| Year |
Citation |
Score |
| 2018 |
Sowers CR, Wang R, Bourne RA, McGrath BC, Hu J, Bevilacqua SC, Paton JC, Paton AW, Collardeau-Frachon S, Nicolino M, Cavener DR. The protein kinase PERK/EIF2AK3 regulates proinsulin processing not via protein synthesis but by controlling endoplasmic reticulum chaperones. The Journal of Biological Chemistry. PMID 29444822 DOI: 10.1074/Jbc.M117.813790 |
0.313 |
|
| 2014 |
Wang R, Munoz EE, Zhu S, McGrath BC, Cavener DR. Perk gene dosage regulates glucose homeostasis by modulating pancreatic β-cell functions. Plos One. 9: e99684. PMID 24915520 DOI: 10.1371/Journal.Pone.0099684 |
0.323 |
|
| 2013 |
Xu X, Hu J, McGrath BC, Cavener DR. GCN2 in the brain programs PPARγ2 and triglyceride storage in the liver during perinatal development in response to maternal dietary fat. Plos One. 8: e75917. PMID 24130751 DOI: 10.1371/Journal.Pone.0075917 |
0.38 |
|
| 2013 |
Xu X, Hu J, McGrath BC, Cavener DR. GCN2 regulates the CCAAT enhancer binding protein beta and hepatic gluconeogenesis. American Journal of Physiology. Endocrinology and Metabolism. 305: E1007-17. PMID 23900421 DOI: 10.1152/Ajpendo.00063.2013 |
0.401 |
|
| 2011 |
Xu X, Gupta S, Hu W, McGrath BC, Cavener DR. Hyperthermia induces the ER stress pathway. Plos One. 6: e23740. PMID 21876766 DOI: 10.1371/Journal.Pone.0023740 |
0.522 |
|
| 2010 |
Cavener DR, Gupta S, McGrath BC. PERK in beta cell biology and insulin biogenesis. Trends in Endocrinology and Metabolism: Tem. 21: 714-21. PMID 20850340 DOI: 10.1016/J.Tem.2010.08.005 |
0.425 |
|
| 2010 |
Gupta S, McGrath B, Cavener DR. PERK (EIF2AK3) regulates proinsulin trafficking and quality control in the secretory pathway. Diabetes. 59: 1937-47. PMID 20530744 DOI: 10.2337/Db09-1064 |
0.454 |
|
| 2009 |
Gupta S, McGrath B, Cavener DR. PERK regulates the proliferation and development of insulin-secreting beta-cell tumors in the endocrine pancreas of mice. Plos One. 4: e8008. PMID 19956728 DOI: 10.1371/Journal.Pone.0008008 |
0.431 |
|
| 2009 |
Feng D, Wei J, Gupta S, McGrath BC, Cavener DR. Acute ablation of PERK results in ER dysfunctions followed by reduced insulin secretion and cell proliferation. Bmc Cell Biology. 10: 61. PMID 19732428 DOI: 10.1186/1471-2121-10-61 |
0.457 |
|
| 2009 |
Gupta S, McGrath B, Cavener DR. Correction: PERK Regulates the Proliferation and Development of Insulin-Secreting Beta-Cell Tumors in the Endocrine Pancreas of Mice Plos One. 4. DOI: 10.1371/annotation/b22a2657-7ce6-471a-8593-8bc8e86e2efa |
0.416 |
|
| 2007 |
Iida K, Li Y, McGrath BC, Frank A, Cavener DR. PERK eIF2 alpha kinase is required to regulate the viability of the exocrine pancreas in mice. Bmc Cell Biology. 8: 38. PMID 17727724 DOI: 10.1186/1471-2121-8-38 |
0.528 |
|
| 2007 |
Iida K, Cox-Foster DL, Yang X, Ko WY, Cavener DR. Expansion and evolution of insect GMC oxidoreductases. Bmc Evolutionary Biology. 7: 75. PMID 17498303 DOI: 10.1186/1471-2148-7-75 |
0.715 |
|
| 2006 |
Zhang W, Feng D, Li Y, Iida K, McGrath B, Cavener DR. PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis. Cell Metabolism. 4: 491-7. PMID 17141632 DOI: 10.1016/j.cmet.2006.11.002 |
0.491 |
|
| 2006 |
Liang SH, Zhang W, McGrath BC, Zhang P, Cavener DR. PERK (eIF2alpha kinase) is required to activate the stress-activated MAPKs and induce the expression of immediate-early genes upon disruption of ER calcium homoeostasis. The Biochemical Journal. 393: 201-9. PMID 16124869 DOI: 10.1042/BJ20050374 |
0.75 |
|
| 2005 |
Owen CR, Kumar R, Zhang P, McGrath BC, Cavener DR, Krause GS. PERK is responsible for the increased phosphorylation of eIF2alpha and the severe inhibition of protein synthesis after transient global brain ischemia. Journal of Neurochemistry. 94: 1235-42. PMID 16000157 DOI: 10.1111/J.1471-4159.2005.03276.X |
0.727 |
|
| 2004 |
Iida K, Cavener DR. Glucose dehydrogenase is required for normal sperm storage and utilization in female Drosophila melanogaster. The Journal of Experimental Biology. 207: 675-81. PMID 14718510 DOI: 10.1242/jeb.00816 |
0.513 |
|
| 2003 |
Li Y, Iida K, O'Neil J, Zhang P, Li S, Frank A, Gabai A, Zambito F, Liang SH, Rosen CJ, Cavener DR. PERK eIF2alpha kinase regulates neonatal growth by controlling the expression of circulating insulin-like growth factor-I derived from the liver. Endocrinology. 144: 3505-13. PMID 12865332 DOI: 10.1210/en.2003-0236 |
0.766 |
|
| 2002 |
Zhang P, McGrath BC, Reinert J, Olsen DS, Lei L, Gill S, Wek SA, Vattem KM, Wek RC, Kimball SR, Jefferson LS, Cavener DR. The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice. Molecular and Cellular Biology. 22: 6681-8. PMID 12215525 DOI: 10.1128/Mcb.22.19.6681-6688.2002 |
0.763 |
|
| 2002 |
Zhang P, McGrath B, Li S, Frank A, Zambito F, Reinert J, Gannon M, Ma K, McNaughton K, Cavener DR. The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas. Molecular and Cellular Biology. 22: 3864-74. PMID 11997520 DOI: 10.1128/Mcb.22.11.3864-3874.2002 |
0.738 |
|
| 2001 |
Kumar R, Azam S, Sullivan JM, Owen C, Cavener DR, Zhang P, Ron D, Harding HP, Chen JJ, Han A, White BC, Krause GS, DeGracia DJ. Brain ischemia and reperfusion activates the eukaryotic initiation factor 2alpha kinase, PERK. Journal of Neurochemistry. 77: 1418-21. PMID 11389192 DOI: 10.1046/J.1471-4159.2001.00387.X |
0.728 |
|
| 2001 |
Keplinger BL, Guo X, Quine J, Feng Y, Cavener DR. Complex organization of promoter and enhancer elements regulate the tissue- and developmental stage-specific expression of the Drosophila melanogaster Gld gene. Genetics. 157: 699-716. PMID 11156990 |
0.758 |
|
| 2000 |
Sood R, Porter AC, Olsen DA, Cavener DR, Wek RC. A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alpha. Genetics. 154: 787-801. PMID 10655230 |
0.572 |
|
| 1998 |
Olsen DS, Jordan B, Chen D, Wek RC, Cavener DR. Isolation of the gene encoding the Drosophila melanogaster homolog of the Saccharomyces cerevisiae GCN2 eIF-2alpha kinase. Genetics. 149: 1495-509. PMID 9649537 |
0.608 |
|
| 1997 |
Qu S, Perlaky SE, Organ EL, Crawford D, Cavener DR. Mutations at the Ser50 residue of translation factor eIF-2alpha dominantly affect developmental rate, body weight, and viability of Drosophila melanogaster. Gene Expression. 6: 349-60. PMID 9495316 |
0.758 |
|
| 1997 |
Ye X, Fong P, Iizuka N, Choate D, Cavener DR. Ultrabithorax and Antennapedia 5' untranslated regions promote developmentally regulated internal translation initiation. Molecular and Cellular Biology. 17: 1714-21. PMID 9032298 |
0.471 |
|
| 1996 |
Keplinger BL, Rabetoy AL, Cavener DR. A somatic reproductive organ enhancer complex activates expression in both the developing and the mature Drosophila reproductive tract. Developmental Biology. 180: 311-23. PMID 8948593 DOI: 10.1006/dbio.1996.0303 |
0.775 |
|
| 1995 |
Duncan RF, Cavener DR, Qu S. Heat shock effects on phosphorylation of protein synthesis initiation factor proteins eIF-4E and eIF-2 alpha in Drosophila. Biochemistry. 34: 2985-97. PMID 7893711 DOI: 10.1021/Bi00009A030 |
0.453 |
|
| 1995 |
Yaich LE, Roodi N, Bailey LR, Verrier CS, Yee CJ, Cavener DR, Parl FF. Analysis of the estrogen receptor (ER) gene, transcript and protein in ER-positive and -negative breast cancer cell lines Endocrine-Related Cancer. 2: 293-309. |
0.759 |
|
| 1994 |
Ye X, Cavener DR. Isolation and characterization of the Drosophila melanogaster gene encoding translation-initiation factor eIF-2 beta. Gene. 142: 271-4. PMID 8194763 DOI: 10.1016/0378-1119(94)90273-9 |
0.391 |
|
| 1994 |
Ross JL, Fong PP, Cavener DR. Correlated evolution of the cis-acting regulatory elements and developmental expression of the Drosophila Gld gene in seven species from the subgroup melanogaster. Developmental Genetics. 15: 38-50. PMID 8187349 DOI: 10.1002/dvg.1020150106 |
0.331 |
|
| 1994 |
Gunaratne P, Ross JL, Zhang Q, Organ EL, Cavener DR. An evolutionarily conserved palindrome in the Drosophila Gld promoter directs tissue-specific expression. Proceedings of the National Academy of Sciences of the United States of America. 91: 2738-42. PMID 8146184 DOI: 10.1073/Pnas.91.7.2738 |
0.655 |
|
| 1994 |
Qu S, Cavener DR. Isolation and characterization of the Drosophila melanogaster eIF-2 alpha gene encoding the alpha subunit of translation initiation factor eIF-2. Gene. 140: 239-42. PMID 8144032 DOI: 10.1016/0378-1119(94)90550-9 |
0.509 |
|
| 1993 |
Quine JA, Gunaratne P, Organ EL, Cavener BA, Cavener DR. Tissue-specific regulatory elements of the Drosophila Gld gene. Mechanisms of Development. 42: 3-13. PMID 8369222 DOI: 10.1016/0925-4773(93)90094-E |
0.773 |
|
| 1992 |
Schiff NM, Feng Y, Quine JA, Krasney PA, Cavener DR. Evolution of the expression of the Gld gene in the reproductive tract of Drosophila. Molecular Biology and Evolution. 9: 1029-49. PMID 1435233 |
0.787 |
|
| 1992 |
Yaich L, Dupont WD, Cavener DR, Parl FF. Analysis of the PvuII restriction fragment-length polymorphism and exon structure of the estrogen receptor gene in breast cancer and peripheral blood. Cancer Research. 52: 77-83. PMID 1345763 |
0.751 |
|
| 1992 |
Schonbaum CP, Organ EL, Qu S, Cavener DR. The Drosophila melanogaster stranded at second (sas) gene encodes a putative epidermal cell surface receptor required for larval development. Developmental Biology. 151: 431-45. PMID 1339334 DOI: 10.1016/0012-1606(92)90183-H |
0.797 |
|
| 1991 |
Foster BD, Cavener DR, Parl FF. Binding analysis of the estrogen receptor to its specific DNA target site in human breast cancer. Cancer Research. 51: 3405-10. PMID 2054780 |
0.43 |
|
| 1991 |
Cavener DR, Krasney PA. Drosophila glucose dehydrogenase and yeast alcohol oxidase are homologous and share N-terminal homology with other flavoenzymes. Molecular Biology and Evolution. 8: 144-50. PMID 2002763 |
0.731 |
|
| 1991 |
Feng Y, Schiff NM, Cavener DR. Organ-specific patterns of gene expression in the reproductive tract of Drosophila are regulated by the sex-determination genes. Developmental Biology. 146: 451-60. PMID 1907583 DOI: 10.1016/0012-1606(91)90246-Y |
0.51 |
|
| 1991 |
Feng Y, Gunter LE, Organ EL, Cavener DR. Translation initiation in Drosophila melanogaster is reduced by mutations upstream of the AUG initiator codon. Molecular and Cellular Biology. 11: 2149-53. PMID 1900921 DOI: 10.1128/Mcb.11.4.2149 |
0.441 |
|
| 1990 |
Cox-Foster DL, Schonbaum CP, Murtha MT, Cavener DR. Developmental expression of the glucose dehydrogenase gene in Drosophila melanogaster. Genetics. 124: 873-80. PMID 2108903 |
0.778 |
|
| 1990 |
Krasney PA, Carr C, Cavener DR. Evolution of the glucose dehydrogenase gene in Drosophila. Molecular Biology and Evolution. 7: 155-77. PMID 2108306 |
0.789 |
|
| 1989 |
Murtha MT, Cavener DR. Ecdysteroid regulation of glucose dehydrogenase and alcohol dehydrogenase gene expression in Drosophila melanogaster. Developmental Biology. 135: 66-73. PMID 2504635 DOI: 10.1016/0012-1606(89)90158-9 |
0.663 |
|
| 1988 |
Cavener D, Feng Y, Foster B, Krasney P, Murtha M, Schonbaum C, Xiao X. The YYRR box: a conserved dipyrimidine-dipurine sequence element in Drosophila and other eukaryotes. Nucleic Acids Research. 16: 3375-90. PMID 3375058 DOI: 10.1093/nar/16.8.3375 |
0.744 |
|
| 1988 |
Whetten R, Organ E, Krasney P, Cox-Foster D, Cavener D. Molecular structure and transformation of the glucose dehydrogenase gene in Drosophila melanogaster. Genetics. 120: 475-84. PMID 3143620 |
0.782 |
|
| 1987 |
Parl FF, Schonbaum CP, Cox DL, Cavener DR. Detection of estrogen receptor mRNA in human uterus. Molecular and Cellular Endocrinology. 52: 235-42. PMID 3653505 DOI: 10.1016/0303-7207(87)90049-9 |
0.756 |
|
| 1986 |
Cavener D, Corbett G, Cox D, Whetten R. Isolation of the eclosion gene cluster and the developmental expression of the Gld gene in Drosophila melanogaster. The Embo Journal. 5: 2939-48. PMID 3024970 DOI: 10.1002/J.1460-2075.1986.Tb04590.X |
0.603 |
|
| 1983 |
Cavener DR, MacIntyre RJ. Biphasic expression and function of glucose dehydrogenase in Drosophila melanogaster. Proceedings of the National Academy of Sciences of the United States of America. 80: 6286-8. PMID 6413974 |
0.601 |
|
| 1982 |
Clegg MT, Cavener DR. Dynamics of correlated genetic systems; VII Demographic aspects of sex-linked transmission ( Drosophila melanogaster). American Naturalist. 120: 108-118. DOI: 10.1086/283972 |
0.511 |
|
| 1981 |
Cavener DR, Clegg MT. MULTIGENIC RESPONSE TO ETHANOL IN DROSOPHILA MELANOGASTER. Evolution; International Journal of Organic Evolution. 35: 1-10. PMID 28563446 DOI: 10.1111/j.1558-5646.1981.tb04853.x |
0.462 |
|
| 1981 |
Cavener DR, Clegg MT. Temporal Stability of Allozyme Frequencies in a Natural Population of DROSOPHILA MELANOGASTER. Genetics. 98: 613-23. PMID 17249103 |
0.492 |
|
| 1981 |
Cavener DR, Clegg MT. Evidence for biochemical and physiological differences between enzyme genotypes in Drosophila melanogaster. Proceedings of the National Academy of Sciences of the United States of America. 78: 4444-7. PMID 6794031 DOI: 10.1073/Pnas.78.7.4444 |
0.504 |
|
| 1978 |
Cavener DR, Clegg MT. Dynamics of correlated genetic systems. IV. Multilocus effects of ethanol stress environments. Genetics. 90: 629-44. PMID 103779 |
0.534 |
|
| 1976 |
Cavener DR, Clegg MT. The genetics of glutamate oxaloacetate transaminase in Drosophila melanogaster. The Journal of Heredity. 67: 313-4. PMID 827557 |
0.479 |
|
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