Julien Muffat

Affiliations: 
2017- Neurosciences and Mental Health The Hospital for Sick Children / University of Toronto, Toronto, Ontario, Canada 
Area:
stem cells, neurodegeneration, inflammation, pathological aging, microglia, neuro-immune
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"Julien Muffat"
Cross-listing: Neurotree

Parents

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Alain Berthoz research assistant Whitehead Institute for Biomedical Research (Neurotree)
Werner Graf research assistant CNRS, Collège de France (Neurotree)
Gabriella Ugolini research assistant NBCM - CNRS Gif sur Yvette (Neurotree)
David J. Anderson grad student Caltech (Neurotree)
Henry A. Lester grad student Caltech (Neurotree)
Rudolph E. Tanzi grad student Harvard Medical School (Neurotree)
Seymour Benzer grad student 2002-2007 Caltech
Rudolf Jaenisch post-doc 2009-2017 Whitehead Institute for Biomedical Research (Neurotree)

Children

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Yuliya Zubak research assistant 2019-2019 University of Toronto (Sick Kids) (Neurotree)
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Publications

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Ahmed M, Muffat J, Li Y. (2023) Understanding neural development and diseases using CRISPR screens in human pluripotent stem cell-derived cultures. Frontiers in Cell and Developmental Biology. 11: 1158373
Bhattacharya A, Choi WWY, Muffat J, et al. (2021) Modeling developmental brain diseases using human pluripotent stem cell-derived brain organoids - progress and perspective. Journal of Molecular Biology. 167386
Dhaliwal N, Choi WWY, Muffat J, et al. (2021) Modeling PTEN overexpression-induced microcephaly in human brain organoids. Molecular Brain. 14: 131
Trapecar M, Wogram E, Svoboda D, et al. (2021) Human physiomimetic model integrating microphysiological systems of the gut, liver, and brain for studies of neurodegenerative diseases. Science Advances. 7
Tian A, Muffat J, Li Y. (2020) Studying Human Neurodevelopment and Diseases Using 3D Brain Organoids. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 40: 1186-1193
Li Y, Muffat J, Omer Javed A, et al. (2019) Genome-wide CRISPR screen for Zika virus resistance in human neural cells. Proceedings of the National Academy of Sciences of the United States of America
Omer Javed A, Li Y, Muffat J, et al. (2018) Microcephaly Modeling of Kinetochore Mutation Reveals a Brain-Specific Phenotype. Cell Reports. 25: 368-382.e5
Muffat J, Li Y, Omer A, et al. (2018) Human induced pluripotent stem cell-derived glial cells and neural progenitors display divergent responses to Zika and dengue infections. Proceedings of the National Academy of Sciences of the United States of America
Liu XS, Wu H, Krzisch M, et al. (2018) Rescue of Fragile X Syndrome Neurons by DNA Methylation Editing of the FMR1 Gene. Cell
Li Y, Muffat J, Omer A, et al. (2016) Induction of Expansion and Folding in Human Cerebral Organoids. Cell Stem Cell
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