Marc Therrien - Publications


50 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Lavoie H, Therrien M. Regulation of RAF protein kinases in ERK signalling. Nature Reviews. Molecular Cell Biology. 16: 281-98. PMID 25907612 DOI: 10.1038/nrm3979  1
2015 Thevakumaran N, Lavoie H, Critton DA, Tebben A, Marinier A, Sicheri F, Therrien M. Crystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation. Nature Structural & Molecular Biology. 22: 37-43. PMID 25437913 DOI: 10.1038/nsmb.2924  1
2014 Lavoie H, Li JJ, Thevakumaran N, Therrien M, Sicheri F. Dimerization-induced allostery in protein kinase regulation. Trends in Biochemical Sciences. 39: 475-86. PMID 25220378 DOI: 10.1016/j.tibs.2014.08.004  1
2014 Baril C, Lefrançois M, Sahmi M, Knævelsrud H, Therrien M. Apical accumulation of the Sevenless receptor tyrosine kinase during Drosophila eye development is promoted by the small GTPase Rap1. Genetics. 197: 1237-50. PMID 24899161 DOI: 10.1534/genetics.114.166272  1
2014 Mashtalir N, Daou S, Barbour H, Sen NN, Gagnon J, Hammond-Martel I, Dar HH, Therrien M, Affar el B. Autodeubiquitination protects the tumor suppressor BAP1 from cytoplasmic sequestration mediated by the atypical ubiquitin ligase UBE2O. Molecular Cell. 54: 392-406. PMID 24703950 DOI: 10.1016/j.molcel.2014.03.002  1
2014 Ashton-Beaucage D, Udell CM, Gendron P, Sahmi M, Lefrançois M, Baril C, Guenier AS, Duchaine J, Lamarre D, Lemieux S, Therrien M. A functional screen reveals an extensive layer of transcriptional and splicing control underlying RAS/MAPK signaling in Drosophila. Plos Biology. 12: e1001809. PMID 24643257 DOI: 10.1371/journal.pbio.1001809  1
2013 Lavoie H, Thevakumaran N, Gavory G, Li JJ, Padeganeh A, Guiral S, Duchaine J, Mao DY, Bouvier M, Sicheri F, Therrien M. Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization. Nature Chemical Biology. 9: 428-36. PMID 23685672 DOI: 10.1038/nchembio.1257  1
2012 Therrien M, Colloud F, Begon M. Effect of stroke rate on paddle tip path in kayaking Movement and Sports Sciences - Science Et Motricite. 75: 113-120. DOI: 10.1051/sm/2011156  1
2011 Lavoie H, Therrien M. Cancer: A drug-resistant duo. Nature. 480: 329-30. PMID 22170679 DOI: 10.1038/480329a  1
2011 Ashton-Beaucage D, Therrien M. The exon junction complex: a splicing factor for long intron containing transcripts? Fly. 5: 224-33. PMID 21478676  1
2011 Udell CM, Rajakulendran T, Sicheri F, Therrien M. Mechanistic principles of RAF kinase signaling. Cellular and Molecular Life Sciences : Cmls. 68: 553-65. PMID 20820846 DOI: 10.1007/s00018-010-0520-6  1
2011 Ashton-Beaucage D, Therrien M. The exon junction complex a splicing factor for long intron containing transcripts? Fly. 5: 1-10.  1
2010 Ashton-Beaucage D, Therrien M. [The greater RTK/RAS/ERK signalling pathway: how genetics has helped piece together a signalling network]. MéDecine Sciences : M/S. 26: 1067-73. PMID 21187046 DOI: 10.1051/medsci/201026121067  1
2010 Caron E, Ghosh S, Matsuoka Y, Ashton-Beaucage D, Therrien M, Lemieux S, Perreault C, Roux PP, Kitano H. A comprehensive map of the mTOR signaling network. Molecular Systems Biology. 6: 453. PMID 21179025 DOI: 10.1038/msb.2010.108  1
2010 Ashton-Beaucage D, Udell CM, Lavoie H, Baril C, Lefrançois M, Chagnon P, Gendron P, Caron-Lizotte O, Bonneil E, Thibault P, Therrien M. The exon junction complex controls the splicing of MAPK and other long intron-containing transcripts in Drosophila. Cell. 143: 251-62. PMID 20946983 DOI: 10.1016/j.cell.2010.09.014  1
2010 Lavoie H, Therrien M. [It takes two RAFs to tango]. MéDecine Sciences : M/S. 26: 459-60. PMID 20510139 DOI: 10.1051/medsci/2010265459  1
2010 Lavigne M, Therrien M, Nantel J, Roy A, Prince F, Vendittoli PA. The John Charnley Award: The functional outcome of hip resurfacing and large-head THA is the same: a randomized, double-blind study. Clinical Orthopaedics and Related Research. 468: 326-36. PMID 19543863 DOI: 10.1007/s11999-009-0938-z  1
2009 Rajakulendran T, Sahmi M, Lefrançois M, Sicheri F, Therrien M. A dimerization-dependent mechanism drives RAF catalytic activation. Nature. 461: 542-5. PMID 19727074 DOI: 10.1038/nature08314  1
2009 Lacoste M, Therrien M, Prince F. Stability of children with cerebral palsy in their wheelchair seating: perceptions of parents and therapists. Disability and Rehabilitation. Assistive Technology. 4: 143-50. PMID 19378209 DOI: 10.1080/17483100802362036  1
2009 Baril C, Sahmi M, Ashton-Beaucage D, Stronach B, Therrien M. The PP2C Alphabet is a negative regulator of stress-activated protein kinase signaling in Drosophila. Genetics. 181: 567-79. PMID 19064708 DOI: 10.1534/genetics.108.096461  1
2008 Rajakulendran T, Sahmi M, Kurinov I, Tyers M, Therrien M, Sicheri F. CNK and HYP form a discrete dimer by their SAM domains to mediate RAF kinase signaling. Proceedings of the National Academy of Sciences of the United States of America. 105: 2836-41. PMID 18287031 DOI: 10.1073/pnas.0709705105  1
2007 Clapéron A, Therrien M. KSR and CNK: two scaffolds regulating RAS-mediated RAF activation. Oncogene. 26: 3143-58. PMID 17496912 DOI: 10.1038/sj.onc.1210408  1
2006 Lacoste M, Therrien M, Côté JN, Shrier I, Labelle H, Prince F. Assessment of seated postural control in children: comparison of a force platform versus a pressure mapping system. Archives of Physical Medicine and Rehabilitation. 87: 1623-9. PMID 17141643 DOI: 10.1016/j.apmr.2006.08.344  1
2006 Douziech M, Sahmi M, Laberge G, Therrien M. A KSR/CNK complex mediated by HYP, a novel SAM domain-containing protein, regulates RAS-dependent RAF activation in Drosophila. Genes & Development. 20: 807-19. PMID 16600912 DOI: 10.1101/gad.1390406  1
2006 Baril C, Therrien M. Alphabet, a Ser/Thr phosphatase of the protein phosphatase 2C family, negatively regulates RAS/MAPK signaling in Drosophila. Developmental Biology. 294: 232-45. PMID 16600208 DOI: 10.1016/j.ydbio.2006.02.046  1
2005 Laberge G, Douziech M, Therrien M. Src42 binding activity regulates Drosophila RAF by a novel CNK-dependent derepression mechanism. The Embo Journal. 24: 487-98. PMID 15660123 DOI: 10.1038/sj.emboj.7600558  1
2003 Douziech M, Roy F, Laberge G, Lefrançois M, Armengod AV, Therrien M. Bimodal regulation of RAF by CNK in Drosophila. The Embo Journal. 22: 5068-78. PMID 14517245 DOI: 10.1093/emboj/cdg506  1
2002 Roy F, Therrien M. MAP kinase module: the Ksr connection. Current Biology : Cb. 12: R325-7. PMID 12007434 DOI: 10.1016/S0960-9822(02)00831-X  1
2002 Roy F, Laberge G, Douziech M, Ferland-McCollough D, Therrien M. KSR is a scaffold required for activation of the ERK/MAPK module. Genes & Development. 16: 427-38. PMID 11850406 DOI: 10.1101/gad.962902  1
2000 Therrien M, Morrison DK, Wong AM, Rubin GM. A genetic screen for modifiers of a kinase suppressor of Ras-dependent rough eye phenotype in Drosophila. Genetics. 156: 1231-42. PMID 11063697  1
1999 Therrien M, Wong AM, Kwan E, Rubin GM. Functional analysis of CNK in RAS signaling. Proceedings of the National Academy of Sciences of the United States of America. 96: 13259-63. PMID 10557308 DOI: 10.1073/pnas.96.23.13259  1
1999 Cacace AM, Michaud NR, Therrien M, Mathes K, Copeland T, Rubin GM, Morrison DK. Identification of constitutive and ras-inducible phosphorylation sites of KSR: implications for 14-3-3 binding, mitogen-activated protein kinase binding, and KSR overexpression. Molecular and Cellular Biology. 19: 229-40. PMID 9858547  1
1998 Therrien M, Wong AM, Rubin GM. CNK, a RAF-binding multidomain protein required for RAS signaling. Cell. 95: 343-53. PMID 9814705 DOI: 10.1016/S0092-8674(00)81766-3  1
1997 Rubin GM, Chang HC, Karim F, Laverty T, Michaud NR, Morrison DK, Rebay I, Tang A, Therrien M, Wassarman DA. Signal transduction downstream from Ras in Drosophila. Cold Spring Harbor Symposia On Quantitative Biology. 62: 347-52. PMID 9598368  1
1997 Michaud NR, Therrien M, Cacace A, Edsall LC, Spiegel S, Rubin GM, Morrison DK. KSR stimulates Raf-1 activity in a kinase-independent manner. Proceedings of the National Academy of Sciences of the United States of America. 94: 12792-6. PMID 9371754 DOI: 10.1073/pnas.94.24.12792  1
1997 Wassarman DA, Therrien M. Ras1-Mediated Photoreceptor Development in Drosophila Advances in Developmental Biology (1992). 5: 1-41. DOI: 10.1016/S1566-3116(08)60034-1  1
1996 Therrien M, Michaud NR, Rubin GM, Morrison DK. KSR modulates signal propagation within the MAPK cascade. Genes & Development. 10: 2684-95. PMID 8946910  1
1996 Karim FD, Chang HC, Therrien M, Wassarman DA, Laverty T, Rubin GM. A screen for genes that function downstream of Ras1 during Drosophila eye development. Genetics. 143: 315-29. PMID 8722784  1
1996 Lamonerie T, Tremblay JJ, Lanctôt C, Therrien M, Gauthier Y, Drouin J. Ptx1, a bicoid-related homeo box transcription factor involved in transcription of the pro-opiomelanocortin gene. Genes & Development. 10: 1284-95. PMID 8675014  1
1996 Wassarman DA, Solomon NM, Chang HC, Karim FD, Therrien M, Rubin GM. Protein phosphatase 2A positively and negatively regulates Ras1-mediated photoreceptor development in Drosophila. Genes & Development. 10: 272-8. PMID 8595878  1
1995 Therrien M, Chang HC, Solomon NM, Karim FD, Wassarman DA, Rubin GM. KSR, a novel protein kinase required for RAS signal transduction. Cell. 83: 879-88. PMID 8521512 DOI: 10.1016/0092-8674(95)90204-X  1
1995 Chang HC, Solomon NM, Wassarman DA, Karim FD, Therrien M, Rubin GM, Wolff T. phyllopod functions in the fate determination of a subset of photoreceptors in Drosophila. Cell. 80: 463-72. PMID 7888014 DOI: 10.1016/0092-8674(95)90497-2  1
1995 Wassarman DA, Therrien M, Rubin GM. The Ras signaling pathway in Drosophila. Current Opinion in Genetics & Development. 5: 44-50. PMID 7749324 DOI: 10.1016/S0959-437X(95)90052-7  1
1994 Fenrick R, Babinski K, McNicoll N, Therrien M, Drouin J, De Léan A. Cloning and functional expression of the bovine natriuretic peptide receptor-B (natriuretic factor R1c subtype. Molecular and Cellular Biochemistry. 137: 173-82. PMID 7845391 DOI: 10.1007/BF00944079  1
1994 Chang HC, Karim FD, O'Neill EM, Rebay I, Solomon NM, Therrien M, Wassarman DA, Wolff T, Rubin GM. Ras signal transduction pathway in Drosophila eye development. Cold Spring Harbor Symposia On Quantitative Biology. 59: 147-53. PMID 7587064  1
1993 Therrien M, Drouin J. Molecular determinants for cell specificity and glucocorticoid repression of the proopiomelanocortin gene. Annals of the New York Academy of Sciences. 680: 663-71. PMID 8512237  1
1993 Therrien M, Drouin J. Cell-specific helix-loop-helix factor required for pituitary expression of the pro-opiomelanocortin gene. Molecular and Cellular Biology. 13: 2342-53. PMID 8455616  1
1991 Therrien M, Drouin J. Pituitary pro-opiomelanocortin gene expression requires synergistic interactions of several regulatory elements. Molecular and Cellular Biology. 11: 3492-503. PMID 2046665  1
1990 Drouin J, Therrien M, Sun YL, Mullick A, Nemer M. Cell specificity and glucocorticoid repression of POMC gene transcription New Leads in Opioid Research: Proceedings of the International Narcotics Research Conference. Ics914. 109.  1
1989 Drouin J, Nemer M, Charron J, Gagner JP, Jeannotte L, Sun YL, Therrien M, Tremblay Y. Tissue-specific activity of the pro-opiomelanocortin (POMC) gene and repression by glucocorticoids. Genome / National Research Council Canada = GéNome / Conseil National De Recherches Canada. 31: 510-9. PMID 2698828  1
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