Tim Hoey - Publications


66 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Yen WC, Fischer MM, Axelrod F, Bond C, Cain J, Cancilla B, Henner WR, Meisner R, Sato A, Shah J, Tang T, Wallace B, Wang M, Zhang C, Kapoun AM, ... ... Hoey T, et al. Targeting Notch signaling with a Notch2/Notch3 antagonist (tarextumab) inhibits tumor growth and decreases tumor-initiating cell frequency. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 21: 2084-95. PMID 25934888 DOI: 10.1158/1078-0432.CCR-14-2808  1
2014 Pastò A, Serafin V, Pilotto G, Lago C, Bellio C, Trusolino L, Bertotti A, Hoey T, Plateroti M, Esposito G, Pinazza M, Agostini M, Nitti D, Amadori A, Indraccolo S. NOTCH3 signaling regulates MUSASHI-1 expression in metastatic colorectal cancer cells. Cancer Research. 74: 2106-18. PMID 24525742 DOI: 10.1158/0008-5472.CAN-13-2022  1
2014 Agnusdei V, Minuzzo S, Frasson C, Grassi A, Axelrod F, Satyal S, Gurney A, Hoey T, Seganfreddo E, Basso G, Valtorta S, Moresco RM, Amadori A, Indraccolo S. Therapeutic antibody targeting of Notch1 in T-acute lymphoblastic leukemia xenografts. Leukemia. 28: 278-88. PMID 23774673 DOI: 10.1038/leu.2013.183  1
2013 Zhang Y, Morris JP, Yan W, Schofield HK, Gurney A, Simeone DM, Millar SE, Hoey T, Hebrok M, Pasca di Magliano M. Canonical wnt signaling is required for pancreatic carcinogenesis. Cancer Research. 73: 4909-22. PMID 23761328 DOI: 10.1158/0008-5472.CAN-12-4384  1
2012 Yen WC, Fischer MM, Hynes M, Wu J, Kim E, Beviglia L, Yeung VP, Song X, Kapoun AM, Lewicki J, Gurney A, Simeone DM, Hoey T. Anti-DLL4 has broad spectrum activity in pancreatic cancer dependent on targeting DLL4-Notch signaling in both tumor and vasculature cells. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: 5374-86. PMID 22952347 DOI: 10.1158/1078-0432.CCR-12-0736  1
2012 Gurney A, Axelrod F, Bond CJ, Cain J, Chartier C, Donigan L, Fischer M, Chaudhari A, Ji M, Kapoun AM, Lam A, Lazetic S, Ma S, Mitra S, Park IK, ... ... Hoey T, et al. Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors. Proceedings of the National Academy of Sciences of the United States of America. 109: 11717-22. PMID 22753465 DOI: 10.1073/pnas.1120068109  1
2011 Gurney A, Hoey T. Anti-DLL4, a cancer therapeutic with multiple mechanisms of action. Vascular Cell. 3: 18. PMID 21831306 DOI: 10.1186/2045-824X-3-18  1
2011 Fischer M, Yen WC, Kapoun AM, Wang M, O'Young G, Lewicki J, Gurney A, Hoey T. Anti-DLL4 inhibits growth and reduces tumor-initiating cell frequency in colorectal tumors with oncogenic KRAS mutations. Cancer Research. 71: 1520-5. PMID 21193546 DOI: 10.1158/0008-5472.CAN-10-2817  1
2010 Hoey T. Drug resistance, epigenetics, and tumor cell heterogeneity. Science Translational Medicine. 2: 28ps19. PMID 20410528 DOI: 10.1126/scitranslmed.3001056  1
2009 Hoey T, Yen WC, Axelrod F, Basi J, Donigian L, Dylla S, Fitch-Bruhns M, Lazetic S, Park IK, Sato A, Satyal S, Wang X, Clarke MF, Lewicki J, Gurney A. DLL4 blockade inhibits tumor growth and reduces tumor-initiating cell frequency. Cell Stem Cell. 5: 168-77. PMID 19664991 DOI: 10.1016/j.stem.2009.05.019  1
2008 Dylla SJ, Beviglia L, Park IK, Chartier C, Raval J, Ngan L, Pickell K, Aguilar J, Lazetic S, Smith-Berdan S, Clarke MF, Hoey T, Lewicki J, Gurney AL. Colorectal cancer stem cells are enriched in xenogeneic tumors following chemotherapy. Plos One. 3: e2428. PMID 18560594 DOI: 10.1371/journal.pone.0002428  1
2007 Dalerba P, Dylla SJ, Park IK, Liu R, Wang X, Cho RW, Hoey T, Gurney A, Huang EH, Simeone DM, Shelton AA, Parmiani G, Castelli C, Clarke MF. Phenotypic characterization of human colorectal cancer stem cells. Proceedings of the National Academy of Sciences of the United States of America. 104: 10158-63. PMID 17548814 DOI: 10.1073/pnas.0703478104  1
2007 Liu R, Wang X, Chen GY, Dalerba P, Gurney A, Hoey T, Sherlock G, Lewicki J, Shedden K, Clarke MF. The prognostic role of a gene signature from tumorigenic breast-cancer cells. The New England Journal of Medicine. 356: 217-26. PMID 17229949 DOI: 10.1056/NEJMoa063994  1
2005 van der Horst EH, Degenhardt YY, Strelow A, Slavin A, Chinn L, Orf J, Rong M, Li S, See LH, Nguyen KQ, Hoey T, Wesche H, Powers S. Metastatic properties and genomic amplification of the tyrosine kinase gene ACK1. Proceedings of the National Academy of Sciences of the United States of America. 102: 15901-6. PMID 16247015 DOI: 10.1073/pnas.0508014102  1
2005 Herter S, Piper DE, Aaron W, Gabriele T, Cutler G, Cao P, Bhatt AS, Choe Y, Craik CS, Walker N, Meininger D, Hoey T, Austin RJ. Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers. The Biochemical Journal. 390: 125-36. PMID 15839837 DOI: 10.1042/BJ20041955  1
2005 Yang M, Zhong WW, Srivastava N, Slavin A, Yang J, Hoey T, An S. G protein-coupled lysophosphatidic acid receptors stimulate proliferation of colon cancer cells through the {beta}-catenin pathway. Proceedings of the National Academy of Sciences of the United States of America. 102: 6027-32. PMID 15837931 DOI: 10.1073/pnas.0501535102  1
2005 Liu JJ, Cutler G, Li W, Pan Z, Peng S, Hoey T, Chen L, Ling XB. Multiclass cancer classification and biomarker discovery using GA-based algorithms. Bioinformatics (Oxford, England). 21: 2691-7. PMID 15814557 DOI: 10.1093/bioinformatics/bti419  1
2004 Harrison M, Li J, Degenhardt Y, Hoey T, Powers S. Wip1-deficient mice are resistant to common cancer genes. Trends in Molecular Medicine. 10: 359-61. PMID 15310454 DOI: 10.1016/j.molmed.2004.06.010  1
2004 Sasaki Y, Ihara K, Matsuura N, Kohno H, Nagafuchi S, Kuromaru R, Kusuhara K, Takeya R, Hoey T, Sumimoto H, Hara T. Identification of a novel type 1 diabetes susceptibility gene, T-bet. Human Genetics. 115: 177-84. PMID 15241679 DOI: 10.1007/s00439-004-1146-2  1
2004 Sin WC, Zhang Y, Zhong W, Adhikarakunnathu S, Powers S, Hoey T, An S, Yang J. G protein-coupled receptors GPR4 and TDAG8 are oncogenic and overexpressed in human cancers. Oncogene. 23: 6299-303. PMID 15221007 DOI: 10.1038/sj.onc.1207838  1
2003 Li S, Cutler G, Liu JJ, Hoey T, Chen L, Schultz PG, Liao J, Ling XB. A comparative analysis of HGSC and Celera human genome assemblies and gene sets. Bioinformatics (Oxford, England). 19: 1597-605. PMID 12967954 DOI: 10.1093/bioinformatics/btg219  1
2003 Hoey T, Zhang S, Schmidt N, Yu Q, Ramchandani S, Xu X, Naeger LK, Sun YL, Kaplan MH. Distinct requirements for the naturally occurring splice forms Stat4alpha and Stat4beta in IL-12 responses. The Embo Journal. 22: 4237-48. PMID 12912921 DOI: 10.1093/emboj/cdg393  1
2003 Chang HC, Zhang S, Oldham I, Naeger L, Hoey T, Kaplan MH. STAT4 requires the N-terminal domain for efficient phosphorylation. The Journal of Biological Chemistry. 278: 32471-7. PMID 12805384 DOI: 10.1074/jbc.M302776200  1
2003 Pei L, Wiser O, Slavin A, Mu D, Powers S, Jan LY, Hoey T. Oncogenic potential of TASK3 (Kcnk9) depends on K+ channel function. Proceedings of the National Academy of Sciences of the United States of America. 100: 7803-7. PMID 12782791 DOI: 10.1073/pnas.1232448100  1
2003 Mu D, Chen L, Zhang X, See LH, Koch CM, Yen C, Tong JJ, Spiegel L, Nguyen KC, Servoss A, Peng Y, Pei L, Marks JR, Lowe S, Hoey T, et al. Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene. Cancer Cell. 3: 297-302. PMID 12676587 DOI: 10.1016/S1535-6108(03)00054-0  1
2002 Pei L, Peng Y, Yang Y, Ling XB, Van Eyndhoven WG, Nguyen KC, Rubin M, Hoey T, Powers S, Li J. PRC17, a novel oncogene encoding a Rab GTPase-activating protein, is amplified in prostate cancer. Cancer Research. 62: 5420-4. PMID 12359748  1
2002 Li S, Liao J, Cutler G, Hoey T, Hogenesch JB, Cooke MP, Schultz PG, Ling XB. Comparative analysis of human genome assemblies reveals genome-level differences. Genomics. 80: 138-9. PMID 12160725 DOI: 10.1006/geno.2002.6824  1
2002 Broxmeyer HE, Bruns HA, Zhang S, Cooper S, Hangoc G, McKenzie AN, Dent AL, Schindler U, Naeger LK, Hoey T, Kaplan MH. Th1 cells regulate hematopoietic progenitor cell homeostasis by production of oncostatin M. Immunity. 16: 815-25. PMID 12121663 DOI: 10.1016/S1074-7613(02)00319-9  1
2002 Li J, Yang Y, Peng Y, Austin RJ, van Eyndhoven WG, Nguyen KC, Gabriele T, McCurrach ME, Marks JR, Hoey T, Lowe SW, Powers S. Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23. Nature Genetics. 31: 133-4. PMID 12021784 DOI: 10.1038/ng888  1
2001 Hoey T. Expression and purification of lacZ and trpE fusion proteins. Current Protocols in Molecular Biology / Edited by Frederick M. Ausubel ... [Et Al.]. Unit16.5. PMID 18265132 DOI: 10.1002/0471142727.mb1605s28  1
2000 Lawless VA, Zhang S, Ozes ON, Bruns HA, Oldham I, Hoey T, Grusby MJ, Kaplan MH. Stat4 regulates multiple components of IFN-gamma-inducing signaling pathways. Journal of Immunology (Baltimore, Md. : 1950). 165: 6803-8. PMID 11120802  1
1999 Hoey T, Grusby MJ. STATs as mediators of cytokine-induced responses. Advances in Immunology. 71: 145-62. PMID 9917912  1
1999 Naeger LK, McKinney J, Salvekar A, Hoey T. Identification of a STAT4 binding site in the interleukin-12 receptor required for signaling. The Journal of Biological Chemistry. 274: 1875-8. PMID 9890938 DOI: 10.1074/jbc.274.4.1875  1
1998 Sweetser MT, Hoey T, Sun YL, Weaver WM, Price GA, Wilson CB. The roles of nuclear factor of activated T cells and ying-yang 1 in activation-induced expression of the interferon-gamma promoter in T cells. The Journal of Biological Chemistry. 273: 34775-83. PMID 9857002 DOI: 10.1074/jbc.273.52.34775  1
1998 Hoey T, Schindler U. STAT structure and function in signaling. Current Opinion in Genetics & Development. 8: 582-7. PMID 9794817 DOI: 10.1016/S0959-437X(98)80015-4  1
1998 Oukka M, Ho IC, de la Brousse FC, Hoey T, Grusby MJ, Glimcher LH. The transcription factor NFAT4 is involved in the generation and survival of T cells. Immunity. 9: 295-304. PMID 9768749 DOI: 10.1016/S1074-7613(00)80612-3  1
1998 Ranger AM, Grusby MJ, Hodge MR, Gravallese EM, de la Brousse FC, Hoey T, Mickanin C, Baldwin HS, Glimcher LH. The transcription factor NF-ATc is essential for cardiac valve formation. Nature. 392: 186-90. PMID 9515964 DOI: 10.1038/32426  1
1998 Ranger AM, Hodge MR, Gravallese EM, Oukka M, Davidson L, Alt FW, de la Brousse FC, Hoey T, Grusby M, Glimcher LH. Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc. Immunity. 8: 125-34. PMID 9462518 DOI: 10.1016/S1074-7613(00)80465-3  1
1997 Hoey T. A new player in cell death. Science (New York, N.Y.). 278: 1578-9. PMID 9411781 DOI: 10.1126/science.278.5343.1578  1
1996 Schindler U, Hoey T, McKnight SL. Differentiation of T-helper lymphocytes: selective regulation by members of the STAT family of transcription factors. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 1: 507-15. PMID 9078381  1
1996 Kaplan MH, Sun YL, Hoey T, Grusby MJ. Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature. 382: 174-7. PMID 8700209 DOI: 10.1038/382174a0  1
1996 Xu X, Sun YL, Hoey T. Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domain. Science (New York, N.Y.). 273: 794-7. PMID 8670419  1
1996 Hodge MR, Ranger AM, Charles de la Brousse F, Hoey T, Grusby MJ, Glimcher LH. Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice. Immunity. 4: 397-405. PMID 8612134 DOI: 10.1016/S1074-7613(00)80253-8  1
1995 Rooney JW, Hoey T, Glimcher LH. Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 gene. Immunity. 2: 473-83. PMID 7749982 DOI: 10.1016/1074-7613(95)90028-4  1
1995 Hoey T, Sun YL, Williamson K, Xu X. Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins. Immunity. 2: 461-72. PMID 7749981 DOI: 10.1016/1074-7613(95)90027-6  1
1995 Rooney JW, Sun YL, Glimcher LH, Hoey T. Novel NFAT sites that mediate activation of the interleukin-2 promoter in response to T-cell receptor stimulation. Molecular and Cellular Biology. 15: 6299-310. PMID 7565783  1
1993 Crowley TE, Hoey T, Liu JK, Jan YN, Jan LY, Tjian R. A new factor related to TATA-binding protein has highly restricted expression patterns in Drosophila. Nature. 361: 557-61. PMID 8429912 DOI: 10.1038/361557a0  1
1993 Goodrich JA, Hoey T, Thut CJ, Admon A, Tjian R. Drosophila TAFII40 interacts with both a VP16 activation domain and the basal transcription factor TFIIB. Cell. 75: 519-30. PMID 8221891 DOI: 10.1016/0092-8674(93)90386-5  1
1993 Hoey T, Weinzierl RO, Gill G, Chen JL, Dynlacht BD, Tjian R. Molecular cloning and functional analysis of Drosophila TAF110 reveal properties expected of coactivators. Cell. 72: 247-60. PMID 7678780 DOI: 10.1016/0092-8674(93)90664-C  1
1991 Small S, Kraut R, Hoey T, Warrior R, Levine M. Transcriptional regulation of a pair-rule stripe in Drosophila. Genes & Development. 5: 827-39. PMID 2026328  1
1991 Dynlacht BD, Hoey T, Tjian R. Isolation of coactivators associated with the TATA-binding protein that mediate transcriptional activation. Cell. 66: 563-76. PMID 1907890  1
1991 Jiang J, Hoey T, Levine M. Autoregulation of a segmentation gene in Drosophila: combinatorial interaction of the even-skipped homeo box protein with a distal enhancer element. Genes & Development. 5: 265-77. PMID 1671662  1
1990 Hoey T, Dynlacht BD, Peterson MG, Pugh BF, Tjian R. Isolation and characterization of the Drosophila gene encoding the TATA box binding protein, TFIID. Cell. 61: 1179-86. PMID 2194666 DOI: 10.1016/0092-8674(90)90682-5  1
1989 Harding K, Hoey T, Warrior R, Levine M. Autoregulatory and gap gene response elements of the even-skipped promoter of Drosophila. The Embo Journal. 8: 1205-12. PMID 2743979  1
1989 Stanojevi? D, Hoey T, Levine M. Sequence-specific DNA-binding activities of the gap proteins encoded by hunchback and Krüppel in Drosophila. Nature. 341: 331-5. PMID 2507923 DOI: 10.1038/341331a0  1
1988 Hoey T, Warrior R, Manak J, Levine M. DNA-binding activities of the Drosophila melanogaster even-skipped protein are mediated by its homeo domain and influenced by protein context. Molecular and Cellular Biology. 8: 4598-607. PMID 2905420  1
1988 Levine M, Hoey T. Homeobox proteins as sequence-specific transcription factors. Cell. 55: 537-40. PMID 2902929  1
1988 Chen HZ, Hoey T, Zubay G. Purification and properties of the Drosophila zen protein. Molecular and Cellular Biochemistry. 79: 181-9. PMID 2899836 DOI: 10.1007/BF02424561  1
1988 Hoey T, Levine M. Divergent homeo box proteins recognize similar DNA sequences in Drosophila. Nature. 332: 858-61. PMID 2895896 DOI: 10.1038/332858a0  1
1987 Rushlow C, Doyle H, Hoey T, Levine M. Molecular characterization of the zerknüllt region of the Antennapedia gene complex in Drosophila. Genes & Development. 1: 1268-79. PMID 2892759  1
1987 Frasch M, Hoey T, Rushlow C, Doyle H, Levine M. Characterization and localization of the even-skipped protein of Drosophila. The Embo Journal. 6: 749-59. PMID 2884106  1
1986 Doyle HJ, Harding K, Hoey T, Levine M. Transcripts encoded by a homoeo box gene are restricted to dorsal tissues of Drosophila embryos. Nature. 323: 76-9. PMID 3755802 DOI: 10.1038/323076a0  1
1986 Harding K, Rushlow C, Doyle HJ, Hoey T, Levine M. Cross-regulatory interactions among pair-rule genes in Drosophila. Science (New York, N.Y.). 233: 953-9. PMID 3755551 DOI: 10.1126/science.3755551  1
1986 Hoey T, Doyle HJ, Harding K, Wedeen C, Levine M. Homeo box gene expression in anterior and posterior regions of the Drosophila embryo. Proceedings of the National Academy of Sciences of the United States of America. 83: 4809-13. PMID 3014511  1
1986 Doyle HJ, Harding K, Hoey T, Levine M. Transcripts encoded by a homoeo box gene are resticted to dorsal tissues of Drosophila embryos Nature. 322: 76-79.  1
1985 Levine M, Harding K, Wedeen C, Doyle H, Hoey T, Radomska H. Expression of the homeo box gene family in Drosophila. Cold Spring Harbor Symposia On Quantitative Biology. 50: 209-22. PMID 3868479  1
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