|Ohio State University, Columbus, Columbus, OH|
Area:Drosophila midline axon guidance
Dr.Mark Seeger obtained his PhD under the mentorship of Dr.Thomas Kauffmann at Indiana University at Bloomington, working on pattern formation in early embryonic development of the fruitfly. He then worked with Dr.Corey Goodman at University of California, Berkeley understanding the molecular mechanisms of axon guidance.
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|Randeria PS, Seeger MA, Wang XQ, et al. (2015) siRNA-based spherical nucleic acids reverse impaired wound healing in diabetic mice by ganglioside GM3 synthase knockdown. Proceedings of the National Academy of Sciences of the United States of America. 112: 5573-8|
|Wang XQ, Lee S, Wilson H, et al. (2014) Ganglioside GM3 depletion reverses impaired wound healing in diabetic mice by activating IGF-1 and insulin receptors. The Journal of Investigative Dermatology. 134: 1446-55|
|Seeger MA, Paller AS. (2014) The role of abnormalities in the distal pathway of cholesterol synthesis in the Congenital Hemidysplasia with Ichthyosiform erythroderma and Limb Defects (CHILD) syndrome. Biochimica Et Biophysica Acta. 1841: 345-52|
|Seeger MA, Rice SE. (2013) Intrinsic Disorder in the Kinesin Superfamily. Biophysical Reviews. 5|
|VaquÃ© JP, Dorsam RT, Feng X, et al. (2013) A genome-wide RNAi screen reveals a Trio-regulated Rho GTPase circuitry transducing mitogenic signals initiated by G protein-coupled receptors. Molecular Cell. 49: 94-108|
|Seeger MA, Zhang Y, Rice SE. (2012) Kinesin tail domains are intrinsically disordered. Proteins. 80: 2437-46|
|Dorsten JN, Varughese BE, Karmo S, et al. (2010) In the absence of frazzled over-expression of Abelson tyrosine kinase disrupts commissure formation and causes axons to leave the embryonic CNS. Plos One. 5: e9822|
|Seeger MA, Rice SE. (2010) Microtubule-associated protein-like binding of the kinesin-1 tail to microtubules. The Journal of Biological Chemistry. 285: 8155-62|
|Challa AK, McWhorter ML, Wang C, et al. (2005) Robo3 isoforms have distinct roles during zebrafish development. Mechanisms of Development. 122: 1073-86|
|Forsthoefel DJ, Liebl EC, Kolodziej PA, et al. (2005) The Abelson tyrosine kinase, the Trio GEF and Enabled interact with the Netrin receptor Frazzled in Drosophila. Development (Cambridge, England). 132: 1983-94|