Eric Lai - Publications

Affiliations: 
Developmental Biology Sloan-Kettering Institute, New York, NY, United States 

148 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Mohammed J, Flynt AS, Panzarino AM, Mondal MMH, DeCruz M, Siepel A, Lai EC. Erratum: Deep experimental profiling of microRNA diversity, deployment, and evolution across the genus. Genome Research. 29: 881. PMID 31043510 DOI: 10.1101/gr.250654.119  1
2018 Lin CJ, Hu F, Dubruille R, Vedanayagam J, Wen J, Smibert P, Loppin B, Lai EC. The hpRNA/RNAi Pathway Is Essential to Resolve Intragenomic Conflict in the Drosophila Male Germline. Developmental Cell. 46: 316-326.e5. PMID 30086302 DOI: 10.1016/j.devcel.2018.07.004  1
2018 Duan H, de Navas LF, Hu F, Sun K, Mavromatakis YE, Viets K, Zhou C, Kavaler J, Johnston RJ, Tomlinson A, Lai EC. Thecluster represses receptor tyrosine kinase signaling to determine cell fates in theeye. Development (Cambridge, England). PMID 29540498 DOI: 10.1242/dev.159053  0.6
2018 Jee D, Yang JS, Park SM, Farmer DT, Wen J, Chou T, Chow A, McManus MT, Kharas MG, Lai EC. Dual Strategies for Argonaute2-Mediated Biogenesis of Erythroid miRNAs Underlie Conserved Requirements for Slicing in Mammals. Molecular Cell. 69: 265-278.e6. PMID 29351846 DOI: 10.1016/j.molcel.2017.12.027  0.36
2017 Mohammed J, Flynt AS, Panzarino AM, Mondal MMH, DeCruz M, Siepel A, Lai EC. Deep experimental profiling of microRNA diversity, deployment, and evolution across the Drosophila genus. Genome Research. PMID 29233922 DOI: 10.1101/gr.226068.117  1
2017 Kavaler J, Duan H, Aradhya R, de Navas LF, Joseph B, Shklyar B, Lai EC. miRNA suppression of a Notch repressor directs non-neuronal fate in Drosophila mechanosensory organs. The Journal of Cell Biology. PMID 29196461 DOI: 10.1083/jcb.201706101  0.6
2017 Sanfilippo P, Wen J, Lai EC. Landscape and evolution of tissue-specific alternative polyadenylation across Drosophila species. Genome Biology. 18: 229. PMID 29191225 DOI: 10.1186/s13059-017-1358-0  0.6
2017 Kondo S, Vedanayagam J, Mohammed J, Eizadshenass S, Kan L, Pang N, Aradhya R, Siepel A, Steinhauer J, Lai EC. New genes often acquire male-specific functions but rarely become essential in Drosophila. Genes & Development. 31: 1841-1846. PMID 29051389 DOI: 10.1101/gad.303131.117  0.56
2017 Yao L, Wang S, Orzechowski-Westholm J, Dai Q, Matsuda R, Hosono C, Bray S, Lai EC, Samakovlis C. Genome-wide identification of Grainy head targets in Drosophila reveals regulatory interactions with the POU-domain transcription factor, Vvl. Development (Cambridge, England). PMID 28760809 DOI: 10.1242/dev.143297  0.4
2017 Sanfilippo P, Miura P, Lai EC. Genome-wide profiling of the 3' ends of polyadenylated RNAs. Methods (San Diego, Calif.). PMID 28602807 DOI: 10.1016/j.ymeth.2017.06.003  0.6
2017 Sanfilippo P, Smibert P, Duan H, Lai EC. Correction: Neural specificity of the RNA-binding protein Elav is achieved by post-transcriptional repression in non-neural tissues. Development (Cambridge, England). 144: 1578. PMID 28400435 DOI: 10.1242/dev.151753  1
2016 Lin CJ, Wen J, Bejarano F, Hu F, Bortolamiol-Becet D, Kan L, Sanfilippo P, Kondo S, Lai EC. Characterization of a TUTase/nuclease complex required for Drosophila gametogenesis. Rna (New York, N.Y.). PMID 27974621 DOI: 10.1261/rna.059527.116  0.68
2016 Sanfilippo P, Smibert P, Duan H, Lai EC. Neural specificity of the RNA binding protein Elav is achieved by post-transcriptional repression in non-neural tissues. Development (Cambridge, England). PMID 27802174 DOI: 10.1242/dev.141978  1
2016 Garaulet DL, Sun K, Li W, Wen J, Panzarino AM, O'Neil JL, Hiesinger PR, Young MW, Lai EC. miR-124 Regulates Diverse Aspects of Rhythmic Behavior in Drosophila. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 3414-21. PMID 27013671 DOI: 10.1523/JNEUROSCI.3287-15.2016  1
2016 Zhang L, Zheng XE, Zou F, Shang Y, Meng W, Lai E, Xu Z, Liu Y, Zhao J. A highly selective and sensitive near-infrared fluorescent probe for imaging of hydrogen sulphide in living cells and mice. Scientific Reports. 6: 18868. PMID 26743682 DOI: 10.1038/srep18868  0.52
2015 Lin CJ, Smibert P, Zhao X, Hu JF, Ramroop J, Kellner SM, Benton MA, Govind S, Dedon PC, Sternglanz R, Lai EC. An extensive allelic series of Drosophila kae1 mutants reveals diverse and tissue-specific requirements for t6A biogenesis. Rna (New York, N.Y.). PMID 26516084 DOI: 10.1261/rna.053934.115  1
2015 Wen J, Ladewig E, Shenker S, Mohammed J, Lai EC. Analysis of Nearly One Thousand Mammalian Mirtrons Reveals Novel Features of Dicer Substrates. Plos Computational Biology. 11: e1004441. PMID 26325366 DOI: 10.1371/journal.pcbi.1004441  1
2015 Garaulet DL, Lai EC. Hox miRNA regulation within the Drosophila Bithorax complex: Patterning behavior. Mechanisms of Development. PMID 26311219 DOI: 10.1016/j.mod.2015.08.006  1
2015 Bortolamiol-Becet D, Hu F, Jee D, Wen J, Okamura K, Lin CJ, Ameres SL, Lai EC. Selective Suppression of the Splicing-Mediated MicroRNA Pathway by the Terminal Uridyltransferase Tailor. Molecular Cell. PMID 26145174 DOI: 10.1016/j.molcel.2015.05.034  1
2015 Lai EC, Man KK, Chaiyakunapruk N, Cheng CL, Chien HC, Chui CS, Dilokthornsakul P, Hardy NC, Hsieh CY, Hsu CY, Kubota K, Lin TC, Liu Y, Park BJ, Pratt N, et al. Databases in the Asia-Pacific Region: The Potential for a Distributed Network Approach. Epidemiology (Cambridge, Mass.). PMID 26133022 DOI: 10.1097/EDE.0000000000000325  0.52
2015 Fulga TA, McNeill EM, Binari R, Yelick J, Blanche A, Booker M, Steinkraus BR, Schnall-Levin M, Zhao Y, DeLuca T, Bejarano F, Han Z, Lai EC, Wall DP, Perrimon N, et al. A transgenic resource for conditional competitive inhibition of conserved Drosophila microRNAs. Nature Communications. 6: 7279. PMID 26081261 DOI: 10.1038/ncomms8279  0.68
2015 Sun K, Jee D, de Navas LF, Duan H, Lai EC. Multiple In Vivo Biological Processes Are Mediated by Functionally Redundant Activities of Drosophila mir-279 and mir-996. Plos Genetics. 11: e1005245. PMID 26042831 DOI: 10.1371/journal.pgen.1005245  1
2015 Lai EC. Two decades of miRNA biology: lessons and challenges. Rna (New York, N.Y.). 21: 675-7. PMID 25780186 DOI: 10.1261/rna.051193.115  1
2015 Chak LL, Mohammed J, Lai EC, Tucker-Kellogg G, Okamura K. A deeply conserved, noncanonical miRNA hosted by ribosomal DNA. Rna (New York, N.Y.). 21: 375-84. PMID 25605965 DOI: 10.1261/rna.049098.114  1
2015 Dai Q, Ren A, Westholm JO, Duan H, Patel DJ, Lai EC. Common and distinct DNA-binding and regulatory activities of the BEN-solo transcription factor family. Genes & Development. 29: 48-62. PMID 25561495 DOI: 10.1101/gad.252122.114  1
2015 Wen J, Duan H, Bejarano F, Okamura K, Fabian L, Brill JA, Bortolamiol-Becet D, Martin R, Ruby JG, Lai EC. Adaptive regulation of testis gene expression and control of male fertility by the Drosophila harpin RNA pathway. Molecular Cell. 57: 165-78. PMID 25544562 DOI: 10.1016/j.molcel.2014.11.025  1
2015 Yeh CC, Chang JZ, Yang WH, Chang HH, Lai EH, Kuo MY. NADPH oxidase 4 is involved in the triethylene glycol dimethacrylate-induced reactive oxygen species and apoptosis in human embryonic palatal mesenchymal and dental pulp cells. Clinical Oral Investigations. 19: 1463-71. PMID 25467236 DOI: 10.1007/s00784-014-1370-7  0.44
2015 Shenker S, Miura P, Sanfilippo P, Lai EC. IsoSCM: improved and alternative 3' UTR annotation using multiple change-point inference. Rna (New York, N.Y.). 21: 14-27. PMID 25406361 DOI: 10.1261/rna.046037.114  1
2015 Tsai SSL, Sar JIC, Chang JZC, Yu SH, Lai EHH, Lin CP. Dental education development reflection from an objective structured clinical examination Journal of Dental Sciences. 10: 248-252. DOI: 10.1016/j.jds.2014.12.001  0.44
2015 Hsu TC, Tsai SSL, Chang JZC, Yu SH, Lai EHH, Lin CP. Core clinical competencies for dental graduates in Taiwan: Considering local and cultural issues Journal of Dental Sciences. 10: 161-166. DOI: 10.1016/j.jds.2014.05.005  0.44
2015 Liu YJ, Sar JIC, Chen YY, Chiang YY, Lai EHH, Chen WP, Lin CP. Mechanical properties of temporary anchorage device Journal of Dental Sciences. 10: 68-73. DOI: 10.1016/j.jds.2013.09.004  0.44
2015 Liu PH, Lai EHH, Yang H, Chang JZC. Orthodontic treatment of a complete transposed impacted maxillary canine Journal of Dental Sciences. 10: 102-108. DOI: 10.1016/j.jds.2013.02.015  0.44
2014 Westholm JO, Miura P, Olson S, Shenker S, Joseph B, Sanfilippo P, Celniker SE, Graveley BR, Lai EC. Genome-wide analysis of drosophila circular RNAs reveals their structural and sequence properties and age-dependent neural accumulation. Cell Reports. 9: 1966-80. PMID 25544350 DOI: 10.1016/j.celrep.2014.10.062  1
2014 Hu F, Lai EC, Okamura K. A signaling-induced switch in dicer localization and function. Developmental Cell. 31: 523-4. PMID 25490263 DOI: 10.1016/j.devcel.2014.11.032  0.6
2014 Milton CC, Grusche FA, Degoutin JL, Yu E, Dai Q, Lai EC, Harvey KF. The Hippo pathway regulates hematopoiesis in Drosophila melanogaster. Current Biology : Cb. 24: 2673-80. PMID 25454587 DOI: 10.1016/j.cub.2014.10.031  0.6
2014 Mohammed J, Siepel A, Lai EC. Diverse modes of evolutionary emergence and flux of conserved microRNA clusters. Rna (New York, N.Y.). 20: 1850-63. PMID 25332374 DOI: 10.1261/rna.046805.114  1
2014 Chen YJ, Zhen ZJ, Chen HW, Lai EC, Deng FW, Li QH, Lau WY. Laparoscopic liver resection under hemihepatic vascular inflow occlusion using the lowering of hilar plate approach. Hepatobiliary & Pancreatic Diseases International : Hbpd Int. 13: 508-12. PMID 25308361 DOI: 10.1016/S1499-3872(14)60293-9  0.44
2014 Gerstein MB, Rozowsky J, Yan KK, Wang D, Cheng C, Brown JB, Davis CA, Hillier L, Sisu C, Li JJ, Pei B, Harmanci AO, Duff MO, Djebali S, Alexander RP, ... ... Lai E, et al. Comparative analysis of the transcriptome across distant species. Nature. 512: 445-8. PMID 25164755 DOI: 10.1038/nature13424  0.6
2014 Fagegaltier D, König A, Gordon A, Lai EC, Gingeras TR, Hannon GJ, Shcherbata HR. A genome-wide survey of sexually dimorphic expression of Drosophila miRNAs identifies the steroid hormone-induced miRNA let-7 as a regulator of sexual identity. Genetics. 198: 647-68. PMID 25081570 DOI: 10.1534/genetics.114.169268  0.48
2014 Wen J, Mohammed J, Bortolamiol-Becet D, Tsai H, Robine N, Westholm JO, Ladewig E, Dai Q, Okamura K, Flynt AS, Zhang D, Andrews J, Cherbas L, Kaufman TC, Cherbas P, ... ... Lai EC, et al. Diversity of miRNAs, siRNAs, and piRNAs across 25 Drosophila cell lines. Genome Research. 24: 1236-50. PMID 24985917 DOI: 10.1101/gr.161554.113  0.6
2014 Mohammed J, Bortolamiol-Becet D, Flynt AS, Gronau I, Siepel A, Lai EC. Adaptive evolution of testis-specific, recently evolved, clustered miRNAs in Drosophila. Rna (New York, N.Y.). 20: 1195-209. PMID 24942624 DOI: 10.1261/rna.044644.114  1
2014 Garaulet DL, Castellanos MC, Bejarano F, Sanfilippo P, Tyler DM, Allan DW, Sánchez-Herrero E, Lai EC. Homeotic function of Drosophila Bithorax-complex miRNAs mediates fertility by restricting multiple Hox genes and TALE cofactors in the CNS. Developmental Cell. 29: 635-48. PMID 24909902 DOI: 10.1016/j.devcel.2014.04.023  0.6
2014 Miura P, Sanfilippo P, Shenker S, Lai EC. Alternative polyadenylation in the nervous system: to what lengths will 3' UTR extensions take us? Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 36: 766-77. PMID 24903459 DOI: 10.1002/bies.201300174  0.6
2014 Jee D, Lai EC. Alteration of miRNA activity via context-specific modifications of Argonaute proteins. Trends in Cell Biology. 24: 546-53. PMID 24865524 DOI: 10.1016/j.tcb.2014.04.008  1
2014 Chen YJ, Lai EC, Lau WY, Chen XP. Enteric reconstruction of pancreatic stump following pancreaticoduodenectomy: a review of the literature. International Journal of Surgery (London, England). 12: 706-11. PMID 24851718 DOI: 10.1016/j.ijsu.2014.05.060  0.44
2014 Lauring B, Li XS, Liu Y, Corr C, Lazarus N, Cote J, Larson P, Levonas AO, Lasseter KC, Preston RA, Smith WB, Lai E, Wagner JA. Influence of renal and hepatic impairment on the pharmacokinetics of anacetrapib. Journal of Clinical Pharmacology. 54: 1247-55. PMID 24782116 DOI: 10.1002/jcph.320  0.52
2014 Brown JB, Boley N, Eisman R, May GE, Stoiber MH, Duff MO, Booth BW, Wen J, Park S, Suzuki AM, Wan KH, Yu C, Zhang D, Carlson JW, Cherbas L, ... ... Lai EC, et al. Diversity and dynamics of the Drosophila transcriptome. Nature. 512: 393-9. PMID 24670639 DOI: 10.1038/nature12962  0.6
2014 Lauring B, Liu Y, Li XS, Larson P, Moreau A, Farmer HF, Johnson-Levonas AO, Wagner JA, Lai E. Single therapeutic and supratherapeutic doses of anacetrapib, a cholesteryl ester transfer protein inhibitor, do not prolong the QTcF interval in healthy volunteers. Journal of Clinical Pharmacology. 54: 765-75. PMID 24615657 DOI: 10.1002/jcph.278  0.52
2014 Yang JS, Smibert P, Westholm JO, Jee D, Maurin T, Lai EC. Intertwined pathways for Argonaute-mediated microRNA biogenesis in Drosophila. Nucleic Acids Research. 42: 1987-2002. PMID 24220090 DOI: 10.1093/nar/gkt1038  0.6
2014 Aoki T, Wolle D, Preger-Ben Noon E, Dai Q, Lai EC, Schedl P. Bi-functional cross-linking reagents efficiently capture protein-DNA complexes in Drosophila embryos. Fly. 8: 43-51. PMID 24135698 DOI: 10.4161/fly.26805  1
2013 Wang D, Zhang Z, O'Loughlin E, Wang L, Fan X, Lai EC, Yi R. MicroRNA-205 controls neonatal expansion of skin stem cells by modulating the PI(3)K pathway. Nature Cell Biology. 15: 1153-63. PMID 23974039 DOI: 10.1038/ncb2827  1
2013 Jin Z, Flynt AS, Lai EC. Drosophila piwi mutants exhibit germline stem cell tumors that are sustained by elevated Dpp signaling. Current Biology : Cb. 23: 1442-8. PMID 23891114 DOI: 10.1016/j.cub.2013.06.021  1
2013 Mohammed J, Flynt AS, Siepel A, Lai EC. The impact of age, biogenesis, and genomic clustering on Drosophila microRNA evolution. Rna (New York, N.Y.). 19: 1295-308. PMID 23882112 DOI: 10.1261/rna.039248.113  1
2013 Pancratov R, Peng F, Smibert P, Yang S, Olson ER, Guha-Gilford C, Kapoor AJ, Liang FX, Lai EC, Flaherty MS, DasgGupta R. The miR-310/13 cluster antagonizes β-catenin function in the regulation of germ and somatic cell differentiation in the Drosophila testis. Development (Cambridge, England). 140: 2904-16. PMID 23821034 DOI: 10.1242/dev.092817  1
2013 Sun K, Lai EC. Adult-specific functions of animal microRNAs. Nature Reviews. Genetics. 14: 535-48. PMID 23817310 DOI: 10.1038/nrg3471  1
2013 Smibert P, Yang JS, Azzam G, Liu JL, Lai EC. Homeostatic control of Argonaute stability by microRNA availability. Nature Structural & Molecular Biology. 20: 789-95. PMID 23708604 DOI: 10.1038/nsmb.2606  1
2013 Dai Q, Andreu-Agullo C, Insolera R, Wong LC, Shi SH, Lai EC. BEND6 is a nuclear antagonist of Notch signaling during self-renewal of neural stem cells. Development (Cambridge, England). 140: 1892-902. PMID 23571214 DOI: 10.1242/dev.087502  1
2013 Okamura K, Ladewig E, Zhou L, Lai EC. Functional small RNAs are generated from select miRNA hairpin loops in flies and mammals. Genes & Development. 27: 778-92. PMID 23535236 DOI: 10.1101/gad.211698.112  1
2013 Miura P, Shenker S, Andreu-Agullo C, Westholm JO, Lai EC. Widespread and extensive lengthening of 3' UTRs in the mammalian brain. Genome Research. 23: 812-25. PMID 23520388 DOI: 10.1101/gr.146886.112  1
2013 Dai Q, Ren A, Westholm JO, Serganov AA, Patel DJ, Lai EC. The BEN domain is a novel sequence-specific DNA-binding domain conserved in neural transcriptional repressors. Genes & Development. 27: 602-14. PMID 23468431 DOI: 10.1101/gad.213314.113  1
2013 Arif S, Murat S, Almudi I, Nunes MD, Bortolamiol-Becet D, McGregor NS, Currie JM, Hughes H, Ronshaugen M, Sucena É, Lai EC, Schlötterer C, McGregor AP. Evolution of mir-92a underlies natural morphological variation in Drosophila melanogaster. Current Biology : Cb. 23: 523-8. PMID 23453955 DOI: 10.1016/j.cub.2013.02.018  1
2013 Chang JZC, Chang WC, Chen KH, Chen YJ, Lai EHH, Yao CCJ. How to achieve proper overbite - Lessons from natural dentoalveolar compensation Journal of Dental Sciences. 8: 341-347. DOI: 10.1016/j.jds.2013.02.013  0.44
2013 Smibert P, Miura P, Westholm JO, Shenker S, May G, Duff MO, Zhang D, Eads BD, Carlson J, Brown JB, Eisman RC, Andrews J, Kaufman T, Cherbas P, Celniker SE, ... ... Lai EC, et al. Errata to Global patterns of tissue-specific alternative polyadenylation in drosophila [Cell Reports, 1 (2012) 277-289] Cell Reports. 3: 969. DOI: 10.1016/j.celrep.2013.03.022  1
2012 Maurin T, Cazalla D, Yang S, Bortolamiol-Becet D, Lai EC. RNase III-independent microRNA biogenesis in mammalian cells. Rna (New York, N.Y.). 18: 2166-73. PMID 23097423 DOI: 10.1261/rna.036194.112  1
2012 Ladewig E, Okamura K, Flynt AS, Westholm JO, Lai EC. Discovery of hundreds of mirtrons in mouse and human small RNA data. Genome Research. 22: 1634-45. PMID 22955976 DOI: 10.1101/gr.133553.111  1
2012 Bejarano F, Bortolamiol-Becet D, Dai Q, Sun K, Saj A, Chou YT, Raleigh DR, Kim K, Ni JQ, Duan H, Yang JS, Fulga TA, Van Vactor D, Perrimon N, Lai EC. A genome-wide transgenic resource for conditional expression of Drosophila microRNAs. Development (Cambridge, England). 139: 2821-31. PMID 22745315 DOI: 10.1242/dev.079939  0.6
2012 Smibert P, Miura P, Westholm JO, Shenker S, May G, Duff MO, Zhang D, Eads BD, Carlson J, Brown JB, Eisman RC, Andrews J, Kaufman T, Cherbas P, Celniker SE, ... ... Lai EC, et al. Global patterns of tissue-specific alternative polyadenylation in Drosophila. Cell Reports. 1: 277-89. PMID 22685694 DOI: 10.1016/j.celrep.2012.01.001  1
2012 Yang JS, Maurin T, Lai EC. Functional parameters of Dicer-independent microRNA biogenesis. Rna (New York, N.Y.). 18: 945-57. PMID 22461413 DOI: 10.1261/rna.032938.112  1
2012 Azzam G, Smibert P, Lai EC, Liu JL. Drosophila Argonaute 1 and its miRNA biogenesis partners are required for oocyte formation and germline cell division. Developmental Biology. 365: 384-94. PMID 22445511 DOI: 10.1016/j.ydbio.2012.03.005  1
2012 Dai Q, Smibert P, Lai EC. Exploiting Drosophila genetics to understand microRNA function and regulation. Current Topics in Developmental Biology. 99: 201-35. PMID 22365740 DOI: 10.1016/B978-0-12-387038-4.00008-2  1
2012 Sun K, Westholm JO, Tsurudome K, Hagen JW, Lu Y, Kohwi M, Betel D, Gao FB, Haghighi AP, Doe CQ, Lai EC. Neurophysiological defects and neuronal gene deregulation in Drosophila mir-124 mutants. Plos Genetics. 8: e1002515. PMID 22347817 DOI: 10.1371/journal.pgen.1002515  1
2012 Andreu-Agullo C, Maurin T, Thompson CB, Lai EC. Ars2 maintains neural stem-cell identity through direct transcriptional activation of Sox2. Nature. 481: 195-8. PMID 22198669 DOI: 10.1038/nature10712  1
2012 Westholm JO, Ladewig E, Okamura K, Robine N, Lai EC. Common and distinct patterns of terminal modifications to mirtrons and canonical microRNAs. Rna (New York, N.Y.). 18: 177-92. PMID 22190743 DOI: 10.1261/rna.030627.111  1
2011 Smibert P, Bejarano F, Wang D, Garaulet DL, Yang JS, Martin R, Bortolamiol-Becet D, Robine N, Hiesinger PR, Lai EC. A Drosophila genetic screen yields allelic series of core microRNA biogenesis factors and reveals post-developmental roles for microRNAs. Rna (New York, N.Y.). 17: 1997-2010. PMID 21947201 DOI: 10.1261/rna.2983511  1
2011 Yang JS, Lai EC. Alternative miRNA biogenesis pathways and the interpretation of core miRNA pathway mutants. Molecular Cell. 43: 892-903. PMID 21925378 DOI: 10.1016/j.molcel.2011.07.024  1
2011 Duan H, Dai Q, Kavaler J, Bejarano F, Medranda G, Nègre N, Lai EC. Insensitive is a corepressor for Suppressor of Hairless and regulates Notch signalling during neural development. The Embo Journal. 30: 3120-33. PMID 21765394 DOI: 10.1038/emboj.2011.218  1
2011 Rissland OS, Lai EC. RNA silencing in Monterey. Development (Cambridge, England). 138: 3093-102. PMID 21750025 DOI: 10.1242/dev.065284  1
2011 Westholm JO, Lai EC. Mirtrons: microRNA biogenesis via splicing. Biochimie. 93: 1897-904. PMID 21712066 DOI: 10.1016/j.biochi.2011.06.017  1
2011 Flynt AS, Lai EC. RNAi in Xenopus: look before you leap. Genes & Development. 25: 1105-8. PMID 21632820 DOI: 10.1101/gad.2062911  1
2011 Saj A, Lai EC. Control of microRNA biogenesis and transcription by cell signaling pathways. Current Opinion in Genetics & Development. 21: 504-10. PMID 21592778 DOI: 10.1016/j.gde.2011.04.010  1
2011 Dávalos A, Goedeke L, Smibert P, Ramírez CM, Warrier NP, Andreo U, Cirera-Salinas D, Rayner K, Suresh U, Pastor-Pareja JC, Esplugues E, Fisher EA, Penalva LO, Moore KJ, Suárez Y, ... Lai EC, et al. miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling. Proceedings of the National Academy of Sciences of the United States of America. 108: 9232-7. PMID 21576456 DOI: 10.1073/pnas.1102281108  1
2011 Axtell MJ, Westholm JO, Lai EC. Vive la différence: biogenesis and evolution of microRNAs in plants and animals. Genome Biology. 12: 221. PMID 21554756 DOI: 10.1186/gb-2011-12-4-221  1
2011 Berezikov E, Robine N, Samsonova A, Westholm JO, Naqvi A, Hung JH, Okamura K, Dai Q, Bortolamiol-Becet D, Martin R, Zhao Y, Zamore PD, Hannon GJ, Marra MA, Weng Z, ... ... Lai EC, et al. Deep annotation of Drosophila melanogaster microRNAs yields insights into their processing, modification, and emergence. Genome Research. 21: 203-15. PMID 21177969 DOI: 10.1101/gr.116657.110  1
2011 Chung WJ, Agius P, Westholm JO, Chen M, Okamura K, Robine N, Leslie CS, Lai EC. Computational and experimental identification of mirtrons in Drosophila melanogaster and Caenorhabditis elegans. Genome Research. 21: 286-300. PMID 21177960 DOI: 10.1101/gr.113050.110  1
2011 Yang JS, Phillips MD, Betel D, Mu P, Ventura A, Siepel AC, Chen KC, Lai EC. Widespread regulatory activity of vertebrate microRNA* species. Rna (New York, N.Y.). 17: 312-26. PMID 21177881 DOI: 10.1261/rna.2537911  1
2011 Okamura K, Robine N, Liu Y, Liu Q, Lai EC. R2D2 organizes small regulatory RNA pathways in Drosophila. Molecular and Cellular Biology. 31: 884-96. PMID 21135122 DOI: 10.1128/MCB.01141-10  1
2010 Hain D, Bettencourt BR, Okamura K, Csorba T, Meyer W, Jin Z, Biggerstaff J, Siomi H, Hutvagner G, Lai EC, Welte M, Müller HA. Natural variation of the amino-terminal glutamine-rich domain in Drosophila argonaute2 is not associated with developmental defects. Plos One. 5: e15264. PMID 21253006 DOI: 10.1371/journal.pone.0015264  1
2010 Yao J, Hennessey T, Flynt A, Lai E, Beal MF, Lin MT. MicroRNA-related cofilin abnormality in Alzheimer's disease. Plos One. 5: e15546. PMID 21179570 DOI: 10.1371/journal.pone.0015546  1
2010 Gerstein MB, Lu ZJ, Van Nostrand EL, Cheng C, Arshinoff BI, Liu T, Yip KY, Robilotto R, Rechtsteiner A, Ikegami K, Alves P, Chateigner A, Perry M, Morris M, Auerbach RK, ... ... Lai EC, et al. Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project. Science (New York, N.Y.). 330: 1775-87. PMID 21177976 DOI: 10.1126/science.1196914  1
2010 Roy S, Ernst J, Kharchenko PV, Kheradpour P, Negre N, Eaton ML, Landolin JM, Bristow CA, Ma L, Lin MF, Washietl S, Arshinoff BI, Ay F, Meyer PE, ... ... Lai EC, et al. Identification of functional elements and regulatory circuits by Drosophila modENCODE. Science (New York, N.Y.). 330: 1787-97. PMID 21177974 DOI: 10.1126/science.1198374  1
2010 Tsurudome K, Tsang K, Liao EH, Ball R, Penney J, Yang JS, Elazzouzi F, He T, Chishti A, Lnenicka G, Lai EC, Haghighi AP. The Drosophila miR-310 cluster negatively regulates synaptic strength at the neuromuscular junction. Neuron. 68: 879-93. PMID 21145002 DOI: 10.1016/j.neuron.2010.11.016  1
2010 Yang JS, Lai EC. Dicer-independent, Ago2-mediated microRNA biogenesis in vertebrates. Cell Cycle (Georgetown, Tex.). 9: 4455-60. PMID 21088485 DOI: 10.4161/cc.9.22.13958  1
2010 Rouget C, Papin C, Boureux A, Meunier AC, Franco B, Robine N, Lai EC, Pelisson A, Simonelig M. Maternal mRNA deadenylation and decay by the piRNA pathway in the early Drosophila embryo. Nature. 467: 1128-32. PMID 20953170 DOI: 10.1038/nature09465  1
2010 Yang JS, Maurin T, Robine N, Rasmussen KD, Jeffrey KL, Chandwani R, Papapetrou EP, Sadelain M, O'Carroll D, Lai EC. Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis. Proceedings of the National Academy of Sciences of the United States of America. 107: 15163-8. PMID 20699384 DOI: 10.1073/pnas.1006432107  1
2010 Flynt AS, Greimann JC, Chung WJ, Lima CD, Lai EC. MicroRNA biogenesis via splicing and exosome-mediated trimming in Drosophila. Molecular Cell. 38: 900-7. PMID 20620959 DOI: 10.1016/j.molcel.2010.06.014  1
2010 Okamura K, Lai EC. A deathly DNase activity for dicer. Developmental Cell. 18: 692-4. PMID 20493803 DOI: 10.1016/j.devcel.2010.05.004  1
2010 Büssing I, Yang JS, Lai EC, Grohans H. The nuclear export receptor XPO-1 supports primary miRNA processing in C. elegans and Drosophila Embo Journal. 29: 1830-1839. PMID 20436454 DOI: 10.1038/emboj.2010.82  1
2010 Smibert P, Lai EC. A view from Drosophila: multiple biological functions for individual microRNAs. Seminars in Cell & Developmental Biology. 21: 745-53. PMID 20211749 DOI: 10.1016/j.semcdb.2010.03.001  1
2010 Wu Q, Luo Y, Lu R, Lau N, Lai EC, Li WX, Ding SW. Virus discovery by deep sequencing and assembly of virus-derived small silencing RNAs Proceedings of the National Academy of Sciences of the United States of America. 107: 1606-1611. PMID 20080648 DOI: 10.1073/pnas.0911353107  1
2010 Berezikov E, Liu N, Flynt AS, Hodges E, Rooks M, Hannon GJ, Lai EC. Evolutionary flux of canonical microRNAs and mirtrons in Drosophila. Nature Genetics. 42: 6-9; author reply 9-. PMID 20037610 DOI: 10.1038/ng0110-6  1
2010 Bejarano F, Smibert P, Lai EC. miR-9a prevents apoptosis during wing development by repressing Drosophila LIM-only. Developmental Biology. 338: 63-73. PMID 19944676 DOI: 10.1016/j.ydbio.2009.11.025  1
2009 Robine N, Lau NC, Balla S, Jin Z, Okamura K, Kuramochi-Miyagawa S, Blower MD, Lai EC. A broadly conserved pathway generates 3'UTR-directed primary piRNAs. Current Biology : Cb. 19: 2066-76. PMID 20022248 DOI: 10.1016/j.cub.2009.11.064  1
2009 Okamura K, Lai EC. [Diversity and complexity of dicer dependent small RNA networks in animals]. Seikagaku. the Journal of Japanese Biochemical Society. 81: 904-9. PMID 19928532  1
2009 Okamura K, Liu N, Lai EC. Distinct mechanisms for microRNA strand selection by Drosophila Argonautes. Molecular Cell. 36: 431-44. PMID 19917251 DOI: 10.1016/j.molcel.2009.09.027  1
2009 Lau NC, Robine N, Martin R, Chung WJ, Niki Y, Berezikov E, Lai EC. Abundant primary piRNAs, endo-siRNAs, and microRNAs in a Drosophila ovary cell line. Genome Research. 19: 1776-85. PMID 19541914 DOI: 10.1101/gr.094896.109  1
2009 Celniker SE, Dillon LA, Gerstein MB, Gunsalus KC, Henikoff S, Karpen GH, Kellis M, Lai EC, Lieb JD, MacAlpine DM, Micklem G, Piano F, Snyder M, Stein L, White KP, et al. Unlocking the secrets of the genome. Nature. 459: 927-30. PMID 19536255 DOI: 10.1038/459927a  1
2009 Roegiers F, Kavaler J, Tolwinski N, Chou YT, Duan H, Bejarano F, Zitserman D, Lai EC. Frequent unanticipated alleles of lethal giant larvae in Drosophila second chromosome stocks. Genetics. 182: 407-10. PMID 19279324 DOI: 10.1534/genetics.109.101808  1
2009 Flynt A, Liu N, Martin R, Lai EC. Dicing of viral replication intermediates during silencing of latent Drosophila viruses. Proceedings of the National Academy of Sciences of the United States of America. 106: 5270-5. PMID 19251644 DOI: 10.1073/pnas.0813412106  1
2009 Martin R, Smibert P, Yalcin A, Tyler DM, Schäfer U, Tuschl T, Lai EC. A Drosophila pasha mutant distinguishes the canonical microRNA and mirtron pathways. Molecular and Cellular Biology. 29: 861-70. PMID 19047376 DOI: 10.1128/MCB.01524-08  1
2008 Flynt AS, Lai EC. Biological principles of microRNA-mediated regulation: shared themes amid diversity. Nature Reviews. Genetics. 9: 831-42. PMID 18852696 DOI: 10.1038/nrg2455  1
2008 Okamura K, Balla S, Martin R, Liu N, Lai EC. Two distinct mechanisms generate endogenous siRNAs from bidirectional transcription in Drosophila melanogaster. Nature Structural & Molecular Biology. 15: 998. PMID 18769470 DOI: 10.1038/nsmb0908-998c  1
2008 Okamura K, Chung WJ, Lai EC. The long and short of inverted repeat genes in animals: microRNAs, mirtrons and hairpin RNAs. Cell Cycle (Georgetown, Tex.). 7: 2840-5. PMID 18769156  1
2008 Okamura K, Lai EC. Endogenous small interfering RNAs in animals. Nature Reviews. Molecular Cell Biology. 9: 673-8. PMID 18719707 DOI: 10.1038/nrm2479  1
2008 Smibert P, Lai EC. Lessons from microRNA mutants in worms, flies and mice. Cell Cycle (Georgetown, Tex.). 7: 2500-8. PMID 18719388  1
2008 Liu N, Okamura K, Tyler DM, Phillips MD, Chung WJ, Lai EC. The evolution and functional diversification of animal microRNA genes. Cell Research. 18: 985-96. PMID 18711447 DOI: 10.1038/cr.2008.278  1
2008 Hagen JW, Lai EC. MicroRNA control of cell-cell signaling during development and disease Cell Cycle. 7: 2327-2332. PMID 18677099  1
2008 Chung WJ, Okamura K, Martin R, Lai EC. Endogenous RNA interference provides a somatic defense against Drosophila transposons. Current Biology : Cb. 18: 795-802. PMID 18501606 DOI: 10.1016/j.cub.2008.05.006  1
2008 Okamura K, Balla S, Martin R, Liu N, Lai EC. Two distinct mechanisms generate endogenous siRNAs from bidirectional transcription in Drosophila melanogaster. Nature Structural & Molecular Biology. 15: 581-90. PMID 18500351 DOI: 10.1038/nsmb.1438  1
2008 Okamura K, Chung WJ, Ruby JG, Guo H, Bartel DP, Lai EC. The Drosophila hairpin RNA pathway generates endogenous short interfering RNAs. Nature. 453: 803-6. PMID 18463630 DOI: 10.1038/nature07015  1
2008 Okamura K, Phillips MD, Tyler DM, Duan H, Chou YT, Lai EC. The regulatory activity of microRNA* species has substantial influence on microRNA and 3' UTR evolution. Nature Structural & Molecular Biology. 15: 354-63. PMID 18376413 DOI: 10.1038/nsmb.1409  1
2008 Cayirlioglu P, Kadow IG, Zhan X, Okamura K, Suh GS, Gunning D, Lai EC, Zipursky SL. Hybrid neurons in a microRNA mutant are putative evolutionary intermediates in insect CO2 sensory systems. Science (New York, N.Y.). 319: 1256-60. PMID 18309086 DOI: 10.1126/science.1149483  1
2008 Tyler DM, Okamura K, Chung WJ, Hagen JW, Berezikov E, Hannon GJ, Lai EC. Functionally distinct regulatory RNAs generated by bidirectional transcription and processing of microRNA loci. Genes & Development. 22: 26-36. PMID 18172163 DOI: 10.1101/gad.1615208  1
2007 Chou YT, Tam B, Linay F, Lai EC. Transgenic inhibitors of RNA interference in Drosophila. Fly. 1: 311-6. PMID 18820441  1
2007 Stark A, Lin MF, Kheradpour P, Pedersen JS, Parts L, Carlson JW, Crosby MA, Rasmussen MD, Roy S, Deoras AN, Ruby JG, Brennecke J, Hodges E, ... ... Lai EC, et al. Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures. Nature. 450: 219-32. PMID 17994088 DOI: 10.1038/nature06340  1
2007 Ruby JG, Stark A, Johnston WK, Kellis M, Bartel DP, Lai EC. Evolution, biogenesis, expression, and target predictions of a substantially expanded set of Drosophila microRNAs. Genome Research. 17: 1850-64. PMID 17989254 DOI: 10.1101/gr.6597907  1
2007 Silver SJ, Hagen JW, Okamura K, Perrimon N, Lai EC. Functional screening identifies miR-315 as a potent activator of Wingless signaling. Proceedings of the National Academy of Sciences of the United States of America. 104: 18151-6. PMID 17989227 DOI: 10.1073/pnas.0706673104  1
2007 Berezikov E, Chung WJ, Willis J, Cuppen E, Lai EC. Mammalian Mirtron Genes Molecular Cell. 28: 328-336. PMID 17964270 DOI: 10.1016/j.molcel.2007.09.028  1
2007 Okamura K, Hagen JW, Duan H, Tyler DM, Lai EC. The mirtron pathway generates microRNA-class regulatory RNAs in Drosophila. Cell. 130: 89-100. PMID 17599402 DOI: 10.1016/j.cell.2007.06.028  1
2005 Ronshaugen M, Biemar F, Piel J, Levine M, Lai EC. The Drosophila microRNA iab-4 causes a dominant homeotic transformation of halteres to wings. Genes & Development. 19: 2947-52. PMID 16357215 DOI: 10.1101/gad.1372505  1
2005 Aboobaker AA, Tomancak P, Patel N, Rubin GM, Lai EC. Drosophila microRNAs exhibit diverse spatial expression patterns during embryonic development. Proceedings of the National Academy of Sciences of the United States of America. 102: 18017-22. PMID 16330759 DOI: 10.1073/pnas.0508823102  1
2005 Lai EC. miRNAs: Whys and wherefores of miRNA-mediated regulation Current Biology. 15: R458-R460. PMID 15964265 DOI: 10.1016/j.cub.2005.06.015  1
2005 Lai EC, Tam B, Rubin GM. Pervasive regulation of Drosophila Notch target genes by GY-box-, Brd-box-, and K-box-class microRNAs. Genes & Development. 19: 1067-80. PMID 15833912 DOI: 10.1101/gad.1291905  1
2005 Lau NC, Lai EC. Diverse roles for RNA in gene regulation Genome Biology. 6. PMID 15833133 DOI: 10.1186/gb-2005-6-4-315  1
2005 Lai EC, Roegiers F, Qin X, Jan YN, Rubin GM. The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta. Development (Cambridge, England). 132: 2319-32. PMID 15829515 DOI: 10.1242/dev.01825  1
2005 Hu H, Li M, Labrador JP, McEwen J, Lai EC, Goodman CS, Bashaw GJ. Cross GTPase-activating protein (CrossGAP)/Vilse links the Roundabout receptor to Rac to regulate midline repulsion. Proceedings of the National Academy of Sciences of the United States of America. 102: 4613-8. PMID 15755809 DOI: 10.1073/pnas.0409325102  1
2004 Lai EC. Predicting and validating microRNA targets Genome Biology. 5. PMID 15345038 DOI: 10.1186/gb-2004-5-9-115  1
2004 Lai EC, Wiel C, Rubin GM. Complementary miRNA pairs suggest a regulatory role for miRNA:miRNA duplexes. Rna (New York, N.Y.). 10: 171-5. PMID 14730015 DOI: 10.1261/rna.5191904  1
2003 Lai EC, Tomancak P, Williams RW, Rubin GM. Computational identification of Drosophila microRNA genes. Genome Biology. 4: R42. PMID 12844358 DOI: 10.1186/gb-2003-4-7-r42  1
2001 Lai EC, Deblandre GA, Kintner C, Rubin GM. Drosophila neuralized is a ubiquitin ligase that promotes the internalization and degradation of delta. Developmental Cell. 1: 783-94. PMID 11740940 DOI: 10.1016/S1534-5807(01)00092-2  1
2001 Lai EC, Rubin GM. Neuralized is essential for a subset of Notch pathway-dependent cell fate decisions during Drosophila eye development. Proceedings of the National Academy of Sciences of the United States of America. 98: 5637-42. PMID 11344304 DOI: 10.1073/pnas.101135498  1
2001 Lai EC, Rubin GM. neuralized functions cell-autonomously to regulate a subset of notch-dependent processes during adult Drosophila development. Developmental Biology. 231: 217-33. PMID 11180964 DOI: 10.1006/dbio.2000.0124  1
2000 Lai EC, Bodner R, Posakony JW. The enhancer of split complex of Drosophila includes four Notch-regulated members of the bearded gene family. Development (Cambridge, England). 127: 3441-55. PMID 10903170  1
2000 Lai EC, Bodner R, Kavaler J, Freschi G, Posakony JW. Antagonism of notch signaling activity by members of a novel protein family encoded by the bearded and enhancer of split gene complexes. Development (Cambridge, England). 127: 291-306. PMID 10603347  1
1999 Nellesen DT, Lai EC, Posakony JW. Discrete enhancer elements mediate selective responsiveness of enhancer of split complex genes to common transcriptional activators. Developmental Biology. 213: 33-53. PMID 10452845 DOI: 10.1006/dbio.1999.9324  1
1998 Lai EC, Burks C, Posakony JW. The K box, a conserved 3' UTR sequence motif, negatively regulates accumulation of enhancer of split complex transcripts. Development (Cambridge, England). 125: 4077-88. PMID 9735368  1
1998 Lai EC, Posakony JW. Regulation of Drosophila neurogenesis by RNA:RNA duplexes? Cell. 93: 1103-4. PMID 9657143 DOI: 10.1016/S0092-8674(00)81454-3  1
1997 Lai EC, Posakony JW. The Bearded box, a novel 3' UTR sequence motif, mediates negative post-transcriptional regulation of Bearded and Enhancer of split Complex gene expression. Development (Cambridge, England). 124: 4847-56. PMID 9428421  1
1997 Leviten MW, Lai EC, Posakony JW. The Drosophila gene Bearded encodes a novel small protein and shares 3' UTR sequence motifs with multiple Enhancer of split complex genes. Development (Cambridge, England). 124: 4039-51. PMID 9374401  1
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