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Linda Partridge - Publications

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Year Citation  Score
2024 Ureña E, Xu B, Regan JC, Atilano ML, Minkley LJ, Filer D, Lu YX, Bolukbasi E, Khericha M, Alic N, Partridge L. Trametinib ameliorates aging-associated gut pathology in females by reducing Pol III activity in intestinal stem cells. Proceedings of the National Academy of Sciences of the United States of America. 121: e2311313121. PMID 38241436 DOI: 10.1073/pnas.2311313121  0.798
2023 Debès C, Papadakis A, Grönke S, Karalay Ö, Tain LS, Mizi A, Nakamura S, Hahn O, Weigelt C, Josipovic N, Zirkel A, Brusius I, Sofiadis K, Lamprousi M, Lu YX, ... ... Partridge L, et al. Ageing-associated changes in transcriptional elongation influence longevity. Nature. PMID 37046086 DOI: 10.1038/s41586-023-05922-y  0.764
2022 Regan JC, Lu YX, Ureña E, Meilenbrock RL, Catterson JH, Kißler D, Fröhlich J, Funk E, Partridge L. Sexual identity of enterocytes regulates autophagy to determine intestinal health, lifespan and responses to rapamycin. Nature Aging. 2: 1145-1158. PMID 37118538 DOI: 10.1038/s43587-022-00308-7  0.8
2022 Juricic P, Lu YX, Leech T, Drews LF, Paulitz J, Lu J, Nespital T, Azami S, Regan JC, Funk E, Fröhlich J, Grönke S, Partridge L. Long-lasting geroprotection from brief rapamycin treatment in early adulthood by persistently increased intestinal autophagy. Nature Aging. 2: 824-836. PMID 37118497 DOI: 10.1038/s43587-022-00278-w  0.779
2022 Laskovs M, Partridge L, Slack C. Molecular inhibition of RAS signalling to target ageing and age-related health. Disease Models & Mechanisms. 15. PMID 36111627 DOI: 10.1242/dmm.049627  0.743
2022 Meron E, Thaysen M, Angeli S, Antebi A, Barzilai N, Baur JA, Bekker-Jensen S, Birkisdottir M, Bischof E, Bruening J, Brunet A, Buchwalter A, Cabreiro F, Cai S, Chen BH, ... ... Partridge L, et al. Meeting Report: Aging Research and Drug Discovery. Aging. 14. PMID 35089871 DOI: 10.18632/aging.203859  0.743
2021 Aman Y, Schmauck-Medina T, Hansen M, Morimoto RI, Simon AK, Bjedov I, Palikaras K, Simonsen A, Johansen T, Tavernarakis N, Rubinsztein DC, Partridge L, Kroemer G, Labbadia J, Fang EF. Autophagy in healthy aging and disease. Nature Aging. 1: 634-650. PMID 34901876 DOI: 10.1038/s43587-021-00098-4  0.722
2021 Lu YX, Regan JC, Eßer J, Drews LF, Weinseis T, Stinn J, Hahn O, Miller RA, Grönke S, Partridge L. A TORC1-histone axis regulates chromatin organisation and non-canonical induction of autophagy to ameliorate ageing. Elife. 10. PMID 33988501 DOI: 10.7554/eLife.62233  0.782
2020 Bjedov I, Cochemé HM, Foley A, Wieser D, Woodling NS, Castillo-Quan JI, Norvaisas P, Lujan C, Regan J, Toivonen JM, Murphy MP, Thornton J, Kinghorn KJ, Neufeld TP, Cabreiro F, ... Partridge L, et al. Fine-tuning autophagy maximises lifespan and is associated with changes in mitochondrial gene expression in Drosophila. Plos Genetics. 16: e1009083. PMID 33253201 DOI: 10.1371/journal.pgen.1009083  0.803
2020 Woodling NS, Rajasingam A, Minkley LJ, Rizzo A, Partridge L. Independent glial subtypes delay development and extend healthy lifespan upon reduced insulin-PI3K signalling. Bmc Biology. 18: 124. PMID 32928209 DOI: 10.1186/s12915-020-00854-9  0.393
2020 Weigelt CM, Sehgal R, Tain LS, Cheng J, Eßer J, Pahl A, Dieterich C, Grönke S, Partridge L. An Insulin-Sensitive Circular RNA that Regulates Lifespan in Drosophila. Molecular Cell. PMID 32592682 DOI: 10.1016/j.molcel.2020.06.011  0.379
2020 Yu Y, Niccoli T, Ren Z, Woodling NS, Aleyakpo B, Szabadkai G, Partridge L. PICALM rescues glutamatergic neurotransmission, behavioural function, and survival in a Drosophila model of Aβ42 toxicity. Human Molecular Genetics. PMID 32592479 DOI: 10.1093/Hmg/Ddaa125  0.562
2020 Partridge L, Fuentealba M, Kennedy BK. The quest to slow ageing through drug discovery. Nature Reviews. Drug Discovery. PMID 32467649 DOI: 10.1038/S41573-020-0067-7  0.351
2020 Woodling NS, Aleyakpo B, Dyson MC, Minkley LJ, Rajasingam A, Dobson AJ, Leung KHC, Pomposova S, Fuentealba M, Alic N, Partridge L. The neuronal receptor tyrosine kinase Alk is a target for longevity. Aging Cell. e13137. PMID 32291952 DOI: 10.1111/Acel.13137  0.716
2019 Morón-Oset J, Supèr T, Esser J, Isaacs AM, Grönke S, Partridge L. Glycine-alanine dipeptide repeats spread rapidly in a repeat length- and age-dependent manner in the fly brain. Acta Neuropathologica Communications. 7: 209. PMID 31843021 DOI: 10.1186/s40478-019-0860-x  0.317
2019 Hahn O, Drews LF, Nguyen A, Tatsuta T, Gkioni L, Hendrich O, Zhang Q, Langer T, Pletcher S, Wakelam MJO, Beyer A, Grönke S, Partridge L. A nutritional memory effect counteracts benefits of dietary restriction in old mice. Nature Metabolism. 1: 1059-1073. PMID 31742247 DOI: 10.1038/s42255-019-0121-0  0.553
2019 Tain LS, Jain C, Nespital T, Froehlich J, Hinze Y, Grönke S, Partridge L. Longevity in response to lowered insulin signaling requires glycine N-methyltransferase-dependent spermidine production. Aging Cell. e13043. PMID 31721422 DOI: 10.1111/acel.13043  0.381
2019 Castillo-Quan JI, Tain LS, Kinghorn KJ, Li L, Grönke S, Hinze Y, Blackwell TK, Bjedov I, Partridge L. A triple drug combination targeting components of the nutrient-sensing network maximizes longevity. Proceedings of the National Academy of Sciences of the United States of America. PMID 31570569 DOI: 10.1073/Pnas.1913212116  0.738
2019 Juricic P, Grönke S, Partridge L. Branched-chain amino acids have equivalent effects to other essential amino acids on lifespan and ageing-related traits in Drosophila. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. PMID 30891588 DOI: 10.1093/gerona/glz080  0.358
2019 Fuentealba M, Dönertaş HM, Williams R, Labbadia J, Thornton JM, Partridge L. Using the drug-protein interactome to identify anti-ageing compounds for humans. Plos Computational Biology. 15: e1006639. PMID 30625143 DOI: 10.1371/Journal.Pcbi.1006639  0.329
2019 Partridge L, Prowse N. The effects of reproduction on longevity and fertility in male Drosophila melanogaster. Journal of Insect Physiology. 43: 501-512. PMID 12770412 DOI: 10.1016/S0022-1910(97)00014-0  0.336
2018 Dönertaş HM, Fuentealba M, Partridge L, Thornton JM. Identifying Potential Ageing-Modulating Drugs In Silico. Trends in Endocrinology and Metabolism: Tem. PMID 30581056 DOI: 10.1016/J.Tem.2018.11.005  0.335
2018 Hahn O, Stubbs TM, Reik W, Grönke S, Beyer A, Partridge L. Hepatic gene body hypermethylation is a shared epigenetic signature of murine longevity. Plos Genetics. 14: e1007766. PMID 30462643 DOI: 10.1371/Journal.Pgen.1007766  0.331
2018 Kauppila TES, Bratic A, Jensen MB, Baggio F, Partridge L, Jasper H, Grönke S, Larsson NG. Mutations of mitochondrial DNA are not major contributors to aging of fruit flies. Proceedings of the National Academy of Sciences of the United States of America. PMID 30249665 DOI: 10.1073/Pnas.1721683115  0.308
2018 Partridge L, Deelen J, Slagboom PE. Facing up to the global challenges of ageing. Nature. 561: 45-56. PMID 30185958 DOI: 10.1038/s41586-018-0457-8  0.31
2018 Flatt T, Partridge L. Horizons in the evolution of aging. Bmc Biology. 16: 93. PMID 30124168 DOI: 10.1186/S12915-018-0562-Z  0.376
2018 Dönertaş HM, Fuentealba Valenzuela M, Partridge L, Thornton JM. Gene Expression-Based Drug Repurposing to Target Ageing. Aging Cell. e12819. PMID 29959820 DOI: 10.1111/Acel.12819  0.346
2018 Catterson JH, Khericha M, Dyson MC, Vincent AJ, Callard R, Haveron SM, Rajasingam A, Ahmad M, Partridge L. Short-Term, Intermittent Fasting Induces Long-Lasting Gut Health and TOR-Independent Lifespan Extension. Current Biology : Cb. PMID 29779873 DOI: 10.1016/j.cub.2018.04.015  0.349
2018 Augustin H, McGourty K, Allen MJ, Adcott J, Wong CT, Boucrot E, Partridge L. Impact of insulin signaling and proteasomal activity on physiological output of a neuronal circuit in aging Drosophila melanogaster. Neurobiology of Aging. 66: 149-157. PMID 29579685 DOI: 10.1016/J.Neurobiolaging.2018.02.027  0.38
2017 Bolukbasi E, Khericha M, Regan JC, Ivanov DK, Adcott J, Dyson MC, Nespital T, Thornton JM, Alic N, Partridge L. Intestinal Fork Head Regulates Nutrient Absorption and Promotes Longevity. Cell Reports. 21: 641-653. PMID 29045833 DOI: 10.1016/J.Celrep.2017.09.042  0.811
2017 Niccoli T, Partridge L, Isaacs AM. Ageing as a risk factor for ALS/FTD. Human Molecular Genetics. 26: R105-R113. PMID 28977441 DOI: 10.1093/hmg/ddx247  0.356
2017 Piper MDW, Partridge L. Drosophila as a model for ageing. Biochimica Et Biophysica Acta. PMID 28964875 DOI: 10.1016/J.Bbadis.2017.09.016  0.408
2017 Tain LS, Sehlke R, Jain C, Chokkalingam M, Nagaraj N, Essers P, Rassner M, Grönke S, Froelich J, Dieterich C, Mann M, Alic N, Beyer A, Partridge L. A proteomic atlas of insulin signalling reveals tissue-specific mechanisms of longevity assurance. Molecular Systems Biology. 13: 939. PMID 28916541 DOI: 10.15252/Msb.20177663  0.72
2017 Augustin H, McGourty K, Allen MJ, Madem SK, Adcott J, Kerr F, Wong CT, Vincent A, Godenschwege T, Boucrot E, Partridge L. Reduced insulin signaling maintains electrical transmission in a neural circuit in aging flies. Plos Biology. 15: e2001655. PMID 28902870 DOI: 10.1371/Journal.Pbio.2001655  0.379
2017 Augustin H, Adcott J, Elliott CJH, Partridge L. Complex Roles of Myoglianin in Regulating Adult Performance and Lifespan. Fly. 0. PMID 28837401 DOI: 10.1080/19336934.2017.1369638  0.368
2017 Bustos V, Partridge L. Good Ol' Fat: Links between Lipid Signaling and Longevity. Trends in Biochemical Sciences. PMID 28802547 DOI: 10.1016/j.tibs.2017.07.001  0.358
2017 Brandt T, Mourier A, Tain LS, Partridge L, Larsson NG, Kühlbrandt W. Changes of mitochondrial ultrastructure and function during ageing in mice and Drosophila. Elife. 6. PMID 28699890 DOI: 10.7554/Elife.24662  0.332
2017 Ziehm M, Kaur S, Ivanov DK, Ballester PJ, Marcus D, Partridge L, Thornton JM. Drug repurposing for aging research using model organisms. Aging Cell. PMID 28620943 DOI: 10.1111/Acel.12626  0.361
2017 Hahn O, Grönke S, Stubbs TM, Ficz G, Hendrich O, Krueger F, Andrews S, Zhang Q, Wakelam MJ, Beyer A, Reik W, Partridge L. Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism. Genome Biology. 18: 56. PMID 28351387 DOI: 10.1186/S13059-017-1187-1  0.354
2017 Piper MD, Soultoukis GA, Blanc E, Mesaros A, Herbert SL, Juricic P, He X, Atanassov I, Salmonowicz H, Yang M, Simpson SJ, Ribeiro C, Partridge L. Matching Dietary Amino Acid Balance to the In Silico-Translated Exome Optimizes Growth and Reproduction without Cost to Lifespan. Cell Metabolism. 25: 610-621. PMID 28273481 DOI: 10.1016/J.Cmet.2017.02.005  0.67
2016 Tiku V, Jain C, Raz Y, Nakamura S, Heestand B, Liu W, Späth M, Suchiman HED, Müller RU, Slagboom PE, Partridge L, Antebi A. Small nucleoli are a cellular hallmark of longevity. Nature Communications. 8: 16083. PMID 28853436 DOI: 10.1038/ncomms16083  0.375
2016 Kinghorn KJ, Grönke S, Castillo-Quan JI, Woodling NS, Li L, Sirka E, Gegg M, Mills K, Hardy J, Bjedov I, Partridge L. A Drosophila Model of Neuronopathic Gaucher Disease Demonstrates Lysosomal-Autophagic Defects and Altered mTOR Signalling and Is Functionally Rescued by Rapamycin. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 11654-11670. PMID 27852774 DOI: 10.1523/Jneurosci.4527-15.2016  0.725
2016 Piper MD, Partridge L. Protocols to Study Aging in Drosophila. Methods in Molecular Biology (Clifton, N.J.). 1478: 291-302. PMID 27730590 DOI: 10.1007/978-1-4939-6371-3_18  0.7
2016 Kakanj P, Moussian B, Grönke S, Bustos V, Eming SA, Partridge L, Leptin M. Insulin and TOR signal in parallel through FOXO and S6K to promote epithelial wound healing. Nature Communications. 7: 12972. PMID 27713427 DOI: 10.1038/ncomms12972  0.341
2016 Essers P, Tain LS, Nespital T, Goncalves J, Froehlich J, Partridge L. Reduced insulin/insulin-like growth factor signaling decreases translation in Drosophila and mice. Scientific Reports. 6: 30290. PMID 27452396 DOI: 10.1038/srep30290  0.357
2016 Soultoukis GA, Partridge L. Dietary Protein, Metabolism, and Aging. Annual Review of Biochemistry. PMID 27145842 DOI: 10.1146/annurev-biochem-060815-014422  0.387
2016 Castillo-Quan JI, Li L, Kinghorn KJ, Ivanov DK, Tain LS, Slack C, Kerr F, Nespital T, Thornton J, Hardy J, Bjedov I, Partridge L. Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis. Cell Reports. PMID 27068460 DOI: 10.1016/J.Celrep.2016.03.041  0.801
2016 Burnouf S, Grönke S, Augustin H, Dols J, Gorsky MK, Werner J, Kerr F, Alic N, Martinez P, Partridge L. Deletion of endogenous Tau proteins is not detrimental in Drosophila. Scientific Reports. 6: 23102. PMID 26976084 DOI: 10.1038/Srep23102  0.668
2016 Regan JC, Khericha M, Dobson AJ, Bolukbasi E, Rattanavirotkul N, Partridge L. Sex difference in pathology of the ageing gut mediates the greater response of female lifespan to dietary restriction. Elife. 5. PMID 26878754 DOI: 10.7554/eLife.10956  0.725
2016 Afschar S, Toivonen JM, Hoffmann JM, Tain LS, Wieser D, Finlayson AJ, Driege Y, Alic N, Emran S, Stinn J, Froehlich J, Piper MD, Partridge L. Nuclear hormone receptor DHR96 mediates the resistance to xenobiotics but not the increased lifespan of insulin-mutant Drosophila. Proceedings of the National Academy of Sciences of the United States of America. PMID 26787908 DOI: 10.1073/Pnas.1515137113  0.801
2016 Kinghorn K, Gronke S, Castillo-Quan JI, Li L, Woodling N, Sirka E, Gegg M, Hardy J, Partridge L. A NOVEL MODEL OF GBA1-ASSOCIATED PARKINSON'S DISEASE IMPLICATES AUTOPHAGY Journal of Neurology, Neurosurgery & Psychiatry. 87: e1.68-e1. DOI: 10.1136/Jnnp-2016-315106.16  0.301
2015 Kerr F, Augustin H, Piper MDW, Gandy C, Allen MJ, Lovestone S, Partridge L. Erratum to "Dietary restriction delays aging, but not neuronal dysfunction, in Drosophila models of Alzheimer's disease." [Neurobiol. Aging 32 (2011) 1977-1989]. Neurobiology of Aging. 36: 2331. PMID 28843333 DOI: 10.1016/J.Neurobiolaging.2015.05.007  0.324
2015 Armanios M, de Cabo R, Mannick J, Partridge L, van Deursen J, Villeda S. Translational strategies in aging and age-related disease. Nature Medicine. 21: 1395-9. PMID 26646495 DOI: 10.1038/Nm.4004  0.324
2015 Slack C, Alic N, Partridge L. Could cancer drugs provide ammunition against ageing? Cell Cycle (Georgetown, Tex.). 0. PMID 26587873 DOI: 10.1080/15384101.2015.1118905  0.769
2015 Hoffmann JM, Partridge L. Nuclear hormone receptors: Roles of xenobiotic detoxification and sterol homeostasis in healthy aging. Critical Reviews in Biochemistry and Molecular Biology. 50: 380-92. PMID 26383043 DOI: 10.3109/10409238.2015.1067186  0.385
2015 Slack C, Alic N, Foley A, Cabecinha M, Hoddinott MP, Partridge L. The Ras-Erk-ETS-Signaling Pathway Is a Drug Target for Longevity. Cell. 162: 72-83. PMID 26119340 DOI: 10.1016/J.Cell.2015.06.023  0.786
2015 Menger KE, James AM, Cochemé HM, Harbour ME, Chouchani ET, Ding S, Fearnley IM, Partridge L, Murphy MP. Fasting, but Not Aging, Dramatically Alters the Redox Status of Cysteine Residues on Proteins in Drosophila melanogaster. Cell Reports. 11: 1856-65. PMID 26095360 DOI: 10.1016/j.celrep.2015.05.033  0.302
2015 Ivanov DK, Escott-Price V, Ziehm M, Magwire MM, Mackay TF, Partridge L, Thornton JM. Longevity GWAS Using the Drosophila Genetic Reference Panel. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. PMID 25922346 DOI: 10.1093/Gerona/Glv047  0.325
2015 Fontana L, Partridge L. Promoting health and longevity through diet: from model organisms to humans. Cell. 161: 106-18. PMID 25815989 DOI: 10.1016/j.cell.2015.02.020  0.361
2015 Alic N, Partridge L. Myc mouse and anti-ageing therapy. Trends in Endocrinology and Metabolism: Tem. 26: 163-4. PMID 25727046 DOI: 10.1016/J.Tem.2015.02.005  0.702
2015 Piper MDW, Blanc E, Leitão-Gonçalves R, Yang M, He X, Linford NJ, Hoddinott MP, Hopfen C, Soultoukis GA, Niemeyer C, Kerr F, Pletcher SD, Ribeiro C, Partridge L. Erratum: Corrigendum: A holidic medium for Drosophila melanogaster Nature Methods. 12: 1098-1098. DOI: 10.1038/Nmeth1115-1098D  0.552
2014 Piper MD, Selman C, Speakman JR, Partridge L. Using doubly-labeled water to measure energy expenditure in an important small ectotherm Drosophila melanogaster. Journal of Genetics and Genomics = Yi Chuan Xue Bao. 41: 505-12. PMID 25269676 DOI: 10.1016/J.Jgg.2014.07.004  0.669
2014 Alic N, Giannakou ME, Papatheodorou I, Hoddinott MP, Andrews TD, Bolukbasi E, Partridge L. Interplay of dFOXO and two ETS-family transcription factors determines lifespan in Drosophila melanogaster. Plos Genetics. 10: e1004619. PMID 25232726 DOI: 10.1371/Journal.Pgen.1004619  0.696
2014 Partridge L. Intervening in ageing to prevent the diseases of ageing. Trends in Endocrinology and Metabolism: Tem. 25: 555-7. PMID 25175302 DOI: 10.1016/j.tem.2014.08.003  0.371
2014 Sofola-Adesakin O, Castillo-Quan JI, Rallis C, Tain LS, Bjedov I, Rogers I, Li L, Martinez P, Khericha M, Cabecinha M, Bähler J, Partridge L. Lithium suppresses Aβ pathology by inhibiting translation in an adult Drosophila model of Alzheimer's disease. Frontiers in Aging Neuroscience. 6: 190. PMID 25126078 DOI: 10.3389/Fnagi.2014.00190  0.713
2014 Alic N, Tullet JM, Niccoli T, Broughton S, Hoddinott MP, Slack C, Gems D, Partridge L. Cell-nonautonomous effects of dFOXO/DAF-16 in aging. Cell Reports. 6: 608-16. PMID 24508462 DOI: 10.1016/J.Celrep.2014.01.015  0.805
2014 Piper MD, Blanc E, Leitão-Gonçalves R, Yang M, He X, Linford NJ, Hoddinott MP, Hopfen C, Soultoukis GA, Niemeyer C, Kerr F, Pletcher SD, Ribeiro C, Partridge L. A holidic medium for Drosophila melanogaster. Nature Methods. 11: 100-5. PMID 24240321 DOI: 10.1038/Nmeth.2731  0.745
2014 Piper MDW, Blanc E, Leitão-Gonçalves R, Yang M, He X, Linford NJ, Hoddinott MP, Hopfen C, Soultoukis GA, Niemeyer C, Kerr F, Pletcher SD, Ribeiro C, Partridge L. Corrigendum: A holidic medium for Drosophila melanogaster (Nature Methods (2014) 11, (100-105)) Nature Methods. 11: 971. DOI: 10.1038/Nmeth0914-971C  0.537
2013 Regan JC, Partridge L. Gender and longevity: why do men die earlier than women? Comparative and experimental evidence. Best Practice & Research. Clinical Endocrinology & Metabolism. 27: 467-79. PMID 24054925 DOI: 10.1016/j.beem.2013.05.016  0.708
2013 Metaxakis A, Partridge L. Dietary restriction extends lifespan in wild-derived populations of Drosophila melanogaster. Plos One. 8: e74681. PMID 24040317 DOI: 10.1371/journal.pone.0074681  0.311
2013 López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell. 153: 1194-217. PMID 23746838 DOI: 10.1016/J.Cell.2013.05.039  0.382
2013 Lee SF, Eyre-Walker YC, Rane RV, Reuter C, Vinti G, Rako L, Partridge L, Hoffmann AA. Polymorphism in the neurofibromin gene, Nf1, is associated with antagonistic selection on wing size and development time in Drosophila melanogaster. Molecular Ecology. 22: 2716-25. PMID 23506114 DOI: 10.1111/Mec.12301  0.423
2013 Gems D, Partridge L. Genetics of longevity in model organisms: debates and paradigm shifts. Annual Review of Physiology. 75: 621-44. PMID 23190075 DOI: 10.1146/annurev-physiol-030212-183712  0.408
2013 Piper M, Partridge L. Preparation of a holidic medium for Drosophila melanogaster Protocol Exchange. DOI: 10.1038/Protex.2013.082  0.635
2013 Slack C, Partridge L. Genes, pathways and metabolism in ageing Drug Discovery Today: Disease Models. 10: e87-e93. DOI: 10.1016/j.ddmod.2013.01.002  0.404
2012 Partridge L. Diet and healthy aging. The New England Journal of Medicine. 367: 2550-1. PMID 23268671 DOI: 10.1056/NEJMcibr1210447  0.308
2012 Papatheodorou I, Ziehm M, Wieser D, Alic N, Partridge L, Thornton JM. Using answer set programming to integrate RNA expression with signalling pathway information to infer how mutations affect ageing. Plos One. 7: e50881. PMID 23251396 DOI: 10.1371/Journal.Pone.0050881  0.71
2012 Slack C, Foley A, Partridge L. Activation of AMPK by the putative dietary restriction mimetic metformin is insufficient to extend lifespan in Drosophila. Plos One. 7: e47699. PMID 23077661 DOI: 10.1371/journal.pone.0047699  0.757
2012 Alic N, Hoddinott MP, Foley A, Slack C, Piper MD, Partridge L. Detrimental effects of RNAi: a cautionary note on its use in Drosophila ageing studies. Plos One. 7: e45367. PMID 23028964 DOI: 10.1371/Journal.Pone.0045367  0.799
2012 Gioti A, Wigby S, Wertheim B, Schuster E, Martinez P, Pennington CJ, Partridge L, Chapman T. Sex peptide of Drosophila melanogaster males is a global regulator of reproductive processes in females. Proceedings. Biological Sciences / the Royal Society. 279: 4423-32. PMID 22977156 DOI: 10.1098/Rspb.2012.1634  0.73
2012 Niccoli T, Partridge L. Ageing as a risk factor for disease. Current Biology : Cb. 22: R741-52. PMID 22975005 DOI: 10.1016/j.cub.2012.07.024  0.399
2012 Rogers I, Kerr F, Martinez P, Hardy J, Lovestone S, Partridge L. Ageing increases vulnerability to aβ42 toxicity in Drosophila. Plos One. 7: e40569. PMID 22808195 DOI: 10.1371/Journal.Pone.0040569  0.345
2012 Barzilai N, Guarente L, Kirkwood TB, Partridge L, Rando TA, Slagboom PE. The place of genetics in ageing research. Nature Reviews. Genetics. 13: 589-94. PMID 22777128 DOI: 10.1038/Nrg3290  0.346
2012 Chen Y, Lee SF, Blanc E, Reuter C, Wertheim B, Martinez-Diaz P, Hoffmann AA, Partridge L. Genome-wide transcription analysis of clinal genetic variation in Drosophila. Plos One. 7: e34620. PMID 22514645 DOI: 10.1371/Journal.Pone.0034620  0.458
2012 Selman C, Partridge L. A double whammy for aging? Rapamycin extends lifespan and inhibits cancer in inbred female mice. Cell Cycle (Georgetown, Tex.). 11: 17-8. PMID 22186783 DOI: 10.4161/cc.11.1.18736  0.315
2012 Kerr F, Rogers I, Martinez P, Hardy J, Lovestone S, Partridge L. Ageing increases vulnerability to Aβ42 toxicity in drosophila Alzheimers & Dementia. 8: 202. DOI: 10.1016/J.Jalz.2012.05.554  0.334
2012 Partridge L. Nutrient Sensing Pathways and Ageing Free Radical Biology and Medicine. 53: S3. DOI: 10.1016/j.freeradbiomed.2012.08.073  0.361
2011 Burnett C, Valentini S, Cabreiro F, Goss M, Somogyvári M, Piper MD, Hoddinott M, Sutphin GL, Leko V, McElwee JJ, Vazquez-Manrique RP, Orfila AM, Ackerman D, Au C, Vinti G, ... ... Partridge L, et al. Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. Nature. 477: 482-5. PMID 21938067 DOI: 10.1038/Nature10296  0.701
2011 Alic N, Partridge L. Death and dessert: nutrient signalling pathways and ageing. Current Opinion in Cell Biology. 23: 738-43. PMID 21835601 DOI: 10.1016/J.Ceb.2011.07.006  0.725
2011 Piper MD, Partridge L, Raubenheimer D, Simpson SJ. Dietary restriction and aging: a unifying perspective. Cell Metabolism. 14: 154-60. PMID 21803286 DOI: 10.1016/J.Cmet.2011.06.013  0.711
2011 Alic N, Andrews TD, Giannakou ME, Papatheodorou I, Slack C, Hoddinott MP, Cochemé HM, Schuster EF, Thornton JM, Partridge L. Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling. Molecular Systems Biology. 7: 502. PMID 21694719 DOI: 10.1038/Msb.2011.36  0.797
2011 Slack C, Giannakou ME, Foley A, Goss M, Partridge L. dFOXO-independent effects of reduced insulin-like signaling in Drosophila. Aging Cell. 10: 735-48. PMID 21443682 DOI: 10.1111/j.1474-9726.2011.00707.x  0.764
2011 Bjedov I, Partridge L. A longer and healthier life with TOR down-regulation: genetics and drugs. Biochemical Society Transactions. 39: 460-5. PMID 21428920 DOI: 10.1042/Bst0390460  0.755
2011 Lee SF, Chen Y, Varan AK, Wee CW, Rako L, Axford JK, Good RT, Blacket MJ, Reuter C, Partridge L, Hoffmann AA. Molecular basis of adaptive shift in body size in Drosophila melanogaster: functional and sequence analyses of the Dca gene. Molecular Biology and Evolution. 28: 2393-402. PMID 21393605 DOI: 10.1093/Molbev/Msr064  0.453
2011 Selman C, Partridge L, Withers DJ. Replication of extended lifespan phenotype in mice with deletion of insulin receptor substrate 1. Plos One. 6: e16144. PMID 21283571 DOI: 10.1371/journal.pone.0016144  0.357
2011 Partridge L, Thornton J, Bates G. The new science of ageing. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 366: 6-8. PMID 21115524 DOI: 10.1098/Rstb.2010.0298  0.328
2011 Alic N, Hoddinott MP, Vinti G, Partridge L. Lifespan extension by increased expression of the Drosophila homologue of the IGFBP7 tumour suppressor. Aging Cell. 10: 137-47. PMID 21108726 DOI: 10.1111/J.1474-9726.2010.00653.X  0.712
2011 Partridge L. Some highlights of research on aging with invertebrates, 2010. Aging Cell. 10: 5-9. PMID 21078113 DOI: 10.1111/j.1474-9726.2010.00649.x  0.426
2011 Partridge L, Alic N, Bjedov I, Piper MD. Ageing in Drosophila: the role of the insulin/Igf and TOR signalling network. Experimental Gerontology. 46: 376-81. PMID 20849947 DOI: 10.1016/J.Exger.2010.09.003  0.816
2011 Wigby S, Slack C, Grönke S, Martinez P, Calboli FC, Chapman T, Partridge L. Insulin signalling regulates remating in female Drosophila. Proceedings. Biological Sciences / the Royal Society. 278: 424-31. PMID 20739318 DOI: 10.1098/Rspb.2010.1390  0.808
2011 Kerr F, Augustin H, Piper MD, Gandy C, Allen MJ, Lovestone S, Partridge L. Dietary restriction delays aging, but not neuronal dysfunction, in Drosophila models of Alzheimer's disease. Neurobiology of Aging. 32: 1977-89. PMID 19969390 DOI: 10.1016/J.Neurobiolaging.2009.10.015  0.692
2011 Ostler EL, Iqbal A, Faragher RG, Naughton D, Piper M, Partridge L. Chemical analysis of aging: testing predictions from green theory F1000research. 2. DOI: 10.7490/F1000Research.1743.1  0.7
2010 Fontana L, Partridge L, Longo VD. Extending healthy life span--from yeast to humans. Science (New York, N.Y.). 328: 321-6. PMID 20395504 DOI: 10.1126/science.1172539  0.394
2010 Jacobson J, Lambert AJ, Portero-Otín M, Pamplona R, Magwere T, Miwa S, Driege Y, Brand MD, Partridge L. Biomarkers of aging in Drosophila. Aging Cell. 9: 466-77. PMID 20367621 DOI: 10.1111/J.1474-9726.2010.00573.X  0.344
2010 Piper MD, Wong R, Grandison RC, Bass TM, Martinez PM, Partridge L. Water-independent effects of dietary restriction in Drosophila. Proceedings of the National Academy of Sciences of the United States of America. 107: E54-6; author reply . PMID 20363961 DOI: 10.1073/Pnas.0914686107  0.667
2010 Slack C, Werz C, Wieser D, Alic N, Foley A, Stocker H, Withers DJ, Thornton JM, Hafen E, Partridge L. Regulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, Lnk. Plos Genetics. 6: e1000881. PMID 20333234 DOI: 10.1371/Journal.Pgen.1000881  0.805
2010 Grönke S, Clarke DF, Broughton S, Andrews TD, Partridge L. Molecular evolution and functional characterization of Drosophila insulin-like peptides. Plos Genetics. 6: e1000857. PMID 20195512 DOI: 10.1371/journal.pgen.1000857  0.385
2010 Broughton SJ, Slack C, Alic N, Metaxakis A, Bass TM, Driege Y, Partridge L. DILP-producing median neurosecretory cells in the Drosophila brain mediate the response of lifespan to nutrition. Aging Cell. 9: 336-46. PMID 20156206 DOI: 10.1111/J.1474-9726.2010.00558.X  0.8
2010 Bjedov I, Toivonen JM, Kerr F, Slack C, Jacobson J, Foley A, Partridge L. Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster. Cell Metabolism. 11: 35-46. PMID 20074526 DOI: 10.1016/J.Cmet.2009.11.010  0.802
2010 Partridge L. The new biology of ageing. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 365: 147-54. PMID 20008392 DOI: 10.1098/rstb.2009.0222  0.376
2010 Partridge L, Harvey PH. The ecological context of life history evolution. Science (New York, N.Y.). 241: 1449-55. PMID 17790040 DOI: 10.1126/science.241.4872.1449  0.336
2009 Slaidina M, Delanoue R, Gronke S, Partridge L, Léopold P. A Drosophila insulin-like peptide promotes growth during nonfeeding states. Developmental Cell. 17: 874-84. PMID 20059956 DOI: 10.1016/j.devcel.2009.10.009  0.357
2009 Grandison RC, Piper MD, Partridge L. Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila. Nature. 462: 1061-4. PMID 19956092 DOI: 10.1038/Nature08619  0.694
2009 Selman C, Tullet JM, Wieser D, Irvine E, Lingard SJ, Choudhury AI, Claret M, Al-Qassab H, Carmignac D, Ramadani F, Woods A, Robinson IC, Schuster E, Batterham RL, Kozma SC, ... ... Partridge L, et al. Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science (New York, N.Y.). 326: 140-4. PMID 19797661 DOI: 10.1126/Science.1177221  0.386
2009 Ikeya T, Broughton S, Alic N, Grandison R, Partridge L. The endosymbiont Wolbachia increases insulin/IGF-like signalling in Drosophila. Proceedings. Biological Sciences / the Royal Society. 276: 3799-807. PMID 19692410 DOI: 10.1098/Rspb.2009.0778  0.711
2009 Iqbal A, Piper M, Faragher RG, Naughton DP, Partridge L, Ostler EL. Chemical changes in aging Drosophila melanogaster. Age (Dordrecht, Netherlands). 31: 343-51. PMID 19585275 DOI: 10.1007/S11357-009-9105-4  0.693
2009 Wong R, Piper MD, Wertheim B, Partridge L. Quantification of food intake in Drosophila. Plos One. 4: e6063. PMID 19557170 DOI: 10.1371/Journal.Pone.0006063  0.658
2009 Humphrey DM, Toivonen JM, Giannakou M, Partridge L, Brand MD. Expression of human uncoupling protein-3 in Drosophila insulin-producing cells increases insulin-like peptide (DILP) levels and shortens lifespan. Experimental Gerontology. 44: 316-27. PMID 19385039 DOI: 10.1016/J.Exger.2009.02.001  0.31
2009 Broughton S, Partridge L. Insulin/IGF-like signalling, the central nervous system and aging. The Biochemical Journal. 418: 1-12. PMID 19159343 DOI: 10.1042/BJ20082102  0.391
2009 Grandison RC, Wong R, Bass TM, Partridge L, Piper MD. Effect of a standardised dietary restriction protocol on multiple laboratory strains of Drosophila melanogaster. Plos One. 4: e4067. PMID 19119322 DOI: 10.1371/Journal.Pone.0004067  0.682
2009 Toivonen JM, Partridge L. Endocrine regulation of aging and reproduction in Drosophila. Molecular and Cellular Endocrinology. 299: 39-50. PMID 18682271 DOI: 10.1016/j.mce.2008.07.005  0.432
2008 Broughton S, Alic N, Slack C, Bass T, Ikeya T, Vinti G, Tommasi AM, Driege Y, Hafen E, Partridge L. Reduction of DILP2 in Drosophila triages a metabolic phenotype from lifespan revealing redundancy and compensation among DILPs. Plos One. 3: e3721. PMID 19005568 DOI: 10.1371/Journal.Pone.0003721  0.803
2008 Alic N, Partridge L. Stage debut for the elusive Drosophila insulin-like growth factor binding protein. Journal of Biology. 7: 18. PMID 18620552 DOI: 10.1186/Jbiol79  0.681
2008 Barnes AI, Wigby S, Boone JM, Partridge L, Chapman T. Feeding, fecundity and lifespan in female Drosophila melanogaster. Proceedings. Biological Sciences / the Royal Society. 275: 1675-83. PMID 18430646 DOI: 10.1098/Rspb.2008.0139  0.728
2008 Partridge L, Brüning JC. Forkhead transcription factors and ageing Oncogene. 27: 2351-2363. PMID 18391977 DOI: 10.1038/onc.2008.28  0.394
2008 Murphy MP, Partridge L. Toward a control theory analysis of aging. Annual Review of Biochemistry. 77: 777-98. PMID 18318658 DOI: 10.1146/annurev.biochem.77.070606.101605  0.354
2008 Wong R, Piper MD, Blanc E, Partridge L. Pitfalls of measuring feeding rate in the fruit fly Drosophila melanogaster. Nature Methods. 5: 214-5; author reply . PMID 18309307 DOI: 10.1038/Nmeth0308-214  0.651
2008 Giannakou ME, Goss M, Partridge L. Role of dFOXO in lifespan extension by dietary restriction in Drosophila melanogaster: not required, but its activity modulates the response. Aging Cell. 7: 187-98. PMID 18241326 DOI: 10.1111/j.1474-9726.2007.00362.x  0.381
2008 Piper MD, Selman C, McElwee JJ, Partridge L. Separating cause from effect: how does insulin/IGF signalling control lifespan in worms, flies and mice? Journal of Internal Medicine. 263: 179-91. PMID 18226095 DOI: 10.1111/J.1365-2796.2007.01906.X  0.715
2008 Selman C, Lingard S, Choudhury AI, Batterham RL, Claret M, Clements M, Ramadani F, Okkenhaug K, Schuster E, Blanc E, Piper MD, Al-Qassab H, Speakman JR, Carmignac D, Robinson IC, ... ... Partridge L, et al. Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 807-18. PMID 17928362 DOI: 10.1096/Fj.07-9261Com  0.71
2008 Butler RN, Miller RA, Perry D, Carnes BA, Williams TF, Cassel C, Brody J, Bernard MA, Partridge L, Kirkwood T, Martin GM, Olshansky SJ. Turn back time Bmj. 337: 810352. DOI: 10.1136/Sbmj.0810352  0.307
2007 Pletcher SD, Kabil H, Partridge L. Chemical Complexity and the Genetics of Aging. Annual Review of Ecology, Evolution, and Systematics. 38: 299-326. PMID 25685107 DOI: 10.1146/annurev.ecolsys.38.091206.095634  0.603
2007 Partridge L, Gems D. Benchmarks for ageing studies. Nature. 450: 165-7. PMID 17994065 DOI: 10.1038/450165a  0.352
2007 Bass TM, Grandison RC, Wong R, Martinez P, Partridge L, Piper MD. Optimization of dietary restriction protocols in Drosophila. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 62: 1071-81. PMID 17921418 DOI: 10.1093/Gerona/62.10.1071  0.674
2007 Bass TM, Weinkove D, Houthoofd K, Gems D, Partridge L. Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans. Mechanisms of Ageing and Development. 128: 546-52. PMID 17875315 DOI: 10.1016/j.mad.2007.07.007  0.342
2007 Alic N, Partridge L. Antagonizing Methuselah to extend life span. Genome Biology. 8: 222. PMID 17764591 DOI: 10.1186/Gb-2007-8-8-222  0.675
2007 McElwee JJ, Schuster E, Blanc E, Piper MD, Thomas JH, Patel DS, Selman C, Withers DJ, Thornton JM, Partridge L, Gems D. Evolutionary conservation of regulated longevity assurance mechanisms. Genome Biology. 8: R132. PMID 17612391 DOI: 10.1186/Gb-2007-8-7-R132  0.709
2007 Kennington WJ, Hoffmann AA, Partridge L. Mapping regions within cosmopolitan inversion In(3R)Payne associated with natural variation in body size in Drosophila melanogaster. Genetics. 177: 549-56. PMID 17603103 DOI: 10.1534/Genetics.107.074336  0.423
2007 Toivonen JM, Walker GA, Martinez-Diaz P, Bjedov I, Driege Y, Jacobs HT, Gems D, Partridge L. No influence of Indy on lifespan in Drosophila after correction for genetic and cytoplasmic background effects. Plos Genetics. 3: e95. PMID 17571923 DOI: 10.1371/Journal.Pgen.0030095  0.725
2007 Giannakou ME, Goss M, Jacobson J, Vinti G, Leevers SJ, Partridge L. Dynamics of the action of dFOXO on adult mortality in Drosophila Aging Cell. 6: 429-438. PMID 17465980 DOI: 10.1111/j.1474-9726.2007.00290.x  0.386
2007 Piper MD, Partridge L. Dietary restriction in Drosophila: delayed aging or experimental artefact? Plos Genetics. 3: e57. PMID 17465680 DOI: 10.1371/Journal.Pgen.0030057  0.684
2007 Giannakou ME, Partridge L. Role of insulin-like signalling in Drosophila lifespan Trends in Biochemical Sciences. 32: 180-188. PMID 17412594 DOI: 10.1016/j.tibs.2007.02.007  0.382
2007 Piper M, Mair W, Partridge L. Comment by Matthew Piper, William Mair, Linda Partridge on Min, K.J., Flatt, T., Kulaots, I., Tatar, M. (2006) "Counting calories in Drosophila dietary restriction" Exp. Gerontology, doi:10.1016/j.exger.2006.10.009 Experimental Gerontology. 42: 253-255. PMID 17317064 DOI: 10.1016/J.Exger.2007.01.002  0.625
2007 Barnes AI, Boone JM, Partridge L, Chapman T. A functioning ovary is not required for sex peptide to reduce receptivity to mating in D. melanogaster. Journal of Insect Physiology. 53: 343-8. PMID 17303161 DOI: 10.1016/J.Jinsphys.2006.12.008  0.527
2007 Kabil H, Partridge L, Harshman LG. Superoxide dismutase activities in long-lived Drosophila melanogaster females: Chico1 genotypes and dietary dilution Biogerontology. 8: 201-208. PMID 17103233 DOI: 10.1007/s10522-006-9065-3  0.317
2007 Toivonen JM, Walker GA, Martinez-Diaz P, Bjedov I, Driege Y, Jacobs HT, Gems D, Partridge L. No influence of Indy on lifespan in Drosophila after correction for genetic and cytoplasmic background effects Plos Genetics. 3: 0973-0983. DOI: 10.1371/journal.pgen.0030095  0.685
2007 Partridge L. A singular view of ageing Nature. 447: 262-263. DOI: 10.1038/447262A  0.319
2007 Wertheim B, Milton C, Hoffmann A, Godfray C, Partridge L. Functional genomics of plastic and evolutionary responses to thermal stress Comparative Biochemistry and Physiology Part a: Molecular & Integrative Physiology. 146: S206. DOI: 10.1016/J.Cbpa.2007.01.459  0.388
2007 Partridge L. Insulin signalling, oxidative stress and aging Comparative Biochemistry and Physiology Part a: Molecular & Integrative Physiology. 146: S59-S60. DOI: 10.1016/j.cbpa.2007.01.052  0.321
2006 Selman C, Kerrison ND, Cooray A, Piper MD, Lingard SJ, Barton RH, Schuster EF, Blanc E, Gems D, Nicholson JK, Thornton JM, Partridge L, Withers DJ. Coordinated multitissue transcriptional and plasma metabonomic profiles following acute caloric restriction in mice. Physiological Genomics. 27: 187-200. PMID 16882887 DOI: 10.1152/Physiolgenomics.00084.2006  0.664
2006 Partridge L, Gems D. Beyond the evolutionary theory of ageing, from functional genomics to evo-gero Trends in Ecology and Evolution. 21: 334-340. PMID 16769434 DOI: 10.1016/j.tree.2006.02.008  0.351
2006 Barnes AI, Boone JM, Jacobson J, Partridge L, Chapman T. No extension of lifespan by ablation of germ line in Drosophila. Proceedings. Biological Sciences / the Royal Society. 273: 939-47. PMID 16627279 DOI: 10.1098/Rspb.2005.3388  0.545
2006 Kennington WJ, Partridge L, Hoffmann AA. Patterns of diversity and linkage disequilibrium within the cosmopolitan inversion In(3R)Payne in Drosophila melanogaster are indicative of coadaptation. Genetics. 172: 1655-63. PMID 16322502 DOI: 10.1534/Genetics.105.053173  0.416
2005 Wertheim B, Kraaijeveld AR, Schuster E, Blanc E, Hopkins M, Pletcher SD, Strand MR, Partridge L, Godfray HC. Genome-wide gene expression in response to parasitoid attack in Drosophila. Genome Biology. 6: R94. PMID 16277749 DOI: 10.1186/Gb-2005-6-11-R94  0.568
2005 Warner H, Anderson J, Austad S, Bergamini E, Bredesen D, Butler R, Carnes BA, Clark BF, Cristofalo V, Faulkner J, Guarente L, Harrison DE, Kirkwood T, Lithgow G, Martin G, ... ... Partridge L, et al. Science fact and the SENS agenda. What can we reasonably expect from ageing research? Embo Reports. 6: 1006-8. PMID 16264422 DOI: 10.1038/Sj.Embor.7400555  0.329
2005 Piper MDW, Skorupa D, Partridge L. Diet, metabolism and lifespan in Drosophila Experimental Gerontology. 40: 857-862. PMID 16137851 DOI: 10.1016/J.Exger.2005.06.013  0.349
2005 Mair W, Piper MD, Partridge L. Calories do not explain extension of life span by dietary restriction in Drosophila. Plos Biology. 3: e223. PMID 16000018 DOI: 10.1371/Journal.Pbio.0030223  0.68
2005 Piper MDW, Mair W, Partridge L. Counting the calories: The role of specific nutrients in extension of life span by food restriction Journals of Gerontology - Series a Biological Sciences and Medical Sciences. 60: 549-555. PMID 15972601 DOI: 10.1093/Gerona/60.5.549  0.312
2005 Partridge L, Piper MD, Mair W. Dietary restriction in Drosophila. Mechanisms of Ageing and Development. 126: 938-50. PMID 15935441 DOI: 10.1016/J.Mad.2005.03.023  0.702
2005 Richard DS, Rybczynski R, Wilson TG, Wang Y, Wayne ML, Zhou Y, Partridge L, Harshman LG. Insulin signaling is necessary for vitellogenesis in Drosophila melanogaster independent of the roles of juvenile hormone and ecdysteroids: female sterility of the chico1 insulin signaling mutation is autonomous to the ovary. Journal of Insect Physiology. 51: 455-64. PMID 15890189 DOI: 10.1016/J.Jinsphys.2004.12.013  0.352
2005 Partridge L, Gems D, Withers DJ. Sex and death: What is the connection? Cell. 120: 461-472. PMID 15734679 DOI: 10.1016/j.cell.2005.01.026  0.369
2005 Broughton SJ, Piper MD, Ikeya T, Bass TM, Jacobson J, Driege Y, Martinez P, Hafen E, Withers DJ, Leevers SJ, Partridge L. Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands. Proceedings of the National Academy of Sciences of the United States of America. 102: 3105-10. PMID 15708981 DOI: 10.1073/Pnas.0405775102  0.689
2005 Partridge L, Pletcher SD, Mair W. Dietary restriction, mortality trajectories, risk and damage. Mechanisms of Ageing and Development. 126: 35-41. PMID 15610760 DOI: 10.1016/j.mad.2004.09.017  0.582
2005 Partridge L, Brand MD. Special issue on dietary restriction: Dietary restriction, longevity and ageing - The current state of our knowledge and ignorance Mechanisms of Ageing and Development. 126: 911-912. DOI: 10.1016/J.Mad.2005.04.003  0.3
2005 Piper MDW, Selman C, McElwee JJ, Partridge L. Models of insulin signalling and longevity Drug Discovery Today: Disease Models. 2: 249-256. DOI: 10.1016/J.Ddmod.2005.11.001  0.378
2004 Giannakou ME, Partridge L. The interaction between FOXO and SIRT1: Tipping the balance towards survival Trends in Cell Biology. 14: 408-412. PMID 15308206 DOI: 10.1016/j.tcb.2004.07.006  0.31
2004 Hulbert AJ, Clancy DJ, Mair W, Braeckman BP, Gems D, Partridge L. Metabolic rate is not reduced by dietary-restriction or by lowered insulin/IGF-1 signalling and is not correlated with individual lifespan in Drosophila melanogaster. Experimental Gerontology. 39: 1137-43. PMID 15288688 DOI: 10.1016/J.Exger.2004.04.006  0.693
2004 Mair W, Sgrò CM, Johnson AP, Chapman T, Partridge L. Lifespan extension by dietary restriction in female Drosophila melanogaster is not caused by a reduction in vitellogenesis or ovarian activity. Experimental Gerontology. 39: 1011-9. PMID 15236760 DOI: 10.1016/J.Exger.2004.03.018  0.567
2004 Giannakou ME, Goss M, Jünger MA, Hafen E, Leevers SJ, Partridge L. Long-lived Drosophila with overexpressed dFOXO in adult fat body. Science (New York, N.Y.). 305: 361. PMID 15192154 DOI: 10.1126/Science.1098219  0.395
2004 Magwere T, Chapman T, Partridge L. Sex differences in the effect of dietary restriction on life span and mortality rates in female and male Drosophila melanogaster. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 59: 3-9. PMID 14718480 DOI: 10.1093/Gerona/59.1.B3  0.564
2004 Rauser CL, Mueller LD, Rose MR, Mair W, Goymer P, Pletcher SD, Partridge L. Dietary Restriction in Drosophilla [2] (multiple letters) Science. 303: 1610-1612.  0.496
2003 Hoffmann AA, Scott M, Partridge L, Hallas R. Overwintering in Drosophila melanogaster: Outdoor field cage experiments on clinal and laboratory selected populations help to elucidate traits under selection Journal of Evolutionary Biology. 16: 614-623. PMID 14632225 DOI: 10.1046/J.1420-9101.2003.00561.X  0.436
2003 Mair W, Goymer P, Pletcher SD, Partridge L. Demography of dietary restriction and death in Drosophila. Science (New York, N.Y.). 301: 1731-3. PMID 14500985 DOI: 10.1126/science.1086016  0.61
2003 Chapman T, Bangham J, Vinti G, Seifried B, Lung O, Wolfner MF, Smith HK, Partridge L. The sex peptide of Drosophila melanogaster: female post-mating responses analyzed by using RNA interference. Proceedings of the National Academy of Sciences of the United States of America. 100: 9923-8. PMID 12893873 DOI: 10.1073/Pnas.1631635100  0.519
2003 Bangham J, Chapman T, Smith HK, Partridge L. Influence of female reproductive anatomy on the outcome of sperm competition in Drosophila melanogaster. Proceedings. Biological Sciences / the Royal Society. 270: 523-30. PMID 12641908 DOI: 10.1098/Rspb.2002.2237  0.514
2002 Gems D, Pletcher S, Partridge L. Interpreting interactions between treatments that slow aging Aging Cell. 1: 1-9. PMID 12882347 DOI: 10.1046/J.1474-9728.2002.00003.X  0.607
2002 Carey JR, Liedo P, Harshman L, Zhang Y, Müller HG, Partridge L, Wang JL. Life history response of Mediterranean fruit flies to dietary restriction. Aging Cell. 1: 140-8. PMID 12882344 DOI: 10.1046/J.1474-9728.2002.00019.X  0.353
2002 Partridge L, Gems D. The evolution of longevity Current Biology : Cb. 12: R544-546. PMID 12194832 DOI: 10.1016/S0960-9822(02)01048-5  0.428
2002 Pletcher SD, Macdonald SJ, Marguerie R, Certa U, Stearns SC, Goldstein DB, Partridge L. Genome-wide transcript profiles in aging and calorically restricted Drosophila melanogaster. Current Biology : Cb. 12: 712-23. PMID 12007414 DOI: 10.1016/S0960-9822(02)00808-4  0.624
2002 Partridge L, Gems D. Mechanisms of ageing: Public or private? Nature Reviews Genetics. 3: 165-175. PMID 11972154 DOI: 10.1038/nrg753  0.372
2002 Clancy DJ, Gems D, Hafen E, Leevers SJ, Partridge L. Dietary restriction in long-lived dwarf flies. Science (New York, N.Y.). 296: 319. PMID 11951037 DOI: 10.1126/Science.1069366  0.687
2002 Carey JR, Liedo P, Harshman L, Zhang Y, Müller HG, Partridge L, Wang JL. A mortality cost of virginity at older ages in female Mediterranean fruit flies. Experimental Gerontology. 37: 507-12. PMID 11830353 DOI: 10.1016/S0531-5565(01)00230-3  0.327
2002 Carey JR, Liedo P, Harshman L, Liu X, Müller HG, Partridge L, Wang JL. Food pulses increase longevity and induce cyclical egg production in Mediterranean fruit flies Functional Ecology. 16: 313-325. DOI: 10.1046/J.1365-2435.2002.00633.X  0.306
2002 Bangham J, Chapman T, Partridge L. Effects of body size, accessory gland and testis size on pre- and postcopulatory success in Drosophila melanogaster Animal Behaviour. 64: 915-921. DOI: 10.1006/Anbe.2002.1976  0.517
2001 Partridge L. The Insulin Signaling Pathway and Aging in Drosophila. Thescientificworldjournal. 1: 76. PMID 30147550 DOI: 10.1100/tsw.2001.138  0.359
2001 Sgrò CM, Partridge L. Laboratory adaptation of life history in Drosophila. The American Naturalist. 158: 657-8. PMID 18707359 DOI: 10.1086/323592  0.543
2001 Chapman T, Herndon LA, Heifetz Y, Partridge L, Wolfner MF. The Acp26Aa seminal fluid protein is a modulator of early egg hatchability in Drosophila melanogaster. Proceedings. Biological Sciences / the Royal Society. 268: 1647-54. PMID 11506676 DOI: 10.1098/Rspb.2001.1684  0.527
2001 Gems D, Partridge L. Insulin/IGF signalling and ageing: seeing the bigger picture. Current Opinion in Genetics & Development. 11: 287-92. PMID 11377965 DOI: 10.1016/S0959-437X(00)00192-1  0.397
2001 Hoffmann AA, Hallas R, Sinclair C, Partridge L. Rapid loss of stress resistance in drosophila melanogaster under adaptation to laboratory culture Evolution. 55: 436-438. PMID 11308098 DOI: 10.1111/J.0014-3820.2001.Tb01305.X  0.424
2001 Partridge L. Evolutionary theories of ageing applied to long-lived organisms. Experimental Gerontology. 36: 641-50. PMID 11295505 DOI: 10.1016/S0531-5565(00)00232-1  0.374
2001 Clancy DJ, Gems D, Harshman LG, Oldham S, Stocker H, Hafen E, Leevers SJ, Partridge L. Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science (New York, N.Y.). 292: 104-6. PMID 11292874 DOI: 10.1126/Science.1057991  0.703
2001 Hoffmann AA, Hallas R, Sinclair C, Partridge L. RAPID LOSS OF STRESS RESISTANCE IN DROSOPHILA MELANOGASTER UNDER ADAPTATION TO LABORATORY CULTURE Evolution. 55: 436. DOI: 10.1554/0014-3820(2001)055[0436:RLOSRI]2.0.CO;2  0.311
2000 Sgrò CM, Geddes G, Fowler K, Partridge L. Selection on age at reproduction in Drosophila melanogaster: female mating frequency as a correlated response. Evolution; International Journal of Organic Evolution. 54: 2152-5. PMID 11209790 DOI: 10.1111/J.0014-3820.2000.Tb01257.X  0.594
2000 Chapman T, Neubaum DM, Wolfner MF, Partridge L. The role of male accessory gland protein Acp36DE in sperm competition in Drosophila melanogaster. Proceedings. Biological Sciences / the Royal Society. 267: 1097-105. PMID 10885514 DOI: 10.1098/Rspb.2000.1114  0.512
2000 Sgro CM, Partridge L. Evolutionary responses of the life history of wild-caught Drosophila melanogaster to two standard methods of laboratory culture American Naturalist. 156: 341-353. DOI: 10.1086/303394  0.543
1999 Miyatake T, Chapman T, Partridge L. Mating-induced inhibition of remating in female Mediterranean fruit flies Ceratitis capitata. Journal of Insect Physiology. 45: 1021-1028. PMID 12770277 DOI: 10.1016/S0022-1910(99)00083-9  0.511
1999 Sgrò CM, Partridge L. A delayed wave of death from reproduction in Drosophila. Science (New York, N.Y.). 286: 2521-4. PMID 10617470 DOI: 10.1126/Science.286.5449.2521  0.576
1999 Partridge L, Mangel M. Messages from mortality: the evolution of death rates in the old. Trends in Ecology & Evolution. 14: 438-442. PMID 10511720 DOI: 10.1016/S0169-5347(99)01646-8  0.304
1999 Partridge L, Prowse N, Pignatelli P. Another set of responses and correlated responses to selection on age at reproduction in Drosophila melanogaster. Proceedings. Biological Sciences. 266: 255-61. PMID 10081162 DOI: 10.1098/rspb.1999.0630  0.346
1998 Sgrò CM, Chapman T, Partridge L. Sex-specific selection on time to remate in Drosophila melanogaster. Animal Behaviour. 56: 1267-1278. PMID 9819344 DOI: 10.1006/Anbe.1998.0900  0.648
1998 Chapman T, Miyatake T, Smith HK, Partridge L. Interactions of mating, egg production and death rates in females of the Mediterranean fruit fly, Ceratitis capitata. Proceedings. Biological Sciences / the Royal Society. 265: 1879-94. PMID 9802244 DOI: 10.1098/Rspb.1998.0516  0.516
1998 Rogina B, Vaupel JW, Partridge L, Helfand SL. Regulation of gene expression is preserved in aging Drosophila melanogaster. Current Biology : Cb. 8: 475-8. PMID 9550706 DOI: 10.1016/S0960-9822(98)70184-8  0.352
1998 Parker GA, Partridge L. Sexual conflict and speciation. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 353: 261-74. PMID 9533125 DOI: 10.1098/rstb.1998.0208  0.309
1998 Partridge L, Sgrò CM. Behavioural genetics: molecular genetics meets feeding ecology. Current Biology : Cb. 8: R23-4. PMID 9427617 DOI: 10.1016/S0960-9822(98)70011-9  0.535
1997 McCabe J, Partridge L. AN INTERACTION BETWEEN ENVIRONMENTAL TEMPERATURE AND GENETIC VARIATION FOR BODY SIZE FOR THE FITNESS OF ADULT FEMALE DROSOPHILA MELANOGASTER. Evolution; International Journal of Organic Evolution. 51: 1164-1174. PMID 28565476 DOI: 10.1111/j.1558-5646.1997.tb03964.x  0.306
1997 Azevedo RBR, French V, Partridge L. Life-History Consequences Of Egg Size In Drosophila Melanogaster The American Naturalist. 150: 250-282. PMID 18811284 DOI: 10.1086/286065  0.301
1997 Wolfner MF, Partridge L, Lewin S, Kalb JM, Chapman T, Herndon LA. Mating and hormonal triggers regulate accessory gland gene expression in male Drosophila. Journal of Insect Physiology. 43: 1117-1123. PMID 12770484 DOI: 10.1016/S0022-1910(97)00062-0  0.521
1997 Charlesworth B, Partridge L. Ageing: levelling of the grim reaper. Current Biology : Cb. 7: R440-2. PMID 9210361 DOI: 10.1016/S0960-9822(06)00213-2  0.33
1996 Chapman T, Partridge L. Female fitness in Drosophila melanogaster: an interaction between the effect of nutrition and of encounter rate with males. Proceedings. Biological Sciences / the Royal Society. 263: 755-9. PMID 8763795 DOI: 10.1098/Rspb.1996.0113  0.537
1996 Chapman T, Partridge L. Sexual conflict as fuel for evolution. Nature. 381: 189-90. PMID 8622753 DOI: 10.1038/381189A0  0.491
1996 Partridge L, Barton NH. On measuring the rate of ageing Proceedings of the Royal Society B: Biological Sciences. 263: 1365-1371. DOI: 10.1098/Rspb.1996.0200  0.361
1996 Chapman T, Choffat Y, Lucas WE, Kubli E, Partridge L. Lack of response to sex-peptide results in increased cost of mating in dunce Drosophila melanogaster females Journal of Insect Physiology. 42: 1007-1015. DOI: 10.1016/S0022-1910(96)00070-4  0.518
1996 CORDTS R, PARTRIDGE L. Courtship reduces longevity of maleDrosophila melanogaster Animal Behaviour. 52: 269-278. DOI: 10.1006/anbe.1996.0172  0.308
1995 Chapman T, Liddle LF, Kalb JM, Wolfner MF, Partridge L. Cost of mating in Drosophila melanogaster females is mediated by male accessory gland products. Nature. 373: 241-4. PMID 7816137 DOI: 10.1038/373241A0  0.519
1994 Partridge L, Prowse N. Gerontology. Mutation, variation and the evolution of ageing. Current Biology : Cb. 4: 430-2. PMID 7922358 DOI: 10.1016/S0960-9822(00)00094-4  0.325
1994 Chapman T, Trevitt S, Partridge L. Remating and male-derived nutrients in Drosophila melanogaster Journal of Evolutionary Biology. 7: 51-69. DOI: 10.1046/J.1420-9101.1994.7010051.X  0.527
1993 Partridge L, Barton NH. Optimality, mutation and the evolution of ageing. Nature. 362: 305-11. PMID 8455716 DOI: 10.1038/362305A0  0.306
1993 Chapman T, Hutchings J, Partridge L. No reduction in the cost of mating for Drosophila melanogaster females mating with spermless males. Proceedings. Biological Sciences / the Royal Society. 253: 211-7. PMID 8234360 DOI: 10.1098/rspb.1993.0105  0.502
1993 Partridge L, Barton NH. Evolution of aging: testing the theory using Drosophila. Genetica. 91: 89-98. PMID 8125281 DOI: 10.1007/Bf01435990  0.33
1993 Partridge L. Aging, Sex and DNA Repair . By Carol Bernstein and Harni Bernstein . Academic Press. 1991. 382 pages. Price $44. ISBN 0 12 092840 4. - Genetic Effects on Aging II . Edited by D. E. Harrison. CRC Press. 1990. 573 pages. Price £50. ISBN 0 936923 318. Genetics Research. 62: 79-81. DOI: 10.1017/S0016672300031591  0.316
1992 Partridge L, Fowler K. DIRECT AND CORRELATED RESPONSES TO SELECTION ON AGE AT REPRODUCTION IN DROSOPHILA MELANOGASTER. Evolution; International Journal of Organic Evolution. 46: 76-91. PMID 28564973 DOI: 10.1111/J.1558-5646.1992.Tb01986.X  0.318
1991 Partridge L, Sibly R. Constraints in the Evolution of Life Histories Philosophical Transactions of the Royal Society B. 332: 3-13. DOI: 10.1098/Rstb.1991.0027  0.324
1991 Trevitt S, Partridge L. A cost of receiving sperm in the female fruitfly Drosophila melanogaster Journal of Insect Physiology. 37: 471-475. DOI: 10.1016/0022-1910(91)90057-7  0.301
1989 Partridge L. The rare-male effect: what is its evolutionary significance? Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 319: 525-39. PMID 2905490 DOI: 10.1098/RSTB.1988.0063  0.315
1989 Fowler K, Partridge L. A cost of mating in female fruitflies Nature. 338: 760-761. DOI: 10.1038/338760A0  0.333
1988 Steele RH, Partridge L. A courtship advantage for small males in Drosophila subobscura Animal Behaviour. 36: 1190-1197. DOI: 10.1016/S0003-3472(88)80078-2  0.303
1987 Partridge L. Is accelerated senescence a cost of reproduction Functional Ecology. 1: 317-320. DOI: 10.2307/2389786  0.378
1987 Partridge L, Hoffmann A, Jones J. Male size and mating success in Drosophila melanogaster and D. pseudoobscura under field conditions Animal Behaviour. 35: 468-476. DOI: 10.1016/S0003-3472(87)80272-5  0.451
1987 Partridge L, Green A, Fowler K. Effects of egg-production and of exposure to males on female survival in Drosophila melanogaster Journal of Insect Physiology. 33: 745-749. DOI: 10.1016/0022-1910(87)90060-6  0.309
1986 Fowler K, Partridge L. Variation in male fertility explains an apparent effect of genotypic diversity on success in larval competition in Drosophila melanogaster Heredity. 57: 31-36. DOI: 10.1038/Hdy.1986.83  0.313
1986 Partridge L, Fowler K, Trevitt S, Sharp W. An examination of the effects of males on the survival and egg-production rates of female Drosophila melanogaster Journal of Insect Physiology. 32: 925-929. DOI: 10.1016/0022-1910(86)90140-X  0.311
1985 Partridge L, Andrews R. The effect of reproductive activity on the longevity of male Drosophila melanogaster is not caused by an acceleration of ageing Journal of Insect Physiology. 31: 393-395. DOI: 10.1016/0022-1910(85)90084-8  0.365
1983 Partridge L, Farquhar M. Lifetime mating success of male fruitflies (Drosophila melanogaster) is related to their size Animal Behaviour. 31: 871-877. DOI: 10.1016/S0003-3472(83)80242-5  0.311
1981 PARTRIDGE L. Does mate choice occur in Drosophila melanogaster? (reply) Nature. 293: 492-492. DOI: 10.1038/293492B0  0.307
1980 Partridge L. Mate choice increases a component of offspring fitness in fruit flies Nature. 283: 290-291. DOI: 10.1038/283290A0  0.314
Low-probability matches (unlikely to be authored by this person)
2008 Gems D, Partridge L. Stress-response hormesis and aging: "that which does not kill us makes us stronger". Cell Metabolism. 7: 200-3. PMID 18316025 DOI: 10.1016/j.cmet.2008.01.001  0.299
2006 Magwere T, West M, Riyahi K, Murphy MP, Smith RA, Partridge L. The effects of exogenous antioxidants on lifespan and oxidative stress resistance in Drosophila melanogaster. Mechanisms of Ageing and Development. 127: 356-70. PMID 16442589 DOI: 10.1016/j.mad.2005.12.009  0.299
1992 Stamenkovic-Radak M, Partridge L, Andjelkovic M. A genetic correlation between the sexes for mating speed in Drosophila melanogaster Animal Behaviour. 43: 389-396. DOI: 10.1016/S0003-3472(05)80099-5  0.298
2016 Ding X, Bloch W, Iden S, Rüegg MA, Hall MN, Leptin M, Partridge L, Eming SA. mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation. Nature Communications. 7: 13226. PMID 27807348 DOI: 10.1038/ncomms13226  0.298
1988 Trevitt S, Fowler K, Partridge L. An effect of egg-deposition on the subsequent fertility and remating frequency of female Drosophila melanogaster Journal of Insect Physiology. 34: 821-828. DOI: 10.1016/0022-1910(88)90157-6  0.297
1987 Bownes M, Partridge L. Transfer of molecules from ejaculate to females in Drosophila melanogaster and Drosophila pseudoobscura Journal of Insect Physiology. 33: 941-947. DOI: 10.1016/0022-1910(87)90006-0  0.297
1990 Partridge L, Fowler K. Non-mating costs of exposure to males in female Drosophila melanogaster Journal of Insect Physiology. 36: 419-425. DOI: 10.1016/0022-1910(90)90059-O  0.296
2009 Augustin H, Partridge L. Invertebrate models of age-related muscle degeneration. Biochimica Et Biophysica Acta. 1790: 1084-94. PMID 19563864 DOI: 10.1016/J.Bbagen.2009.06.011  0.295
2010 Fontana L, Partridge L. Dietary restriction: Standing up for sirtuins - Response Science. 329: 1013. DOI: 10.1126/Science.329.5995.1013-A  0.294
1981 Partridge L, Farquhar M. Sexual activity reduces lifespan of male fruitflies Nature. 294: 580-582. DOI: 10.1038/294580a0  0.294
1997 Gilchrist AS, Partridge L. Heritability of pre-adult viability differences can explain apparent heritability of sperm displacement ability in Drosophila melanogaster. Proceedings. Biological Sciences / the Royal Society. 264: 1271-5. PMID 9332012 DOI: 10.1098/rspb.1997.0175  0.294
2013 Wredenberg A, Lagouge M, Bratic A, Metodiev MD, Spåhr H, Mourier A, Freyer C, Ruzzenente B, Tain L, Grönke S, Baggio F, Kukat C, Kremmer E, Wibom R, Polosa PL, ... ... Partridge L, et al. MTERF3 regulates mitochondrial ribosome biogenesis in invertebrates and mammals. Plos Genetics. 9: e1003178. PMID 23300484 DOI: 10.1371/journal.pgen.1003178  0.293
1998 Partridge L, Hurst LD. Sex and conflict. Science (New York, N.Y.). 281: 2003-8. PMID 9748155 DOI: 10.1126/science.281.5385.2003  0.293
2000 Gilchrist AS, Partridge L. Why it is difficult to model sperm displacement in Drosophila melanogaster: the relation between sperm transfer and copulation duration. Evolution; International Journal of Organic Evolution. 54: 534-42. PMID 10937230 DOI: 10.1111/j.0014-3820.2000.tb00056.x  0.292
2017 Brandt T, Mourier A, Tain LS, Partridge L, Larsson N, Kühlbrandt W. Author response: Changes of mitochondrial ultrastructure and function during ageing in mice and Drosophila Elife. DOI: 10.7554/Elife.24662.018  0.292
2019 Moens TG, Niccoli T, Wilson KM, Atilano ML, Birsa N, Gittings LM, Holbling BV, Dyson MC, Thoeng A, Neeves J, Glaria I, Yu L, Bussmann J, Storkebaum E, Pardo M, ... ... Partridge L, et al. C9orf72 arginine-rich dipeptide proteins interact with ribosomal proteins in vivo to induce a toxic translational arrest that is rescued by eIF1A. Acta Neuropathologica. PMID 30604225 DOI: 10.1007/s00401-018-1946-4  0.29
2006 Partridge L. Of worms, mice & men: Altering rates of aging Daedalus. 135: 40-47. DOI: 10.1162/001152606775321013  0.29
2008 Selman C, Lingard S, Gems D, Partridge L, Withers DJ. Comment on "Brain IRS2 signaling coordinates life span and nutrient homeostasis". Science (New York, N.Y.). 320: 1012; author reply 1. PMID 18497277 DOI: 10.1126/science.1152366  0.29
1998 Currie DB, Mackay TF, Partridge L. Pervasive effects of P element mutagenesis on body size in Drosophila melanogaster. Genetical Research. 72: 19-24. PMID 9802259 DOI: 10.1017/S0016672398003383  0.29
2015 Knuever J, Willenborg S, Ding X, Akyüz MD, Partridge L, Niessen CM, Brüning JC, Eming SA. Myeloid Cell-Restricted Insulin/IGF-1 Receptor Deficiency Protects against Skin Inflammation. Journal of Immunology (Baltimore, Md. : 1950). PMID 26519530 DOI: 10.4049/jimmunol.1501237  0.29
1984 PARTRIDGE L, HILL WG. Mechanisms for frequency-dependent mating success Biological Journal of the Linnean Society. 23: 113-132. DOI: 10.1111/J.1095-8312.1984.TB00132.X  0.29
2003 Calboli FCF, Gilchrist GW, Partridge L. Different cell size and cell number contribution in two newly established and one ancient body size cline of Drosophila subobscura Evolution. 57: 566-573. PMID 12703946 DOI: 10.1111/J.0014-3820.2003.Tb01548.X  0.29
1993 Roper C, Pignatelli P, Partridge L. EVOLUTIONARY EFFECTS OF SELECTION ON AGE AT REPRODUCTION IN LARVAL AND ADULT: DROSOPHILA MELANOGASTER. Evolution; International Journal of Organic Evolution. 47: 445-455. PMID 28568728 DOI: 10.1111/j.1558-5646.1993.tb02105.x  0.289
1994 Santos M, Fowler K, Partridge L. Gene-environment interaction for body size and larval density in Drosophila melanogaster: an investigation of effects on development time, thorax length and adult sex ratio. Heredity. 515-21. PMID 8014062 DOI: 10.1038/Hdy.1994.69  0.288
1996 Roper C, Pignatelli P, Partridge L. Evolutionary responses of Drosophila melanogaster life history to differences in larval density Journal of Evolutionary Biology. 9: 609-622. DOI: 10.1046/j.1420-9101.1996.9050609.x  0.288
2014 Metaxakis A, Tain LS, Grönke S, Hendrich O, Hinze Y, Birras U, Partridge L. Lowered insulin signalling ameliorates age-related sleep fragmentation in Drosophila. Plos Biology. 12: e1001824. PMID 24690889 DOI: 10.1371/journal.pbio.1001824  0.288
2008 Kerr F, Partridge L. P1-066: Dietary restriction delays ageing, but not neuronal pathology, in drosophila models of Alzheimer's disease Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.652  0.288
2017 Kerr F, Sofola-Adesakin O, Ivanov DK, Gatliff J, Gomez Perez-Nievas B, Bertrand HC, Martinez P, Callard R, Snoeren I, Cochemé HM, Adcott J, Khericha M, Castillo-Quan JI, Wells G, Noble W, ... ... Partridge L, et al. Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer's disease. Plos Genetics. 13: e1006593. PMID 28253260 DOI: 10.1371/Journal.Pgen.1006593  0.287
2004 Miwa S, Riyahi K, Partridge L, Brand MD. Lack of correlation between mitochondrial reactive oxygen species production and life span in Drosophila Annals of the New York Academy of Sciences. 1019: 388-391. PMID 15247051 DOI: 10.1196/Annals.1297.069  0.286
2017 Zhao Y, Gilliat AF, Ziehm M, Turmaine M, Wang H, Ezcurra M, Yang C, Phillips G, McBay D, Zhang WB, Partridge L, Pincus Z, Gems D. Two forms of death in ageing Caenorhabditis elegans. Nature Communications. 8: 15458. PMID 28534519 DOI: 10.1038/Ncomms15458  0.286
2009 Toivonen JM, Gems D, Partridge L. Longevity of Indy mutant Drosophila not attributable to Indy mutation. Proceedings of the National Academy of Sciences of the United States of America. 106: E53; author reply E5. PMID 19435842 DOI: 10.1073/pnas.0902462106  0.285
2016 Balendra R, Mizielinska S, Moens T, Niccoli T, Ridler C, Simone R, Woodling N, Parkinson G, Neidle S, Patani R, Partridge L, Isaacs A. Molecular mechanisms and therapeutic strategies in amyotrophic lateral sclerosis caused by C9orf72 mutations The Lancet. 387. DOI: 10.1016/S0140-6736(16)00400-1  0.284
1987 Partridge L, Ewing A, Chandler A. Male size and mating success in Drosophila melanogaster: the roles of male and female behaviour Animal Behaviour. 35: 555-562. DOI: 10.1016/S0003-3472(87)80281-6  0.283
1995 Gilchrist A, Partridge L. Male identity and sperm displacement in Drosophila melanogaster Journal of Insect Physiology. 41: 1087-1092. DOI: 10.1016/0022-1910(95)00068-6  0.283
1993 Stamencovic-Radak M, Partridge L, Andjelcovic M. Genetic correlation between the sexes in Drosophila melanogaster: a reply to Butlin Animal Behaviour. 45: 405. DOI: 10.1006/Anbe.1993.1047  0.282
2000 Zwaan BJ, Azevedo RB, James AC, Van 't Land J, Partridge L. Cellular basis of wing size variation in Drosophila melanogaster: a comparison of latitudinal clines on two continents Heredity. 84. PMID 10762404 DOI: 10.1046/J.1365-2540.2000.00677.X  0.282
2019 Robinson SJW, Partridge L. Temperature and clinal variation in larval growth efficiency in Drosophila melanogaster. Journal of Evolutionary Biology. 14: 14-21. PMID 29280588 DOI: 10.1046/j.1420-9101.2001.00259.x  0.282
1984 Harvey PH, Partridge L. When deviants are favoured: evolution of sex determination. Nature. 307: 689-91. PMID 6700699 DOI: 10.1038/307689A0  0.281
1996 Partridge L. Ageing: A biomedical perspective: by D. Bellamy Wiley, 1995. £39.95 hbk (i + 410 pages) ISBN 0 471 92067 3 Trends in Ecology and Evolution. 11: 264. DOI: 10.1016/0169-5347(96)91638-9  0.281
1985 Partridge L, Mackay TFC, Aitken S. Male mating success and fertility in Drosophila melanogaster Genetical Research. 46: 279-285. DOI: 10.1017/S0016672300022783  0.28
1995 Neat F, Fowler K, French V, Partridge L. Thermal evolution of growth efficiency in Drosophila melanogaster. Proceedings. Biological Sciences. 260: 73-8. PMID 7761485 DOI: 10.1098/Rspb.1995.0061  0.28
2006 Magwere T, Pamplona R, Miwa S, Martinez-Diaz P, Portero-Otin M, Brand MD, Partridge L. Flight activity, mortality rates, and lipoxidative damage in Drosophila Journals of Gerontology - Series a Biological Sciences and Medical Sciences. 61: 136-145. PMID 16510857 DOI: 10.1093/Gerona/61.2.136  0.28
2001 Robinson SJ, Zwaan B, Partridge L. Starvation resistance and adult body composition in a latitudinal cline of Drosophila melanogaster. Evolution; International Journal of Organic Evolution. 54: 1819-24. PMID 11108609 DOI: 10.1111/j.0014-3820.2000.tb00726.x  0.279
2001 Kennington WJ, Gilchrist AS, Goldstein DB, Partridge L. The genetic bases of divergence in desiccation and starvation resistance among tropical and temperate populations of Drosophila melanogaster. Heredity. 87: 363-72. PMID 11737283 DOI: 10.1046/j.1365-2540.2001.00925.x  0.279
2021 Tain LS, Sehlke R, Meilenbrock RL, Leech T, Paulitz J, Chokkalingam M, Nagaraj N, Grönke S, Fröhlich J, Atanassov I, Mann M, Beyer A, Partridge L. Tissue-specific modulation of gene expression in response to lowered insulin signalling in . Elife. 10. PMID 33879316 DOI: 10.7554/eLife.67275  0.277
1981 Partridge L. Increased preferences for familiar foods in small mammals Animal Behaviour. 29: 211-216. DOI: 10.1016/S0003-3472(81)80168-6  0.277
2011 Bratic A, Wredenberg A, Grönke S, Stewart JB, Mourier A, Ruzzenente B, Kukat C, Wibom R, Habermann B, Partridge L, Larsson NG. The bicoid stability factor controls polyadenylation and expression of specific mitochondrial mRNAs in Drosophila melanogaster. Plos Genetics. 7: e1002324. PMID 22022283 DOI: 10.1371/journal.pgen.1002324  0.276
2010 Sofola O, Kerr F, Rogers I, Killick R, Augustin H, Gandy C, Allen MJ, Hardy J, Lovestone S, Partridge L. Inhibition of GSK-3 ameliorates Abeta pathology in an adult-onset Drosophila model of Alzheimer's disease. Plos Genetics. 6: e1001087. PMID 20824130 DOI: 10.1371/Journal.Pgen.1001087  0.276
2017 Moens TG, Partridge L, Isaacs AM. Genetic models of C9orf72: what is toxic? Current Opinion in Genetics & Development. 44: 92-101. PMID 28364657 DOI: 10.1016/j.gde.2017.01.006  0.276
2016 Niccoli T, Cabecinha M, Tillmann A, Kerr F, Wong CT, Cardenes D, Vincent AJ, Bettedi L, Li L, Grönke S, Dols J, Partridge L. Increased Glucose Transport into Neurons Rescues Aβ Toxicity in Drosophila. Current Biology : Cb. PMID 27524482 DOI: 10.1016/j.cub.2016.07.017  0.275
1998 Azevedo RBR, James AC, McCabe J, Partridge L. LATITUDINAL VARIATION OF WING:THORAX SIZE RATIO AND WING-ASPECT RATIO IN DROSOPHILA MELANOGASTER. Evolution; International Journal of Organic Evolution. 52: 1353-1362. PMID 28565379 DOI: 10.1111/j.1558-5646.1998.tb02017.x  0.274
1999 Partridge L, Langelan R, Fowler K, Zwaan B, French V. Correlated responses to selection on body size in Drosophila melanogaster. Genetical Research. 74: 43-54. PMID 10505406 DOI: 10.1017/S0016672399003778  0.273
2000 Gilchrist AS, Azevedo RB, Partridge L, O'Higgins P. Adaptation and constraint in the evolution of Drosophila melanogaster wing shape. Evolution & Development. 2: 114-24. PMID 11258389 DOI: 10.1046/J.1525-142X.2000.00041.X  0.272
2020 Kakanj P, Eming SA, Partridge L, Leptin M. Long-term in vivo imaging of Drosophila larvae. Nature Protocols. PMID 32042177 DOI: 10.1038/s41596-019-0282-z  0.272
2019 French V, Feast M, Partridge L. Body size and cell size in Drosophila: the developmental response to temperature. Journal of Insect Physiology. 44: 1081-1089. PMID 12770407 DOI: 10.1016/S0022-1910(98)00061-4  0.272
2014 Baggio F, Bratic A, Mourier A, Kauppila TE, Tain LS, Kukat C, Habermann B, Partridge L, Larsson NG. Drosophila melanogaster LRPPRC2 is involved in coordination of mitochondrial translation. Nucleic Acids Research. 42: 13920-38. PMID 25428350 DOI: 10.1093/nar/gku1132  0.271
2001 Ackermann M, Bijlsma R, James AC, Partridge L, Zwaan BJ, Stearns SC. Effects of assay conditions in life history experiments with Drosophila melanogaster Journal of Evolutionary Biology. 14: 199-209. DOI: 10.1046/J.1420-9101.2001.00281.X  0.271
1983 Partridge L, Gardner A. Failure to Replicate the Results of an Experiment on the Rare Male Effect in Drosophila menlanogaster The American Naturalist. 122: 422-427. DOI: 10.1086/284145  0.271
2001 Gilchrist AS, Partridge L. The contrasting genetic architecture of wing size and shape in Drosophila melanogaster. Heredity. 86: 144-52. PMID 11380659 DOI: 10.1046/J.1365-2540.2001.00779.X  0.27
2012 Neuhaus B, Niessen CM, Mesaros A, Withers DJ, Krieg T, Partridge L. Experimental analysis of risk factors for ulcerative dermatitis in mice. Experimental Dermatology. 21: 712-3. PMID 22897579 DOI: 10.1111/j.1600-0625.2012.01558.x  0.27
1994 Partridge L, Barrie B, Fowler K, French V. EVOLUTION AND DEVELOPMENT OF BODY SIZE AND CELL SIZE IN DROSOPHILA MELANOGASTER IN RESPONSE TO TEMPERATURE. Evolution; International Journal of Organic Evolution. 48: 1269-1276. PMID 28564446 DOI: 10.1111/J.1558-5646.1994.Tb05311.X  0.27
2019 Yamada SB, Gendron TF, Niccoli T, Genuth NR, Grosely R, Shi Y, Glaria I, Kramer NJ, Nakayama L, Fang S, Dinger TJI, Thoeng A, Rocha G, Barna M, Puglisi JD, ... Partridge L, et al. RPS25 is required for efficient RAN translation of C9orf72 and other neurodegenerative disease-associated nucleotide repeats. Nature Neuroscience. PMID 31358992 DOI: 10.1038/S41593-019-0455-7  0.269
2015 Kinghorn KJ, Castillo-Quan JI, Bartolome F, Angelova PR, Li L, Pope S, Cochemé HM, Khan S, Asghari S, Bhatia KP, Hardy J, Abramov AY, Partridge L. Loss of PLA2G6 leads to elevated mitochondrial lipid peroxidation and mitochondrial dysfunction. Brain : a Journal of Neurology. 138: 1801-16. PMID 26001724 DOI: 10.1093/Brain/Awv132  0.269
1981 Partridge L, Maclean R. Effects of nutrition and peripheral stimuli on preferences for familiar foods in the bank vole Animal Behaviour. 29: 217-220. DOI: 10.1016/S0003-3472(81)80169-8  0.268
2003 Calboli FCF, Kennington WJ, Partridge L. QTL mapping reveals a striking coincidence in the positions of genomic regions associated with adaptive variation in body size in parallel clines of Drosophila melanogaster on different continents Evolution. 57: 2653-2658. PMID 14686541 DOI: 10.1111/J.0014-3820.2003.Tb01509.X  0.267
1993 Partridge L, Fowler K. RESPONSES AND CORRELATED RESPONSES TO ARTIFICIAL SELECTION ON THORAX LENGTH IN DROSOPHILA MELANOGASTER. Evolution; International Journal of Organic Evolution. 47: 213-226. PMID 28568094 DOI: 10.1111/J.1558-5646.1993.Tb01211.X  0.266
1997 Fowler K, Semple C, Barton NH, Partridge L. Genetic variation for total fitness in Drosophila melanogaster. Proceedings. Biological Sciences / the Royal Society. 264: 191-9. PMID 9061969 DOI: 10.1098/Rspb.1997.0027  0.266
1995 Partridge L, Barrie B, Barton NH, Fowler K, French V. RAPID LABORATORY EVOLUTION OF ADULT LIFE-HISTORY TRAITS IN DROSOPHILA MELANOGASTER IN RESPONSE TO TEMPERATURE. Evolution; International Journal of Organic Evolution. 49: 538-544. PMID 28565092 DOI: 10.1111/J.1558-5646.1995.Tb02285.X  0.266
2015 Ziehm M, Ivanov DK, Bhat A, Partridge L, Thornton JM. SurvCurv database and online survival analysis platform update. Bioinformatics (Oxford, England). PMID 26249811 DOI: 10.1093/Bioinformatics/Btv463  0.265
1997 Partridge L, Coyne JA. BERGMANN'S RULE IN ECTOTHERMS: IS IT ADAPTIVE? Evolution; International Journal of Organic Evolution. 51: 632-635. PMID 28565342 DOI: 10.1111/j.1558-5646.1997.tb02454.x  0.265
2017 Gorsky MK, Burnouf S, Sofola-Adesakin O, Dols J, Augustin H, Weigelt CM, Grönke S, Partridge L. Pseudo-acetylation of multiple sites on human Tau proteins alters Tau phosphorylation and microtubule binding, and ameliorates amyloid beta toxicity. Scientific Reports. 7: 9984. PMID 28855586 DOI: 10.1038/S41598-017-10225-0  0.265
2000 Partridge L, Barton NH. Evolving evolvability. Nature. 407: 457-8. PMID 11028981 DOI: 10.1038/35035173  0.265
1998 James AC, Partridge L. Geographic variation in competitive ability in Drosophila melanogaster. The American Naturalist. 151: 530-7. PMID 18811374 DOI: 10.1086/286138  0.264
2002 Azevedo RBR, French V, Partridge L. Temperature modulates epidermal cell size in Drosophila melanogaster Journal of Insect Physiology. 48: 231-237. DOI: 10.1016/S0022-1910(01)00168-8  0.263
2012 Aghdam SY, Eming SA, Willenborg S, Neuhaus B, Niessen CM, Partridge L, Krieg T, Bruning JC. Vascular endothelial insulin/IGF-1 signaling controls skin wound vascularization. Biochemical and Biophysical Research Communications. 421: 197-202. PMID 22503682 DOI: 10.1016/j.bbrc.2012.03.134  0.263
2006 Magwere T, Goodall S, Skepper J, Mair W, Brand MD, Partridge L. The effect of dietary restriction on mitochondrial protein density and flight muscle mitochondrial morphology in Drosophila Journals of Gerontology - Series a Biological Sciences and Medical Sciences. 61: 36-47. PMID 16456193 DOI: 10.1093/Gerona/61.1.36  0.262
2016 Gorsky MK, Burnouf S, Dols J, Mandelkow E, Partridge L. Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivo. Scientific Reports. 6: 22685. PMID 26940749 DOI: 10.1038/srep22685  0.262
2023 Baghdadi M, Nespital T, Mesaros A, Buschbaum S, Withers DJ, Grönke S, Partridge L. Reduced insulin signaling in neurons induces sex-specific health benefits. Science Advances. 9: eade8137. PMID 36812323 DOI: 10.1126/sciadv.ade8137  0.262
1996 Azevedo RBR, French V, Partridge L. THERMAL EVOLUTION OF EGG SIZE IN DROSOPHILA MELANOGASTER. Evolution; International Journal of Organic Evolution. 50: 2338-2345. PMID 28565673 DOI: 10.1111/j.1558-5646.1996.tb03621.x  0.26
1979 Partridge L. Differences in behaviour between blue and coal tits reared under identical conditions Animal Behaviour. 27: 120-125. DOI: 10.1016/0003-3472(79)90132-5  0.26
2014 Mizielinska S, Grönke S, Niccoli T, Ridler CE, Clayton EL, Devoy A, Moens T, Norona FE, Woollacott IO, Pietrzyk J, Cleverley K, Nicoll AJ, Pickering-Brown S, Dols J, Cabecinha M, ... ... Partridge L, et al. C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins. Science (New York, N.Y.). 345: 1192-4. PMID 25103406 DOI: 10.1126/Science.1256800  0.26
2003 Kennington WJ, Killeen JR, Goldstein DB, Partridge L. Rapid laboratory evolution of adult wing area in Drosophila melanogaster in response to humidity Evolution. 57: 932-936. PMID 12778562 DOI: 10.1554/0014-3820(2003)057[0932:Rleoaw]2.0.Co;2  0.26
2008 Partridge L. Some highlights of research on aging with invertebrates, 2008. Aging Cell. 7: 605-8. PMID 18631320 DOI: 10.1111/j.1474-9726.2008.00415.x  0.259
1976 Partridge L, Ashcroft R. Mixed-Species Flocks of Birds in Hill Forest in Ceylon The Condor. 78: 449. DOI: 10.2307/1367093  0.258
1986 Partridge L. Genetics of mate choice Trends in Genetics. 2: 1. DOI: 10.1016/0168-9525(86)90150-2  0.258
1977 Partridge L, Pring-Mill F. CANARY ISLAND BLUE TITS AND ENGLISH COAL TITS: CONVERGENT EVOLUTION? Evolution; International Journal of Organic Evolution. 31: 657-665. PMID 28563485 DOI: 10.1111/j.1558-5646.1977.tb01057.x  0.258
2017 Augustin H, McGourty K, Steinert JR, Cochemé HM, Adcott J, Cabecinha M, Vincent A, Halff EF, Kittler JT, Boucrot E, Partridge L. Myostatin-like proteins regulate synaptic function and neuronal morphology. Development (Cambridge, England). PMID 28533206 DOI: 10.1242/Dev.152975  0.258
1989 Partridge L. Frequency-dependent mating preferences in female fruitflies? Behavior Genetics. 19: 725-728. PMID 2508618 DOI: 10.1007/Bf01066034  0.258
1990 Wilkinson GS, Fowler K, Partridge L. RESISTANCE OF GENETIC CORRELATION STRUCTURE TO DIRECTIONAL SELECTION IN DROSOPHILA MELANOGASTER. Evolution; International Journal of Organic Evolution. 44: 1990-2003. PMID 28564436 DOI: 10.1111/J.1558-5646.1990.Tb04305.X  0.257
2001 Barton N, Partridge L. Limits to natural selection. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 22: 1075-84. PMID 11084623 DOI: 10.1002/1521-1878(200012)22:12<1075::Aid-Bies5>3.0.Co;2-M  0.257
2015 Bratic A, Kauppila TE, Macao B, Grönke S, Siibak T, Stewart JB, Baggio F, Dols J, Partridge L, Falkenberg M, Wredenberg A, Larsson NG. Complementation between polymerase- and exonuclease-deficient mitochondrial DNA polymerase mutants in genomically engineered flies. Nature Communications. 6: 8808. PMID 26554610 DOI: 10.1038/Ncomms9808  0.256
2011 Cochemé HM, Quin C, McQuaker SJ, Cabreiro F, Logan A, Prime TA, Abakumova I, Patel JV, Fearnley IM, James AM, Porteous CM, Smith RA, Saeed S, Carré JE, Singer M, ... ... Partridge L, et al. Measurement of H2O2 within living Drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix. Cell Metabolism. 13: 340-50. PMID 21356523 DOI: 10.1016/j.cmet.2011.02.003  0.256
2008 Wong R, Piper MDW, Blanc E, Partridge L. Reply to "Pitfalls of measuring feeding rate in the fruit fly Drosophila melanogaster" [5] Nature Methods. 5: 215. DOI: 10.1038/Nmeth0308-215  0.256
1995 James AC, Partridge L. Thermal evolution of rate of larval development in Drosophila melanogaster in laboratory and field populations Journal of Evolutionary Biology. 8: 315-330. DOI: 10.1046/j.1420-9101.1995.8030315.x  0.255
1976 Partridge L. Field and laboratory observations on the foraging and feeding techniques of blue tits (Parus caeruleus) and coal tits (P. ater) in relation to their habitats Animal Behaviour. 24: 534-544. DOI: 10.1016/S0003-3472(76)80066-8  0.255
2003 Miwa S, St-Pierre J, Partridge L, Brand MD. Superoxide and hydrogen peroxide production by Drosophila mitochondria Free Radical Biology and Medicine. 35: 938-948. PMID 14556858 DOI: 10.1016/S0891-5849(03)00464-7  0.255
2011 Augustin H, Allen MJ, Partridge L. Electrophysiological recordings from the giant fiber pathway of D. melanogaster. Journal of Visualized Experiments : Jove. PMID 21304452 DOI: 10.3791/2412  0.253
1993 Partridge L. Evolutionary biology. Menopause for thought. Nature. 364: 386. PMID 8332205 DOI: 10.1038/364386A0  0.253
2016 Sofola-Adesakin O, Khericha M, Snoeren I, Tsuda L, Partridge L. pGluAβ increases accumulation of Aβ in vivo and exacerbates its toxicity. Acta Neuropathologica Communications. 4: 109. PMID 27717375 DOI: 10.1186/s40478-016-0380-x  0.251
1985 Harvey PH, Partridge L, Nunney L. Evolutionary biology: Group selection and the sex ratio Nature. 313: 10-11. DOI: 10.1038/313010b0  0.251
2001 Gardner M, Fowler K, Partridge L, Barton N. Genetic variation for preadult viability in Drosophila melanogaster Evolution. 55: 1609-1620. PMID 11580020 DOI: 10.1111/J.0014-3820.2001.Tb00680.X  0.251
2017 Mizielinska S, Ridler CE, Balendra R, Thoeng A, Woodling NS, Grässer FA, Plagnol V, Lashley T, Partridge L, Isaacs AM. Bidirectional nucleolar dysfunction in C9orf72 frontotemporal lobar degeneration. Acta Neuropathologica Communications. 5: 29. PMID 28420437 DOI: 10.1186/S40478-017-0432-X  0.25
2021 Baghdadi M, Hinterding HM, Partridge L, Deelen J. From mutation to mechanism: deciphering the molecular function of genetic variants linked to human ageing. Briefings in Functional Genomics. PMID 33690799 DOI: 10.1093/bfgp/elab005  0.25
2016 Kinghorn KJ, Castillo-Quan JI, Li L, Bhatia KP, Abramov AY, Hardy J, Partridge L. Reply: Glial mitochondropathy in infantile neuroaxonal dystrophy: pathophysiological and therapeutic implications. Brain : a Journal of Neurology. PMID 27497489 DOI: 10.1093/Brain/Aww185  0.249
2017 Simone R, Balendra R, Moens TG, Preza E, Wilson KM, Heslegrave A, Woodling NS, Niccoli T, Gilbert-Jaramillo J, Abdelkarim S, Clayton EL, Clarke M, Konrad MT, Nicoll AJ, Mitchell JS, ... ... Partridge L, et al. G-quadruplex-binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo. Embo Molecular Medicine. PMID 29113975 DOI: 10.15252/Emmm.201707850  0.248
2009 Partridge L. Some highlights of research on aging with invertebrates, 2009. Aging Cell. 8: 509-13. PMID 19558590 DOI: 10.1111/j.1474-9726.2009.00498.x  0.248
2015 Burnouf S, Gorsky MK, Dols J, Grönke S, Partridge L. Aβ43 is neurotoxic and primes aggregation of Aβ40 in vivo. Acta Neuropathologica. 130: 35-47. PMID 25862636 DOI: 10.1007/s00401-015-1419-y  0.248
2007 Schuster EF, Blanc E, Partridge L, Thornton JM. Estimation and correction of non-specific binding in a large-scale spike-in experiment. Genome Biology. 8: R126. PMID 17594493 DOI: 10.1186/Gb-2007-8-6-R126  0.248
2005 Gardner MP, Fowler K, Barton NH, Partridge L. Genetic variation for total fitness in Drosophila melanogaster: complex yet replicable patterns. Genetics. 169: 1553-71. PMID 15545656 DOI: 10.1534/Genetics.104.032367  0.247
1987 Jones JS, Coyne JA, Partridge L. Estimation of the Thermal Niche of Drosophila melanogaster Using a Temperature-Sensitive Mutation The American Naturalist. 130: 83-90. DOI: 10.1086/284699  0.247
1997 McCabe J, French V, Partridge L. Joint regulation of cell size and cell number in the wing blade of Drosophila melanogaster. Genetical Research. 69: 61-8. PMID 9164175 DOI: 10.1017/S0016672397002620  0.246
1997 Berrigan D, Partridge L. Influence of temperature and activity on the metabolic rate of adult Drosophila melanogaster Comparative Biochemistry and Physiology Part a: Physiology. 118: 1301-1307. PMID 9505434 DOI: 10.1016/S0300-9629(97)00030-3  0.246
2016 Iyer J, Wang Q, Le T, Pizzo L, Grönke S, Ambegaokar S, Imai Y, Srivastava A, Llamusí Troisí B, Mardon G, Artero R, Jackson GR, Isaacs AM, Partridge L, Kumar JP, et al. Quantitative Assessment of Eye Phenotypes for Functional Genetic Studies Using Drosophila melanogaster. G3 (Bethesda, Md.). PMID 26994292 DOI: 10.1534/G3.116.027060  0.246
2002 Gockel J, Robinson SJW, Kennington WJ, Goldstein DB, Partridge L. Quantitative genetic analysis of natural variation in body size in Drosophila melanogaster Heredity. 89: 145-153. PMID 12136418 DOI: 10.1038/sj.hdy.6800121  0.246
2022 Fraser HC, Kuan V, Johnen R, Zwierzyna M, Hingorani AD, Beyer A, Partridge L. Biological mechanisms of aging predict age-related disease co-occurrence in patients. Aging Cell. e13524. PMID 35259281 DOI: 10.1111/acel.13524  0.246
2017 Piper MDW, Soultoukis GA, Blanc E, Mesaros A, Herbert SL, Juricic P, He X, Atanassov I, Salmonowicz H, Yang M, Simpson SJ, Ribeiro C, Partridge L. Matching Dietary Amino Acid Balance to the In Silico-Translated Exome Optimizes Growth and Reproduction without Cost to Lifespan. Cell Metabolism. 25: 1206. PMID 28467937 DOI: 10.1016/J.Cmet.2017.04.020  0.245
2007 Partridge L. Some highlights of research on aging with invertebrates, 2006-2007 Aging Cell. 6: 595-598. PMID 17725687 DOI: 10.1111/j.1474-9726.2007.00334.x  0.245
2000 Barton NH, Partridge L. Measuring fitness by means of balancer chromosomes. Genetical Research. 75: 297-313. PMID 10893866 DOI: 10.1017/S0016672399004346  0.244
1998 Harvey PH, Partridge L. Different routes to similar ends Nature. 392: 552-553. DOI: 10.1038/33290  0.244
1997 Gilchrist GW, Huey RB, Partridge L. Thermal sensitivity of Drosophila melanogaster: evolutionary responses of adults and eggs to laboratory natural selection at different temperatures. Physiological Zoology. 70: 403-14. PMID 9237300 DOI: 10.1086/515853  0.243
1976 Partridge L. Individual differences in feeding efficiencies and feeding preferences of captive great tits Animal Behaviour. 24: 230-240. DOI: 10.1016/S0003-3472(76)80119-4  0.243
2002 Partridge L, Gems D. A lethal side-effect Nature. 418: 921. PMID 12198525 DOI: 10.1038/418921a  0.243
2014 Mauer J, Chaurasia B, Goldau J, Vogt MC, Ruud J, Nguyen KD, Theurich S, Hausen AC, Schmitz J, Brönneke HS, Estevez E, Allen TL, Mesaros A, Partridge L, Febbraio MA, et al. Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin. Nature Immunology. 15: 423-30. PMID 24681566 DOI: 10.1038/ni.2865  0.242
2013 Baggio F, Bratic A, Mourier A, Kukat C, Habermann B, Partridge L, Larsson N. Role of the mitochondrial protein LRPPRC2 in Drosophila melanogaster Mitochondrion. 13: 909. DOI: 10.1016/J.MITO.2013.07.032  0.242
1981 Partridge L, D'Udine B. Olfactory Preferences of Inbred Mice (Mus Musculus) for Their Own Strain and for Siblings: Effects of Strain, Sex and Cross-Fostering Behaviour. 78: 314-323. DOI: 10.1163/156853981X00374  0.24
2005 Sharma P, Asztalos Z, Ayyub C, de Bruyne M, Dornan AJ, Gomez-Hernandez A, Keane J, Killeen J, Kramer S, Madhavan M, Roe H, Sherkhane PD, Siddiqi K, Silva E, Carlson JR, ... ... Partridge L, et al. Isogenic autosomes to be applied in optimal screening for novel mutants with viable phenotypes in Drosophila melanogaster. Journal of Neurogenetics. 19: 57-85. PMID 16024440 DOI: 10.1080/01677060591007155  0.239
1974 PARTRIDGE L. Habitat selection in titmice Nature. 247: 573-574. DOI: 10.1038/247573A0  0.239
1987 Partridge L. Evolutionary Biology (2nd edn) Trends in Ecology & Evolution. 2: 258. DOI: 10.1016/0169-5347(87)90014-0  0.238
2018 Moens TG, Mizielinska S, Niccoli T, Mitchell JS, Thoeng A, Ridler CE, Grönke S, Esser J, Heslegrave A, Zetterberg H, Partridge L, Isaacs AM. Sense and antisense RNA are not toxic in Drosophila models of C9orf72-associated ALS/FTD. Acta Neuropathologica. PMID 29380049 DOI: 10.1007/S00401-017-1798-3  0.238
2021 Fuentealba M, Fabian DK, Dönertaş HM, Thornton JM, Partridge L. Transcriptomic profiling of long- and short-lived mutant mice implicates mitochondrial metabolism in ageing and shows signatures of normal ageing in progeroid mice. Mechanisms of Ageing and Development. 194: 111437. PMID 33454277 DOI: 10.1016/j.mad.2021.111437  0.236
1993 Santos M, Fowler K, Partridge L. On the use of tester stocks to predict the competitive ability of genotypes. Heredity. 489-95. PMID 1478885 DOI: 10.1038/Hdy.1992.163  0.236
1987 HARVEY P, PARTRIDGE L. When evolution cannot go into reverse Nature. 329: 397-397. DOI: 10.1038/329397A0  0.236
1991 Huey RB, Partridge L, Fowler K. THERMAL SENSITIVITY OF DROSOPHILA MELANOGASTER RESPONDS RAPIDLY TO LABORATORY NATURAL SELECTION. Evolution; International Journal of Organic Evolution. 45: 751-756. PMID 28568829 DOI: 10.1111/J.1558-5646.1991.Tb04343.X  0.235
2013 Chouchani ET, Methner C, Nadtochiy SM, Logan A, Pell VR, Ding S, James AM, Cochemé HM, Reinhold J, Lilley KS, Partridge L, Fearnley IM, Robinson AJ, Hartley RC, Smith RA, et al. Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I. Nature Medicine. 19: 753-9. PMID 23708290 DOI: 10.1038/Nm.3212  0.235
2010 Partridge L. A paradox for biology. Science (New York, N.Y.). 252: 1000-1. PMID 17843250 DOI: 10.1126/SCIENCE.252.5008.1000  0.234
1985 Partridge L, Harvey PH. Evolutionary biology: Costs of reproduction Nature. 316: 20-20. DOI: 10.1038/316020A0  0.232
1987 Partridge L, Green P. An advantage for specialist feeding in jackdaws, Corvus monedula Animal Behaviour. 35: 982-990. DOI: 10.1016/S0003-3472(87)80155-0  0.231
1994 Partridge L, Barrie B, Fowler K, French V. Thermal evolution of pre-adult life history traits in Drosophila melanogaster Journal of Evolutionary Biology. 7: 645-663. DOI: 10.1046/J.1420-9101.1994.7060645.X  0.23
2012 Cochemé HM, Logan A, Prime TA, Abakumova I, Quin C, McQuaker SJ, Patel JV, Fearnley IM, James AM, Porteous CM, Smith RA, Hartley RC, Partridge L, Murphy MP. Using the mitochondria-targeted ratiometric mass spectrometry probe MitoB to measure H2O2 in living Drosophila. Nature Protocols. 7: 946-58. PMID 22517261 DOI: 10.1038/nprot.2012.035  0.228
2015 Logan A, Pell VR, Shaffer KJ, Evans C, Stanley NJ, Robb EL, Prime TA, Chouchani ET, Cochemé HM, Fearnley IM, Vidoni S, James AM, Porteous CM, Partridge L, Krieg T, et al. Assessing the Mitochondrial Membrane Potential in Cells and In Vivo using Targeted Click Chemistry and Mass Spectrometry. Cell Metabolism. PMID 26712463 DOI: 10.1016/j.cmet.2015.11.014  0.227
2007 Schuster EF, Blanc E, Partridge L, Thornton JM. Correcting for sequence biases in present/absent calls. Genome Biology. 8: R125. PMID 17594492 DOI: 10.1186/Gb-2007-8-6-R125  0.227
2023 López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. Hallmarks of aging: An expanding universe. Cell. 186: 243-278. PMID 36599349 DOI: 10.1016/j.cell.2022.11.001  0.226
1992 Partridge L. Evolutionary Genetics and Environmental Stress . By A. A. Hoffmann and P. A. Parsons. Oxford University Press. 1991. Pp. ix + 284. Hardback £35. ISBN 0 19 857732 X. Genetics Research. 59: 63-64. DOI: 10.1017/S0016672300030172  0.224
2010 Fontana L, Partridge L, Longo VD. Dietary restriction: Theory fails to satiate - Response Science. 329: 1015. DOI: 10.1126/science.329.5995.1015  0.224
2021 Kapetanou M, Nespital T, Tain LS, Pahl A, Partridge L, Gonos ES. FoxO1 Is a Novel Regulator of 20S Proteasome Subunits Expression and Activity. Frontiers in Cell and Developmental Biology. 9: 625715. PMID 33634126 DOI: 10.3389/fcell.2021.625715  0.223
1995 Partridge L. Lords of the Fly Trends in Ecology and Evolution. 10: 171. DOI: 10.1016/S0169-5347(00)89034-5  0.223
2021 Fabian DK, Fuentealba M, Dönertaş HM, Partridge L, Thornton JM. Functional conservation in genes and pathways linking ageing and immunity. Immunity & Ageing : I & A. 18: 23. PMID 33990202 DOI: 10.1186/s12979-021-00232-1  0.221
2021 Fabian DK, Melike Dönertaş H, Fuentealba M, Partridge L, Thornton JM. Transposable element landscape in Drosophila populations selected for longevity. Genome Biology and Evolution. PMID 33595657 DOI: 10.1093/gbe/evab031  0.22
2011 Murphy MP, Holmgren A, Larsson NG, Halliwell B, Chang CJ, Kalyanaraman B, Rhee SG, Thornalley PJ, Partridge L, Gems D, Nyström T, Belousov V, Schumacker PT, Winterbourn CC. Unraveling the biological roles of reactive oxygen species. Cell Metabolism. 13: 361-6. PMID 21459321 DOI: 10.1016/J.Cmet.2011.03.010  0.219
2012 Partridge L. Current developments at Philosophical Transactions of the Royal Society B. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 367: 3. PMID 22106421 DOI: 10.1098/rstb.2011.0315  0.219
1991 Loxdale HD, Harvey PH, Partridge L. Oxford Surveys in Evolutionary Biology Journal of Animal Ecology. 60: 371. DOI: 10.2307/5468  0.219
2018 Woodling NS, Partridge L. Parkinson's Disease: Mitochondria Parked at the ER Hit the Snooze Button. Neuron. 98: 1059-1061. PMID 29953866 DOI: 10.1016/j.neuron.2018.06.025  0.217
1991 Partridge L. Growing old gracefully Nature. 351: 198-198. DOI: 10.1038/351198A0  0.215
1983 Partridge L. Colour of success Nature. 305: 78-78. DOI: 10.1038/305078A0  0.215
1993 Partridge L, Harvey PH. Methuselah among nematodes Nature. 366: 404-405. PMID 8247143 DOI: 10.1038/366404a0  0.215
2016 Partridge L. Gerontology: Extending the healthspan Nature. 529: 154-154. DOI: 10.1038/529154A  0.214
2024 Wang HL, Siow R, Schmauck-Medina T, Zhang J, Sandset PM, Filshie C, Lund Ø, Partridge L, Bergersen LH, Juel Rasmussen L, Palikaras K, Sotiropoulos I, Storm-Mathisen J, Rubinsztein DC, Spillantini MG, et al. Meeting summary of The NYO3 5th NO-Age/AD meeting and the 1st Norway-UK joint meeting on ageing and dementia: recent progress on the mechanisms and interventional strategies. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. PMID 38289789 DOI: 10.1093/gerona/glae029  0.213
2015 Adesakin OA, Kerr F, Partridge L. P1-034: A role for lithium in rescuing amyloid beta pathology in an inducible drosophila model of Alzheimer's disease Alzheimer's & Dementia. 11: P349-P350. DOI: 10.1016/j.jalz.2015.06.230  0.211
2017 Niccoli T, Moens T, Thoeng A, Konrad M, Partridge L, Isaacs AM. Screening For Modifiers Of C9Orf72 Hexanucleotide Repeat Expansion Toxicity In Drosophila Alzheimers & Dementia. 13: 992. DOI: 10.1016/J.Jalz.2017.06.1361  0.211
1986 Partridge L. Unravelling animal behaviour Trends in Ecology and Evolution. 1: 81-82. DOI: 10.1016/0169-5347(86)90025-X  0.211
2004 Eyre TA, Partridge L, Thornton JM. Computational analysis of alpha-helical membrane protein structure: implications for the prediction of 3D structural models. Protein Engineering, Design & Selection : Peds. 17: 613-24. PMID 15388845 DOI: 10.1093/Protein/Gzh072  0.211
1988 PARTRIDGE L, MORGAN MJ. Is bacterial evolution random or selective? Nature. 336: 22-22. DOI: 10.1038/336022A0  0.211
1986 Partridge L, Harvey P. Evolution: Contentious issues in sexual selection Nature. 323: 580-581. DOI: 10.1038/323580A0  0.211
2014 Modi N, Vohra J, Preston J, Elliott C, Van't Hoff W, Coad J, Gibson F, Partridge L, Brierley J, Larcher V, Greenough A. Guidance on clinical research involving infants, children and young people: an update for researchers and research ethics committees. Archives of Disease in Childhood. 99: 887-91. PMID 24914095 DOI: 10.1136/archdischild-2014-306444  0.21
2015 Menger KE, James AM, Cochemé HM, Harbour ME, Chouchani ET, Ding S, Fearnley IM, Partridge L, Murphy MP. Fasting, but Not Aging, Dramatically Alters the Redox Status of Cysteine Residues on Proteins in Drosophila melanogaster. Cell Reports. 13: 1285. PMID 28873344 DOI: 10.1016/j.celrep.2015.10.048  0.21
2015 Ashcroft F, Pearce E, Partridge L, Suomalainen A, Brunet A, Schulze A, Tseng YH, Sethi JK, Reue K, Kingwell B, McNally E, Cnop M, Hevener AL, Diano S. Women in Metabolism: Part 3. Cell Metabolism. 22: 949-53. PMID 26636490 DOI: 10.1016/J.Cmet.2015.11.005  0.208
2023 Monzó C, Gkioni L, Beyer A, Valenzano DR, Grönke S, Partridge L. Dietary restriction mitigates the age-associated decline in mouse B cell receptor repertoire diversity. Cell Reports. 42: 112722. PMID 37384530 DOI: 10.1016/j.celrep.2023.112722  0.208
2012 Partridge L. Measuring reproductive costs. Trends in Ecology & Evolution. 7: 99-100. PMID 21235966 DOI: 10.1016/0169-5347(92)90250-F  0.207
2010 Kerr FK, Gandy C, Lovestone S, Partridge L. P1-109: Oxidative damage and the neuropathology of Alzheimer's disease in Drosophila Alzheimer's & Dementia. 6: S206-S206. DOI: 10.1016/J.Jalz.2010.05.658  0.207
2014 Tuthill D, Sammons H, Tomlin S, Partridge L, Olson K, Fox A. G395 More and More Parents are taking their Medicines for Children Archives of Disease in Childhood. 99. DOI: 10.1136/Archdischild-2014-306237.376  0.207
2021 Atilano ML, Grönke S, Niccoli T, Kempthorne L, Hahn O, Morón-Oset J, Hendrich O, Dyson M, Adams ML, Hull A, Salcher-Konrad MT, Monaghan A, Bictash M, Glaria I, Isaacs AM, ... Partridge L, et al. Enhanced insulin signalling ameliorates C9orf72 hexanucleotide repeat expansion toxicity in . Elife. 10. PMID 33739284 DOI: 10.7554/eLife.58565  0.206
1994 Partridge L, Bruford M. Population biology. A crash course in survival. Nature. 372: 318-9. PMID 7969484 DOI: 10.1038/372318A0  0.206
2008 Milton CC, Partridge L. Brief carbon dioxide exposure blocks heat hardening but not cold acclimation in Drosophila melanogaster. Journal of Insect Physiology. 54: 32-40. PMID 17884085 DOI: 10.1016/j.jinsphys.2007.08.001  0.204
2016 Partridge L. Comments from the departing Editor. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 371. PMID 26729943 DOI: 10.1098/rstb.2015.0471  0.203
2023 Baghdadi M, Mesaros A, Purrio M, Partridge L. Sex-specific effects of Cre expression in Syn1Cre mice. Scientific Reports. 13: 10037. PMID 37340054 DOI: 10.1038/s41598-023-37029-9  0.202
2023 Hahn O, Foltz AG, Atkins M, Kedir B, Moran-Losada P, Guldner IH, Munson C, Kern F, Pálovics R, Lu N, Zhang H, Kaur A, Hull J, Huguenard JR, Grönke S, ... ... Partridge L, et al. Atlas of the aging mouse brain reveals white matter as vulnerable foci. Cell. PMID 37591239 DOI: 10.1016/j.cell.2023.07.027  0.202
2019 Zolotas E, Sammons H, Tuthill D, Barker C, Tomlin S, Partridge L, Rossiter A, Osmond V, Barham H, Fox A. P118 ‘Medicines for Children’ project: putting families and carers in the centre Archives of Disease in Childhood. 104. DOI: 10.1136/Archdischild-2019-Esdppp.156  0.202
1983 Jones JS, Partridge L. Tissue rejection: the price of sexual acceptance? Nature. 304: 484-5. PMID 6683787 DOI: 10.1038/304484A0  0.202
2021 Bolukbasi E, Woodling NS, Ivanov DK, Adcott J, Foley A, Rajasingam A, Gittings LM, Aleyakpo B, Niccoli T, Thornton JM, Partridge L. Cell type-specific modulation of healthspan by Forkhead family transcription factors in the nervous system. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33593901 DOI: 10.1073/pnas.2011491118  0.2
2015 Partridge L. Celebrating 350 years of Philosophical Transactions: life sciences papers. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 370. PMID 25750243 DOI: 10.1098/rstb.2014.0380  0.2
1990 Brown G, Partridge L, Field H. Cell-mediated immunity in calves experimentally infected with BHV-1. Veterinary Record. 127: 454-455. DOI: 10.1136/Vr.127.18.454  0.198
1987 Partridge L, Harvey PH. A case of mistaken identity in swordtail fish Nature. 328: 378-378. DOI: 10.1038/328377A0  0.197
1992 Partridge L, Harvey PH. What the sperm count costs Nature. 360: 415. DOI: 10.1038/360415a0  0.196
2021 Dönertaş HM, Fabian DK, Valenzuela MF, Partridge L, Thornton JM. Common genetic associations between age-related diseases. Nature Aging. 1: 400-412. PMID 33959723 DOI: 10.1038/s43587-021-00051-5  0.196
2005 Kerrison ND, Selman C, Lingard SJ, Thornton JM, Partridge L, Withers DJ. Living longer by dieting: analysis of transcriptional response after caloric restriction Bmc Bioinformatics. 6: S6. DOI: 10.1186/1471-2105-6-S3-S6  0.192
1988 Harvey PH, Partridge L. Of cuckoo clocks and cowbirds Nature. 335: 586-587. DOI: 10.1038/335586A0  0.187
2021 Pouikli A, Parekh S, Maleszewska M, Nikopoulou C, Baghdadi M, Tripodi I, Folz-Donahue K, Hinze Y, Mesaros A, Hoey D, Giavalisco P, Dowell R, Partridge L, Tessarz P. Chromatin remodeling due to degradation of citrate carrier impairs osteogenesis of aged mesenchymal stem cells. Nature Aging. 1: 810-825. PMID 37117628 DOI: 10.1038/s43587-021-00105-8  0.184
1987 Harvey PH, Partridge L. Murderous mandibles and black holes in hymenopteran wasps Nature. 326: 128-129. DOI: 10.1038/326128A0  0.182
1989 Partridge L. Book review Animal Behaviour. 38: 363. DOI: 10.1016/S0003-3472(89)80101-0  0.182
1989 Partridge L. Book review Animal Behaviour. 37: 170-171. DOI: 10.1016/0003-3472(89)90026-2  0.182
1986 Partridge L. Book review Animal Behaviour. 34: 632-633. DOI: 10.1016/S0003-3472(86)80150-6  0.182
1986 Partridge L, Brown CH. Book review Animal Behaviour. 34: 947-949. DOI: 10.1016/S0003-3472(86)80093-8  0.182
1983 Partridge L. Book review Animal Behaviour. 31: 961. DOI: 10.1016/S0003-3472(83)80267-X  0.182
1976 Partridge L. Book review Animal Behaviour. 24: 719. DOI: 10.1016/S0003-3472(76)80085-1  0.182
1982 Harvey PH, Partridge L. Bird coloration and parasites — a task for the future? Nature. 300: 480-481. DOI: 10.1038/300480A0  0.18
2011 Partridge L. Comments from the new editor Philosophical Transactions of the Royal Society B: Biological Sciences. 366: 5. DOI: 10.1098/rstb.2010.0314  0.178
1977 partridge L, Nunney L. Three-generation family conflict Animal Behaviour. 25: 785-786. DOI: 10.1016/0003-3472(77)90131-2  0.177
2005 Partridge L. Haldane's rule and the hazards of heterogamety. Current Biology : Cb. 3: 56-8. PMID 15335885 DOI: 10.1016/0960-9822(93)90152-E  0.175
2013 Tomlin S, Fox A, Sammons H, Partridge L, Vohra J, Olson K. Medicines for Children: reliable information for parents and carers Prescriber. 24: 5-6. DOI: 10.1002/Psb.1000  0.171
2021 Kaeser SA, Lehallier B, Thinggaard M, Häsler LM, Apel A, Bergmann C, Berdnik D, Jeune B, Christensen K, Grönke S, Partridge L, Wyss-Coray T, Mengel-From J, Jucker M. A neuronal blood marker is associated with mortality in old age. Nature Aging. 1: 218-225. PMID 37118632 DOI: 10.1038/s43587-021-00028-4  0.17
2021 Nespital T, Neuhaus B, Mesaros A, Pahl A, Partridge L. Lithium can mildly increase health during ageing but not lifespan in mice. Aging Cell. e13479. PMID 34532960 DOI: 10.1111/acel.13479  0.165
2023 Sahota VK, Stone A, Woodling NS, Spiers JG, Steinert JR, Partridge L, Augustin H. Plum modulates Myoglianin and regulates synaptic function in . Open Biology. 13: 230171. PMID 37699519 DOI: 10.1098/rsob.230171  0.161
2005 Mair W, Piper MDW, Partridge L. Calories do not explain extension of life span by dietary restriction in Drosophila Plos Biology. 3: 1305-1311. DOI: 10.1371/journal.pbio.0030223  0.16
2019 Augustin H, Zylbertal A, Partridge L. A Computational Model of the Escape Response Latency in the Giant Fiber System of . Eneuro. 6. PMID 31001574 DOI: 10.1523/ENEURO.0423-18.2019  0.155
2020 Ivanov DK, Bostelmann G, Lan-Leung B, Williams J, Partridge L, Escott-Price V, Thornton JM. A novel computational approach for predicting complex phenotypes in Drosophila (starvation-sensitive and sterile) by deriving their gene expression signatures from public data. Plos One. 15: e0240824. PMID 33104720 DOI: 10.1371/journal.pone.0240824  0.155
2021 Kuan V, Fraser HC, Hingorani M, Denaxas S, Gonzalez-Izquierdo A, Direk K, Nitsch D, Mathur R, Parisinos CA, Lumbers RT, Sofat R, Wong ICK, Casas JP, Thornton JM, Hemingway H, ... Partridge L, et al. Data-driven identification of ageing-related diseases from electronic health records. Scientific Reports. 11: 2938. PMID 33536532 DOI: 10.1038/s41598-021-82459-y  0.154
2015 Partridge L, Thornton J, Bates G. The new science of ageing. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 370. PMID 26194762 DOI: 10.1098/rstb.2015.0249  0.151
2020 Lu J, Temp U, Müller-Hartmann A, Esser J, Grönke S, Partridge L. Sestrin is a key regulator of stem cell function and lifespan in response to dietary amino acids. Nature Aging. 1: 60-72. PMID 37117991 DOI: 10.1038/s43587-020-00001-7  0.15
2021 Niccoli T, Kerr F, Snoeren I, Fabian D, Aleyakpo B, Ivanov D, Sofola-Adesakin O, Cryar A, Adcott J, Thornton J, Partridge L. Activating transcription factor 4-dependent lactate dehydrogenase activation as a protective response to amyloid beta toxicity. Brain Communications. 3: fcab053. PMID 33977265 DOI: 10.1093/braincomms/fcab053  0.149
2023 Atilano ML, Hull A, Romila CA, Adams ML, Wildfire J, Ureña E, Dyson M, Ivan-Castillo-Quan J, Partridge L, Kinghorn KJ. Autophagic dysfunction and gut microbiota dysbiosis cause chronic immune activation in a Drosophila model of Gaucher disease. Plos Genetics. 19: e1011063. PMID 38127816 DOI: 10.1371/journal.pgen.1011063  0.147
2022 Srivastava A, Lu J, Gadalla DS, Hendrich O, Grönke S, Partridge L. The Role of GCN2 Kinase in Mediating the Effects of Amino Acids on Longevity and Feeding Behaviour in . Frontiers in Aging. 3: 944466. PMID 35821827 DOI: 10.3389/fragi.2022.944466  0.146
2017 Kennedy BK, Partridge L. 2nd interventions in aging conference. Aging. PMID 28455971 DOI: 10.18632/aging.101221  0.144
2000 Zwaan BJ, Azevedo RBR, James AC, Van 'T Land J, Partridge L. Cellular of wing size variation in Drosophila melanogaster: A comparison of latitudinal clines on two continents Heredity. 84: 338-347. DOI: 10.1046/j.1365-2540.2000.00677.x  0.136
2020 Scholes HM, Cryar A, Kerr F, Sutherland D, Gethings LA, Vissers JPC, Lees JG, Orengo CA, Partridge L, Thalassinos K. Dynamic changes in the brain protein interaction network correlates with progression of Aβ42 pathology in Drosophila. Scientific Reports. 10: 18517. PMID 33116184 DOI: 10.1038/s41598-020-74748-9  0.135
2019 Solon-Biet SM, Cogger VC, Pulpitel T, Wahl D, Clark X, Bagley E, Gregoriou GC, Senior AM, Wang QP, Brandon AE, Perks R, O'Sullivan J, Koay YC, Bell-Anderson K, Kebede M, ... ... Partridge L, et al. Branched chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control. Nature Metabolism. 1: 532-545. PMID 31656947 DOI: 10.1038/s42255-019-0059-2  0.134
2021 Li L, Conradson DM, Bharat V, Kim MJ, Hsieh CH, Minhas PS, Papakyrikos AM, Durairaj AS, Ludlam A, Andreasson KI, Partridge L, Cianfrocco MA, Wang X. A mitochondrial membrane-bridging machinery mediates signal transduction of intramitochondrial oxidation. Nature Metabolism. PMID 34504353 DOI: 10.1038/s42255-021-00443-2  0.126
2011 Cruz-Migoni A, Hautbergue GM, Artymiuk PJ, Baker PJ, Bokori-Brown M, Chang CT, Dickman MJ, Essex-Lopresti A, Harding SV, Mahadi NM, Marshall LE, Mobbs GW, Mohamed R, Nathan S, Ngugi SA, ... ... Partridge LJ, et al. A Burkholderia pseudomallei toxin inhibits helicase activity of translation factor eIF4A. Science (New York, N.Y.). 334: 821-4. PMID 22076380 DOI: 10.1126/Science.1211915  0.126
2008 Tanner DC, Qiu S, Bolognani F, Partridge LD, Weeber EJ, Perrone-Bizzozero NI. Alterations in mossy fiber physiology and GAP-43 expression and function in transgenic mice overexpressing HuD. Hippocampus. 18: 814-23. PMID 18493953 DOI: 10.1002/Hipo.20442  0.122
2024 Zhang P, Catterson JH, Grönke S, Partridge L. Inhibition of S6K lowers age-related inflammation and increases lifespan through the endolysosomal system. Nature Aging. PMID 38413780 DOI: 10.1038/s43587-024-00578-3  0.12
2024 Baghdadi M, Nespital T, Monzó C, Deelen J, Grönke S, Partridge L. Intermittent rapamycin feeding recapitulates some effects of continuous treatment while maintaining lifespan extension. Molecular Metabolism. 81: 101902. PMID 38360109 DOI: 10.1016/j.molmet.2024.101902  0.12
2009 Hassuna N, Monk PN, Moseley GW, Partridge LJ. Strategies for targeting tetraspanin proteins: potential therapeutic applications in microbial infections. Biodrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy. 23: 341-59. PMID 19894777 DOI: 10.2165/11315650-000000000-00000  0.119
2023 Catterson JH, Minkley L, Aspe S, Judd-Mole S, Moura S, Dyson MC, Rajasingam A, Woodling NS, Atilano ML, Ahmad M, Durrant CS, Spires-Jones TL, Partridge L. Protein retention in the endoplasmic reticulum rescues Aβ toxicity in Drosophila. Neurobiology of Aging. 132: 154-174. PMID 37837732 DOI: 10.1016/j.neurobiolaging.2023.09.008  0.111
2003 Kennington WJ, Gockel J, Partridge L. Testing for Asymmetrical Gene Flow in a Drosophila melanogaster Body-Size Cline Genetics. 165: 667-673. PMID 14573478  0.108
1991 Partridge L, Bell G. Sex and Death in Protozoa The Journal of Animal Ecology. 60: 369. DOI: 10.2307/5466  0.108
2024 Milioto C, Carcolé M, Giblin A, Coneys R, Attrebi O, Ahmed M, Harris SS, Lee BI, Yang M, Ellingford RA, Nirujogi RS, Biggs D, Salomonsson S, Zanovello M, de Oliveira P, ... ... Partridge L, et al. PolyGR and polyPR knock-in mice reveal a conserved neuroprotective extracellular matrix signature in C9orf72 ALS/FTD neurons. Nature Neuroscience. PMID 38424324 DOI: 10.1038/s41593-024-01589-4  0.104
2011 Triki? MZ, Monk P, Roehl H, Partridge LJ. Regulation of zebrafish hatching by tetraspanin cd63. Plos One. 6: e19683. PMID 21625559 DOI: 10.1371/journal.pone.0019683  0.104
2022 Kuan V, Denaxas S, Patalay P, Nitsch D, Mathur R, Gonzalez-Izquierdo A, Sofat R, Partridge L, Roberts A, Wong ICK, Hingorani M, Chaturvedi N, Hemingway H, Hingorani AD. Identifying and visualising multimorbidity and comorbidity patterns in patients in the English National Health Service: a population-based study. The Lancet. Digital Health. PMID 36460578 DOI: 10.1016/S2589-7500(22)00187-X  0.103
2023 Morón-Oset J, Fischer LKS, Jauré N, Zhang P, Jahn AJ, Supèr T, Pahl A, Isaacs AM, Grönke S, Partridge L. Repeat length of C9orf72-associated glycine-alanine polypeptides affects their toxicity. Acta Neuropathologica Communications. 11: 140. PMID 37644512 DOI: 10.1186/s40478-023-01634-6  0.101
2000 Gilchrist AS, Partridge L. WHY IT IS DIFFICULT TO MODEL SPERM DISPLACEMENT IN DROSOPHILA MELANOGASTER: THE RELATION BETWEEN SPERM TRANSFER AND COPULATION DURATION Evolution. 54: 534. DOI: 10.1554/0014-3820(2000)054[0534:WIIDTM]2.0.CO;2  0.101
2000 Robinson SJW, Zwaan B, Partridge L. STARVATION RESISTANCE AND ADULT BODY COMPOSITION IN A LATITUDINAL CLINE OF DROSOPHILA MELANOGASTER Evolution. 54: 1819. DOI: 10.1554/0014-3820(2000)054[1819:SRAABC]2.0.CO;2  0.094
2013 Baca M, Allan AM, Partridge LD, Wilson MC. Gene-environment interactions affect long-term depression (LTD) through changes in dopamine receptor affinity in Snap25 deficient mice. Brain Research. 1532: 85-98. PMID 23939223 DOI: 10.1016/J.Brainres.2013.08.012  0.093
2008 Valenzuela CF, Partridge LD, Mameli M, Meyer DA. Modulation of glutamatergic transmission by sulfated steroids: role in fetal alcohol spectrum disorder. Brain Research Reviews. 57: 506-19. PMID 17597219 DOI: 10.1016/J.Brainresrev.2007.04.009  0.091
2012 Monk PN, Partridge LJ. Tetraspanins: gateways for infection. Infectious Disorders Drug Targets. 12: 4-17. PMID 22034932  0.091
2011 Green LR, Monk PN, Partridge LJ, Morris P, Gorringe AR, Read RC. Cooperative role for tetraspanins in adhesin-mediated attachment of bacterial species to human epithelial cells. Infection and Immunity. 79: 2241-9. PMID 21464080 DOI: 10.1128/IAI.01354-10  0.09
2021 Annibal A, Tharyan RG, Schonewolff MF, Tam H, Latza C, Auler MMK, Grönke S, Partridge L, Antebi A. Author Correction: Regulation of the one carbon folate cycle as a shared metabolic signature of longevity. Nature Communications. 12: 5025. PMID 34385439 DOI: 10.1038/s41467-021-24840-z  0.085
2011 Fanaei M, Monk PN, Partridge LJ. The role of tetraspanins in fusion. Biochemical Society Transactions. 39: 524-8. PMID 21428932 DOI: 10.1042/BST0390524  0.084
2023 Morón-Oset J, Fischer LK, Carcolé M, Giblin A, Zhang P, Isaacs AM, Grönke S, Partridge L. Toxicity of -associated dipeptide repeat peptides is modified by commonly used protein tags. Life Science Alliance. 6. PMID 37308278 DOI: 10.26508/lsa.202201739  0.081
2012 Sofola O, Kerr F, Rogers I, Killick R, Augustin H, Gandy C, Allen MJ, Hardy J, Lovestone S, Partridge L. Correction: Inhibition of GSK-3 Ameliorates Aβ Pathology in an Adult-Onset Drosophila Model of Alzheimer's Disease Plos Genetics. 8. DOI: 10.1371/annotation/baa8a2a9-130b-4959-b6fb-6f786fd02826  0.079
2016 Niccoli T, Cabecinha M, Tillmann A, Kerr F, Wong CT, Cardenes D, Vincent AJ, Bettedi L, Li L, Grönke S, Dols J, Partridge L. Increased Glucose Transport into Neurons Rescues Aβ Toxicity in Drosophila. Current Biology : Cb. 26: 2550. PMID 27676294 DOI: 10.1016/j.cub.2016.09.018  0.077
2003 Partridge L. Forever young Nature. 421: 789-790. DOI: 10.1038/421789a  0.077
1989 Divecha N, Mansouri H, Peat D, Cope G, Partridge L, McDonald CJ. Isoprenaline-induced and constitutive members of a proline-rich protein sub-group from mouse parotid glands studied with monoclonal antibody NAL1. Journal of Molecular Endocrinology. 3: 7-14. PMID 2742745 DOI: 10.1677/jme.0.0030007  0.075
2012 Scullin CS, Tafoya LC, Wilson MC, Partridge LD. Presynaptic residual calcium and synaptic facilitation at hippocampal synapses of mice with altered expression of SNAP-25. Brain Research. 1431: 1-12. PMID 22119397 DOI: 10.1016/J.Brainres.2011.10.035  0.075
2007 Wright AJ, Higginbottom A, Philippe D, Upadhyay A, Bagby S, Read RC, Monk PN, Partridge LJ. Characterisation of receptor binding by the chemotaxis inhibitory protein of Staphylococcus aureus and the effects of the host immune response. Molecular Immunology. 44: 2507-17. PMID 17258808 DOI: 10.1016/j.molimm.2006.12.022  0.071
2006 Pizzari T, Birkhead TR, Blows MW, Brooks R, Buchanan KL, Clutton-Brock TH, Harvey PH, Hosken DJ, Jennions MD, Kokko H, Kotiaho JS, Lessells CM, Macias-García C, Moore AJ, Parker GA, ... Partridge L, et al. Debating sexual selection and mating strategies [3] Science. 312: 690.  0.07
2010 Schiess AR, Scullin C, Partridge LD. Maturation of Schaffer collateral synapses generates a phenotype of unreliable basal evoked release and very reliable facilitated release. The European Journal of Neuroscience. 31: 1377-87. PMID 20384768 DOI: 10.1111/J.1460-9568.2010.07180.X  0.068
2015 Rust A, Hassan HH, Sedelnikova S, Niranjan D, Hautbergue G, Abbas SA, Partridge L, Rice D, Binz T, Davletov B. Two complementary approaches for intracellular delivery of exogenous enzymes. Scientific Reports. 5: 12444. PMID 26207613 DOI: 10.1038/Srep12444  0.068
2019 Weigelt CM, Hahn O, Arlt K, Gruhn M, Jahn AJ, Eßer J, Werner JA, Klein C, Büschges A, Grönke S, Partridge L. Loss of miR-210 leads to progressive retinal degeneration in . Life Science Alliance. 2. PMID 30670478 DOI: 10.26508/lsa.201800149  0.067
2015 Casarrubea M, Davies C, Faulisi F, Pierucci M, Colangeli R, Partridge L, Chambers S, Cassar D, Valentino M, Muscat R, Benigno A, Crescimanno G, Di Giovanni G. Acute nicotine induces anxiety and disrupts temporal pattern organization of rat exploratory behavior in hole-board: a potential role for the lateral habenula. Frontiers in Cellular Neuroscience. 9: 197. PMID 26082682 DOI: 10.3389/fncel.2015.00197  0.067
2008 Butler RN, Miller RA, Perry D, Carnes BA, Williams TF, Cassel C, Brody J, Bernard MA, Partridge L, Kirkwood T, Martin GM, Olshansky SJ. New model of health promotion and disease prevention for the 21st century. Bmj (Clinical Research Ed.). 337: a399. PMID 18614506 DOI: 10.1136/bmj.a399  0.06
2012 Jelinek DA, Partridge LD. GABA(A) receptor mediated inhibition contributes to corticostriatal frequency filtering. Neuroscience Letters. 530: 133-7. PMID 23069672 DOI: 10.1016/J.Neulet.2012.09.061  0.059
2015 Norman A, Persson M, Stock N, Rumsey N, Sandy J, Waylen A, Edwards Z, Hammond V, Partridge L, Ness A. The Effectiveness of Psychosocial Intervention for Individuals With Cleft Lip and/or Palate. The Cleft Palate-Craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association. 52: 301-10. PMID 24878344 DOI: 10.1597/13-276  0.058
2021 Dzankic PJ, Partridge L. Clinical trials of mTOR inhibitors to boost immunity to viral infection in older adults. The Lancet. Healthy Longevity. 2: e232-e233. PMID 33977282 DOI: 10.1016/S2666-7568(21)00090-8  0.058
2010 Scullin CS, Wilson MC, Partridge LD. Developmental changes in presynaptic Ca(2 +) clearance kinetics and synaptic plasticity in mouse Schaffer collateral terminals. The European Journal of Neuroscience. 31: 817-26. PMID 20374283 DOI: 10.1111/J.1460-9568.2010.07137.X  0.056
2003 Barnes AI, Partridge L. Costing reproduction Animal Behaviour. 66: 199-204. DOI: 10.1006/anbe.2003.2122  0.054
2014 Hulme RS, Higginbottom A, Palmer J, Partridge LJ, Monk PN. Distinct regions of the large extracellular domain of tetraspanin CD9 are involved in the control of human multinucleated giant cell formation. Plos One. 9: e116289. PMID 25551757 DOI: 10.1371/journal.pone.0116289  0.053
2006 Schiess AR, Scullin CS, Partridge LD. Neurosteroid-induced enhancement of short-term facilitation involves a component downstream from presynaptic calcium in hippocampal slices. The Journal of Physiology. 576: 833-47. PMID 16931546 DOI: 10.1113/Jphysiol.2006.118505  0.052
2008 Partridge LE, Loughnane E. Greening your skyscraper case study in improving the environmental performance of an existing skyscraper Ctbuh 2008, 8th World Congress - Tall and Green: Typology For a Sustainable Urban Future, Congress Proceedings. 218-225.  0.051
2012 Scullin CS, Partridge LD. Modulation by pregnenolone sulfate of filtering properties in the hippocampal trisynaptic circuit. Hippocampus. 22: 2184-98. PMID 22648992 DOI: 10.1002/Hipo.22038  0.051
2011 Wells N, Partridge L. Families are key in improving quality. Academic Pediatrics. 11: S85-6. PMID 21570021 DOI: 10.1016/j.acap.2011.01.005  0.044
2020 Cox LS, Bellantuono I, Lord JM, Sapey E, Mannick JB, Partridge L, Gordon AL, Steves CJ, Witham MD. Tackling immunosenescence to improve COVID-19 outcomes and vaccine response in older adults. The Lancet. Healthy Longevity. 1: e55-e57. PMID 33521768 DOI: 10.1016/S2666-7568(20)30011-8  0.042
2006 Ho SH, Martin F, Higginbottom A, Partridge LJ, Parthasarathy V, Moseley GW, Lopez P, Cheng-Mayer C, Monk PN. Recombinant extracellular domains of tetraspanin proteins are potent inhibitors of the infection of macrophages by human immunodeficiency virus type 1. Journal of Virology. 80: 6487-96. PMID 16775336 DOI: 10.1128/JVI.02539-05  0.041
2013 Sun B, Miller G, Lee WY, Ho K, Crowe MA, Partridge L. Analytical method development for directed enzyme evolution research: a high throughput high-performance liquid chromatography method for analysis of ribose and ribitol and a capillary electrophoresis method for the separation of ribose enantiomers. Journal of Chromatography. A. 1271: 163-9. PMID 23237716 DOI: 10.1016/j.chroma.2012.11.042  0.041
2009 Parthasarathy V, Martin F, Higginbottom A, Murray H, Moseley GW, Read RC, Mal G, Hulme R, Monk PN, Partridge LJ. Distinct roles for tetraspanins CD9, CD63 and CD81 in the formation of multinucleated giant cells. Immunology. 127: 237-48. PMID 19489128 DOI: 10.1111/j.1365-2567.2008.02945.x  0.04
2006 Partridge L, Russell WJ. The margin of safety of a left double-lumen tracheobronchial tube depends on the length of the bronchial cuff and tip Anaesthesia and Intensive Care. 34: 618-620. PMID 17061637  0.04
2014 Partridge L. Achieving a Six-Star Rated Tall Building in Sydney's Central Business District Ctbuh Journal. 34-39.  0.037
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