J Lawrence Marsh

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"J Marsh"
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Liu KY, Shyu YC, Barbaro BA, et al. (2015) Disruption of the nuclear membrane by perinuclear inclusions of mutant huntingtin causes cell-cycle re-entry and striatal cell death in mouse and cell models of Huntington's disease. Human Molecular Genetics. 24: 1602-16
Barbaro BA, Lukacsovich T, Agrawal N, et al. (2015) Comparative study of naturally occurring huntingtin fragments in Drosophila points to exon 1 as the most pathogenic species in Huntington's disease. Human Molecular Genetics. 24: 913-25
Ochaba J, Lukacsovich T, Csikos G, et al. (2014) Potential function for the Huntingtin protein as a scaffold for selective autophagy. Proceedings of the National Academy of Sciences of the United States of America. 111: 16889-94
Smith MR, Syed A, Lukacsovich T, et al. (2014) A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease. Human Molecular Genetics. 23: 2995-3007
O'Rourke JG, Gareau JR, Ochaba J, et al. (2013) SUMO-2 and PIAS1 modulate insoluble mutant huntingtin protein accumulation. Cell Reports. 4: 362-75
Song W, Smith MR, Syed A, et al. (2013) Morphometric analysis of Huntington's disease neurodegeneration in Drosophila. Methods in Molecular Biology (Clifton, N.J.). 1017: 41-57
Sontag EM, Lotz GP, Agrawal N, et al. (2012) Methylene blue modulates huntingtin aggregation intermediates and is protective in Huntington's disease models. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 11109-19
Jia H, Pallos J, Jacques V, et al. (2012) Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems of Huntington's disease. Neurobiology of Disease. 46: 351-61
Bodai L, Marsh JL. (2012) A novel target for Huntington's disease: ERK at the crossroads of signaling. The ERK signaling pathway is implicated in Huntington's disease and its upregulation ameliorates pathology. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 34: 142-8
Bodai L, Pallos J, Thompson LM, et al. (2012) Pcaf modulates polyglutamine pathology in a Drosophila model of Huntington's disease. Neuro-Degenerative Diseases. 9: 104-6
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