James Luccarelli, DPhil
Affiliations: | University of Oxford, Oxford, United Kingdom |
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"James Luccarelli"Mean distance: 8.23 | S | N | B | C | P |
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Publications
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| Peacock H, Henriques ST, Benfield AH, et al. (2020) Antimicrobial peptide mimetics based on a diphenylacetylene scaffold: synthesis, conformational analysis and activity. Chemmedchem |
| Harvey EP, Hauseman ZJ, Cohen DT, et al. (2020) Identification of a Covalent Molecular Inhibitor of Anti-apoptotic BFL-1 by Disulfide Tethering. Cell Chemical Biology |
| Luccarelli J, Jones IM, Thompson S, et al. (2017) Unpicking the determinants of amide NHO[double bond, length as m-dash]C hydrogen bond strength with diphenylacetylene molecular balances. Organic & Biomolecular Chemistry |
| Pritz JR, Wachter F, Lee S, et al. (2017) Allosteric sensitization of proapoptotic BAX. Nature Chemical Biology |
| Peacock H, Luo J, Yamashita T, et al. (2016) Non-covalent S···O interactions control conformation in a scaffold that disrupts islet amyloid polypeptide fibrillation. Chemical Science. 7: 6435-6439 |
| Lee S, Wales TE, Escudero S, et al. (2016) Allosteric inhibition of antiapoptotic MCL-1. Nature Structural & Molecular Biology |
| Lee S, Wales TE, Gallagher C, et al. (2016) Abstract 3553: A novel allosteric mechanism for molecular inhibition of anti-apoptotic MCL-1 Cancer Research. 76: 3553-3553 |
| Edwards AL, Wachter F, Lammert M, et al. (2015) Cellular Uptake and Ultrastructural Localization Underlie the Pro-apoptotic Activity of a Hydrocarbon-stapled BIM BH3 Peptide. Acs Chemical Biology |
| Leshchiner ES, Parkhitko A, Bird GH, et al. (2015) Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices. Proceedings of the National Academy of Sciences of the United States of America. 112: 1761-6 |
| Simister PC, Luccarelli J, Thompson S, et al. (2013) Novel inhibitors of a Grb2 SH3C domain interaction identified by a virtual screen. Bioorganic & Medicinal Chemistry. 21: 4027-33 |