Bruno Lemaitre - Publications

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155 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Hanson MA, Lemaitre B. Antimicrobial peptides do not directly contribute to aging in Drosophila, but improve lifespan by preventing dysbiosis. Disease Models & Mechanisms. 16. PMID 36847474 DOI: 10.1242/dmm.049965  0.553
2022 Yao Z, Cai Z, Ma Q, Bai S, Wang Y, Zhang P, Guo Q, Gu J, Lemaitre B, Zhang H. Compartmentalized PGRP expression along the dipteran Bactrocera dorsalis gut forms a zone of protection for symbiotic bacteria. Cell Reports. 41: 111523. PMID 36260997 DOI: 10.1016/j.celrep.2022.111523  0.389
2022 Hanson MA, Lemaitre B. Repeated truncation of a modular antimicrobial peptide gene for neural context. Plos Genetics. 18: e1010259. PMID 35714143 DOI: 10.1371/journal.pgen.1010259  0.598
2021 Carboni AL, Hanson MA, Lindsay SA, Wasserman SA, Lemaitre B. Cecropins contribute to Drosophila host defense against a subset of fungal and Gram-negative bacterial infection. Genetics. PMID 34791204 DOI: 10.1093/genetics/iyab188  0.658
2021 Hanson MA, Cohen LB, Marra A, Iatsenko I, Wasserman SA, Lemaitre B. The Drosophila Baramicin polypeptide gene protects against fungal infection. Plos Pathogens. 17: e1009846. PMID 34432851 DOI: 10.1371/journal.ppat.1009846  0.643
2021 Masson F, Rommelaere S, Marra A, Schüpfer F, Lemaitre B. Dual proteomics of Drosophila melanogaster hemolymph infected with the heritable endosymbiont Spiroplasma poulsonii. Plos One. 16: e0250524. PMID 33914801 DOI: 10.1371/journal.pone.0250524  0.377
2020 Ramond E, Dudzic JP, Lemaitre B. Comparative RNA-Seq analyses of Drosophila plasmatocytes reveal gene specific signatures in response to clean injury and septic injury. Plos One. 15: e0235294. PMID 32598400 DOI: 10.1371/journal.pone.0235294  0.442
2020 Masson F, Schüpfer F, Jollivet C, Lemaitre B. Transformation of the sex-manipulative endosymbiont and persisting hurdles for functional genetics studies. Applied and Environmental Microbiology. PMID 32444468 DOI: 10.1128/AEM.00835-20  0.395
2020 Iatsenko I, Marra A, Boquete JP, Peña J, Lemaitre B. Iron sequestration by transferrin 1 mediates nutritional immunity in . Proceedings of the National Academy of Sciences of the United States of America. PMID 32188787 DOI: 10.1073/Pnas.1914830117  0.406
2020 Li X, Rommelaere S, Kondo S, Lemaitre B. Renal Purge of Hemolymphatic Lipids Prevents the Accumulation of ROS-Induced Inflammatory Oxidized Lipids and Protects Drosophila from Tissue Damage. Immunity. 52: 374-387.e6. PMID 32075729 DOI: 10.1016/j.immuni.2020.01.008  0.389
2020 Ramond E, Petrignani B, Dudzic JP, Boquete JP, Poidevin M, Kondo S, Lemaitre B. The adipokine NimrodB5 regulates peripheral hematopoiesis in Drosophila. The Febs Journal. PMID 32009293 DOI: 10.1111/febs.15237  0.439
2019 Hanson MA, Lemaitre B. New insights on Drosophila antimicrobial peptide function in host defense and beyond. Current Opinion in Immunology. 62: 22-30. PMID 31835066 DOI: 10.1016/J.Coi.2019.11.008  0.622
2019 Hanson MA, Lemaitre B, Unckless RL. Dynamic Evolution of Antimicrobial Peptides Underscores Trade-Offs Between Immunity and Ecological Fitness. Frontiers in Immunology. 10: 2620. PMID 31781114 DOI: 10.3389/Fimmu.2019.02620  0.659
2019 Sanchez Bosch P, Makhijani K, Herboso L, Gold KS, Baginsky R, Woodcock KJ, Alexander B, Kukar K, Corcoran S, Jacobs T, Ouyang D, Wong C, Ramond EJV, Rhiner C, Moreno E, ... Lemaitre B, et al. Adult Drosophila Lack Hematopoiesis but Rely on a Blood Cell Reservoir at the Respiratory Epithelia to Relay Infection Signals to Surrounding Tissues. Developmental Cell. PMID 31735669 DOI: 10.1016/J.Devcel.2019.10.017  0.507
2019 Parvy JP, Yu Y, Dostalova A, Kondo S, Kurjan A, Bulet P, Lemaître B, Vidal M, Cordero JB. The antimicrobial peptide defensin cooperates with tumour necrosis factor to drive tumour cell death in . Elife. 8. PMID 31358113 DOI: 10.7554/Elife.45061  0.355
2019 Hanson MA, Dostálová A, Ceroni C, Poidevin M, Kondo S, Lemaître B. Correction: Synergy and remarkable specificity of antimicrobial peptides in vivo using a systematic knockout approach. Elife. 8. PMID 31135338 DOI: 10.7554/eLife.48778  0.431
2019 Dudzic JP, Hanson MA, Iatsenko I, Kondo S, Lemaitre B. More Than Black or White: Melanization and Toll Share Regulatory Serine Proteases in Drosophila. Cell Reports. 27: 1050-1061.e3. PMID 31018123 DOI: 10.1016/J.Celrep.2019.03.101  0.586
2019 Melcarne C, Ramond E, Dudzic J, Bretscher AJ, Kurucz É, Andó I, Lemaitre B. Two Nimrod receptors, NimC1 and Eater, synergistically contribute to bacterial phagocytosis in Drosophila melanogaster. The Febs Journal. PMID 30993828 DOI: 10.1111/febs.14857  0.41
2019 Melcarne C, Lemaitre B, Kurant E. Phagocytosis in Drosophila: From molecules and cellular machinery to physiology. Insect Biochemistry and Molecular Biology. 109: 1-12. PMID 30953686 DOI: 10.1016/j.ibmb.2019.04.002  0.36
2019 Hanson MA, Dostálová A, Ceroni C, Poidevin M, Kondo S, Lemaître B. Synergy and remarkable specificity of antimicrobial peptides using a systematic knockout approach. Elife. 8. PMID 30803481 DOI: 10.7554/Elife.44341  0.651
2019 Garcia-Arraez MG, Masson F, Escobar JCP, Lemaitre B. Functional analysis of RIP toxins from the Drosophila endosymbiont Spiroplasma poulsonii. Bmc Microbiology. 19: 46. PMID 30786854 DOI: 10.1186/s12866-019-1410-1  0.423
2019 Lemaître B. Decision letter: Host-pathogen coevolution increases genetic variation in susceptibility to infection Elife. DOI: 10.7554/Elife.46440.021  0.377
2019 Parvy J, Yu Y, Dostalova A, Kondo S, Kurjan A, Bulet P, Lemaître B, Vidal M, Cordero JB. Author response: The antimicrobial peptide defensin cooperates with tumour necrosis factor to drive tumour cell death in Drosophila Elife. DOI: 10.7554/Elife.45061.019  0.337
2018 Fabian DK, Garschall K, Klepsatel P, Santos-Matos G, Sucena É, Kapun M, Lemaitre B, Schlötterer C, Arking R, Flatt T. Evolution of longevity improves immunity in . Evolution Letters. 2: 567-579. PMID 30564440 DOI: 10.1002/evl3.89  0.405
2018 Iatsenko I, Boquete JP, Lemaitre B. Microbiota-Derived Lactate Activates Production of Reactive Oxygen Species by the Intestinal NADPH Oxidase Nox and Shortens Drosophila Lifespan. Immunity. 49: 929-942.e5. PMID 30446385 DOI: 10.1016/j.immuni.2018.09.017  0.446
2018 Miguel-Aliaga I, Jasper H, Lemaitre B. Anatomy and Physiology of the Digestive Tract of . Genetics. 210: 357-396. PMID 30287514 DOI: 10.1534/Genetics.118.300224  0.432
2018 Zhai Z, Boquete JP, Lemaitre B. Cell-Specific Imd-NF-κB Responses Enable Simultaneous Antibacterial Immunity and Intestinal Epithelial Cell Shedding upon Bacterial Infection. Immunity. 48: 897-910.e7. PMID 29752064 DOI: 10.1016/J.Immuni.2018.04.010  0.848
2018 Harumoto T, Lemaitre B. Male-killing toxin in a bacterial symbiont of Drosophila. Nature. PMID 29720654 DOI: 10.1038/s41586-018-0086-2  0.362
2018 Harumoto T, Fukatsu T, Lemaitre B. Common and unique strategies of male killing evolved in two distinctsymbionts. Proceedings. Biological Sciences. 285. PMID 29563258 DOI: 10.1098/rspb.2017.2167  0.31
2018 Masson F, Calderon Copete S, Schüpfer F, Garcia-Arraez G, Lemaitre B. Culture of the Insect EndosymbiontHighlights Bacterial Genes Involved in Host-Symbiont Interaction. Mbio. 9. PMID 29559567 DOI: 10.1128/mBio.00024-18  0.42
2017 Yanagawa A, Neyen C, Lemaitre B, Marion-Poll F. The gram-negative sensing receptor PGRP-LC contributes to grooming induction in Drosophila. Plos One. 12: e0185370. PMID 29121087 DOI: 10.1371/journal.pone.0185370  0.405
2017 Chng WA, Koch R, Li X, Kondo S, Nagoshi E, Lemaitre B. Transforming Growth Factor β/Activin signaling in neurons increases susceptibility to starvation. Plos One. 12: e0187054. PMID 29084242 DOI: 10.1371/journal.pone.0187054  0.352
2017 Dostálová A, Rommelaere S, Poidevin M, Lemaitre B. Thioester-containing proteins regulate the Toll pathway and play a role in Drosophila defence against microbial pathogens and parasitoid wasps. Bmc Biology. 15: 79. PMID 28874153 DOI: 10.1186/s12915-017-0408-0  0.522
2017 Zhai Z, Boquete JP, Lemaitre B. A genetic framework controlling the differentiation of intestinal stem cells during regeneration in Drosophila. Plos Genetics. 13: e1006854. PMID 28662029 DOI: 10.1371/Journal.Pgen.1006854  0.769
2017 Masson F, Lemaitre B. Protection from within. Elife. 6. PMID 28079522 DOI: 10.7554/eLife.24111  0.409
2016 Chng WA, Hietakangas V, Lemaitre B. Physiological Adaptations to Sugar Intake: New Paradigms from Drosophila melanogaster. Trends in Endocrinology and Metabolism: Tem. PMID 27923532 DOI: 10.1016/j.tem.2016.11.003  0.337
2016 Iatsenko I, Kondo S, Mengin-Lecreulx D, Lemaitre B. PGRP-SD, an Extracellular Pattern-Recognition Receptor, Enhances Peptidoglycan-Mediated Activation of the Drosophila Imd Pathway. Immunity. 45: 1013-1023. PMID 27851910 DOI: 10.1016/j.immuni.2016.10.029  0.448
2016 Harumoto T, Anbutsu H, Lemaitre B, Fukatsu T. Male-killing symbiont damages host's dosage-compensated sex chromosome to induce embryonic apoptosis. Nature Communications. 7: 12781. PMID 27650264 DOI: 10.1038/ncomms12781  0.365
2016 Neyen C, Runchel C, Schüpfer F, Meier P, Lemaitre B. The regulatory isoform rPGRP-LC induces immune resolution via endosomal degradation of receptors. Nature Immunology. PMID 27548432 DOI: 10.1038/Ni.3536  0.659
2016 Ramond E, Maclachlan C, Clerc-Rosset S, Knott GW, Lemaitre B. Cell Division by Longitudinal Scission in the Insect Endosymbiont Spiroplasma poulsonii. Mbio. 7. PMID 27460796 DOI: 10.1128/mBio.00881-16  0.363
2016 Paredes JC, Herren JK, Schüpfer F, Lemaitre B. The Role of Lipid Competition for Endosymbiont-Mediated Protection against Parasitoid Wasps in Drosophila. Mbio. 7. PMID 27406568 DOI: 10.1128/mBio.01006-16  0.412
2016 Espaillat A, Forsmo O, El Biari K, Björk R, Lemaitre B, Trygg J, Cañada FJ, de Pedro MA, Cava F. Chemometric Analysis of Bacterial Peptidoglycan Reveals Atypical Modifications which Empower the Cell Wall against Predatory Enzymes and Fly Innate Immunity. Journal of the American Chemical Society. PMID 27337563 DOI: 10.1021/jacs.6b04430  0.409
2016 Chakrabarti S, Dudzic JP, Li X, Collas EJ, Boquete JP, Lemaitre B. Remote Control of Intestinal Stem Cell Activity by Haemocytes in Drosophila. Plos Genetics. 12: e1006089. PMID 27231872 DOI: 10.1371/Journal.Pgen.1006089  0.838
2015 Zhai Z, Kondo S, Ha N, Boquete JP, Brunner M, Ueda R, Lemaitre B. Accumulation of differentiating intestinal stem cell progenies drives tumorigenesis. Nature Communications. 6: 10219. PMID 26690827 DOI: 10.1038/Ncomms10219  0.77
2015 Neyen C, Lemaitre B. Sensing Gram-negative bacteria: a phylogenetic perspective. Current Opinion in Immunology. 38: 8-17. PMID 26569344 DOI: 10.1016/j.coi.2015.10.007  0.433
2015 Yao Z, Wang A, Li Y, Cai Z, Lemaitre B, Zhang H. The dual oxidase gene BdDuox regulates the intestinal bacterial community homeostasis of Bactrocera dorsalis. The Isme Journal. PMID 26565723 DOI: 10.1038/ismej.2015.202  0.465
2015 Dudzic JP, Kondo S, Ueda R, Bergman CM, Lemaitre B. Drosophila innate immunity: regional and functional specialization of prophenoloxidases. Bmc Biology. 13: 81. PMID 26437768 DOI: 10.1186/s12915-015-0193-6  0.482
2015 Hamilton PT, Votýpka J, Dostálová A, Yurchenko V, Bird NH, Lukeš J, Lemaitre B, Perlman SJ. Infection Dynamics and Immune Response in a Newly Described Drosophila-Trypanosomatid Association. Mbio. 6: e01356-15. PMID 26374124 DOI: 10.1128/mBio.01356-15  0.739
2015 Vijendravarma RK, Narasimha S, Chakrabarti S, Babin A, Kolly S, Lemaitre B, Kawecki TJ. Gut physiology mediates a trade-off between adaptation to malnutrition and susceptibility to food-borne pathogens. Ecology Letters. 18: 1078-86. PMID 26249109 DOI: 10.1111/Ele.12490  0.829
2015 Bou Sleiman MS, Osman D, Massouras A, Hoffmann AA, Lemaitre B, Deplancke B. Genetic, molecular and physiological basis of variation in Drosophila gut immunocompetence. Nature Communications. 6: 7829. PMID 26213329 DOI: 10.1038/Ncomms8829  0.465
2015 Neyen C, Lemaitre B. Different flavors of Toll guide olfaction. Trends in Immunology. 36: 439-41. PMID 26150191 DOI: 10.1016/j.it.2015.06.008  0.384
2015 Paredes JC, Herren JK, Schüpfer F, Marin R, Claverol S, Kuo CH, Lemaitre B, Béven L. Genome sequence of the Drosophila melanogaster male-killing Spiroplasma strain MSRO endosymbiont. Mbio. 6. PMID 25827421 DOI: 10.1128/Mbio.02437-14  0.396
2015 Bretscher AJ, Honti V, Binggeli O, Burri O, Poidevin M, Kurucz É, Zsámboki J, Andó I, Lemaitre B. The Nimrod transmembrane receptor Eater is required for hemocyte attachment to the sessile compartment in Drosophila melanogaster. Biology Open. 4: 355-63. PMID 25681394 DOI: 10.1242/bio.201410595  0.363
2015 Neyen C, Binggeli O, Roversi P, Bertin L, Sleiman MB, Lemaitre B. The Black cells phenotype is caused by a point mutation in the Drosophila pro-phenoloxidase 1 gene that triggers melanization and hematopoietic defects. Developmental and Comparative Immunology. 50: 166-74. PMID 25543001 DOI: 10.1016/j.dci.2014.12.011  0.358
2014 Chng WB, Bou Sleiman MS, Schüpfer F, Lemaitre B. Transforming growth factor β/activin signaling functions as a sugar-sensing feedback loop to regulate digestive enzyme expression. Cell Reports. 9: 336-48. PMID 25284780 DOI: 10.1016/j.celrep.2014.08.064  0.303
2014 Chakrabarti S, Poidevin M, Lemaitre B. The Drosophila MAPK p38c regulates oxidative stress and lipid homeostasis in the intestine. Plos Genetics. 10: e1004659. PMID 25254641 DOI: 10.1371/Journal.Pgen.1004659  0.825
2014 Herren JK, Paredes JC, Schüpfer F, Arafah K, Bulet P, Lemaitre B. Insect endosymbiont proliferation is limited by lipid availability. Elife. 3: e02964. PMID 25027439 DOI: 10.7554/eLife.02964  0.327
2014 Broderick NA, Buchon N, Lemaitre B. Microbiota-induced changes in drosophila melanogaster host gene expression and gut morphology. Mbio. 5: e01117-14. PMID 24865556 DOI: 10.1128/Mbio.01117-14  0.839
2014 Binggeli O, Neyen C, Poidevin M, Lemaitre B. Prophenoloxidase activation is required for survival to microbial infections in Drosophila. Plos Pathogens. 10: e1004067. PMID 24788090 DOI: 10.1371/journal.ppat.1004067  0.499
2014 Neyen C, Bretscher AJ, Binggeli O, Lemaitre B. Methods to study Drosophila immunity. Methods (San Diego, Calif.). 68: 116-28. PMID 24631888 DOI: 10.1016/j.ymeth.2014.02.023  0.506
2013 Lemaitre B, Miguel-Aliaga I. The digestive tract of Drosophila melanogaster. Annual Review of Genetics. 47: 377-404. PMID 24016187 DOI: 10.1146/Annurev-Genet-111212-133343  0.447
2013 Gendrin M, Zaidman-Rémy A, Broderick NA, Paredes J, Poidevin M, Roussel A, Lemaitre B. Functional analysis of PGRP-LA in Drosophila immunity. Plos One. 8: e69742. PMID 23922788 DOI: 10.1371/Journal.Pone.0069742  0.82
2013 Buchon N, Broderick NA, Lemaitre B. Gut homeostasis in a microbial world: insights from Drosophila melanogaster. Nature Reviews. Microbiology. 11: 615-26. PMID 23893105 DOI: 10.1038/Nrmicro3074  0.838
2013 Lemaitre B, Girardin SE. Translation inhibition and metabolic stress pathways in the host response to bacterial pathogens. Nature Reviews. Microbiology. 11: 365-9. PMID 23669888 DOI: 10.1038/Nrmicro3029  0.543
2013 Buchon N, Osman D, David FP, Fang HY, Boquete JP, Deplancke B, Lemaitre B. Morphological and molecular characterization of adult midgut compartmentalization in Drosophila. Cell Reports. 3: 1725-38. PMID 23643535 DOI: 10.1016/J.CELREP.2013.05.019  0.701
2013 Aparicio R, Neyen C, Lemaitre B, Busturia A. dRYBP contributes to the negative regulation of the Drosophila Imd pathway. Plos One. 8: e62052. PMID 23596533 DOI: 10.1371/journal.pone.0062052  0.546
2013 Herren JK, Paredes JC, Schüpfer F, Lemaitre B. Vertical transmission of a Drosophila endosymbiont via cooption of the yolk transport and internalization machinery. Mbio. 4. PMID 23462112 DOI: 10.1128/mBio.00532-12  0.348
2012 Osman D, Buchon N, Chakrabarti S, Huang YT, Su WC, Poidevin M, Tsai YC, Lemaitre B. Autocrine and paracrine unpaired signaling regulate intestinal stem cell maintenance and division. Journal of Cell Science. 125: 5944-9. PMID 23038775 DOI: 10.1242/Jcs.113100  0.813
2012 Chakrabarti S, Liehl P, Buchon N, Lemaitre B. Infection-induced host translational blockage inhibits immune responses and epithelial renewal in the Drosophila gut. Cell Host & Microbe. 12: 60-70. PMID 22817988 DOI: 10.1016/J.Chom.2012.06.001  0.823
2012 Neyen C, Poidevin M, Roussel A, Lemaitre B. Tissue- and ligand-specific sensing of gram-negative infection in drosophila by PGRP-LC isoforms and PGRP-LE. Journal of Immunology (Baltimore, Md. : 1950). 189: 1886-97. PMID 22772451 DOI: 10.4049/jimmunol.1201022  0.527
2012 Lemaitre B, Nicolas E, Michaut L, Reichhart JM, Hoffmann JA. Pillars article: the dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell. 1996. 86: 973-983. Journal of Immunology (Baltimore, Md. : 1950). 188: 5210-20. PMID 22611248  0.691
2012 Broderick NA, Lemaitre B. Gut-associated microbes of Drosophila melanogaster. Gut Microbes. 3: 307-21. PMID 22572876 DOI: 10.4161/Gmic.19896  0.715
2012 Lemaitre B. I15 The drosophila gut: A new paradigm for epithelial immune response Cytokine. 59: 494. DOI: 10.1016/J.CYTO.2012.06.305  0.385
2011 Paredes JC, Welchman DP, Poidevin M, Lemaitre B. Negative regulation by amidase PGRPs shapes the Drosophila antibacterial response and protects the fly from innocuous infection. Immunity. 35: 770-9. PMID 22118526 DOI: 10.1016/j.immuni.2011.09.018  0.572
2011 Opota O, Vallet-Gély I, Vincentelli R, Kellenberger C, Iacovache I, Gonzalez MR, Roussel A, van der Goot FG, Lemaitre B. Monalysin, a novel ß-pore-forming toxin from the Drosophila pathogen Pseudomonas entomophila, contributes to host intestinal damage and lethality. Plos Pathogens. 7: e1002259. PMID 21980286 DOI: 10.1371/journal.ppat.1002259  0.488
2011 Kuraishi T, Binggeli O, Opota O, Buchon N, Lemaitre B. Genetic evidence for a protective role of the peritrophic matrix against intestinal bacterial infection in Drosophila melanogaster. Proceedings of the National Academy of Sciences of the United States of America. 108: 15966-71. PMID 21896728 DOI: 10.1073/Pnas.1105994108  0.763
2011 Herren JK, Lemaitre B. Spiroplasma and host immunity: activation of humoral immune responses increases endosymbiont load and susceptibility to certain Gram-negative bacterial pathogens in Drosophila melanogaster. Cellular Microbiology. 13: 1385-96. PMID 21740495 DOI: 10.1111/j.1462-5822.2011.01627.x  0.534
2011 Alattia JR, Kuraishi T, Dimitrov M, Chang I, Lemaitre B, Fraering PC. Mercury is a direct and potent γ-secretase inhibitor affecting Notch processing and development in Drosophila. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 2287-95. PMID 21415381 DOI: 10.1096/fj.10-174078  0.314
2011 Zaidman-Rémy A, Poidevin M, Hervé M, Welchman DP, Paredes JC, Fahlander C, Steiner H, Mengin-Lecreulx D, Lemaitre B. Drosophila immunity: analysis of PGRP-SB1 expression, enzymatic activity and function. Plos One. 6: e17231. PMID 21364998 DOI: 10.1371/journal.pone.0017231  0.559
2010 Buchon N, Broderick NA, Kuraishi T, Lemaitre B. Drosophila EGFR pathway coordinates stem cell proliferation and gut remodeling following infection. Bmc Biology. 8: 152. PMID 21176204 DOI: 10.1186/1741-7007-8-152  0.824
2010 Vallet-Gely I, Opota O, Boniface A, Novikov A, Lemaitre B. A secondary metabolite acting as a signalling molecule controls Pseudomonas entomophila virulence. Cellular Microbiology. 12: 1666-79. PMID 20597908 DOI: 10.1111/j.1462-5822.2010.01501.x  0.52
2010 Vallet-Gely I, Novikov A, Augusto L, Liehl P, Bolbach G, Péchy-Tarr M, Cosson P, Keel C, Caroff M, Lemaitre B. Association of hemolytic activity of Pseudomonas entomophila, a versatile soil bacterium, with cyclic lipopeptide production. Applied and Environmental Microbiology. 76: 910-21. PMID 20023108 DOI: 10.1128/Aem.02112-09  0.8
2009 Defaye A, Evans I, Crozatier M, Wood W, Lemaitre B, Leulier F. Genetic ablation of Drosophila phagocytes reveals their contribution to both development and resistance to bacterial infection. Journal of Innate Immunity. 1: 322-34. PMID 20375589 DOI: 10.1159/000210264  0.76
2009 Gendrin M, Welchman DP, Poidevin M, Hervé M, Lemaitre B. Long-range activation of systemic immunity through peptidoglycan diffusion in Drosophila. Plos Pathogens. 5: e1000694. PMID 20019799 DOI: 10.1371/Journal.Ppat.1000694  0.817
2009 Geuking P, Narasimamurthy R, Lemaitre B, Basler K, Leulier F. A non-redundant role for Drosophila Mkk4 and hemipterous/Mkk7 in TAK1-mediated activation of JNK. Plos One. 4: e7709. PMID 19888449 DOI: 10.1371/journal.pone.0007709  0.709
2009 Buchon N, Broderick NA, Chakrabarti S, Lemaitre B. Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila. Genes & Development. 23: 2333-44. PMID 19797770 DOI: 10.1101/Gad.1827009  0.832
2009 Welchman DP, Aksoy S, Jiggins F, Lemaitre B. Insect immunity: from pattern recognition to symbiont-mediated host defense. Cell Host & Microbe. 6: 107-14. PMID 19683677 DOI: 10.1016/J.Chom.2009.07.008  0.485
2009 Buchon N, Poidevin M, Kwon HM, Guillou A, Sottas V, Lee BL, Lemaitre B. A single modular serine protease integrates signals from pattern-recognition receptors upstream of the Drosophila Toll pathway. Proceedings of the National Academy of Sciences of the United States of America. 106: 12442-7. PMID 19590012 DOI: 10.1073/Pnas.0901924106  0.732
2009 Roh KB, Kim CH, Lee H, Kwon HM, Park JW, Ryu JH, Kurokawa K, Ha NC, Lee WJ, Lemaitre B, Söderhäll K, Lee BL. Proteolytic cascade for the activation of the insect toll pathway induced by the fungal cell wall component. The Journal of Biological Chemistry. 284: 19474-81. PMID 19473968 DOI: 10.1074/jbc.M109.007419  0.397
2009 Buchon N, Broderick NA, Poidevin M, Pradervand S, Lemaitre B. Drosophila intestinal response to bacterial infection: activation of host defense and stem cell proliferation. Cell Host & Microbe. 5: 200-11. PMID 19218090 DOI: 10.1016/J.Chom.2009.01.003  0.85
2009 Quevillon-Cheruel S, Leulliot N, Muniz CA, Vincent M, Gallay J, Argentini M, Cornu D, Boccard F, Lemaître B, van Tilbeurgh H. Evf, a virulence factor produced by the Drosophila pathogen Erwinia carotovora, is an S-palmitoylated protein with a new fold that binds to lipid vesicles. The Journal of Biological Chemistry. 284: 3552-62. PMID 18978353 DOI: 10.1074/Jbc.M808334200  0.377
2009 Broderick NA, Welchman DP, Lemaitre B. Recognition and response to microbial infection in Drosophila Insect Infection and Immunity: Evolution, Ecology, and Mechanisms. DOI: 10.1093/acprof:oso/9780199551354.003.0002  0.701
2008 Tang H, Kambris Z, Lemaitre B, Hashimoto C. A serpin that regulates immune melanization in the respiratory system of Drosophila. Developmental Cell. 15: 617-26. PMID 18854145 DOI: 10.1016/J.Devcel.2008.08.017  0.52
2008 Scherfer C, Tang H, Kambris Z, Lhocine N, Hashimoto C, Lemaitre B. Drosophila Serpin-28D regulates hemolymph phenoloxidase activity and adult pigmentation. Developmental Biology. 323: 189-96. PMID 18801354 DOI: 10.1016/J.Ydbio.2008.08.030  0.793
2008 Lhocine N, Ribeiro PS, Buchon N, Wepf A, Wilson R, Tenev T, Lemaitre B, Gstaiger M, Meier P, Leulier F. PIMS modulates immune tolerance by negatively regulating Drosophila innate immune signaling. Cell Host & Microbe. 4: 147-58. PMID 18692774 DOI: 10.1016/J.Chom.2008.07.004  0.857
2008 Lemaitre B, Ausubel FM. Animal models for host-pathogen interactions. Current Opinion in Microbiology. 11: 249-50. PMID 18539076 DOI: 10.1016/J.Mib.2008.05.002  0.33
2008 Romeo Y, Lemaitre B. Drosophila immunity: methods for monitoring the activity of Toll and Imd signaling pathways. Methods in Molecular Biology (Clifton, N.J.). 415: 379-94. PMID 18370166 DOI: 10.1007/978-1-59745-570-1_22  0.554
2008 Vallet-Gely I, Lemaitre B, Boccard F. Bacterial strategies to overcome insect defences. Nature Reviews. Microbiology. 6: 302-13. PMID 18327270 DOI: 10.1038/Nrmicro1870  0.51
2008 Leulier F, Lemaitre B. Toll-like receptors--taking an evolutionary approach. Nature Reviews. Genetics. 9: 165-78. PMID 18227810 DOI: 10.1038/nrg2303  0.694
2007 Lemaitre B, Hoffmann J. The host defense of Drosophila melanogaster. Annual Review of Immunology. 25: 697-743. PMID 17201680 DOI: 10.1146/Annurev.Immunol.25.022106.141615  0.473
2007 Acosta Muniz C, Jaillard D, Lemaitre B, Boccard F. Erwinia carotovora Evf antagonizes the elimination of bacteria in the gut of Drosophila larvae. Cellular Microbiology. 9: 106-19. PMID 16879453 DOI: 10.1111/J.1462-5822.2006.00771.X  0.522
2006 Leulier F, Lhocine N, Lemaitre B, Meier P. The Drosophila inhibitor of apoptosis protein DIAP2 functions in innate immunity and is essential to resist gram-negative bacterial infection. Molecular and Cellular Biology. 26: 7821-31. PMID 16894030 DOI: 10.1128/Mcb.00548-06  0.814
2006 Bangham J, Jiggins F, Lemaitre B. Insect immunity: the post-genomic era. Immunity. 25: 1-5. PMID 16892501 DOI: 10.1016/j.immuni.2006.07.002  0.469
2006 Tang H, Kambris Z, Lemaitre B, Hashimoto C. Two proteases defining a melanization cascade in the immune system of Drosophila. The Journal of Biological Chemistry. 281: 28097-104. PMID 16861233 DOI: 10.1074/Jbc.M601642200  0.55
2006 Liehl P, Blight M, Vodovar N, Boccard F, Lemaitre B. Prevalence of local immune response against oral infection in a Drosophila/Pseudomonas infection model. Plos Pathogens. 2: e56. PMID 16789834 DOI: 10.1371/Journal.Ppat.0020056  0.845
2006 Vodovar N, Vallenet D, Cruveiller S, Rouy Z, Barbe V, Acosta C, Cattolico L, Jubin C, Lajus A, Segurens B, Vacherie B, Wincker P, Weissenbach J, Lemaitre B, Médigue C, et al. Complete genome sequence of the entomopathogenic and metabolically versatile soil bacterium Pseudomonas entomophila. Nature Biotechnology. 24: 673-9. PMID 16699499 DOI: 10.1038/Nbt1212  0.671
2006 Scherfer C, Qazi MR, Takahashi K, Ueda R, Dushay MS, Theopold U, Lemaitre B. The Toll immune-regulated Drosophila protein Fondue is involved in hemolymph clotting and puparium formation. Developmental Biology. 295: 156-63. PMID 16690050 DOI: 10.1016/j.ydbio.2006.03.019  0.828
2006 Kambris Z, Brun S, Jang IH, Nam HJ, Romeo Y, Takahashi K, Lee WJ, Ueda R, Lemaitre B. Drosophila immunity: a large-scale in vivo RNAi screen identifies five serine proteases required for Toll activation. Current Biology : Cb. 16: 808-13. PMID 16631589 DOI: 10.1016/j.cub.2006.03.020  0.502
2006 Zaidman-Rémy A, Hervé M, Poidevin M, Pili-Floury S, Kim MS, Blanot D, Oh BH, Ueda R, Mengin-Lecreulx D, Lemaitre B. The Drosophila amidase PGRP-LB modulates the immune response to bacterial infection. Immunity. 24: 463-73. PMID 16618604 DOI: 10.1016/J.Immuni.2006.02.012  0.838
2006 Brun S, Vidal S, Spellman P, Takahashi K, Tricoire H, Lemaitre B. The MAPKKK Mekk1 regulates the expression of Turandot stress genes in response to septic injury in Drosophila. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 11: 397-407. PMID 16611243 DOI: 10.1111/J.1365-2443.2006.00953.X  0.815
2006 Jang IH, Chosa N, Kim SH, Nam HJ, Lemaitre B, Ochiai M, Kambris Z, Brun S, Hashimoto C, Ashida M, Brey PT, Lee WJ. A Spätzle-processing enzyme required for toll signaling activation in Drosophila innate immunity. Developmental Cell. 10: 45-55. PMID 16399077 DOI: 10.1016/J.Devcel.2005.11.013  0.478
2005 Kleino A, Valanne S, Ulvila J, Kallio J, Myllymäki H, Enwald H, Stöven S, Poidevin M, Ueda R, Hultmark D, Lemaitre B, Rämet M. Inhibitor of apoptosis 2 and TAK1-binding protein are components of the Drosophila Imd pathway. The Embo Journal. 24: 3423-34. PMID 16163390 DOI: 10.1038/sj.emboj.7600807  0.468
2005 Vodovar N, Vinals M, Liehl P, Basset A, Degrouard J, Spellman P, Boccard F, Lemaitre B. Drosophila host defense after oral infection by an entomopathogenic Pseudomonas species. Proceedings of the National Academy of Sciences of the United States of America. 102: 11414-9. PMID 16061818 DOI: 10.1073/Pnas.0502240102  0.844
2005 Mengin-Lecreulx D, Lemaitre B. Structure and metabolism of peptidoglycan and molecular requirements allowing its detection by the Drosophila innate immune system. Journal of Endotoxin Research. 11: 105-11. PMID 15949137 DOI: 10.1179/096805105X35233  0.47
2004 Stenbak CR, Ryu JH, Leulier F, Pili-Floury S, Parquet C, Hervé M, Chaput C, Boneca IG, Lee WJ, Lemaitre B, Mengin-Lecreulx D. Peptidoglycan molecular requirements allowing detection by the Drosophila immune deficiency pathway. Journal of Immunology (Baltimore, Md. : 1950). 173: 7339-48. PMID 15585858 DOI: 10.4049/Jimmunol.173.12.7339  0.759
2004 Chang CI, Pili-Floury S, Hervé M, Parquet C, Chelliah Y, Lemaitre B, Mengin-Lecreulx D, Deisenhofer J. A Drosophila pattern recognition receptor contains a peptidoglycan docking groove and unusual L,D-carboxypeptidase activity. Plos Biology. 2: E277. PMID 15361936 DOI: 10.1371/Journal.Pbio.0020277  0.424
2004 Lemaitre B. The road to Toll. Nature Reviews. Immunology. 4: 521-7. PMID 15229471 DOI: 10.1038/nri1390  0.537
2004 Vodovar N, Acosta C, Lemaitre B, Boccard F. Drosophila: a polyvalent model to decipher host-pathogen interactions. Trends in Microbiology. 12: 235-42. PMID 15120143 DOI: 10.1016/J.Tim.2004.03.007  0.756
2004 Pili-Floury S, Leulier F, Takahashi K, Saigo K, Samain E, Ueda R, Lemaitre B. In vivo RNA interference analysis reveals an unexpected role for GNBP1 in the defense against Gram-positive bacterial infection in Drosophila adults. The Journal of Biological Chemistry. 279: 12848-53. PMID 14722090 DOI: 10.1074/jbc.M313324200  0.753
2003 Girardin SE, Philpott DJ, Lemaitre B. Sensing microbes by diverse hosts. Workshop on pattern recognition proteins and receptors. Embo Reports. 4: 932-6. PMID 14502224 DOI: 10.1038/Sj.Embor.Embor940  0.562
2003 Leulier F, Marchal C, Miletich I, Limbourg-Bouchon B, Benarous R, Lemaitre B. Directed expression of the HIV-1 accessory protein Vpu in Drosophila fat-body cells inhibits Toll-dependent immune responses. Embo Reports. 4: 976-81. PMID 12973300 DOI: 10.1038/sj.embor.embor936  0.728
2003 Leulier F, Parquet C, Pili-Floury S, Ryu JH, Caroff M, Lee WJ, Mengin-Lecreulx D, Lemaitre B. The Drosophila immune system detects bacteria through specific peptidoglycan recognition. Nature Immunology. 4: 478-84. PMID 12692550 DOI: 10.1038/ni922  0.753
2003 Basset A, Tzou P, Lemaitre B, Boccard F. A single gene that promotes interaction of a phytopathogenic bacterium with its insect vector, Drosophila melanogaster. Embo Reports. 4: 205-9. PMID 12612613 DOI: 10.1038/Sj.Embor.Embor730  0.518
2002 De Gregorio E, Han SJ, Lee WJ, Baek MJ, Osaki T, Kawabata S, Lee BL, Iwanaga S, Lemaitre B, Brey PT. An immune-responsive Serpin regulates the melanization cascade in Drosophila. Developmental Cell. 3: 581-92. PMID 12408809 DOI: 10.1016/S1534-5807(02)00267-8  0.435
2002 Khush RS, Cornwell WD, Uram JN, Lemaitre B. A ubiquitin-proteasome pathway represses the Drosophila immune deficiency signaling cascade. Current Biology : Cb. 12: 1728-37. PMID 12401167 DOI: 10.1016/S0960-9822(02)01214-9  0.507
2002 Leulier F, Vidal S, Saigo K, Ueda R, Lemaitre B. Inducible expression of double-stranded RNA reveals a role for dFADD in the regulation of the antibacterial response in Drosophila adults. Current Biology : Cb. 12: 996-1000. PMID 12123572 DOI: 10.1016/S0960-9822(02)00873-4  0.815
2002 De Gregorio E, Spellman PT, Tzou P, Rubin GM, Lemaitre B. The Toll and Imd pathways are the major regulators of the immune response in Drosophila. The Embo Journal. 21: 2568-79. PMID 12032070 DOI: 10.1093/Emboj/21.11.2568  0.558
2002 Khush RS, Leulier F, Lemaitre B. Immunology. Pathogen surveillance--the flies have it. Science (New York, N.Y.). 296: 273-5. PMID 11951023 DOI: 10.1126/science.1071208  0.67
2002 Tzou P, Reichhart JM, Lemaitre B. Constitutive expression of a single antimicrobial peptide can restore wild-type resistance to infection in immunodeficient Drosophila mutants. Proceedings of the National Academy of Sciences of the United States of America. 99: 2152-7. PMID 11854512 DOI: 10.1073/pnas.042411999  0.491
2002 Tzou P, De Gregorio E, Lemaitre B. How Drosophila combats microbial infection: a model to study innate immunity and host-pathogen interactions. Current Opinion in Microbiology. 5: 102-10. PMID 11834378 DOI: 10.1016/S1369-5274(02)00294-1  0.514
2002 Tzou P, Meister M, Lemaitre B. 27 Methods for studying infection and immunity in Drosophila Methods in Microbiology. 31: 507-529. DOI: 10.1016/S0580-9517(02)31028-6  0.502
2001 De Gregorio E, Spellman PT, Rubin GM, Lemaitre B. Genome-wide analysis of the Drosophila immune response by using oligonucleotide microarrays. Proceedings of the National Academy of Sciences of the United States of America. 98: 12590-5. PMID 11606746 DOI: 10.1073/Pnas.221458698  0.546
2001 Vidal S, Khush RS, Leulier F, Tzou P, Nakamura M, Lemaitre B. Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-kappaB-dependent innate immune responses. Genes & Development. 15: 1900-12. PMID 11485985 DOI: 10.1101/Gad.203301  0.819
2001 Khush RS, Leulier F, Lemaitre B. Drosophila immunity: two paths to NF-kappaB. Trends in Immunology. 22: 260-4. PMID 11323284 DOI: 10.1016/S1471-4906(01)01887-7  0.774
2000 Leulier F, Rodriguez A, Khush RS, Abrams JM, Lemaitre B. The Drosophila caspase Dredd is required to resist gram-negative bacterial infection. Embo Reports. 1: 353-8. PMID 11269502 DOI: 10.1093/Embo-Reports/Kvd073  0.779
2000 Tzou P, Ohresser S, Ferrandon D, Capovilla M, Reichhart JM, Lemaitre B, Hoffmann JA, Imler JL. Tissue-specific inducible expression of antimicrobial peptide genes in Drosophila surface epithelia. Immunity. 13: 737-48. PMID 11114385 DOI: 10.1016/S1074-7613(00)00072-8  0.479
2000 Khush RS, Lemaitre B. Stop press: genes that fight infections: what the drosophila genome says about animal immunity Trends in Genetics : Tig. 16: 468. PMID 11050334 DOI: 10.1016/S0168-9525(00)02133-8  0.405
2000 Khush RS, Lemaitre B. Genes that fight infection: what the Drosophila genome says about animal immunity. Trends in Genetics : Tig. 16: 442-9. PMID 11050330 DOI: 10.1016/S0168-9525(00)02095-3  0.524
2000 Kim YS, Ryu JH, Han SJ, Choi KH, Nam KB, Jang IH, Lemaitre B, Brey PT, Lee WJ. Gram-negative bacteria-binding protein, a pattern recognition receptor for lipopolysaccharide and beta-1,3-glucan that mediates the signaling for the induction of innate immune genes in Drosophila melanogaster cells. The Journal of Biological Chemistry. 275: 32721-7. PMID 10827089 DOI: 10.1074/jbc.M003934200  0.476
2000 Rubin GM, Yandell MD, Wortman JR, Gabor Miklos GL, Nelson CR, Hariharan IK, Fortini ME, Li PW, Apweiler R, Fleischmann W, Cherry JM, Henikoff S, Skupski MP, Misra S, Ashburner M, ... ... Lemaitre B, et al. Comparative genomics of the eukaryotes. Science (New York, N.Y.). 287: 2204-15. PMID 10731134 DOI: 10.1126/Science.287.5461.2204  0.333
2000 Basset A, Khush RS, Braun A, Gardan L, Boccard F, Hoffmann JA, Lemaitre B. The phytopathogenic bacteria Erwinia carotovora infects Drosophila and activates an immune response. Proceedings of the National Academy of Sciences of the United States of America. 97: 3376-81. PMID 10725405 DOI: 10.1073/Pnas.070357597  0.566
1999 Manfruelli P, Reichhart JM, Steward R, Hoffmann JA, Lemaitre B. A mosaic analysis in Drosophila fat body cells of the control of antimicrobial peptide genes by the Rel proteins Dorsal and DIF. The Embo Journal. 18: 3380-91. PMID 10369678 DOI: 10.1093/Emboj/18.12.3380  0.469
1999 Lemaitre B. Drosophila: A model for the understanding of innate immunity Medecine/Sciences. 15: 15-22.  0.329
1998 Levashina EA, Ohresser S, Lemaitre B, Imler JL. Two distinct pathways can control expression of the gene encoding the Drosophila antimicrobial peptide metchnikowin. Journal of Molecular Biology. 278: 515-27. PMID 9600835 DOI: 10.1006/jmbi.1998.1705  0.509
1998 Nicolas E, Reichhart JM, Hoffmann JA, Lemaitre B. In vivo regulation of the IkappaB homologue cactus during the immune response of Drosophila. The Journal of Biological Chemistry. 273: 10463-9. PMID 9553105 DOI: 10.1074/Jbc.273.17.10463  0.724
1998 Ferrandon D, Jung AC, Criqui M, Lemaitre B, Uttenweiler-Joseph S, Michaut L, Reichhart J, Hoffmann JA. A drosomycin-GFP reporter transgene reveals a local immune response in Drosophila that is not dependent on the Toll pathway. The Embo Journal. 17: 1217-27. PMID 9482719 DOI: 10.1093/Emboj/17.5.1217  0.507
1997 Lemaitre B, Reichhart JM, Hoffmann JA. Drosophila host defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganisms. Proceedings of the National Academy of Sciences of the United States of America. 94: 14614-9. PMID 9405661 DOI: 10.1073/Pnas.94.26.14614  0.479
1997 Meister M, Lemaitre B, Hoffmann JA. Antimicrobial peptide defense in Drosophila. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 19: 1019-26. PMID 9394624 DOI: 10.1002/Bies.950191112  0.453
1996 Nicolas E, Nappi AJ, Lemaitre B. Expression of antimicrobial peptide genes after infection by parasitoid wasps in Drosophila. Developmental and Comparative Immunology. 20: 175-81. PMID 8955592 DOI: 10.1016/0145-305X(96)00017-1  0.685
1996 Lemaitre B, Nicolas E, Michaut L, Reichhart JM, Hoffmann JA. The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell. 86: 973-83. PMID 8808632 DOI: 10.1016/S0092-8674(00)80172-5  0.72
1995 Lemaitre B, Meister M, Govind S, Georgel P, Steward R, Reichhart JM, Hoffmann JA. Functional analysis and regulation of nuclear import of dorsal during the immune response in Drosophila. The Embo Journal. 14: 536-45. PMID 7859742 DOI: 10.1002/J.1460-2075.1995.Tb07029.X  0.491
1995 Lemaitre B, Kromer-Metzger E, Michaut L, Nicolas E, Meister M, Georgel P, Reichhart JM, Hoffmann JA. A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense. Proceedings of the National Academy of Sciences of the United States of America. 92: 9465-9. PMID 7568155 DOI: 10.1073/Pnas.92.21.9465  0.674
1994 Coen D, Lemaitre B, Delattre M, Quesneville H, Ronsseray S, Simonelig M, Higuet D, Lehmann M, Montchamp C, Nouaud D. Drosophila P element: transposition, regulation and evolution. Genetica. 93: 61-78. PMID 7813918 DOI: 10.1007/BF01435240  0.308
1993 Reichhart JM, Georgel P, Meister M, Lemaitre B, Kappler C, Hoffmann JA. Expression and nuclear translocation of the rel/NF-kappa B-related morphogen dorsal during the immune response of Drosophila. Comptes Rendus De L'Acadã©Mie Des Sciences. Sã©Rie Iii, Sciences De La Vie. 316: 1218-24. PMID 8062131  0.37
1993 Georgel P, Meister M, Kappler C, Lemaitre B, Reichhart JM, Hoffmann JA. Insect immunity: the diptericin promoter contains multiple functional regulatory sequences homologous to mammalian acute-phase response elements. Biochemical and Biophysical Research Communications. 197: 508-17. PMID 7505569 DOI: 10.1006/Bbrc.1993.2508  0.438
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