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Melanie Cobb - Publications

Affiliations: 
Pharmacology University of Texas Southwestern Medical Center, Dallas, TX, United States 
Website:
http://www.utsouthwestern.edu/fis/faculty/11375/melanie-cobb.html

199 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Jaykumar AB, Plumber S, Binns D, Wichaidit C, Luby-Phelps K, Cobb MH. SMURF1/2 are novel regulators of WNK1 stability. Biorxiv : the Preprint Server For Biology. PMID 39131382 DOI: 10.1101/2024.07.31.606092  0.302
2024 Taylor CA, Jung JU, Kankanamalage SG, Li J, Grzemska M, Jaykumar AB, Earnest S, Stippec S, Saha P, Sauceda E, Cobb MH. Predictive and Experimental Motif Interaction Analysis Identifies Functions of the WNK-OSR1/SPAK Pathway. Biorxiv : the Preprint Server For Biology. PMID 38979344 DOI: 10.1101/2024.06.26.600905  0.8
2024 Delgado M, Gallegos Z, Stippec S, McGlynn K, Cobb MH, Whitehurst AW. Testis Specific Serine Kinase 6 (TSSK6) is abnormally expressed in colorectal cancer and promotes oncogenic behaviors. The Journal of Biological Chemistry. 107380. PMID 38762178 DOI: 10.1016/j.jbc.2024.107380  0.703
2024 Delgado M, Stippec S, McGlynn K, Cobb MH, Whitehurst AW. The Cancer Testis Antigen Testis Specific Serine Kinase 6 (TSSK6) is abnormally expressed in colorectal cancer and is essential for oncogenic behaviors. Biorxiv : the Preprint Server For Biology. PMID 38260312 DOI: 10.1101/2024.01.08.574658  0.707
2024 Barylko B, Taylor CA, Wang J, Earnest S, Stippec S, Binns DD, Brautigam CA, Jameson DM, DeMartino GN, Cobb MH, Albanesi JP. Mimicking Protein Kinase C Phosphorylation Inhibits Arc/Arg3.1 Palmitoylation and Its Interaction with Nucleic Acids. International Journal of Molecular Sciences. 25. PMID 38255853 DOI: 10.3390/ijms25020780  0.333
2023 Martin-Vega A, Cobb MH. Navigating the ERK1/2 MAPK Cascade. Biomolecules. 13. PMID 37892237 DOI: 10.3390/biom13101555  0.437
2023 Martin-Vega A, Earnest S, Augustyn A, Wichaidit C, Gazdar A, Girard L, Peyton M, Kollipara RK, Minna JD, Johnson JE, Cobb MH. ASCL1-ERK1/2 Axis: ASCL1 restrains ERK1/2 via the dual specificity phosphatase DUSP6 to promote survival of a subset of neuroendocrine lung cancers. Biorxiv : the Preprint Server For Biology. PMID 37398419 DOI: 10.1101/2023.06.15.545148  0.3
2023 Jung JU, Cobb MH. WNK1 controls endosomal trafficking through TRIM27-dependent regulation of actin assembly. Proceedings of the National Academy of Sciences of the United States of America. 120: e2300310120. PMID 37307465 DOI: 10.1073/pnas.2300310120  0.375
2023 Kalwat MA, Rodrigues-Dos-Santos K, Binns DD, Wei S, Zhou A, Evans MR, Posner BA, Roth MG, Cobb MH. Small molecule glucagon release inhibitors with activity in human islets. Frontiers in Endocrinology. 14: 1114799. PMID 37152965 DOI: 10.3389/fendo.2023.1114799  0.722
2022 Jaykumar AB, Plumber S, Barry DM, Binns D, Wichaidit C, Grzemska M, Earnest S, Goldsmith EJ, Cleaver O, Cobb MH. WNK1 collaborates with TGF-β in endothelial cell junction turnover and angiogenesis. Proceedings of the National Academy of Sciences of the United States of America. 119: e2203743119. PMID 35867836 DOI: 10.1073/pnas.2203743119  0.8
2022 Rodrigues-Dos-Santos K, Roy G, Binns DD, Grzemska MG, Barella LF, Armoo F, McCoy MK, Huynh AV, Yang JZ, Posner BA, Cobb MH, Kalwat MA. Small molecule-mediated insulin hypersecretion induces transient ER stress response and loss of beta cell function. Endocrinology. PMID 35641126 DOI: 10.1210/endocr/bqac081  0.771
2021 Wang XD, Kim C, Zhang Y, Rindhe S, Cobb MH, Yu Y. Cholesterol Regulates the Tumor Adaptive Resistance to MAPK Pathway Inhibition. Journal of Proteome Research. PMID 34751028 DOI: 10.1021/acs.jproteome.1c00550  0.326
2021 Kalwat MA, Scheuner D, Rodrigues Dos Santos K, Eizirik DL, Cobb MH. The pancreatic β cell response to secretory demands and adaption to stress. Endocrinology. PMID 34407177 DOI: 10.1210/endocr/bqab173  0.742
2021 Taylor CA, Cobb MH. . Molecular Pharmacology. PMID 34312216 DOI: 10.1124/molpharm.121.000307  0.312
2021 Jaykumar AB, Jung JU, Parida PK, Dang TT, Wichaidit C, Kannangara AR, Earnest S, Goldsmith EJ, Pearson GW, Malladi S, Cobb MH. WNK1 Enhances Migration and Invasion in Breast Cancer Models. Molecular Cancer Therapeutics. PMID 34253593 DOI: 10.1158/1535-7163.MCT-21-0174  0.69
2020 Liu Z, Yoon J, Wichaidit C, Jaykumar AB, Dbouk HA, Embry AE, Liu L, Henderson JM, Chang AN, Cobb MH, Miller RT. Control of Podocyte and Glomerular Capillary Wall Structure and Elasticity by WNK1 Kinase. Frontiers in Cell and Developmental Biology. 8: 618898. PMID 33604334 DOI: 10.3389/fcell.2020.618898  0.309
2020 Kalwat MA, Huang Z, Binns DD, McGlynn K, Cobb MH. α-Adrenergic Disruption of β Cell BDNF-TrkB Receptor Tyrosine Kinase Signaling. Frontiers in Cell and Developmental Biology. 8: 576396. PMID 33178692 DOI: 10.3389/fcell.2020.576396  0.792
2019 Shen C, Li B, Astudillo L, Deutscher MP, Cobb MH, Capobianco AJ, Lee E, Robbins DJ. The CK1α Activator Pyrvinium Enhances the Catalytic Efficiency (/) of CK1α. Biochemistry. PMID 31820934 DOI: 10.1021/Acs.Biochem.9B00891  0.623
2019 Kalwat M, Cobb MH. Measuring Relative Insulin Secretion using a Co-Secreted Luciferase Surrogate. Journal of Visualized Experiments : Jove. PMID 31305532 DOI: 10.3791/59926  0.709
2018 Gallolu Kankanamalage S, Karra AS, Cobb MH. WNK pathways in cancer signaling networks. Cell Communication and Signaling : Ccs. 16: 72. PMID 30390653 DOI: 10.1186/s12964-018-0287-1  0.815
2018 Kalwat MA, Hwang IH, Macho J, Grzemska MG, Yang JZ, McGlynn K, MacMillan JB, Cobb MH. Chromomycin A potently inhibits glucose-stimulated insulin secretion from pancreatic β cells. The Journal of General Physiology. PMID 30352794 DOI: 10.1085/Jgp.201812177  0.789
2018 Jaykumar AB, Karra AS, Cobb MH. Pulling a MAST1 on Cisplatin Resistance. Cancer Cell. 34: 183-185. PMID 30107173 DOI: 10.1016/j.ccell.2018.07.010  0.799
2018 Thorne CA, Chen IW, Sanman LE, Cobb MH, Wu LF, Altschuler SJ. Enteroid Monolayers Reveal an Autonomous WNT and BMP Circuit Controlling Intestinal Epithelial Growth and Organization. Developmental Cell. PMID 29503158 DOI: 10.1016/J.Devcel.2018.01.024  0.665
2017 Kalwat MA, Wichaidit C, Nava Garcia AY, McCoy MK, McGlynn K, Hwang IH, MacMillan JB, Posner BA, Cobb MH. Correction to Insulin Promoter-Driven Gaussia Luciferase-Based Insulin Secretion Biosensor Assay for Discovery of β-Cell Glucose-Sensing Pathways. Acs Sensors. 2: 316. PMID 28723136 DOI: 10.1021/acssensors.7b00012  0.729
2017 Li B, Orton D, Neitzel LR, Astudillo L, Shen C, Long J, Chen X, Kirkbride KC, Doundoulakis T, Guerra ML, Zaias J, Fei DL, Rodriguez-Blanco J, Thorne C, Wang Z, ... ... Cobb MH, et al. Differential abundance of CK1α provides selectivity for pharmacological CK1α activators to target WNT-dependent tumors. Science Signaling. 10. PMID 28655862 DOI: 10.1126/Scisignal.Aak9916  0.796
2017 Karra AS, Stippec S, Cobb MH. Assaying Protein Kinase Activity with Radiolabeled ATP. Journal of Visualized Experiments : Jove. PMID 28605363 DOI: 10.3791/55504  0.821
2017 Kalwat MA, Cobb M. Mechanisms of the Amplifying Pathway of Insulin Secretion in the β Cell. Pharmacology & Therapeutics. PMID 28527919 DOI: 10.1016/j.pharmthera.2017.05.003  0.74
2017 Gallolu Kankanamalage S, Lee AY, Wichaidit C, Lorente-Rodriguez A, Shah AM, Stippec S, Whitehurst AW, Cobb MH. WNK1 is an unexpected autophagy inhibitor. Autophagy. 1-2. PMID 28282258 DOI: 10.1080/15548627.2017.1286431  0.748
2017 Guerra ML, Kalwat MA, McGlynn K, Cobb MH. Sucralose activates an ERK1/2-ribosomal protein S6 signaling axis. Febs Open Bio. 7: 174-186. PMID 28174684 DOI: 10.1002/2211-5463.12172  0.834
2016 Gallolu Kankanamalage S, Lee AY, Wichaidit C, Lorente-Rodriguez A, Shah AM, Stippec S, Whitehurst AW, Cobb MH. Multistep regulation of autophagy by WNK1. Proceedings of the National Academy of Sciences of the United States of America. PMID 27911840 DOI: 10.1073/pnas.1617649113  0.762
2016 Kalwat MA, Wichaidit C, Nava Garcia AY, McCoy MK, McGlynn K, Hwang IH, MacMillan JB, Posner BA, Cobb MH. Insulin promoter-driven Gaussia luciferase-based insulin secretion biosensor assay for discovery of β-cell glucose-sensing pathways. Acs Sensors. 1: 1208-1212. PMID 27819058 DOI: 10.1021/Acssensors.6B00433  0.73
2016 McReynolds AC, Karra AS, Li Y, Lopez ED, Turjanski AG, Dioum E, Lorenz K, Zaganjor E, Stippec S, McGlynn K, Earnest S, Cobb MH. Phosphorylation or mutation of the ERK2 activation loop alters oligonucleotide binding. Biochemistry. PMID 26950759 DOI: 10.1021/Acs.Biochem.6B00096  0.814
2016 Kalwat MA, Huang Z, Wichaidit C, McGlynn K, Earnest S, Savoia C, Dioum EM, Schneider JW, Hutchison MR, Cobb MH. Isoxazole alters metabolites and gene expression, decreasing proliferation and promoting a neuroendocrine phenotype in β-cells. Acs Chemical Biology. PMID 26828310 DOI: 10.1021/acschembio.5b00993  0.736
2015 Karra AS, Taylor CA, Thorne CA, Cobb MH. A Kinase Divided. Cancer Cell. 28: 145-7. PMID 26267529 DOI: 10.1016/J.Ccell.2015.07.008  0.82
2015 Taylor CA, Juang YC, Earnest S, Sengupta S, Goldsmith EJ, Cobb MH. Domain-Swapping Switch Point in Ste20 Protein Kinase SPAK. Biochemistry. PMID 26208601 DOI: 10.1021/Acs.Biochem.5B00593  0.307
2015 Wauson EM, Guerra ML, Dyachok J, McGlynn K, Giles J, Ross EM, Cobb MH. Differential Regulation of ERK1/2 and mTORC1 Through T1R1/T1R3 in MIN6 Cells. Molecular Endocrinology (Baltimore, Md.). 29: 1114-22. PMID 26168033 DOI: 10.1210/Me.2014-1181  0.828
2014 Dbouk HA, Weil LM, Perera GK, Dellinger MT, Pearson G, Brekken RA, Cobb MH. Actions of the protein kinase WNK1 on endothelial cells are differentially mediated by its substrate kinases OSR1 and SPAK. Proceedings of the National Academy of Sciences of the United States of America. 111: 15999-6004. PMID 25362046 DOI: 10.1073/Pnas.1419057111  0.748
2014 Klein AM, Cobb MH. ERK5 signaling gets XIAPed: a role for ubiquitin in the disassembly of a MAPK cascade. The Embo Journal. 33: 1735-6. PMID 25012518 DOI: 10.15252/embj.201489205  0.569
2014 Zaganjor E, Weil LM, Gonzales JX, Minna JD, Cobb MH. Ras transformation uncouples the kinesin-coordinated cellular nutrient response. Proceedings of the National Academy of Sciences of the United States of America. 111: 10568-73. PMID 25002494 DOI: 10.1073/Pnas.1411016111  0.71
2014 Piala AT, Moon TM, Akella R, He H, Cobb MH, Goldsmith EJ. Chloride sensing by WNK1 involves inhibition of autophosphorylation. Science Signaling. 7: ra41. PMID 24803536 DOI: 10.1126/Scisignal.2005050  0.313
2014 Wauson EM, Dbouk HA, Ghosh AB, Cobb MH. G protein-coupled receptors and the regulation of autophagy. Trends in Endocrinology and Metabolism: Tem. 25: 274-82. PMID 24751357 DOI: 10.1016/J.Tem.2014.03.006  0.741
2014 Osborne JK, Guerra ML, Gonzales JX, McMillan EA, Minna JD, Cobb MH. NeuroD1 mediates nicotine-induced migration and invasion via regulation of the nicotinic acetylcholine receptor subunits in a subset of neural and neuroendocrine carcinomas. Molecular Biology of the Cell. 25: 1782-92. PMID 24719457 DOI: 10.1091/Mbc.E13-06-0316  0.634
2014 Guerra ML, Wauson EM, McGlynn K, Cobb MH. Muscarinic control of MIN6 pancreatic β cells is enhanced by impaired amino acid signaling. The Journal of Biological Chemistry. 289: 14370-9. PMID 24695728 DOI: 10.1074/Jbc.M114.565069  0.801
2014 Zaganjor E, Osborne JK, Weil LM, Diaz-Martinez LA, Gonzales JX, Singel SM, Larsen JE, Girard L, Minna JD, Cobb MH. Ras regulates kinesin 13 family members to control cell migration pathways in transformed human bronchial epithelial cells. Oncogene. 33: 5457-66. PMID 24240690 DOI: 10.1038/Onc.2013.486  0.689
2013 Sengupta S, Lorente-Rodríguez A, Earnest S, Stippec S, Guo X, Trudgian DC, Mirzaei H, Cobb MH. Regulation of OSR1 and the sodium, potassium, two chloride cotransporter by convergent signals. Proceedings of the National Academy of Sciences of the United States of America. 110: 18826-31. PMID 24191005 DOI: 10.1073/Pnas.1318676110  0.436
2013 Wauson EM, Guerra ML, Barylko B, Albanesi JP, Cobb MH. Off-target effects of MEK inhibitors. Biochemistry. 52: 5164-6. PMID 23848362 DOI: 10.1021/Bi4007644  0.822
2013 Wauson EM, Lorente-Rodríguez A, Cobb MH. Minireview: Nutrient sensing by G protein-coupled receptors. Molecular Endocrinology (Baltimore, Md.). 27: 1188-97. PMID 23820899 DOI: 10.1210/me.2013-1100  0.73
2013 Xu D, Cobb MG, Gavilano L, Witherspoon SM, Williams D, White CD, Taverna P, Bednarski BK, Kim HJ, Baldwin AS, Baines AT. Inhibition of oncogenic Pim-3 kinase modulates transformed growth and chemosensitizes pancreatic cancer cells to gemcitabine. Cancer Biology & Therapy. 14: 492-501. PMID 23760491 DOI: 10.4161/Cbt.24343  0.316
2013 Klein AM, Zaganjor E, Cobb MH. Chromatin-tethered MAPKs. Current Opinion in Cell Biology. 25: 272-7. PMID 23434067 DOI: 10.1016/J.Ceb.2013.01.002  0.803
2013 Wauson EM, Zaganjor E, Cobb MH. Amino acid regulation of autophagy through the GPCR TAS1R1-TAS1R3. Autophagy. 9: 418-9. PMID 23222068 DOI: 10.4161/Auto.22911  0.776
2012 Sengupta S, Tu SW, Wedin K, Earnest S, Stippec S, Luby-Phelps K, Cobb MH. Interactions with WNK (with no lysine) family members regulate oxidative stress response 1 and ion co-transporter activity. The Journal of Biological Chemistry. 287: 37868-79. PMID 22989884 DOI: 10.1074/jbc.M112.398750  0.314
2012 Wauson EM, Zaganjor E, Lee AY, Guerra ML, Ghosh AB, Bookout AL, Chambers CP, Jivan A, McGlynn K, Hutchison MR, Deberardinis RJ, Cobb MH. The G protein-coupled taste receptor T1R1/T1R3 regulates mTORC1 and autophagy. Molecular Cell. 47: 851-62. PMID 22959271 DOI: 10.1016/J.Molcel.2012.08.001  0.778
2012 Osborne JK, Zaganjor E, Cobb MH. Signal control through Raf: in sickness and in health. Cell Research. 22: 14-22. PMID 22143568 DOI: 10.1038/Cr.2011.193  0.761
2010 Klein AM, Dioum EM, Cobb MH. Exposing contingency plans for kinase networks. Cell. 143: 867-9. PMID 21145453 DOI: 10.1016/j.cell.2010.11.046  0.54
2010 Duan L, Cobb MH. Calcineurin increases glucose activation of ERK1/2 by reversing negative feedback. Proceedings of the National Academy of Sciences of the United States of America. 107: 22314-9. PMID 21135229 DOI: 10.1073/pnas.1016630108  0.309
2010 Heise CJ, Xu BE, Deaton SL, Cha SK, Cheng CJ, Earnest S, Sengupta S, Juang YC, Stippec S, Xu Y, Zhao Y, Huang CL, Cobb MH. Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members. The Journal of Biological Chemistry. 285: 25161-7. PMID 20525693 DOI: 10.1074/Jbc.M110.103432  0.373
2009 Dioum EM, Wauson EM, Cobb MH. MAP-ping unconventional protein-DNA interactions. Cell. 139: 462-3. PMID 19879834 DOI: 10.1016/j.cell.2009.10.007  0.73
2009 Jivan A, Earnest S, Juang YC, Cobb MH. Radial spoke protein 3 is a mammalian protein kinase A-anchoring protein that binds ERK1/2. The Journal of Biological Chemistry. 284: 29437-45. PMID 19684019 DOI: 10.1074/jbc.M109.048181  0.365
2009 Zheng Y, Xia Y, Hawke D, Halle M, Tremblay ML, Gao X, Zhou XZ, Aldape K, Cobb MH, Xie K, He J, Lu Z. FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST. Molecular Cell. 35: 11-25. PMID 19595712 DOI: 10.1016/J.Molcel.2009.06.013  0.302
2009 Min X, Akella R, He H, Humphreys JM, Tsutakawa SE, Lee SJ, Tainer JA, Cobb MH, Goldsmith EJ. The structure of the MAP2K MEK6 reveals an autoinhibitory dimer. Structure (London, England : 1993). 17: 96-104. PMID 19141286 DOI: 10.1016/J.Str.2008.11.007  0.334
2009 Chen W, Chen Y, Xu BE, Juang YC, Stippec S, Zhao Y, Cobb MH. Regulation of a third conserved phosphorylation site in SGK1. The Journal of Biological Chemistry. 284: 3453-60. PMID 19068477 DOI: 10.1074/Jbc.M807502200  0.414
2008 Lawrence MC, McGlynn K, Shao C, Duan L, Naziruddin B, Levy MF, Cobb MH. Chromatin-bound mitogen-activated protein kinases transmit dynamic signals in transcription complexes in beta-cells. Proceedings of the National Academy of Sciences of the United States of America. 105: 13315-20. PMID 18755896 DOI: 10.1073/pnas.0806465105  0.34
2008 Lawrence MC, Jivan A, Shao C, Duan L, Goad D, Zaganjor E, Osborne J, McGlynn K, Stippec S, Earnest S, Chen W, Cobb MH. The roles of MAPKs in disease. Cell Research. 18: 436-42. PMID 18347614 DOI: 10.1038/Cr.2008.37  0.755
2008 Lawrence M, Shao C, Duan L, McGlynn K, Cobb MH. The protein kinases ERK1/2 and their roles in pancreatic beta cells. Acta Physiologica (Oxford, England). 192: 11-7. PMID 18171425 DOI: 10.1111/j.1748-1716.2007.01785.x  0.36
2007 Huang CL, Cha SK, Wang HR, Xie J, Cobb MH. WNKs: protein kinases with a unique kinase domain. Experimental & Molecular Medicine. 39: 565-73. PMID 18059132 DOI: 10.1038/emm.2007.62  0.373
2007 Oh E, Heise CJ, English JM, Cobb MH, Thurmond DC. WNK1 is a novel regulator of Munc18c-syntaxin 4 complex formation in soluble NSF attachment protein receptor (SNARE)-mediated vesicle exocytosis. The Journal of Biological Chemistry. 282: 32613-22. PMID 17848561 DOI: 10.1074/jbc.M706591200  0.663
2007 Yazicioglu MN, Goad DL, Ranganathan A, Whitehurst AW, Goldsmith EJ, Cobb MH. Mutations in ERK2 binding sites affect nuclear entry. The Journal of Biological Chemistry. 282: 28759-67. PMID 17656361 DOI: 10.1074/Jbc.M703460200  0.699
2007 Raman M, Chen W, Cobb MH. Differential regulation and properties of MAPKs. Oncogene. 26: 3100-12. PMID 17496909 DOI: 10.1038/sj.onc.1210392  0.446
2007 Raman M, Earnest S, Zhang K, Zhao Y, Cobb MH. TAO kinases mediate activation of p38 in response to DNA damage. The Embo Journal. 26: 2005-14. PMID 17396146 DOI: 10.1038/Sj.Emboj.7601668  0.359
2007 Lee BH, Chen W, Stippec S, Cobb MH. Biological cross-talk between WNK1 and the transforming growth factor beta-Smad signaling pathway. The Journal of Biological Chemistry. 282: 17985-96. PMID 17392271 DOI: 10.1074/jbc.M702664200  0.35
2007 Casar B, Sanz-Moreno V, Yazicioglu MN, Rodríguez J, Berciano MT, Lafarga M, Cobb MH, Crespo P. Mxi2 promotes stimulus-independent ERK nuclear translocation. The Embo Journal. 26: 635-46. PMID 17255949 DOI: 10.1038/sj.emboj.7601523  0.351
2006 Wilsbacher JL, Juang YC, Khokhlatchev AV, Gallagher E, Binns D, Goldsmith EJ, Cobb MH. Characterization of mitogen-activated protein kinase (MAPK) dimers. Biochemistry. 45: 13175-82. PMID 17073439 DOI: 10.1021/Bi061041W  0.349
2006 Heise CJ, Cobb MH. Expression and characterization of MAP kinases in bacteria. Methods (San Diego, Calif.). 40: 209-12. PMID 16908184 DOI: 10.1016/j.ymeth.2006.06.012  0.426
2006 Anselmo AN, Earnest S, Chen W, Juang YC, Kim SC, Zhao Y, Cobb MH. WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells. Proceedings of the National Academy of Sciences of the United States of America. 103: 10883-8. PMID 16832045 DOI: 10.1073/Pnas.0604607103  0.416
2006 Polychronopoulos S, Verykokakis M, Yazicioglu MN, Sakarellos-Daitsiotis M, Cobb MH, Mavrothalassitis G. The transcriptional ETS2 repressor factor associates with active and inactive Erks through distinct FXF motifs. The Journal of Biological Chemistry. 281: 25601-11. PMID 16799155 DOI: 10.1074/jbc.M605185200  0.382
2006 Ranganathan A, Pearson GW, Chrestensen CA, Sturgill TW, Cobb MH. The MAP kinase ERK5 binds to and phosphorylates p90 RSK. Archives of Biochemistry and Biophysics. 449: 8-16. PMID 16626623 DOI: 10.1016/J.Abb.2006.02.023  0.766
2006 Ranganathan A, Yazicioglu MN, Cobb MH. The nuclear localization of ERK2 occurs by mechanisms both independent of and dependent on energy. The Journal of Biological Chemistry. 281: 15645-52. PMID 16595679 DOI: 10.1074/jbc.M513866200  0.359
2006 Pearson GW, Earnest S, Cobb MH. Cyclic AMP selectively uncouples mitogen-activated protein kinase cascades from activating signals. Molecular and Cellular Biology. 26: 3039-47. PMID 16581779 DOI: 10.1128/MCB.26.8.3039-3047.2006  0.782
2006 You YJ, Kim J, Cobb M, Avery L. Starvation activates MAP kinase through the muscarinic acetylcholine pathway in Caenorhabditis elegans pharynx. Cell Metabolism. 3: 237-45. PMID 16581001 DOI: 10.1016/J.Cmet.2006.02.012  0.335
2006 Chen Z, Cobb MH. Activation of MEKK1 by Rho GTPases. Methods in Enzymology. 406: 468-78. PMID 16472679 DOI: 10.1016/S0076-6879(06)06035-6  0.433
2005 Xu BE, Stippec S, Lazrak A, Huang CL, Cobb MH. WNK1 activates SGK1 by a phosphatidylinositol 3-kinase-dependent and non-catalytic mechanism. The Journal of Biological Chemistry. 280: 34218-23. PMID 16081417 DOI: 10.1074/jbc.M505735200  0.394
2005 Lenertz LY, Lee BH, Min X, Xu BE, Wedin K, Earnest S, Goldsmith EJ, Cobb MH. Properties of WNK1 and implications for other family members. The Journal of Biological Chemistry. 280: 26653-8. PMID 15883153 DOI: 10.1074/Jbc.M502598200  0.333
2005 Xu BE, Lee BH, Min X, Lenertz L, Heise CJ, Stippec S, Goldsmith EJ, Cobb MH. WNK1: analysis of protein kinase structure, downstream targets, and potential roles in hypertension. Cell Research. 15: 6-10. PMID 15686619 DOI: 10.1038/Sj.Cr.7290256  0.346
2004 Whitehurst A, Cobb MH, White MA. Stimulus-coupled spatial restriction of extracellular signal-regulated kinase 1/2 activity contributes to the specificity of signal-response pathways. Molecular and Cellular Biology. 24: 10145-50. PMID 15542825 DOI: 10.1128/Mcb.24.23.10145-10150.2004  0.752
2004 Zhou T, Raman M, Gao Y, Earnest S, Chen Z, Machius M, Cobb MH, Goldsmith EJ. Crystal structure of the TAO2 kinase domain: activation and specificity of a Ste20p MAP3K. Structure (London, England : 1993). 12: 1891-900. PMID 15458637 DOI: 10.1016/J.Str.2004.07.021  0.381
2004 Khoo S, Gibson TB, Arnette D, Lawrence M, January B, McGlynn K, Vanderbilt CA, Griffen SC, German MS, Cobb MH. MAP kinases and their roles in pancreatic beta-cells. Cell Biochemistry and Biophysics. 40: 191-200. PMID 15289654 DOI: 10.1385/CBB:40:3:191  0.358
2004 Anselmo AN, Cobb MH. Protein kinase function and glutathionylation. The Biochemical Journal. 381: e1-2. PMID 15270699 DOI: 10.1042/BJ20040873  0.409
2004 Min X, Lee BH, Cobb MH, Goldsmith EJ. Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension. Structure (London, England : 1993). 12: 1303-11. PMID 15242606 DOI: 10.1016/J.Str.2004.04.014  0.314
2004 Whitehurst AW, Robinson FL, Moore MS, Cobb MH. The death effector domain protein PEA-15 prevents nuclear entry of ERK2 by inhibiting required interactions. The Journal of Biological Chemistry. 279: 12840-7. PMID 14707138 DOI: 10.1074/Jbc.M310031200  0.749
2004 Chen W, Yazicioglu M, Cobb MH. Characterization of OSR1, a member of the mammalian Ste20p/germinal center kinase subfamily. The Journal of Biological Chemistry. 279: 11129-36. PMID 14707132 DOI: 10.1074/jbc.M313562200  0.447
2004 Xu BE, Stippec S, Lenertz L, Lee BH, Zhang W, Lee YK, Cobb MH. WNK1 activates ERK5 by an MEKK2/3-dependent mechanism. The Journal of Biological Chemistry. 279: 7826-31. PMID 14681216 DOI: 10.1074/Jbc.M313465200  0.408
2004 Gallagher ED, Gutowski S, Sternweis PC, Cobb MH. RhoA binds to the amino terminus of MEKK1 and regulates its kinase activity. The Journal of Biological Chemistry. 279: 1872-7. PMID 14581471 DOI: 10.1074/Jbc.M309525200  0.385
2003 Khoo S, Griffen SC, Xia Y, Baer RJ, German MS, Cobb MH. Regulation of insulin gene transcription by ERK1 and ERK2 in pancreatic beta cells. The Journal of Biological Chemistry. 278: 32969-77. PMID 12810726 DOI: 10.1074/jbc.M301198200  0.31
2003 Chen Z, Raman M, Chen L, Lee SF, Gilman AG, Cobb MH. TAO (thousand-and-one amino acid) protein kinases mediate signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors. The Journal of Biological Chemistry. 278: 22278-83. PMID 12665513 DOI: 10.1074/Jbc.M301173200  0.415
2002 Gilman AG, Simon MI, Bourne HR, Harris BA, Long R, Ross EM, Stull JT, Taussig R, Bourne HR, Arkin AP, Cobb MH, Cyster JG, Devreotes PN, Ferrell JE, Fruman D, et al. Overview of the Alliance for Cellular Signaling. Nature. 420: 703-6. PMID 12478301 DOI: 10.1038/Nature01304  0.413
2002 Chen W, White MA, Cobb MH. Stimulus-specific requirements for MAP3 kinases in activating the JNK pathway. The Journal of Biological Chemistry. 277: 49105-10. PMID 12351623 DOI: 10.1074/jbc.M204934200  0.414
2002 Pearson GW, Cobb MH. Cell condition-dependent regulation of ERK5 by cAMP. The Journal of Biological Chemistry. 277: 48094-8. PMID 12297510 DOI: 10.1074/jbc.M208535200  0.786
2002 Gallagher ED, Xu S, Moomaw C, Slaughter CA, Cobb MH. Binding of JNK/SAPK to MEKK1 is regulated by phosphorylation. The Journal of Biological Chemistry. 277: 45785-92. PMID 12228228 DOI: 10.1074/jbc.M207702200  0.398
2002 Christerson LB, Gallagher E, Vanderbilt CA, Whitehurst AW, Wells C, Kazempour R, Sternweis PC, Cobb MH. p115 Rho GTPase activating protein interacts with MEKK1. Journal of Cellular Physiology. 192: 200-8. PMID 12115726 DOI: 10.1002/Jcp.10125  0.746
2002 Lu Z, Xu S, Joazeiro C, Cobb MH, Hunter T. The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2. Molecular Cell. 9: 945-56. PMID 12049732 DOI: 10.1016/S1097-2765(02)00519-1  0.56
2002 Whitehurst AW, Wilsbacher JL, You Y, Luby-Phelps K, Moore MS, Cobb MH. ERK2 enters the nucleus by a carrier-independent mechanism. Proceedings of the National Academy of Sciences of the United States of America. 99: 7496-501. PMID 12032311 DOI: 10.1073/Pnas.112495999  0.727
2002 Robinson FL, Whitehurst AW, Raman M, Cobb MH. Identification of novel point mutations in ERK2 that selectively disrupt binding to MEK1. The Journal of Biological Chemistry. 277: 14844-52. PMID 11823456 DOI: 10.1074/Jbc.M107776200  0.761
2002 English JM, Cobb MH. Pharmacological inhibitors of MAPK pathways. Trends in Pharmacological Sciences. 23: 40-5. PMID 11804650 DOI: 10.1016/S0165-6147(00)01865-4  0.401
2002 Robinson MJ, Xu Be BE, Stippec S, Cobb MH. Different domains of the mitogen-activated protein kinases ERK3 and ERK2 direct subcellular localization and upstream specificity in vivo. The Journal of Biological Chemistry. 277: 5094-100. PMID 11741894 DOI: 10.1074/jbc.M110935200  0.375
2001 Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH. MAP kinases. Chemical Reviews. 101: 2449-76. PMID 11749383 DOI: 10.1021/cr000241p  0.717
2001 Gallagher ED, Cobb MH. ERKs weigh in on ribosome mass. Molecular Cell. 8: 932-3. PMID 11741528 DOI: 10.1016/S1097-2765(01)00387-2  0.303
2001 Berman KS, Hutchison M, Avery L, Cobb MH. kin-18, a C. elegans protein kinase involved in feeding. Gene. 279: 137-47. PMID 11733138 DOI: 10.1016/S0378-1119(01)00752-1  0.399
2001 Berman K, McKay J, Avery L, Cobb M. Isolation and characterization of pmk-(1-3): three p38 homologs in Caenorhabditis elegans. Molecular Cell Biology Research Communications : McBrc. 4: 337-44. PMID 11703092 DOI: 10.1006/mcbr.2001.0300  0.338
2001 Xu Be, Stippec S, Robinson FL, Cobb MH. Hydrophobic as well as charged residues in both MEK1 and ERK2 are important for their proper docking. The Journal of Biological Chemistry. 276: 26509-15. PMID 11352917 DOI: 10.1074/Jbc.M102769200  0.311
2001 Wilsbacher JL, Cobb MH. Bacterial expression of activated mitogen-activated protein kinases. Methods in Enzymology. 332: 387-400. PMID 11305113 DOI: 10.1016/S0076-6879(01)32217-6  0.334
2001 Pearson G, Robinson F, Beers Gibson T, Xu BE, Karandikar M, Berman K, Cobb MH. Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocrine Reviews. 22: 153-83. PMID 11294822 DOI: 10.1210/Edrv.22.2.0428  0.765
2001 Chen Z, Cobb MH. Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2. The Journal of Biological Chemistry. 276: 16070-5. PMID 11279118 DOI: 10.1074/jbc.M100681200  0.409
2001 Pearson G, English JM, White MA, Cobb MH. ERK5 and ERK2 cooperate to regulate NF-kappaB and cell transformation. The Journal of Biological Chemistry. 276: 7927-31. PMID 11118448 DOI: 10.1074/Jbc.M009764200  0.758
2000 Pearson G, Bumeister R, Henry DO, Cobb MH, White MA. Uncoupling Raf1 from MEK1/2 impairs only a subset of cellular responses to Raf activation. The Journal of Biological Chemistry. 275: 37303-6. PMID 11018021 DOI: 10.1074/Jbc.C000570200  0.782
2000 Karandikar M, Xu S, Cobb MH. MEKK1 binds raf-1 and the ERK2 cascade components. The Journal of Biological Chemistry. 275: 40120-7. PMID 10969079 DOI: 10.1074/jbc.M005926200  0.423
2000 Lee HY, Suh YA, Robinson MJ, Clifford JL, Hong WK, Woodgett JR, Cobb MH, Mangelsdorf DJ, Kurie JM. Stress pathway activation induces phosphorylation of retinoid X receptor. The Journal of Biological Chemistry. 275: 32193-9. PMID 10938283 DOI: 10.1074/Jbc.M005490200  0.416
2000 Xu B, English JM, Wilsbacher JL, Stippec S, Goldsmith EJ, Cobb MH. WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II. The Journal of Biological Chemistry. 275: 16795-801. PMID 10828064 DOI: 10.1074/Jbc.275.22.16795  0.387
2000 Nichols A, Camps M, Gillieron C, Chabert C, Brunet A, Wilsbacher J, Cobb M, Pouyssegur J, Shaw JP, Arkinstall S. Substrate recognition domains within extracellular signal-regulated kinase mediate binding and catalytic activation of mitogen-activated protein kinase phosphatase-3. The Journal of Biological Chemistry. 275: 24613-21. PMID 10811804 DOI: 10.1074/Jbc.M001515200  0.504
2000 Chaudhary A, King WG, Mattaliano MD, Frost JA, Diaz B, Morrison DK, Cobb MH, Marshall MS, Brugge JS. Phosphatidylinositol 3-kinase regulates Raf1 through Pak phosphorylation of serine 338. Current Biology : Cb. 10: 551-4. PMID 10801448 DOI: 10.1016/S0960-9822(00)00475-9  0.405
2000 Liou J, Kiefer F, Dang A, Hashimoto A, Cobb MH, Kurosaki T, Weiss A. HPK1 is activated by lymphocyte antigen receptors and negatively regulates AP-1. Immunity. 12: 399-408. PMID 10795738 DOI: 10.1016/S1074-7613(00)80192-2  0.419
2000 Frost JA, Swantek JL, Stippec S, Yin MJ, Gaynor R, Cobb MH. Stimulation of NFkappa B activity by multiple signaling pathways requires PAK1. The Journal of Biological Chemistry. 275: 19693-9. PMID 10779525 DOI: 10.1074/jbc.M909860199  0.373
2000 Cobb MH, Goldsmith EJ. Dimerization in MAP-kinase signaling. Trends in Biochemical Sciences. 25: 7-9. PMID 10637602 DOI: 10.1016/S0968-0004(99)01508-X  0.39
1999 Karandikar M, Cobb MH. Scaffolding and protein interactions in MAP kinase modules. Cell Calcium. 26: 219-26. PMID 10643560 DOI: 10.1054/ceca.1999.0074  0.391
1999 English J, Pearson G, Wilsbacher J, Swantek J, Karandikar M, Xu S, Cobb MH. New insights into the control of MAP kinase pathways. Experimental Cell Research. 253: 255-70. PMID 10579927 DOI: 10.1006/Excr.1999.4687  0.728
1999 Xu Be, Wilsbacher JL, Collisson T, Cobb MH. The N-terminal ERK-binding site of MEK1 is required for efficient feedback phosphorylation by ERK2 in vitro and ERK activation in vivo. The Journal of Biological Chemistry. 274: 34029-35. PMID 10567369 DOI: 10.1074/jbc.274.48.34029  0.366
1999 Wang J, Frost JA, Cobb MH, Ross EM. Reciprocal signaling between heterotrimeric G proteins and the p21-stimulated protein kinase. The Journal of Biological Chemistry. 274: 31641-7. PMID 10531372 DOI: 10.1074/Jbc.274.44.31641  0.387
1999 English JM, Pearson G, Hockenberry T, Shivakumar L, White MA, Cobb MH. Contribution of the ERK5/MEK5 pathway to Ras/Raf signaling and growth control. The Journal of Biological Chemistry. 274: 31588-92. PMID 10531364 DOI: 10.1074/jbc.274.44.31588  0.758
1999 Chen Z, Hutchison M, Cobb MH. Isolation of the protein kinase TAO2 and identification of its mitogen-activated protein kinase/extracellular signal-regulated kinase kinase binding domain. The Journal of Biological Chemistry. 274: 28803-7. PMID 10497253 DOI: 10.1074/jbc.274.40.28803  0.405
1999 Christerson LB, Vanderbilt CA, Cobb MH. MEKK1 interacts with alpha-actinin and localizes to stress fibers and focal adhesions. Cell Motility and the Cytoskeleton. 43: 186-98. PMID 10401575 DOI: 10.1002/(SICI)1097-0169(1999)43:3<186::AID-CM2>3.0.CO;2-1  0.34
1999 Wilsbacher JL, Goldsmith EJ, Cobb MH. Phosphorylation of MAP kinases by MAP/ERK involves multiple regions of MAP kinases. The Journal of Biological Chemistry. 274: 16988-94. PMID 10358048 DOI: 10.1074/Jbc.274.24.16988  0.35
1999 Cobb MH. MAP kinase pathways. Progress in Biophysics and Molecular Biology. 71: 479-500. PMID 10354710 DOI: 10.1016/S0079-6107(98)00056-X  0.369
1998 Robinson MJ, Stippec SA, Goldsmith E, White MA, Cobb MH. A constitutively active and nuclear form of the MAP kinase ERK2 is sufficient for neurite outgrowth and cell transformation. Current Biology : Cb. 8: 1141-50. PMID 9799732 DOI: 10.1016/S0960-9822(07)00485-X  0.445
1998 Hutchison M, Berman KS, Cobb MH. Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades. The Journal of Biological Chemistry. 273: 28625-32. PMID 9786855 DOI: 10.1074/jbc.273.44.28625  0.429
1998 Wang Z, Canagarajah BJ, Boehm JC, Kassisà S, Cobb MH, Young PR, Abdel-Meguid S, Adams JL, Goldsmith EJ. Structural basis of inhibitor selectivity in MAP kinases. Structure (London, England : 1993). 6: 1117-28. PMID 9753691 DOI: 10.1016/S0969-2126(98)00113-0  0.372
1998 Dang A, Frost JA, Cobb MH. The MEK1 proline-rich insert is required for efficient activation of the mitogen-activated protein kinases ERK1 and ERK2 in mammalian cells. The Journal of Biological Chemistry. 273: 19909-13. PMID 9677429 DOI: 10.1074/jbc.273.31.19909  0.416
1998 Yin MJ, Christerson LB, Yamamoto Y, Kwak YT, Xu S, Mercurio F, Barbosa M, Cobb MH, Gaynor RB. HTLV-I Tax protein binds to MEKK1 to stimulate IkappaB kinase activity and NF-kappaB activation. Cell. 93: 875-84. PMID 9630230 DOI: 10.1016/S0092-8674(00)81447-6  0.354
1998 Khokhlatchev AV, Canagarajah B, Wilsbacher J, Robinson M, Atkinson M, Goldsmith E, Cobb MH. Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation. Cell. 93: 605-15. PMID 9604935 DOI: 10.1016/S0092-8674(00)81189-7  0.393
1998 English JM, Pearson G, Baer R, Cobb MH. Identification of substrates and regulators of the mitogen-activated protein kinase ERK5 using chimeric protein kinases. The Journal of Biological Chemistry. 273: 3854-60. PMID 9461566 DOI: 10.1074/jbc.273.7.3854  0.764
1997 Xu S, Cobb MH. MEKK1 binds directly to the c-Jun N-terminal kinases/stress-activated protein kinases. The Journal of Biological Chemistry. 272: 32056-60. PMID 9405400 DOI: 10.1074/jbc.272.51.32056  0.436
1997 Frost JA, Steen H, Shapiro P, Lewis T, Ahn N, Shaw PE, Cobb MH. Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins. The Embo Journal. 16: 6426-38. PMID 9351825 DOI: 10.1093/Emboj/16.21.6426  0.413
1997 Xu S, Khoo S, Dang A, Witt S, Do V, Zhen E, Schaefer EM, Cobb MH. Differential regulation of mitogen-activated protein/ERK kinase (MEK)1 and MEK2 and activation by a Ras-independent mechanism. Molecular Endocrinology (Baltimore, Md.). 11: 1618-25. PMID 9328344 DOI: 10.1210/mend.11.11.0010  0.439
1997 Canagarajah BJ, Khokhlatchev A, Cobb MH, Goldsmith EJ. Activation mechanism of the MAP kinase ERK2 by dual phosphorylation. Cell. 90: 859-69. PMID 9298898 DOI: 10.1016/S0092-8674(00)80351-7  0.335
1997 Khoo S, Cobb MH. Activation of mitogen-activating protein kinase by glucose is not required for insulin secretion. Proceedings of the National Academy of Sciences of the United States of America. 94: 5599-604. PMID 9159118 DOI: 10.1073/pnas.94.11.5599  0.392
1997 Su YC, Han J, Xu S, Cobb M, Skolnik EY. NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain. The Embo Journal. 16: 1279-90. PMID 9135144 DOI: 10.1093/emboj/16.6.1279  0.346
1997 Wang Z, Harkins PC, Ulevitch RJ, Han J, Cobb MH, Goldsmith EJ. The structure of mitogen-activated protein kinase p38 at 2.1-A resolution. Proceedings of the National Academy of Sciences of the United States of America. 94: 2327-32. PMID 9122194 DOI: 10.1073/Pnas.94.6.2327  0.338
1997 Khokhlatchev A, Xu S, English J, Wu P, Schaefer E, Cobb MH. Reconstitution of mitogen-activated protein kinase phosphorylation cascades in bacteria. Efficient synthesis of active protein kinases. The Journal of Biological Chemistry. 272: 11057-62. PMID 9110999 DOI: 10.1074/jbc.272.17.11057  0.4
1997 Robinson MJ, Cobb MH. Mitogen-activated protein kinase pathways. Current Opinion in Cell Biology. 9: 180-6. PMID 9069255 DOI: 10.1016/S0955-0674(97)80061-0  0.427
1996 Gilbreth M, Yang P, Wang D, Frost J, Polverino A, Cobb MH, Marcus S. The highly conserved skb1 gene encodes a protein that interacts with Shk1, a fission yeast Ste20/PAK homolog. Proceedings of the National Academy of Sciences of the United States of America. 93: 13802-7. PMID 8943016 DOI: 10.1073/Pnas.93.24.13802  0.363
1996 Robinson MJ, Cheng M, Khokhlatchev A, Ebert D, Ahn N, Guan KL, Stein B, Goldsmith E, Cobb MH. Contributions of the mitogen-activated protein (MAP) kinase backbone and phosphorylation loop to MEK specificity. The Journal of Biological Chemistry. 271: 29734-9. PMID 8939908 DOI: 10.1074/Jbc.271.47.29734  0.359
1996 Cobb MH, Xu S, Cheng M, Ebert D, Robbins D, Goldsmith E, Robinson M. Structural analysis of the MAP kinase ERK2 and studies of MAP kinase regulatory pathways. Advances in Pharmacology (San Diego, Calif.). 36: 49-65. PMID 8783554 DOI: 10.1016/S1054-3589(08)60576-1  0.609
1996 Frost JA, Xu S, Hutchison MR, Marcus S, Cobb MH. Actions of Rho family small G proteins and p21-activated protein kinases on mitogen-activated protein kinase family members. Molecular and Cellular Biology. 16: 3707-13. PMID 8668187 DOI: 10.1128/Mcb.16.7.3707  0.422
1996 Cheng M, Zhen E, Robinson MJ, Ebert D, Goldsmith E, Cobb MH. Characterization of a protein kinase that phosphorylates serine 189 of the mitogen-activated protein kinase homolog ERK3. The Journal of Biological Chemistry. 271: 12057-62. PMID 8662649 DOI: 10.1074/Jbc.271.20.12057  0.403
1996 Xu S, Robbins DJ, Christerson LB, English JM, Vanderbilt CA, Cobb MH. Cloning of rat MEK kinase 1 cDNA reveals an endogenous membrane-associated 195-kDa protein with a large regulatory domain. Proceedings of the National Academy of Sciences of the United States of America. 93: 5291-5. PMID 8643568 DOI: 10.1073/pnas.93.11.5291  0.528
1996 Cheng M, Boulton TG, Cobb MH. ERK3 is a constitutively nuclear protein kinase. The Journal of Biological Chemistry. 271: 8951-8. PMID 8621539 DOI: 10.1074/jbc.271.15.8951  0.414
1995 Zhai L, Graves PR, Robinson LC, Italiano M, Culbertson MR, Rowles J, Cobb MH, DePaoli-Roach AA, Roach PJ. Casein kinase I gamma subfamily. Molecular cloning, expression, and characterization of three mammalian isoforms and complementation of defects in the Saccharomyces cerevisiae YCK genes. The Journal of Biological Chemistry. 270: 12717-24. PMID 7759525 DOI: 10.1074/Jbc.270.21.12717  0.302
1995 Xu S, Robbins D, Frost J, Dang A, Lange-Carter C, Cobb MH. MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinase. Proceedings of the National Academy of Sciences of the United States of America. 92: 6808-12. PMID 7624324 DOI: 10.1073/pnas.92.15.6808  0.612
1995 Marcus S, Polverino A, Chang E, Robbins D, Cobb MH, Wigler MH. Shk1, a homolog of the Saccharomyces cerevisiae Ste20 and mammalian p65PAK protein kinases, is a component of a Ras/Cdc42 signaling module in the fission yeast Schizosaccharomyces pombe. Proceedings of the National Academy of Sciences of the United States of America. 92: 6180-4. PMID 7597098 DOI: 10.1073/Pnas.92.13.6180  0.605
1995 Polverino A, Frost J, Yang P, Hutchison M, Neiman AM, Cobb MH, Marcus S. Activation of mitogen-activated protein kinase cascades by p21-activated protein kinases in cell-free extracts of Xenopus oocytes. The Journal of Biological Chemistry. 270: 26067-70. PMID 7592806 DOI: 10.1074/Jbc.270.44.26067  0.397
1995 Zhang J, Zhang F, Ebert D, Cobb MH, Goldsmith EJ. Activity of the MAP kinase ERK2 is controlled by a flexible surface loop Structure. 3: 299-307. PMID 7540485 DOI: 10.1016/S0969-2126(01)00160-5  0.331
1995 English JM, Vanderbilt CA, Xu S, Marcus S, Cobb MH. Isolation of MEK5 and differential expression of alternatively spliced forms. The Journal of Biological Chemistry. 270: 28897-902. PMID 7499418 DOI: 10.1074/Jbc.270.48.28897  0.402
1994 Frost JA, Geppert TD, Cobb MH, Feramisco JR. A requirement for extracellular signal-regulated kinase (ERK) function in the activation of AP-1 by Ha-Ras, phorbol 12-myristate 13-acetate, and serum. Proceedings of the National Academy of Sciences of the United States of America. 91: 3844-8. PMID 8170999  0.303
1994 Zhang F, Strand A, Robbins D, Cobb MH, Goldsmith EJ. Atomic structure of the MAP kinase ERK2 at 2.3 A resolution. Nature. 367: 704-11. PMID 8107865 DOI: 10.1038/367704A0  0.579
1994 Robbins DJ, Zhen E, Cheng M, Xu S, Ebert D, Cobb MH. MAP kinases ERK1 and ERK2: pleiotropic enzymes in a ubiquitous signaling network. Advances in Cancer Research. 63: 93-116. PMID 8036991  0.532
1994 Minden A, Lin A, Smeal T, Dérijard B, Cobb M, Davis R, Karin M. c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases Molecular and Cellular Biology. 14: 6683-6688. PMID 7935387 DOI: 10.1128/mcb.14.10.6683-6688.1994  0.345
1994 Cobb MH, Xu S, Hepler JE, Hutchison M, Frost J, Robbins DJ. Regulation of the MAP kinase cascade. Cellular & Molecular Biology Research. 40: 253-6. PMID 7874203  0.605
1994 Cobb MH, Hepler JE, Cheng M, Robbins D. The mitogen-activated protein kinases, ERK1 and ERK2. Seminars in Cancer Biology. 5: 261-8. PMID 7803762  0.613
1993 Robbins DJ, Zhen E, Owaki H, Vanderbilt CA, Ebert D, Geppert TD, Cobb MH. Regulation and properties of extracellular signal-regulated protein kinases 1 and 2 in vitro. The Journal of Biological Chemistry. 268: 5097-106. PMID 8444886  0.606
1993 Zhang F, Robbins DJ, Cobb MH, Goldsmith EJ. Crystallization and preliminary X-ray studies of extracellular signal-regulated kinase-2/MAP kinase with an incorporated His-tag. Journal of Molecular Biology. 233: 550-2. PMID 8411162 DOI: 10.1006/Jmbi.1993.1532  0.588
1993 Verlhac MH, De Pennart H, Maro B, Cobb MH, Clarke HJ. MAP kinase becomes stably activated at metaphase and is associated with microtubule-organizing centers during meiotic maturation of mouse oocytes Developmental Biology. 158: 330-340. PMID 8344454 DOI: 10.1006/DBIO.1993.1192  0.319
1993 Robbins DJ, Zhen E, Cheng M, Xu S, Vanderbilt CA, Ebert D, Garcia C, Dang A, Cobb MH. Regulation and properties of extracellular signal-regulated protein kinases 1, 2, and 3. Journal of the American Society of Nephrology : Jasn. 4: 1104-10. PMID 8305637  0.623
1993 Sontag E, Fedorov S, Kamibayashi C, Robbins D, Cobb M, Mumby M. The interaction of SV40 small tumor antigen with protein phosphatase 2A stimulates the map kinase pathway and induces cell proliferation. Cell. 75: 887-97. PMID 8252625 DOI: 10.1016/0092-8674(93)90533-V  0.629
1993 Cheng JT, Cobb MH, Baer R. Phosphorylation of the TAL1 oncoprotein by the extracellular-signal-regulated protein kinase ERK1. Molecular and Cellular Biology. 13: 801-808. DOI: 10.1128/MCB.13.2.801  0.418
1992 Robbins DJ, Cobb MH. Extracellular signal-regulated kinases 2 autophosphorylates on a subset of peptides phosphorylated in intact cells in response to insulin and nerve growth factor: analysis by peptide mapping. Molecular Biology of the Cell. 3: 299-308. PMID 1627831  0.608
1992 Owaki H, Makar R, Boulton TG, Cobb MH, Geppert TD. Extracellular signal-regulated kinases in T cells: Characterization of human ERK1 and ERK2 cDNAs Biochemical and Biophysical Research Communications. 182: 1416-1422. PMID 1540184 DOI: 10.1016/0006-291X(92)91891-S  0.375
1992 Robbins DJ, Cheng M, Zhen E, Vanderbilt CA, Feig LA, Cobb MH. Evidence for a Ras-dependent extracellular signal-regulated protein kinase (ERK) cascade. Proceedings of the National Academy of Sciences of the United States of America. 89: 6924-8. PMID 1495981 DOI: 10.1073/Pnas.89.15.6924  0.545
1992 Loeb DM, Tsao H, Cobb MH, Greene LA. NGF and other growth factors induce an association between ERK1 and the NGF receptor, gp140prototrk Neuron. 9: 1053-1065. PMID 1463607 DOI: 10.1016/0896-6273(92)90065-L  0.328
1992 Funasaka Y, Boulton T, Cobb M, Yarden Y, Fan B, Lyman SD, Williams DE, Anderson DM, Zakut R, Mishima Y. c-Kit-kinase induces a cascade of protein tyrosine phosphorylation in normal human melanocytes in response to mast cell growth factor and stimulates mitogen-activated protein kinase but is down-regulated in melanomas. Molecular Biology of the Cell. 3: 197-209. PMID 1372524 DOI: 10.1091/Mbc.3.2.197  0.518
1992 Haycock JW, Ahn NG, Cobb MH, Krebs EG. ERK1 and ERK2, two microtubule-associated protein 2 kinases, mediate the phosphorylation of tyrosine hydroxylase at serine-31 in situ. Proceedings of the National Academy of Sciences of the United States of America. 89: 2365-9. PMID 1347949 DOI: 10.1073/Pnas.89.6.2365  0.396
1992 Shibuya EK, Boulton TG, Cobb MH, Ruderman JV. Activation of p42 MAP kinase and the release of oocytes from cell cycle arrest. The Embo Journal. 11: 3963-75. PMID 1327752 DOI: 10.1002/J.1460-2075.1992.Tb05490.X  0.372
1992 Ahn NG, Robbins DJ, Haycock JW, Seger R, Cobb MH, Krebs EG. Identification of an activator of the microtubule-associated protein 2 kinases ERK1 and ERK2 in PC12 cells stimulated with nerve growth factor or bradykinin. Journal of Neurochemistry. 59: 147-56. PMID 1319464 DOI: 10.1111/J.1471-4159.1992.Tb08885.X  0.609
1992 Lee RM, Cobb MH, Blackshear PJ. Evidence that extracellular signal-regulated kinases are the insulin-activated Raf-1 kinase kinases. Journal of Biological Chemistry. 267: 1088-1092. DOI: 10.1016/s0021-9258(18)48399-8  0.419
1991 Boulton TG, Nye SH, Robbins DJ, Ip NY, Radziejewska E, Morgenbesser SD, DePinho RA, Panayotatos N, Cobb MH, Yancopoulos GD. ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell. 65: 663-75. PMID 2032290 DOI: 10.1016/0092-8674(91)90098-J  0.614
1991 Boulton TG, Gregory JS, Cobb MH. Purification and properties of extracellular signal-regulated kinase 1, an insulin-stimulated microtubule-associated protein 2 kinase Biochemistry®. 30: 278-286. PMID 1846291 DOI: 10.1021/BI00215A038  0.362
1991 Cobb MH, Boulton TG, Robbins DJ. Extracellular signal-regulated kinases: ERKs in progress. Cell Regulation. 2: 965-78. PMID 1801927  0.59
1991 Seger R, Ahn NG, Boulton TG, Yancopoulos GD, Panayotatos N, Radziejewska E, Ericsson L, Bratlien RL, Cobb MH, Krebs EG. Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and threonine residues: implications for their mechanism of activation. Proceedings of the National Academy of Sciences of the United States of America. 88: 6142-6. PMID 1712480 DOI: 10.1073/Pnas.88.14.6142  0.396
1991 Cobb MH, Robbins DJ, Boulton TG. ERKs, extracellular signal-regulated MAP-2 kinases. Current Opinion in Cell Biology. 3: 1025-32. PMID 1667578 DOI: 10.1016/0955-0674(91)90124-H  0.607
1991 Boulton TG, Cobb MH. Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies Cell Regulation. 2: 357-371. PMID 1654126 DOI: 10.1091/MBC.2.5.357  0.424
1990 Boulton TG, Yancopoulos GD, Gregory JS, Slaughter C, Moomaw C, Hsu J, Cobb MH. An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control Science. 249: 64-67. PMID 2164259 DOI: 10.1126/SCIENCE.2164259  0.455
1990 Yancopoulos GD, Maisonpierre PC, Ip NY, Aldrich TH, Belluscio L, Boulton TG, Cobb MH, Squinto SP, Furth ME. Neurotrophic factors, their receptors, and the signal transduction pathways they activate. Cold Spring Harbor Symposia On Quantitative Biology. 55: 371-9. PMID 1966766 DOI: 10.1101/Sqb.1990.055.01.038  0.366
1988 Ellis L, Levitan A, Cobb MH, Ramos P. Efficient expression in insect cells of a soluble, active human insulin receptor protein-tyrosine kinase domain by use of a baculovirus vector Journal of Virology. 62: 1634-1639. PMID 2833613 DOI: 10.1128/JVI.62.5.1634-1639.1988  0.362
1986 Cobb MH, Burr JG, Linder ME, Gray TB, Gregory JS. A similar ribosomal protein S6 kinase activity is found in insulin-treated 3T3-L1 cells and chick embryo fibroblasts transformed by Rous sarcoma virus Biochemical and Biophysical Research Communications. 137: 702-708. PMID 3015127 DOI: 10.1016/0006-291X(86)91135-6  0.33
1985 Smith RM, Cobb MH, Rosen OM, Jarett L. Ultrastructural analysis of the organization and distribution of insulin receptors on the surface of 3T3-L1 adipocytes: Rapid microaggregation and migration of occupied receptors Journal of Cellular Physiology. 123: 167-179. PMID 3920228 DOI: 10.1002/Jcp.1041230204  0.519
1984 Cobb MH, Rosen OM. The insulin receptor and tyrosine protein kinase activity Bba - Reviews On Cancer. 738: 1-8. PMID 6331499 DOI: 10.1016/0304-419X(84)90016-7  0.621
1983 Rosen OM, Herrera R, Olowe Y, Petruzzelli LM, Cobb MH. Phosphorylation activates the insulin receptor tyrosine protein kinase Proceedings of the National Academy of Sciences of the United States of America. 80: 3237-3240. PMID 6574482 DOI: 10.1073/Pnas.80.11.3237  0.61
1983 Cobb MH, Rosen OM. Description of a protein kinase derived from insulin-treated 3T3-L1 cells that catalyzes the phosphorylation of ribosomal protein S6 and casein. Journal of Biological Chemistry. 258: 12472-12481. DOI: 10.1016/s0021-9258(17)44200-1  0.324
1982 Petruzzelli LM, Ganguly S, Smith CJ, Cobb MH, Rubin CS, Rosen OM. Insulin activates a tyrosine-specific protein kinase in extracts of 3T3-L1 adipocytes and human placenta. Proceedings of the National Academy of Sciences of the United States of America. 79: 6792-6. PMID 6294652 DOI: 10.1073/Pnas.79.22.6792  0.723
1981 Rosen OM, Rubin CS, Cobb MH, Smith CJ. Insulin stimulates the phosphorylation of ribosomal protein S6 in a cell-free system derived from 3T3-L1 adipocytes. The Journal of Biological Chemistry. 256: 3630-3. PMID 7012140  0.678
1980 Cobb MH, Heagy W, Danner J, Lenhoff HM, Marshall GR. Effect of glutathione on cyclic nucleotide levels in hydra attenuata Comparative Biochemistry and Physiology. Part C, Comparative. 65: 111-115. DOI: 10.1016/0306-4492(80)90030-1  0.434
1978 Danner J, Cobb MH, Heagy W, Lenhoff HM, Marshall GR. Interaction of glutathione analogues with Hydra attenuata gamma-glutamyltransferase. The Biochemical Journal. 175: 547-53. PMID 33656 DOI: 10.1042/Bj1750547  0.403
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