Alex Whitworth - Publications

University of Sheffield, Sheffield, England, United Kingdom 

32 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Malik BR, Godena VK, Whitworth AJ. VPS35 pathogenic mutations confer no dominant toxicity but partial loss of function in Drosophila and genetically interact with parkin. Human Molecular Genetics. 24: 6106-17. PMID 26251041 DOI: 10.1093/hmg/ddv322  1
2015 López Del Amo V, Seco-Cervera M, García-Giménez JL, Whitworth AJ, Pallardó FV, Galindo MI. Mitochondrial defects and neuromuscular degeneration caused by altered expression of Drosophila Gdap1: implications for the Charcot-Marie-Tooth neuropathy. Human Molecular Genetics. 24: 21-36. PMID 25122658 DOI: 10.1093/hmg/ddu416  1
2014 Pogson JH, Ivatt RM, Sanchez-Martinez A, Tufi R, Wilson E, Mortiboys H, Whitworth AJ. The complex I subunit NDUFA10 selectively rescues Drosophila pink1 mutants through a mechanism independent of mitophagy. Plos Genetics. 10: e1004815. PMID 25412178 DOI: 10.1371/journal.pgen.1004815  1
2014 Godena VK, Brookes-Hocking N, Moller A, Shaw G, Oswald M, Sancho RM, Miller CC, Whitworth AJ, De Vos KJ. Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations. Nature Communications. 5: 5245. PMID 25316291 DOI: 10.1038/ncomms6245  1
2014 Jansen RL, Brogan B, Whitworth AJ, Okello EJ. Effects of five Ayurvedic herbs on locomotor behaviour in a Drosophila melanogaster Parkinson's disease model. Phytotherapy Research : Ptr. 28: 1789-95. PMID 25091506 DOI: 10.1002/ptr.5199  1
2014 Ivatt RM, Whitworth AJ. SREBF1 links lipogenesis to mitophagy and sporadic Parkinson disease. Autophagy. 10: 1476-7. PMID 24991824 DOI: 10.4161/auto.29642  1
2014 Ivatt RM, Sanchez-Martinez A, Godena VK, Brown S, Ziviani E, Whitworth AJ. Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy. Proceedings of the National Academy of Sciences of the United States of America. 111: 8494-9. PMID 24912190 DOI: 10.1073/pnas.1321207111  1
2014 Ivatt RM, Whitworth AJ. The many faces of mitophagy. Embo Reports. 15: 5-6. PMID 24398127 DOI: 10.1002/embr.201338224  1
2013 Burchell VS, Nelson DE, Sanchez-Martinez A, Delgado-Camprubi M, Ivatt RM, Pogson JH, Randle SJ, Wray S, Lewis PA, Houlden H, Abramov AY, Hardy J, Wood NW, Whitworth AJ, Laman H, et al. The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy. Nature Neuroscience. 16: 1257-65. PMID 23933751 DOI: 10.1038/nn.3489  1
2013 Zhang L, Karsten P, Hamm S, Pogson JH, Müller-Rischart AK, Exner N, Haass C, Whitworth AJ, Winklhofer KF, Schulz JB, Voigt A. TRAP1 rescues PINK1 loss-of-function phenotypes. Human Molecular Genetics. 22: 2829-41. PMID 23525905 DOI: 10.1093/hmg/ddt132  1
2012 Sanchez-Martinez A, Calleja M, Peralta S, Matsushima Y, Hernandez-Sierra R, Whitworth AJ, Kaguni LS, Garesse R. Modeling pathogenic mutations of human twinkle in Drosophila suggests an apoptosis role in response to mitochondrial defects. Plos One. 7: e43954. PMID 22952820 DOI: 10.1371/journal.pone.0043954  1
2011 Woodroof HI, Pogson JH, Begley M, Cantley LC, Deak M, Campbell DG, van Aalten DM, Whitworth AJ, Alessi DR, Muqit MM. Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations. Open Biology. 1: 110012. PMID 22645651 DOI: 10.1098/rsob.110012  1
2011 Pogson JH, Ivatt RM, Whitworth AJ. Molecular mechanisms of PINK1-related neurodegeneration. Current Neurology and Neuroscience Reports. 11: 283-90. PMID 21331528 DOI: 10.1007/s11910-011-0187-x  1
2011 Whitworth AJ. Drosophila models of Parkinson's disease. Advances in Genetics. 73: 1-50. PMID 21310293 DOI: 10.1016/B978-0-12-380860-8.00001-X  1
2011 Deas E, Plun-Favreau H, Gandhi S, Desmond H, Kjaer S, Loh SH, Renton AE, Harvey RJ, Whitworth AJ, Martins LM, Abramov AY, Wood NW. PINK1 cleavage at position A103 by the mitochondrial protease PARL. Human Molecular Genetics. 20: 867-79. PMID 21138942 DOI: 10.1093/hmg/ddq526  1
2010 Ziviani E, Whitworth AJ. How could Parkin-mediated ubiquitination of mitofusin promote mitophagy? Autophagy. 6: 660-2. PMID 20484985 DOI: 10.4161/auto.6.5.12242  1
2010 Ziviani E, Tao RN, Whitworth AJ. Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin. Proceedings of the National Academy of Sciences of the United States of America. 107: 5018-23. PMID 20194754 DOI: 10.1073/pnas.0913485107  1
2010 Kieper N, Holmström KM, Ciceri D, Fiesel FC, Wolburg H, Ziviani E, Whitworth AJ, Martins LM, Kahle PJ, Krüger R. Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1. Experimental Cell Research. 316: 1213-24. PMID 20064504 DOI: 10.1016/j.yexcr.2010.01.005  1
2009 Whitworth AJ, Pallanck LJ. The PINK1/Parkin pathway: a mitochondrial quality control system? Journal of Bioenergetics and Biomembranes. 41: 499-503. PMID 19967438 DOI: 10.1007/s10863-009-9253-3  1
2009 Tain LS, Whitworth AJ. Translating translation: regulated protein translation as a biomedical intervention. Fly. 3: 278-80. PMID 19875944 DOI: 10.4161/fly.10309  1
2009 Tain LS, Mortiboys H, Tao RN, Ziviani E, Bandmann O, Whitworth AJ. Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss. Nature Neuroscience. 12: 1129-35. PMID 19684592 DOI: 10.1038/nn.2372  1
2009 Tain LS, Chowdhury RB, Tao RN, Plun-Favreau H, Moisoi N, Martins LM, Downward J, Whitworth AJ, Tapon N. Drosophila HtrA2 is dispensable for apoptosis but acts downstream of PINK1 independently from Parkin. Cell Death and Differentiation. 16: 1118-25. PMID 19282869 DOI: 10.1038/cdd.2009.23  1
2008 Whitworth AJ, Lee JR, Ho VM, Flick R, Chowdhury R, McQuibban GA. Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin. Disease Models & Mechanisms. 1: 168-74; discussion 1. PMID 19048081 DOI: 10.1242/dmm.000109  1
2008 Whitworth AJ, Pallanck LJ. Genetic models of Parkinson's disease: mechanisms and therapies. Seb Experimental Biology Series. 60: 93-113. PMID 18309789  1
2008 Poole AC, Thomas RE, Andrews LA, McBride HM, Whitworth AJ, Pallanck LJ. The PINK1/Parkin pathway regulates mitochondrial morphology. Proceedings of the National Academy of Sciences of the United States of America. 105: 1638-43. PMID 18230723 DOI: 10.1073/pnas.0709336105  1
2006 Whitworth AJ, Wes PD, Pallanck LJ. Drosophila models pioneer a new approach to drug discovery for Parkinson's disease. Drug Discovery Today. 11: 119-26. PMID 16533709 DOI: 10.1016/S1359-6446(05)03693-7  1
2005 Meulener M, Whitworth AJ, Armstrong-Gold CE, Rizzu P, Heutink P, Wes PD, Pallanck LJ, Bonini NM. Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease. Current Biology : Cb. 15: 1572-7. PMID 16139213 DOI: 10.1016/j.cub.2005.07.064  1
2005 Whitworth AJ, Theodore DA, Greene JC, Benes H, Wes PD, Pallanck LJ. Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 102: 8024-9. PMID 15911761 DOI: 10.1073/pnas.0501078102  1
2005 Jackson SM, Whitworth AJ, Greene JC, Libby RT, Baccam SL, Pallanck LJ, La Spada AR. A SCA7 CAG/CTG repeat expansion is stable in Drosophila melanogaster despite modulation of genomic context and gene dosage. Gene. 347: 35-41. PMID 15715978 DOI: 10.1016/j.gene.2004.12.008  1
2005 Greene JC, Whitworth AJ, Andrews LA, Parker TJ, Pallanck LJ. Genetic and genomic studies of Drosophila parkin mutants implicate oxidative stress and innate immune responses in pathogenesis. Human Molecular Genetics. 14: 799-811. PMID 15689351 DOI: 10.1093/hmg/ddi074  1
2003 Greene JC, Whitworth AJ, Kuo I, Andrews LA, Feany MB, Pallanck LJ. Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants. Proceedings of the National Academy of Sciences of the United States of America. 100: 4078-83. PMID 12642658 DOI: 10.1073/pnas.0737556100  1
2003 Whitworth AJ, Russell S. Temporally dynamic response to Wingless directs the sequential elaboration of the proximodistal axis of the Drosophila wing. Developmental Biology. 254: 277-88. PMID 12591247 DOI: 10.1016/S0012-1606(02)00036-2  1
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