Fred Y. Wu, Ph.D.

Affiliations: 
2003 Johns Hopkins University, Baltimore, MD 
Area:
Microbiology
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"Fred Wu"

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Gary S. Hayward grad student 2003 Johns Hopkins
 (Manipulation of the cellular environment by human gamma-class herpesvirus early lytic proteins (KSHV RAP and EBV ZTA) during the viral lytic cycle.)
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Publications

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Wang SE, Narasanna A, Whitell CW, et al. (2007) Convergence of p53 and transforming growth factor beta (TGFbeta) signaling on activating expression of the tumor suppressor gene maspin in mammary epithelial cells. The Journal of Biological Chemistry. 282: 5661-9
Huang J, Liao G, Chen H, et al. (2006) Contribution of C/EBP proteins to Epstein-Barr virus lytic gene expression and replication in epithelial cells. Journal of Virology. 80: 1098-109
Chen H, Huang J, Wu FY, et al. (2005) Regulation of expression of the Epstein-Barr virus BamHI-A rightward transcripts. Journal of Virology. 79: 1724-33
Wu FY, Wang SE, Chen H, et al. (2004) CCAAT/enhancer binding protein alpha binds to the Epstein-Barr virus (EBV) ZTA protein through oligomeric interactions and contributes to cooperative transcriptional activation of the ZTA promoter through direct binding to the ZII and ZIIIB motifs during induction of the EBV lytic cycle. Journal of Virology. 78: 4847-65
Wang SE, Wu FY, Chen H, et al. (2004) Early activation of the Kaposi's sarcoma-associated herpesvirus RTA, RAP, and MTA promoters by the tetradecanoyl phorbol acetate-induced AP1 pathway. Journal of Virology. 78: 4248-67
Wang SE, Wu FY, Yu Y, et al. (2003) CCAAT/enhancer-binding protein-alpha is induced during the early stages of Kaposi's sarcoma-associated herpesvirus (KSHV) lytic cycle reactivation and together with the KSHV replication and transcription activator (RTA) cooperatively stimulates the viral RTA, MTA, and PAN promoters. Journal of Virology. 77: 9590-612
Wu FY, Wang SE, Tang QQ, et al. (2003) Cell cycle arrest by Kaposi's sarcoma-associated herpesvirus replication-associated protein is mediated at both the transcriptional and posttranslational levels by binding to CCAAT/enhancer-binding protein alpha and p21(CIP-1). Journal of Virology. 77: 8893-914
Fujimuro M, Wu FY, ApRhys C, et al. (2003) A novel viral mechanism for dysregulation of beta-catenin in Kaposi's sarcoma-associated herpesvirus latency. Nature Medicine. 9: 300-6
Wu FY, Chen H, Wang SE, et al. (2003) CCAAT/enhancer binding protein alpha interacts with ZTA and mediates ZTA-induced p21(CIP-1) accumulation and G(1) cell cycle arrest during the Epstein-Barr virus lytic cycle. Journal of Virology. 77: 1481-500
Wang SE, Wu FY, Fujimuro M, et al. (2003) Role of CCAAT/enhancer-binding protein alpha (C/EBPalpha) in activation of the Kaposi's sarcoma-associated herpesvirus (KSHV) lytic-cycle replication-associated protein (RAP) promoter in cooperation with the KSHV replication and transcription activator (RTA) and RAP. Journal of Virology. 77: 600-23
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