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Sarah M. McWhirter, Ph.D. - Publications

Affiliations: 
2000 University of California, Berkeley, Berkeley, CA, United States 
Area:
host-pathogen interactions, motions in proteins
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33 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Nicolai CJ, Wolf N, Chang IC, Kirn G, Marcus A, Ndubaku CO, McWhirter SM, Raulet DH. NK cells mediate clearance of CD8 T cell-resistant tumors in response to STING agonists. Science Immunology. 5. PMID 32198222 DOI: 10.1126/Sciimmunol.Aaz2738  0.422
2020 Deng W, Desbien AL, Gauthier KS, Reiner G, Corrales L, Schroeder T, Glickman LH, Surh NH, Francica B, Leong JJ, Metchette K, Zheng L, Cho C, Feng Y, McKenna JM, ... ... McWhirter SM, et al. Abstract PR09: ADU-S100 (MIW815) synergizes with checkpoint blockade to elicit an antitumor CD8+ T-cell response to control distal tumors Cancer Immunology Research. 8. DOI: 10.1158/2326-6074.Tumimm18-Pr09  0.392
2019 Sivick KE, Desbien AL, Glickman LH, Reiner GL, Corrales L, Surh NH, Hudson TE, Vu UT, Francica BJ, Banda T, Katibah GE, Kanne DB, Leong JJ, Metchette K, Bruml JR, ... ... McWhirter SM, et al. Magnitude of Therapeutic STING Activation Determines CD8 T Cell-Mediated Anti-tumor Immunity. Cell Reports. 29: 785-789. PMID 31618645 DOI: 10.1016/j.celrep.2019.09.089  0.325
2019 Luteijn RD, Zaver SA, Gowen BG, Wyman SK, Garelis NE, Onia L, McWhirter SM, Katibah GE, Corn JE, Woodward JJ, Raulet DH. SLC19A1 transports immunoreactive cyclic dinucleotides. Nature. 573: 434-438. PMID 31511694 DOI: 10.1038/S41586-019-1553-0  0.379
2019 Corrales L, Desbien AL, Gauthier KES, Deng W, Schroeder T, Reiner GL, Surh N, Francica B, Metchette K, Ndubaku CO, McKenna JM, Feng Y, Zheng L, Bender SL, Cho CY, ... ... McWhirter SM, et al. Abstract 1202: Tumor cell intrinsic STING signaling demonstrates minimal contribution to the anti-tumor response elicited by the STING agonist ADU-S100 (MIW815) Cancer Research. 79: 1202-1202. DOI: 10.1158/1538-7445.Am2019-1202  0.387
2018 Sivick KE, Desbien AL, Glickman LH, Reiner GL, Corrales L, Surh NH, Hudson TE, Vu UT, Francica BJ, Banda T, Katibah GE, Kanne DB, Leong JJ, Metchette K, Bruml JR, ... ... McWhirter SM, et al. Magnitude of Therapeutic STING Activation Determines CD8 T Cell-Mediated Anti-tumor Immunity. Cell Reports. 25: 3074-3085.e5. PMID 30540940 DOI: 10.1016/J.Celrep.2018.11.047  0.419
2018 Desbien AL, Gauthier KS, Corrales L, Reiner G, Glickman LH, Katibah G, Hudson TE, Vu U, Surh NH, Francica B, Deng W, Kanne DB, Leong JJ, Ndubaku C, Metchette K, ... ... McWhirter SM, et al. Abstract 631: Intratumoral activation of STING with a synthetic cyclic dinucleotide elicits antitumor CD8 T-cell immunity that effectively combines with checkpoint inhibitors Cancer Research. 78: 631-631. DOI: 10.1158/1538-7445.Am2018-631  0.427
2018 Hendriks M, Kreijtz J, Vink P, Hulsik DL, Lodewijks I, Bertens A, Crommert Jvd, Habraken M, Janssen W, Stammen-Vogelzang J, Gardner O, Deng W, Leong M, McWhirter S, Eenennaam Hv, et al. Abstract 1702: Assessment of pharmacology and toxicology of anti-CTLA-4 antibody (ADU-1604) in non-human primates and evaluation of local anti-CTLA-4 application Cancer Research. 78: 1702-1702. DOI: 10.1158/1538-7445.Am2018-1702  0.338
2017 Sivick KE, Surh NH, Desbien AL, Grewal EP, Katibah GE, McWhirter SM, Dubensky TW. Comment on "The Common R71H-G230A-R293Q Human TMEM173 Is a Null Allele". Journal of Immunology (Baltimore, Md. : 1950). 198: 4183-4185. PMID 28533276 DOI: 10.4049/Jimmunol.1700294  0.362
2016 Corrales L, McWhirter SM, Dubensky TW, Gajewski TF. The host STING pathway at the interface of cancer and immunity. The Journal of Clinical Investigation. 126: 2404-2411. PMID 27367184 DOI: 10.1172/JCI86892  0.316
2016 McWhirter SM, Glickman LH, Desbien T, Gauthier KS, Kanne D, Kasibhatla S, Li J, Pferdekamper AC, Katibah G, Lemmens E, Corrales L, Leong M, Ndubaku C, Leong J, Sung L, et al. Abstract B020: STING activation in the tumor microenvironment using a synthetic human STING-activating cyclic dinucleotide induces potent antitumor immunity Cancer Immunology Research. 4. DOI: 10.1158/2326-6066.Imm2016-B020  0.422
2016 Glickman LH, Corrales L, Kanne DB, Kasibhatla S, Li J, Pferdekamper AMC, Gauthier KS, Katibah GE, Leong JJ, Sung L, Metchette K, Deng W, Desbien AL, Ndubaku C, Zheng L, ... ... McWhirter SM, et al. Abstract SY39-02: Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity Cancer Research. 76. DOI: 10.1158/1538-7445.Am2016-Sy39-02  0.435
2016 Glickman LH, Kanne DB, Kasibhatla S, Li J, Pferdekamper AC, Gauthier KS, Deng W, Desbien AL, Katibah GE, Leong JJ, Sung L, Metchette K, Ndubaku C, Zheng L, Cho C, ... ... McWhirter SM, et al. Abstract 1445: STING activation in the tumor microenvironment with a synthetic human STING-activating cyclic dinucleotide leads to potent anti-tumor immunity Cancer Research. 76: 1445-1445. DOI: 10.1158/1538-7445.Am2016-1445  0.422
2015 Fu J, Kanne DB, Leong M, Glickman LH, McWhirter SM, Lemmens E, Mechette K, Leong JJ, Lauer P, Liu W, Sivick KE, Zeng Q, Soares KC, Zheng L, Portnoy DA, et al. STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade. Science Translational Medicine. 7: 283ra52. PMID 25877890 DOI: 10.1126/Scitranslmed.Aaa4306  0.321
2015 Glickman LH, Kanne DB, Gauthier KE, Katibah GE, Leong JJ, Metchette K, Dubensky TW, McWhirter SM. Abstract 4272: Potentin situcancer immunotherapy with synthetic human STING-activating cyclic dinucleotides Cancer Research. 75: 4272-4272. DOI: 10.1158/1538-7445.Am2015-4272  0.412
2014 Corrales L, Glickman LH, McWhirter SM, Kanne DB, Sivick KE, Lemmens E, Leong JJ, Metchette K, Dubensky TW, Gajewski T. Direct activation of STING in the tumor microenvironment with synthetic cyclic dinucleotide derivatives leads to potent and systemic tumor-specific immunity Journal For Immunotherapy of Cancer. 2. DOI: 10.1186/2051-1426-2-S3-O10  0.41
2014 Glickman LH, Kanne DB, McWhirter SM, Leong ML, Lemmens EE, Metchette K, Vance RE, Pardoll DM, Dubensky TW. Abstract 2566: Activation of tumor-initiated T cell priming and tumor destruction with potent STING-activating cyclic dinucleotide derivatives Cancer Research. 74: 2566-2566. DOI: 10.1158/1538-7445.Am2014-2566  0.431
2013 Chow KT, Schulz D, McWhirter SM, Schlissel MS. Gfi1 and gfi1b repress rag transcription in plasmacytoid dendritic cells in vitro. Plos One. 8: e75891. PMID 24086657 DOI: 10.1371/Journal.Pone.0075891  0.309
2013 Chow KT, Timblin GA, McWhirter SM, Schlissel MS. MK5 activates Rag transcription via Foxo1 in developing B cells. The Journal of Experimental Medicine. 210: 1621-34. PMID 23878308 DOI: 10.1084/Jem.20130498  0.341
2012 Schulz D, Vassen L, Chow KT, McWhirter SM, Amin RH, Möröy T, Schlissel MS. Gfi1b negatively regulates Rag expression directly and via the repression of FoxO1. The Journal of Experimental Medicine. 209: 187-99. PMID 22201127 DOI: 10.1084/Jem.20110645  0.324
2010 Monroe KM, McWhirter SM, Vance RE. Induction of type I interferons by bacteria. Cellular Microbiology. 12: 881-90. PMID 20482555 DOI: 10.1111/J.1462-5822.2010.01478.X  0.334
2009 Monroe KM, McWhirter SM, Vance RE. Identification of host cytosolic sensors and bacterial factors regulating the type I interferon response to Legionella pneumophila. Plos Pathogens. 5: e1000665. PMID 19936053 DOI: 10.1371/Journal.Ppat.1000665  0.315
2009 McWhirter SM, Barbalat R, Monroe KM, Fontana MF, Hyodo M, Joncker NT, Ishii KJ, Akira S, Colonna M, Chen ZJ, Fitzgerald KA, Hayakawa Y, Vance RE. A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP. The Journal of Experimental Medicine. 206: 1899-911. PMID 19652017 DOI: 10.1084/Jem.20082874  0.371
2007 Panne D, McWhirter SM, Maniatis T, Harrison SC. Interferon regulatory factor 3 is regulated by a dual phosphorylation-dependent switch. The Journal of Biological Chemistry. 282: 22816-22. PMID 17526488 DOI: 10.1074/Jbc.M703019200  0.331
2007 Tenoever BR, Ng SL, Chua MA, McWhirter SM, García-Sastre A, Maniatis T. Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity. Science (New York, N.Y.). 315: 1274-8. PMID 17332413 DOI: 10.1126/Science.1136567  0.376
2005 McWhirter SM, Tenoever BR, Maniatis T. Connecting mitochondria and innate immunity. Cell. 122: 645-7. PMID 16143094 DOI: 10.1016/J.Cell.2005.08.026  0.316
2004 McWhirter SM, Fitzgerald KA, Rosains J, Rowe DC, Golenbock DT, Maniatis T. IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts Proceedings of the National Academy of Sciences of the United States of America. 101: 233-238. PMID 14679297 DOI: 10.1073/Pnas.2237236100  0.393
2003 Fitzgerald KA, McWhirter SM, Faia KL, Rowe DC, Latz E, Golenbock DT, Coyle AJ, Liao SM, Maniatis T. IKKE and TBKI are essential components of the IRF3 signalling pathway Nature Immunology. 4: 491-496. PMID 12692549 DOI: 10.1038/Ni921  0.396
2001 Baniecki ML, McGrath WJ, McWhirter SM, Li C, Toledo DL, Pellicena P, Barnard DL, Thorn KS, Mangel WF. Interaction of the human adenovirus proteinase with its 11-amino acid cofactor pVIc. Biochemistry. 40: 12349-56. PMID 11591154 DOI: 10.1021/Bi0109008  0.323
1999 McWhirter SM, Pullen SS, Werneburg BG, Labadia ME, Ingraham RH, Crute JJ, Kehry MR, Alber T. Structural and biochemical analysis of signal transduction by the TRAF family of adapter proteins. Cold Spring Harbor Symposia On Quantitative Biology. 64: 551-62. PMID 11232332 DOI: 10.1101/Sqb.1999.64.551  0.522
1999 Pullen SS, Labadia ME, Ingraham RH, McWhirter SM, Everdeen DS, Alber T, Crute JJ, Kehry MR. High-affinity interactions of tumor necrosis factor receptor-associated factors (TRAFs) and CD40 require TRAF trimerization and CD40 multimerization. Biochemistry. 38: 10168-77. PMID 10433725 DOI: 10.1021/Bi9909905  0.592
1999 McWhirter SM, Pullen SS, Holton JM, Crute JJ, Kehry MR, Alber T. Crystallographic analysis of CD40 recognition and signaling by human TRAF2. Proceedings of the National Academy of Sciences of the United States of America. 96: 8408-13. PMID 10411888 DOI: 10.1073/Pnas.96.15.8408  0.63
1999 Hershey PE, McWhirter SM, Gross JD, Wagner G, Alber T, Sachs AB. The Cap-binding protein eIF4E promotes folding of a functional domain of yeast translation initiation factor eIF4G1. The Journal of Biological Chemistry. 274: 21297-304. PMID 10409688 DOI: 10.1074/Jbc.274.30.21297  0.549
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