Alyssa Coyne
Affiliations: | 2011-2016 | Molecular and Cellular Biology | University of Arizona, Tucson, AZ |
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"Alyssa Coyne"
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| Kempthorne L, Vaizoglu D, Cammack AJ, et al. (2025) Dual-targeting CRISPR-CasRx reduces C9orf72 ALS/FTD sense and antisense repeat RNAs in vitro and in vivo. Nature Communications. 16: 459 |
| Keeley O, Mendoza E, Menon D, et al. (2024) CHMP2B promotes CHMP7 mediated nuclear pore complex injury in sporadic ALS. Acta Neuropathologica Communications. 12: 199 |
| Al-Azzam N, To JH, Gautam V, et al. (2024) Inhibition of RNA splicing triggers CHMP7 nuclear entry, impacting TDP-43 function and leading to the onset of ALS cellular phenotypes. Neuron |
| Keeley O, Coyne AN. (2024) Nuclear and degradative functions of the ESCRT-III pathway: implications for neurodegenerative disease. Nucleus (Austin, Tex.). 15: 2349085 |
| Milioto C, Carcolé M, Giblin A, et al. (2024) PolyGR and polyPR knock-in mice reveal a conserved neuroprotective extracellular matrix signature in C9orf72 ALS/FTD neurons. Nature Neuroscience |
| Rothstein JD, Warlick C, Coyne AN. (2023) Highly variable molecular signatures of TDP-43 loss of function are associated with nuclear pore complex injury in a population study of sporadic ALS patient iPSNs. Biorxiv : the Preprint Server For Biology |
| Rothstein JD, Baskerville V, Rapuri S, et al. (2023) GC targeting antisense oligonucleotides potently mitigate TDP-43 dysfunction in human C9orf72 ALS/FTD induced pluripotent stem cell derived neurons. Acta Neuropathologica. 147: 1 |
| Baskerville V, Rapuri S, Mehlhop E, et al. (2023) SUN1 facilitates CHMP7 nuclear influx and injury cascades in sporadic amyotrophic lateral sclerosis. Brain : a Journal of Neurology |
| Li J, Lim RG, et al. (2021) An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients. Iscience. 24: 103221 |
| Coyne AN, Baskerville V, Zaepfel BL, et al. (2021) Nuclear accumulation of CHMP7 initiates nuclear pore complex injury and subsequent TDP-43 dysfunction in sporadic and familial ALS. Science Translational Medicine. 13 |