Norbert Perrimon

1986- Genetics Harvard University, Cambridge, MA, United States 
"Norbert Perrimon"

Dr. Perrimon has 30 years of experience in the fields of developmental genetics, signal transduction and genomics. By developing, improving, and applying a number of genetic techniques (germline clones, FLP/FRT, Gal4/UAS, etc.), his group identified many key components of the Receptor Tyrosine Kinases, JAK/STAT, Wnt, Hedgehog and Notch signaling pathways. In recent years, his group established high-throughput genome-wide RNAi screens to systematically interrogate the entire Drosophila genome in various cell-based assays. In 2003 he created the Drosophila RNAi Screening Center at Harvard Medical School to make this technology available to the community. In addition, in 2008, he initiated the Transgenic RNAi Project to generate transgenic RNAi lines for the community using optimized shRNA vectors that his lab developed. Currently, his laboratory is applying large-scale RNAi and proteomic methods to obtain a global understanding to the structure of a number of signaling pathways and their crosstalks. In addition, he is studying the roles of signaling pathways in homeostasis and tissue remodeling in Drosophila muscles and gut stem cells. Dr. Perrimon has trained more than 80 students and postdoctoral fellows, most of whom currently hold academic positions.
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Cross-listing: Neurotree - Computational Biology Tree


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Madeleine Gans grad student 1983 University of Paris VI
 (Thesis: "Analyse Clonale de Mutations en Lignee Germinale chez la Drosophile")
Anthony P. Mahowald post-doc 1983-1986 Chicago


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Kimberly Sayer Kerr research assistant 1998-2005 Harvard Medical School (Neurotree)
Ilia Droujinine grad student Harvard Medical School (Neurotree)
Young Kwon grad student Harvard Medical School (Neurotree)
John A. Klingensmith grad student 1986-1993 Harvard
Yohanns Bellaïche grad student 1994-1998 Harvard
Adam Amiel Friedman grad student 2007 Harvard
William Tyler Gibson grad student 2012 Harvard
Jimmy Kuang-Hsien Hu grad student 2012 Harvard
Erika Bach post-doc NYU School of Medicine
Chris Bakal post-doc Harvard Medical School (Neurotree)
David Bilder post-doc
Andrea H. Brand post-doc Harvard
Katja Brueckner post-doc
Nirmalya Chatterjee post-doc (Neurotree)
Sara Cherry post-doc
Daniel F. Eberl post-doc
Arpan C. Ghosh post-doc Harvard Medical School
Udo Häcker post-doc Harvard Medical School
Douglas A. Harrison post-doc
Li He post-doc Harvard Medical School
Xinhua Lin post-doc
Chryssoula Pitsouli post-doc Harvard Medical School
Esther Seigfried post-doc
Eric Spana post-doc
Change Tan post-doc University of Missouri
Stephane Vincent post-doc ENS Lyon
Raghuvir R. Viswanatha post-doc Harvard Medical School (Cell Biology Tree)
Frederik Wirtz-Peitz post-doc Harvard
Jonathan D. Zirin post-doc
Ben Ewen-Campen post-doc 2014- Harvard Medical School
Afroditi Petsakou post-doc 2015- Harvard Medical School (Chemistry Tree)
Sudhir Gopal Tattikota post-doc 2016- Harvard Medical School (Neurotree)
Lucy Liu post-doc 2017- Harvard Medical School (Neurotree)
Rajendhran Rajakumar post-doc 2017- Harvard Medical School (Neurotree)
Joshua Shing Shun Li post-doc 2019- Harvard Medical School (Neurotree)
Jun Xu post-doc 2019- Harvard Medical School (Neurotree)
Jeff Axelrod post-doc 1993-1998 Harvard Medical School
Willis X Li post-doc 1995-2000 Harvard Medical School
Beth E. Stronach post-doc 1998-2002 genetics department, harvard medical school
Frieder Schöck post-doc 1999-2003 Harvard Medical School
Amy Kiger post-doc 2000-2004 Harvard
Craig A. Micchelli post-doc 2000-2006 Harvard (Cell Biology Tree)
Matt Gibson post-doc 2001-2006 Harvard
Michele Markstein post-doc 2004-2012 Harvard Medical School
Marla B. Tipping post-doc 2011-2013 Harvard
Phillip Karpowicz post-doc 2008-2014 Harvard Medical School
Edward K. Owusu-Ansah post-doc 2009-2014 Harvard Medical School (Neurotree)
Akhila Rajan post-doc 2009-2016 Harvard Medical School
Dong Yan post-doc 2010-2016
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Xu J, Liu Y, Li H, et al. (2022) Transcriptional and functional motifs defining renal function revealed by single-nucleus RNA sequencing. Proceedings of the National Academy of Sciences of the United States of America. 119: e2203179119
Viswanatha R, Mameli E, Rodiger J, et al. (2022) Author Correction: Bioinformatic and cell-based tools for pooled CRISPR knockout screening in mosquitos. Nature Communications. 13: 1813
Li H, Janssens J, De Waegeneer M, et al. (2022) Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly. Science (New York, N.Y.). 375: eabk2432
Xu J, Kim AR, Cheloha RW, et al. (2022) Protein visualization and manipulation in through the use of epitope tags recognized by nanobodies. Elife. 11
Zirin J, Bosch J, Viswanatha R, et al. (2021) State-of-the-art CRISPR for in vivo and cell-based studies in Drosophila. Trends in Genetics : Tig
Viswanatha R, Mameli E, Rodiger J, et al. (2021) Bioinformatic and cell-based tools for pooled CRISPR knockout screening in mosquitos. Nature Communications. 12: 6825
Tattikota SG, Perrimon N. (2021) Preparation of Larval Blood Cells for Single-cell RNA Sequencing. Bio-Protocol. 11: e4127
Chatterjee N, Perrimon N. (2021) What fuels the fly: Energy metabolism in and its application to the study of obesity and diabetes. Science Advances. 7
Hu Y, Tattikota SG, Liu Y, et al. (2021) DRscDB: A single-cell RNA-seq resource for data mining and data comparison across species. Computational and Structural Biotechnology Journal. 19: 2018-2026
Droujinine IA, Meyer AS, Wang D, et al. (2021) Proteomics of protein trafficking by in vivo tissue-specific labeling. Nature Communications. 12: 2382
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