Melanie Cobb - Publications

Affiliations: 
Pharmacology University of Texas Southwestern Medical Center, Dallas, TX, United States 
Website:
http://www.utsouthwestern.edu/fis/faculty/11375/melanie-cobb.html

140 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Kalwat MA, Huang Z, Binns DD, McGlynn K, Cobb MH. α-Adrenergic Disruption of β Cell BDNF-TrkB Receptor Tyrosine Kinase Signaling. Frontiers in Cell and Developmental Biology. 8: 576396. PMID 33178692 DOI: 10.3389/fcell.2020.576396  0.84
2020 Dyachok J, Earnest S, Iturraran EN, Cobb MH, Ross EM. Correction: Amino acids regulate mTORC1 by an obligate two-step mechanism. The Journal of Biological Chemistry. 295: 8868. PMID 32591444 DOI: 10.1074/jbc.AAC120.014360  0.52
2019 Shen C, Li B, Astudillo L, Deutscher MP, Cobb MH, Capobianco AJ, Lee E, Robbins DJ. The CK1α Activator Pyrvinium Enhances the Catalytic Efficiency (/) of CK1α. Biochemistry. PMID 31820934 DOI: 10.1021/acs.biochem.9b00891  0.88
2019 Wang XD, Hu R, Ding Q, Savage TK, Huffman KE, Williams N, Cobb MH, Minna JD, Johnson JE, Yu Y. Subtype-specific secretomic characterization of pulmonary neuroendocrine tumor cells. Nature Communications. 10: 3201. PMID 31324758 DOI: 10.1038/s41467-019-11153-5  0.52
2019 Taylor CA, Cormier KW, Keenan SE, Earnest S, Stippec S, Wichaidit C, Juang YC, Wang J, Shvartsman SY, Goldsmith EJ, Cobb MH. Functional divergence caused by mutations in an energetic hotspot in ERK2. Proceedings of the National Academy of Sciences of the United States of America. PMID 31296562 DOI: 10.1073/pnas.1905015116  0.8
2018 Gallolu Kankanamalage S, Karra AS, Cobb MH. WNK pathways in cancer signaling networks. Cell Communication and Signaling : Ccs. 16: 72. PMID 30390653 DOI: 10.1186/s12964-018-0287-1  1
2018 Kalwat MA, Hwang IH, Macho J, Grzemska MG, Yang JZ, McGlynn K, MacMillan JB, Cobb MH. Chromomycin A potently inhibits glucose-stimulated insulin secretion from pancreatic β cells. The Journal of General Physiology. PMID 30352794 DOI: 10.1085/jgp.201812177  0.84
2018 Jaykumar AB, Karra AS, Cobb MH. Pulling a MAST1 on Cisplatin Resistance. Cancer Cell. 34: 183-185. PMID 30107173 DOI: 10.1016/j.ccell.2018.07.010  1
2018 Taylor CA, An SW, Kankanamalage SG, Stippec S, Earnest S, Trivedi AT, Yang JZ, Mirzaei H, Huang CL, Cobb MH. OSR1 regulates a subset of inward rectifier potassium channels via a binding motif variant. Proceedings of the National Academy of Sciences of the United States of America. PMID 29581290 DOI: 10.1073/pnas.1802339115  0.8
2018 Thorne CA, Chen IW, Sanman LE, Cobb MH, Wu LF, Altschuler SJ. Enteroid Monolayers Reveal an Autonomous WNT and BMP Circuit Controlling Intestinal Epithelial Growth and Organization. Developmental Cell. PMID 29503158 DOI: 10.1016/j.devcel.2018.01.024  0.8
2018 He M, Liu S, Gallolu Kankanamalage S, Borromeo MD, Girard L, Gazdar AF, Minna JD, Johnson JE, Cobb MH. The Epithelial Sodium Channel (αENaC) Is a Downstream Therapeutic Target of ASCL1 in Pulmonary Neuroendocrine Tumors. Translational Oncology. 11: 292-299. PMID 29413762 DOI: 10.1016/j.tranon.2018.01.004  1
2017 Kalwat MA, Wichaidit C, Nava Garcia AY, McCoy MK, McGlynn K, Hwang IH, MacMillan JB, Posner BA, Cobb MH. Correction to Insulin Promoter-Driven Gaussia Luciferase-Based Insulin Secretion Biosensor Assay for Discovery of β-Cell Glucose-Sensing Pathways. Acs Sensors. 2: 316. PMID 28723136 DOI: 10.1021/acssensors.7b00012  0.84
2017 Li B, Orton D, Neitzel LR, Astudillo L, Shen C, Long J, Chen X, Kirkbride KC, Doundoulakis T, Guerra ML, Zaias J, Fei DL, Rodriguez-Blanco J, Thorne C, Wang Z, ... ... Cobb MH, et al. Differential abundance of CK1α provides selectivity for pharmacological CK1α activators to target WNT-dependent tumors. Science Signaling. 10. PMID 28655862 DOI: 10.1126/scisignal.aak9916  0.88
2017 Karra AS, Stippec S, Cobb MH. Assaying Protein Kinase Activity with Radiolabeled ATP. Journal of Visualized Experiments : Jove. PMID 28605363 DOI: 10.3791/55504  1
2017 Kalwat MA, Cobb M. Mechanisms of the Amplifying Pathway of Insulin Secretion in the β Cell. Pharmacology & Therapeutics. PMID 28527919 DOI: 10.1016/j.pharmthera.2017.05.003  0.84
2017 Gallolu Kankanamalage S, Lee AY, Wichaidit C, Lorente-Rodriguez A, Shah AM, Stippec S, Whitehurst AW, Cobb MH. WNK1 is an unexpected autophagy inhibitor. Autophagy. 1-2. PMID 28282258 DOI: 10.1080/15548627.2017.1286431  1
2017 Guerra ML, Kalwat MA, McGlynn K, Cobb MH. Sucralose activates an ERK1/2-ribosomal protein S6 signaling axis. Febs Open Bio. 7: 174-186. PMID 28174684 DOI: 10.1002/2211-5463.12172  0.84
2016 Gallolu Kankanamalage S, Lee AY, Wichaidit C, Lorente-Rodriguez A, Shah AM, Stippec S, Whitehurst AW, Cobb MH. Multistep regulation of autophagy by WNK1. Proceedings of the National Academy of Sciences of the United States of America. PMID 27911840 DOI: 10.1073/pnas.1617649113  1
2016 Kalwat MA, Wichaidit C, Nava Garcia AY, McCoy MK, McGlynn K, Hwang IH, MacMillan JB, Posner BA, Cobb MH. Insulin promoter-driven Gaussia luciferase-based insulin secretion biosensor assay for discovery of β-cell glucose-sensing pathways. Acs Sensors. 1: 1208-1212. PMID 27819058 DOI: 10.1021/acssensors.6b00433  0.84
2016 Dyachok J, Earnest S, Iturraran EN, Cobb MH, Ross EM. Amino Acids Regulate mTORC1 by an Obligate Two-Step Mechanism. The Journal of Biological Chemistry. PMID 27587390 DOI: 10.1074/jbc.M116.732511  0.52
2016 Barry DM, Koo YS, Norden PR, Wylie LA, Xu K, Wichaidit C, Azizoglu DB, Zheng Y, Cobb MH, Davis G, Cleaver O. Rasip1-Mediated Rho GTPase Signaling Regulates Blood Vessel Tubulogenesis via Non-Muscle Myosin II. Circulation Research. PMID 27486147 DOI: 10.1161/CIRCRESAHA.116.309094  0.6
2016 Borromeo MD, Savage TK, Kollipara RK, He M, Augustyn A, Osborne JK, Girard L, Minna JD, Gazdar AF, Cobb MH, Johnson JE. ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs. Cell Reports. PMID 27452466 DOI: 10.1016/j.celrep.2016.06.081  0.56
2016 Dbouk HA, Huang CL, Cobb MH. Hypertension: The Missing WNKs. American Journal of Physiology. Renal Physiology. ajprenal.00358.2015. PMID 27009339 DOI: 10.1152/ajprenal.00358.2015  1
2016 McReynolds AC, Karra AS, Li Y, Lopez ED, Turjanski AG, Dioum E, Lorenz K, Zaganjor E, Stippec S, McGlynn K, Earnest S, Cobb MH. Phosphorylation or mutation of the ERK2 activation loop alters oligonucleotide binding. Biochemistry. PMID 26950759 DOI: 10.1021/acs.biochem.6b00096  1
2016 Bunn PA, Minna J, Augustyn A, Gazdar A, Ouadah Y, Krasnow MA, Berns A, Brambilla E, Rekhtman N, Massion PP, Niederst M, Peifer M, Yokota J, Govindan R, Poirier J, ... ... Cobb MH, et al. Small Cell Lung Cancer: Can recent advances in biology and molecular biology be translated into improved outcomes? Journal of Thoracic Oncology : Official Publication of the International Association For the Study of Lung Cancer. PMID 26829312 DOI: 10.1016/j.jtho.2016.01.012  1
2016 Kalwat MA, Huang Z, Wichaidit C, McGlynn K, Earnest S, Savoia C, Dioum EM, Schneider JW, Hutchison MR, Cobb MH. Isoxazole alters metabolites and gene expression, decreasing proliferation and promoting a neuroendocrine phenotype in β-cells. Acs Chemical Biology. PMID 26828310 DOI: 10.1021/acschembio.5b00993  1
2015 Karra AS, Taylor CA, Thorne CA, Cobb MH. A Kinase Divided. Cancer Cell. 28: 145-7. PMID 26267529 DOI: 10.1016/j.ccell.2015.07.008  1
2015 Taylor CA, Juang YC, Earnest S, Sengupta S, Goldsmith EJ, Cobb MH. Domain-Swapping Switch Point in Ste20 Protein Kinase SPAK. Biochemistry. PMID 26208601 DOI: 10.1021/acs.biochem.5b00593  1
2015 Wauson EM, Guerra ML, Dyachok J, McGlynn K, Giles J, Ross EM, Cobb MH. Differential Regulation of ERK1/2 and mTORC1 Through T1R1/T1R3 in MIN6 Cells. Molecular Endocrinology (Baltimore, Md.). 29: 1114-22. PMID 26168033 DOI: 10.1210/ME.2014-1181  1
2014 Dbouk HA, Weil LM, Perera GK, Dellinger MT, Pearson G, Brekken RA, Cobb MH. Actions of the protein kinase WNK1 on endothelial cells are differentially mediated by its substrate kinases OSR1 and SPAK. Proceedings of the National Academy of Sciences of the United States of America. 111: 15999-6004. PMID 25362046 DOI: 10.1073/pnas.1419057111  1
2014 Augustyn A, Borromeo M, Wang T, Fujimoto J, Shao C, Dospoy PD, Lee V, Tan C, Sullivan JP, Larsen JE, Girard L, Behrens C, Wistuba II, Xie Y, Cobb MH, et al. ASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers. Proceedings of the National Academy of Sciences of the United States of America. 111: 14788-93. PMID 25267614 DOI: 10.1073/pnas.1410419111  1
2014 Chamberlain CE, Scheel DW, McGlynn K, Kim H, Miyatsuka T, Wang J, Nguyen V, Zhao S, Mavropoulos A, Abraham AG, O'Neill E, Ku GM, Cobb MH, Martin GR, German MS. Menin determines K-RAS proliferative outputs in endocrine cells. The Journal of Clinical Investigation. 124: 4093-101. PMID 25133424 DOI: 10.1172/JCI69004  1
2014 Klein AM, Cobb MH. ERK5 signaling gets XIAPed: a role for ubiquitin in the disassembly of a MAPK cascade. The Embo Journal. 33: 1735-6. PMID 25012518 DOI: 10.15252/embj.201489205  1
2014 Zaganjor E, Weil LM, Gonzales JX, Minna JD, Cobb MH. Ras transformation uncouples the kinesin-coordinated cellular nutrient response. Proceedings of the National Academy of Sciences of the United States of America. 111: 10568-73. PMID 25002494 DOI: 10.1073/pnas.1411016111  1
2014 Piala AT, Moon TM, Akella R, He H, Cobb MH, Goldsmith EJ. Chloride sensing by WNK1 involves inhibition of autophosphorylation. Science Signaling. 7: ra41. PMID 24803536 DOI: 10.1126/scisignal.2005050  1
2014 Wauson EM, Dbouk HA, Ghosh AB, Cobb MH. G protein-coupled receptors and the regulation of autophagy. Trends in Endocrinology and Metabolism: Tem. 25: 274-82. PMID 24751357 DOI: 10.1016/j.tem.2014.03.006  1
2014 Osborne JK, Guerra ML, Gonzales JX, McMillan EA, Minna JD, Cobb MH. NeuroD1 mediates nicotine-induced migration and invasion via regulation of the nicotinic acetylcholine receptor subunits in a subset of neural and neuroendocrine carcinomas. Molecular Biology of the Cell. 25: 1782-92. PMID 24719457 DOI: 10.1091/mbc.E13-06-0316  1
2014 Guerra ML, Wauson EM, McGlynn K, Cobb MH. Muscarinic control of MIN6 pancreatic β cells is enhanced by impaired amino acid signaling. The Journal of Biological Chemistry. 289: 14370-9. PMID 24695728 DOI: 10.1074/jbc.M114.565069  1
2014 Zaganjor E, Osborne JK, Weil LM, Diaz-Martinez LA, Gonzales JX, Singel SM, Larsen JE, Girard L, Minna JD, Cobb MH. Ras regulates kinesin 13 family members to control cell migration pathways in transformed human bronchial epithelial cells. Oncogene. 33: 5457-66. PMID 24240690 DOI: 10.1038/onc.2013.486  1
2014 Augustyn A, Borromeo M, Wang T, Fujimoto J, Shao C, Dospoy PD, Lee V, Tan C, Sullivan JP, Larsen JE, Girard L, Behrens C, Wistuba II, Xie Y, Cobb MH, et al. ASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers Proceedings of the National Academy of Sciences of the United States of America. 111: 14788-14793. DOI: 10.1073/pnas.1410419111/-/DCSupplemental  1
2013 Sengupta S, Lorente-Rodríguez A, Earnest S, Stippec S, Guo X, Trudgian DC, Mirzaei H, Cobb MH. Regulation of OSR1 and the sodium, potassium, two chloride cotransporter by convergent signals. Proceedings of the National Academy of Sciences of the United States of America. 110: 18826-31. PMID 24191005 DOI: 10.1073/pnas.1318676110  1
2013 Osborne JK, Larsen JE, Gonzales JX, Shames DS, Sato M, Wistuba II, Girard L, Minna JD, Cobb MH. NeuroD1 regulation of migration accompanies the differential sensitivity of neuroendocrine carcinomas to TrkB inhibition. Oncogenesis. 2: e63. PMID 23958853 DOI: 10.1038/oncsis.2013.24  1
2013 Wauson EM, Guerra ML, Barylko B, Albanesi JP, Cobb MH. Off-target effects of MEK inhibitors. Biochemistry. 52: 5164-6. PMID 23848362 DOI: 10.1021/bi4007644  1
2013 Wauson EM, Lorente-Rodríguez A, Cobb MH. Minireview: Nutrient sensing by G protein-coupled receptors. Molecular Endocrinology (Baltimore, Md.). 27: 1188-97. PMID 23820899 DOI: 10.1210/me.2013-1100  1
2013 Osborne JK, Larsen JE, Shields MD, Gonzales JX, Shames DS, Sato M, Kulkarni A, Wistuba II, Girard L, Minna JD, Cobb MH. NeuroD1 regulates survival and migration of neuroendocrine lung carcinomas via signaling molecules TrkB and NCAM. Proceedings of the National Academy of Sciences of the United States of America. 110: 6524-9. PMID 23553831 DOI: 10.1073/pnas.1303932110  1
2013 Klein AM, Zaganjor E, Cobb MH. Chromatin-tethered MAPKs. Current Opinion in Cell Biology. 25: 272-7. PMID 23434067 DOI: 10.1016/j.ceb.2013.01.002  1
2013 Wauson EM, Zaganjor E, Cobb MH. Amino acid regulation of autophagy through the GPCR TAS1R1-TAS1R3. Autophagy. 9: 418-9. PMID 23222068 DOI: 10.4161/auto.22911  1
2012 Lee AY, Chen W, Stippec S, Self J, Yang F, Ding X, Chen S, Juang YC, Cobb MH. Protein kinase WNK3 regulates the neuronal splicing factor Fox-1. Proceedings of the National Academy of Sciences of the United States of America. 109: 16841-6. PMID 23027929 DOI: 10.1073/pnas.1215406109  1
2012 Sengupta S, Tu SW, Wedin K, Earnest S, Stippec S, Luby-Phelps K, Cobb MH. Interactions with WNK (with no lysine) family members regulate oxidative stress response 1 and ion co-transporter activity. The Journal of Biological Chemistry. 287: 37868-79. PMID 22989884 DOI: 10.1074/jbc.M112.398750  1
2012 Wauson EM, Zaganjor E, Lee AY, Guerra ML, Ghosh AB, Bookout AL, Chambers CP, Jivan A, McGlynn K, Hutchison MR, Deberardinis RJ, Cobb MH. The G protein-coupled taste receptor T1R1/T1R3 regulates mTORC1 and autophagy. Molecular Cell. 47: 851-62. PMID 22959271 DOI: 10.1016/j.molcel.2012.08.001  1
2012 Osborne JK, Zaganjor E, Cobb MH. Signal control through Raf: in sickness and in health. Cell Research. 22: 14-22. PMID 22143568 DOI: 10.1038/cr.2011.193  1
2012 Walter JD, Hunter M, Cobb M, Traeger G, Spiegel PC. Thiostrepton inhibits stable 70S ribosome binding and ribosome-dependent GTPase activation of elongation factor G and elongation factor 4. Nucleic Acids Research. 40: 360-70. PMID 21908407 DOI: 10.1093/nar/gkr623  1
2011 Dioum EM, Osborne JK, Goetsch S, Russell J, Schneider JW, Cobb MH. A small molecule differentiation inducer increases insulin production by pancreatic β cells. Proceedings of the National Academy of Sciences of the United States of America. 108: 20713-8. PMID 22143803 DOI: 10.1073/pnas.1118526109  1
2011 Tu SW, Bugde A, Luby-Phelps K, Cobb MH. WNK1 is required for mitosis and abscission. Proceedings of the National Academy of Sciences of the United States of America. 108: 1385-90. PMID 21220314 DOI: 10.1073/pnas.1018567108  1
2010 Klein AM, Dioum EM, Cobb MH. Exposing contingency plans for kinase networks. Cell. 143: 867-9. PMID 21145453 DOI: 10.1016/j.cell.2010.11.046  1
2010 Duan L, Cobb MH. Calcineurin increases glucose activation of ERK1/2 by reversing negative feedback. Proceedings of the National Academy of Sciences of the United States of America. 107: 22314-9. PMID 21135229 DOI: 10.1073/pnas.1016630108  1
2010 Jivan A, Ranganathan A, Cobb MH. Reconstitution of the nuclear transport of the MAP kinase ERK2. Methods in Molecular Biology (Clifton, N.J.). 661: 273-85. PMID 20811989 DOI: 10.1007/978-1-60761-795-2_16  1
2010 Heise CJ, Xu BE, Deaton SL, Cha SK, Cheng CJ, Earnest S, Sengupta S, Juang YC, Stippec S, Xu Y, Zhao Y, Huang CL, Cobb MH. Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members. The Journal of Biological Chemistry. 285: 25161-7. PMID 20525693 DOI: 10.1074/jbc.M110.103432  0.76
2010 Shao C, Lawrence MC, Cobb MH. Regulation of CCAAT/enhancer-binding protein homologous protein (CHOP) expression by interleukin-1 beta in pancreatic beta cells. The Journal of Biological Chemistry. 285: 19710-9. PMID 20424162 DOI: 10.1074/jbc.M109.087486  1
2009 Lawrence MC, Shao C, McGlynn K, Naziruddin B, Levy MF, Cobb MH. Multiple chromatin-bound protein kinases assemble factors that regulate insulin gene transcription. Proceedings of the National Academy of Sciences of the United States of America. 106: 22181-6. PMID 20018749 DOI: 10.1073/pnas.0912596106  1
2009 Deaton SL, Sengupta S, Cobb MH. WNK kinases and blood pressure control. Current Hypertension Reports. 11: 421-6. PMID 19895753 DOI: 10.1007/s11906-009-0072-z  1
2009 Dioum EM, Wauson EM, Cobb MH. MAP-ping unconventional protein-DNA interactions. Cell. 139: 462-3. PMID 19879834 DOI: 10.1016/j.cell.2009.10.007  1
2009 Jivan A, Earnest S, Juang YC, Cobb MH. Radial spoke protein 3 is a mammalian protein kinase A-anchoring protein that binds ERK1/2. The Journal of Biological Chemistry. 284: 29437-45. PMID 19684019 DOI: 10.1074/jbc.M109.048181  1
2009 Zheng Y, Xia Y, Hawke D, Halle M, Tremblay ML, Gao X, Zhou XZ, Aldape K, Cobb MH, Xie K, He J, Lu Z. FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST. Molecular Cell. 35: 11-25. PMID 19595712 DOI: 10.1016/j.molcel.2009.06.013  0.44
2009 Lee SJ, Cobb MH, Goldsmith EJ. Crystal structure of domain-swapped STE20 OSR1 kinase domain. Protein Science : a Publication of the Protein Society. 18: 304-13. PMID 19177573 DOI: 10.1002/pro.27  1
2009 Min X, Akella R, He H, Humphreys JM, Tsutakawa SE, Lee SJ, Tainer JA, Cobb MH, Goldsmith EJ. The structure of the MAP2K MEK6 reveals an autoinhibitory dimer. Structure (London, England : 1993). 17: 96-104. PMID 19141286 DOI: 10.1016/j.str.2008.11.007  1
2009 Chen Y, Chen W, Cobb MH, Zhao Y. PTMap--a sequence alignment software for unrestricted, accurate, and full-spectrum identification of post-translational modification sites. Proceedings of the National Academy of Sciences of the United States of America. 106: 761-6. PMID 19136633 DOI: 10.1073/pnas.0811739106  1
2009 Chen W, Chen Y, Xu BE, Juang YC, Stippec S, Zhao Y, Cobb MH. Regulation of a third conserved phosphorylation site in SGK1. The Journal of Biological Chemistry. 284: 3453-60. PMID 19068477 DOI: 10.1074/jbc.M807502200  1
2009 Shao C, Cobb MH. Sumoylation regulates the transcriptional activity of MafA in pancreatic beta cells. The Journal of Biological Chemistry. 284: 3117-24. PMID 19029092 DOI: 10.1074/jbc.M806286200  1
2008 Lawrence MC, McGlynn K, Shao C, Duan L, Naziruddin B, Levy MF, Cobb MH. Chromatin-bound mitogen-activated protein kinases transmit dynamic signals in transcription complexes in beta-cells. Proceedings of the National Academy of Sciences of the United States of America. 105: 13315-20. PMID 18755896 DOI: 10.1073/pnas.0806465105  1
2008 Lawrence MC, Jivan A, Shao C, Duan L, Goad D, Zaganjor E, Osborne J, McGlynn K, Stippec S, Earnest S, Chen W, Cobb MH. The roles of MAPKs in disease. Cell Research. 18: 436-42. PMID 18347614 DOI: 10.1038/cr.2008.37  1
2007 Huang CL, Cha SK, Wang HR, Xie J, Cobb MH. WNKs: protein kinases with a unique kinase domain. Experimental & Molecular Medicine. 39: 565-73. PMID 18059132 DOI: 10.1038/emm.2007.62  1
2007 Oh E, Heise CJ, English JM, Cobb MH, Thurmond DC. WNK1 is a novel regulator of Munc18c-syntaxin 4 complex formation in soluble NSF attachment protein receptor (SNARE)-mediated vesicle exocytosis. The Journal of Biological Chemistry. 282: 32613-22. PMID 17848561 DOI: 10.1074/jbc.M706591200  1
2007 Yazicioglu MN, Goad DL, Ranganathan A, Whitehurst AW, Goldsmith EJ, Cobb MH. Mutations in ERK2 binding sites affect nuclear entry. The Journal of Biological Chemistry. 282: 28759-67. PMID 17656361 DOI: 10.1074/jbc.M703460200  1
2007 Lawrence MC, McGlynn K, Naziruddin B, Levy MF, Cobb MH. Differential regulation of CHOP-10/GADD153 gene expression by MAPK signaling in pancreatic beta-cells. Proceedings of the National Academy of Sciences of the United States of America. 104: 11518-25. PMID 17615236 DOI: 10.1073/pnas.0704618104  1
2007 Raman M, Earnest S, Zhang K, Zhao Y, Cobb MH. TAO kinases mediate activation of p38 in response to DNA damage. The Embo Journal. 26: 2005-14. PMID 17396146 DOI: 10.1038/sj.emboj.7601668  1
2007 Lee BH, Chen W, Stippec S, Cobb MH. Biological cross-talk between WNK1 and the transforming growth factor beta-Smad signaling pathway. The Journal of Biological Chemistry. 282: 17985-96. PMID 17392271 DOI: 10.1074/jbc.M702664200  1
2007 Casar B, Sanz-Moreno V, Yazicioglu MN, Rodríguez J, Berciano MT, Lafarga M, Cobb MH, Crespo P. Mxi2 promotes stimulus-independent ERK nuclear translocation. The Embo Journal. 26: 635-46. PMID 17255949 DOI: 10.1038/sj.emboj.7601523  1
2006 Wilsbacher JL, Juang YC, Khokhlatchev AV, Gallagher E, Binns D, Goldsmith EJ, Cobb MH. Characterization of mitogen-activated protein kinase (MAPK) dimers. Biochemistry. 45: 13175-82. PMID 17073439 DOI: 10.1021/bi061041w  1
2006 Heise CJ, Cobb MH. Expression and characterization of MAP kinases in bacteria. Methods (San Diego, Calif.). 40: 209-12. PMID 16908184 DOI: 10.1016/j.ymeth.2006.06.012  1
2006 Anselmo AN, Earnest S, Chen W, Juang YC, Kim SC, Zhao Y, Cobb MH. WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells. Proceedings of the National Academy of Sciences of the United States of America. 103: 10883-8. PMID 16832045 DOI: 10.1073/pnas.0604607103  1
2006 Polychronopoulos S, Verykokakis M, Yazicioglu MN, Sakarellos-Daitsiotis M, Cobb MH, Mavrothalassitis G. The transcriptional ETS2 repressor factor associates with active and inactive Erks through distinct FXF motifs. The Journal of Biological Chemistry. 281: 25601-11. PMID 16799155 DOI: 10.1074/jbc.M605185200  1
2006 Xie J, Craig L, Cobb MH, Huang CL. Role of with-no-lysine [K] kinases in the pathogenesis of Gordon's syndrome. Pediatric Nephrology (Berlin, Germany). 21: 1231-6. PMID 16683163 DOI: 10.1007/s00467-006-0106-6  1
2006 Ranganathan A, Pearson GW, Chrestensen CA, Sturgill TW, Cobb MH. The MAP kinase ERK5 binds to and phosphorylates p90 RSK. Archives of Biochemistry and Biophysics. 449: 8-16. PMID 16626623 DOI: 10.1016/j.abb.2006.02.023  1
2006 Ranganathan A, Yazicioglu MN, Cobb MH. The nuclear localization of ERK2 occurs by mechanisms both independent of and dependent on energy. The Journal of Biological Chemistry. 281: 15645-52. PMID 16595679 DOI: 10.1074/jbc.M513866200  1
2006 Pearson GW, Earnest S, Cobb MH. Cyclic AMP selectively uncouples mitogen-activated protein kinase cascades from activating signals. Molecular and Cellular Biology. 26: 3039-47. PMID 16581779 DOI: 10.1128/MCB.26.8.3039-3047.2006  1
2006 Gibson TB, Lawrence MC, Gibson CJ, Vanderbilt CA, McGlynn K, Arnette D, Chen W, Collins J, Naziruddin B, Levy MF, Ehrlich BE, Cobb MH. Inhibition of glucose-stimulated activation of extracellular signal-regulated protein kinases 1 and 2 by epinephrine in pancreatic beta-cells. Diabetes. 55: 1066-73. PMID 16567530 DOI: 10.2337/diabetes.55.04.06.db05-1266  1
2006 Raman M, Cobb MH. TGF-beta regulation by Emilin1: new links in the etiology of hypertension. Cell. 124: 893-5. PMID 16530037 DOI: 10.1016/j.cell.2006.02.031  1
2006 Chen Z, Cobb MH. Activation of MEKK1 by Rho GTPases. Methods in Enzymology. 406: 468-78. PMID 16472679 DOI: 10.1016/S0076-6879(06)06035-6  1
2005 Xu BE, Stippec S, Lazrak A, Huang CL, Cobb MH. WNK1 activates SGK1 by a phosphatidylinositol 3-kinase-dependent and non-catalytic mechanism. The Journal of Biological Chemistry. 280: 34218-23. PMID 16081417 DOI: 10.1074/jbc.M505735200  1
2005 Xu BE, Stippec S, Chu PY, Lazrak A, Li XJ, Lee BH, English JM, Ortega B, Huang CL, Cobb MH. WNK1 activates SGK1 to regulate the epithelial sodium channel. Proceedings of the National Academy of Sciences of the United States of America. 102: 10315-20. PMID 16006511 DOI: 10.1073/pnas.0504422102  1
2005 Lawrence MC, McGlynn K, Park BH, Cobb MH. ERK1/2-dependent activation of transcription factors required for acute and chronic effects of glucose on the insulin gene promoter. The Journal of Biological Chemistry. 280: 26751-9. PMID 15899886 DOI: 10.1074/jbc.M503158200  1
2005 Lenertz LY, Lee BH, Min X, Xu BE, Wedin K, Earnest S, Goldsmith EJ, Cobb MH. Properties of WNK1 and implications for other family members. The Journal of Biological Chemistry. 280: 26653-8. PMID 15883153 DOI: 10.1074/jbc.M502598200  0.52
2005 Dufton C, Marcora E, Chae JH, McCullough J, Eby J, Hausburg M, Stein GH, Khoo S, Cobb MH, Lee JE. Context-dependent regulation of NeuroD activity and protein accumulation. Molecular and Cellular Neurosciences. 28: 727-36. PMID 15797719 DOI: 10.1016/j.mcn.2004.12.004  1
2005 Xu BE, Lee BH, Min X, Lenertz L, Heise CJ, Stippec S, Goldsmith EJ, Cobb MH. WNK1: analysis of protein kinase structure, downstream targets, and potential roles in hypertension. Cell Research. 15: 6-10. PMID 15686619 DOI: 10.1038/sj.cr.7290256  0.76
2004 Whitehurst A, Cobb MH, White MA. Stimulus-coupled spatial restriction of extracellular signal-regulated kinase 1/2 activity contributes to the specificity of signal-response pathways. Molecular and Cellular Biology. 24: 10145-50. PMID 15542825 DOI: 10.1128/MCB.24.23.10145-10150.2004  1
2004 Zhou T, Raman M, Gao Y, Earnest S, Chen Z, Machius M, Cobb MH, Goldsmith EJ. Crystal structure of the TAO2 kinase domain: activation and specificity of a Ste20p MAP3K. Structure (London, England : 1993). 12: 1891-900. PMID 15458637 DOI: 10.1016/j.str.2004.07.021  1
2004 Lee BH, Min X, Heise CJ, Xu BE, Chen S, Shu H, Luby-Phelps K, Goldsmith EJ, Cobb MH. WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding. Molecular Cell. 15: 741-51. PMID 15350218 DOI: 10.1016/j.molcel.2004.07.018  0.36
2004 Khoo S, Gibson TB, Arnette D, Lawrence M, January B, McGlynn K, Vanderbilt CA, Griffen SC, German MS, Cobb MH. MAP kinases and their roles in pancreatic beta-cells. Cell Biochemistry and Biophysics. 40: 191-200. PMID 15289654  0.84
2004 Anselmo AN, Cobb MH. Protein kinase function and glutathionylation. The Biochemical Journal. 381: e1-2. PMID 15270699 DOI: 10.1042/BJ20040873  1
2004 Min X, Lee BH, Cobb MH, Goldsmith EJ. Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension. Structure (London, England : 1993). 12: 1303-11. PMID 15242606 DOI: 10.1016/j.str.2004.04.014  1
2004 Goldsmith EJ, Cobb MH, Chang CI. Structure of MAPKs. Methods in Molecular Biology (Clifton, N.J.). 250: 127-44. PMID 14755085 DOI: 10.1385/1-59259-671-1:127  1
2004 Whitehurst AW, Robinson FL, Moore MS, Cobb MH. The death effector domain protein PEA-15 prevents nuclear entry of ERK2 by inhibiting required interactions. The Journal of Biological Chemistry. 279: 12840-7. PMID 14707138 DOI: 10.1074/jbc.M310031200  1
2004 Chen W, Yazicioglu M, Cobb MH. Characterization of OSR1, a member of the mammalian Ste20p/germinal center kinase subfamily. The Journal of Biological Chemistry. 279: 11129-36. PMID 14707132 DOI: 10.1074/jbc.M313562200  1
2004 Xu BE, Stippec S, Lenertz L, Lee BH, Zhang W, Lee YK, Cobb MH. WNK1 activates ERK5 by an MEKK2/3-dependent mechanism. The Journal of Biological Chemistry. 279: 7826-31. PMID 14681216 DOI: 10.1074/jbc.M313465200  1
2004 Gallagher ED, Gutowski S, Sternweis PC, Cobb MH. RhoA binds to the amino terminus of MEKK1 and regulates its kinase activity. The Journal of Biological Chemistry. 279: 1872-7. PMID 14581471 DOI: 10.1074/jbc.M309525200  1
2003 Raman M, Cobb MH. MAP kinase modules: many roads home. Current Biology : Cb. 13: R886-8. PMID 14614847 DOI: 10.1016/j.cub.2003.10.053  1
2003 Khoo S, Griffen SC, Xia Y, Baer RJ, German MS, Cobb MH. Regulation of insulin gene transcription by ERK1 and ERK2 in pancreatic beta cells. The Journal of Biological Chemistry. 278: 32969-77. PMID 12810726 DOI: 10.1074/jbc.M301198200  1
2003 Arnette D, Gibson TB, Lawrence MC, January B, Khoo S, McGlynn K, Vanderbilt CA, Cobb MH. Regulation of ERK1 and ERK2 by glucose and peptide hormones in pancreatic beta cells. The Journal of Biological Chemistry. 278: 32517-25. PMID 12783880 DOI: 10.1074/jbc.M301174200  1
2003 Chen Z, Raman M, Chen L, Lee SF, Gilman AG, Cobb MH. TAO (thousand-and-one amino acid) protein kinases mediate signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors. The Journal of Biological Chemistry. 278: 22278-83. PMID 12665513 DOI: 10.1074/jbc.M301173200  1
2002 Gilman AG, Simon MI, Bourne HR, Harris BA, Long R, Ross EM, Stull JT, Taussig R, Bourne HR, Arkin AP, Cobb MH, Cyster JG, Devreotes PN, Ferrell JE, Fruman D, et al. Overview of the Alliance for Cellular Signaling. Nature. 420: 703-6. PMID 12478301 DOI: 10.1038/nature01304  0.56
2002 Xu BE, Min X, Stippec S, Lee BH, Goldsmith EJ, Cobb MH. Regulation of WNK1 by an autoinhibitory domain and autophosphorylation. The Journal of Biological Chemistry. 277: 48456-62. PMID 12374799 DOI: 10.1074/jbc.M207917200  1
2002 Chen W, White MA, Cobb MH. Stimulus-specific requirements for MAP3 kinases in activating the JNK pathway. The Journal of Biological Chemistry. 277: 49105-10. PMID 12351623 DOI: 10.1074/jbc.M204934200  1
2002 Pearson GW, Cobb MH. Cell condition-dependent regulation of ERK5 by cAMP. The Journal of Biological Chemistry. 277: 48094-8. PMID 12297510 DOI: 10.1074/jbc.M208535200  1
2002 Gallagher ED, Xu S, Moomaw C, Slaughter CA, Cobb MH. Binding of JNK/SAPK to MEKK1 is regulated by phosphorylation. The Journal of Biological Chemistry. 277: 45785-92. PMID 12228228 DOI: 10.1074/jbc.M207702200  1
2002 Christerson LB, Gallagher E, Vanderbilt CA, Whitehurst AW, Wells C, Kazempour R, Sternweis PC, Cobb MH. p115 Rho GTPase activating protein interacts with MEKK1. Journal of Cellular Physiology. 192: 200-8. PMID 12115726 DOI: 10.1002/jcp.10125  0.56
2002 Chang CI, Xu BE, Akella R, Cobb MH, Goldsmith EJ. Crystal structures of MAP kinase p38 complexed to the docking sites on its nuclear substrate MEF2A and activator MKK3b. Molecular Cell. 9: 1241-9. PMID 12086621 DOI: 10.1016/S1097-2765(02)00525-7  1
2002 Lu Z, Xu S, Joazeiro C, Cobb MH, Hunter T. The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2. Molecular Cell. 9: 945-56. PMID 12049732 DOI: 10.1016/S1097-2765(02)00519-1  1
2002 Whitehurst AW, Wilsbacher JL, You Y, Luby-Phelps K, Moore MS, Cobb MH. ERK2 enters the nucleus by a carrier-independent mechanism. Proceedings of the National Academy of Sciences of the United States of America. 99: 7496-501. PMID 12032311 DOI: 10.1073/pnas.112495999  1
2002 Berman KS, Verma UN, Harburg G, Minna JD, Cobb MH, Gaynor RB. Sulindac enhances tumor necrosis factor-alpha-mediated apoptosis of lung cancer cell lines by inhibition of nuclear factor-kappaB. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 8: 354-60. PMID 11839649  1
2002 Robinson FL, Whitehurst AW, Raman M, Cobb MH. Identification of novel point mutations in ERK2 that selectively disrupt binding to MEK1. The Journal of Biological Chemistry. 277: 14844-52. PMID 11823456 DOI: 10.1074/jbc.M107776200  1
2002 English JM, Cobb MH. Pharmacological inhibitors of MAPK pathways. Trends in Pharmacological Sciences. 23: 40-5. PMID 11804650 DOI: 10.1016/S0165-6147(00)01865-4  1
2002 Robinson MJ, Xu Be BE, Stippec S, Cobb MH. Different domains of the mitogen-activated protein kinases ERK3 and ERK2 direct subcellular localization and upstream specificity in vivo. The Journal of Biological Chemistry. 277: 5094-100. PMID 11741894 DOI: 10.1074/jbc.M110935200  1
1996 Cobb MH, Xu S, Cheng M, Ebert D, Robbins D, Goldsmith E, Robinson M. Structural analysis of the MAP kinase ERK2 and studies of MAP kinase regulatory pathways. Advances in Pharmacology (San Diego, Calif.). 36: 49-65. PMID 8783554 DOI: 10.1016/S1054-3589(08)60576-1  1
1996 Xu S, Robbins DJ, Christerson LB, English JM, Vanderbilt CA, Cobb MH. Cloning of rat MEK kinase 1 cDNA reveals an endogenous membrane-associated 195-kDa protein with a large regulatory domain. Proceedings of the National Academy of Sciences of the United States of America. 93: 5291-5. PMID 8643568 DOI: 10.1073/pnas.93.11.5291  1
1995 Xu S, Robbins D, Frost J, Dang A, Lange-Carter C, Cobb MH. MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinase. Proceedings of the National Academy of Sciences of the United States of America. 92: 6808-12. PMID 7624324 DOI: 10.1073/pnas.92.15.6808  1
1995 Marcus S, Polverino A, Chang E, Robbins D, Cobb MH, Wigler MH. Shk1, a homolog of the Saccharomyces cerevisiae Ste20 and mammalian p65PAK protein kinases, is a component of a Ras/Cdc42 signaling module in the fission yeast Schizosaccharomyces pombe. Proceedings of the National Academy of Sciences of the United States of America. 92: 6180-4. PMID 7597098  1
1994 Zhang F, Strand A, Robbins D, Cobb MH, Goldsmith EJ. Atomic structure of the MAP kinase ERK2 at 2.3 A resolution. Nature. 367: 704-11. PMID 8107865 DOI: 10.1038/367704a0  1
1994 Robbins DJ, Zhen E, Cheng M, Xu S, Ebert D, Cobb MH. MAP kinases ERK1 and ERK2: pleiotropic enzymes in a ubiquitous signaling network. Advances in Cancer Research. 63: 93-116. PMID 8036991  1
1994 Cobb MH, Xu S, Hepler JE, Hutchison M, Frost J, Robbins DJ. Regulation of the MAP kinase cascade. Cellular & Molecular Biology Research. 40: 253-6. PMID 7874203  1
1994 Cobb MH, Hepler JE, Cheng M, Robbins D. The mitogen-activated protein kinases, ERK1 and ERK2. Seminars in Cancer Biology. 5: 261-8. PMID 7803762  1
1993 Robbins DJ, Zhen E, Owaki H, Vanderbilt CA, Ebert D, Geppert TD, Cobb MH. Regulation and properties of extracellular signal-regulated protein kinases 1 and 2 in vitro. The Journal of Biological Chemistry. 268: 5097-106. PMID 8444886  1
1993 Zhang F, Robbins DJ, Cobb MH, Goldsmith EJ. Crystallization and preliminary X-ray studies of extracellular signal-regulated kinase-2/MAP kinase with an incorporated His-tag. Journal of Molecular Biology. 233: 550-2. PMID 8411162 DOI: 10.1006/jmbi.1993.1532  1
1993 Robbins DJ, Zhen E, Cheng M, Xu S, Vanderbilt CA, Ebert D, Garcia C, Dang A, Cobb MH. Regulation and properties of extracellular signal-regulated protein kinases 1, 2, and 3. Journal of the American Society of Nephrology : Jasn. 4: 1104-10. PMID 8305637  0.88
1992 Robbins DJ, Cobb MH. Extracellular signal-regulated kinases 2 autophosphorylates on a subset of peptides phosphorylated in intact cells in response to insulin and nerve growth factor: analysis by peptide mapping. Molecular Biology of the Cell. 3: 299-308. PMID 1627831  1
1992 Robbins DJ, Cheng M, Zhen E, Vanderbilt CA, Feig LA, Cobb MH. Evidence for a Ras-dependent extracellular signal-regulated protein kinase (ERK) cascade. Proceedings of the National Academy of Sciences of the United States of America. 89: 6924-8. PMID 1495981  1
1992 Ahn NG, Robbins DJ, Haycock JW, Seger R, Cobb MH, Krebs EG. Identification of an activator of the microtubule-associated protein 2 kinases ERK1 and ERK2 in PC12 cells stimulated with nerve growth factor or bradykinin. Journal of Neurochemistry. 59: 147-56. PMID 1319464  1
1991 Boulton TG, Nye SH, Robbins DJ, Ip NY, Radziejewska E, Morgenbesser SD, DePinho RA, Panayotatos N, Cobb MH, Yancopoulos GD. ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell. 65: 663-75. PMID 2032290 DOI: 10.1016/0092-8674(91)90098-J  0.88
1991 Cobb MH, Boulton TG, Robbins DJ. Extracellular signal-regulated kinases: ERKs in progress. Cell Regulation. 2: 965-78. PMID 1801927  1
1991 Cobb MH, Robbins DJ, Boulton TG. ERKs, extracellular signal-regulated MAP-2 kinases. Current Opinion in Cell Biology. 3: 1025-32. PMID 1667578 DOI: 10.1016/0955-0674(91)90124-H  1
Show low-probability matches.