Julien Muffat

Affiliations: 
2017- Neurosciences and Mental Health The Hospital for Sick Children / University of Toronto, Toronto, Ontario, Canada 
Area:
stem cells, neurodegeneration, inflammation, pathological aging, microglia, neuro-immune
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"Julien Muffat"
Cross-listing: Neurotree

Parents

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Alain Berthoz research assistant Whitehead Institute for Biomedical Research (Neurotree)
Werner Graf research assistant CNRS, Collège de France (Neurotree)
Gabriella Ugolini research assistant NBCM - CNRS Gif sur Yvette (Neurotree)
David J. Anderson grad student Caltech (Neurotree)
Henry A. Lester grad student Caltech (Neurotree)
Rudolph E. Tanzi grad student Harvard Medical School (Neurotree)
Seymour Benzer grad student 2002-2007 Caltech
Rudolf Jaenisch post-doc 2009-2017 Whitehead Institute for Biomedical Research (Neurotree)
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Publications

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Trapecar M, Wogram E, Svoboda D, et al. (2021) Human physiomimetic model integrating microphysiological systems of the gut, liver, and brain for studies of neurodegenerative diseases. Science Advances. 7
Tian A, Muffat J, Li Y. (2020) Studying Human Neurodevelopment and Diseases Using 3D Brain Organoids. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 40: 1186-1193
Li Y, Muffat J, Omer Javed A, et al. (2019) Genome-wide CRISPR screen for Zika virus resistance in human neural cells. Proceedings of the National Academy of Sciences of the United States of America
Omer Javed A, Li Y, Muffat J, et al. (2018) Microcephaly Modeling of Kinetochore Mutation Reveals a Brain-Specific Phenotype. Cell Reports. 25: 368-382.e5
Muffat J, Li Y, Omer A, et al. (2018) Human induced pluripotent stem cell-derived glial cells and neural progenitors display divergent responses to Zika and dengue infections. Proceedings of the National Academy of Sciences of the United States of America
Liu XS, Wu H, Krzisch M, et al. (2018) Rescue of Fragile X Syndrome Neurons by DNA Methylation Editing of the FMR1 Gene. Cell
Li Y, Muffat J, Omer A, et al. (2016) Induction of Expansion and Folding in Human Cerebral Organoids. Cell Stem Cell
Muffat J, Li Y, Jaenisch R. (2016) CNS disease models with human pluripotent stem cells in the CRISPR age. Current Opinion in Cell Biology. 43: 96-103
Muffat J, Li Y, Yuan B, et al. (2016) Efficient derivation of microglia-like cells from human pluripotent stem cells. Nature Medicine
Choi SH, Kim YH, Hebisch M, et al. (2014) A three-dimensional human neural cell culture model of Alzheimer's disease. Nature. 515: 274-8
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