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Chong Han, Ph.D. - Publications

Affiliations: 
2010- Small Molecule Process Chemistry Genentech, Inc., San Francisco, CA, United States 
Area:
Synthesis of complex natural products; Cu, Pd, Zr-catalyzed transformations
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24 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Xu J, Grosslight S, Mack KA, Nguyen SC, Clagg K, Lim NK, Timmerman JC, Shen J, White NA, Sirois LE, Han C, Zhang H, Sigman MS, Gosselin F. Atroposelective Negishi Coupling Optimization Guided by Multivariate Linear Regression Analysis: Asymmetric Synthesis of KRAS G12C Covalent Inhibitor GDC-6036. Journal of the American Chemical Society. PMID 36326518 DOI: 10.1021/jacs.2c09917  0.324
2021 Zell D, Kingston C, Jermaks J, Smith SR, Seeger N, Wassmer J, Sirois LE, Han C, Zhang H, Sigman MS, Gosselin F. Stereoconvergent and -divergent Synthesis of Tetrasubstituted Alkenes by Nickel-Catalyzed Cross-Couplings. Journal of the American Chemical Society. 143: 19078-19090. PMID 34735129 DOI: 10.1021/jacs.1c08399  0.33
2019 Bigler R, Mack KA, Shen J, Tosatti P, Han C, Zhang H, Scalone M, Pfaltz A, Denmark SE, Hildbrand S, Gosselin F. Asymmetric Hydrogenation of Unfunctionalized, Tetrasubstituted, Acyclic Olefins. Angewandte Chemie (International Ed. in English). PMID 31794118 DOI: 10.1002/Anie.201912640  0.338
2019 Wong N, Petronijević F, Hong AY, Linghu X, Kelly SM, Hou H, Cravillion T, Lim NK, Robinson SJ, Han C, Molinaro C, Sowell CG, Gosselin F. Stereocontrolled Synthesis of Arylomycin-Based Gram-Negative Antibiotic GDC-5338. Organic Letters. PMID 31668077 DOI: 10.1021/Acs.Orglett.9B03481  0.429
2019 Han C, Alabanza LM, Kelly SM, Orsi DL, Gosselin F, Altman RA. BBDFA: A Practical Reagent for Trifluoromethylation of Allylic and Benzylic Alcohols on Preparative Scale Organic Process Research & Development. 23: 1695-1702. DOI: 10.1021/Acs.Oprd.9B00201  0.599
2019 Han C, Kelly SM, Cravillion T, Savage SJ, Nguyen T, Gosselin F. Synthesis of PI3K inhibitor GDC-0077 via a stereocontrolled N-arylation of α-amino acids Tetrahedron. 75: 4351-4357. DOI: 10.1016/J.Tet.2019.04.057  0.461
2018 Savage S, McClory A, Zhang H, Cravillion T, Lim NK, Masui C, Robinson SJ, Han C, Ochs C, Rege PD, Gosselin F. Synthesis of Selective Estrogen Receptor Degrader GDC-0810 via Stereocontrolled Assembly of a Tetrasubstituted All-Carbon Olefin. The Journal of Organic Chemistry. PMID 30200756 DOI: 10.1021/Acs.Joc.8B01551  0.41
2018 Young IS, Glass AL, Cravillion T, Han C, Zhang H, Gosselin F. Palladium-Catalyzed Site-Selective Amidation of Dichloroazines. Organic Letters. PMID 29944383 DOI: 10.1021/Acs.Orglett.8B01483  0.386
2018 Dalziel ME, Deichert JA, Carrera DE, Beaudry D, Han C, Zhang H, Angelaud R. Magnesium Ethoxide Promoted Conversion of Nitriles to Amidines and Its Application in 5,6-Dihydroimidazobenzoxazepine Synthesis. Organic Letters. PMID 29687714 DOI: 10.1021/Acs.Orglett.8B00824  0.38
2018 Lim NK, Cravillion T, Savage S, McClory A, Han C, Zhang H, DiPasquale A, Gosselin F. Synthesis of a Selective Estrogen Receptor Degrader via a Stereospecific Elimination Approach. Organic Letters. PMID 29397753 DOI: 10.1021/Acs.Orglett.8B00035  0.36
2018 Zhang H, Cravillion T, Lim N, Tian Q, Beaudry D, Defreese JL, Fettes A, James P, Linder D, Malhotra S, Han C, Angelaud R, Gosselin F. Development of an Efficient Manufacturing Process for Reversible Bruton’s Tyrosine Kinase Inhibitor GDC-0853 Organic Process Research & Development. 22: 978-990. DOI: 10.1021/Acs.Oprd.8B00134  0.363
2018 Han C, Green K, Oehring K, Meili A, Pfeifer E, Scalone M, Gosselin F. An Efficient Through-Process for Chk1 Kinase Inhibitor GDC-0575 Organic Process Research & Development. 22: 344-350. DOI: 10.1021/Acs.Oprd.7B00388  0.35
2017 Han C, Savage S, Al-Sayah M, Yajima H, Remarchuk T, Reents R, Wirz B, Iding H, Bachmann S, Fantasia SM, Scalone M, Hell A, Hidber P, Gosselin F. Asymmetric Synthesis of Akt Kinase Inhibitor Ipatasertib. Organic Letters. PMID 28858516 DOI: 10.1021/Acs.Orglett.7B02228  0.41
2017 Li BX, Le DN, Mack KA, McClory A, Lim NK, Cravillion T, Savage S, Han C, Collum DB, Zhang H, Gosselin F. Highly Stereoselective Synthesis of Tetrasubstituted Acyclic All-carbon Olefins via Enol Tosylation and Suzuki‒Miyaura Coupling. Journal of the American Chemical Society. PMID 28715208 DOI: 10.1021/Jacs.7B05071  0.425
2017 Kelly SM, Han C, Tung L, Gosselin F. Chemoselective Copper-Catalyzed Ullmann-Type Coupling of Oxazolidinones with Bromoiodoarenes. Organic Letters. PMID 28530104 DOI: 10.1021/Acs.Orglett.7B01304  0.402
2017 Han C, Green K, Pfeifer E, Gosselin F. Highly Regioselective and Practical Synthesis of 5-Bromo-4-chloro-3-nitro-7-azaindole Organic Process Research & Development. 21: 664-668. DOI: 10.1021/Acs.Oprd.7B00060  0.413
2016 Pushkarskaya E, Wong B, Han C, Capomolla S, Gu C, Stoltz BM, Zhang H. Single-step synthesis of 3-hydroxycarbazoles by annulation of electron-rich anilines and quinones Tetrahedron Letters. 57: 5653-5657. DOI: 10.1016/J.Tetlet.2016.11.009  0.332
2015 Shvartzvald Y, Udalski A, Gould A, Han C, Bozza V, Friedmann M, Hundertmark M, Beichman C, Bryden G, Novati SC, Carey S, Fausnaugh M, Gaudi BS, Henderson CB, Kerr T, et al. SPITZER MICROLENS MEASUREMENT of A MASSIVE REMNANT in A WELL-SEPARATED BINARY Astrophysical Journal. 814. DOI: 10.1088/0004-637X/814/2/111  0.387
2014 Yang Y, Niedermann K, Han C, Buchwald SL. Highly selective palladium-catalyzed cross-coupling of secondary alkylzinc reagents with heteroaryl halides. Organic Letters. 16: 4638-41. PMID 25153332 DOI: 10.1021/Ol502230P  0.504
2009 Han C, Buchwald SL. Negishi coupling of secondary alkylzinc halides with aryl bromides and chlorides. Journal of the American Chemical Society. 131: 7532-3. PMID 19441851 DOI: 10.1021/Ja902046M  0.51
2009 Han C, Rangarajan S, Voukides AC, Beeler AB, Johnson R, Porco JA. Reaction discovery employing macrocycles: transannular cyclizations of macrocyclic bis-lactams. Organic Letters. 11: 413-6. PMID 19102683 DOI: 10.1021/Ol802729F  0.606
2007 Han C, Porco JA. Synthesis of carbamates and ureas using Zr(IV)-catalyzed exchange processes. Organic Letters. 9: 1517-20. PMID 17358074 DOI: 10.1021/ol0702728  0.551
2005 Han C, Lee JP, Lobkovsky E, Porco JA. Catalytic ester-amide exchange using group (IV) metal alkoxide-activator complexes. Journal of the American Chemical Society. 127: 10039-44. PMID 16011366 DOI: 10.1021/Ja0527976  0.55
2004 Han C, Shen R, Su S, Porco JA. Copper-mediated synthesis of N-acyl vinylogous carbamic acids and derivatives: synthesis of the antibiotic CJ-15,801. Organic Letters. 6: 27-30. PMID 14703342 DOI: 10.1021/Ol0360041  0.633
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