| Year |
Citation |
Score |
| 2006 |
Olsen CA, Mellor IR, Wellendorph P, Usherwood PN, Witt M, Franzyk H, Jaroszewski JW. Tuning wasp toxin structure for nicotinic receptor antagonism: cyclohexylalanine-containing analogues as potent and voltage-dependent blockers. Chemmedchem. 1: 303-5. PMID 16892364 DOI: 10.1002/Cmdc.200500067 |
0.321 |
|
| 2006 |
Olsen C, Mellor I, Wellendorph P, Usherwood P, Witt M, Franzyk H, Jaroszewski J. Cover Picture: Tuning Wasp Toxin Structure for Nicotinic Receptor Antagonism: Cyclohexylalanine-Containing Analogues as Potent and Voltage-Dependent Blockers (ChemMedChem 3/2006) Chemmedchem. 1: 281-281. DOI: 10.1002/Cmdc.200690006 |
0.318 |
|
| 2005 |
Bolshakov KV, Kim KH, Potapjeva NN, Gmiro VE, Tikhonov DB, Usherwood PN, Mellor IR, Magazanik LG. Design of antagonists for NMDA and AMPA receptors. Neuropharmacology. 49: 144-55. PMID 15996563 DOI: 10.1016/j.neuropharm.2005.02.007 |
0.435 |
|
| 2004 |
Tikhonov DB, Mellor IR, Usherwood PN. Modeling noncompetitive antagonism of a nicotinic acetylcholine receptor. Biophysical Journal. 87: 159-70. PMID 15240454 DOI: 10.1529/biophysj.103.037457 |
0.3 |
|
| 2004 |
Mellor IR, Usherwood PN. Targeting ionotropic receptors with polyamine-containing toxins. Toxicon : Official Journal of the International Society On Toxinology. 43: 493-508. PMID 15066409 DOI: 10.1016/j.toxicon.2004.02.003 |
0.399 |
|
| 2003 |
Brier TJ, Mellor IR, Tikhonov DB, Neagoe I, Shao Z, Brierley MJ, Strømgaard K, Jaroszewski JW, Krogsgaard-Larsen P, Usherwood PN. Contrasting actions of philanthotoxin-343 and philanthotoxin-(12) on human muscle nicotinic acetylcholine receptors. Molecular Pharmacology. 64: 954-64. PMID 14500752 DOI: 10.1124/mol.64.4.954 |
0.351 |
|
| 2003 |
Mellor IR, Brier TJ, Pluteanu F, Strømgaard K, Saghyan A, Eldursi N, Brierley MJ, Andersen K, Jaroszewski JW, Krogsgaard-Larsen P, Usherwood PN. Modification of the philanthotoxin-343 polyamine moiety results in different structure-activity profiles at muscle nicotinic ACh, NMDA and AMPA receptors. Neuropharmacology. 44: 70-80. PMID 12559123 DOI: 10.1016/S0028-3908(02)00336-2 |
0.388 |
|
| 2002 |
Tikhonov DB, Mellor JR, Usherwood PN, Magazanik LG. Modeling of the pore domain of the GLUR1 channel: homology with K+ channel and binding of channel blockers. Biophysical Journal. 82: 1884-93. PMID 11916847 DOI: 10.1016/S0006-3495(02)75538-0 |
0.312 |
|
| 2000 |
Strømgaard K, Brier TJ, Andersen K, Mellor IR, Saghyan A, Tikhonov D, Usherwood PN, Krogsgaard-Larsen P, Jaroszewski JW. Solid-phase synthesis and biological evaluation of a combinatorial library of philanthotoxin analogues. Journal of Medicinal Chemistry. 43: 4526-33. PMID 11087577 DOI: 10.1021/jm000220n |
0.31 |
|
| 2000 |
Usherwood PN. Natural and synthetic polyamines: modulators of signalling proteins. Farmaco (Società Chimica Italiana : 1989). 55: 202-5. PMID 10919083 DOI: 10.1016/S0014-827X(00)00023-9 |
0.338 |
|
| 2000 |
Strømgaard K, Bjørnsdottir I, Andersen K, Brierley MJ, Rizoli S, Eldursi N, Mellor IR, Usherwood PN, Hansen SH, Krogsgaard-Larsen P, Jaroszewski JW. Solid phase synthesis and biological evaluation of enantiomerically pure wasp toxin analogues PhTX-343 and PhTX-12. Chirality. 12: 93-102. PMID 10637415 DOI: 10.1002/(SICI)1520-636X(2000)12:2<93::AID-CHIR6>3.0.CO;2-B |
0.322 |
|
| 1999 |
Stromgaard K, Brierley MJ, Andersen K, Sløk FA, Mellor IR, Usherwood PN, Krogsgaard-Larsen P, Jaroszewski JW. Analogues of neuroactive polyamine wasp toxins that lack inner basic sites exhibit enhanced antagonism toward a muscle-type mammalian nicotinic acetylcholine receptor. Journal of Medicinal Chemistry. 42: 5224-34. PMID 10602707 DOI: 10.1021/jm9903747 |
0.4 |
|
| 1999 |
Jayaraman V, Usherwood PN, Hess GP. Inhibition of nicotinic acetylcholine receptor by philanthotoxin-343: kinetic investigations in the microsecond time region using a laser-pulse photolysis technique. Biochemistry. 38: 11406-14. PMID 10471291 DOI: 10.1021/Bi991219X |
0.351 |
|
| 1998 |
Shao Z, Mellor IR, Brierley MJ, Harris J, Usherwood PN. Potentiation and inhibition of nicotinic acetylcholine receptors by spermine in the TE671 human muscle cell line. The Journal of Pharmacology and Experimental Therapeutics. 286: 1269-76. PMID 9732388 |
0.353 |
|
| 1998 |
Soloviev MM, Abutidze K, Mellor I, Streit P, Grishin EV, Usherwood PN, Barnard EA. Plasticity of agonist binding sites in hetero-oligomers of the unitary glutamate receptor subunit XenU1. Journal of Neurochemistry. 71: 991-1001. PMID 9721724 DOI: 10.1046/J.1471-4159.1998.71030991.X |
0.374 |
|
| 1997 |
Magazanik LG, Buldakova SL, Samoilova MV, Gmiro VE, Mellor IR, Usherwood PN. Block of open channels of recombinant AMPA receptors and native AMPA/kainate receptors by adamantane derivatives. The Journal of Physiology. 505: 655-63. PMID 9457643 DOI: 10.1111/j.1469-7793.1997.655ba.x |
0.448 |
|
| 1997 |
Tomlinson SR, Kirwin S, Mellor I, Harris J, Mundey M, Brierley M, Bell DR, Usherwood PN. Interaction of a polyamine amide wasp toxin with cloned and mutant glutamate receptors. Biochemical Society Transactions. 25: 551S. PMID 9388765 |
0.338 |
|
| 1996 |
Magazanik LG, Usherwood PN. Competitive antagonism of recombinant AMPA/kainate receptors by N-methyl-D-aspartate and analogues. Neuroreport. 8: 257-9. PMID 9051791 |
0.401 |
|
| 1996 |
Soloviev MM, Brierley MJ, Shao ZY, Mellor IR, Volkova TM, Kamboj R, Ishimaru H, Sudan H, Harris J, Foldes RL, Grishin EV, Usherwood PN, Barnard EA. Functional expression of a recombinant unitary glutamate receptor from Xenopus, which contains N-methyl-D-aspartate (NMDA) and non-NMDA receptor subunits. The Journal of Biological Chemistry. 271: 32572-9. PMID 8955083 DOI: 10.1074/jbc.271.51.32572 |
0.404 |
|
| 1996 |
Green AC, Nakanishi K, Usherwood PN. Polyamine amides are neuroprotective in cerebellar granule cell cultures challenged with excitatory amino acids. Brain Research. 717: 135-46. PMID 8738263 DOI: 10.1016/0006-8993(96)00042-X |
0.441 |
|
| 1996 |
Ishimaru H, Kamboj R, Ambrosini A, Henley JM, Soloviev MM, Sudan H, Rossier J, Abutidze K, Rampersad V, Usherwood PN, Bateson AN, Barnard EA. A unitary non-NMDA receptor short subunit from Xenopus: DNA cloning and expression. Receptors & Channels. 4: 31-49. PMID 8723645 |
0.423 |
|
| 1996 |
Mellor IR, Nakanishi K, Usherwood PN. The actions of philanthotoxin and its structural analogues on ionotropic glutamate and nicotinic acetylcholine receptors Toxicon. 34: 730. DOI: 10.1016/0041-0101(96)89684-X |
0.468 |
|
| 1995 |
Choi SK, Kalivretenos AG, Usherwood PN, Nakanishi K. Labeling studies of photolabile philanthotoxins with nicotinic acetylcholine receptors: mode of interaction between toxin and receptor. Chemistry & Biology. 2: 23-32. PMID 9383400 DOI: 10.1016/1074-5521(95)90077-2 |
0.475 |
|
| 1995 |
Bhandal NS, Ramsey RL, Harvey RJ, Darlison MG, Usherwood PN. Channel gating in the absence of agonist by a homo-oligomeric molluscan GABA receptor expressed in Xenopus oocytes from a cloned cDNA. Invertebrate Neuroscience : In. 1: 267-72. PMID 9372148 DOI: 10.1007/BF02211028 |
0.33 |
|
| 1995 |
Sudan HL, Kerry CJ, Mellor IR, Choi SK, Huang D, Nakanishi K, Usherwood PN. The action of philanthotoxin-343 and photolabile analogues on locust (Schistocerca gregaria) muscle. Invertebrate Neuroscience : In. 1: 159-72. PMID 9372140 DOI: 10.1007/Bf02331913 |
0.418 |
|
| 1993 |
Lerro KA, Orlando R, Zhang H, Usherwood PN, Nakanishi K. Separation of the sticky peptides from membrane proteins by high-performance liquid chromatography in a normal-phase system. Analytical Biochemistry. 215: 38-44. PMID 8297013 DOI: 10.1006/Abio.1993.1551 |
0.308 |
|
| 1993 |
Standley C, Norris TM, Ramsey RL, Usherwood PN. Gating kinetics of the quisqualate-sensitive glutamate receptor of locust muscle studied using agonist concentration jumps and computer simulations. Biophysical Journal. 65: 1379-86. PMID 8274632 DOI: 10.1016/S0006-3495(93)81192-5 |
0.32 |
|
| 1993 |
Brackley PT, Bell DR, Choi SK, Nakanishi K, Usherwood PN. Selective antagonism of native and cloned kainate and NMDA receptors by polyamine-containing toxins. The Journal of Pharmacology and Experimental Therapeutics. 266: 1573-80. PMID 7690404 |
0.472 |
|
| 1993 |
Kerry CJ, Sudan HL, Abutidze K, Mellor IR, Barnard EA, Usherwood PN. Reconstitution of glutamate receptor proteins purified from Xenopus central nervous system into artificial bilayers. Molecular Pharmacology. 44: 142-52. PMID 7688068 |
0.403 |
|
| 1993 |
Brackley PT, Usherwood PN. Are chimeric kainate/N-methyl-D-aspartate receptors expressed in Xenopus oocytes from mammalian and amphibian RNA? The Journal of Pharmacology and Experimental Therapeutics. 265: 910-9. PMID 7684447 |
0.378 |
|
| 1993 |
Usherwood PN, Mellor I, Breedon L, Harvey RJ, Barnard EA, Darlison MG. Channels formed by M2 peptides of a putative glutamate receptor subunit of locust. Exs. 63: 241-9. PMID 7678527 |
0.312 |
|
| 1992 |
Henley JM, Ambrosini A, Rodriguez-Ithurralde D, Sudan H, Brackley P, Kerry C, Mellor I, Abutidze K, Usherwood PN, Barnard EA. Purified unitary kainate/alpha-amino-3-hydroxy-5-methylisooxazole-propionate (AMPA) and kainate/AMPA/N-methyl-D-aspartate receptors with interchangeable subunits. Proceedings of the National Academy of Sciences of the United States of America. 89: 4806-10. PMID 1375752 DOI: 10.1073/Pnas.89.11.4806 |
0.423 |
|
| 1992 |
Usherwood PN, Barnard EA. Evidence for hybrid NMDA/kainate receptors from protein reconstitution studies and expression of vertebrate CNS RNAs in Xenopus oocytes. Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology. 103: 19-22. PMID 1360371 DOI: 10.1016/0742-8413(92)90221-R |
0.437 |
|
| 1992 |
Macdonald AG, Ramsey RL, Shelton CJ, Usherwood PN. Single channel analysis of ketamine interaction with a quisqualate receptor. European Journal of Pharmacology. 210: 223-9. PMID 1351842 DOI: 10.1016/0014-2999(92)90408-V |
0.304 |
|
| 1992 |
Blagbrough IS, Brackley PT, Bruce M, Bycroft BW, Mather AJ, Millington S, Sudan HL, Usherwood PN. Arthropod toxins as leads for novel insecticides: an assessment of polyamine amides as glutamate antagonists. Toxicon : Official Journal of the International Society On Toxinology. 30: 303-22. PMID 1326795 DOI: 10.1016/0041-0101(92)90871-2 |
0.383 |
|
| 1991 |
Brundell P, Goodnow R, Kerry CJ, Nakanishi K, Sudan HL, Usherwood PN. Quisqualate-sensitive glutamate receptors of the locust Schistocerca gregaria are antagonised by intracellularly applied philanthotoxin and spermine. Neuroscience Letters. 131: 196-200. PMID 1722296 DOI: 10.1016/0304-3940(91)90612-W |
0.525 |
|
| 1991 |
Usherwood PN, Blagbrough IS. Spider toxins affecting glutamate receptors: polyamines in therapeutic neurochemistry. Pharmacology & Therapeutics. 52: 245-68. PMID 1667954 DOI: 10.1016/0163-7258(91)90012-B |
0.399 |
|
| 1991 |
Harvey RJ, Vreugdenhil E, Zaman SH, Bhandal NS, Usherwood PN, Barnard EA, Darlison MG. Sequence of a functional invertebrate GABAA receptor subunit which can form a chimeric receptor with a vertebrate alpha subunit. The Embo Journal. 10: 3239-45. PMID 1655414 |
0.302 |
|
| 1991 |
Goodnow RA, Bukownik R, Nakanishi K, Usherwood PN, Eldefrawi AT, Anis NA, Eldefrawi ME. Synthesis and binding of [125I2]philanthotoxin-343, [125I2]philanthotoxin-343-lysine, and [125I2]philanthotoxin-343-arginine to rat brain membranes. Journal of Medicinal Chemistry. 34: 2389-94. PMID 1652018 DOI: 10.1021/Jm00112A012 |
0.463 |
|
| 1991 |
Goodnow RA, Nakanishi K, Sudan HL, Usherwood PN. Inactivation of a quisqualate-sensitive glutamate receptor by photosensitive analogues of philanthotoxin. Neuroscience Letters. 125: 62-4. PMID 1649985 DOI: 10.1016/0304-3940(91)90131-C |
0.506 |
|
| 1990 |
Anis N, Sherby S, Goodnow R, Niwa M, Konno K, Kallimopoulos T, Bukownik R, Nakanishi K, Usherwood P, Eldefrawi A. Structure-activity relationships of philanthotoxin analogs and polyamines on N-methyl-D-aspartate and nicotinic acetylcholine receptors. The Journal of Pharmacology and Experimental Therapeutics. 254: 764-73. PMID 2168484 |
0.465 |
|
| 1990 |
Sansom MS, Usherwood PN. Single-channel studies of glutamate receptors. International Review of Neurobiology. 32: 51-106. PMID 1981887 DOI: 10.1016/S0074-7742(08)60580-2 |
0.426 |
|
| 1990 |
Bruce M, Bukownik R, Eldefrawi AT, Eldefrawi ME, Goodnow R, Kallimopoulos T, Konno K, Nakanishi K, Niwa M, Usherwood PN. Structure-activity relationships of analogues of the wasp toxin philanthotoxin: non-competitive antagonists of quisqualate receptors. Toxicon : Official Journal of the International Society On Toxinology. 28: 1333-46. PMID 1965063 DOI: 10.1016/0041-0101(90)90098-R |
0.519 |
|
| 1990 |
Bates SE, Sansom MS, Ball FG, Ramsey RL, Usherwood PN. Glutamate receptor-channel gating. Maximum likelihood analysis of gigaohm seal recordings from locust muscle. Biophysical Journal. 58: 219-29. PMID 1696510 DOI: 10.1016/S0006-3495(90)82367-5 |
0.301 |
|
| 1990 |
Brackley P, Goodnow R, Nakanishi K, Sudan HL, Usherwood PN. Spermine and philanthotoxin potentiate excitatory amino acid responses of Xenopus oocytes injected with rat and chick brain RNA. Neuroscience Letters. 114: 51-6. PMID 1696366 DOI: 10.1016/0304-3940(90)90427-B |
0.4 |
|
| 1990 |
Nakanishi K, Goodnow R, Konno K, Niwa M, Bukownik R, Thomas T, Kallimopoulos A, Usherwood P, Eldefrawi AT, Eldefrawi ME. Philanthotoxin-433 (PhTX-433), a non-competitive glutamate receptor inhibitor Pure and Applied Chemistry. 62: 1223-1230. DOI: 10.1351/Pac199062071223 |
0.475 |
|
| 1989 |
Dudel J, Franke C, Hatt H, Usherwood PN. Chloride channels gated by extrajunctional glutamate receptors (H-receptors) on locust leg muscle. Brain Research. 481: 215-20. PMID 2470466 DOI: 10.1016/0006-8993(89)90796-8 |
0.405 |
|
| 1988 |
Kerry CJ, Ramsey RL, Sansom MS, Usherwood PN. Glutamate receptor channel kinetics: the effect of glutamate concentration. Biophysical Journal. 53: 39-52. PMID 19431716 DOI: 10.1016/S0006-3495(88)83064-9 |
0.358 |
|
| 1988 |
Eldefrawi AT, Eldefrawi ME, Konno K, Mansour NA, Nakanishi K, Oltz E, Usherwood PN. Structure and synthesis of a potent glutamate receptor antagonist in wasp venom. Proceedings of the National Academy of Sciences of the United States of America. 85: 4910-3. PMID 2838850 DOI: 10.1073/Pnas.85.13.4910 |
0.502 |
|
| 1988 |
Kerry CJ, Ramsey RL, Sansom MS, Usherwood PN. Single channel studies of non-competitive antagonism of a quisqualate-sensitive glutamate receptor by argiotoxin636--a fraction isolated from orb-web spider venom. Brain Research. 459: 312-27. PMID 2460188 DOI: 10.1016/0006-8993(88)90647-6 |
0.348 |
|
| 1987 |
Kerry CJ, Kits KS, Ramsey RL, Sansom MS, Usherwood PN. Single channel kinetics of a glutamate receptor. Biophysical Journal. 51: 137-44. PMID 2436676 DOI: 10.1016/S0006-3495(87)83318-0 |
0.363 |
|
| 1986 |
Kerry CJ, Kits KS, Ramsey RL, Sansom MS, Usherwood PN. Single channel kinetics of a glutamate receptor. Biophysical Journal. 50: 367-74. PMID 19431683 DOI: 10.1016/s0006-3495(86)83470-1 |
0.364 |
|
| 1985 |
Evans ML, Usherwood PN. The effect of lectins on desensitisation of locust muscle glutamate receptors. Brain Research. 358: 34-9. PMID 3000517 DOI: 10.1016/0006-8993(85)90945-X |
0.427 |
|
| 1985 |
Bateman A, Boden P, Dell A, Duce IR, Quicke DL, Usherwood PN. Postsynaptic block of a glutamatergic synapse by low molecular weight fractions of spider venom. Brain Research. 339: 237-44. PMID 2411346 DOI: 10.1016/0006-8993(85)90088-5 |
0.409 |
|
| 1985 |
Usherwood PN, Duce IR. Antagonism of glutamate receptor channel complexes by spider venom polypeptides. Neurotoxicology. 6: 239-49. PMID 2410828 |
0.388 |
|
| 1984 |
Usherwood PN, Duce IR, Boden P. Slowly-reversible block of glutamate receptor-channels by venoms of the spiders, Argiope trifasciata and Araneus gemma. Journal De Physiologie. 79: 241-5. PMID 6099411 |
0.399 |
|
| 1983 |
Donaldson PL, Duce IR, Usherwood PN. Calcium accumulation precedes the degenerative effects of L-glutamate on locust muscle fibres. Brain Research. 274: 261-5. PMID 6138121 DOI: 10.1016/0006-8993(83)90703-5 |
0.303 |
|
| 1983 |
Duce IR, Donaldson PL, Usherwood PN. Investigations into the mechanism of excitant amino acid cytotoxicity using a well-characterized glutamatergic system. Brain Research. 263: 77-87. PMID 6132668 DOI: 10.1016/0006-8993(83)91202-7 |
0.366 |
|
| 1982 |
Clark RB, Donaldson PL, Gration KA, Lambert JJ, Piek T, Ramsey R, Spanjer W, Usherwood PN. Block of locust muscle glutamate receptors by delta-philanthotoxin occurs after receptor activations. Brain Research. 241: 105-14. PMID 6125237 DOI: 10.1016/0006-8993(82)91233-1 |
0.436 |
|
| 1982 |
Gration KA, Lambert JJ, Ramsey RL, Rand RP, Usherwood PN. Closure of membrane channels gated by glutamate receptors may be a two-step process. Nature. 295: 599-603. PMID 6120466 DOI: 10.1038/295599a0 |
0.35 |
|
| 1981 |
Anis NA, Clark RB, Gration KA, Usherwood PN. Influence of agonists on desensitization of glutamate receptors on locust muscle. The Journal of Physiology. 312: 345-64. PMID 7264998 |
0.348 |
|
| 1981 |
Gration KA, Lambert JJ, Ramsey RL, Rand RP, Usherwood PN. Agonist potency determination by patch clamp analysis of single glutamate receptors. Brain Research. 230: 400-5. PMID 6119138 DOI: 10.1016/0006-8993(81)90423-6 |
0.435 |
|
| 1981 |
Gration KA, Lambert JJ, Ramsey R, Usherwood PN. Non-random openings and concentration-dependent lifetimes of glutamate-gated channels in muscle membrane. Nature. 291: 423-5. PMID 6113544 DOI: 10.1038/291423a0 |
0.317 |
|
| 1981 |
Usherwood PN. Glutamate synapses and receptors on insect muscle Advances in Biochemical Psychopharmacology. 27: 183-193. PMID 6108693 |
0.377 |
|
| 1978 |
Mathers DA, Usherwood PN. Effects of concanavalin A on junctional and extrajunctional L-glutamate receptors on locust skeletal muscle fibres. Comparative Biochemistry and Physiology. C: Comparative Pharmacology. 59: 151-5. PMID 25739 DOI: 10.1016/0306-4492(78)90046-1 |
0.35 |
|
| 1974 |
Lea TJ, Usherwood PN. The site of action of ibotenic acid and the identification of two populations of glutamate receptors on insect muscle-fibres. Comparative and General Pharmacology. 4: 333-50. PMID 4799403 DOI: 10.1016/0010-4035(73)90045-1 |
0.352 |
|
| 1973 |
Cull-Candy SG, Usherwood PN. Two populations of L-glutamate receptors on locust muscle fibres. Nature: New Biology. 246: 62-4. PMID 4519031 DOI: 10.1038/newbio246062a0 |
0.326 |
|
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