J. Paul Taylor - Publications

St Jude Children's Research Hospital, New York, NY, United States 

97 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Lee AK, Klein J, Fon Tacer K, Lord T, Oatley MJ, Oatley JM, Porter SN, Pruett-Miller SM, Tikhonova EB, Karamyshev AL, Wang YD, Yang P, Korff A, Kim HJ, Taylor JP, et al. Translational Repression of G3BP in Cancer and Germ Cells Suppresses Stress Granules and Enhances Stress Tolerance. Molecular Cell. PMID 32692974 DOI: 10.1016/J.Molcel.2020.06.037  0.4
2020 Yang P, Mathieu C, Kolaitis RM, Zhang P, Messing J, Yurtsever U, Yang Z, Wu J, Li Y, Pan Q, Yu J, Martin EW, Mittag T, Kim HJ, Taylor JP. G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules. Cell. 181: 325-345.e28. PMID 32302571 DOI: 10.1016/J.Cell.2020.03.046  0.4
2020 Batlle C, Yang P, Coughlin M, Messing J, Pesarrodona M, Szulc E, Salvatella X, Kim HJ, Taylor JP, Ventura S. hnRNPDL Phase Separation Is Regulated by Alternative Splicing and Disease-Causing Mutations Accelerate Its Aggregation. Cell Reports. 30: 1117-1128.e5. PMID 31995753 DOI: 10.1016/J.Celrep.2019.12.080  0.4
2019 White MR, Mitrea DM, Zhang P, Stanley CB, Cassidy DE, Nourse A, Phillips AH, Tolbert M, Taylor JP, Kriwacki RW. C9orf72 Poly(PR) Dipeptide Repeats Disturb Biomolecular Phase Separation and Disrupt Nucleolar Function. Molecular Cell. PMID 30981631 DOI: 10.1016/J.Molcel.2019.03.019  0.4
2019 Wang B, Maxwell BA, Joo JH, Gwon Y, Messing J, Mishra A, Shaw TI, Ward AL, Quan H, Sakurada SM, Pruett-Miller SM, Bertorini T, Vogel P, Kim HJ, Peng J, ... Taylor JP, et al. ULK1 and ULK2 Regulate Stress Granule Disassembly Through Phosphorylation and Activation of VCP/p97. Molecular Cell. PMID 30979586 DOI: 10.1016/J.Molcel.2019.03.027  0.4
2019 Zhang P, Fan B, Yang P, Temirov J, Messing J, Kim HJ, Taylor JP. Chronic optogenetic induction of stress granules is cytotoxic and reveals the evolution of ALS-FTD pathology. Elife. 8. PMID 30893049 DOI: 10.7554/Elife.39578  0.4
2019 Nedelsky NB, Taylor JP. Bridging biophysics and neurology: aberrant phase transitions in neurodegenerative disease. Nature Reviews. Neurology. PMID 30890779 DOI: 10.1038/S41582-019-0157-5  0.92
2019 Zhang P, Fan B, Yang P, Temirov J, Messing J, Kim HJ, Taylor JP. Author response: Chronic optogenetic induction of stress granules is cytotoxic and reveals the evolution of ALS-FTD pathology Elife. DOI: 10.7554/Elife.39578.022  0.4
2018 Pajtler KW, Wen J, Sill M, Lin T, Orisme W, Tang B, Hübner JM, Ramaswamy V, Jia S, Dalton JD, Haupfear K, Rogers HA, Punchihewa C, Lee R, Easton J, ... ... Taylor JP, et al. Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas. Acta Neuropathologica. PMID 29909548 DOI: 10.1007/S00401-018-1877-0  0.4
2018 Purice MD, Taylor JP. Linking hnRNP Function to ALS and FTD Pathology. Frontiers in Neuroscience. 12: 326. PMID 29867335 DOI: 10.3389/Fnins.2018.00326  0.68
2018 Guo L, Kim HJ, Wang H, Monaghan J, Freyermuth F, Sung JC, O'Donovan K, Fare CM, Diaz Z, Singh N, Zhang ZC, Coughlin M, Sweeny EA, DeSantis ME, Jackrel ME, ... ... Taylor JP, et al. Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains. Cell. 173: 677-692.e20. PMID 29677512 DOI: 10.1016/J.Cell.2018.03.002  0.68
2018 Zhang K, Daigle JG, Cunningham KM, Coyne AN, Ruan K, Grima JC, Bowen KE, Wadhwa H, Yang P, Rigo F, Taylor JP, Gitler AD, Rothstein JD, Lloyd TE. Stress Granule Assembly Disrupts Nucleocytoplasmic Transport. Cell. PMID 29628143 DOI: 10.1016/J.Cell.2018.03.025  0.4
2018 Nicolas A, Kenna KP, Renton AE, Ticozzi N, Faghri F, Chia R, Dominov JA, Kenna BJ, Nalls MA, Keagle P, Rivera AM, van Rheenen W, Murphy NA, van Vugt JJFA, Geiger JT, ... ... Taylor JP, et al. Genome-wide Analyses Identify KIF5A as a Novel ALS Gene. Neuron. 97: 1268-1283.e6. PMID 29566793 DOI: 10.1016/J.Neuron.2018.02.027  0.4
2018 Dao TP, Kolaitis RM, Kim HJ, O'Donovan K, Martyniak B, Colicino E, Hehnly H, Taylor JP, Castañeda CA. Ubiquitin Modulates Liquid-Liquid Phase Separation of UBQLN2 via Disruption of Multivalent Interactions. Molecular Cell. PMID 29526694 DOI: 10.1016/J.Molcel.2018.02.004  0.4
2018 Badders NM, Korff A, Miranda HC, Vuppala PK, Smith RB, Winborn BJ, Quemin ER, Sopher BL, Dearman J, Messing J, Kim NC, Moore J, Freibaum BD, Kanagaraj AP, Fan B, ... ... Taylor JP, et al. Selective modulation of the androgen receptor AF2 domain rescues degeneration in spinal bulbar muscular atrophy. Nature Medicine. PMID 29505030 DOI: 10.1038/Nm.4500  0.72
2018 Wen J, Hübner J, Orisme W, Wu G, Tang B, Jia S, Easton J, Haupfear K, Freibaum BD, Kim HJ, High A, Peng J, Tatevossian RG, Taylor JP, Pfister SM, et al. Abstract PR08: Overexpression and mutations of CXorf67 in “infant-type” posterior fossa type-A ependymomas Cancer Research. 78. DOI: 10.1158/1538-7445.Pedca17-Pr08  0.4
2017 Kim HJ, Taylor JP. Lost in Transportation: Nucleocytoplasmic Transport Defects in ALS and Other Neurodegenerative Diseases. Neuron. 96: 285-297. PMID 29024655 DOI: 10.1016/J.Neuron.2017.07.029  0.76
2017 Mackenzie IR, Nicholson AM, Sarkar M, Messing J, Purice MD, Pottier C, Annu K, Baker M, Perkerson RB, Kurti A, Matchett BJ, Mittag T, Temirov J, Hsiung GR, Krieger C, ... ... Taylor JP, et al. TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics. Neuron. 95: 808-816.e9. PMID 28817800 DOI: 10.1016/J.Neuron.2017.07.025  0.68
2017 Becker LA, Huang B, Bieri G, Ma R, Knowles DA, Jafar-Nejad P, Messing J, Kim HJ, Soriano A, Auburger G, Pulst SM, Taylor JP, Rigo F, Gitler AD. Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice. Nature. PMID 28405022 DOI: 10.1038/Nature22038  0.4
2016 Lanman TA, Bakar D, Badders NM, Burke A, Kokkinis A, Shrader JA, Joe GO, Schindler AB, Bott LC, Harmison GG, Taylor JP, Fischbeck KH, Grunseich C. Sexual Reassignment Fails to Prevent Kennedy's Disease. Journal of Neuromuscular Diseases. 3: 121-125. PMID 27854206 DOI: 10.3233/Jnd-150128  0.56
2016 Martinez FJ, Pratt GA, Van Nostrand EL, Batra R, Huelga SC, Kapeli K, Freese P, Chun SJ, Ling K, Gelboin-Burkhart C, Fijany L, Wang HC, Nussbacher JK, Broski SM, Kim HJ, ... ... Taylor JP, et al. Protein-RNA Networks Regulated by Normal and ALS-Associated Mutant HNRNPA2B1 in the Nervous System. Neuron. PMID 27773581 DOI: 10.1016/J.Neuron.2016.09.050  0.4
2016 Lee KH, Zhang P, Kim HJ, Mitrea DM, Sarkar M, Freibaum BD, Cika J, Coughlin M, Messing J, Molliex A, Maxwell BA, Kim NC, Temirov J, Moore J, Kolaitis RM, ... ... Taylor JP, et al. C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles. Cell. 167: 774-788.e17. PMID 27768896 DOI: 10.1016/J.Cell.2016.10.002  0.4
2016 Valentin-Vega YA, Wang YD, Parker M, Patmore DM, Kanagaraj A, Moore J, Rusch M, Finkelstein D, Ellison DW, Gilbertson RJ, Zhang J, Kim HJ, Taylor JP. Cancer-associated DDX3X mutations drive stress granule assembly and impair global translation. Scientific Reports. 6: 25996. PMID 27180681 DOI: 10.1038/Srep25996  0.92
2016 Bott LC, Badders NM, Chen KL, Harmison GG, Bautista E, Shih CC, Katsuno M, Sobue G, Taylor JP, Dantuma NP, Fischbeck KH, Rinaldi C. A small-molecule Nrf1 and Nrf2 activator mitigates polyglutamine toxicity in spinal and bulbar muscular atrophy. Human Molecular Genetics. PMID 26962150 DOI: 10.1093/Hmg/Ddw073  0.56
2016 Li S, Freibaum BD, Zhang P, Kim NC, Kolaitis RM, Molliex A, Kanagaraj AP, Yabe I, Tanino M, Tanaka S, Sasaki H, Ross ED, Taylor JP, Kim HJ. Genetic Interaction of hnRNPA2B1 and DNAJB6 in a Drosophila Model of Multisystem Proteinopathy. Human Molecular Genetics. PMID 26744327 DOI: 10.1093/Hmg/Ddv627  0.92
2015 Molliex A, Temirov J, Lee J, Coughlin M, Kanagaraj AP, Kim HJ, Mittag T, Taylor JP. Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization. Cell. 163: 123-33. PMID 26406374 DOI: 10.1016/J.Cell.2015.09.015  0.92
2015 Freibaum BD, Lu Y, Lopez-Gonzalez R, Kim NC, Almeida S, Lee KH, Badders N, Valentine M, Miller BL, Wong PC, Petrucelli L, Kim HJ, Gao FB, Taylor JP. GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport. Nature. 525: 129-33. PMID 26308899 DOI: 10.1038/Nature14974  0.92
2015 Taylor JP. Multisystem proteinopathy: Intersecting genetics in muscle, bone, and brain degeneration. Neurology. 85: 658-60. PMID 26208960 DOI: 10.1212/Wnl.0000000000001862  0.92
2015 Oh SY, He F, Krans A, Frazer M, Taylor JP, Paulson HL, Todd PK. RAN translation at CGG repeats induces ubiquitin proteasome system impairment in models of fragile X-associated tremor ataxia syndrome. Human Molecular Genetics. 24: 4317-26. PMID 25954027 DOI: 10.1093/Hmg/Ddv165  0.72
2015 Norris KL, Hao R, Chen LF, Lai CH, Kapur M, Shaughnessy PJ, Chou D, Yan J, Taylor JP, Engelender S, West AE, Lim KL, Yao TP. Convergence of Parkin, PINK1, and α-Synuclein on Stress-induced Mitochondrial Morphological Remodeling. The Journal of Biological Chemistry. 290: 13862-74. PMID 25861987 DOI: 10.1074/jbc.M114.634063  0.92
2015 Sanhueza M, Chai A, Smith C, McCray BA, Simpson TI, Taylor JP, Pennetta G. Network analyses reveal novel aspects of ALS pathogenesis. Plos Genetics. 11: e1005107. PMID 25826266 DOI: 10.1371/Journal.Pgen.1005107  0.92
2015 Scoto M, Rossor AM, Harms MB, Cirak S, Calissano M, Robb S, Manzur AY, Martínez Arroyo A, Rodriguez Sanz A, Mansour S, Fallon P, Hadjikoumi I, Klein A, Yang M, De Visser M, ... ... Taylor JP, et al. Novel mutations expand the clinical spectrum of DYNC1H1-associated spinal muscular atrophy. Neurology. 84: 668-79. PMID 25609763 DOI: 10.1212/Wnl.0000000000001269  0.92
2015 Scaramuzzino C, Casci I, Parodi S, Lievens PM, Polanco MJ, Milioto C, Chivet M, Monaghan J, Mishra A, Badders N, Aggarwal T, Grunseich C, Sambataro F, Basso M, Fackelmayer FO, ... Taylor JP, et al. Protein arginine methyltransferase 6 enhances polyglutamine-expanded androgen receptor function and toxicity in spinal and bulbar muscular atrophy. Neuron. 85: 88-100. PMID 25569348 DOI: 10.1016/J.Neuron.2014.12.031  0.92
2015 Oskarsson B, Wheelock V, Benatar M, Taylor JP, Joyce N, Chesak D, Jin LW. A case of familial ALS due to multi-system proteinopathy 1 and Huntington disease. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 16: 124-6. PMID 25205077 DOI: 10.3109/21678421.2014.952238  0.92
2014 Lee JY, Kapur M, Li M, Choi MC, Choi S, Kim HJ, Kim I, Lee E, Taylor JP, Yao TP. MFN1 deacetylation activates adaptive mitochondrial fusion and protects metabolically challenged mitochondria. Journal of Cell Science. 127: 4954-63. PMID 25271058 DOI: 10.1242/jcs.157321  0.92
2014 Gao FB, Taylor JP. RNA metabolism in neurological disease. Brain Research. 1584: 1-2. PMID 25248315 DOI: 10.1016/J.Brainres.2014.09.011  0.92
2014 He F, Krans A, Freibaum BD, Taylor JP, Todd PK. TDP-43 suppresses CGG repeat-induced neurotoxicity through interactions with HnRNP A2/B1. Human Molecular Genetics. 23: 5036-51. PMID 24920338 DOI: 10.1093/Hmg/Ddu216  0.72
2014 Pinkus JL, Amato AA, Taylor JP, Greenberg SA. Abnormal distribution of heterogeneous nuclear ribonucleoproteins in sporadic inclusion body myositis. Neuromuscular Disorders : Nmd. 24: 611-6. PMID 24857366 DOI: 10.1016/J.Nmd.2014.04.012  0.92
2014 Johnson JO, Pioro EP, Boehringer A, Chia R, Feit H, Renton AE, Pliner HA, Abramzon Y, Marangi G, Winborn BJ, Gibbs JR, Nalls MA, Morgan S, Shoai M, Hardy J, ... ... Taylor JP, et al. Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis. Nature Neuroscience. 17: 664-6. PMID 24686783 DOI: 10.1038/Nn.3688  0.92
2014 Seelen M, Visser AE, Overste DJ, Kim HJ, Palud A, Wong TH, van Swieten JC, Scheltens P, Voermans NC, Baas F, de Jong JM, van der Kooi AJ, de Visser M, Veldink JH, Taylor JP, et al. No mutations in hnRNPA1 and hnRNPA2B1 in Dutch patients with amyotrophic lateral sclerosis, frontotemporal dementia, and inclusion body myopathy. Neurobiology of Aging. 35: 1956.e9-1956.e11. PMID 24612671 DOI: 10.1016/J.Neurobiolaging.2014.01.152  0.4
2014 Taylor JP. Neurodegenerative diseases: G-quadruplex poses quadruple threat. Nature. 507: 175-7. PMID 24598546 DOI: 10.1038/Nature13067  0.92
2014 Alami NH, Smith RB, Carrasco MA, Williams LA, Winborn CS, Han SS, Kiskinis E, Winborn B, Freibaum BD, Kanagaraj A, Clare AJ, Badders NM, Bilican B, Chaum E, Chandran S, ... ... Taylor JP, et al. Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations. Neuron. 81: 536-43. PMID 24507191 DOI: 10.1016/J.Neuron.2013.12.018  0.92
2013 Ramaswami M, Taylor JP, Parker R. Altered ribostasis: RNA-protein granules in degenerative disorders. Cell. 154: 727-36. PMID 23953108 DOI: 10.1016/J.Cell.2013.07.038  0.92
2013 Buchan JR, Kolaitis RM, Taylor JP, Parker R. Eukaryotic stress granules are cleared by autophagy and Cdc48/VCP function. Cell. 153: 1461-74. PMID 23791177 DOI: 10.1016/J.Cell.2013.05.037  0.92
2013 Benatar M, Wuu J, Fernandez C, Weihl CC, Katzen H, Steele J, Oskarsson B, Taylor JP. Motor neuron involvement in multisystem proteinopathy: implications for ALS. Neurology. 80: 1874-80. PMID 23635965 DOI: 10.1212/Wnl.0B013E3182929Fc3  0.92
2013 Todd PK, Oh SY, Krans A, He F, Sellier C, Frazer M, Renoux AJ, Chen KC, Scaglione KM, Basrur V, Elenitoba-Johnson K, Vonsattel JP, Louis ED, Sutton MA, Taylor JP, et al. CGG repeat-associated translation mediates neurodegeneration in fragile X tremor ataxia syndrome. Neuron. 78: 440-55. PMID 23602499 DOI: 10.1016/J.Neuron.2013.03.026  0.56
2013 Kim NC, Tresse E, Kolaitis RM, Molliex A, Thomas RE, Alami NH, Wang B, Joshi A, Smith RB, Ritson GP, Winborn BJ, Moore J, Lee JY, Yao TP, Pallanck L, ... ... Taylor JP, et al. VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations. Neuron. 78: 65-80. PMID 23498974 DOI: 10.1016/J.Neuron.2013.02.029  0.92
2013 Taylor JP. Neuroscience. RNA that gets RAN in neurodegeneration. Science (New York, N.Y.). 339: 1282-3. PMID 23493702 DOI: 10.1126/Science.1236450  0.92
2013 Kim HJ, Kim NC, Wang YD, Scarborough EA, Moore J, Diaz Z, MacLea KS, Freibaum B, Li S, Molliex A, Kanagaraj AP, Carter R, Boylan KB, Wojtas AM, Rademakers R, ... ... Taylor JP, et al. Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS. Nature. 495: 467-73. PMID 23455423 DOI: 10.1038/Nature11922  0.92
2012 Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, ... ... Taylor JP, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 8: 445-544. PMID 22966490 DOI: 10.4161/Auto.19496  0.68
2012 Park YN, Zhao X, Norton M, Taylor JP, Eisenberg E, Greene LE. Huntingtin fragments and SOD1 mutants form soluble oligomers in the cell. Plos One. 7: e40329. PMID 22768276 DOI: 10.1371/Journal.Pone.0040329  0.92
2012 Gao FB, Taylor JP. RNA-binding proteins in neurological disease. Brain Research. 1462: 1-2. PMID 22682432 DOI: 10.1016/j.brainres.2012.05.038  0.92
2012 Usenovic M, Tresse E, Mazzulli JR, Taylor JP, Krainc D. Deficiency of ATP13A2 leads to lysosomal dysfunction, α-synuclein accumulation, and neurotoxicity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 4240-6. PMID 22442086 DOI: 10.1523/Jneurosci.5575-11.2012  0.92
2012 Messing A, Li R, Naidu S, Taylor JP, Silverman L, Flint D, van der Knaap MS, Brenner M. Archetypal and new families with Alexander disease and novel mutations in GFAP. Archives of Neurology. 69: 208-14. PMID 21987397 DOI: 10.1001/Archneurol.2011.1181  0.92
2012 Majounie E, Traynor BJ, Chiò A, Restagno G, Mandrioli J, Benatar M, Taylor JP, Singleton AB. Mutational analysis of the VCP gene in Parkinson's disease. Neurobiology of Aging. 33: 209.e1-2. PMID 21920633 DOI: 10.1016/J.Neurobiolaging.2011.07.011  0.92
2011 Mammen AL, Mahoney JA, St Germain A, Badders N, Taylor JP, Rosen A, Spinette S. A novel conserved isoform of the ubiquitin ligase UFD2a/UBE4B is expressed exclusively in mature striated muscle cells. Plos One. 6: e28861. PMID 22174917 DOI: 10.1371/Journal.Pone.0028861  0.92
2011 Smith R, Taylor JP. Dissection and imaging of active zones in the Drosophila neuromuscular junction. Journal of Visualized Experiments : Jove. PMID 21559003 DOI: 10.3791/2676  0.92
2011 Lanson NA, Maltare A, King H, Smith R, Kim JH, Taylor JP, Lloyd TE, Pandey UB. A Drosophila model of FUS-related neurodegeneration reveals genetic interaction between FUS and TDP-43. Human Molecular Genetics. 20: 2510-23. PMID 21487023 DOI: 10.1093/Hmg/Ddr150  0.92
2011 Badders NM, Taylor JP. Drosophila and Mouse Models of Hereditary Myopathy Caused by Mutations in VCP/p97 Muscle Aging, Inclusion-Body Myositis and Myopathies. 230-239. DOI: 10.1002/9781444398311.ch16  0.92
2010 Todd PK, Oh SY, Krans A, Pandey UB, Di Prospero NA, Min KT, Taylor JP, Paulson HL. Histone deacetylases suppress CGG repeat-induced neurodegeneration via transcriptional silencing in models of fragile X tremor ataxia syndrome. Plos Genetics. 6: e1001240. PMID 21170301 DOI: 10.1371/Journal.Pgen.1001240  0.92
2010 Johnson JO, Mandrioli J, Benatar M, Abramzon Y, Van Deerlin VM, Trojanowski JQ, Gibbs JR, Brunetti M, Gronka S, Wuu J, Ding J, McCluskey L, Martinez-Lage M, Falcone D, Hernandez DG, ... ... Taylor JP, et al. Exome sequencing reveals VCP mutations as a cause of familial ALS. Neuron. 68: 857-64. PMID 21145000 DOI: 10.1016/J.Neuron.2010.11.036  0.92
2010 Nedelsky NB, Pennuto M, Smith RB, Palazzolo I, Moore J, Nie Z, Neale G, Taylor JP. Native functions of the androgen receptor are essential to pathogenesis in a Drosophila model of spinobulbar muscular atrophy. Neuron. 67: 936-52. PMID 20869592 DOI: 10.1016/J.Neuron.2010.08.034  0.92
2010 Ritson GP, Custer SK, Freibaum BD, Guinto JB, Geffel D, Moore J, Tang W, Winton MJ, Neumann M, Trojanowski JQ, Lee VM, Forman MS, Taylor JP. TDP-43 mediates degeneration in a novel Drosophila model of disease caused by mutations in VCP/p97. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 7729-39. PMID 20519548 DOI: 10.1523/Jneurosci.5894-09.2010  0.92
2010 Lee JY, Nagano Y, Taylor JP, Lim KL, Yao TP. Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy. The Journal of Cell Biology. 189: 671-9. PMID 20457763 DOI: 10.1083/Jcb.201001039  0.92
2010 Palazzolo I, Nedelsky NB, Askew CE, Harmison GG, Kasantsev AG, Taylor JP, Fischbeck KH, Pennuto M. B2 attenuates polyglutamine-expanded androgen receptor toxicity in cell and fly models of spinal and bulbar muscular atrophy. Journal of Neuroscience Research. 88: 2207-16. PMID 20336775 DOI: 10.1002/Jnr.22389  0.92
2010 Lloyd TE, Taylor JP. Flightless flies: Drosophila models of neuromuscular disease. Annals of the New York Academy of Sciences. 1184: e1-20. PMID 20329357 DOI: 10.1111/J.1749-6632.2010.05432.X  0.92
2010 La Spada AR, Taylor JP. Repeat expansion disease: progress and puzzles in disease pathogenesis. Nature Reviews. Genetics. 11: 247-58. PMID 20177426 DOI: 10.1038/Nrg2748  0.92
2010 Custer SK, Neumann M, Lu H, Wright AC, Taylor JP. Transgenic mice expressing mutant forms VCP/p97 recapitulate the full spectrum of IBMPFD including degeneration in muscle, brain and bone. Human Molecular Genetics. 19: 1741-55. PMID 20147319 DOI: 10.1093/Hmg/Ddq050  0.92
2010 Tresse E, Salomons FA, Vesa J, Bott LC, Kimonis V, Yao TP, Dantuma NP, Taylor JP. VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD. Autophagy. 6: 217-27. PMID 20104022 DOI: 10.4161/Auto.6.2.11014  0.92
2010 Batlevi Y, Martin DN, Pandey UB, Simon CR, Powers CM, Taylor JP, Baehrecke EH. Dynein light chain 1 is required for autophagy, protein clearance, and cell death in Drosophila. Proceedings of the National Academy of Sciences of the United States of America. 107: 742-7. PMID 20080745 DOI: 10.1073/Pnas.0907967107  0.92
2010 Lee JY, Koga H, Kawaguchi Y, Tang W, Wong E, Gao YS, Pandey UB, Kaushik S, Tresse E, Lu J, Taylor JP, Cuervo AM, Yao TP. HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy. The Embo Journal. 29: 969-80. PMID 20075865 DOI: 10.1038/Emboj.2009.405  0.92
2010 McCray BA, Skordalakes E, Taylor JP. Disease mutations in Rab7 result in unregulated nucleotide exchange and inappropriate activation. Human Molecular Genetics. 19: 1033-47. PMID 20028791 DOI: 10.1093/Hmg/Ddp567  0.92
2010 Freibaum BD, Chitta RK, High AA, Taylor JP. Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery. Journal of Proteome Research. 9: 1104-20. PMID 20020773 DOI: 10.1021/Pr901076Y  0.92
2009 Palazzolo I, Stack C, Kong L, Musaro A, Adachi H, Katsuno M, Sobue G, Taylor JP, Sumner CJ, Fischbeck KH, Pennuto M. Overexpression of IGF-1 in muscle attenuates disease in a mouse model of spinal and bulbar muscular atrophy. Neuron. 63: 316-28. PMID 19679072 DOI: 10.1016/J.Neuron.2009.07.019  0.92
2009 Mojsilovic-Petrovic J, Nedelsky N, Boccitto M, Mano I, Georgiades SN, Zhou W, Liu Y, Neve RL, Taylor JP, Driscoll M, Clardy J, Merry D, Kalb RG. FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neuron diseases. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 8236-47. PMID 19553463 DOI: 10.1523/Jneurosci.1805-09.2009  0.92
2009 Salajegheh M, Pinkus JL, Taylor JP, Amato AA, Nazareno R, Baloh RH, Greenberg SA. Sarcoplasmic redistribution of nuclear TDP-43 in inclusion body myositis. Muscle & Nerve. 40: 19-31. PMID 19533646 DOI: 10.1002/Mus.21386  0.92
2009 Young JE, Garden GA, Martinez RA, Tanaka F, Sandoval CM, Smith AC, Sopher BL, Lin A, Fischbeck KH, Ellerby LM, Morrison RS, Taylor JP, La Spada AR. Polyglutamine-expanded androgen receptor truncation fragments activate a Bax-dependent apoptotic cascade mediated by DP5/Hrk. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 1987-97. PMID 19228953 DOI: 10.1523/Jneurosci.4072-08.2009  0.92
2009 Salomons FA, Menéndez-Benito V, Böttcher C, McCray BA, Taylor JP, Dantuma NP. Selective accumulation of aggregation-prone proteasome substrates in response to proteotoxic stress. Molecular and Cellular Biology. 29: 1774-85. PMID 19158272 DOI: 10.1128/Mcb.01485-08  0.92
2008 Nedelsky NB, Todd PK, Taylor JP. Autophagy and the ubiquitin-proteasome system: collaborators in neuroprotection. Biochimica Et Biophysica Acta. 1782: 691-9. PMID 18930136 DOI: 10.1016/J.Bbadis.2008.10.002  0.92
2008 McCray BA, Taylor JP. The role of autophagy in age-related neurodegeneration. Neuro-Signals. 16: 75-84. PMID 18097162 DOI: 10.1159/000109761  0.92
2007 Pandey UB, Batlevi Y, Baehrecke EH, Taylor JP. HDAC6 at the intersection of autophagy, the ubiquitin-proteasome system and neurodegeneration. Autophagy. 3: 643-5. PMID 17912024 DOI: 10.4161/Auto.5050  0.68
2007 Pandey UB, Nie Z, Batlevi Y, McCray BA, Ritson GP, Nedelsky NB, Schwartz SL, DiProspero NA, Knight MA, Schuldiner O, Padmanabhan R, Hild M, Berry DL, Garza D, Hubbert CC, ... ... Taylor JP, et al. HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. Nature. 447: 859-63. PMID 17568747 DOI: 10.1038/Nature05853  0.92
2007 Di Prospero NA, Sumner CJ, Penzak SR, Ravina B, Fischbeck KH, Taylor JP. Safety, tolerability, and pharmacokinetics of high-dose idebenone in patients with Friedreich ataxia. Archives of Neurology. 64: 803-8. PMID 17562928 DOI: 10.1001/Archneur.64.6.803  0.92
2007 Neumann M, Mackenzie IR, Cairns NJ, Boyer PJ, Markesbery WR, Smith CD, Taylor JP, Kretzschmar HA, Kimonis VE, Forman MS. TDP-43 in the ubiquitin pathology of frontotemporal dementia with VCP gene mutations. Journal of Neuropathology and Experimental Neurology. 66: 152-7. PMID 17279000 DOI: 10.1096/Fasebj.21.5.A25  0.92
2004 Zeng XC, Bhasin S, Wu X, Lee JG, Maffi S, Nichols CJ, Lee KJ, Taylor JP, Greene LE, Eisenberg E. Hsp70 dynamics in vivo: effect of heat shock and protein aggregation. Journal of Cell Science. 117: 4991-5000. PMID 15367583 DOI: 10.1242/Jcs.01373  0.92
2004 Piccioni F, Roman BR, Fischbeck KH, Taylor JP. A screen for drugs that protect against the cytotoxicity of polyglutamine-expanded androgen receptor. Human Molecular Genetics. 13: 437-46. PMID 14709594 DOI: 10.1093/Hmg/Ddh045  0.92
2003 Sumner CJ, Huynh TN, Markowitz JA, Perhac JS, Hill B, Coovert DD, Schussler K, Chen X, Jarecki J, Burghes AH, Taylor JP, Fischbeck KH. Valproic acid increases SMN levels in spinal muscular atrophy patient cells. Annals of Neurology. 54: 647-54. PMID 14595654 DOI: 10.1002/Ana.10743  0.92
2003 Taylor JP, Taye AA, Campbell C, Kazemi-Esfarjani P, Fischbeck KH, Min KT. Aberrant histone acetylation, altered transcription, and retinal degeneration in a Drosophila model of polyglutamine disease are rescued by CREB-binding protein. Genes & Development. 17: 1463-8. PMID 12815067 DOI: 10.1101/Gad.1087503  0.92
2003 La Spada AR, Taylor JP. Polyglutamines placed into context. Neuron. 38: 681-4. PMID 12797953 DOI: 10.1016/S0896-6273(03)00328-3  0.92
2003 Taylor JP, Tanaka F, Robitschek J, Sandoval CM, Taye A, Markovic-Plese S, Fischbeck KH. Aggresomes protect cells by enhancing the degradation of toxic polyglutamine-containing protein. Human Molecular Genetics. 12: 749-57. PMID 12651870 DOI: 10.1093/Hmg/Ddg074  0.92
2002 Taylor JP, Fischbeck KH. Altered acetylation in polyglutamine disease: an opportunity for therapeutic intervention? Trends in Molecular Medicine. 8: 195-7. PMID 12067622 DOI: 10.1016/S1471-4914(02)02332-8  0.92
2002 Taylor JP, Hardy J, Fischbeck KH. Toxic proteins in neurodegenerative disease. Science (New York, N.Y.). 296: 1991-5. PMID 12065827 DOI: 10.1126/Science.1067122  0.92
2002 Caplen NJ, Taylor JP, Statham VS, Tanaka F, Fire A, Morgan RA. Rescue of polyglutamine-mediated cytotoxicity by double-stranded RNA-mediated RNA interference. Human Molecular Genetics. 11: 175-84. PMID 11809726 DOI: 10.1093/Hmg/11.2.175  0.92
2000 McCampbell A, Taylor JP, Taye AA, Robitschek J, Li M, Walcott J, Merry D, Chai Y, Paulson H, Sobue G, Fischbeck KH. CREB-binding protein sequestration by expanded polyglutamine. Human Molecular Genetics. 9: 2197-202. PMID 10958659 DOI: 10.1093/Hmg/9.14.2197  0.92
1994 Taylor JP, Khalili K. Activation of HIV-1 transcription by Tat in cells derived from the CNS: evidence for the participation of NF-kappa B--a review. Advances in Neuroimmunology. 4: 291-303. PMID 7874398 DOI: 10.1016/S0960-5428(06)80270-6  0.92
1993 Taylor JP, Kundu M, Khalili K. TAR-independent activation of HIV-1 requires the activation domain but not the RNA-binding domain of Tat. Virology. 195: 780-5. PMID 8337844 DOI: 10.1006/viro.1993.1430  0.92
1992 Taylor JP, Cupp C, Diaz A, Chowdhury M, Khalili K, Jimenez SA, Amini S. Activation of expression of genes coding for extracellular matrix proteins in Tat-producing glioblastoma cells. Proceedings of the National Academy of Sciences of the United States of America. 89: 9617-21. PMID 1409674 DOI: 10.1073/Pnas.89.20.9617  0.92
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