Jun R. Huh, Ph.D.

California Institute of Technology, Pasadena, CA 
"Jun Huh"


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Bruce Hay grad student 2005 Caltech
 (To die or to differentiate: Apoptotic and non-apoptotic roles of death molecules in Drosophila melanogaster.)
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Longman RS, Diehl GE, Victorio DA, et al. (2014) CX₃CR1⁺ mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22. The Journal of Experimental Medicine. 211: 1571-83
Huh JR, Englund EE, Wang H, et al. (2013) Identification of Potent and Selective Diphenylpropanamide RORγ Inhibitors. Acs Medicinal Chemistry Letters. 4: 79-84
Huh JR, Littman DR. (2012) Small molecule inhibitors of RORγt: targeting Th17 cells and other applications. European Journal of Immunology. 42: 2232-7
Huh JR, Leung MW, Huang P, et al. (2011) Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity. Nature. 472: 486-90
Huh JR, Foe I, Muro I, et al. (2007) The Drosophila inhibitor of apoptosis (IAP) DIAP2 is dispensable for cell survival, required for the innate immune response to gram-negative bacterial infection, and can be negatively regulated by the reaper/hid/grim family of IAP-binding apoptosis inducers. The Journal of Biological Chemistry. 282: 2056-68
Muro I, Berry DL, Huh JR, et al. (2006) The Drosophila caspase Ice is important for many apoptotic cell deaths and for spermatid individualization, a nonapoptotic process. Development (Cambridge, England). 133: 3305-15
Clark IE, Dodson MW, Jiang C, et al. (2006) Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. Nature. 441: 1162-6
Yan N, Huh JR, Schirf V, et al. (2006) Structure and activation mechanism of the Drosophila initiator caspase Dronc. The Journal of Biological Chemistry. 281: 8667-74
Hay BA, Huh JR, Guo M. (2004) The genetics of cell death: approaches, insights and opportunities in Drosophila. Nature Reviews. Genetics. 5: 911-22
Huh JR, Guo M, Hay BA. (2004) Compensatory proliferation induced by cell death in the Drosophila wing disc requires activity of the apical cell death caspase Dronc in a nonapoptotic role. Current Biology : Cb. 14: 1262-6
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