Juan Botas - Publications

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55 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Langfelder P, Cantle JP, Chatzopoulou D, Wang N, Gao F, Al-Ramahi I, Lu XH, Ramos EM, El-Zein K, Zhao Y, Deverasetty S, Tebbe A, Schaab C, Lavery DJ, Howland D, ... ... Botas J, et al. Integrated genomics and proteomics define huntingtin CAG length-dependent networks in mice. Nature Neuroscience. PMID 26900923 DOI: 10.1038/nn.4256  0.84
2015 El-Daher MT, Hangen E, Bruyère J, Poizat G, Al-Ramahi I, Pardo R, Bourg N, Souquere S, Mayet C, Pierron G, Lévêque-Fort S, Botas J, Humbert S, Saudou F. Huntingtin proteolysis releases non-polyQ fragments that cause toxicity through dynamin 1 dysregulation. The Embo Journal. 34: 2255-71. PMID 26165689 DOI: 10.15252/embj.201490808  0.84
2015 Calap-Quintana P, Soriano S, Llorens JV, Al-Ramahi I, Botas J, Moltó MD, Martínez-Sebastián MJ. TORC1 Inhibition by Rapamycin Promotes Antioxidant Defences in a Drosophila Model of Friedreich's Ataxia. Plos One. 10: e0132376. PMID 26158631 DOI: 10.1371/journal.pone.0132376  0.84
2015 Yao Y, Cui X, Al-Ramahi I, Sun X, Li B, Hou J, Difiglia M, Palacino J, Wu ZY, Ma L, Botas J, Lu B. A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity. Elife. 4. PMID 25738228 DOI: 10.7554/eLife.05449  0.84
2014 Lu XH, Mattis VB, Wang N, Al-Ramahi I, van den Berg N, Fratantoni SA, Waldvogel H, Greiner E, Osmand A, Elzein K, Xiao J, Dijkstra S, de Pril R, Vinters HV, Faull R, ... ... Botas J, et al. Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease. Science Translational Medicine. 6: 268ra178. PMID 25540325 DOI: 10.1126/scitranslmed.3010523  0.84
2013 Park J, Al-Ramahi I, Tan Q, Mollema N, Diaz-Garcia JR, Gallego-Flores T, Lu HC, Lagalwar S, Duvick L, Kang H, Lee Y, Jafar-Nejad P, Sayegh LS, Richman R, Liu X, ... ... Botas J, et al. RAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1. Nature. 498: 325-31. PMID 23719381 DOI: 10.1038/nature12204  0.84
2013 de Haro M, Al-Ramahi I, Jones KR, Holth JK, Timchenko LT, Botas J. Smaug/SAMD4A restores translational activity of CUGBP1 and suppresses CUG-induced myopathy. Plos Genetics. 9: e1003445. PMID 23637619 DOI: 10.1371/journal.pgen.1003445  0.84
2013 Lu B, Al-Ramahi I, Valencia A, Wang Q, Berenshteyn F, Yang H, Gallego-Flores T, Ichcho S, Lacoste A, Hild M, Difiglia M, Botas J, Palacino J. Identification of NUB1 as a suppressor of mutant Huntington toxicity via enhanced protein clearance. Nature Neuroscience. 16: 562-70. PMID 23525043 DOI: 10.1038/nn.3367  0.84
2013 Holth JK, Bomben VC, Reed JG, Inoue T, Younkin L, Younkin SG, Pautler RG, Botas J, Noebels JL. Tau loss attenuates neuronal network hyperexcitability in mouse and Drosophila genetic models of epilepsy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 1651-9. PMID 23345237 DOI: 10.1523/JNEUROSCI.3191-12.2013  0.84
2012 Miller JP, Yates BE, Al-Ramahi I, Berman AE, Sanhueza M, Kim E, de Haro M, DeGiacomo F, Torcassi C, Holcomb J, Gafni J, Mooney SD, Botas J, Ellerby LM, Hughes RE. A genome-scale RNA-interference screen identifies RRAS signaling as a pathologic feature of Huntington's disease. Plos Genetics. 8: e1003042. PMID 23209424 DOI: 10.1371/journal.pgen.1003042  0.84
2012 Shirasaki DI, Greiner ER, Al-Ramahi I, Gray M, Boontheung P, Geschwind DH, Botas J, Coppola G, Horvath S, Loo JA, Yang XW. Network organization of the huntingtin proteomic interactome in mammalian brain. Neuron. 75: 41-57. PMID 22794259 DOI: 10.1016/j.neuron.2012.05.024  0.84
2012 Zhang N, Li B, Al-Ramahi I, Cong X, Held JM, Kim E, Botas J, Gibson BW, Ellerby LM. Inhibition of lipid signaling enzyme diacylglycerol kinase epsilon attenuates mutant huntingtin toxicity. The Journal of Biological Chemistry. 287: 21204-13. PMID 22511757 DOI: 10.1074/jbc.M111.321661  0.84
2010 Miller JP, Holcomb J, Al-Ramahi I, de Haro M, Gafni J, Zhang N, Kim E, Sanhueza M, Torcassi C, Kwak S, Botas J, Hughes RE, Ellerby LM. Matrix metalloproteinases are modifiers of huntingtin proteolysis and toxicity in Huntington's disease. Neuron. 67: 199-212. PMID 20670829 DOI: 10.1016/j.neuron.2010.06.021  0.84
2008 Sofola O, Sundram V, Ng F, Kleyner Y, Morales J, Botas J, Jackson FR, Nelson DL. The Drosophila FMRP and LARK RNA-binding proteins function together to regulate eye development and circadian behavior. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 10200-5. PMID 18842880 DOI: 10.1523/JNEUROSCI.2786-08.2008  0.84
2008 Cukier HN, Perez AM, Collins AL, Zhou Z, Zoghbi HY, Botas J. Genetic modifiers of MeCP2 function in Drosophila. Plos Genetics. 4: e1000179. PMID 18773074 DOI: 10.1371/journal.pgen.1000179  0.84
2008 Romero E, Cha GH, Verstreken P, Ly CV, Hughes RE, Bellen HJ, Botas J. Suppression of neurodegeneration and increased neurotransmission caused by expanded full-length huntingtin accumulating in the cytoplasm. Neuron. 57: 27-40. PMID 18184562 DOI: 10.1016/j.neuron.2007.11.025  0.84
2008 Branco J, Al-Ramahi I, Ukani L, Pérez AM, Fernandez-Funez P, Rincón-Limas D, Botas J. Comparative analysis of genetic modifiers in Drosophila points to common and distinct mechanisms of pathogenesis among polyglutamine diseases. Human Molecular Genetics. 17: 376-90. PMID 17984172 DOI: 10.1093/hmg/ddm315  0.84
2007 Al-Ramahi I, Pérez AM, Lim J, Zhang M, Sorensen R, de Haro M, Branco J, Pulst SM, Zoghbi HY, Botas J. dAtaxin-2 mediates expanded Ataxin-1-induced neurodegeneration in a Drosophila model of SCA1. Plos Genetics. 3: e234. PMID 18166084 DOI: 10.1371/journal.pgen.0030234  0.84
2007 Sofola OA, Jin P, Qin Y, Duan R, Liu H, de Haro M, Nelson DL, Botas J. RNA-binding proteins hnRNP A2/B1 and CUGBP1 suppress fragile X CGG premutation repeat-induced neurodegeneration in a Drosophila model of FXTAS. Neuron. 55: 565-71. PMID 17698010 DOI: 10.1016/j.neuron.2007.07.021  0.84
2007 Sofola OA, Jin P, Botas J, Nelson DL. Argonaute-2-dependent rescue of a Drosophila model of FXTAS by FRAXE premutation repeat. Human Molecular Genetics. 16: 2326-32. PMID 17635840 DOI: 10.1093/hmg/ddm186  0.84
2007 Kaltenbach LS, Romero E, Becklin RR, Chettier R, Bell R, Phansalkar A, Strand A, Torcassi C, Savage J, Hurlburt A, Cha GH, Ukani L, Chepanoske CL, Zhen Y, Sahasrabudhe S, ... ... Botas J, et al. Huntingtin interacting proteins are genetic modifiers of neurodegeneration. Plos Genetics. 3: e82. PMID 17500595 DOI: 10.1371/journal.pgen.0030082  0.84
2007 Botas J. Drosophila researchers focus on human disease. Nature Genetics. 39: 589-91. PMID 17460691 DOI: 10.1038/ng0507-589  0.84
2007 Qi ML, Tagawa K, Enokido Y, Yoshimura N, Wada Y, Watase K, Ishiura S, Kanazawa I, Botas J, Saitoe M, Wanker EE, Okazawa H. Proteome analysis of soluble nuclear proteins reveals that HMGB1/2 suppress genotoxic stress in polyglutamine diseases. Nature Cell Biology. 9: 402-14. PMID 17384639 DOI: 10.1038/ncb1553  0.84
2006 Lam YC, Bowman AB, Jafar-Nejad P, Lim J, Richman R, Fryer JD, Hyun ED, Duvick LA, Orr HT, Botas J, Zoghbi HY. ATAXIN-1 interacts with the repressor Capicua in its native complex to cause SCA1 neuropathology. Cell. 127: 1335-47. PMID 17190598 DOI: 10.1016/j.cell.2006.11.038  0.84
2006 Kadener S, Villella A, Kula E, Palm K, Pyza E, Botas J, Hall JC, Rosbash M. Neurotoxic protein expression reveals connections between the circadian clock and mating behavior in Drosophila. Proceedings of the National Academy of Sciences of the United States of America. 103: 13537-42. PMID 16938865 DOI: 10.1073/pnas.0605962103  0.84
2006 Al-Ramahi I, Lam YC, Chen HK, de Gouyon B, Zhang M, Pérez AM, Branco J, de Haro M, Patterson C, Zoghbi HY, Botas J. CHIP protects from the neurotoxicity of expanded and wild-type ataxin-1 and promotes their ubiquitination and degradation. The Journal of Biological Chemistry. 281: 26714-24. PMID 16831871 DOI: 10.1074/jbc.M601603200  0.84
2006 de Haro M, Al-Ramahi I, De Gouyon B, Ukani L, Rosa A, Faustino NA, Ashizawa T, Cooper TA, Botas J. MBNL1 and CUGBP1 modify expanded CUG-induced toxicity in a Drosophila model of myotonic dystrophy type 1. Human Molecular Genetics. 15: 2138-45. PMID 16723374 DOI: 10.1093/hmg/ddl137  0.84
2005 Tsuda H, Jafar-Nejad H, Patel AJ, Sun Y, Chen HK, Rose MF, Venken KJ, Botas J, Orr HT, Bellen HJ, Zoghbi HY. The AXH domain of Ataxin-1 mediates neurodegeneration through its interaction with Gfi-1/Senseless proteins. Cell. 122: 633-44. PMID 16122429 DOI: 10.1016/j.cell.2005.06.012  0.84
2003 Chen HK, Fernandez-Funez P, Acevedo SF, Lam YC, Kaytor MD, Fernandez MH, Aitken A, Skoulakis EM, Orr HT, Botas J, Zoghbi HY. Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1. Cell. 113: 457-68. PMID 12757707 DOI: 10.1016/S0092-8674(03)00349-0  0.84
2002 Bergman CM, Pfeiffer BD, Rincón-Limas DE, Hoskins RA, Gnirke A, Mungall CJ, Wang AM, Kronmiller B, Pacleb J, Park S, Stapleton M, Wan K, George RA, de Jong PJ, Botas J, et al. Assessing the impact of comparative genomic sequence data on the functional annotation of the Drosophila genome. Genome Biology. 3: RESEARCH0086. PMID 12537575  0.84
2002 Zoghbi HY, Botas J. Mouse and fly models of neurodegeneration. Trends in Genetics : Tig. 18: 463-71. PMID 12175807 DOI: 10.1016/S0168-9525(02)02729-4  0.84
2001 Capovilla M, Kambris Z, Botas J. Direct regulation of the muscle-identity gene apterous by a Hox protein in the somatic mesoderm. Development (Cambridge, England). 128: 1221-30. PMID 11262224  0.84
2000 Lu CH, Rincón-Limas DE, Botas J. Conserved overlapping and reciprocal expression of msh/Msx1 and apterous/Lhx2 in Drosophila and mice. Mechanisms of Development. 99: 177-81. PMID 11091089 DOI: 10.1016/S0925-4773(00)00479-2  0.84
2000 Fernandez-Funez P, Nino-Rosales ML, de Gouyon B, She WC, Luchak JM, Martinez P, Turiegano E, Benito J, Capovilla M, Skinner PJ, McCall A, Canal I, Orr HT, Zoghbi HY, Botas J. Identification of genes that modify ataxin-1-induced neurodegeneration. Nature. 408: 101-6. PMID 11081516 DOI: 10.1038/35040584  0.84
2000 Rincón-Limas DE, Lu CH, Canal I, Botas J. The level of DLDB/CHIP controls the activity of the LIM homeodomain protein apterous: evidence for a functional tetramer complex in vivo. The Embo Journal. 19: 2602-14. PMID 10835358 DOI: 10.1093/emboj/19.11.2602  0.84
1999 Lilly B, O'Keefe DD, Thomas JB, Botas J. The LIM homeodomain protein dLim1 defines a subclass of neurons within the embryonic ventral nerve cord of Drosophila. Mechanisms of Development. 88: 195-205. PMID 10534618 DOI: 10.1016/S0925-4773(99)00189-6  0.84
1999 Rincón-Limas DE, Lu CH, Canal I, Calleja M, Rodríguez-Esteban C, Izpisúa-Belmonte JC, Botas J. Conservation of the expression and function of apterous orthologs in Drosophila and mammals. Proceedings of the National Academy of Sciences of the United States of America. 96: 2165-70. PMID 10051612 DOI: 10.1073/pnas.96.5.2165  0.84
1998 Fernández-Fúnez P, Lu CH, Rincón-Limas DE, García-Bellido A, Botas J. The relative expression amounts of apterous and its co-factor dLdb/Chip are critical for dorso-ventral compartmentalization in the Drosophila wing. The Embo Journal. 17: 6846-53. PMID 9843490 DOI: 10.1093/emboj/17.23.6846  0.84
1998 Capovilla M, Botas J. Functional dominance among Hox genes: repression dominates activation in the regulation of Dpp. Development (Cambridge, England). 125: 4949-57. PMID 9811579  0.84
1998 Rodriguez-Esteban C, Schwabe JW, Peña JD, Rincon-Limas DE, Magallón J, Botas J, Izpisúa Belmonte JC. Lhx2, a vertebrate homologue of apterous, regulates vertebrate limb outgrowth. Development (Cambridge, England). 125: 3925-34. PMID 9735354  0.84
1998 Bendall AJ, Rincón-Limas DE, Botas J, Abate-Shen C. Protein complex formation between Msx1 and Lhx2 homeoproteins is incompatible with DNA binding activity. Differentiation; Research in Biological Diversity. 63: 151-7. PMID 9697309 DOI: 10.1046/j.1432-0436.1998.6330151.x  0.84
1997 Stanley H, Botas J, Malhotra V. The mechanism of Golgi segregation during mitosis is cell type-specific. Proceedings of the National Academy of Sciences of the United States of America. 94: 14467-70. PMID 9405636 DOI: 10.1073/pnas.94.26.14467  0.84
1996 Botas J, Auwers L. Chromosomal binding sites of Ultrabithorax homeotic proteins. Mechanisms of Development. 56: 129-38. PMID 8798153 DOI: 10.1016/0925-4773(96)00519-9  0.84
1994 Chan SK, Jaffe L, Capovilla M, Botas J, Mann RS. The DNA binding specificity of Ultrabithorax is modulated by cooperative interactions with extradenticle, another homeoprotein. Cell. 78: 603-15. PMID 7915199 DOI: 10.1016/0092-8674(94)90525-8  0.84
1994 Capovilla M, Brandt M, Botas J. Direct regulation of decapentaplegic by Ultrabithorax and its role in Drosophila midgut morphogenesis. Cell. 76: 461-75. PMID 7906203 DOI: 10.1016/0092-8674(94)90111-2  0.84
1994 Eldon E, Kooyer S, D'Evelyn D, Duman M, Lawinger P, Botas J, Bellen H. The Drosophila 18 wheeler is required for morphogenesis and has striking similarities to Toll. Development (Cambridge, England). 120: 885-99. PMID 7600965  0.84
1993 Botas J. Control of morphogenesis and differentiation by HOM/Hox genes. Current Opinion in Cell Biology. 5: 1015-22. PMID 7907490  0.84
1993 Irvine KD, Botas J, Jha S, Mann RS, Hogness DS. Negative autoregulation by Ultrabithorax controls the level and pattern of its expression. Development (Cambridge, England). 117: 387-99. PMID 7900988  0.84
1992 Vachon G, Cohen B, Pfeifle C, McGuffin ME, Botas J, Cohen SM. Homeotic genes of the Bithorax complex repress limb development in the abdomen of the Drosophila embryo through the target gene Distal-less. Cell. 71: 437-50. PMID 1358457 DOI: 10.1016/0092-8674(92)90513-C  0.84
1988 Botas J, Cabrera CV, Garcia-Bellido A. The reinforcement-extinction process of selector gene activity: a positive feed-back loop and cell-cell interactions in Ultrabithorax patterning Roux's Archives of Developmental Biology. 197: 424-434. DOI: 10.1007/BF00398994  0.84
1986 Capdevila MP, Botas J, García-Bellido A. Genetic interactions between the Polycomb locus and the Antennapedia and Bithorax complexes of Drosophila Roux's Archives of Developmental Biology. 195: 417-432. DOI: 10.1007/BF00375746  0.84
1985 Cabrera CV, Botas J, Garcia-Bellido A. Distribution of Ultrabithorax proteins in mutants of Drosophila bithorax complex and its transregulatory genes Nature. 318: 569-571.  0.84
1983 Morata G, Botas J, Kerridge S, Struhl G. Homeotic transformations of the abdominal segments of Drosophila caused by breaking or deleting a central portion of the bithorax complex. Journal of Embryology and Experimental Morphology. 78: 319-41. PMID 6420494  0.84
1983 García-Bellido A, del Prado JM, Botas J. The effect of aneuploidy on embryonic development in Drosophila melanogaster Mgg Molecular & General Genetics. 192: 253-263. DOI: 10.1007/BF00327675  0.84
1982 Botas J, Moscoso del Prado J, García-Bellido A. Gene-dose titration analysis in the search of trans-regulatory genes in Drosophila. The Embo Journal. 1: 307-10. PMID 7188185  0.84
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