Hidesaburo Hanafusa - US grants

Affiliations:

1973-1998

Rockefeller University, New York, NY, United States

Area:

virology

Website:

https://en.wikipedia.org/wiki/Hidesaburo_Hanafusa

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High-probability grants

According to our matching algorithm, Hidesaburo Hanafusa is the likely recipient of the following grants.

Years	Recipients	Code	Title / Keywords	Matching score
1985 — 1987	Hanafusa, Hidesaburo	R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies.	Cellular Alteration Induced by Rous Sarcoma Virus @ Rockefeller University The basic objective of this research is the elucidation of the mechanism of virus induced neoplastic transformation. The system of Rous sarcoma virus, avian leukosis virus, and chicken cells will be used as a model. We wish to understand the basic mechanism for the genetic interaction between cellular and viral genomes which leads to the generation of oncogenic viruses. In order to understand biochemical basis of cell transformation process induced by avian retroviruses, characterization of products of transforming genes of several sarcoma, and acute leukemia viruses will be made. Finally, we wish to understand the basis of control of expression of viral or cellular src genome by various regulatory elements including viral promoter sequences. Show summary Hide summary	1
1986 — 1990	Hanafusa, Hidesaburo	T32Activity Code Description: To enable institutions to make National Research Service Awards to individuals selected by them for predoctoral and postdoctoral research training in specified shortage areas.	Mechanisms in Virus Infection and Transformation @ Rockefeller University	1
1987 — 1999	Hanafusa, Hidesaburo	R35Activity Code Description: To provide long term support to an experienced investigator with an outstanding record of research productivity. This support is intended to encourage investigators to embark on long-term projects of unusual potential.	Analysis of Cell Transformation by Retrovirus @ Rockefeller University The basic objective of this research is the elucidation of the mechanism of neoplastic transformation of cells. Special emphasis will be placed on the biochemical analysis of the process of transformation in cells infected with avian sarcoma viruses. The studies will include the determination of subcellular localization of oncogene products, and identification of target host protein(s) whose phosphorylation is critical for cell transformation, and the characterization of changes in the expression of normal cellular genes in the process of transformation. Efforts will be made to identify cellular genes required for transformation. Analysis of the structure and functions of cellular and viral oncogene products and the conditions required for the conversion of the former to the latter will be investigated. As a part of this project we will analyze the mechanism of activation of the c-src protein by polyoma virus. The basis for tissue specific transformation by some oncogenic viruses will be explored. In order to understand the possible function of certain proto- oncogenes in normal cells, their expression will be analyzed in various cells at different developmental stages of animals. Show summary Hide summary	1
1991 — 1997	Hanafusa, Hidesaburo	T32Activity Code Description: To enable institutions to make National Research Service Awards to individuals selected by them for predoctoral and postdoctoral research training in specified shortage areas.	Mechanisms in Virus Transformation and Cell Regulation @ Rockefeller University	1
1994 — 1996	Hanafusa, Hidesaburo	R35Activity Code Description: To provide long term support to an experienced investigator with an outstanding record of research productivity. This support is intended to encourage investigators to embark on long-term projects of unusual potential.	Cell Transformation by Retrovirus @ Rockefeller University	1