Susan L. Lindquist - Publications

Affiliations: 
Biology; Whitehead Institute Massachusetts Institute of Technology, Cambridge, MA, United States 
Area:
protein folding
Website:
http://lindquistlab.wi.mit.edu/about-susan-lindquist/

137 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Pedley AM, Karras GI, Zhang X, Lindquist SL, Benkovic SJ. The Role of HSP90 in the Regulation of de novo Purine Biosynthesis. Biochemistry. PMID 29553718 DOI: 10.1021/acs.biochem.8b00140  0.68
2015 Tsvetkov P, Mendillo ML, Zhao J, Carette JE, Merrill PH, Cikes D, Varadarajan M, van Diemen FR, Penninger JM, Goldberg AL, Brummelkamp TR, Santagata S, Lindquist S. Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome. Elife. 4. PMID 26327695 DOI: 10.7554/eLife.08467  1
2015 Bagley AF, Scherz-Shouval R, Galie PA, Zhang AQ, Wyckoff J, Whitesell L, Chen CS, Lindquist S, Bhatia SN. Endothelial thermotolerance impairs nanoparticle transport in tumors. Cancer Research. PMID 26122846 DOI: 10.1158/0008-5472.CAN-15-0325  1
2015 Herman JD, Pepper LR, Cortese JF, Estiu G, Galinsky K, Zuzarte-Luis V, Derbyshire ER, Ribacke U, Lukens AK, Santos SA, Patel V, Clish CB, Sullivan WJ, Zhou H, Bopp SE, ... ... Lindquist S, et al. The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs. Science Translational Medicine. 7: 288ra77. PMID 25995223 DOI: 10.1126/scitranslmed.aaa3575  1
2014 Whitesell L, Santagata S, Mendillo ML, Lin NU, Proia DA, Lindquist S. HSP90 empowers evolution of resistance to hormonal therapy in human breast cancer models. Proceedings of the National Academy of Sciences of the United States of America. 111: 18297-302. PMID 25489079 DOI: 10.1073/pnas.1421323111  1
2014 Reymer A, Frederick KK, Rocha S, Beke-Somfai T, Kitts CC, Lindquist S, Nordén B. Orientation of aromatic residues in amyloid cores: structural insights into prion fiber diversity. Proceedings of the National Academy of Sciences of the United States of America. 111: 17158-63. PMID 25404291 DOI: 10.1073/pnas.1415663111  1
2014 Narayan P, Ehsani S, Lindquist S. Combating neurodegenerative disease with chemical probes and model systems. Nature Chemical Biology. 10: 911-20. PMID 25325702 DOI: 10.1038/nchembio.1663  1
2014 Jarosz DF, Brown JC, Walker GA, Datta MS, Ung WL, Lancaster AK, Rotem A, Chang A, Newby GA, Weitz DA, Bisson LF, Lindquist S. Cross-kingdom chemical communication drives a heritable, mutually beneficial prion-based transformation of metabolism. Cell. 158: 1083-93. PMID 25171409 DOI: 10.1016/j.cell.2014.07.025  1
2014 Jarosz DF, Lancaster AK, Brown JC, Lindquist S. An evolutionarily conserved prion-like element converts wild fungi from metabolic specialists to generalists. Cell. 158: 1072-82. PMID 25171408 DOI: 10.1016/j.cell.2014.07.024  1
2014 Caraveo G, Auluck PK, Whitesell L, Chung CY, Baru V, Mosharov EV, Yan X, Ben-Johny M, Soste M, Picotti P, Kim H, Caldwell KA, Caldwell GA, Sulzer D, Yue DT, ... Lindquist S, et al. Calcineurin determines toxic versus beneficial responses to α-synuclein. Proceedings of the National Academy of Sciences of the United States of America. 111: E3544-52. PMID 25122673 DOI: 10.1073/pnas.1413201111  1
2013 Rohner N, Jarosz DF, Kowalko JE, Yoshizawa M, Jeffery WR, Borowsky RL, Lindquist S, Tabin CJ. Cryptic variation in morphological evolution: HSP90 as a capacitor for loss of eyes in cavefish. Science (New York, N.Y.). 342: 1372-5. PMID 24337296 DOI: 10.1126/science.1240276  1
2013 Vincent BM, Lancaster AK, Scherz-Shouval R, Whitesell L, Lindquist S. Fitness trade-offs restrict the evolution of resistance to amphotericin B. Plos Biology. 11: e1001692. PMID 24204207 DOI: 10.1371/journal.pbio.1001692  1
2013 Tardiff DF, Jui NT, Khurana V, Tambe MA, Thompson ML, Chung CY, Kamadurai HB, Kim HT, Lancaster AK, Caldwell KA, Caldwell GA, Rochet JC, Buchwald SL, Lindquist S. Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons. Science (New York, N.Y.). 342: 979-83. PMID 24158909 DOI: 10.1126/science.1245321  0.72
2013 Chung CY, Khurana V, Auluck PK, Tardiff DF, Mazzulli JR, Soldner F, Baru V, Lou Y, Freyzon Y, Cho S, Mungenast AE, Muffat J, Mitalipova M, Pluth MD, Jui NT, ... ... Lindquist S, et al. Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons. Science (New York, N.Y.). 342: 983-7. PMID 24158904 DOI: 10.1126/science.1245296  0.72
2013 Jackson WS, Borkowski AW, Watson NE, King OD, Faas H, Jasanoff A, Lindquist S. Profoundly different prion diseases in knock-in mice carrying single PrP codon substitutions associated with human diseases. Proceedings of the National Academy of Sciences of the United States of America. 110: 14759-64. PMID 23959875 DOI: 10.1073/pnas.1312006110  1
2013 Youngsaye W, Hartland CL, Morgan BJ, Ting A, Nag PP, Vincent B, Mosher CA, Bittker JA, Dandapani S, Palmer M, Whitesell L, Lindquist S, Schreiber SL, Munoz B. ML212: A small-molecule probe for investigating fluconazole resistance mechanisms in Candida albicans. Beilstein Journal of Organic Chemistry. 9: 1501-7. PMID 23946849 DOI: 10.3762/bjoc.9.171  1
2013 Santagata S, Mendillo ML, Tang YC, Subramanian A, Perley CC, Roche SP, Wong B, Narayan R, Kwon H, Koeva M, Amon A, Golub TR, Porco JA, Whitesell L, Lindquist S. Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state. Science (New York, N.Y.). 341: 1238303. PMID 23869022 DOI: 10.1126/science.1238303  1
2013 Taipale M, Krykbaeva I, Whitesell L, Santagata S, Zhang J, Liu Q, Gray NS, Lindquist S. Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells. Nature Biotechnology. 31: 630-7. PMID 23811600 DOI: 10.1038/nbt.2620  1
2013 Holmes DL, Lancaster AK, Lindquist S, Halfmann R. Heritable remodeling of yeast multicellularity by an environmentally responsive prion. Cell. 153: 153-65. PMID 23540696 DOI: 10.1016/j.cell.2013.02.026  1
2013 Newby GA, Lindquist S. Blessings in disguise: Biological benefits of prion-like mechanisms Trends in Cell Biology. 23: 251-259. PMID 23485338 DOI: 10.1016/j.tcb.2013.01.007  1
2013 Grossniklaus U, Kelly WG, Kelly B, Ferguson-Smith AC, Pembrey M, Lindquist S. Transgenerational epigenetic inheritance: how important is it? Nature Reviews. Genetics. 14: 228-35. PMID 23416892 DOI: 10.1038/nrg3435  1
2012 McLellan CA, Whitesell L, King OD, Lancaster AK, Mazitschek R, Lindquist S. Inhibiting GPI anchor biosynthesis in fungi stresses the endoplasmic reticulum and enhances immunogenicity. Acs Chemical Biology. 7: 1520-8. PMID 22724584 DOI: 10.1021/cb300235m  1
2012 Youngsaye W, Dockendorff C, Vincent B, Hartland CL, Bittker JA, Dandapani S, Palmer M, Whitesell L, Lindquist S, Schreiber SL, Munoz B. Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles. Bioorganic & Medicinal Chemistry Letters. 22: 3362-5. PMID 22497765 DOI: 10.1016/j.bmcl.2012.02.035  1
2012 Halfmann R, Jarosz DF, Jones SK, Chang A, Lancaster AK, Lindquist S. Prions are a common mechanism for phenotypic inheritance in wild yeasts. Nature. 482: 363-8. PMID 22337056 DOI: 10.1038/nature10875  1
2012 Donmez G, Arun A, Chung CY, McLean PJ, Lindquist S, Guarente L. SIRT1 protects against α-synuclein aggregation by activating molecular chaperones. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 124-32. PMID 22219275 DOI: 10.1523/JNEUROSCI.3442-11.2012  1
2012 Tardiff DF, Tucci ML, Caldwell KA, Caldwell GA, Lindquist S. Different 8-hydroxyquinolines protect models of TDP-43 protein, α-synuclein, and polyglutamine proteotoxicity through distinct mechanisms. The Journal of Biological Chemistry. 287: 4107-20. PMID 22147697 DOI: 10.1074/jbc.M111.308668  1
2012 Bryan AW, O'Donnell CW, Menke M, Cowen LJ, Lindquist S, Berger B. STITCHER: Dynamic assembly of likely amyloid and prion β-structures from secondary structure predictions. Proteins. 80: 410-20. PMID 22095906 DOI: 10.1002/prot.23203  1
2012 Santagata S, Xu YM, Wijeratne EM, Kontnik R, Rooney C, Perley CC, Kwon H, Clardy J, Kesari S, Whitesell L, Lindquist S, Gunatilaka AA. Using the heat-shock response to discover anticancer compounds that target protein homeostasis. Acs Chemical Biology. 7: 340-9. PMID 22050377 DOI: 10.1021/cb200353m  1
2011 Lindquist SL. QnAs with Susan L. Lindquist. Interviewed by Prashant Nair. Proceedings of the National Academy of Sciences of the United States of America. 108: 19861. PMID 22123945 DOI: 10.1073/pnas.1118394108  1
2011 Santagata S, Hu R, Lin NU, Mendillo ML, Collins LC, Hankinson SE, Schnitt SJ, Whitesell L, Tamimi RM, Lindquist S, Ince TA. High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer. Proceedings of the National Academy of Sciences of the United States of America. 108: 18378-83. PMID 22042860 DOI: 10.1073/pnas.1115031108  1
2011 Treusch S, Hamamichi S, Goodman JL, Matlack KE, Chung CY, Baru V, Shulman JM, Parrado A, Bevis BJ, Valastyan JS, Han H, Lindhagen-Persson M, Reiman EM, Evans DA, Bennett DA, ... ... Lindquist S, et al. Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast. Science (New York, N.Y.). 334: 1241-5. PMID 22033521 DOI: 10.1126/science.1213210  1
2011 Valastyan JS, Lindquist S. Torsina and the Torsina-Interacting protein printor have no impact on endoplasmic reticulum stress or protein trafficking in yeast Plos One. 6. PMID 21818381 DOI: 10.1371/journal.pone.0022744  1
2011 Youngsaye W, Vincent B, Hartland CL, Morgan BJ, Buhrlage SJ, Johnston S, Bittker JA, MacPherson L, Dandapani S, Palmer M, Whitesell L, Lindquist S, Schreiber SL, Munoz B. Piperazinyl quinolines as chemosensitizers to increase fluconazole susceptibility of Candida albicans clinical isolates. Bioorganic & Medicinal Chemistry Letters. 21: 5502-5. PMID 21802942 DOI: 10.1016/j.bmcl.2011.06.105  1
2011 Castro CE, Dong J, Boyce MC, Lindquist S, Lang MJ. Physical properties of polymorphic yeast prion amyloid fibers Biophysical Journal. 101: 439-448. PMID 21767497 DOI: 10.1016/j.bpj.2011.06.016  1
2011 Soldner F, Laganière J, Cheng AW, Hockemeyer D, Gao Q, Alagappan R, Khurana V, Golbe LI, Myers RH, Lindquist S, Zhang L, Guschin D, Fong LK, Vu BJ, Meng X, et al. Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations. Cell. 146: 318-31. PMID 21757228 DOI: 10.1016/j.cell.2011.06.019  1
2011 Halfmann R, Alberti S, Krishnan R, Lyle N, O'Donnell CW, King OD, Berger B, Pappu RV, Lindquist S. Opposing effects of glutamine and asparagine govern prion formation by intrinsically disordered proteins. Molecular Cell. 43: 72-84. PMID 21726811 DOI: 10.1016/j.molcel.2011.05.013  1
2011 O'Donnell CW, Waldispühl J, Lis M, Halfmann R, Devadas S, Lindquist S, Berger B. A method for probing the mutational landscape of amyloid structure Bioinformatics. 27: i34-i42. PMID 21685090 DOI: 10.1093/bioinformatics/btr238  1
2011 Manogaran AL, Hong JY, Hufana J, Tyedmers J, Lindquist S, Liebman SW. Prion formation and polyglutamine aggregation are controlled by two classes of genes Plos Genetics. 7. PMID 21625618 DOI: 10.1371/journal.pgen.1001386  1
2011 Lindquist S. A flurry of folding problems: an interview with Susan Lindquist by Jane Gitschier Plos Genetics. 7: e1002076. PMID 21589898 DOI: 10.1371/journal.pgen.1002076  1
2011 Lan A, Smoly IY, Rapaport G, Lindquist S, Fraenkel E, Yeger-Lotem E. ResponseNet: Revealing signaling and regulatory networks linking genetic and transcriptomic screening data Nucleic Acids Research. 39: W424-W429. PMID 21576238 DOI: 10.1093/nar/gkr359  1
2011 Ju S, Tardiff DF, Han H, Divya K, Zhong Q, Maquat LE, Bosco DA, Hayward LJ, Brown RH, Lindquist S, Ringe D, Petsko GA. A yeast model of FUS/TLS-dependent cytotoxicity. Plos Biology. 9: e1001052. PMID 21541368 DOI: 10.1371/journal.pbio.1001052  1
2011 Resenberger UK, Harmeier A, Woerner AC, Goodman JL, Müller V, Krishnan R, Vabulas RM, Kretzschmar HA, Lindquist S, Hartl FU, Multhaup G, Winklhofer KF, Tatzelt J. The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication. The Embo Journal. 30: 2057-70. PMID 21441896 DOI: 10.1038/emboj.2011.86  1
2011 Heinrich SU, Lindquist S. Protein-only mechanism induces self-perpetuating changes in the activity of neuronal Aplysia cytoplasmic polyadenylation element binding protein (CPEB). Proceedings of the National Academy of Sciences of the United States of America. 108: 2999-3004. PMID 21270333 DOI: 10.1073/pnas.1019368108  1
2011 Dumitriu A, Pacheco CD, Wilk JB, Strathearn KE, Latourelle JC, Goldwurm S, Pezzoli G, Rochet JC, Lindquist S, Myers RH. Cyclin-G-associated kinase modifies α-synuclein expression levels and toxicity in Parkinson's disease: results from the GenePD Study. Human Molecular Genetics. 20: 1478-87. PMID 21258085 DOI: 10.1093/hmg/ddr026  1
2010 Jarosz DF, Lindquist S. Hsp90 and environmental stress transform the adaptive value of natural genetic variation. Science (New York, N.Y.). 330: 1820-4. PMID 21205668 DOI: 10.1126/science.1195487  1
2010 Dong J, Castro CE, Boyce MC, Lang MJ, Lindquist S. Optical trapping with high forces reveals unexpected behaviors of prion fibrils Nature Structural and Molecular Biology. 17: 1422-1430. PMID 21113168 DOI: 10.1038/nsmb.1954  1
2010 Lindquist S. Three quite different things that matter to me Molecular Biology of the Cell. 21: 3804. PMID 21079020  1
2010 Jarosz DF, Taipale M, Lindquist S. Protein homeostasis and the phenotypic manifestation of genetic diversity: principles and mechanisms. Annual Review of Genetics. 44: 189-216. PMID 21047258 DOI: 10.1146/annurev.genet.40.110405.090412  1
2010 Halfmann R, Lindquist S. Epigenetics in the extreme: Prions and the inheritance of environmentally acquired traits Science. 330: 629-632. PMID 21030648 DOI: 10.1126/science.1191081  1
2010 Alberti S, Halfmann R, Lindquist S. Biochemical, cell biological, and genetic assays to analyze amyloid and prion aggregation in yeast. Methods in Enzymology. 470: 709-34. PMID 20946833 DOI: 10.1016/S0076-6879(10)70030-6  1
2010 Lewandowski NM, Ju S, Verbitsky M, Ross B, Geddie ML, Rockenstein E, Adame A, Muhammad A, Vonsattel JP, Ringe D, Cote L, Lindquist S, Masliah E, Petsko GA, Marder K, et al. Polyamine pathway contributes to the pathogenesis of Parkinson disease. Proceedings of the National Academy of Sciences of the United States of America. 107: 16970-5. PMID 20837543 DOI: 10.1073/pnas.1011751107  1
2010 Taipale M, Jarosz DF, Lindquist S. HSP90 at the hub of protein homeostasis: emerging mechanistic insights. Nature Reviews. Molecular Cell Biology. 11: 515-28. PMID 20531426 DOI: 10.1038/nrm2918  1
2010 Auluck PK, Caraveo G, Lindquist S. α-Synuclein: membrane interactions and toxicity in Parkinson's disease. Annual Review of Cell and Developmental Biology. 26: 211-33. PMID 20500090 DOI: 10.1146/annurev.cellbio.042308.113313  1
2010 Garrity SJ, Sivanathan V, Dong J, Lindquist S, Hochschild A. Conversion of a yeast prion protein to an infectious form in bacteria. Proceedings of the National Academy of Sciences of the United States of America. 107: 10596-601. PMID 20484678 DOI: 10.1073/pnas.0913280107  1
2010 Khurana V, Lindquist S. Modelling neurodegeneration in Saccharomyces cerevisiae: why cook with baker's yeast? Nature Reviews. Neuroscience. 11: 436-49. PMID 20424620 DOI: 10.1038/nrn2809  1
2010 Tyedmers J, Treusch S, Dong J, McCaffery JM, Bevis B, Lindquist S. Prion induction involves an ancient system for the sequestration of aggregated proteins and heritable changes in prion fragmentation. Proceedings of the National Academy of Sciences of the United States of America. 107: 8633-8. PMID 20421488 DOI: 10.1073/pnas.1003895107  1
2010 Halfmann R, Alberti S, Lindquist S. Prions, protein homeostasis, and phenotypic diversity. Trends in Cell Biology. 20: 125-33. PMID 20071174 DOI: 10.1016/j.tcb.2009.12.003  1
2010 Su LJ, Auluck PK, Outeiro TF, Yeger-Lotem E, Kritzer JA, Tardiff DF, Strathearn KE, Liu F, Cao S, Hamamichi S, Hill KJ, Caldwell KA, Bell GW, Fraenkel E, Cooper AA, ... ... Lindquist S, et al. Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models. Disease Models & Mechanisms. 3: 194-208. PMID 20038714 DOI: 10.1242/dmm.004267  1
2010 Faas H, Jackson WS, Borkowski AW, Wang X, Ma J, Lindquist S, Jasanoff A. Context-dependent perturbation of neural systems in transgenic mice expressing a cytosolic prion protein. Neuroimage. 49: 2607-17. PMID 19835963 DOI: 10.1016/j.neuroimage.2009.10.009  1
2010 Tessier PM, Lindquist S. Unraveling Molecular Mechanisms and Structures of Self-Perpetuating Prions Protein Misfolding Diseases: Current and Emerging Principles and Therapies. 145-174. DOI: 10.1002/9780470572702.ch8  1
2009 Lindquist S. Protein folding sculpting evolutionary change Cold Spring Harbor Symposia On Quantitative Biology. 74: 103-108. PMID 20375316 DOI: 10.1101/sqb.2009.74.043  1
2009 Steele AD, Zhou Z, Jackson WS, Zhu C, Auluck P, Moskowitz MA, Chesselet MF, Lindquist S. Context dependent neuroprotective properties of prion protein (PrP). Prion. 3: 240-9. PMID 19901559  1
2009 Brown JC, Lindquist S. A heritable switch in carbon source utilization driven by an unusual yeast prion. Genes & Development. 23: 2320-32. PMID 19797769 DOI: 10.1101/gad.1839109  1
2009 Sénéchal P, Arseneault G, Leroux A, Lindquist S, Rokeach LA. The Schizosaccharomyces pombe Hsp104 disaggregase is unable to propagate the [PSI] prion. Plos One. 4: e6939. PMID 19759825 DOI: 10.1371/journal.pone.0006939  1
2009 Jackson WS, Borkowski AW, Faas H, Steele AD, King OD, Watson N, Jasanoff A, Lindquist S. Spontaneous generation of prion infectivity in fatal familial insomnia knockin mice. Neuron. 63: 438-50. PMID 19709627 DOI: 10.1016/j.neuron.2009.07.026  1
2009 Wacker JL, Huang SY, Steele AD, Aron R, Lotz GP, Nguyen Q, Giorgini F, Roberson ED, Lindquist S, Masliah E, Muchowski PJ. Loss of Hsp70 exacerbates pathogenesis but not levels of fibrillar aggregates in a mouse model of Huntington's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 9104-14. PMID 19605647 DOI: 10.1523/JNEUROSCI.2250-09.2009  1
2009 Kritzer JA, Hamamichi S, McCaffery JM, Santagata S, Naumann TA, Caldwell KA, Caldwell GA, Lindquist S. Rapid selection of cyclic peptides that reduce alpha-synuclein toxicity in yeast and animal models. Nature Chemical Biology. 5: 655-63. PMID 19597508 DOI: 10.1038/nchembio.193  1
2009 Tessier PM, Lindquist S. Unraveling infectious structures, strain variants and species barriers for the yeast prion [PSI+]. Nature Structural & Molecular Biology. 16: 598-605. PMID 19491937 DOI: 10.1038/nsmb.1617  1
2009 Treusch S, Cyr DM, Lindquist S. Amyloid deposits: protection against toxic protein species? Cell Cycle (Georgetown, Tex.). 8: 1668-74. PMID 19411847  1
2009 Wendler P, Shorter J, Snead D, Plisson C, Clare DK, Lindquist S, Saibil HR. Motor Mechanism for Protein Threading through Hsp104 Molecular Cell. 34: 81-92. PMID 19362537 DOI: 10.1016/j.molcel.2009.02.026  1
2009 Beauregard PB, Guérin R, Turcotte C, Lindquist S, Rokeach LA. A nucleolar protein allows viability in the absence of the essential ER-residing molecular chaperone calnexin Journal of Cell Science. 122: 1342-1351. PMID 19351719 DOI: 10.1242/jcs.040949  1
2009 Alberti S, Halfmann R, King O, Kapila A, Lindquist S. A systematic survey identifies prions and illuminates sequence features of prionogenic proteins. Cell. 137: 146-58. PMID 19345193 DOI: 10.1016/j.cell.2009.02.044  1
2009 Whitesell L, Lindquist S. Inhibiting the transcription factor HSF1 as an anticancer strategy Expert Opinion On Therapeutic Targets. 13: 469-478. PMID 19335068 DOI: 10.1517/14728220902832697  1
2009 Bryan AW, Menke M, Cowen LJ, Lindquist SL, Berger B. BETASCAN: probable beta-amyloids identified by pairwise probabilistic analysis. Plos Computational Biology. 5: e1000333. PMID 19325876 DOI: 10.1371/journal.pcbi.1000333  1
2009 Yeger-Lotem E, Riva L, Su LJ, Gitler AD, Cashikar AG, King OD, Auluck PK, Geddie ML, Valastyan JS, Karger DR, Lindquist S, Fraenkel E. Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity. Nature Genetics. 41: 316-23. PMID 19234470 DOI: 10.1038/ng.337  1
2009 Cowen LE, Singh SD, Köhler JR, Collins C, Zaas AK, Schell WA, Aziz H, Mylonakis E, Perfect JR, Whitesell L, Lindquist S. Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease Proceedings of the National Academy of Sciences of the United States of America. 106: 2818-2823. PMID 19196973 DOI: 10.1073/pnas.0813394106  1
2009 Gitler AD, Chesi A, Geddie ML, Strathearn KE, Hamamichi S, Hill KJ, Caldwell KA, Caldwell GA, Cooper AA, Rochet JC, Lindquist S. Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity. Nature Genetics. 41: 308-15. PMID 19182805 DOI: 10.1038/ng.300  1
2009 Rappley I, Gitler AD, Selvy PE, LaVoie MJ, Levy BD, Brown HA, Lindquist S, Selkoe DJ. Evidence that alpha-synuclein does not inhibit phospholipase D. Biochemistry. 48: 1077-83. PMID 19146388 DOI: 10.1021/bi801871h  1
2008 Heikenwalder M, Kurrer MO, Margalith I, Kranich J, Zeller N, Haybaeck J, Polymenidou M, Matter M, Bremer J, Jackson WS, Lindquist S, Sigurdson CJ, Aguzzi A. Lymphotoxin-dependent prion replication in inflammatory stromal cells of granulomas. Immunity. 29: 998-1008. PMID 19100703 DOI: 10.1016/j.immuni.2008.10.014  1
2008 Tyedmers J, Madariaga ML, Lindquist S. Prion switching in response to environmental stress Plos Biology. 6: 2605-2613. PMID 19067491 DOI: 10.1371/journal.pbio.0060294  1
2008 Lindquist S. Using yeast to understand protein folding diseases: An interview with Susan Lindquist Dmm Disease Models and Mechanisms. 1: 17-19. PMID 19048046 DOI: 10.1242/dmm.000810  1
2008 Duennwald ML, Lindquist S. Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity. Genes & Development. 22: 3308-19. PMID 19015277 DOI: 10.1101/gad.1673408  1
2008 Shorter J, Lindquist S. Hsp104, Hsp70 and Hsp40 interplay regulates formation, growth and elimination of Sup35 prions Embo Journal. 27: 2712-2724. PMID 18833196 DOI: 10.1038/emboj.2008.194  1
2008 Chen D, Steele AD, Hutter G, Bruno J, Govindarajan A, Easlon E, Lin SJ, Aguzzi A, Lindquist S, Guarente L. The role of calorie restriction and SIRT1 in prion-mediated neurodegeneration. Experimental Gerontology. 43: 1086-93. PMID 18799131 DOI: 10.1016/j.exger.2008.08.050  1
2008 Steele AD, Hutter G, Jackson WS, Heppner FL, Borkowski AW, King OD, Raymond GJ, Aguzzi A, Lindquist S. Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease. Proceedings of the National Academy of Sciences of the United States of America. 105: 13626-31. PMID 18757733 DOI: 10.1073/pnas.0806319105  1
2008 Lo Bianco C, Shorter J, Régulier E, Lashuel H, Iwatsubo T, Lindquist S, Aebischer P. Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease. The Journal of Clinical Investigation. 118: 3087-97. PMID 18704197 DOI: 10.1172/JCI35781  1
2008 Wang H, Duennwald ML, Roberts BE, Rozeboom LM, Zhang YL, Steele AD, Krishnan R, Su LJ, Griffin D, Mukhopadhyay S, Hennessy EJ, Weigele P, Blanchard BJ, King J, Deniz AA, ... ... Lindquist S, et al. Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs. Proceedings of the National Academy of Sciences of the United States of America. 105: 7159-64. PMID 18480256 DOI: 10.1073/pnas.0801934105  0.92
2008 Douglas PM, Treusch S, Ren HY, Halfmann R, Duennwald ML, Lindquist S, Cyr DM. Chaperone-dependent amyloid assembly protects cells from prion toxicity. Proceedings of the National Academy of Sciences of the United States of America. 105: 7206-11. PMID 18480252 DOI: 10.1073/pnas.0802593105  1
2008 Johnson BS, McCaffery JM, Lindquist S, Gitler AD. A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicity. Proceedings of the National Academy of Sciences of the United States of America. 105: 6439-44. PMID 18434538 DOI: 10.1073/pnas.0802082105  1
2008 Fleming J, Outeiro TF, Slack M, Lindquist SL, Bulawa CE. Detection of compounds that rescue Rab1-synuclein toxicity. Methods in Enzymology. 439: 339-51. PMID 18374176 DOI: 10.1016/S0076-6879(07)00425-9  1
2008 Sadlish H, Rampelt H, Shorter J, Wegrzyn RD, Andréasson C, Lindquist S, Bukau B. Hsp110 chaperones regulate prion formation and propagation in S. cerevisiae by two discrete activities. Plos One. 3: e1763. PMID 18335038 DOI: 10.1371/journal.pone.0001763  1
2008 Sangster TA, Salathia N, Undurraga S, Milo R, Schellenberg K, Lindquist S, Queitsch C. HSP90 affects the expression of genetic variation and developmental stability in quantitative traits. Proceedings of the National Academy of Sciences of the United States of America. 105: 2963-8. PMID 18287065 DOI: 10.1073/pnas.0712200105  1
2008 Sangster TA, Salathia N, Lee HN, Watanabe E, Schellenberg K, Morneau K, Wang H, Undurraga S, Queitsch C, Lindquist S. HSP90-buffered genetic variation is common in Arabidopsis thaliana. Proceedings of the National Academy of Sciences of the United States of America. 105: 2969-74. PMID 18287064 DOI: 10.1073/pnas.0712210105  1
2008 Gitler AD, Bevis BJ, Shorter J, Strathearn KE, Hamamichi S, Su LJ, Caldwell KA, Caldwell GA, Rochet JC, McCaffery JM, Barlowe C, Lindquist S. The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis. Proceedings of the National Academy of Sciences of the United States of America. 105: 145-50. PMID 18162536 DOI: 10.1073/pnas.0710685105  1
2008 Halfmann R, Lindquist S. Screening for amyloid aggregation by semi-denaturing detergent-agarose gel electrophoresis Journal of Visualized Experiments. DOI: 10.3791/838  1
2008 Allendoerfer KL, Julie Su L, Lindquist S. Yeast Cells as a Discovery Platform for Parkinson's Disease and other Protein Misfolding Diseases Parkinson's Disease. 505-536. DOI: 10.1016/B978-0-12-374028-1.00038-5  1
2007 Wendler P, Shorter J, Plisson C, Cashikar AG, Lindquist S, Saibil HR. Atypical AAA+ Subunit Packing Creates an Expanded Cavity for Disaggregation by the Protein-Remodeling Factor Hsp104 Cell. 131: 1366-1377. PMID 18160044 DOI: 10.1016/j.cell.2007.10.047  1
2007 Hess S, Lindquist SL, Scheibel T. Alternative assembly pathways of the amyloidogenic yeast prion determinant Sup35-NM. Embo Reports. 8: 1196-201. PMID 17975557 DOI: 10.1038/sj.embor.7401096  1
2005 Homann OR, Cai H, Becker JM, Lindquist SL. Harnessing natural diversity to probe metabolic pathways. Plos Genetics. 1: e80. PMID 16429164 DOI: 10.1371/journal.pgen.0010080  1
2005 Whitesell L, Lindquist SL. HSP90 and the chaperoning of cancer. Nature Reviews. Cancer. 5: 761-72. PMID 16175177 DOI: 10.1038/nrc1716  1
2005 Krishnan R, Lindquist SL. Structural insights into a yeast prion illuminate nucleation and strain diversity. Nature. 435: 765-72. PMID 15944694 DOI: 10.1038/nature03679  1
2005 Cashikar AG, Duennwald M, Lindquist SL. A chaperone pathway in protein disaggregation. Hsp26 alters the nature of protein aggregates to facilitate reactivation by Hsp104. The Journal of Biological Chemistry. 280: 23869-75. PMID 15845535 DOI: 10.1074/jbc.M502854200  1
2004 Derkatch IL, Uptain SM, Outeiro TF, Krishnan R, Lindquist SL, Liebman SW. Effects of Q/N-rich, polyQ, and non-polyQ amyloids on the de novo formation of the [PSI+] prion in yeast and aggregation of Sup35 in vitro. Proceedings of the National Academy of Sciences of the United States of America. 101: 12934-9. PMID 15326312 DOI: 10.1073/pnas.0404968101  1
2004 True HL, Berlin I, Lindquist SL. Epigenetic regulation of translation reveals hidden genetic variation to produce complex traits. Nature. 431: 184-7. PMID 15311209 DOI: 10.1038/nature02885  1
2004 Rochet JC, Outeiro TF, Conway KA, Ding TT, Volles MJ, Lashuel HA, Bieganski RM, Lindquist SL, Lansbury PT. Interactions among alpha-synuclein, dopamine, and biomembranes: some clues for understanding neurodegeneration in Parkinson's disease. Journal of Molecular Neuroscience : Mn. 23: 23-34. PMID 15126689  1
2004 Scheibel T, Bloom J, Lindquist SL. The elongation of yeast prion fibers involves separable steps of association and conversion. Proceedings of the National Academy of Sciences of the United States of America. 101: 2287-92. PMID 14983002 DOI: 10.1073/pnas.0308754101  1
2003 Willingham S, Outeiro TF, DeVit MJ, Lindquist SL, Muchowski PJ. Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein. Science (New York, N.Y.). 302: 1769-72. PMID 14657499 DOI: 10.1126/science.1090389  1
2003 Scheibel T, Parthasarathy R, Sawicki G, Lin XM, Jaeger H, Lindquist SL. Conducting nanowires built by controlled self-assembly of amyloid fibers and selective metal deposition. Proceedings of the National Academy of Sciences of the United States of America. 100: 4527-32. PMID 12672964 DOI: 10.1073/pnas.0431081100  1
2002 Lindquist SL. Prion proteins: one surprise after another. Harvey Lectures. 98: 173-205. PMID 16033161  1
2002 Lindquist SL, Henikoff S. Self-perpetuating structural states in biology, disease, and genetics. Proceedings of the National Academy of Sciences of the United States of America. 99: 16377. PMID 12475994 DOI: 10.1073/pnas.212504699  1
2002 Liu JJ, Sondheimer N, Lindquist SL. Changes in the middle region of Sup35 profoundly alter the nature of epigenetic inheritance for the yeast prion [PSI+]. Proceedings of the National Academy of Sciences of the United States of America. 99: 16446-53. PMID 12461168 DOI: 10.1073/pnas.252652099  1
2002 Chernoff YO, Uptain SM, Lindquist SL. Analysis of prion factors in yeast. Methods in Enzymology. 351: 499-538. PMID 12073366 DOI: 10.1016/S0076-6879(02)51867-X  1
2002 Cashikar AG, Schirmer EC, Hattendorf DA, Glover JR, Ramakrishnan MS, Ware DM, Lindquist SL. Defining a pathway of communication from the C-terminal peptide binding domain to the N-terminal ATPase domain in a AAA protein. Molecular Cell. 9: 751-60. PMID 11983167 DOI: 10.1016/S1097-2765(02)00499-9  1
2002 Hattendorf DA, Lindquist SL. Analysis of the AAA sensor-2 motif in the C-terminal ATPase domain of Hsp104 with a site-specific fluorescent probe of nucleotide binding. Proceedings of the National Academy of Sciences of the United States of America. 99: 2732-7. PMID 11867765 DOI: 10.1073/pnas.261693199  1
2002 Hattendorf DA, Lindquist SL. Cooperative kinetics of both Hsp104 ATPase domains and interdomain communication revealed by AAA sensor-1 mutants. The Embo Journal. 21: 12-21. PMID 11782421 DOI: 10.1093/emboj/21.1.12  1
2001 Serio TR, Lindquist SL. The yeast prion [PSI+]: molecular insights and functional consequences. Advances in Protein Chemistry. 59: 391-412. PMID 11868278 DOI: 10.1016/S0065-3233(01)59012-9  1
2001 Scheibel T, Lindquist SL. The role of conformational flexibility in prion propagation and maintenance for Sup35p. Nature Structural Biology. 8: 958-62. PMID 11685242 DOI: 10.1038/nsb1101-958  1
2001 Serio TR, Cashikar AG, Kowal AS, Sawicki GJ, Lindquist SL. Self-perpetuating changes in Sup35 protein conformation as a mechanism of heredity in yeast. Biochemical Society Symposium. 35-43. PMID 11573346  1
2001 Serio TR, Lindquist SL. [PSI+], SUP35, and chaperones. Advances in Protein Chemistry. 57: 335-66. PMID 11447696 DOI: 10.1016/S0065-3233(01)57027-8  1
2001 Scheibel T, Kowal AS, Bloom JD, Lindquist SL. Bidirectional amyloid fiber growth for a yeast prion determinant. Current Biology : Cb. 11: 366-9. PMID 11267875 DOI: 10.1016/S0960-9822(01)00099-9  1
2001 Schirmer EC, Ware DM, Queitsch C, Kowal AS, Lindquist SL. Subunit interactions influence the biochemical and biological properties of Hsp104. Proceedings of the National Academy of Sciences of the United States of America. 98: 914-9. PMID 11158570 DOI: 10.1073/pnas.031568098  1
2000 True HL, Lindquist SL. A yeast prion provides a mechanism for genetic variation and phenotypic diversity. Nature. 407: 477-83. PMID 11028992 DOI: 10.1038/35035005  1
2000 Serio TR, Cashikar AG, Kowal AS, Sawicki GJ, Moslehi JJ, Serpell L, Arnsdorf MF, Lindquist SL. Nucleated conformational conversion and the replication of conformational information by a prion determinant. Science (New York, N.Y.). 289: 1317-21. PMID 10958771 DOI: 10.1126/science.289.5483.1317  1
2000 Serio TR, Lindquist SL. Protein-only inheritance in yeast: something to get [PSI+]-ched about. Trends in Cell Biology. 10: 98-105. PMID 10675903 DOI: 10.1016/S0962-8924(99)01711-0  1
1999 Serio TR, Lindquist SL. [PSI+]: an epigenetic modulator of translation termination efficiency. Annual Review of Cell and Developmental Biology. 15: 661-703. PMID 10611975 DOI: 10.1146/annurev.cellbio.15.1.661  1
1999 Serio TR, Cashikar AG, Moslehi JJ, Kowal AS, Lindquist SL. Yeast prion [psi +] and its determinant, Sup35p. Methods in Enzymology. 309: 649-73. PMID 10507053 DOI: 10.1016/S0076-6879(99)09043-6  1
1999 Newnam GP, Wegrzyn RD, Lindquist SL, Chernoff YO. Antagonistic interactions between yeast chaperones Hsp104 and Hsp70 in prion curing. Molecular and Cellular Biology. 19: 1325-33. PMID 9891066  1
1997 Golic MM, Rong YS, Petersen RB, Lindquist SL, Golic KG. FLP-mediated DNA mobilization to specific target sites in Drosophila chromosomes. Nucleic Acids Research. 25: 3665-71. PMID 9278488 DOI: 10.1093/nar/25.18.3665  1
1996 Tuite MF, Lindquist SL. Maintenance and inheritance of yeast prions. Trends in Genetics : Tig. 12: 467-71. PMID 8973157 DOI: 10.1016/0168-9525(96)10045-7  1
1996 Feder ME, Cartaño NV, Milos L, Krebs RA, Lindquist SL. Effect of engineering Hsp70 copy number on Hsp70 expression and tolerance of ecologically relevant heat shock in larvae and pupae of Drosophila melanogaster. The Journal of Experimental Biology. 199: 1837-44. PMID 8708583  1
1995 Chernoff YO, Lindquist SL, Ono B, Inge-Vechtomov SG, Liebman SW. Role of the chaperone protein Hsp104 in propagation of the yeast prion-like factor [psi+]. Science (New York, N.Y.). 268: 880-4. PMID 7754373  1
1995 Chernoff YO, Liebman SW, Patino M, Lindquist SL. Response from Chernoff et al. Trends in Microbiology. 3: 369. DOI: 10.1016/S0966-842X(00)88979-9  1
1993 Welte MA, Tetrault JM, Dellavalle RP, Lindquist SL. A new method for manipulating transgenes: engineering heat tolerance in a complex, multicellular organism. Current Biology : Cb. 3: 842-53. PMID 15335817 DOI: 10.1016/0960-9822(93)90218-D  1
1990 Sanchez Y, Lindquist SL. HSP104 required for induced thermotolerance. Science (New York, N.Y.). 248: 1112-5. PMID 2188365  1
1989 Susek RE, Lindquist SL. hsp26 of Saccharomyces cerevisiae is related to the superfamily of small heat shock proteins but is without a demonstrable function. Molecular and Cellular Biology. 9: 5265-71. PMID 2689876  1
1987 Gordon ED, Mora R, Meredith SC, Lindquist SL. Hypusine formation in eukaryotic initiation factor 4D is not reversed when rates or specificity of protein synthesis is altered. The Journal of Biological Chemistry. 262: 16590-5. PMID 3119589  1
1987 Gordon ED, Mora R, Meredith SC, Lee C, Lindquist SL. Eukaryotic initiation factor 4D, the hypusine-containing protein, is conserved among eukaryotes. The Journal of Biological Chemistry. 262: 16585-9. PMID 3119588  1
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