI: 10.1016/J.Chom.2013.07.008  0.46
2013 Altura MA, Heath-Heckman EA, Gillette A, Kremer N, Krachler AM, Brennan C, Ruby EG, Orth K, McFall-Ngai MJ. The first engagement of partners in the Euprymna scolopes-Vibrio fischeri symbiosis is a two-step process initiated by a few environmental symbiont cells. Environmental Microbiology. 15: 2937-50. PMID 23819708 DOI: 10.1111/1462-2920.12179  0.398
2013 Krachler AM, Orth K. Targeting the bacteria-host interface: strategies in anti-adhesion therapy. Virulence. 4: 284-94. PMID 23799663 DOI: 10.4161/Viru.24606  0.392
2013 Sreelatha A, Bennett TL, Zheng H, Jiang QX, Orth K, Starai VJ. Vibrio effector protein, VopQ, forms a lysosomal gated channel that disrupts host ion homeostasis and autophagic flux. Proceedings of the National Academy of Sciences of the United States of America. 110: 11559-64. PMID 23798441 DOI: 10.1073/Pnas.1307032110  0.781
2013 Salomon D, Gonzalez H, Updegraff BL, Orth K. Vibrio parahaemolyticus type VI secretion system 1 is activated in marine conditions to target bacteria, and is differentially regulated from system 2. Plos One. 8: e61086. PMID 23613791 DOI: 10.1371/Journal.Pone.0061086  0.379
2013 Salomon D, Orth K. Lost after translation: post-translational modifications by bacterial type III effectors. Current Opinion in Microbiology. 16: 213-20. PMID 23466212 DOI: 10.1016/J.Mib.2013.01.013  0.462
2013 Zhang L, Orth K. Virulence determinants for Vibrio parahaemolyticus infection. Current Opinion in Microbiology. 16: 70-7. PMID 23433802 DOI: 10.1016/J.Mib.2013.02.002  0.426
2013 Krachler A, Orth K. Made to Stick: Anti-Adhesion Therapy for Bacterial Infections Microbe Magazine. 8: 286-290. DOI: 10.1128/Microbe.8.286.1  0.328
2012 Ham H, Orth K. The role of type III secretion System 2 in Vibrio parahaemolyticus pathogenicity Journal of Microbiology. 50: 719-725. PMID 23124738 DOI: 10.1007/s12275-012-2550-2  0.36
2012 Alto NM, Orth K. Subversion of cell signaling by pathogens. Cold Spring Harbor Perspectives in Biology. 4: a006114. PMID 22952390 DOI: 10.1101/Cshperspect.A006114  0.431
2012 Zhang L, Krachler AM, Broberg CA, Li Y, Mirzaei H, Gilpin CJ, Orth K. Type III effector VopC mediates invasion for Vibrio species. Cell Reports. 1: 453-60. PMID 22787576 DOI: 10.1016/J.Celrep.2012.04.004  0.443
2012 Krachler AM, Ham H, Orth K. Turnabout is fair play: use of the bacterial Multivalent Adhesion Molecule 7 as an antimicrobial agent. Virulence. 3: 68-71. PMID 22086133 DOI: 10.4161/Viru.3.1.18172  0.431
2011 Krachler AM, Woolery AR, Orth K. Manipulation of kinase signaling by bacterial pathogens. The Journal of Cell Biology. 195: 1083-92. PMID 22123833 DOI: 10.1083/Jcb.201107132  0.444
2011 Ham H, Orth K. De-AMPylation unmasked: Modulation of host membrane trafficking Science Signaling. 4. PMID 21990428 DOI: 10.1126/Scisignal.2002458  0.508
2011 Grammel M, Luong P, Orth K, Hang HC. A chemical reporter for protein AMPylation. Journal of the American Chemical Society. 133: 17103-5. PMID 21942216 DOI: 10.1021/Ja205137D  0.38
2011 Krachler AM, Orth K. Functional characterization of the interaction between bacterial adhesin multivalent adhesion molecule 7 (MAM7) protein and its host cell ligands. The Journal of Biological Chemistry. 286: 38939-47. PMID 21937438 DOI: 10.1074/jbc.M111.291377  0.306
2011 Broberg CA, Calder TJ, Orth K. Vibrio parahaemolyticus cell biology and pathogenicity determinants. Microbes and Infection. 13: 992-1001. PMID 21782964 DOI: 10.1016/J.Micinf.2011.06.013  0.391
2011 Ham H, Sreelatha A, Orth K. Manipulation of host membranes by bacterial effectors Nature Reviews Microbiology. 9: 635-646. PMID 21765451 DOI: 10.1038/Nrmicro2602  0.778
2011 Krachler AM, Ham H, Orth K. Outer membrane adhesion factor multivalent adhesion molecule 7 initiates host cell binding during infection by gram-negative pathogens. Proceedings of the National Academy of Sciences of the United States of America. 108: 11614-9. PMID 21709226 DOI: 10.1073/pnas.1102360108  0.358
2010 Broberg CA, Zhang L, Gonzalez H, Laskowski-Arce MA, Orth K. A Vibrio effector protein is an inositol phosphatase and disrupts host cell membrane integrity. Science (New York, N.Y.). 329: 1660-2. PMID 20724587 DOI: 10.1126/Science.1192850  0.459
2010 Luong P, Kinch LN, Brautigam CA, Grishin NV, Tomchick DR, Orth K. Kinetic and structural insights into the mechanism of AMPylation by VopS Fic domain. The Journal of Biological Chemistry. 285: 20155-63. PMID 20410310 DOI: 10.1074/Jbc.M110.114884  0.302
2010 Broberg CA, Orth K. Tipping the balance by manipulating post-translational modifications. Current Opinion in Microbiology. 13: 34-40. PMID 20071215 DOI: 10.1016/j.mib.2009.12.004  0.324
2009 Burdette DL, Seemann J, Orth K. Vibrio VopQ induces PI3-kinase-independent autophagy and antagonizes phagocytosis. Molecular Microbiology. 73: 639-49. PMID 19627496 DOI: 10.1111/J.1365-2958.2009.06798.X  0.755
2009 Yarbrough ML, Orth K. AMPylation is a new post-translational modiFICation. Nature Chemical Biology. 5: 378-9. PMID 19448605 DOI: 10.1038/Nchembio0609-378  0.356
2009 Yarbrough ML, Li Y, Kinch LN, Grishin NV, Ball HL, Orth K. AMPylation of Rho GTPases by Vibrio VopS disrupts effector binding and downstream signaling. Science (New York, N.Y.). 323: 269-72. PMID 19039103 DOI: 10.1126/Science.1166382  0.457
2009 Burdette DL, Yarbrough ML, Orth K. Not without cause: Vibrio parahaemolyticus induces acute autophagy and cell death. Autophagy. 5: 100-2. PMID 19011375 DOI: 10.4161/Auto.5.1.7264  0.748
2008 Laskowski-Arce MA, Orth K. Acanthamoeba castellanii promotes the survival of Vibrio parahaemolyticus. Applied and Environmental Microbiology. 74: 7183-8. PMID 18849458 DOI: 10.1128/Aem.01332-08  0.322
2008 Burdette DL, Yarbrough ML, Orvedahl A, Gilpin CJ, Orth K. Vibrio parahaemolyticus orchestrates a multifaceted host cell infection by induction of autophagy, cell rounding, and then cell lysis. Proceedings of the National Academy of Sciences of the United States of America. 105: 12497-502. PMID 18713860 DOI: 10.1073/Pnas.0802773105  0.763
2008 Le Negrate G, Faustin B, Welsh K, Loeffler M, Krajewska M, Hasegawa P, Mukherjee S, Orth K, Krajewski S, Godzik A, Guiney DG, Reed JC. Salmonella secreted factor L deubiquitinase of Salmonella typhimurium inhibits NF-kappaB, suppresses IkappaBalpha ubiquitination and modulates innate immune responses. Journal of Immunology (Baltimore, Md. : 1950). 180: 5045-56. PMID 18354230 DOI: 10.4049/Jimmunol.180.7.5045  0.31
2008 Hao YH, Wang Y, Burdette D, Mukherjee S, Keitany G, Goldsmith E, Orth K. Structural requirements for Yersinia YopJ inhibition of MAP kinase pathways. Plos One. 3: e1375. PMID 18167536 DOI: 10.1371/Journal.Pone.0001375  0.739
2008 Trosky JE, Liverman AD, Orth K. Yersinia outer proteins: Yops. Cellular Microbiology. 10: 557-65. PMID 18081726 DOI: 10.1111/J.1462-5822.2007.01109.X  0.474
2007 Liverman ADB, Cheng HC, Trosky JE, Leung DW, Yarbrough ML, Burdette DL, Rosen MK, Orth K. Arp2/3-independent assembly of actin by Vibrio type III effector VopL Proceedings of the National Academy of Sciences of the United States of America. 104: 17117-17122. PMID 17942696 DOI: 10.1073/Pnas.0703196104  0.736
2007 Trosky JE, Li Y, Mukherjee S, Keitany G, Ball H, Orth K. VopA inhibits ATP binding by acetylating the catalytic loop of MAPK kinases. The Journal of Biological Chemistry. 282: 34299-305. PMID 17881352 DOI: 10.1074/Jbc.M706970200  0.322
2007 Mukherjee S, Hao YH, Orth K. A newly discovered post-translational modification--the acetylation of serine and threonine residues. Trends in Biochemical Sciences. 32: 210-6. PMID 17412595 DOI: 10.1016/J.Tibs.2007.03.007  0.35
2007 Chosed R, Tomchick DR, Brautigam CA, Mukherjee S, Negi VS, Machius M, Orth K. Structural analysis of Xanthomonas XopD provides insights into substrate specificity of ubiquitin-like protein proteases. The Journal of Biological Chemistry. 282: 6773-82. PMID 17204475 DOI: 10.1074/Jbc.M608730200  0.318
2007 Orth K, Caruth W. Versatile Type III Effector Mechanisms Can Disrupt Target-Cell Functions Microbe Magazine. 2: 183-186. DOI: 10.1128/Microbe.2.183.1  0.451
2006 Fehr D, Casanova C, Liverman A, Blazkova H, Orth K, Dobbelaere D, Frey J, Burr SE. AopP, a type III effector protein of Aeromonas salmonicida, inhibits the NF-kappaB signalling pathway. Microbiology (Reading, England). 152: 2809-18. PMID 16946275 DOI: 10.1099/Mic.0.28889-0  0.415
2006 Chosed R, Mukherjee S, Lois LM, Orth K. Evolution of a signalling system that incorporates both redundancy and diversity: Arabidopsis SUMOylation. The Biochemical Journal. 398: 521-9. PMID 16740136 DOI: 10.1042/Bj20060426  0.385
2006 Mukherjee S, Keitany G, Li Y, Wang Y, Ball HL, Goldsmith EJ, Orth K. Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation. Science (New York, N.Y.). 312: 1211-4. PMID 16728640 DOI: 10.1126/Science.1126867  0.409
2004 Trosky JE, Mukherjee S, Burdette DL, Roberts M, McCarter L, Siegel RM, Orth K. Inhibition of MAPK signaling pathways by VopA from Vibrio parahaemolyticus. The Journal of Biological Chemistry. 279: 51953-7. PMID 15459200 DOI: 10.1074/Jbc.M407001200  0.768
2003 Yoon S, Liu Z, Eyobo Y, Orth K. Yersinia effector YopJ inhibits yeast MAPK signaling pathways by an evolutionarily conserved mechanism. The Journal of Biological Chemistry. 278: 2131-5. PMID 12433923 DOI: 10.1074/Jbc.M209905200  0.365
2002 Heussler VT, Rottenberg S, Schwab R, Küenzi P, Fernandez PC, McKellar S, Shiels B, Chen ZJ, Orth K, Wallach D, Dobbelaere DA. Hijacking of host cell IKK signalosomes by the transforming parasite Theileria. Science (New York, N.Y.). 298: 1033-6. PMID 12411708 DOI: 10.1126/Science.1075462  0.391
2002 Collier-Hyams LS, Zeng H, Sun J, Tomlinson AD, Bao ZQ, Chen H, Madara JL, Orth K, Neish AS. Cutting edge: Salmonella AvrA effector inhibits the key proinflammatory, anti-apoptotic NF-kappa B pathway. Journal of Immunology (Baltimore, Md. : 1950). 169: 2846-50. PMID 12218096 DOI: 10.4049/Jimmunol.169.6.2846  0.466
2002 Orth K. Function of the Yersinia effector YopJ. Current Opinion in Microbiology. 5: 38-43. PMID 11834367 DOI: 10.1016/S1369-5274(02)00283-7  0.453
2002 Orth K, Dixon JE, Bliska JB. 20 Effector proteins of bacterial type III protein secretion systems: Elucidating their biochemical effects on eukaryotic signaling cascades Methods in Microbiology. 31: 361-376. DOI: 10.1016/S0580-9517(02)31021-3  0.613
2001 Abe MK, Kahle KT, Saelzler MP, Orth K, Dixon JE, Rosner MR. ERK7 is an autoactivated member of the MAPK family. The Journal of Biological Chemistry. 276: 21272-9. PMID 11287416 DOI: 10.1074/Jbc.M100026200  0.53
2000 Orth K, Xu Z, Mudgett MB, Bao ZQ, Palmer LE, Bliska JB, Mangel WF, Staskawicz B, Dixon JE. Disruption of signaling by Yersinia effector YopJ, a ubiquitin-like protein protease. Science (New York, N.Y.). 290: 1594-7. PMID 11090361 DOI: 10.1126/Science.290.5496.1594  0.581
2000 Juris SJ, Rudolph AE, Huddler D, Orth K, Dixon JE. A distinctive role for the Yersinia protein kinase: actin binding, kinase activation, and cytoskeleton disruption. Proceedings of the National Academy of Sciences of the United States of America. 97: 9431-6. PMID 10920208 DOI: 10.1073/Pnas.170281997  0.577
1999 Orth K, Palmer LE, Bao ZQ, Stewart S, Rudolph AE, Bliska JB, Dixon JE. Inhibition of the mitogen-activated protein kinase kinase superfamily by a Yersinia effector Science. 285: 1920-1923. PMID 10489373 DOI: 10.1126/Science.285.5435.1920  0.602
1997 Wen LP, Fahrni JA, Troie S, Guan JL, Orth K, Rosen GD. Cleavage of focal adhesion kinase by caspases during apoptosis. The Journal of Biological Chemistry. 272: 26056-61. PMID 9325343 DOI: 10.1074/Jbc.272.41.26056  0.35
1997 Orth K, Dixit VM. Bik and Bak induce apoptosis downstream of CrmA but upstream of inhibitor of apoptosis Journal of Biological Chemistry. 272: 8841-8844. PMID 9082997 DOI: 10.1074/Jbc.272.14.8841  0.317
1996 Chinnaiyan AM, Hanna WL, Orth K, Duan H, Poirier GG, Froelich CJ, Dixit VM. Cytotoxic T-cell-derived granzyme B activates the apoptotic protease ICE-LAP3. Current Biology : Cb. 6: 897-9. PMID 8805307 DOI: 10.1016/S0960-9822(02)00614-0  0.32
1992 Orth K, Madison EL, Gething MJ, Sambrook JF, Herz J. Complexes of tissue-type plasminogen activator and its serpin inhibitor plasminogen-activator inhibitor type 1 are internalized by means of the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor. Proceedings of the National Academy of Sciences of the United States of America. 89: 7422-6. PMID 1502153 DOI: 10.1073/Pnas.89.16.7422  0.334
1991 Letsou A, Alexander S, Orth K, Wasserman SA. Genetic and molecular characterization of tube, a Drosophila gene maternally required for embryonic dorsoventral polarity. Proceedings of the National Academy of Sciences of the United States of America. 88: 810-4. PMID 1899484 DOI: 10.1073/Pnas.88.3.810  0.333
1991 Hagen FS, Grant FJ, Kuijper JL, Slaughter CA, Moomaw CR, Orth K, O'Hara PJ, Munford RS. Expression and characterization of recombinant human acyloxyacyl hydrolase, a leukocyte enzyme that deacylates bacterial lipopolysaccharides. Biochemistry. 30: 8415-23. PMID 1883828 DOI: 10.1021/Bi00098A020  0.325
1988 Gil G, Smith JR, Goldstein JL, Slaughter CA, Orth K, Brown MS, Osborne TF. Multiple genes encode nuclear factor 1-like proteins that bind to the promoter for 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Proceedings of the National Academy of Sciences of the United States of America. 85: 8963-7. PMID 3194401 DOI: 10.1073/Pnas.85.23.8963  0.343
1986 Peterson CL, Orth K, Calame KL. Binding in vitro of multiple cellular proteins to immunoglobulin heavy-chain enhancer DNA. Molecular and Cellular Biology. 6: 4168-78. PMID 3025641 DOI: 10.1128/Mcb.6.12.4168  0.345
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