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Matthew J. LaMarche, Ph.D. - Publications

Affiliations: 
2002 University of Pennsylvania, Philadelphia, PA, United States 
Area:
Natural product synthesis
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17 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 LaMarche MJ, Acker MG, Argintaru A, Bauer D, Boisclair J, Chan H, Chen C, Chen YP, Chen Z, Deng Z, Doré M, Dunstan D, Fan J, Fekkes P, Firestone B, et al. Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer. Journal of Medicinal Chemistry. PMID 32910655 DOI: 10.1021/Acs.Jmedchem.0C01170  0.333
2016 LaMarche MJ, Leeds JA, Brewer J, Dean K, Ding J, Dzink-Fox J, Gamber G, Jain A, Kerrigan R, Krastel P, Lee K, Lombardo F, McKenney D, Neckermann G, Osborne CS, et al. Antibacterial and Solubility Optimization of Thiomuracin A. Journal of Medicinal Chemistry. PMID 27355833 DOI: 10.1021/acs.jmedchem.6b00726  0.362
2013 LaMarche MJ, Leeds JA, Dzink-Fox J, Gangl E, Krastel P, Neckermann G, Palestrant D, Patane MA, Rann EM, Tiamfook S, Yu D. Correction to Antibiotic Optimization and Chemical Structure Stabilization of Thiomuracin A Journal of Medicinal Chemistry. 56: 1360-1360. DOI: 10.1021/Jm4000402  0.339
2012 LaMarche MJ, Leeds JA, Dzink-Fox J, Gangl E, Krastel P, Neckermann G, Palestrant D, Patane MA, Rann EM, Tiamfook S, Yu D. Antibiotic optimization and chemical structure stabilization of thiomuracin A. Journal of Medicinal Chemistry. 55: 6934-41. PMID 22812377 DOI: 10.1021/jm300783c  0.424
2012 Trzasko A, Leeds JA, Praestgaard J, Lamarche MJ, McKenney D. Efficacy of LFF571 in a hamster model of Clostridium difficile infection. Antimicrobial Agents and Chemotherapy. 56: 4459-62. PMID 22644020 DOI: 10.1128/Aac.06355-11  0.315
2012 LaMarche MJ, Leeds JA, Amaral A, Brewer JT, Bushell SM, Deng G, Dewhurst JM, Ding J, Dzink-Fox J, Gamber G, Jain A, Lee K, Lee L, Lister T, McKenney D, et al. Discovery of LFF571: an investigational agent for Clostridium difficile infection. Journal of Medicinal Chemistry. 55: 2376-87. PMID 22315981 DOI: 10.1021/Jm201685H  0.305
2011 LaMarche MJ, Leeds JA, Amaral K, Brewer JT, Bushell SM, Dewhurst JM, Dzink-Fox J, Gangl E, Goldovitz J, Jain A, Mullin S, Neckermann G, Osborne C, Palestrant D, Patane MA, et al. Antibacterial optimization of 4-aminothiazolyl analogues of the natural product GE2270 A: identification of the cycloalkylcarboxylic acids. Journal of Medicinal Chemistry. 54: 8099-109. PMID 21999529 DOI: 10.1021/Jm200938F  0.302
2011 Leeds JA, LaMarche MJ, Brewer JT, Bushell SM, Deng G, Dewhurst JM, Dzink-Fox J, Gangl E, Jain A, Lee L, Lilly M, Manni K, Mullin S, Neckermann G, Osborne C, et al. In vitro and in vivo activities of novel, semisynthetic thiopeptide inhibitors of bacterial elongation factor Tu. Antimicrobial Agents and Chemotherapy. 55: 5277-83. PMID 21825297 DOI: 10.1128/Aac.00582-11  0.345
2011 LaMarche MJ, Leeds JA, Dzink-Fox J, Mullin S, Patane MA, Rann EM, Tiamfook S. 4-Aminothiazolyl analogs of GE2270 A: design, synthesis and evaluation of imidazole analogs. Bioorganic & Medicinal Chemistry Letters. 21: 3210-5. PMID 21550238 DOI: 10.1016/j.bmcl.2011.04.048  0.379
2011 LaMarche MJ, Leeds JA, Dzink-Fox J, Gunderson K, Krastel P, Memmert K, Patane MA, Rann EM, Schmitt E, Tiamfook S, Wang B. 4-Aminothiazolyl analogues of GE2270 A: antibacterial lead finding. Journal of Medicinal Chemistry. 54: 2517-21. PMID 21405087 DOI: 10.1021/jm101602q  0.422
2005 Smith AB, Freeze BS, LaMarche MJ, Sager J, Kinzler KW, Vogelstein B. Discodermolide analogues as the chemical component of combination bacteriolytic therapy. Bioorganic & Medicinal Chemistry Letters. 15: 3623-6. PMID 15979874 DOI: 10.1016/J.Bmcl.2005.05.068  0.578
2005 Smith AB, Freeze BS, Lamarche MJ, Hirose T, Brouard I, Xian M, Sundermann KF, Shaw SJ, Burlingame MA, Horwitz SB, Myles DC. Design, synthesis, and evaluation of analogues of (+)-14-normethyldiscodermolide. Organic Letters. 7: 315-8. PMID 15646986 DOI: 10.1021/Ol0476873  0.615
2005 Smith AB, Freeze BS, Lamarche MJ, Hirose T, Brouard I, Rucker PV, Xian M, Sundermann KF, Shaw SJ, Burlingame MA, Horwitz SB, Myles DC. Design, synthesis, and evaluation of carbamate-substituted analogues of (+)-discodermolide. Organic Letters. 7: 311-4. PMID 15646985 DOI: 10.1021/Ol047686A  0.619
2004 Burlingame MA, Shaw SJ, Sundermann KF, Zhang D, Petryka J, Mendoza E, Liu F, Myles DC, LaMarche MJ, Hirose T, Scott Freeze B, Smith AB. Design, synthesis and cytotoxicity of 7-deoxy aryl discodermolide analogues. Bioorganic & Medicinal Chemistry Letters. 14: 2335-8. PMID 15081036 DOI: 10.1016/J.Bmcl.2004.01.102  0.544
2001 Martello LA, LaMarche MJ, He L, Beauchamp TJ, Smith AB, Horwitz SB. The relationship between Taxol and (+)-discodermolide: synthetic analogs and modeling studies. Chemistry & Biology. 8: 843-55. PMID 11564553 DOI: 10.1016/S1074-5521(01)00055-2  0.476
2000 Smith AB, Beauchamp TJ, Lamarche MJ, Kaufman MD, Qiu Y, Arimoto H, Jones DR, Kobayashi K. Evolution of a gram-scale synthesis of (+)-discodermolide Journal of the American Chemical Society. 122: 8654-8664. DOI: 10.1021/Ja0015287  0.337
1999 Smith AB, Kaufman MD, Beauchamp TJ, LaMarche MJ, Arimoto H. Gram-scale synthesis of (+)-discodermolide. Organic Letters. 1: 1823-6. PMID 10836041 DOI: 10.1021/Ol9910870  0.336
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