Matthew Freeman

MRC Laboratory of Molecular Biology, Cambridge, England, United Kingdom 
 University of Oxford, Oxford, United Kingdom 
cell biology, signalling, physiology
"Matthew Freeman"
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Grieve AG, Yeh YC, Chang YF, et al. (2021) Conformational surveillance of Orai1 by a rhomboid intramembrane protease prevents inappropriate CRAC channel activation. Molecular Cell
Muliyil S, Levet C, Düsterhöft S, et al. (2020) ADAM17-triggered TNF signalling protects the ageing Drosophila retina from lipid droplet-mediated degeneration. The Embo Journal. e104415
Liu G, Beaton SE, Grieve AG, et al. (2020) Bacterial rhomboid proteases mediate quality control of orphan membrane proteins. The Embo Journal. e102922
Freeman M. (2020) Rhomboid Proteins in Cell Signaling The Faseb Journal. 34: 1-1
Ikeda KN, Freeman M. (2019) Spatial proteomics reveal that the protein phosphatase PTP1B interacts with and may modify tyrosine phosphorylation of the rhomboid protease RHBDL4. The Journal of Biological Chemistry
Dulloo I, Muliyil S, Freeman M. (2019) The molecular, cellular and pathophysiological roles of iRhom pseudoproteases. Open Biology. 9: 190003
Künzel U, Grieve AG, Meng Y, et al. (2018) FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex. Elife. 7
Johnson N, Březinová J, Stephens E, et al. (2017) Quantitative proteomics screen identifies a substrate repertoire of rhomboid protease RHBDL2 in human cells and implicates it in epithelial homeostasis. Scientific Reports. 7: 7283
Düsterhöft S, Künzel U, Freeman M. (2017) Rhomboid proteases in human disease: Mechanisms and future prospects. Biochimica Et Biophysica Acta
Grieve AG, Xu H, Künzel U, et al. (2017) Phosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling. Elife. 6
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