Iswar Hariharan - Publications

Affiliations: 
Molecular and Cell Biology University of California, Berkeley, Berkeley, CA 
Area:
Mechanisms of control of growth and cell proliferation, Regulation of regenerative growth.

67 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Worley MI, Alexander LA, Hariharan IK. CtBP impedes JNK- and Upd/STAT-driven cell fate misspecifications in regenerating Drosophila imaginal discs. Elife. 7. PMID 29372681 DOI: 10.7554/eLife.30391  0.52
2017 Sumabat TM, Hariharan IK. Ras Brakes for Hippo. Developmental Cell. 42: 561-562. PMID 28950097 DOI: 10.1016/j.devcel.2017.09.009  0.36
2016 Bosch JA, Sumabat TM, Hariharan IK. Persistence of RNAi-Mediated Knockdown in Drosophila Complicates Mosaic Analysis yet Enables Highly Sensitive Lineage Tracing. Genetics. PMID 26984059 DOI: 10.1534/genetics.116.187062  0.36
2016 Harris RE, Setiawan L, Saul J, Hariharan IK. Localized epigenetic silencing of a damage-activated WNT enhancer limits regeneration in mature Drosophila imaginal discs. Elife. 5. PMID 26840050 DOI: 10.7554/eLife.11588  1
2015 Hariharan IK. Organ Size Control: Lessons from Drosophila. Developmental Cell. 34: 255-65. PMID 26267393 DOI: 10.1016/j.devcel.2015.07.012  1
2015 Hariharan IK, Wake DB, Wake MH. Indeterminate Growth: Could It Represent the Ancestral Condition? Cold Spring Harbor Perspectives in Biology. PMID 26216720 DOI: 10.1101/cshperspect.a019174  1
2015 Hariharan IK. Energy stress tames the Hippo pathway. Nature Cell Biology. 17: 362-3. PMID 25812520 DOI: 10.1038/ncb3141  1
2015 Bosch JA, Tran NH, Hariharan IK. CoinFLP: a system for efficient mosaic screening and for visualizing clonal boundaries in Drosophila. Development (Cambridge, England). 142: 597-606. PMID 25605786 DOI: 10.1242/dev.114603  1
2014 Bosch JA, Sumabat TM, Hafezi Y, Pellock BJ, Gandhi KD, Hariharan IK. The Drosophila F-box protein Fbxl7 binds to the protocadherin fat and regulates Dachs localization and Hippo signaling. Elife. 3: e03383. PMID 25107277 DOI: 10.7554/eLife.03383  1
2013 Worley MI, Setiawan L, Hariharan IK. TIE-DYE: a combinatorial marking system to visualize and genetically manipulate clones during development in Drosophila melanogaster. Development (Cambridge, England). 140: 3275-84. PMID 23785055 DOI: 10.1242/dev.096057  1
2013 Kanda H, Nguyen A, Chen L, Okano H, Hariharan IK. The Drosophila ortholog of MLL3 and MLL4, trithorax related, functions as a negative regulator of tissue growth. Molecular and Cellular Biology. 33: 1702-10. PMID 23459941 DOI: 10.1128/MCB.01585-12  1
2012 Worley MI, Setiawan L, Hariharan IK. Regeneration and transdetermination in Drosophila imaginal discs. Annual Review of Genetics. 46: 289-310. PMID 22934642 DOI: 10.1146/annurev-genet-110711-155637  1
2012 Harvey KF, Hariharan IK. The hippo pathway. Cold Spring Harbor Perspectives in Biology. 4: a011288. PMID 22745287 DOI: 10.1101/cshperspect.a011288  1
2012 Hariharan IK. How growth abnormalities delay "puberty" in Drosophila. Science Signaling. 5: pe27. PMID 22715466 DOI: 10.1126/scisignal.2003238  1
2012 Hafezi Y, Bosch JA, Hariharan IK. Differences in levels of the transmembrane protein Crumbs can influence cell survival at clonal boundaries. Developmental Biology. 368: 358-69. PMID 22683826 DOI: 10.1016/j.ydbio.2012.06.001  1
2011 Gerhold AR, Richter DJ, Yu AS, Hariharan IK. Identification and characterization of genes required for compensatory growth in Drosophila. Genetics. 189: 1309-26. PMID 21926302 DOI: 10.1534/genetics.111.132993  1
2010 Reis T, Van Gilst MR, Hariharan IK. A buoyancy-based screen of Drosophila larvae for fat-storage mutants reveals a role for Sir2 in coupling fat storage to nutrient availability. Plos Genetics. 6: e1001206. PMID 21085633 DOI: 10.1371/journal.pgen.1001206  1
2010 Siegrist SE, Haque NS, Chen CH, Hay BA, Hariharan IK. Inactivation of both Foxo and reaper promotes long-term adult neurogenesis in Drosophila. Current Biology : Cb. 20: 643-8. PMID 20346676 DOI: 10.1016/j.cub.2010.01.060  1
2010 Herz HM, Madden LD, Chen Z, Bolduc C, Buff E, Gupta R, Davuluri R, Shilatifard A, Hariharan IK, Bergmann A. The H3K27me3 demethylase dUTX is a suppressor of Notch- and Rb-dependent tumors in Drosophila. Molecular and Cellular Biology. 30: 2485-97. PMID 20212086 DOI: 10.1128/MCB.01633-09  1
2010 Halme A, Cheng M, Hariharan IK. Retinoids regulate a developmental checkpoint for tissue regeneration in Drosophila. Current Biology : Cb. 20: 458-63. PMID 20189388 DOI: 10.1016/j.cub.2010.01.038  1
2009 Smith-Bolton RK, Worley MI, Kanda H, Hariharan IK. Regenerative growth in Drosophila imaginal discs is regulated by Wingless and Myc. Developmental Cell. 16: 797-809. PMID 19531351 DOI: 10.1016/j.devcel.2009.04.015  1
2008 Harvey KF, Mattila J, Sofer A, Bennett FC, Ramsey MR, Ellisen LW, Puig O, Hariharan IK. FOXO-regulated transcription restricts overgrowth of Tsc mutant organs. The Journal of Cell Biology. 180: 691-6. PMID 18299344 DOI: 10.1083/jcb.200710100  1
2007 Pfleger CM, Harvey KF, Yan H, Hariharan IK. Mutation of the gene encoding the ubiquitin activating enzyme ubal causes tissue overgrowth in Drosophila. Fly. 1: 95-105. PMID 18820468  1
2007 Tseng AS, Tapon N, Kanda H, Cigizoglu S, Edelmann L, Pellock B, White K, Hariharan IK. Capicua regulates cell proliferation downstream of the receptor tyrosine kinase/ras signaling pathway. Current Biology : Cb. 17: 728-33. PMID 17398096 DOI: 10.1016/j.cub.2007.03.023  1
2007 Pellock BJ, Buff E, White K, Hariharan IK. The Drosophila tumor suppressors Expanded and Merlin differentially regulate cell cycle exit, apoptosis, and Wingless signaling. Developmental Biology. 304: 102-15. PMID 17258190 DOI: 10.1016/j.ydbio.2006.12.021  1
2006 Hariharan IK. Growth regulation: a beginning for the hippo pathway. Current Biology : Cb. 16: R1037-9. PMID 17174912 DOI: 10.1016/j.cub.2006.11.012  1
2006 Walker JA, Tchoudakova AV, McKenney PT, Brill S, Wu D, Cowley GS, Hariharan IK, Bernards A. Reduced growth of Drosophila neurofibromatosis 1 mutants reflects a non-cell-autonomous requirement for GTPase-Activating Protein activity in larval neurons. Genes & Development. 20: 3311-23. PMID 17114577 DOI: 10.1101/gad.1466806  1
2006 Hariharan IK, Bilder D. Regulation of imaginal disc growth by tumor-suppressor genes in Drosophila. Annual Review of Genetics. 40: 335-61. PMID 16872256 DOI: 10.1146/annurev.genet.39.073003.100738  1
2006 Mills K, Daish T, Harvey KF, Pfleger CM, Hariharan IK, Kumar S. The Drosophila melanogaster Apaf-1 homologue ARK is required for most, but not all, programmed cell death. The Journal of Cell Biology. 172: 809-15. PMID 16533943 DOI: 10.1083/jcb.200512126  1
2005 Moberg KH, Schelble S, Burdick SK, Hariharan IK. Mutations in erupted, the Drosophila ortholog of mammalian tumor susceptibility gene 101, elicit non-cell-autonomous overgrowth. Developmental Cell. 9: 699-710. PMID 16256744 DOI: 10.1016/j.devcel.2005.09.018  1
2005 Delalle I, Pfleger CM, Buff E, Lueras P, Hariharan IK. Mutations in the Drosophila orthologs of the F-actin capping protein alpha- and beta-subunits cause actin accumulation and subsequent retinal degeneration. Genetics. 171: 1757-65. PMID 16143599 DOI: 10.1534/genetics.105.049213  1
2005 Reis T, Hariharan IK. Melting fat away in flies. Cell Metabolism. 2: 82-4. PMID 16098825 DOI: 10.1016/j.cmet.2005.08.002  1
2005 Kwak EL, Moberg KH, Wahrer DC, Quinn JE, Gilmore PM, Graham CA, Hariharan IK, Harkin DP, Haber DA, Bell DW. Infrequent mutations of Archipelago (hAGO, hCDC4, Fbw7) in primary ovarian cancer. Gynecologic Oncology. 98: 124-8. PMID 15913747 DOI: 10.1016/j.ygyno.2005.04.007  1
2005 Hariharan IK. Ras and Rap: are former enemies now friends? Developmental Cell. 8: 303-4. PMID 15737926 DOI: 10.1016/j.devcel.2005.02.006  1
2004 Moberg KH, Mukherjee A, Veraksa A, Artavanis-Tsakonas S, Hariharan IK. The Drosophila F box protein archipelago regulates dMyc protein levels in vivo. Current Biology : Cb. 14: 965-74. PMID 15182669 DOI: 10.1016/j.cub.2004.04.040  1
2003 Moberg KH, Hariharan IK. Big things from a little RNA. Trends in Cell Biology. 13: 455-7. PMID 12946623 DOI: 10.1016/S0962-8924(03)00168-5  1
2003 Harvey KF, Pfleger CM, Hariharan IK. The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis. Cell. 114: 457-67. PMID 12941274 DOI: 10.1016/S0092-8674(03)00557-9  1
2003 Hariharan IK, Haber DA. Yeast, flies, worms, and fish in the study of human disease. The New England Journal of Medicine. 348: 2457-63. PMID 12802034 DOI: 10.1056/NEJMon023158  1
2002 Neufeld TP, Hariharan IK. Regulation of growth and cell proliferation during eye development. Results and Problems in Cell Differentiation. 37: 107-33. PMID 25707072  1
2002 Tseng AS, Hariharan IK. An overexpression screen in Drosophila for genes that restrict growth or cell-cycle progression in the developing eye. Genetics. 162: 229-43. PMID 12242236  1
2002 Tapon N, Harvey KF, Bell DW, Wahrer DC, Schiripo TA, Haber D, Hariharan IK. salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines. Cell. 110: 467-78. PMID 12202036 DOI: 10.1016/S0092-8674(02)00824-3  1
2001 Tapon N, Moberg KH, Hariharan IK. The coupling of cell growth to the cell cycle. Current Opinion in Cell Biology. 13: 731-7. PMID 11698190 DOI: 10.1016/S0955-0674(00)00284-2  1
2001 Moberg KH, Bell DW, Wahrer DC, Haber DA, Hariharan IK. Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines. Nature. 413: 311-6. PMID 11565033 DOI: 10.1038/35095068  1
2001 Bernards A, Hariharan IK. Of flies and men--studying human disease in Drosophila. Current Opinion in Genetics & Development. 11: 274-8. PMID 11377963 DOI: 10.1016/S0959-437X(00)00190-8  1
2001 Tapon N, Ito N, Dickson BJ, Treisman JE, Hariharan IK. The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation. Cell. 105: 345-55. PMID 11348591 DOI: 10.1016/S0092-8674(01)00332-4  1
2000 de Nooij JC, Graber KH, Hariharan IK. Expression of the cyclin-dependent kinase inhibitor Dacapo is regulated by cyclin E. Mechanisms of Development. 97: 73-83. PMID 11025208 DOI: 10.1016/S0925-4773(00)00435-4  1
2000 Fortini ME, Skupski MP, Boguski MS, Hariharan IK. A survey of human disease gene counterparts in the Drosophila genome. The Journal of Cell Biology. 150: F23-30. PMID 10908582  1
2000 Rubin GM, Yandell MD, Wortman JR, Gabor Miklos GL, Nelson CR, Hariharan IK, Fortini ME, Li PW, Apweiler R, Fleischmann W, Cherry JM, Henikoff S, Skupski MP, Misra S, Ashburner M, et al. Comparative genomics of the eukaryotes. Science (New York, N.Y.). 287: 2204-15. PMID 10731134 DOI: 10.1126/science.287.5461.2204  1
1999 Asha H, de Ruiter ND, Wang MG, Hariharan IK. The Rap1 GTPase functions as a regulator of morphogenesis in vivo. The Embo Journal. 18: 605-15. PMID 9927420 DOI: 10.1093/emboj/18.3.605  1
1997 Li Q, Hariharan IK, Chen F, Huang Y, Fischer JA. Genetic interactions with Rap1 and Ras1 reveal a second function for the fat facets deubiquitinating enzyme in Drosophila eye development. Proceedings of the National Academy of Sciences of the United States of America. 94: 12515-20. PMID 9356481 DOI: 10.1073/pnas.94.23.12515  1
1997 Chen F, Barkett M, Ram KT, Quintanilla A, Hariharan IK. Biological characterization of Drosophila Rapgap1, a GTPase activating protein for Rap1. Proceedings of the National Academy of Sciences of the United States of America. 94: 12485-90. PMID 9356476  1
1997 The I, Hannigan GE, Cowley GS, Reginald S, Zhong Y, Gusella JF, Hariharan IK, Bernards A. Rescue of a Drosophila NF1 mutant phenotype by protein kinase A. Science (New York, N.Y.). 276: 791-4. PMID 9115203 DOI: 10.1126/science.276.5313.791  1
1996 de Nooij JC, Letendre MA, Hariharan IK. A cyclin-dependent kinase inhibitor, Dacapo, is necessary for timely exit from the cell cycle during Drosophila embryogenesis. Cell. 87: 1237-47. PMID 8980230 DOI: 10.1016/S0092-8674(00)81819-X  1
1995 Hariharan IK, Hu KQ, Asha H, Quintanilla A, Ezzell RM, Settleman J. Characterization of rho GTPase family homologues in Drosophila melanogaster: overexpressing Rho1 in retinal cells causes a late developmental defect. The Embo Journal. 14: 292-302. PMID 7835340  1
1995 de Nooij JC, Hariharan IK. Uncoupling cell fate determination from patterned cell division in the Drosophila eye. Science (New York, N.Y.). 270: 983-5. PMID 7481802  1
1993 Heberlein U, Hariharan IK, Rubin GM. Star is required for neuronal differentiation in the Drosophila retina and displays dosage-sensitive interactions with Ras1. Developmental Biology. 160: 51-63. PMID 8224548 DOI: 10.1006/dbio.1993.1285  1
1991 Hariharan IK, Carthew RW, Rubin GM. The Drosophila roughened mutation: activation of a rap homolog disrupts eye development and interferes with cell determination. Cell. 67: 717-22. PMID 1934069 DOI: 10.1016/0092-8674(91)90066-8  1
1991 Hariharan IK, Chuang PT, Rubin GM. Cloning and characterization of a receptor-class phosphotyrosine phosphatase gene expressed on central nervous system axons in Drosophila melanogaster. Proceedings of the National Academy of Sciences of the United States of America. 88: 11266-70. PMID 1662390  1
1990 Elefanty AG, Hariharan IK, Cory S. bcr-abl, the hallmark of chronic myeloid leukaemia in man, induces multiple haemopoietic neoplasms in mice. The Embo Journal. 9: 1069-78. PMID 1691092  1
1989 Hariharan IK, Harris AW, Crawford M, Abud H, Webb E, Cory S, Adams JM. A bcr-v-abl oncogene induces lymphomas in transgenic mice. Molecular and Cellular Biology. 9: 2798-805. PMID 2789335  1
1989 Hariharan IK, Johnson GR, Gonda TJ, Metcalf D, Adams JM, Cory S. Analysis of the leukemogenic properties of the bcr-v-abl and GM-CSF genes using a new retroviral vector. Current Topics in Microbiology and Immunology. 149: 99-107. PMID 2659286  1
1989 Adams JM, Harris AW, Langdon WY, Klinken SP, Kongsuwan K, Alexander WS, Hariharan I, Vaux D, Rosenbaum H, Crawford M. Lymphoid neoplasia and the control of haemopoietic differentiation. Ciba Foundation Symposium. 142: 54-64; discussion 65. PMID 2568245  1
1988 Harris AW, Langdon WY, Alexander WS, Hariharan IK, Rosenbaum H, Vaux D, Webb E, Bernard O, Crawford M, Abud H. Transgenic mouse models for hematopoietic tumorigenesis. Current Topics in Microbiology and Immunology. 141: 82-93. PMID 3215058  1
1988 Hariharan IK. A vector for inducible production of retrovirus. Nucleic Acids Research. 16: 9345. PMID 3174456  1
1988 Hariharan IK, Adams JM, Cory S. bcr-abl oncogene renders myeloid cell line factor independent: potential autocrine mechanism in chronic myeloid leukemia. Oncogene Research. 3: 387-99. PMID 3147434  1
1987 Hariharan IK, Gough N. Activation of a gene activator. Immunology Today. 8: 175-6. PMID 25290215 DOI: 10.1016/0167-5699(87)90033-8  1
1987 Hariharan IK, Adams JM. cDNA sequence for human bcr, the gene that translocates to the abl oncogene in chronic myeloid leukaemia. The Embo Journal. 6: 115-9. PMID 3107980  1
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