Kenneth M. Humphries, Ph.D.

Affiliations: 
2000 Case Western Reserve University School of Medicine, Cleveland, OH, United States 
Area:
Biochemistry, General Biophysics, Molecular Biology
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Luke I. Szweda grad student 2000 Case Western Medical School
 (Inhibition of NADH-linked mitochondrial respiration by 4 -hydroxy -2 -nonenal: A mechanism of free radical mediated mitochondrial dysfunction.)
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Publications

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Faakye A, Harold KM, Matsuzaki S, et al. (2025) The effect of enhanced glycolysis on cardiac aging. Geroscience
Mendez Garcia MF, Matsuzaki S, Batushansky A, et al. (2023) Increased cardiac PFK-2 protects against high-fat diet-induced cardiomyopathy and mediates beneficial systemic metabolic effects. Iscience. 26: 107131
Li P, Newhardt MF, Matsuzaki S, et al. (2022) The loss of cardiac SIRT3 decreases metabolic flexibility and proteostasis in an age-dependent manner. Geroscience
Eyster CA, Matsuzaki S, Newhardt MF, et al. (2020) Diabetes induced decreases in PKA signaling in cardiomyocytes: The role of insulin. Plos One. 15: e0231806
Yap ZY, Strucinska K, Matsuzaki S, et al. (2020) A biallelic pathogenic variant in the OGDH gene results in a neurological disorder with features of a mitochondrial disease. Journal of Inherited Metabolic Disease
Newhardt MF, Batushansky A, Matsuzaki S, et al. (2019) Enhancing cardiac glycolysis causes an increase in PDK4 content in response to short term high fat diet. The Journal of Biological Chemistry
Batushansky A, Matsuzaki S, Newhardt MF, et al. (2019) GC-MS metabolic profiling reveals fructose-2,6-bisphosphate regulates branched chain amino acid metabolism in the heart during fasting. Metabolomics : Official Journal of the Metabolomic Society. 15: 18
Pearsall EA, Cheng R, Matsuzaki S, et al. (2019) Neuroprotective effects of PPARα in retinopathy of type 1 diabetes. Plos One. 14: e0208399
Ahn B, Ranjit R, Premkumar P, et al. (2019) Mitochondrial oxidative stress impairs contractile function but paradoxically increases muscle mass via fibre branching. Journal of Cachexia, Sarcopenia and Muscle
Bhaskaran S, Pharaoh G, Ranjit R, et al. (2018) Loss of mitochondrial protease ClpP protects mice from diet-induced obesity and insulin resistance. Embo Reports
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