Liam Keegan - Publications

Affiliations: 
Genetics and Molecular Medicine University of Edinburgh, Edinburgh, Scotland, United Kingdom 

39 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 O'Connell MA, Mannion NM, Keegan LP. The Epitranscriptome and Innate Immunity. Plos Genetics. 11: e1005687. PMID 26658668 DOI: 10.1371/journal.pgen.1005687  1
2014 Mannion NM, Greenwood SM, Young R, Cox S, Brindle J, Read D, Nellåker C, Vesely C, Ponting CP, McLaughlin PJ, Jantsch MF, Dorin J, Adams IR, Scadden AD, Ohman M, ... Keegan LP, et al. The RNA-editing enzyme ADAR1 controls innate immune responses to RNA. Cell Reports. 9: 1482-94. PMID 25456137 DOI: 10.1016/j.celrep.2014.10.041  1
2014 McLaughlin PJ, Keegan LP. Conflict RNA modification, host-parasite co-evolution, and the origins of DNA and DNA-binding proteins1. Biochemical Society Transactions. 42: 1159-67. PMID 25110019 DOI: 10.1042/BST20140147  1
2014 Li X, Overton IM, Baines RA, Keegan LP, O'Connell MA. The ADAR RNA editing enzyme controls neuronal excitability in Drosophila melanogaster. Nucleic Acids Research. 42: 1139-51. PMID 24137011 DOI: 10.1093/nar/gkt909  1
2013 Ramaswami G, Zhang R, Piskol R, Keegan LP, Deng P, O'Connell MA, Li JB. Identifying RNA editing sites using RNA sequencing data alone. Nature Methods. 10: 128-32. PMID 23291724 DOI: 10.1038/nmeth.2330  1
2012 Rice GI, Kasher PR, Forte GM, Mannion NM, Greenwood SM, Szynkiewicz M, Dickerson JE, Bhaskar SS, Zampini M, Briggs TA, Jenkinson EM, Bacino CA, Battini R, Bertini E, Brogan PA, ... ... Keegan LP, et al. Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature. Nature Genetics. 44: 1243-8. PMID 23001123 DOI: 10.1038/ng.2414  1
2012 Paro S, Li X, O'Connell MA, Keegan LP. Regulation and functions of ADAR in drosophila. Current Topics in Microbiology and Immunology. 353: 221-36. PMID 21761288 DOI: 10.1007/82_2011_152  1
2012 Catterall S, Del Debbio L, Giedt J, Keegan L. Monte Carlo renormalization group minimal walking technicolor Physical Review D - Particles, Fields, Gravitation and Cosmology. 85. DOI: 10.1103/PhysRevD.85.094501  1
2011 Marcucci R, Brindle J, Paro S, Casadio A, Hempel S, Morrice N, Bisso A, Keegan LP, Del Sal G, O'Connell MA. Pin1 and WWP2 regulate GluR2 Q/R site RNA editing by ADAR2 with opposing effects. The Embo Journal. 30: 4211-22. PMID 21847096 DOI: 10.1038/emboj.2011.303  1
2011 Heale BS, Keegan LP, O'Connell MA. The Effect of RNA Editing and ADARs on miRNA Biogenesis and Function. Advances in Experimental Medicine and Biology. 700: 76-84. PMID 21755475 DOI: 10.1007/978-1-4419-7823-3_8  1
2011 Keegan LP, McGurk L, Palavicini JP, Brindle J, Paro S, Li X, Rosenthal JJ, O'Connell MA. Functional conservation in human and Drosophila of Metazoan ADAR2 involved in RNA editing: loss of ADAR1 in insects. Nucleic Acids Research. 39: 7249-62. PMID 21622951 DOI: 10.1093/nar/gkr423  1
2011 Sun H, Raja A, O'Connell MA, Mann V, Noble B, Keegan LP. Laser microdissection and pressure catapulting of single human motor neurons for RNA editing analysis. Methods in Molecular Biology (Clifton, N.J.). 718: 75-87. PMID 21370042 DOI: 10.1007/978-1-61779-018-8_4  1
2011 Hogg M, Paro S, Keegan LP, O'Connell MA. RNA editing by mammalian ADARs. Advances in Genetics. 73: 87-120. PMID 21310295 DOI: 10.1016/B978-0-12-380860-8.00003-3  1
2011 Bursa F, Del Debbio L, Keegan L, Pica C, Pickup T. Mass anomalous dimension in SU(2) with six fundamental fermions Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics. 696: 374-379. DOI: 10.1016/j.physletb.2010.12.050  1
2010 Galeano F, Leroy A, Rossetti C, Gromova I, Gautier P, Keegan LP, Massimi L, Di Rocco C, O'Connell MA, Gallo A. Human BLCAP transcript: new editing events in normal and cancerous tissues. International Journal of Cancer. Journal International Du Cancer. 127: 127-37. PMID 19908260 DOI: 10.1002/ijc.25022  1
2010 Bursa F, Del Debbio L, Keegan L, Pica C, Pickup T. Mass anomalous dimension in SU(2) with two adjoint fermions Physical Review D - Particles, Fields, Gravitation and Cosmology. 81. DOI: 10.1103/PhysRevD.81.014505  1
2009 Heale BS, Keegan LP, O'Connell MA. ADARs have effects beyond RNA editing. Cell Cycle (Georgetown, Tex.). 8: 4011-2. PMID 19949296  1
2009 Carpenter JA, Keegan LP, Wilfert L, O'Connell MA, Jiggins FM. Evidence for ADAR-induced hypermutation of the Drosophila sigma virus (Rhabdoviridae). Bmc Genetics. 10: 75. PMID 19941656 DOI: 10.1186/1471-2156-10-75  1
2009 Heale BS, Keegan LP, McGurk L, Michlewski G, Brindle J, Stanton CM, Caceres JF, O'Connell MA. Editing independent effects of ADARs on the miRNA/siRNA pathways. The Embo Journal. 28: 3145-56. PMID 19713932 DOI: 10.1038/emboj.2009.244  1
2007 McGurk L, Morrison H, Keegan LP, Sharpe J, O'Connell MA. Three-dimensional imaging of Drosophila melanogaster. Plos One. 2: e834. PMID 17786206 DOI: 10.1371/journal.pone.0000834  1
2007 Keegan LP, Rosenthal JJ, Roberson LM, O'Connell MA. Purification and assay of ADAR activity. Methods in Enzymology. 424: 301-17. PMID 17662847 DOI: 10.1016/S0076-6879(07)24014-5  1
2006 O'Connell MA, Keegan LP. Drosha versus ADAR: wrangling over pri-miRNA. Nature Structural & Molecular Biology. 13: 3-4. PMID 16395313 DOI: 10.1038/nsmb0106-3  1
2005 Desterro JM, Keegan LP, Jaffray E, Hay RT, O'Connell MA, Carmo-Fonseca M. SUMO-1 modification alters ADAR1 editing activity. Molecular Biology of the Cell. 16: 5115-26. PMID 16120648 DOI: 10.1091/mbc.E05-06-0536  1
2005 Keegan LP, Brindle J, Gallo A, Leroy A, Reenan RA, O'Connell MA. Tuning of RNA editing by ADAR is required in Drosophila. The Embo Journal. 24: 2183-93. PMID 15920480 DOI: 10.1038/sj.emboj.7600691  1
2004 Ring GM, O'Connell MA, Keegan LP. Purification and assay of recombinant ADAR proteins expressed in the yeast Pichia pastoris or in Escherichia coli. Methods in Molecular Biology (Clifton, N.J.). 265: 219-38. PMID 15103076 DOI: 10.1385/1-59259-775-0:219  1
2004 Keegan LP, Leroy A, Sproul D, O'Connell MA. Adenosine deaminases acting on RNA (ADARs): RNA-editing enzymes. Genome Biology. 5: 209. PMID 14759252 DOI: 10.1186/gb-2004-5-2-209  1
2003 Gallo A, Keegan LP, Ring GM, O'Connell MA. An ADAR that edits transcripts encoding ion channel subunits functions as a dimer. The Embo Journal. 22: 3421-30. PMID 12840004 DOI: 10.1093/emboj/cdg327  1
2003 Desterro JM, Keegan LP, Lafarga M, Berciano MT, O'Connell M, Carmo-Fonseca M. Dynamic association of RNA-editing enzymes with the nucleolus. Journal of Cell Science. 116: 1805-18. PMID 12665561 DOI: 10.1242/jcs.00371  1
2002 Gallo A, Thomson E, Brindle J, O'Connell MA, Keegan LP. Micro-processing events in mRNAs identified by DHPLC analysis. Nucleic Acids Research. 30: 3945-53. PMID 12235378  1
2002 Bownes M, Charlesworth B, Davis I, Finnegan D, Heck M, Jarman A, Keegan L, Ohkura H, Rabouille C. Report on the 17(th) European Drosophila research conference. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 24: 99-101. PMID 11782955 DOI: 10.1002/bies.10048  1
2001 Keegan LP, Gallo A, O'Connell MA. The many roles of an RNA editor. Nature Reviews. Genetics. 2: 869-78. PMID 11715042 DOI: 10.1038/35098584  1
2000 Keegan LP, Gallo A, O'Connell MA. Development. Survival is impossible without an editor. Science (New York, N.Y.). 290: 1707-9. PMID 11186391 DOI: 10.1126/science.290.5497.1707  1
2000 Palladino MJ, Keegan LP, O'Connell MA, Reenan RA. A-to-I pre-mRNA editing in Drosophila is primarily involved in adult nervous system function and integrity. Cell. 102: 437-49. PMID 10966106  1
2000 Palladino MJ, Keegan LP, O'Connell MA, Reenan RA. dADAR, a Drosophila double-stranded RNA-specific adenosine deaminase is highly developmentally regulated and is itself a target for RNA editing. Rna (New York, N.Y.). 6: 1004-18. PMID 10917596 DOI: 10.1017/S1355838200000248  1
2000 Keegan LP, Gerber AP, Brindle J, Leemans R, Gallo A, Keller W, O'Connell MA. The properties of a tRNA-specific adenosine deaminase from Drosophila melanogaster support an evolutionary link between pre-mRNA editing and tRNA modification. Molecular and Cellular Biology. 20: 825-33. PMID 10629039 DOI: 10.1128/MCB.20.3.825-833.2000  1
1998 O'Connell MA, Gerber A, Keegan LP. Purification of native and recombinant double-stranded RNA-specific adenosine deaminases. Methods (San Diego, Calif.). 15: 51-62. PMID 9614652 DOI: 10.1006/meth.1998.0605  1
1997 Keegan LP, Haerry TE, Crotty DA, Packer AI, Wolgemuth DJ, Gehring WJ. A sequence conserved in vertebrate Hox gene introns functions as an enhancer regulated by posterior homeotic genes in Drosophila imaginal discs. Mechanisms of Development. 63: 145-57. PMID 9203138 DOI: 10.1016/S0925-4773(97)00038-5  1
1986 Keegan L, Gill G, Ptashne M. Separation of DNA binding from the transcription-activating function of a eukaryotic regulatory protein. Science (New York, N.Y.). 231: 699-704. PMID 3080805  1
1984 Silver PA, Keegan LP, Ptashne M. Amino terminus of the yeast GAL4 gene product is sufficient for nuclear localization. Proceedings of the National Academy of Sciences of the United States of America. 81: 5951-5. PMID 6091123  1
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