| Year |
Citation |
Score |
| 2023 |
Olson KM, Devereaux AL, Chatterjee P, Saldaña-Shumaker SL, Shafer A, Plotkin A, Kandasamy R, MacKerell AD, Traynor JR, Cunningham CW. Nitro-benzylideneoxymorphone, a bifunctional mu and delta opioid receptor ligand with high mu opioid receptor efficacy. Frontiers in Pharmacology. 14: 1230053. PMID 37469877 DOI: 10.3389/fphar.2023.1230053 |
0.882 |
|
| 2023 |
Chan WKB, Carlson HA, Traynor JR. . Molecular Pharmacology. PMID 36868791 DOI: 10.1124/molpharm.122.000612 |
0.809 |
|
| 2023 |
Traynor JR, Moron JA. Opioid research in the time of the opioid crisis. British Journal of Pharmacology. 180: 793-796. PMID 36813266 DOI: 10.1111/bph.16043 |
0.497 |
|
| 2022 |
Olson KM, Hillhouse TM, Burgess GE, West JL, Hallahan JE, Dripps IJ, Ladetto AG, Rice KC, Jutkiewicz EM, Traynor JR. Delta opioid receptor-mediated antidepressant-like effects of diprenorphine in mice. The Journal of Pharmacology and Experimental Therapeutics. PMID 36456196 DOI: 10.1124/jpet.122.001182 |
0.882 |
|
| 2022 |
Disney A, Olson KM, Shafer AM, Moore SC, Anand JP, Traynor JR, Husbands SM. Opioid Antagonists from the Orvinol Series as Potential Reversal Agents for Opioid Overdose. Acs Chemical Neuroscience. PMID 36223082 DOI: 10.1021/acschemneuro.2c00464 |
0.889 |
|
| 2022 |
Olson KM, Campbell A, Alt A, Traynor JR. Finding the Perfect Fit: Conformational Biosensors to Determine the Efficacy of GPCR Ligands. Acs Pharmacology & Translational Science. 5: 694-709. PMID 36110374 DOI: 10.1021/acsptsci.1c00256 |
0.827 |
|
| 2022 |
Gerak LR, Maguire DR, Cami-Kobeci G, Olson KM, Traynor JR, Husbands SM, France CP, Acevedo L, Belli B, Flynn P. OREX-1038: a potential new treatment for pain with low abuse liability and limited adverse effects. Behavioural Pharmacology. 33: 377-394. PMID 35947066 DOI: 10.1097/FBP.0000000000000684 |
0.889 |
|
| 2022 |
Chan WKB, Olson KM, Wotring JW, Sexton JZ, Carlson HA, Traynor JR. In silico analysis of SARS-CoV-2 proteins as targets for clinically available drugs. Scientific Reports. 12: 5320. PMID 35351926 DOI: 10.1038/s41598-022-08320-y |
0.763 |
|
| 2021 |
Olson KM, Traynor JR, Alt A. Allosteric Modulator Leads Hiding in Plain Site: Developing Peptide and Peptidomimetics as GPCR Allosteric Modulators. Frontiers in Chemistry. 9: 671483. PMID 34692635 DOI: 10.3389/fchem.2021.671483 |
0.785 |
|
| 2021 |
Chan WKB, DasGupta D, Carlson HA, Traynor JR. Mixed-solvent molecular dynamics simulation-based discovery of a putative allosteric site on regulator of G protein signaling 4. Journal of Computational Chemistry. PMID 34494289 DOI: 10.1002/jcc.26747 |
0.736 |
|
| 2021 |
Traynor JR. Reply to Zhuang et al.: Potential side effects of positive allosteric modulators of the mu-opioid receptor. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34260391 DOI: 10.1073/pnas.2108493118 |
0.462 |
|
| 2021 |
Hillhouse TM, Olson K, Hallahan JE, Rysztak LG, Sears BF, Meurice C, Ostovar M, Koppenhaver PO, West J, Jutkiewicz EM, Husbands SM, Traynor JR. The Journal of Pharmacology and Experimental Therapeutics. PMID 34183434 DOI: 10.1124/jpet.121.000524 |
0.827 |
|
| 2021 |
Bouchet CA, McPherson KB, Li MH, Traynor JR, Ingram SL. . Molecular Pharmacology. PMID 34135098 DOI: 10.1124/molpharm.121.000249 |
0.458 |
|
| 2021 |
Kandasamy R, Hillhouse TM, Livingston KE, Kochan KE, Meurice C, Eans SO, Li MH, White AD, Roques BP, McLaughlin JP, Ingram SL, Burford NT, Alt A, Traynor JR. Positive allosteric modulation of the mu-opioid receptor produces analgesia with reduced side effects. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33846240 DOI: 10.1073/pnas.2000017118 |
0.871 |
|
| 2020 |
Henry S, Anand JP, Brinkel AC, McMillan DM, Twarozynski JJ, Loo CE, Traynor JR, Mosberg HI. SAR Matrices Enable Discovery of Mixed Efficacy μ-Opioid Receptor Agonist Peptidomimetics with Simplified Structures through an Aromatic-Amine Pharmacophore. Acs Chemical Neuroscience. PMID 33346631 DOI: 10.1021/acschemneuro.0c00693 |
0.847 |
|
| 2020 |
Huang W, Manglik A, Venkatakrishnan AJ, Laeremans T, Feinberg EN, Sanborn AL, Kato HE, Livingston KE, Thorsen TS, Kling RC, Granier S, Gmeiner P, Husbands SM, Traynor JR, Weis WI, et al. Author Correction: Structural insights into μ-opioid receptor activation. Nature. PMID 32724208 DOI: 10.1038/S41586-020-2542-Z |
0.59 |
|
| 2020 |
Wang M, Irvin TC, Herdman CA, Hanna RD, Hassan SA, Lee YS, Kaska S, Crowley RS, Prisinzano TE, Withey SL, Paronis CA, Bergman J, Inan S, Geller EB, Adler MW, ... ... Traynor JR, et al. The Intriguing Effects of Substituents in the -Phenethyl Moiety of Norhydromorphone: A Bifunctional Opioid from a Set of "Tail Wags Dog" Experiments. Molecules (Basel, Switzerland). 25. PMID 32517185 DOI: 10.3390/Molecules25112640 |
0.626 |
|
| 2020 |
Dripps IJ, Chen R, Shafer AM, Livingston KE, Disney A, Husbands SM, Traynor JR, Rice KC, Jutkiewicz EM. Pharmacological Properties of Delta Opioid Receptor-Mediated Behaviors: Agonist Efficacy and Receptor Reserve. The Journal of Pharmacology and Experimental Therapeutics. PMID 32467352 DOI: 10.1124/Jpet.119.262717 |
0.576 |
|
| 2020 |
Hassanien SH, Bassman JR, Perrien Naccarato CM, Twarozynski JJ, Traynor JR, Iula DM, Anand JP. In vitro Pharmacology of Fentanyl Analogs at the Human Mu Opioid Receptor and Their Spectroscopic Analysis. Drug Testing and Analysis. PMID 32415719 DOI: 10.1002/Dta.2822 |
0.835 |
|
| 2020 |
Senese NB, Kandasamy R, Kochan KE, Traynor JR. Regulator of G-Protein Signaling (RGS) Protein Modulation of Opioid Receptor Signaling as a Potential Target for Pain Management. Frontiers in Molecular Neuroscience. 13: 5. PMID 32038168 DOI: 10.3389/Fnmol.2020.00005 |
0.843 |
|
| 2020 |
Henry S, Anand JP, Twarozynski JJ, Brinkel AC, Pogozheva ID, Sears BF, Jutkiewicz EM, Traynor JR, Mosberg HI. Aromatic-Amine Pendants Produce Highly Potent and Efficacious Mixed Efficacy Mu-Opioid Receptor (MOR)/Delta-Opioid Receptor (DOR) Peptidomimetics with Enhanced Metabolic Stability. Journal of Medicinal Chemistry. PMID 31986033 DOI: 10.1021/Acs.Jmedchem.9B01818 |
0.859 |
|
| 2020 |
Chan W, Carlson H, Traynor J. Cosolvent Molecular Dynamics Simulation‐Based Discovery of Potential Allosteric Sites on Regulator of G Protein Signaling 4 The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.07054 |
0.724 |
|
| 2020 |
Olson KM, Hillhouse TE, Sears BF, Rysztak L, Husband SM, Jutkiewicz EM, Traynor JR. Buprenorphine Analogs to Treat Relapse The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.06835 |
0.779 |
|
| 2019 |
Montgomery D, Anand JP, Baber MA, Twarozynski JJ, Hartman JG, Delong LJ, Traynor JR, Mosberg HI. Structure-Activity Relationships of 7-Substituted Dimethyltyrosine-Tetrahydroisoquinoline Opioid Peptidomimetics. Molecules (Basel, Switzerland). 24. PMID 31779072 DOI: 10.3390/Molecules24234302 |
0.868 |
|
| 2019 |
Montgomery D, Anand JP, Griggs N, Fernandez TJ, Hartman JG, Sanchez-Santiago AA, Pogozheva ID, Traynor JR, Mosberg HI. Novel Dimethyltyrosine-Tetrahydroisoquinoline Peptidomimetics with Aromatic Tetrahydroisoquinoline Substitutions Show In Vitro Kappa and Mu Opioid Receptor Agonism. Acs Chemical Neuroscience. PMID 31199621 DOI: 10.1021/Acschemneuro.9B00250 |
0.894 |
|
| 2019 |
Henry S, Fernandez TM, Anand JP, Griggs N, Traynor JR, Mosberg HI. Structural Simplification of a Tetrahydroquinoline Core Peptidomimetic µ-Opioid-Receptor (MOR) Agonist/ δ-Opioid Receptor (DOR) Antagonist Produces Improved Metabolic Stability . Journal of Medicinal Chemistry. PMID 30924650 DOI: 10.1021/Acs.Jmedchem.9B00219 |
0.884 |
|
| 2019 |
Nastase AF, Anand JP, Bender AM, Montgomery D, Griggs N, Fernandez TJ, Jutkiewicz EM, Traynor JR, Mosberg HI. Dual Pharmacophores Explored via Structure-Activity Relationship (SAR) Matrix: Insights into Potent, Bifunctional Opioid Ligand Design. Journal of Medicinal Chemistry. PMID 30916966 DOI: 10.1021/Acs.Jmedchem.9B00378 |
0.888 |
|
| 2019 |
Stanczyk MA, Livingston KE, Chang L, Weinberg Z, Puthenveedu M, Traynor JR. The delta opioid receptor positive allosteric modulator BMS 986187 is a G protein biased allosteric agonist. British Journal of Pharmacology. PMID 30710458 DOI: 10.1111/Bph.14602 |
0.782 |
|
| 2019 |
Borsodi A, Bruchas M, Caló G, Chavkin C, Christie MJ, Civelli O, Connor M, Cox BM, Devi LA, Evans C, Höllt V, Henderson G, Husbands S, Kelly E, Kieffer B, ... ... Traynor JR, et al. Opioid receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Iuphar/Bps Guide to Pharmacology Cite. 2019. DOI: 10.2218/gtopdb/f50/2019.4 |
0.635 |
|
| 2019 |
Kandasamy R, Senese N, Chadderdon A, Kohut K, Jutkiewicz E, Ingram S, Traynor J. Loss of RGS Control at Gα
o
Reveals a Balance Between Nociceptin and Mu‐opioid Receptor Systems The Faseb Journal. 33. DOI: 10.1096/Fasebj.2019.33.1_Supplement.669.12 |
0.774 |
|
| 2018 |
Senese NB, Oginsky M, Neubig RR, Ferrario C, Jutkiewicz EM, Traynor JR. Role of hippocampal 5-HT1A receptors in the antidepressant-like phenotype of mice expressing RGS-insensitive Gαi2 protein. Neuropharmacology. 141: 296-304. PMID 30189184 DOI: 10.1016/J.Neuropharm.2018.09.002 |
0.37 |
|
| 2018 |
McPherson KB, Leff ER, Li MH, Meurice C, Tai S, Traynor JR, Ingram SL. Regulators of G protein Signaling (RGS) proteins promote receptor coupling to G protein-coupled inwardly-rectifying potassium (GIRK) channels. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 30150362 DOI: 10.1523/Jneurosci.0516-18.2018 |
0.584 |
|
| 2018 |
Livingston KE, Mahoney JP, Manglik A, Sunahara R, Traynor JR. Measuring ligand efficacy at the mu-opioid receptor using a conformational biosensor. Elife. 7. PMID 29932421 DOI: 10.7554/Elife.32499 |
0.586 |
|
| 2018 |
Nastase AF, Griggs NW, Anand JP, Fernandez TJ, Harland AA, Trask TJ, Jutkiewicz EM, Traynor JR, Mosberg HI. Synthesis and pharmacological evaluation of novel C-8 substituted tetrahydroquinolines as balanced-affinity mu/delta opioid ligands for the treatment of pain. Acs Chemical Neuroscience. PMID 29677442 DOI: 10.1021/Acschemneuro.8B00139 |
0.883 |
|
| 2018 |
Anand JP, Kochan KE, Nastase AF, Montgomery D, Griggs NW, Traynor JR, Mosberg HI, Jutkiewicz EM. In Vivo Effects of μ Opioid Receptor Agonist/δ Opioid Receptor Antagonist Peptidomimetics Following Acute and Repeated Administration. British Journal of Pharmacology. PMID 29352503 DOI: 10.1111/Bph.14148 |
0.894 |
|
| 2018 |
Livingston KE, Mahoney JP, Manglik A, Sunahara RK, Traynor JR. Author response: Measuring ligand efficacy at the mu-opioid receptor using a conformational biosensor Elife. DOI: 10.7554/Elife.32499.015 |
0.647 |
|
| 2017 |
Dripps IJ, Boyer BT, Neubig RR, Rice KC, Traynor JR, Jutkiewicz EM. Role of signaling molecules in behaviors mediated by the δ-receptor agonist SNC80. British Journal of Pharmacology. PMID 29278419 DOI: 10.1111/Bph.14131 |
0.538 |
|
| 2017 |
Livingston KE, Stanczyk MA, Burford N, Alt A, Canals M, Traynor JR. Pharmacological Evidence for a Putative Conserved Allosteric Site on Opioid Receptors. Molecular Pharmacology. PMID 29233847 DOI: 10.1124/Mol.117.109561 |
0.838 |
|
| 2017 |
Lamberts JT, Rosenthal LD, Jutkiewicz EM, Traynor JR. Role of the guanine nucleotide binding protein, Gαo, in the development of morphine tolerance and dependence. Psychopharmacology. PMID 28971229 DOI: 10.1007/S00213-017-4742-2 |
0.874 |
|
| 2017 |
Harland AA, Pogozheva ID, Griggs NW, Trask TJ, Traynor JR, Mosberg HI. Placement of hydroxy moiety on pendant of peptidomimetic scaffold modulates mu and kappa opioid receptor efficacy. Acs Chemical Neuroscience. PMID 28796483 DOI: 10.1021/Acschemneuro.7B00284 |
0.883 |
|
| 2017 |
Livingston KE, Traynor JR. Allostery at opioid receptors: modulation with small molecule ligands. British Journal of Pharmacology. PMID 28419415 DOI: 10.1111/bph.13823 |
0.716 |
|
| 2017 |
Truong PM, Hassan SA, Lee YS, Kopajtic TA, Katz JL, Chadderdon AM, Traynor JR, Deschamps JR, Jacobson AE, Rice KC. Modulation of opioid receptor affinity and efficacy via N-substitution of 9β-hydroxy-5-(3-hydroxyphenyl)morphan: Synthesis and computer simulation study. Bioorganic & Medicinal Chemistry. PMID 28314512 DOI: 10.1016/J.Bmc.2017.02.064 |
0.311 |
|
| 2016 |
Healy JR, Bezawada P, Griggs NW, Devereaux AL, Matsumoto RR, Traynor JR, Coop A, Cunningham CW. Benzylideneoxymorphone: A new lead for development of bifunctional mu/delta opioid receptor ligands. Bioorganic & Medicinal Chemistry Letters. PMID 28011222 DOI: 10.1016/j.bmcl.2016.11.057 |
0.893 |
|
| 2016 |
Dripps IJ, Wang Q, Neubig RR, Rice KC, Traynor JR, Jutkiewicz EM. The role of regulator of G protein signaling 4 in delta-opioid receptor-mediated behaviors. Psychopharmacology. PMID 27624599 DOI: 10.1007/S00213-016-4432-5 |
0.486 |
|
| 2016 |
Harland AA, Bender AM, Griggs NW, Gao C, Anand JP, Pogozheva ID, Traynor JR, Jutkiewicz EM, Mosberg HI. Effects of N-Substitutions on the Tetrahydroquinoline (THQ) core of Mixed-Efficacy μ-Opioid Receptor (MOR)/ δ-Opioid Receptor (DOR) Ligands. Journal of Medicinal Chemistry. PMID 27148755 DOI: 10.1021/Acs.Jmedchem.6B00308 |
0.892 |
|
| 2015 |
Bender AM, Griggs NW, Gao C, Trask TJ, Traynor JR, Mosberg HI. Rapid Synthesis of Boc-2',6'-dimethyl-l-tyrosine and Derivatives and Incorporation into Opioid Peptidomimetics. Acs Medicinal Chemistry Letters. 6: 1199-203. PMID 26713104 DOI: 10.1021/Acsmedchemlett.5B00344 |
0.867 |
|
| 2015 |
Yao XQ, Malik R, Griggs NW, Skjaerven L, Traynor JR, Sivaramakrishnan S, Grant BJ. Dynamic coupling and allosteric networks in the alpha subunit of heterotrimeric G proteins. The Journal of Biological Chemistry. PMID 26703464 DOI: 10.1016/J.Bpj.2015.11.2306 |
0.774 |
|
| 2015 |
Harland AA, Yeomans L, Griggs NW, Anand JP, Pogozheva ID, Jutkiewicz EM, Traynor JR, Mosberg HI. Further Optimization and Evaluation of Bioavailable, Mixed-Efficacy μ-Opioid Receptor (MOR) Agonists/ δ-Opioid Receptor (DOR) Antagonists: Balancing MOR and DOR Affinities. Journal of Medicinal Chemistry. PMID 26524472 DOI: 10.1021/Acs.Jmedchem.5B01270 |
0.895 |
|
| 2015 |
Bisignano P, Burford NT, Shang Y, Marlow B, Livingston KE, Fenton AM, Rockwell K, Budenholzer L, Traynor JR, Gerritz SW, Alt A, Filizola M. Ligand-Based Discovery of a New Scaffold for Allosteric Modulation of the μ-Opioid Receptor. Journal of Chemical Information and Modeling. PMID 26347990 DOI: 10.1021/Acs.Jcim.5B00388 |
0.653 |
|
| 2015 |
Huang W, Manglik A, Venkatakrishnan AJ, Laeremans T, Feinberg EN, Sanborn AL, Kato HE, Livingston KE, Thorsen TS, Kling RC, Granier S, Gmeiner P, Husbands SM, Traynor JR, Weis WI, et al. Structural insights into µ-opioid receptor activation. Nature. 524: 315-21. PMID 26245379 DOI: 10.1038/Nature14886 |
0.593 |
|
| 2015 |
Bender AM, Griggs NW, Anand JP, Traynor JR, Jutkiewicz EM, Mosberg HI. Asymmetric Synthesis and in Vitro and in Vivo Activity of Tetrahydroquinolines Featuring a Diverse Set of Polar Substitutions at the 6 Position as Mixed-Efficacy μ Opioid Receptor/δ Opioid Receptor Ligands. Acs Chemical Neuroscience. 6: 1428-35. PMID 25938166 DOI: 10.1021/Acschemneuro.5B00100 |
0.887 |
|
| 2015 |
Burford NT, Livingston KE, Canals M, Ryan MR, Budenholzer LM, Han Y, Shang Y, Herbst JJ, O'Connell J, Banks M, Zhang L, Filizola M, Bassoni DL, Wehrman TS, Christopoulos A, ... Traynor JR, et al. Discovery, Synthesis, and Molecular Pharmacology of Selective Positive Allosteric Modulators of the δ-Opioid Receptor. Journal of Medicinal Chemistry. 58: 4220-9. PMID 25901762 DOI: 10.1021/Acs.Jmedchem.5B00007 |
0.626 |
|
| 2015 |
Cueva JP, Roche C, Ostovar M, Kumar V, Clark MJ, Hillhouse TM, Lewis JW, Traynor JR, Husbands SM. C7β-Methyl Analogues of the Orvinols: The Discovery of Kappa Opioid Antagonists with Nociceptin/Orphanin FQ Peptide (NOP) Receptor Partial Agonism and Low, or Zero, Efficacy at Mu Opioid Receptors. Journal of Medicinal Chemistry. 58: 4242-9. PMID 25898137 DOI: 10.1021/Acs.Jmedchem.5B00130 |
0.707 |
|
| 2015 |
Blazer LL, Storaska AJ, Jutkiewicz EM, Turner EM, Calcagno M, Wade SM, Wang Q, Huang XP, Traynor JR, Husbands SM, Morari M, Neubig RR. Selectivity and Anti-Parkinson's Potential of Thiadiazolidinone RGS4 Inhibitors. Acs Chemical Neuroscience. 6: 911-9. PMID 25844489 DOI: 10.1021/Acschemneuro.5B00063 |
0.346 |
|
| 2015 |
Graves SM, Clark MJ, Traynor JR, Hu XT, Napier TC. Nucleus accumbens shell excitability is decreased by methamphetamine self-administration and increased by 5-HT2C receptor inverse agonism and agonism. Neuropharmacology. 89: 113-21. PMID 25229719 DOI: 10.1016/j.neuropharm.2014.09.001 |
0.5 |
|
| 2015 |
Cox BM, Christie MJ, Devi L, Toll L, Traynor JR. Challenges for opioid receptor nomenclature: IUPHAR Review 9. British Journal of Pharmacology. 172: 317-23. PMID 24528283 DOI: 10.1111/Bph.12612 |
0.648 |
|
| 2015 |
Burford NT, Traynor JR, Alt A. Positive allosteric modulators of the μ-opioid receptor: a novel approach for future pain medications. British Journal of Pharmacology. 172: 277-86. PMID 24460691 DOI: 10.1111/bph.12599 |
0.693 |
|
| 2015 |
Shang Y, Yeatman HR, Burford N, Livingston K, Bisignano P, Traynor J, Alt A, Christopoulos A, Canals M, Filizola M. Binding Pockets and Poses of Allosteric Modulators of Opioid Receptors Identified by Metadynamics Biophysical Journal. 108: 4-5. DOI: 10.1016/J.Bpj.2014.11.2274 |
0.566 |
|
| 2014 |
Livingston KE, Traynor JR. Disruption of the Na+ ion binding site as a mechanism for positive allosteric modulation of the mu-opioid receptor. Proceedings of the National Academy of Sciences of the United States of America. 111: 18369-74. PMID 25489080 DOI: 10.1073/pnas.1415013111 |
0.634 |
|
| 2014 |
Ben Haddou T, Malfacini D, Calo G, Aceto MD, Harris LS, Traynor JR, Coop A, Schmidhammer H, Spetea M. Exploring pharmacological activities and signaling of morphinans substituted in position 6 as potent agonists interacting with the μ opioid receptor. Molecular Pain. 10: 48. PMID 25059282 DOI: 10.1186/1744-8069-10-48 |
0.712 |
|
| 2014 |
Kumar V, Clark MJ, Traynor JR, Lewis JW, Husbands SM. Pyrrolo- and pyridomorphinans: non-selective opioid antagonists and delta opioid agonists/mu opioid partial agonists. Bioorganic & Medicinal Chemistry. 22: 4067-72. PMID 24973818 DOI: 10.1016/j.bmc.2014.05.065 |
0.699 |
|
| 2014 |
Wang Q, Terauchi A, Yee CH, Umemori H, Traynor JR. 5-HT1A receptor-mediated phosphorylation of extracellular signal-regulated kinases (ERK1/2) is modulated by regulator of G protein signaling protein 19. Cellular Signalling. 26: 1846-52. PMID 24793302 DOI: 10.1016/j.cellsig.2014.04.017 |
0.436 |
|
| 2014 |
Kumar V, Ridzwan IE, Grivas K, Lewis JW, Clark MJ, Meurice C, Jimenez-Gomez C, Pogozheva I, Mosberg H, Traynor JR, Husbands SM. Selectively promiscuous opioid ligands: discovery of high affinity/low efficacy opioid ligands with substantial nociceptin opioid peptide receptor affinity. Journal of Medicinal Chemistry. 57: 4049-57. PMID 24761755 DOI: 10.1021/Jm401964Y |
0.726 |
|
| 2014 |
Mosberg HI, Yeomans L, Anand JP, Porter V, Sobczyk-Kojiro K, Traynor JR, Jutkiewicz EM. Development of a bioavailable μ opioid receptor (MOPr) agonist, δ opioid receptor (DOPr) antagonist peptide that evokes antinociception without development of acute tolerance. Journal of Medicinal Chemistry. 57: 3148-53. PMID 24641190 DOI: 10.1021/Jm5002088 |
0.856 |
|
| 2014 |
Anand JP, Porter-Barrus VR, Waldschmidt HV, Yeomans L, Pogozheva ID, Traynor JR, Mosberg HI. Translation of structure-activity relationships from cyclic mixed efficacy opioid peptides to linear analogues. Biopolymers. 102: 107-14. PMID 24436042 DOI: 10.1002/Bip.22437 |
0.862 |
|
| 2014 |
Casal-Dominguez JJ, Furkert D, Ostovar M, Teintang L, Clark MJ, Traynor JR, Husbands SM, Bailey SJ. Characterization of BU09059: a novel potent selective κ-receptor antagonist. Acs Chemical Neuroscience. 5: 177-84. PMID 24410326 DOI: 10.1021/cn4001507 |
0.613 |
|
| 2014 |
Bender AM, Clark MJ, Agius MP, Traynor JR, Mosberg HI. Synthesis and evaluation of 4-substituted piperidines and piperazines as balanced affinity μ opioid receptor (MOR) agonist/δ opioid receptor (DOR) antagonist ligands. Bioorganic & Medicinal Chemistry Letters. 24: 548-51. PMID 24365161 DOI: 10.1016/J.Bmcl.2013.12.021 |
0.708 |
|
| 2014 |
Bosse KE, Jutkiewicz EM, Schultz-Kuszak KN, Mabrouk OS, Kennedy RT, Gnegy ME, Traynor JR. Synergistic activity between the delta-opioid agonist SNC80 and amphetamine occurs via a glutamatergic NMDA-receptor dependent mechanism. Neuropharmacology. 77: 19-27. PMID 24035916 DOI: 10.1016/J.Neuropharm.2013.08.027 |
0.798 |
|
| 2013 |
Burford NT, Clark MJ, Wehrman TS, Gerritz SW, Banks M, O'Connell J, Traynor JR, Alt A. Discovery of positive allosteric modulators and silent allosteric modulators of the μ-opioid receptor. Proceedings of the National Academy of Sciences of the United States of America. 110: 10830-5. PMID 23754417 DOI: 10.1073/pnas.1300393110 |
0.699 |
|
| 2013 |
Lamberts JT, Smith CE, Li MH, Ingram SL, Neubig RR, Traynor JR. Differential control of opioid antinociception to thermal stimuli in a knock-in mouse expressing regulator of G-protein signaling-insensitive Gαo protein. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 4369-77. PMID 23467353 DOI: 10.1523/Jneurosci.5470-12.2013 |
0.85 |
|
| 2013 |
Lamberts JT, Traynor JR. Opioid receptor interacting proteins and the control of opioid signaling. Current Pharmaceutical Design. 19: 7333-47. PMID 23448476 DOI: 10.2174/138161281942140105160625 |
0.852 |
|
| 2013 |
Birdsong WT, Arttamangkul S, Clark MJ, Cheng K, Rice KC, Traynor JR, Williams JT. Increased agonist affinity at the μ-opioid receptor induced by prolonged agonist exposure. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 4118-27. PMID 23447620 DOI: 10.1523/Jneurosci.4187-12.2013 |
0.715 |
|
| 2013 |
Greedy BM, Bradbury F, Thomas MP, Grivas K, Cami-Kobeci G, Archambeau A, Bosse K, Clark MJ, Aceto M, Lewis JW, Traynor JR, Husbands SM. Orvinols with mixed kappa/mu opioid receptor agonist activity. Journal of Medicinal Chemistry. 56: 3207-16. PMID 23438330 DOI: 10.1021/Jm301543E |
0.887 |
|
| 2013 |
Mosberg HI, Yeomans L, Harland AA, Bender AM, Sobczyk-Kojiro K, Anand JP, Clark MJ, Jutkiewicz EM, Traynor JR. Opioid peptidomimetics: leads for the design of bioavailable mixed efficacy μ opioid receptor (MOR) agonist/δ opioid receptor (DOR) antagonist ligands. Journal of Medicinal Chemistry. 56: 2139-49. PMID 23419026 DOI: 10.1021/Jm400050Y |
0.869 |
|
| 2013 |
Wang Q, Traynor JR. Modulation of μ-opioid receptor signaling by RGS19 in SH-SY5Y cells. Molecular Pharmacology. 83: 512-20. PMID 23197645 DOI: 10.1124/mol.112.081992 |
0.516 |
|
| 2013 |
Casal-Dominguez JJ, Clark M, Traynor JR, Husbands SM, Bailey SJ. In vivo and in vitro characterization of naltrindole-derived ligands at the κ-opioid receptor. Journal of Psychopharmacology (Oxford, England). 27: 192-202. PMID 23118019 DOI: 10.1177/0269881112464828 |
0.639 |
|
| 2012 |
Moynihan HA, Derrick I, Broadbear JH, Greedy BM, Aceto MD, Harris LS, Purington LC, Thomas MP, Woods JH, Traynor JR, Husbands SM, Lewis JW. Fumaroylamino-4,5-epoxymorphinans and related opioids with irreversible μ opioid receptor antagonist effects. Journal of Medicinal Chemistry. 55: 9868-74. PMID 23043264 DOI: 10.1021/jm301096s |
0.876 |
|
| 2012 |
Anand JP, Purington LC, Pogozheva ID, Traynor JR, Mosberg HI. Modulation of opioid receptor ligand affinity and efficacy using active and inactive state receptor models. Chemical Biology & Drug Design. 80: 763-70. PMID 22882801 DOI: 10.1111/Cbdd.12014 |
0.889 |
|
| 2012 |
Traynor J. μ-Opioid receptors and regulators of G protein signaling (RGS) proteins: From a symposium on new concepts in mu-opioid pharmacology Drug and Alcohol Dependence. 121: 173-180. PMID 22129844 DOI: 10.1016/j.drugalcdep.2011.10.027 |
0.548 |
|
| 2011 |
Purington LC, Sobczyk-Kojiro K, Pogozheva ID, Traynor JR, Mosberg HI. Development and in vitro characterization of a novel bifunctional μ-agonist/δ-antagonist opioid tetrapeptide. Acs Chemical Biology. 6: 1375-81. PMID 21958158 DOI: 10.1021/Cb200263Q |
0.901 |
|
| 2011 |
Roman DL, Traynor JR. Regulators of G protein signaling (RGS) proteins as drug targets: modulating G-protein-coupled receptor (GPCR) signal transduction. Journal of Medicinal Chemistry. 54: 7433-40. PMID 21916427 DOI: 10.1021/Jm101572N |
0.356 |
|
| 2011 |
Lamberts JT, Jutkiewicz EM, Mortensen RM, Traynor JR. μ-Opioid receptor coupling to Gα(o) plays an important role in opioid antinociception. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 2041-53. PMID 21654736 DOI: 10.1038/Npp.2011.91 |
0.825 |
|
| 2011 |
Peckham EM, Graves SM, Jutkiewicz E, Becker JB, Traynor JR. Role of gonadal hormones on mu-opioid-stimulated [³âµS]GTPγS binding and morphine-mediated antinociception in male and female Sprague-Dawley rats. Psychopharmacology. 218: 483-92. PMID 21607564 DOI: 10.1007/S00213-011-2335-Z |
0.539 |
|
| 2011 |
Wang Q, Traynor JR. Opioid-induced down-regulation of RGS4: role of ubiquitination and implications for receptor cross-talk. The Journal of Biological Chemistry. 286: 7854-64. PMID 21209077 DOI: 10.1074/jbc.M110.160911 |
0.636 |
|
| 2011 |
Levitt ES, Purington LC, Traynor JR. Gi/o-coupled receptors compete for signaling to adenylyl cyclase in SH-SY5Y cells and reduce opioid-mediated cAMP overshoot. Molecular Pharmacology. 79: 461-71. PMID 21098043 DOI: 10.1124/Mol.110.064816 |
0.873 |
|
| 2010 |
Pichika R, Jewett DM, Sherman PS, Traynor JR, Husbands SM, Woods JH, Kilbourn MR. Synthesis and in vivo brain distribution of carbon-11-labeled δ-opioid receptor agonists. Nuclear Medicine and Biology. 37: 989-96. PMID 21055630 DOI: 10.1016/J.Nucmedbio.2010.06.002 |
0.505 |
|
| 2010 |
Connor M, Traynor J. Constitutively active μ-opioid receptors. Methods in Enzymology. 484: 445-69. PMID 21036245 DOI: 10.1016/B978-0-12-381298-8.00022-8 |
0.71 |
|
| 2010 |
Talbot JN, Jutkiewicz EM, Graves SM, Clemans CF, Nicol MR, Mortensen RM, Huang X, Neubig RR, Traynor JR. RGS inhibition at G(alpha)i2 selectively potentiates 5-HT1A-mediated antidepressant effects. Proceedings of the National Academy of Sciences of the United States of America. 107: 11086-91. PMID 20534514 DOI: 10.1073/Pnas.1000003107 |
0.383 |
|
| 2010 |
Traynor J. Regulator of G protein-signaling proteins and addictive drugs Annals of the New York Academy of Sciences. 1187: 341-352. PMID 20201861 DOI: 10.1111/j.1749-6632.2009.05150.x |
0.408 |
|
| 2010 |
Talbot JN, Roman DL, Clark MJ, Roof RA, Tesmer JJ, Neubig RR, Traynor JR. Differential modulation of mu-opioid receptor signaling to adenylyl cyclase by regulators of G protein signaling proteins 4 or 8 and 7 in permeabilised C6 cells is Galpha subtype dependent. Journal of Neurochemistry. 112: 1026-34. PMID 20002516 DOI: 10.1111/J.1471-4159.2009.06519.X |
0.551 |
|
| 2009 |
Nieland NP, Rennison D, Broadbear JH, Purington L, Woods JH, Traynor JR, Lewis JW, Husbands SM. 14beta-Arylpropiolylamino-17-cyclopropylmethyl-7,8-dihydronormorphinones and related opioids. Further examples of pseudoirreversible mu opioid receptor antagonists. Journal of Medicinal Chemistry. 52: 6926-30. PMID 19842669 DOI: 10.1021/Jm901074A |
0.854 |
|
| 2009 |
Purington LC, Pogozheva ID, Traynor JR, Mosberg HI. Pentapeptides displaying mu opioid receptor agonist and delta opioid receptor partial agonist/antagonist properties. Journal of Medicinal Chemistry. 52: 7724-31. PMID 19788201 DOI: 10.1021/Jm9007483 |
0.902 |
|
| 2009 |
Ingram SL, Traynor JR. Role of protein kinase C in functional selectivity for desensitization at the mu-opioid receptor: from pharmacological curiosity to therapeutic potential. British Journal of Pharmacology. 158: 154-6. PMID 19719778 DOI: 10.1111/J.1476-5381.2009.00198.X |
0.616 |
|
| 2009 |
Levitt ES, Clark MJ, Jenkins PM, Martens JR, Traynor JR. Differential effect of membrane cholesterol removal on mu- and delta-opioid receptors: a parallel comparison of acute and chronic signaling to adenylyl cyclase. The Journal of Biological Chemistry. 284: 22108-22. PMID 19520863 DOI: 10.1074/Jbc.M109.030411 |
0.857 |
|
| 2009 |
Wang Q, Liu-Chen LY, Traynor JR. Differential modulation of mu- and delta-opioid receptor agonists by endogenous RGS4 protein in SH-SY5Y cells. The Journal of Biological Chemistry. 284: 18357-67. PMID 19416973 DOI: 10.1074/jbc.M109.015453 |
0.697 |
|
| 2009 |
Bradbury FA, Zelnik JC, Traynor JR. G protein independent phosphorylation and internalization of the delta-opioid receptor. Journal of Neurochemistry. 109: 1526-35. PMID 19344370 DOI: 10.1111/J.1471-4159.2009.06082.X |
0.677 |
|
| 2009 |
Moynihan H, Jales AR, Greedy BM, Rennison D, Broadbear JH, Purington L, Traynor JR, Woods JH, Lewis JW, Husbands SM. 14 beta-O-cinnamoylnaltrexone and related dihydrocodeinones are mu opioid receptor partial agonists with predominant antagonist activity. Journal of Medicinal Chemistry. 52: 1553-7. PMID 19253983 DOI: 10.1021/Jm8012272 |
0.886 |
|
| 2009 |
Cami-Kobeci G, Neal AP, Bradbury FA, Purington LC, Aceto MD, Harris LS, Lewis JW, Traynor JR, Husbands SM. Mixed kappa/mu opioid receptor agonists: the 6 beta-naltrexamines. Journal of Medicinal Chemistry. 52: 1546-52. PMID 19253970 DOI: 10.1021/Jm8015552 |
0.886 |
|
| 2009 |
Divin MF, Bradbury FA, Carroll FI, Traynor JR. Neutral antagonist activity of naltrexone and 6beta-naltrexol in naïve and opioid-dependent C6 cells expressing a mu-opioid receptor. British Journal of Pharmacology. 156: 1044-53. PMID 19220294 DOI: 10.1111/J.1476-5381.2008.00035.X |
0.895 |
|
| 2009 |
Traynor JR, Terzi D, Caldarone BJ, Zachariou V. RGS9-2: probing an intracellular modulator of behavior as a drug target. Trends in Pharmacological Sciences. 30: 105-11. PMID 19211160 DOI: 10.1016/j.tips.2008.11.006 |
0.43 |
|
| 2008 |
Brinkerhoff CJ, Traynor JR, Linderman JJ. Collision coupling, crosstalk, and compartmentalization in G-protein coupled receptor systems: can a single model explain disparate results? Journal of Theoretical Biology. 255: 278-86. PMID 18761019 DOI: 10.1016/J.Jtbi.2008.08.003 |
0.434 |
|
| 2008 |
Bosse KE, Jutkiewicz EM, Gnegy ME, Traynor JR. The selective delta opioid agonist SNC80 enhances amphetamine-mediated efflux of dopamine from rat striatum. Neuropharmacology. 55: 755-62. PMID 18602932 DOI: 10.1016/J.Neuropharm.2008.06.017 |
0.798 |
|
| 2008 |
Xie H, Woods JH, Traynor JR, Ko MC. The spinal antinociceptive effects of endomorphins in rats: behavioral and G protein functional studies. Anesthesia and Analgesia. 106: 1873-81. PMID 18499626 DOI: 10.1213/ane.0b013e31817300be |
0.6 |
|
| 2008 |
Cunningham CW, Mercer SL, Hassan HE, Traynor JR, Eddington ND, Coop A. Opioids and efflux transporters. Part 2: P-glycoprotein substrate activity of 3- and 6-substituted morphine analogs. Journal of Medicinal Chemistry. 51: 2316-20. PMID 18311899 DOI: 10.1021/Jm701457J |
0.574 |
|
| 2008 |
Clark MJ, Linderman JJ, Traynor JR. Endogenous regulators of G protein signaling differentially modulate full and partial mu-opioid agonists at adenylyl cyclase as predicted by a collision coupling model. Molecular Pharmacology. 73: 1538-48. PMID 18285510 DOI: 10.1124/mol.107.043547 |
0.542 |
|
| 2008 |
Divin MF, Holden Ko MC, Traynor JR. Comparison of the opioid receptor antagonist properties of naltrexone and 6 beta-naltrexol in morphine-naïve and morphine-dependent mice. European Journal of Pharmacology. 583: 48-55. PMID 18275956 DOI: 10.1016/J.Ejphar.2008.01.004 |
0.888 |
|
| 2008 |
Mercer SL, Shaikh J, Traynor JR, Matsumoto RR, Coop A. Nitrile analogs of meperidine as high affinity and selective sigma-1 receptor ligands. European Journal of Medicinal Chemistry. 43: 1304-8. PMID 17988766 DOI: 10.1016/J.Ejmech.2007.09.026 |
0.517 |
|
| 2008 |
Metcalf MD, Aceto MD, Harris LS, Woods JH, Traynor JR, Coop A, May EL. The influence of esters and carboxylic acids as the N-substituent of opioids. Part 1: Benzomorphans. Bioorganic & Medicinal Chemistry. 16: 869-73. PMID 17962026 DOI: 10.1016/j.bmc.2007.10.030 |
0.444 |
|
| 2008 |
Kilbourn MR, Donnelly D, Husbands S, Greedy B, Woods J, Traynor J. Synthesis and in vivo PET imaging studies with [11C]BU4033, a potential delta opioid imaging agent Neuroimage. 41: T23. DOI: 10.1016/J.Neuroimage.2008.04.197 |
0.381 |
|
| 2007 |
Li Y, Husbands SM, Mahon MF, Traynor JR, Rowan MG. Isolation and chemical modification of clerodane diterpenoids from Salvia species as potential agonists at the kappa-opioid receptor. Chemistry & Biodiversity. 4: 1586-93. PMID 17638340 DOI: 10.1002/cbdv.200790138 |
0.662 |
|
| 2007 |
Li JX, Becker GL, Traynor JR, Gong ZH, France CP. Thienorphine: receptor binding and behavioral effects in rhesus monkeys. The Journal of Pharmacology and Experimental Therapeutics. 321: 227-36. PMID 17220427 DOI: 10.1124/jpet.106.113290 |
0.68 |
|
| 2007 |
Roman DL, Talbot JN, Roof RA, Sunahara RK, Traynor JR, Neubig RR. Identification of small-molecule inhibitors of RGS4 using a high-throughput flow cytometry protein interaction assay. Molecular Pharmacology. 71: 169-75. PMID 17012620 DOI: 10.1124/Mol.106.028670 |
0.378 |
|
| 2007 |
Levitt ES, Traynor JR. Disruption of lipid rafts enhances coupling of G‐proteins to non‐raft associated delta opioid receptors in HEK293 cells The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A430-B |
0.824 |
|
| 2007 |
Bradbury F, Zelnik JC, Traynor JR. G Protein Independent Internalization of delta Opioid Receptors The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A426-B |
0.653 |
|
| 2006 |
Clark MJ, Traynor JR. Mediation of adenylyl cyclase sensitization by PTX-insensitive GalphaoA, Galphai1, Galphai2 or Galphai3. Journal of Neurochemistry. 99: 1494-504. PMID 17230639 DOI: 10.1111/j.1471-4159.2006.04176.x |
0.54 |
|
| 2006 |
Rennison D, Moynihan H, Traynor JR, Lewis JW, Husbands SM. Structural determinants of opioid activity in derivatives of 14-aminomorphinones: effects of changes to the chain linking of the C14-amino group to the aryl ring. Journal of Medicinal Chemistry. 49: 6104-10. PMID 17004724 DOI: 10.1021/Jm060595U |
0.529 |
|
| 2006 |
Nieland NP, Moynihan HA, Carrington S, Broadbear J, Woods JH, Traynor JR, Husbands SM, Lewis JW. Structural determinants of opioid activity in derivatives of 14-aminomorphinones: effect of substitution in the aromatic ring of cinnamoylaminomorphinones and codeinones. Journal of Medicinal Chemistry. 49: 5333-8. PMID 16913723 DOI: 10.1021/jm0604777 |
0.533 |
|
| 2006 |
Lester PA, Traynor JR. Comparison of the in vitro efficacy of mu, delta, kappa and ORL1 receptor agonists and non-selective opioid agonists in dog brain membranes. Brain Research. 1073: 290-6. PMID 16443205 DOI: 10.1016/j.brainres.2005.12.066 |
0.714 |
|
| 2006 |
Clark MJ, Furman CA, Gilson TD, Traynor JR. Comparison of the relative efficacy and potency of mu-opioid agonists to activate Galpha(i/o) proteins containing a pertussis toxin-insensitive mutation. The Journal of Pharmacology and Experimental Therapeutics. 317: 858-64. PMID 16436499 DOI: 10.1124/jpet.105.096818 |
0.655 |
|
| 2006 |
Czermak C, Lehofer M, Liebmann PM, Traynor J. [35S]GTPγS binding at the human dopamine D4 receptor variants hD4.2, hD4.4 and hD4.7 following stimulation by dopamine, epinephrine and norepinephrine European Journal of Pharmacology. 531: 20-24. PMID 16423344 DOI: 10.1016/j.ejphar.2005.11.063 |
0.399 |
|
| 2006 |
Peckham EM, Traynor JR. Comparison of the antinociceptive response to morphine and morphine-like compounds in male and female Sprague-Dawley rats. The Journal of Pharmacology and Experimental Therapeutics. 316: 1195-201. PMID 16291875 DOI: 10.1124/jpet.105.094276 |
0.548 |
|
| 2006 |
Ko MC, Divin MF, Lee H, Woods JH, Traynor JR. Differential in vivo potencies of naltrexone and 6beta-naltrexol in the monkey. The Journal of Pharmacology and Experimental Therapeutics. 316: 772-9. PMID 16258020 DOI: 10.1124/Jpet.105.094409 |
0.824 |
|
| 2006 |
González-Núñez V, Barrallo A, Traynor JR, RodrÃguez RE. Characterization of opioid-binding sites in zebrafish brain. The Journal of Pharmacology and Experimental Therapeutics. 316: 900-4. PMID 16207834 DOI: 10.1124/jpet.105.093492 |
0.574 |
|
| 2005 |
Przydzial MJ, Pogozheva ID, Ho JC, Bosse KE, Sawyer E, Traynor JR, Mosberg HI. Design of high affinity cyclic pentapeptide ligands for kappa-opioid receptors. The Journal of Peptide Research : Official Journal of the American Peptide Society. 66: 255-62. PMID 16218993 DOI: 10.1111/J.1399-3011.2005.00295.X |
0.837 |
|
| 2005 |
Jutkiewicz EM, Rice KC, Traynor JR, Woods JH. Separation of the convulsions and antidepressant-like effects produced by the delta-opioid agonist SNC80 in rats. Psychopharmacology. 182: 588-96. PMID 16163520 DOI: 10.1007/S00213-005-0138-9 |
0.615 |
|
| 2005 |
Peckham EM, Barkley LM, Divin MF, Cicero TJ, Traynor JR. Comparison of the antinociceptive effect of acute morphine in female and male Sprague-Dawley rats using the long-lasting mu-antagonist methocinnamox. Brain Research. 1058: 137-47. PMID 16139823 DOI: 10.1016/J.Brainres.2005.07.060 |
0.854 |
|
| 2005 |
Jutkiewicz EM, Kaminsky ST, Rice KC, Traynor JR, Woods JH. Differential behavioral tolerance to the delta-opioid agonist SNC80 ([(+)-4-[(alphaR)-alpha-[(2S,5R)-2,5-dimethyl-4-(2-propenyl)-1-piperazinyl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide) in Sprague-Dawley rats. The Journal of Pharmacology and Experimental Therapeutics. 315: 414-22. PMID 16014751 DOI: 10.1124/Jpet.105.088831 |
0.602 |
|
| 2005 |
Przydzial MJ, Pogozheva ID, Bosse KE, Andrews SM, Tharp TA, Traynor JR, Mosberg HI. Roles of residues 3 and 4 in cyclic tetrapeptide ligand recognition by the kappa-opioid receptor. The Journal of Peptide Research : Official Journal of the American Peptide Society. 65: 333-42. PMID 15787963 DOI: 10.1111/J.1399-3011.2005.00220.X |
0.867 |
|
| 2005 |
Chauvignac C, Miller CN, Srivastava SK, Lewis JW, Husbands SM, Traynor JR. Major effect of pyrrolic N-benzylation in norbinaltorphimine, the selective kappa-opioid receptor antagonist. Journal of Medicinal Chemistry. 48: 1676-9. PMID 15743210 DOI: 10.1021/Jm049172N |
0.7 |
|
| 2005 |
Traynor JR, Neubig RR. Regulators of G protein signaling & drugs of abuse. Molecular Interventions. 5: 30-41. PMID 15734717 DOI: 10.1124/mi.5.1.7 |
0.348 |
|
| 2005 |
Husbands SM, Neilan CL, Broadbear J, Grundt P, Breeden S, Aceto MD, Woods JH, Lewis JW, Traynor JR. BU74, a complex oripavine derivative with potent kappa opioid receptor agonism and delayed opioid antagonism. European Journal of Pharmacology. 509: 117-25. PMID 15733546 DOI: 10.1016/j.ejphar.2004.12.035 |
0.719 |
|
| 2005 |
Jutkiewicz EM, Walker NP, Folk JE, Rice KC, Portoghese PS, Woods JH, Traynor JR. Comparison of peptidic and nonpeptidic delta-opioid agonists on guanosine 5'-O-(3-[35S]thio)triphosphate ([35S]GTPgammaS) binding in brain slices from Sprague-Dawley rats. The Journal of Pharmacology and Experimental Therapeutics. 312: 1314-20. PMID 15574687 DOI: 10.1124/Jpet.104.078741 |
0.616 |
|
| 2005 |
Clark MJ, Traynor JR. Endogenous regulator of g protein signaling proteins reduce {mu}-opioid receptor desensitization and down-regulation and adenylyl cyclase tolerance in C6 cells. The Journal of Pharmacology and Experimental Therapeutics. 312: 809-15. PMID 15383633 DOI: 10.1124/jpet.104.074641 |
0.642 |
|
| 2004 |
Srivastava SK, Shefali S, Miller CN, Aceto MD, Traynor JR, Lewis JW, Husbands SM. Effects of substitution on the pyrrole N atom in derivatives of tetrahydronaltrindole, tetrahydrooxymorphindole, and a related 4,5-epoxyphenylpyrrolomorphinan. Journal of Medicinal Chemistry. 47: 6645-8. PMID 15588100 DOI: 10.1021/Jm040817T |
0.637 |
|
| 2004 |
Neilan CL, Husbands SM, Breeden S, Ko MC, Aceto MD, Lewis JW, Woods JH, Traynor JR. Characterization of the complex morphinan derivative BU72 as a high efficacy, long-lasting mu-opioid receptor agonist. European Journal of Pharmacology. 499: 107-16. PMID 15363957 DOI: 10.1016/j.ejphar.2004.07.097 |
0.716 |
|
| 2004 |
Clark MJ, Traynor JR. Assays for G-protein-coupled receptor signaling using RGS-insensitive Galpha subunits. Methods in Enzymology. 389: 155-69. PMID 15313565 DOI: 10.1016/S0076-6879(04)89010-4 |
0.42 |
|
| 2004 |
Waller A, Sutton KL, Kinzer-Ursem TL, Absood A, Traynor JR, Linderman JJ, Omann GM. Receptor binding kinetics and cellular responses of six N-formyl peptide agonists in human neutrophils. Biochemistry. 43: 8204-16. PMID 15209517 DOI: 10.1021/Bi035335I |
0.764 |
|
| 2004 |
Romano MA, McNish R, Seymour EM, Traynor JR, Bolling SF. Differential effects of opioid peptides on myocardial ischemic tolerance. The Journal of Surgical Research. 119: 46-50. PMID 15126081 DOI: 10.1016/j.jss.2004.01.006 |
0.586 |
|
| 2004 |
Clark MJ, Neubig RR, Traynor JR. Endogenous regulator of G protein signaling proteins suppress Galphao-dependent, mu-opioid agonist-mediated adenylyl cyclase supersensitization. The Journal of Pharmacology and Experimental Therapeutics. 310: 215-22. PMID 15014136 DOI: 10.1124/jpet.103.064824 |
0.61 |
|
| 2004 |
Jutkiewicz EM, Eller EB, Folk JE, Rice KC, Traynor JR, Woods JH. Delta-opioid agonists: differential efficacy and potency of SNC80, its 3-OH (SNC86) and 3-desoxy (SNC162) derivatives in Sprague-Dawley rats. The Journal of Pharmacology and Experimental Therapeutics. 309: 173-81. PMID 14722329 DOI: 10.1124/Jpet.103.061242 |
0.47 |
|
| 2004 |
Traynor JR. G-Protein Coupling and Efficacy of Mu-Opioid Agonists: Relationship to Behavioral Efficacy Reviews in Analgesia. 8: 11-22. DOI: 10.3727/000000004783992927 |
0.471 |
|
| 2003 |
Black SL, Chauvignac C, Grundt P, Miller CN, Wood S, Traynor JR, Lewis JW, Husbands SM. Guanidino N-substituted and N,N-disubstituted derivatives of the kappa-opioid antagonist GNTI. Journal of Medicinal Chemistry. 46: 5505-11. PMID 14640558 DOI: 10.1021/jm0309203 |
0.645 |
|
| 2003 |
Harrison C, Traynor JR. The [35S]GTPgammaS binding assay: approaches and applications in pharmacology. Life Sciences. 74: 489-508. PMID 14609727 |
0.416 |
|
| 2003 |
Seymour EM, Wu SY, Kovach MA, Romano MA, Traynor JR, Claycomb WC, Bolling SF. HL-1 myocytes exhibit PKC and K(ATP) channel-dependent delta opioid preconditioning. The Journal of Surgical Research. 114: 187-94. PMID 14559445 DOI: 10.1016/S0022-4804(03)00248-8 |
0.43 |
|
| 2003 |
Heyl DL, Schullery SE, Renganathan K, Jayamaha MN, Rodgers DW, Traynor JR. pKa and volume of residue one influence delta/mu opioid binding: QSAR analysis of tyrosine replacement in a nonselective deltorphin analogue. Bioorganic & Medicinal Chemistry. 11: 3761-8. PMID 12901921 DOI: 10.1016/S0968-0896(03)00329-8 |
0.637 |
|
| 2003 |
Greiner E, Spetea M, Krassnig R, Schüllner F, Aceto M, Harris LS, Traynor JR, Woods JH, Coop A, Schmidhammer H. Synthesis and biological evaluation of 14-alkoxymorphinans. 18. N-substituted 14-phenylpropyloxymorphinan-6-ones with unanticipated agonist properties: extending the scope of common structure-activity relationships. Journal of Medicinal Chemistry. 46: 1758-63. PMID 12699394 DOI: 10.1021/jm021118o |
0.599 |
|
| 2003 |
Ko MC, Lee H, Harrison C, Clark MJ, Song HF, Naughton NN, Woods JH, Traynor JR. Studies of micro-, kappa-, and delta-opioid receptor density and G protein activation in the cortex and thalamus of monkeys. The Journal of Pharmacology and Experimental Therapeutics. 306: 179-86. PMID 12676881 DOI: 10.1124/jpet.103.050625 |
0.598 |
|
| 2003 |
Grundt P, Jales AR, Traynor JR, Lewis JW, Husbands SM. 14-amino, 14-alkylamino, and 14-acylamino analogs of oxymorphindole. Differential effects on opioid receptor binding and functional profiles. Journal of Medicinal Chemistry. 46: 1563-6. PMID 12672258 DOI: 10.1021/jm021073r |
0.616 |
|
| 2003 |
Clark MJ, Harrison C, Zhong H, Neubig RR, Traynor JR. Endogenous RGS protein action modulates mu-opioid signaling through Galphao. Effects on adenylyl cyclase, extracellular signal-regulated kinases, and intracellular calcium pathways. The Journal of Biological Chemistry. 278: 9418-25. PMID 12524446 DOI: 10.1074/jbc.M208885200 |
0.534 |
|
| 2003 |
May EL, Coop A, Woods JH, Aceto MD, Bowman ER, Harris LS, Traynor JR. N-(trifluoromethyl)benzyl substituted N-normetazocines and N-norketobemidones. Bioorganic & Medicinal Chemistry. 11: 31-3. PMID 12467704 DOI: 10.1016/S0968-0896(02)00435-2 |
0.523 |
|
| 2003 |
Zhong H, Wade SM, Woolf PJ, Linderman JJ, Traynor JR, Neubig RR. A spatial focusing model for G protein signals. Regulator of G protein signaling (RGS) protien-mediated kinetic scaffolding. The Journal of Biological Chemistry. 278: 7278-84. PMID 12446706 DOI: 10.1074/Jbc.M208819200 |
0.378 |
|
| 2002 |
Broom DC, Jutkiewicz EM, Rice KC, Traynor JR, Woods JH. Behavioral effects of delta-opioid receptor agonists: potential antidepressants? Japanese Journal of Pharmacology. 90: 1-6. PMID 12396021 DOI: 10.1254/Jjp.90.1 |
0.689 |
|
| 2002 |
Broom DC, Nitsche JF, Pintar JE, Rice KC, Woods JH, Traynor JR. Comparison of receptor mechanisms and efficacy requirements for delta-agonist-induced convulsive activity and antinociception in mice. The Journal of Pharmacology and Experimental Therapeutics. 303: 723-9. PMID 12388657 DOI: 10.1124/Jpet.102.036525 |
0.648 |
|
| 2002 |
Broom DC, Jutkiewicz EM, Folk JE, Traynor JR, Rice KC, Woods JH. Convulsant activity of a non-peptidic delta-opioid receptor agonist is not required for its antidepressant-like effects in Sprague-Dawley rats. Psychopharmacology. 164: 42-8. PMID 12373418 DOI: 10.1007/S00213-002-1179-Y |
0.604 |
|
| 2002 |
Broom DC, Jutkiewicz EM, Folk JE, Traynor JR, Rice KC, Woods JH. Nonpeptidic delta-opioid receptor agonists reduce immobility in the forced swim assay in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 26: 744-55. PMID 12007745 DOI: 10.1016/S0893-133X(01)00413-4 |
0.557 |
|
| 2002 |
Ko MC, Naughton NN, Traynor JR, Song MS, Woods JH, Rice KC, McKnight AT. Orphanin FQ inhibits capsaicin-induced thermal nociception in monkeys by activation of peripheral ORL1 receptors. British Journal of Pharmacology. 135: 943-50. PMID 11861322 DOI: 10.1038/Sj.Bjp.0704535 |
0.643 |
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| 2002 |
Alt A, Clark MJ, Woods JH, Traynor JR. Mu and Delta opioid receptors activate the same G proteins in human neuroblastoma SH-SY5Y cells. British Journal of Pharmacology. 135: 217-25. PMID 11786497 DOI: 10.1038/Sj.Bjp.0704430 |
0.608 |
|
| 2002 |
Srivastava SK, Husbands SM, Aceto MD, Miller CN, Traynor JR, Lewis JW. 4'-Arylpyrrolomorphinans: effect of a pyrrolo-N-benzyl substituent in enhancing delta-opioid antagonist activity. Journal of Medicinal Chemistry. 45: 537-40. PMID 11784158 DOI: 10.1021/Jm010841W |
0.499 |
|
| 2002 |
Traynor JR, Clark MJ, Remmers AE. Relationship between rate and extent of G protein activation: comparison between full and partial opioid agonists. The Journal of Pharmacology and Experimental Therapeutics. 300: 157-61. PMID 11752111 DOI: 10.1124/jpet.300.1.157 |
0.615 |
|
| 2001 |
Butelman ER, Ko MC, Traynor JR, Vivian JA, Kreek MJ, Woods JH. GR89,696: a potent kappa-opioid agonist with subtype selectivity in rhesus monkeys. The Journal of Pharmacology and Experimental Therapeutics. 298: 1049-59. PMID 11504802 |
0.598 |
|
| 2001 |
Alt A, McFadyen IJ, Fan CD, Woods JH, Traynor JR. Stimulation of guanosine-5'-o-(3-[35S]thio)triphosphate binding in digitonin-permeabilized C6 rat glioma cells: evidence for an organized association of mu-opioid receptors and G protein. The Journal of Pharmacology and Experimental Therapeutics. 298: 116-21. PMID 11408532 |
0.598 |
|
| 2000 |
May EL, Jacobson AE, Mattson MV, Traynor JR, Woods JH, Harris LS, Bowman ER, Aceto MD. Synthesis and in vitro and in vivo activity of (-)-(1R,5R,9R)- and (+)-(1S,5S,9S)-N-alkenyl-, -N-alkynyl-, and -N-cyanoalkyl-5, 9-dimethyl-2'-hydroxy-6,7-benzomorphan homologues. Journal of Medicinal Chemistry. 43: 5030-6. PMID 11150174 DOI: 10.1021/jm000317 |
0.42 |
|
| 2000 |
Neilan CL, Kenyon E, Kovach MA, Bowden K, Claycomb WC, Traynor JR, Bolling SF. An immortalized myocyte cell line, HL-1, expresses a functional delta -opioid receptor. Journal of Molecular and Cellular Cardiology. 32: 2187-93. PMID 11112994 DOI: 10.1006/jmcc.2000.1241 |
0.64 |
|
| 2000 |
McFadyen IJ, Sobczyk-Kojiro K, Schaefer MJ, Ho JC, Omnaas JR, Mosberg HI, Traynor JR. Tetrapeptide derivatives of [D-Pen(2),D-Pen(5)]-enkephalin (DPDPE) lacking an N-terminal tyrosine residue are agonists at the mu-opioid receptor. The Journal of Pharmacology and Experimental Therapeutics. 295: 960-6. PMID 11082429 |
0.468 |
|
| 2000 |
Coop A, Jacobson AE, Aceto MD, Harris LS, Traynor JR, Woods JH, Rice KC. N-Cyclohexylethyl-N-noroxymorphindole: a mu-opioid preferring analogue of naltrindole. Bioorganic & Medicinal Chemistry Letters. 10: 2449-51. PMID 11078198 DOI: 10.1016/S0960-894X(00)00479-0 |
0.573 |
|
| 2000 |
McFadyen IJ, Houshyar H, Liu-Chen LY, Woods JH, Traynor JR. The steroid 17alpha-acetoxy-6-dimethylaminomethyl-21-fluoro-3-ethoxy-pregna-3, 5-dien-20-one (SC17599) is a selective mu-opioid agonist: implications for the mu-opioid pharmacophore. Molecular Pharmacology. 58: 669-76. PMID 10999935 DOI: 10.1124/Mol.58.4.669 |
0.717 |
|
| 2000 |
Derrick I, Neilan CL, Andes J, Husbands SM, Woods JH, Traynor JR, Lewis JW. 3-Deoxyclocinnamox: the first high-affinity, nonpeptide mu-opioid antagonist lacking a phenolic hydroxyl group. Journal of Medicinal Chemistry. 43: 3348-50. PMID 10966754 DOI: 10.1021/Jm0009641 |
0.634 |
|
| 2000 |
Broom DC, Guo L, Coop A, Husbands SM, Lewis JW, Woods JH, Traynor JR. BU48: a novel buprenorphine analog that exhibits delta-opioid-mediated convulsions but not delta-opioid-mediated antinociception in mice. The Journal of Pharmacology and Experimental Therapeutics. 294: 1195-200. PMID 10945877 |
0.629 |
|
| 2000 |
Broadbear JH, Sumpter TL, Burke TF, Husbands SM, Lewis JW, Woods JH, Traynor JR. Methocinnamox is a potent, long-lasting, and selective antagonist of morphine-mediated antinociception in the mouse: comparison with clocinnamox, beta-funaltrexamine, and beta-chlornaltrexamine. The Journal of Pharmacology and Experimental Therapeutics. 294: 933-40. PMID 10945843 |
0.404 |
|
| 2000 |
Rodriguez RE, Barrallo A, Garcia-Malvar F, McFadyen IJ, Gonzalez-Sarmiento R, Traynor JR. Characterization of ZFOR1, a putative delta-opioid receptor from the teleost zebrafish (Danio rerio). Neuroscience Letters. 288: 207-10. PMID 10889344 DOI: 10.1016/S0304-3940(00)01239-8 |
0.707 |
|
| 2000 |
Remmers AE, Clark MJ, Alt A, Medzihradsky F, Woods JH, Traynor JR. Activation of G protein by opioid receptors: role of receptor number and G-protein concentration. European Journal of Pharmacology. 396: 67-75. PMID 10822058 DOI: 10.1016/S0014-2999(00)00212-0 |
0.633 |
|
| 2000 |
Houshyar H, Mc Fadyen IJ, Woods JH, Traynor JR. Antinociceptive and other behavioral effects of the steroid SC17599 are mediated by the mu-opioid receptor. European Journal of Pharmacology. 395: 121-8. PMID 10794817 DOI: 10.1016/S0014-2999(00)00176-X |
0.684 |
|
| 2000 |
McFadyen IJ, Ho JC, Mosberg HI, Traynor JR. Modifications of the cyclic mu receptor selective tetrapeptide Tyr-c[D-Cys-Phe-D-Pen]NH2 (Et): effects on opioid receptor binding and activation. The Journal of Peptide Research : Official Journal of the American Peptide Society. 55: 255-61. PMID 10727108 DOI: 10.1034/J.1399-3011.2000.00177.X |
0.67 |
|
| 2000 |
Derrick I, Husbands SM, Broadbear J, Traynor JR, Woods JH, Lewis JW. Cinnamoyl derivatives of 7a-amino- and 7a-(aminomethyl)- N-(cyclopropylmethyl)-6,14-endo-ethanotetrahydronororipavines are high-potency opioid antagonists Helvetica Chimica Acta. 83: 3122-3130. DOI: 10.1002/1522-2675(20001220)83:12<3122::Aid-Hlca3122>3.0.Co;2-2 |
0.515 |
|
| 2000 |
Coop A, Berzetei-Gurske I, Burnside J, Toll L, Traynor JR, Husbands SM, Lewis JW. Structural determinants of opioid activity in the orvinols and related structures. Ethers of 7,8-cyclopenta-fused analogs of buprenorphine Helvetica Chimica Acta. 83: 687-693. DOI: 10.1002/(Sici)1522-2675(20000412)83:4<687::Aid-Hlca687>3.0.Co;2-W |
0.552 |
|
| 1999 |
Márki A, Monory K, Otvös F, Tóth G, Krassnig R, Schmidhammer H, Traynor JR, Roques BP, Maldonado R, Borsodi A. Mu-opioid receptor specific antagonist cyprodime: characterization by in vitro radioligand and [35S]GTPgammaS binding assays. European Journal of Pharmacology. 383: 209-14. PMID 10585536 DOI: 10.1016/S0014-2999(99)00610-X |
0.646 |
|
| 1999 |
Traynor JR, Guo L, Coop A, Lewis JW, Woods JH. Ring-constrained orvinols as analogs of buprenorphine: differences in opioid activity related to configuration of C(20) hydroxyl group. The Journal of Pharmacology and Experimental Therapeutics. 291: 1093-9. PMID 10565829 |
0.559 |
|
| 1999 |
Neilan CL, Akil H, Woods JH, Traynor JR. Constitutive activity of the delta-opioid receptor expressed in C6 glioma cells: identification of non-peptide delta-inverse agonists. British Journal of Pharmacology. 128: 556-62. PMID 10516632 DOI: 10.1038/sj.bjp.0702816 |
0.654 |
|
| 1999 |
Lee KO, Akil H, Woods JH, Traynor JR. Differential binding properties of oripavines at cloned mu- and delta-opioid receptors. European Journal of Pharmacology. 378: 323-30. PMID 10493109 DOI: 10.1016/S0014-2999(99)00460-4 |
0.715 |
|
| 1999 |
Johnson MD, Ko M, Choo KS, Traynor JR, Mosberg HI, Naughton NN, Woods JH. The effects of the phyllolitorin analogue [desTrp(3), Leu(8)]phyllolitorin on scratching induced by bombesin and related peptides in rats. Brain Research. 839: 194-8. PMID 10482814 DOI: 10.1016/S0006-8993(99)01708-4 |
0.347 |
|
| 1999 |
Vivian JA, DeYoung MB, Sumpter TL, Traynor JR, Lewis JW, Woods JH. kappa-Opioid receptor effects of butorphanol in rhesus monkeys. The Journal of Pharmacology and Experimental Therapeutics. 290: 259-65. PMID 10381785 |
0.622 |
|
| 1998 |
Barrallo A, Malvar FG, Gonzalez R, Rodriguez RE, Traynor JR. Cloning and characterization of a delta opioid receptor from zebrafish. Biochemical Society Transactions. 26: S360. PMID 10047874 DOI: 10.1042/Bst026S360 |
0.693 |
|
| 1998 |
Wang C, McFadyen IJ, Traynor JR, Mosberg HI. Design of a high affinity peptidomimetic opioid agonist from peptide pharmacophore models. Bioorganic & Medicinal Chemistry Letters. 8: 2685-8. PMID 9873603 DOI: 10.1016/S0960-894X(98)00472-7 |
0.711 |
|
| 1998 |
Husbands SM, Sadd J, Broadbear JH, Woods JH, Martin J, Traynor JR, Aceto MD, Bowman ER, Harris LS, Lewis JW. 3-Alkyl ethers of clocinnamox: delayed long-term mu-antagonists with variable mu efficacy. Journal of Medicinal Chemistry. 41: 3493-8. PMID 9719602 DOI: 10.1021/Jm9810248 |
0.684 |
|
| 1998 |
Woods JH, Medzihradsky F, Smith CB, Winger G, Traynor JR. Evaluation of new compounds for opioid activity (1997). Nida Research Monograph. 178: 408-28. PMID 9686405 |
0.429 |
|
| 1998 |
Bell KM, Traynor JR. Dynorphin A(1-8): stability and implications for in vitro opioid activity. Canadian Journal of Physiology and Pharmacology. 76: 325-33. PMID 9673796 DOI: 10.1139/cjpp-76-3-325 |
0.626 |
|
| 1998 |
Alt A, Mansour A, Akil H, Medzihradsky F, Traynor JR, Woods JH. Stimulation of guanosine-5'-O-(3-[35S]thio)triphosphate binding by endogenous opioids acting at a cloned mu receptor. The Journal of Pharmacology and Experimental Therapeutics. 286: 282-8. PMID 9655870 |
0.612 |
|
| 1998 |
Ko MC, Butelman ER, Traynor JR, Woods JH. Differentiation of kappa opioid agonist-induced antinociception by naltrexone apparent pA2 analysis in rhesus monkeys. The Journal of Pharmacology and Experimental Therapeutics. 285: 518-26. PMID 9580592 |
0.635 |
|
| 1998 |
Schmidhammer H, Krassnig R, Greiner E, Traynor JR. Synthesis and Biological Evaluation of 14-Alkoxymorphinans. 16. 14-O-Alkyl Derivatives of the m-Opioid Receptor Antagonist Cyprodime Heterocycles. 49: 489-497. DOI: 10.3987/Com-98-S60 |
0.581 |
|
| 1998 |
Hong EJ, Rice KC, Calderon S, Woods JH, Traynor JR. Convulsive Behavior of Nonpeptide δ-Opioid Ligands:Comparison of SNC80 and BW373U86 in Mice Analgesia. 3: 269-276. DOI: 10.3727/107156998819565947 |
0.427 |
|
| 1998 |
Schmidhammer H, Krassnig R, Greiner E, Traynor JR. Synthesis and biological evaluation of 14-alkoxymorphinans. 16.1 14-0-alkyl derivatives of the μ opioid receptor antagonist cyprodime Heterocycles. 49: 489-497. |
0.6 |
|
| 1997 |
Szekeres PG, Traynor JR. Delta opioid modulation of the binding of guanosine-5'-O-(3-[35S]thio)triphosphate to NG108-15 cell membranes: characterization of agonist and inverse agonist effects. The Journal of Pharmacology and Experimental Therapeutics. 283: 1276-84. PMID 9400003 |
0.502 |
|
| 1997 |
Elliott J, Guo L, Traynor JR. Tolerance to mu-opioid agonists in human neuroblastoma SH-SY5Y cells as determined by changes in guanosine-5'-O-(3-[35S]-thio)triphosphate binding. British Journal of Pharmacology. 121: 1422-8. PMID 9257923 DOI: 10.1038/sj.bjp.0701253 |
0.621 |
|
| 1997 |
Schmidhammer H, Daurer D, Wieser M, Monory K, Borsodi A, Elliott J, Traynor JR. Synthesis and biological evaluation of 14-alkoxymorphinans. XIV. 14-Ethoxy-5-methyl substituted indolomorphinans with δ opioid receptor selectivity Bioorganic and Medicinal Chemistry Letters. 7: 151-156. DOI: 10.1016/S0960-894X(96)00599-9 |
0.515 |
|
| 1996 |
Traynor J. Painless reading The pharmacology of opioid peptides Trends in Pharmacological Sciences. 17: 234. DOI: 10.1016/0165-6147(96)81603-8 |
0.42 |
|
| 1996 |
Traynor JR. The μ-opioid receptor Pain Reviews. 3: 221-248. |
0.64 |
|
| 1995 |
Elliott J, Traynor JR. Evidence for lack of modulation of mu-opioid agonist action by delta-opioid agonists in the mouse vas deferens and guinea-pig ileum. British Journal of Pharmacology. 114: 1064-8. PMID 7780641 DOI: 10.1111/j.1476-5381.1995.tb13314.x |
0.632 |
|
| 1995 |
Traynor JR, Nahorski SR. Modulation by mu-opioid agonists of guanosine-5'-O-(3-[35S]thio)triphosphate binding to membranes from human neuroblastoma SH-SY5Y cells. Molecular Pharmacology. 47: 848-54. PMID 7723747 |
0.602 |
|
| 1995 |
Schmidhammer H, Jennewein HK, Krassnig R, Traynor JR, Patel D, Bell K, Froschauer G, Mattersberger K, Jachs-Ewinger C, Jura P. Synthesis and biological evaluation of 14-alkoxymorphinans. 11. 3-Hydroxycyprodime and analogues: opioid antagonist profile in comparison to cyprodime. Journal of Medicinal Chemistry. 38: 3071-7. PMID 7636870 |
0.632 |
|
| 1995 |
Guo L, Coop A, Lewis JW, Traynor JR. AFFINITY AND EFFICACY STUDIES OF RING CONSTRAINED ANALOGUES OF BUPRENORPHINE AT μ-OPIOID RECEPTORS. Analgesia. 1: 450-452. DOI: 10.3727/107156995819563915 |
0.613 |
|
| 1995 |
Szekeres PG, Traynor JR. δ-OPIOIDS STIMULATE [35S]GTPγS BINDING IN MEMBRANES FROM NG108-15 NEUROBLASTOMA x GLIOMA CELLS Analgesia. 1: 778-780. DOI: 10.3727/107156995819563717 |
0.339 |
|
| 1995 |
Schmidhammer H, Stangl A, Fürst Z, Szabó E, Borsodi A, Patel D, Traynor JR. Synthesis and biological evaluation of 14-alkoxymorphinans.12.1 A phenethyl analogue of the μ-selective opioid receptor antagonist cyprodime Bioorganic and Medicinal Chemistry Letters. 5: 1923-1926. DOI: 10.1016/0960-894X(95)00325-N |
0.592 |
|
| 1994 |
Rupniak NM, Patel S, Marwood R, Webb J, Traynor JR, Elliott J, Freedman SB, Fletcher SR, Hill RG. Antinociceptive and toxic effects of (+)-epibatidine oxalate attributable to nicotinic agonist activity. British Journal of Pharmacology. 113: 1487-93. PMID 7889306 |
0.342 |
|
| 1994 |
Elliott J, Smart D, Lambert DG, Traynor JR. Characterisation of mu-opioid receptors on SH-SY5Y cells using naloxonazine and beta-funaltrexamine. European Journal of Pharmacology. 268: 447-50. PMID 7805771 DOI: 10.1016/0922-4106(94)90072-8 |
0.623 |
|
| 1994 |
Traynor JR. Opioid receptors and their subtypes: focus on peripheral isolated tissue preparations. Neurochemistry International. 24: 427-32. PMID 7647697 DOI: 10.1016/0197-0186(94)90090-6 |
0.524 |
|
| 1994 |
Elliott J, Traynor JR. Lack of modulation of μ-opioid agonists by δ-opioid agonists in isolated tissue bioassay preparations Regulatory Peptides. 53: S41-S42. DOI: 10.1016/0167-0115(94)90231-3 |
0.561 |
|
| 1994 |
Schmidhammer H, Jennewein HK, Bell K, Patel D, Traynor JR. 3-Hydroxy analogues of the μ-selective opioid antagonist cyprodime Regulatory Peptides. 53: S37-S38. DOI: 10.1016/0167-0115(94)90229-1 |
0.557 |
|
| 1993 |
Traynor JR, Elliott J. delta-Opioid receptor subtypes and cross-talk with mu-receptors. Trends in Pharmacological Sciences. 14: 84-6. PMID 8387705 DOI: 10.1016/0165-6147(93)90068-U |
0.598 |
|
| 1993 |
Elliott J, Smart D, Traynor JR, Lambert DG. Characterization of the mu-opioid receptors on SH-SY5Y cells using beta-funaltrexamine (beta-FNA) and naloxonazine. Biochemical Society Transactions. 21: 469S. PMID 8132037 DOI: 10.1042/BST021469S |
0.41 |
|
| 1993 |
Dixon DM, Traynor JR. Conversion of dynorphin A(1-8) to [Leu5]-enkephalin in rat central nervous tissue during development. Neuropeptides. 25: 121-5. PMID 8105413 DOI: 10.1016/0143-4179(93)90091-N |
0.418 |
|
| 1993 |
Schmidhammer H, Schratz A, Schmidt C, Patel D, Traynor JR. Synthesis and biological evaluation of 14-alkoxymorphinans. Part 9. 14-O-ethyl-5-methylnaltrexone, an opioid antagonist with unusual selectivity Helvetica Chimica Acta. 76: 476-480. DOI: 10.1002/hlca.19930760131 |
0.446 |
|
| 1992 |
Rodriguez FD, Bardaji E, Traynor JR. Differential effects of Mg2+ and other divalent cations on the binding of tritiated opioid ligands. Journal of Neurochemistry. 59: 467-72. PMID 1321228 |
0.501 |
|
| 1992 |
Franklin TG, Traynor JR. Alkylation of the μ-opioid receptor by N-ethylmaleimide and phenoxybenzamine: Differentiation of μ-opioid ligands by protection experiments Molecular Neuropharmacology. 1: 187-193. |
0.59 |
|
| 1991 |
Franklin TG, Traynor JR. Alkylation with beta-funaltrexamine suggests differences between mu-opioid receptor systems in guinea-pig brain and myenteric-plexus. British Journal of Pharmacology. 102: 718-22. PMID 1364844 DOI: 10.1111/j.1476-5381.1991.tb12239.x |
0.332 |
|
| 1990 |
Traynor JR, Hunter JC, Rodriguez RE, Hill RG, Hughes J. Delta-opioid receptor binding sites in rodent spinal cord. British Journal of Pharmacology. 100: 319-23. PMID 2165837 DOI: 10.1111/j.1476-5381.1990.tb15802.x |
0.537 |
|
| 1990 |
Dixon DM, Traynor JR. Evidence that the agonist action of dynorphin A(1-8) in the guinea-pig myenteric-plexus may be mediated partly through conversion to [Leu5]enkephalin. British Journal of Pharmacology. 101: 674-8. PMID 1981690 |
0.535 |
|
| 1990 |
Rogers H, Hayes AG, Birch PJ, Traynor JR, Lawrence AJ. The selectivity of the opioid antagonist, naltrindole, for delta-opioid receptors. The Journal of Pharmacy and Pharmacology. 42: 358-9. PMID 1976787 DOI: 10.1111/j.2042-7158.1990.tb05428.x |
0.591 |
|
| 1990 |
Lawrence AJ, Traynor JR. Characterisation of opioid binding sites using selective antagonists. Progress in Clinical and Biological Research. 328: 121-4. PMID 1968257 |
0.482 |
|
| 1989 |
Wood MS, Traynor JR. [3H]diprenorphine binding to kappa-sites in guinea-pig and rat brain: evidence for apparent heterogeneity. Journal of Neurochemistry. 53: 173-8. PMID 2542456 DOI: 10.1111/j.1471-4159.1989.tb07310.x |
0.455 |
|
| 1989 |
Traynor J. Subtypes of the κ-opioid receptor: fact or fiction? Trends in Pharmacological Sciences. 10: 52-53. PMID 2541524 DOI: 10.1016/0165-6147(89)90074-6 |
0.694 |
|
| 1987 |
Traynor JR, Corbett AD, Kosterlitz HW. Diprenorphine has agonist activity at opioid kappa-receptors in the myenteric plexus of the guinea-pig ileum. European Journal of Pharmacology. 137: 85-9. PMID 3038579 DOI: 10.1016/0014-2999(87)90185-3 |
0.611 |
|
| 1987 |
Kosterlitz HW, Paterson SJ, Robson LE, Traynor JR. Effects of cations on binding, in membrane suspensions, of various opioids at mu-sites of rabbit cerebellum and kappa-sites of guinea-pig cerebellum. British Journal of Pharmacology. 91: 431-7. PMID 3038237 DOI: 10.1111/j.1476-5381.1987.tb10298.x |
0.364 |
|
| 1986 |
Gill JC, Lockey PM, Marples BA, Traynor JR. 3,17 beta-Dihydroxy-20,21-epoxy-19-norpregna-1,3,5(10)-trienes: synthesis, rearrangement, cytotoxicity, and estrogen-receptor binding. Journal of Medicinal Chemistry. 29: 1537-40. PMID 3735321 DOI: 10.1021/Jm00158A039 |
0.329 |
|
| 1986 |
Appelmans N, Carroll JA, Rance MJ, Simon EJ, Traynor JR. Sodium ions increase the binding of the antagonist peptide ICI 174864 to the delta-opiate receptor. Neuropeptides. 7: 139-43. PMID 3010168 DOI: 10.1016/0143-4179(86)90089-2 |
0.38 |
|
| 1985 |
Miller L, Rance MJ, Shaw JS, Traynor JR. Conversion of dynorphin-(1-9) to [Leu5]enkephalin by the mouse vas deferens in vitro. European Journal of Pharmacology. 116: 159-63. PMID 2865158 DOI: 10.1016/0014-2999(85)90197-9 |
0.599 |
|
| 1984 |
Traynor JR, Rance MJ. Opiate binding in the rat spinal cord: evidence for mu and delta sites. Neuropeptides. 5: 81-4. PMID 6099519 DOI: 10.1016/0143-4179(84)90032-5 |
0.305 |
|
| 1984 |
Traynor JR. Opioid binding sites in the spinal cord Trends in Pharmacological Sciences. 5: 495-496. DOI: 10.1016/0165-6147(84)90523-6 |
0.406 |
|
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